Conan K Wang

ResearcherID ORCID

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 39

Top Topics

Breast Cancer Cells

Tyrosine Kinase

Top Venues

Nature chemistry

Journal of medicinal chemistry

ACS chemical biology

Science immunology

This page only lists publications with an associated author ORCID identifier.

Publications

Fabian B H Rehm, Tristan J Tyler, Yan Zhou, Yen-Hua Huang, Conan K Wang, Nicole Lawrence, David J Craik, Thomas Durek
Repurposing a plant peptide cyclase for targeted lysine acylation. Nature chemistry (2024)
Zhihao Jiang, Yen-Hua Huang, Quentin Kaas, David J Craik, Conan K Wang
Structure and Activity of Reconstructed Pseudo-Ancestral Cyclotides. ChemMedChem (2024)
Fabian B H Rehm, Tristan J Tyler, Yan Zhou, Yen-Hua Huang, Conan K Wang, Nicole Lawrence, David J Craik, Thomas Durek
Repurposing a plant peptide cyclase for targeted lysine acylation. Nature chemistry (2024)
Fabian B H Rehm, Tristan J Tyler, Yan Zhou, Yen-Hua Huang, Conan K Wang, Nicole Lawrence, David J Craik, Thomas Durek
Repurposing a plant peptide cyclase for targeted lysine acylation. Nature chemistry (2024)
Fabian B H Rehm, Tristan J Tyler, Yan Zhou, Yen-Hua Huang, Conan K Wang, Nicole Lawrence, David J Craik, Thomas Durek
Author Correction: Repurposing a plant peptide cyclase for targeted lysine acylation. Nature chemistry (2024)
Fabian B H Rehm, Tristan J Tyler, Yan Zhou, Yen-Hua Huang, Conan K Wang, Nicole Lawrence, David J Craik, Thomas Durek
Author Correction: Repurposing a plant peptide cyclase for targeted lysine acylation. Nature chemistry (2024)
Grégoire Jean-Baptiste Philippe, Yen-Hua Huang, Anna Mittermeier, Christopher J Brown, Quentin Kaas, Siti Radhiah Ramlan, Conan K Wang, David Lane, Alexander Loewer, Sónia Troeira Henriques, David J Craik
Delivery to, and Reactivation of, the p53 Pathway in Cancer Cells Using a Grafted Cyclotide Conjugated with a Cell-Penetrating Peptide. Journal of medicinal chemistry (2024)
Grégoire Jean-Baptiste Philippe, Yen-Hua Huang, Anna Mittermeier, Christopher J Brown, Quentin Kaas, Siti Radhiah Ramlan, Conan K Wang, David Lane, Alexander Loewer, Sónia Troeira Henriques, David J Craik
Delivery to, and Reactivation of, the p53 Pathway in Cancer Cells Using a Grafted Cyclotide Conjugated with a Cell-Penetrating Peptide. Journal of medicinal chemistry 67 (2) (2024)
Fabian B H Rehm, Tristan J Tyler, Yan Zhou, Yen-Hua Huang, Conan K Wang, Nicole Lawrence, David J Craik, Thomas Durek
Repurposing a plant peptide cyclase for targeted lysine acylation. Nature chemistry (2024)
Biswajit Biswas, Yen-Hua Huang, David J Craik, Conan K Wang
The prospect of substrate-based kinase inhibitors to improve target selectivity and overcome drug resistance. Chemical science 15 (33) (2024)
Fabian B H Rehm, Tristan J Tyler, Yan Zhou, Yen-Hua Huang, Conan K Wang, Nicole Lawrence, David J Craik, Thomas Durek
Author Correction: Repurposing a plant peptide cyclase for targeted lysine acylation. Nature chemistry (2024)
Negin Khatibi, Yen-Hua Huang, Conan K Wang, Thomas Durek, Edward K Gilding, David J Craik
Isolation and Characterization of Insecticidal Cyclotides from Viola communis . Journal of natural products (2024)
Grégoire Jean-Baptiste Philippe, Yen-Hua Huang, Anna Mittermeier, Christopher J Brown, Quentin Kaas, Siti Radhiah Ramlan, Conan K Wang, David Lane, Alexander Loewer, Sónia Troeira Henriques, David J Craik
Delivery to, and Reactivation of, the p53 Pathway in Cancer Cells Using a Grafted Cyclotide Conjugated with a Cell-Penetrating Peptide. Journal of medicinal chemistry 67 (2) (2024)
Zhihao Jiang, Yen-Hua Huang, Quentin Kaas, David J Craik, Conan K Wang
Structure and Activity of Reconstructed Pseudo-Ancestral Cyclotides. ChemMedChem 19 (14) (2024)
Biswajit Biswas, Yen-Hua Huang, David J Craik, Conan K Wang
The prospect of substrate-based kinase inhibitors to improve target selectivity and overcome drug resistance. Chemical science 15 (33) (2024)
Zhian Chen, Yanfang Cui, Yin Yao, Bo Liu, Joseph Yunis, Xin Gao, Naiqi Wang, Pablo F Cañete, Zewen Kelvin Tuong, Hongjian Sun, Hao Wang, Si-Ling Yang, Runli Wang, Yew Ann Leong, David Simon Davis, Jiahuan Qin, Kaili Liang, Jun Deng, Conan K Wang, Yen-Hua Huang, Jonathan A Roco, Sam Nettelfield, Huaming Zhu, Huajun Xu, Zhijia Yu, David J Craik, Zheng Liu, Hai Qi, Christopher R Parish, Di Yu
Heparan sulfate regulates IL-21 bioavailability and signal strength that control germinal center B cell selection and differentiation. Science immunology 8 (80) (2023)
Zhian Chen, Yanfang Cui, Yin Yao, Bo Liu, Joseph Yunis, Xin Gao, Naiqi Wang, Pablo F Cañete, Zewen Kelvin Tuong, Hongjian Sun, Hao Wang, Si-Ling Yang, Runli Wang, Yew Ann Leong, David Simon Davis, Jiahuan Qin, Kaili Liang, Jun Deng, Conan K Wang, Yen-Hua Huang, Jonathan A Roco, Sam Nettelfield, Huaming Zhu, Huajun Xu, Zhijia Yu, David J Craik, Zheng Liu, Hai Qi, Christopher R Parish, Di Yu
Heparan sulfate regulates IL-21 bioavailability and signal strength that control germinal center B cell selection and differentiation. Science immunology 8 (80) (2023)
Zhian Chen, Yanfang Cui, Yin Yao, Bo Liu, Joseph Yunis, Xin Gao, Naiqi Wang, Pablo F Cañete, Zewen Kelvin Tuong, Hongjian Sun, Hao Wang, Si-Ling Yang, Runli Wang, Yew Ann Leong, David Simon Davis, Jiahuan Qin, Kaili Liang, Jun Deng, Conan K Wang, Yen-Hua Huang, Jonathan A Roco, Sam Nettelfield, Huaming Zhu, Huajun Xu, Zhijia Yu, David J Craik, Zheng Liu, Hai Qi, Christopher R Parish, Di Yu
Heparan sulfate regulates IL-21 bioavailability and signal strength that control germinal center B cell selection and differentiation. Science immunology 8 (80) (2023)
Zhian Chen, Yanfang Cui, Yin Yao, Bo Liu, Joseph Yunis, Xin Gao, Naiqi Wang, Pablo F Cañete, Zewen Kelvin Tuong, Hongjian Sun, Hao Wang, Si-Ling Yang, Runli Wang, Yew Ann Leong, David Simon Davis, Jiahuan Qin, Kaili Liang, Jun Deng, Conan K Wang, Yen-Hua Huang, Jonathan A Roco, Sam Nettelfield, Huaming Zhu, Huajun Xu, Zhijia Yu, David J Craik, Zheng Liu, Hai Qi, Christopher R Parish, Di Yu
Heparan sulfate regulates IL-21 bioavailability and signal strength that control germinal center B cell selection and differentiation. Science immunology 8 (80) (2023)
Yuhui Zhang, Li Wang, Benjamin J Tombling, Carmen Lammi, Yen-Hua Huang, Yue Li, Martina Bartolomei, Bin Hong, David J Craik, Conan K Wang
Improving Stability Enhances In Vivo Efficacy of a PCSK9 Inhibitory Peptide. Journal of the American Chemical Society 144 (42) (2022)
Sixin Tian, Thomas Durek, Conan K Wang, Christina N Zdenek, Bryan G Fry, David J Craik, Simon J de Veer
Engineering the Cyclization Loop of MCoTI-II Generates Targeted Cyclotides that Potently Inhibit Factor XIIa. Journal of medicinal chemistry 65 (23) (2022)
Benjamin J Tombling, Carmen Lammi, Carlotta Bollati, Anna Anoldi, David J Craik, Conan K Wang
Increased Valency Improves Inhibitory Activity of Peptides Targeting Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9). Chembiochem : a European journal of chemical biology 22 (12) (2021)
Huawu Yin, Yen-Hua Huang, Sarah A Best, Kate D Sutherland, David J Craik, Conan K Wang
An Integrated Molecular Grafting Approach for the Design of Keap1-Targeted Peptide Inhibitors. ACS chemical biology 16 (7) (2021)
Yen-Hua Huang, Qingdan Du, Zhihao Jiang, Gordon J King, Brett M Collins, Conan K Wang, David J Craik
Enabling Efficient Folding and High-Resolution Crystallographic Analysis of Bracelet Cyclotides. Molecules (Basel, Switzerland) 26 (18) (2021)
Huawu Yin, Xiuman Zhou, Yen-Hua Huang, Gordon J King, Brett M Collins, Yanfeng Gao, David J Craik, Conan K Wang
Rational Design of Potent Peptide Inhibitors of the PD-1:PD-L1 Interaction for Cancer Immunotherapy. Journal of the American Chemical Society 143 (44) (2021)
Benjamin J Tombling, Carmen Lammi, Nicole Lawrence, Jianqiang Li, Anna Arnoldi, David J Craik, Conan K Wang
Engineered EGF-A Peptides with Improved Affinity for Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9). ACS chemical biology 16 (2) (2021)
Kuok Yap, Junqiao Du, Fabian B H Rehm, Shyn Ric Tang, Yan Zhou, Jing Xie, Conan K Wang, Simon J de Veer, Linda H L Lua, Thomas Durek, David J Craik
Yeast-based bioproduction of disulfide-rich peptides and their cyclization via asparaginyl endopeptidases. Nature protocols 16 (3) (2021)
Andrew M White, Simon J de Veer, Guojie Wu, Peta J Harvey, Kuok Yap, Gordon J King, Joakim E Swedberg, Conan K Wang, Ruby H P Law, Thomas Durek, David J Craik
Application and Structural Analysis of Triazole-Bridged Disulfide Mimetics in Cyclic Peptides. Angewandte Chemie (International ed. in English) 59 (28) (2020)
Benjamin J Tombling, Carmen Lammi, Nicole Lawrence, Edward K Gilding, Giovanni Grazioso, David J Craik, Conan K Wang
Bioactive Cyclization Optimizes the Affinity of a Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Peptide Inhibitor. Journal of medicinal chemistry 64 (5) (2020)
Benjamin J Tombling, Conan K Wang, David J Craik
EGF-like and Other Disulfide-rich Microdomains as Therapeutic Scaffolds. Angewandte Chemie (International ed. in English) 59 (28) (2020)
Huawu Yin, Yen-Hua Huang, Kirsten Deprey, Nicholas D Condon, Joshua A Kritzer, David J Craik, Conan K Wang
Cellular Uptake and Cytosolic Delivery of a Cyclic Cystine Knot Scaffold. ACS chemical biology 15 (6) (2020)
Huawu Yin, David J Craik, Conan K Wang
Anchor Residues Guide Form and Function in Grafted Peptides. Angewandte Chemie (International ed. in English) 58 (23) (2019)
Sónia Troeira Henriques, Hayden Peacock, Aurélie H Benfield, Conan K Wang, David J Craik
Is the Mirror Image a True Reflection? Intrinsic Membrane Chirality Modulates Peptide Binding. Journal of the American Chemical Society 141 (51) (2019)
Conan K Wang, David J Craik
Toward Structure Determination of Disulfide-Rich Peptides Using Chemical Shift-Based Methods. The journal of physical chemistry. B 123 (9) (2019)
Conan K Wang, Joakim E Swedberg, Peta J Harvey, Quentin Kaas, David J Craik
Conformational Flexibility Is a Determinant of Permeability for Cyclosporin. The journal of physical chemistry. B 122 (8) (2018)
Conan K Wang, Hafiza Abdul Ghani, Anna Bundock, Joachim Weidmann, Peta J Harvey, Ingrid A Edwards, Christina I Schroeder, Joakim E Swedberg, David J Craik
Calcium-Mediated Allostery of the EGF Fold. ACS chemical biology 13 (6) (2018)
Suelem D Ramalho, Conan K Wang, Gordon J King, Karl A Byriel, Yen-Hua Huang, Vanderlan da Silva Bolzani, David J Craik
Synthesis, Racemic X-ray Crystallographic, and Permeability Studies of Bioactive Orbitides from Jatropha Species. Journal of natural products 81 (11) (2018)
Paola G Ojeda, Sónia Troeira Henriques, Yijun Pan, Joseph A Nicolazzo, David J Craik, Conan K Wang
Lysine to arginine mutagenesis of chlorotoxin enhances its cellular uptake. Biopolymers 108 (5) (2018)
Xiaosa Wu, Yen-Hua Huang, Quentin Kaas, Peta J Harvey, Conan K Wang, Han-Shen Tae, David J Adams, David J Craik
Backbone cyclization of analgesic conotoxin GeXIVA facilitates direct folding of the ribbon isomer. The Journal of biological chemistry 292 (41) (2017)