David J Adams (D J Adams)

ResearcherID ResearcherID Loop profile UOW Scholars ORCID

Publication Activity (10 Years)

Years Active: 2014-2024
Publications (10 Years): 53

Top Venues

Marine drugs

Journal of medicinal chemistry

British journal of pharmacology

ACS chemical neuroscience

University of Wollongong

University of New South Wales (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

University of Wollongong Jan 01 2019

Australia

Distinguished Professor :: Illawarra Health & Medical Research Institute (IHMRI)

RMIT University

Australia

Honorary Professor :: School of Medical Sciences

University of Wollongong Illawarra Health and Medical Research Institute Dec 12 2015

Australia

CEO and Executive Director :: Illawarra Health and Medical Research Institute (IHMRI)

University of Queensland

Australia

Honorary Professor :: School of Biomedical Sciences

RMIT University

Australia

Director :: Health Innovations Research Institute

RMIT University

Australia

Acting Deputy Vice-Chancellor Research & Innovation

University of Queensland Jan 01 2008 - Jul 01 2009

Australia

Director Neuroscience Program :: Queensland Brain Institute

University of Queensland Jan 01 1995 - Jul 01 2009

Australia

Professor and Chair of Physiology :: Physiology and Pharmacology

University of Queensland Jul 01 2000 - Dec 31 2007

Australia

Head of School :: Biomedical Sciences

University of Queensland Jan 01 1998 - Jul 01 2000

Australia

Head of Department :: Physiology and Pharmacology

University of Miami School of Medicine Jan 01 1993 - Jul 01 1995

United States

Professor :: Molecular & Cellular Pharmacology

University of Miami School of Medicine

United States

Associate Professor :: Molecular & Cellular Pharmacology

University of Miami School of Medicine

United States

Assistant Professor :: Pharmacology

University College London

United Kingdom

Beit Memorial Medical Research Fellow :: Pharmacology

Marine Biological Laboratory

United States

Grass Fellowship in Neurophysiology

University of Washington

United States

MDA Postdoctoral Research Fellow :: Physiology and Biophysics

Education History

University of New South Wales

Australia

PHD :: Physiology and Pharmacology

University of New South Wales

Australia

BSC :: Physiology

Publications

Xiao Li, Han-Shen Tae, Shen Chen, Arsalan Yousuf, Linhong Huang, Jinghui Zhang, Tao Jiang, David J Adams, Ri-Lei Yu
Dual Antagonism of α9α10 nAChR and GABA B Receptor-Coupled Ca V 2.2 Channels by an Analgesic αO-Conotoxin Analogue. Journal of medicinal chemistry 67 (2) (2024)
Tianmiao Li, Han-Shen Tae, Jiazhen Liang, Zixuan Zhang, Xiao Li, Tao Jiang, David J Adams, Ri-Lei Yu
Rational Design of Potent α-Conotoxin PeIA Analogues with Non-Natural Amino Acids for the Inhibition of Human α9α10 Nicotinic Acetylcholine Receptors. Marine drugs 22 (3) (2024)
Tianmiao Li, Han-Shen Tae, Jiazhen Liang, Zixuan Zhang, Xiao Li, Tao Jiang, David J Adams, Ri-Lei Yu
Rational Design of Potent α-Conotoxin PeIA Analogues with Non-Natural Amino Acids for the Inhibition of Human α9α10 Nicotinic Acetylcholine Receptors. Marine drugs 22 (3) (2024)
Xiao Li, Han-Shen Tae, Shen Chen, Arsalan Yousuf, Linhong Huang, Jinghui Zhang, Tao Jiang, David J Adams, Ri-Lei Yu
Dual Antagonism of α9α10 nAChR and GABA B Receptor-Coupled Ca V 2.2 Channels by an Analgesic αO-Conotoxin Analogue. Journal of medicinal chemistry (2024)
Xiao Li, Han-Shen Tae, Shen Chen, Arsalan Yousuf, Linhong Huang, Jinghui Zhang, Tao Jiang, David J Adams, Ri-Lei Yu
Dual Antagonism of α9α10 nAChR and GABA B Receptor-Coupled Ca V 2.2 Channels by an Analgesic αO-Conotoxin Analogue. Journal of medicinal chemistry 67 (2) (2024)
Tianmiao Li, Han-Shen Tae, Jiazhen Liang, Zixuan Zhang, Xiao Li, Tao Jiang, David J Adams, Ri-Lei Yu
Rational Design of Potent α-Conotoxin PeIA Analogues with Non-Natural Amino Acids for the Inhibition of Human α9α10 Nicotinic Acetylcholine Receptors. Marine drugs 22 (3) (2024)
Xiao Li, Han-Shen Tae, Shen Chen, Arsalan Yousuf, Linhong Huang, Jinghui Zhang, Tao Jiang, David J Adams, Ri-Lei Yu
Dual Antagonism of α9α10 nAChR and GABA B Receptor-Coupled Ca V 2.2 Channels by an Analgesic αO-Conotoxin Analogue. Journal of medicinal chemistry (2024)
Bankala Krishnarjuna, Punnepalli Sunanda, Jeffrey Seow, Han-Shen Tae, Samuel D Robinson, Alessia Belgi, Andrea J Robinson, Helena Safavi-Hemami, David J Adams, Raymond S Norton
Characterisation of Elevenin-Vc1 from the Venom of Conus victoriae : A Structural Analogue of α-Conotoxins. Marine drugs 21 (2) (2023)
Bankala Krishnarjuna, Punnepalli Sunanda, Jeffrey Seow, Han-Shen Tae, Samuel D Robinson, Alessia Belgi, Andrea J Robinson, Helena Safavi-Hemami, David J Adams, Raymond S Norton
Characterisation of Elevenin-Vc1 from the Venom of Conus victoriae : A Structural Analogue of α-Conotoxins. Marine drugs 21 (2) (2023)
Mahima Jadav, Deep Pooja, David J Adams, Hitesh Kulhari
Advances in Xanthan Gum-Based Systems for the Delivery of Therapeutic Agents. Pharmaceutics 15 (2) (2023)
Han-Shen Tae, Marcelo O Ortells, Bassel J Tekarli, Dina Manetti, Maria Novella Romanelli, J Michael McIntosh, David J Adams, Hugo R Arias
DM506 (3-Methyl-1,2,3,4,5,6-hexahydroazepino[4,5- b ]indole fumarate), a Novel Derivative of Ibogamine, Inhibits α7 and α9α10 Nicotinic Acetylcholine Receptors by Different Allosteric Mechanisms. ACS chemical neuroscience (2023)
Bankala Krishnarjuna, Punnepalli Sunanda, Jeffrey Seow, Han-Shen Tae, Samuel D Robinson, Alessia Belgi, Andrea J Robinson, Helena Safavi-Hemami, David J Adams, Raymond S Norton
Characterisation of Elevenin-Vc1 from the Venom of Conus victoriae : A Structural Analogue of α-Conotoxins. Marine drugs 21 (2) (2023)
Bankala Krishnarjuna, Punnepalli Sunanda, Jeffrey Seow, Han-Shen Tae, Samuel D Robinson, Alessia Belgi, Andrea J Robinson, Helena Safavi-Hemami, David J Adams, Raymond S Norton
Characterisation of Elevenin-Vc1 from the Venom of Conus victoriae : A Structural Analogue of α-Conotoxins. Marine drugs 21 (2) (2023)
Mahima Jadav, Deep Pooja, David J Adams, Hitesh Kulhari
Advances in Xanthan Gum-Based Systems for the Delivery of Therapeutic Agents. Pharmaceutics 15 (2) (2023)
Rocio K Finol-Urdaneta, Boris S Zhorov, Daniel G Baden, David J Adams
Brevetoxin versus Brevenal Modulation of Human Nav1 Channels. Marine drugs 21 (7) (2023)
Mahima Jadav, Deep Pooja, David J Adams, Hitesh Kulhari
Advances in Xanthan Gum-Based Systems for the Delivery of Therapeutic Agents. Pharmaceutics 15 (2) (2023)
Bankala Krishnarjuna, Punnepalli Sunanda, Jeffrey Seow, Han-Shen Tae, Samuel D Robinson, Alessia Belgi, Andrea J Robinson, Helena Safavi-Hemami, David J Adams, Raymond S Norton
Characterisation of Elevenin-Vc1 from the Venom of Conus victoriae : A Structural Analogue of α-Conotoxins. Marine drugs 21 (2) (2023)
Mahima Jadav, Deep Pooja, David J Adams, Hitesh Kulhari
Advances in Xanthan Gum-Based Systems for the Delivery of Therapeutic Agents. Pharmaceutics 15 (2) (2023)
Rocio K Finol-Urdaneta, Jeffrey R McArthur, Ashraf Aboelela, Richard S Bujaroski, Hiwa Majed, Alejandra Rangel, David J Adams, Marie Ranson, Michael J Kelso, Benjamin J Buckley
Automated Patch Clamp Screening of Amiloride and 5- N , N -Hexamethyleneamiloride Analogs Identifies 6-Iodoamiloride as a Potent Acid-Sensing Ion Channel Inhibitor. Molecular pharmaceutics (2023)
Patrick Wilhelm, Karen Luna-Ramirez, Yanni K-Y Chin, Zoltan Dekan, Nikita Abraham, Han-Shen Tae, Chun Yuen Chow, David A Eagles, Glenn F King, Richard J Lewis, David J Adams, Paul F Alewood
Cysteine-Rich α-Conotoxin SII Displays Novel Interactions at the Muscle Nicotinic Acetylcholine Receptor. ACS chemical neuroscience 13 (8) (2022)
Jiazhen Liang, Han-Shen Tae, Zitong Zhao, Xiao Li, Jinghui Zhang, Shen Chen, Tao Jiang, David J Adams, Ri-Lei Yu
Mechanism of Action and Structure-Activity Relationship of α-Conotoxin Mr1.1 at the Human α9α10 Nicotinic Acetylcholine Receptor. Journal of medicinal chemistry (2022)
Yuan Ma, Qiushi Cao, Mengke Yang, Yue Gao, Shuiping Fu, Wenhao Du, David J Adams, Tao Jiang, Han-Shen Tae, Ri-Lei Yu
Single-Disulfide Conopeptide Czon1107, an Allosteric Antagonist of the Human α3β4 Nicotinic Acetylcholine Receptor. Marine drugs 20 (8) (2022)
Alexander A Harper, David J Adams
Electrical properties and synaptic transmission in mouse intracardiac ganglion neurons in situ. Physiological reports 9 (18) (2022)
Jeffrey R McArthur, Jierong Wen, Andrew Hung, Rocio K Finol-Urdaneta, David J Adams
µ-Theraphotoxin Pn3a inhibition of Ca V 3.3 channels reveals a novel isoform-selective drug binding site. eLife 11 (2022)
Anuja R Bony, Jeffrey R McArthur, Akari Komori, Ann R Wong, Andrew Hung, David J Adams
Analgesic α-Conotoxin Binding Site on the Human GABA B Receptor. Molecular pharmacology 102 (4) (2022)
Rocio K Finol-Urdaneta, Rebekah Ziegman, Zoltan Dekan, Jeffrey R McArthur, Stewart Heitmann, Karen Luna-Ramirez, Han-Shen Tae, Alexander Mueller, Hana Starobova, Yanni K-Y Chin, Joshua S Wingerd, Eivind A B Undheim, Ben Cristofori-Armstrong, Adam P Hill, Volker Herzig, Glenn F King, Irina Vetter, Lachlan D Rash, David J Adams, Paul F Alewood
Multitarget nociceptor sensitization by a promiscuous peptide from the venom of the King Baboon spider. Proceedings of the National Academy of Sciences of the United States of America 119 (5) (2022)
Arsalan Yousuf, Xiaosa Wu, Anuja R Bony, Mahsa Sadeghi, Yen-Hua Huang, David J Craik, David J Adams
ɑO-Conotoxin GeXIVA isomers modulate N-type calcium (CaV 2.2) channels and inwardly-rectifying potassium (GIRK) channels via GABAB receptor activation. Journal of neurochemistry (2021)
Alessia Belgi, James V Burnley, Christopher A MacRaild, Sandeep Chhabra, Khaled A Elnahriry, Samuel D Robinson, Simon G Gooding, Han-Shen Tae, Peter Bartels, Mahsa Sadeghi, Fei-Yue Zhao, Haifeng Wei, David Spanswick, David J Adams, Raymond S Norton, Andrea J Robinson
Alkyne-Bridged α-Conotoxin Vc1.1 Potently Reverses Mechanical Allodynia in Neuropathic Pain Models. Journal of medicinal chemistry 64 (6) (2021)
Anuja R Bony, Jeffrey R McArthur, Rocio K Finol-Urdaneta, David J Adams
Analgesic α-conotoxins modulate native and recombinant GIRK1/2 channels via activation of GABAB receptors and reduce neuroexcitability. British journal of pharmacology (2021)
S T Nevin, Nicole Lawrence, Annette Nicke, Richard James Lewis, David J Adams
Functional modulation of the human voltage-gated sodium channel NaV1.8 by auxiliary β subunits. Channels (Austin, Tex.) 15 (1) (2021)
Huying Ning, Biling Huang, Han-Shen Tae, Zhuguo Liu, Shuo Yu, Liang Li, Longxiao Zhang, David J Adams, Chenyun Guo, Qiuyun Dai
α-Conotoxin Bt1.8 from Conus betulinus selectively inhibits α6/α3β2β3 and α3β2 nicotinic acetylcholine receptor subtypes. Journal of neurochemistry 159 (1) (2021)
Markus Muttenthaler, Glenn F King, David J Adams, Paul F Alewood
Trends in peptide drug discovery. Nature reviews. Drug discovery 20 (4) (2021)
Chun Shin Foo, Chacko Jobichen, Varuna Hassan-Puttaswamy, Zoltan Dekan, Han-Shen Tae, Daniel Bertrand, David J Adams, Paul F Alewood, J Sivaraman, Selvanayagam Nirthanan, R Manjunatha Kini
Fulditoxin, representing a new class of dimeric snake toxins, defines novel pharmacology at nicotinic ACh receptors. British journal of pharmacology 177 (8) (2020)
Qingliang Xu, Han-Shen Tae, Zihao Wang, Tao Jiang, David J Adams, Ri-Lei Yu
Rational Design of α-Conotoxin RegIIA Analogues Selectively Inhibiting the Human α3β2 Nicotinic Acetylcholine Receptor through Computational Scanning. ACS chemical neuroscience 11 (18) (2020)
Jiazhen Liang, Han-Shen Tae, Xiaoxiao Xu, Tao Jiang, David J Adams, Ri-Lei Yu
Dimerization of α-Conotoxins as a Strategy to Enhance the Inhibition of the Human α7 and α9α10 Nicotinic Acetylcholine Receptors. Journal of medicinal chemistry 63 (6) (2020)
Jierong Wen, David J Adams, Andrew Hung
Interactions of the α3β2 Nicotinic Acetylcholine Receptor Interfaces with α-Conotoxin LsIA and its Carboxylated C-terminus Analogue: Molecular Dynamics Simulations. Marine drugs 18 (7) (2020)
Hugo R Arias, Carla Ghelardini, Elena Lucarini, Han-Shen Tae, Arsalan Yousuf, Irina Marcovich, Dina Manetti, Maria Novella Romanelli, Ana Belén Elgoyhen, David J Adams, Lorenzo Di Cesare Mannelli
(E)-3-Furan-2-yl-N-p-tolyl-acrylamide and its Derivative DM489 Decrease Neuropathic Pain in Mice Predominantly by α7 Nicotinic Acetylcholine Receptor Potentiation. ACS chemical neuroscience 11 (21) (2020)
Jeffrey R McArthur, Rocio K Finol-Urdaneta, David J Adams
Analgesic transient receptor potential vanilloid-1-active compounds inhibit native and recombinant T-type calcium channels. British journal of pharmacology 176 (13) (2019)
Xin Chu, Han-Shen Tae, Qingliang Xu, Tao Jiang, David J Adams, Ri-Lei Yu
α-Conotoxin Vc1.1 Structure-Activity Relationship at the Human α9α10 Nicotinic Acetylcholine Receptor Investigated by Minimal Side Chain Replacement. ACS chemical neuroscience 10 (10) (2019)
Ri-Lei Yu, Han-Shen Tae, Qingliang Xu, David J Craik, David J Adams, Tao Jiang, Quentin Kaas
Molecular dynamics simulations of dihydro-β-erythroidine bound to the human α4β2 nicotinic acetylcholine receptor. British journal of pharmacology 176 (15) (2019)
Joel Castro, Luke Grundy, Annemie Deiteren, Andrea M Harrington, Tracey O'Donnell, Jessica Maddern, Jessi Moore, Sonia Garcia-Caraballo, Grigori Y Rychkov, Rilei Yu, Quentin Kaas, David J Craik, David J Adams, Stuart M Brierley
Cyclic analogues of α-conotoxin Vc1.1 inhibit colonic nociceptors and provide analgesia in a mouse model of chronic abdominal pain. British journal of pharmacology 175 (12) (2018)
Zhuguo Liu, Peter Bartels, Mahsa Sadeghi, Tianpeng Du, Qing Dai, Cui Zhu, Shuo Yu, Shuo Wang, Mingxin Dong, Ting Sun, Jiabin Guo, Shuangqing Peng, Ling Jiang, David J Adams, Qiuyun Dai
A novel α-conopeptide Eu1.6 inhibits N-type (CaV2.2) calcium channels and exhibits potent analgesic activity. Scientific reports 8 (1) (2018)
Fengtao Cai, Ning Xu, Zhuguo Liu, Rong Ding, Shuo Yu, Mingxin Dong, Shuo Wang, Jintao Shen, Han-Shen Tae, David J Adams, Xuerong Zhang, Qiuyun Dai
Targeting of N-Type Calcium Channels via GABAB-Receptor Activation by α-Conotoxin Vc1.1 Variants Displaying Improved Analgesic Activity. Journal of medicinal chemistry 61 (22) (2018)
Silmara R Sousa, Jeffrey R McArthur, Andreas Brust, Rebecca F Bhola, K Johan Rosengren, Lotten Ragnarsson, Sebastien Dutertre, Paul F Alewood, Macdonald J Christie, David J Adams, Irina Vetter, Richard J Lewis
Novel analgesic ω-conotoxins from the vermivorous cone snail Conus moncuri provide new insights into the evolution of conopeptides. Scientific reports 8 (1) (2018)
Mahsa Sadeghi, Bodil B Carstens, Brid P Callaghan, James T Daniel, Han-Shen Tae, Tracey O'Donnell, Joel Castro, Stuart M Brierley, David J Adams, David J Craik, Richard J Clark
Structure-Activity Studies Reveal the Molecular Basis for GABAB-Receptor Mediated Inhibition of High Voltage-Activated Calcium Channels by α-Conotoxin Vc1.1. ACS chemical biology 13 (6) (2018)
Ri-Lei Yu, Han-Shen Tae, Nargis Tabassum, Juan Shi, Tao Jiang, David J Adams
Molecular Determinants Conferring the Stoichiometric-Dependent Activity of α-Conotoxins at the Human α9α10 Nicotinic Acetylcholine Receptor Subtype. Journal of medicinal chemistry 61 (10) (2018)
Peta J Harvey, Nyoman D Kurniawan, Rocio K Finol-Urdaneta, Jeffrey R McArthur, Dorien Van Lysebetten, Thomas S Dash, Justine M Hill, David J Adams, Thomas Durek, David J Craik
NMR Structure of μ-Conotoxin GIIIC: Leucine 18 Induces Local Repacking of the N-Terminus Resulting in Reduced NaV Channel Potency. Molecules (Basel, Switzerland) 23 (10) (2018)
Joshua S Wingerd, Christine A Mozar, Christine A Ussing, Swetha S Murali, Yanni K-Y Chin, Ben Cristofori-Armstrong, Thomas Durek, John Gilchrist, Christopher W Vaughan, Frank Bosmans, David J Adams, Richard J Lewis, Paul F Alewood, Mehdi Mobli, Macdonald J Christie, Lachlan D Rash
The tarantula toxin β/δ-TRTX-Pre1a highlights the importance of the S1-S2 voltage-sensor region for sodium channel subtype selectivity. Scientific reports 7 (1) (2017)
Thomas Durek, Irina V Shelukhina, Han-Shen Tae, Panumart Thongyoo, Ekaterina N Spirova, Denis S Kudryavtsev, Igor E Kasheverov, Grazyna Faure, Pierre-Jean Corringer, David J Craik, David J Adams, Victor I Tsetlin
Interaction of Synthetic Human SLURP-1 with the Nicotinic Acetylcholine Receptors. Scientific reports 7 (1) (2017)
Hartmut Cuny, Rilei Yu, Han-Shen Tae, Shiva N Kompella, David J Adams
α-Conotoxins active at α3-containing nicotinic acetylcholine receptors and their molecular determinants for selective inhibition. British journal of pharmacology 175 (11) (2017)
Xiaosa Wu, Yen-Hua Huang, Quentin Kaas, Peta J Harvey, Conan K Wang, Han-Shen Tae, David J Adams, David J Craik
Backbone cyclization of analgesic conotoxin GeXIVA facilitates direct folding of the ribbon isomer. The Journal of biological chemistry 292 (41) (2017)
Jeffrey R McArthur, Leonid Motin, Ellen C Gleeson, Sandro Spiller, Richard James Lewis, Peter J Duggan, Kellie L Tuck, David J Adams
Inhibition of human N- and T-type calcium channels by an ortho-phenoxyanilide derivative, MONIRO-1. British journal of pharmacology 175 (12) (2017)
Hartmut Cuny, Shiva N Kompella, Han-Shen Tae, Rilei Yu, David J Adams
Key Structural Determinants in the Agonist Binding Loops of Human β2 and β4 Nicotinic Acetylcholine Receptor Subunits Contribute to α3β4 Subtype Selectivity of α-Conotoxins. The Journal of biological chemistry 291 (45) (2016)
Thuan G Huynh, Hartmut Cuny, Paul A Slesinger, David J Adams
Novel mechanism of voltage-gated N-type (Cav2.2) calcium channel inhibition revealed through α-conotoxin Vc1.1 activation of the GABA(B) receptor. Molecular pharmacology 87 (2) (2014)

David J Adams.css-eqlu8i{font-size:small;padding-left:4px;} (D J Adams)

Publication Activity (10 Years)

Top Topics

Top Venues

David J Adams (D J Adams)