Yen-Hua Huang

ResearcherID Scopus Author ID ORCID

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 37

Top Topics

Structural Basis

Signaling Pathway

Chronic Myeloid Leukemia

Top Venues

Nature chemistry

ACS chemical biology

Journal of natural products

Journal of medicinal chemistry

This page only lists publications with an associated author ORCID identifier.

Publications

Fabian B H Rehm, Tristan J Tyler, Yan Zhou, Yen-Hua Huang, Conan K Wang, Nicole Lawrence, David J Craik, Thomas Durek
Repurposing a plant peptide cyclase for targeted lysine acylation. Nature chemistry (2024)
Zhihao Jiang, Yen-Hua Huang, Quentin Kaas, David J Craik, Conan K Wang
Structure and Activity of Reconstructed Pseudo-Ancestral Cyclotides. ChemMedChem (2024)
Fabian B H Rehm, Tristan J Tyler, Yan Zhou, Yen-Hua Huang, Conan K Wang, Nicole Lawrence, David J Craik, Thomas Durek
Repurposing a plant peptide cyclase for targeted lysine acylation. Nature chemistry (2024)
Fabian B H Rehm, Tristan J Tyler, Yan Zhou, Yen-Hua Huang, Conan K Wang, Nicole Lawrence, David J Craik, Thomas Durek
Repurposing a plant peptide cyclase for targeted lysine acylation. Nature chemistry (2024)
Fabian B H Rehm, Tristan J Tyler, Yan Zhou, Yen-Hua Huang, Conan K Wang, Nicole Lawrence, David J Craik, Thomas Durek
Author Correction: Repurposing a plant peptide cyclase for targeted lysine acylation. Nature chemistry (2024)
Fabian B H Rehm, Tristan J Tyler, Yan Zhou, Yen-Hua Huang, Conan K Wang, Nicole Lawrence, David J Craik, Thomas Durek
Author Correction: Repurposing a plant peptide cyclase for targeted lysine acylation. Nature chemistry (2024)
Grégoire Jean-Baptiste Philippe, Yen-Hua Huang, Anna Mittermeier, Christopher J Brown, Quentin Kaas, Siti Radhiah Ramlan, Conan K Wang, David Lane, Alexander Loewer, Sónia Troeira Henriques, David J Craik
Delivery to, and Reactivation of, the p53 Pathway in Cancer Cells Using a Grafted Cyclotide Conjugated with a Cell-Penetrating Peptide. Journal of medicinal chemistry (2024)
Grégoire Jean-Baptiste Philippe, Yen-Hua Huang, Anna Mittermeier, Christopher J Brown, Quentin Kaas, Siti Radhiah Ramlan, Conan K Wang, David Lane, Alexander Loewer, Sónia Troeira Henriques, David J Craik
Delivery to, and Reactivation of, the p53 Pathway in Cancer Cells Using a Grafted Cyclotide Conjugated with a Cell-Penetrating Peptide. Journal of medicinal chemistry 67 (2) (2024)
Fabian B H Rehm, Tristan J Tyler, Yan Zhou, Yen-Hua Huang, Conan K Wang, Nicole Lawrence, David J Craik, Thomas Durek
Repurposing a plant peptide cyclase for targeted lysine acylation. Nature chemistry (2024)
Biswajit Biswas, Yen-Hua Huang, David J Craik, Conan K Wang
The prospect of substrate-based kinase inhibitors to improve target selectivity and overcome drug resistance. Chemical science 15 (33) (2024)
Fabian B H Rehm, Tristan J Tyler, Yan Zhou, Yen-Hua Huang, Conan K Wang, Nicole Lawrence, David J Craik, Thomas Durek
Author Correction: Repurposing a plant peptide cyclase for targeted lysine acylation. Nature chemistry (2024)
Negin Khatibi, Yen-Hua Huang, Conan K Wang, Thomas Durek, Edward K Gilding, David J Craik
Isolation and Characterization of Insecticidal Cyclotides from Viola communis . Journal of natural products (2024)
Grégoire Jean-Baptiste Philippe, Yen-Hua Huang, Anna Mittermeier, Christopher J Brown, Quentin Kaas, Siti Radhiah Ramlan, Conan K Wang, David Lane, Alexander Loewer, Sónia Troeira Henriques, David J Craik
Delivery to, and Reactivation of, the p53 Pathway in Cancer Cells Using a Grafted Cyclotide Conjugated with a Cell-Penetrating Peptide. Journal of medicinal chemistry 67 (2) (2024)
Zhihao Jiang, Yen-Hua Huang, Quentin Kaas, David J Craik, Conan K Wang
Structure and Activity of Reconstructed Pseudo-Ancestral Cyclotides. ChemMedChem 19 (14) (2024)
Biswajit Biswas, Yen-Hua Huang, David J Craik, Conan K Wang
The prospect of substrate-based kinase inhibitors to improve target selectivity and overcome drug resistance. Chemical science 15 (33) (2024)
Zhian Chen, Yanfang Cui, Yin Yao, Bo Liu, Joseph Yunis, Xin Gao, Naiqi Wang, Pablo F Cañete, Zewen Kelvin Tuong, Hongjian Sun, Hao Wang, Si-Ling Yang, Runli Wang, Yew Ann Leong, David Simon Davis, Jiahuan Qin, Kaili Liang, Jun Deng, Conan K Wang, Yen-Hua Huang, Jonathan A Roco, Sam Nettelfield, Huaming Zhu, Huajun Xu, Zhijia Yu, David J Craik, Zheng Liu, Hai Qi, Christopher R Parish, Di Yu
Heparan sulfate regulates IL-21 bioavailability and signal strength that control germinal center B cell selection and differentiation. Science immunology 8 (80) (2023)
Zhian Chen, Yanfang Cui, Yin Yao, Bo Liu, Joseph Yunis, Xin Gao, Naiqi Wang, Pablo F Cañete, Zewen Kelvin Tuong, Hongjian Sun, Hao Wang, Si-Ling Yang, Runli Wang, Yew Ann Leong, David Simon Davis, Jiahuan Qin, Kaili Liang, Jun Deng, Conan K Wang, Yen-Hua Huang, Jonathan A Roco, Sam Nettelfield, Huaming Zhu, Huajun Xu, Zhijia Yu, David J Craik, Zheng Liu, Hai Qi, Christopher R Parish, Di Yu
Heparan sulfate regulates IL-21 bioavailability and signal strength that control germinal center B cell selection and differentiation. Science immunology 8 (80) (2023)
Abhishek Bajpai, Mark A Jackson, Yen-Hua Huang, Kuok Yap, Qingdan Du, Tevin Chui-Ying Chau, David J Craik, Edward K Gilding
Nematicidal Activity of Cyclotides: Toxicity Against Caenorhabditis elegans . Journal of natural products (2023)
Zhian Chen, Yanfang Cui, Yin Yao, Bo Liu, Joseph Yunis, Xin Gao, Naiqi Wang, Pablo F Cañete, Zewen Kelvin Tuong, Hongjian Sun, Hao Wang, Si-Ling Yang, Runli Wang, Yew Ann Leong, David Simon Davis, Jiahuan Qin, Kaili Liang, Jun Deng, Conan K Wang, Yen-Hua Huang, Jonathan A Roco, Sam Nettelfield, Huaming Zhu, Huajun Xu, Zhijia Yu, David J Craik, Zheng Liu, Hai Qi, Christopher R Parish, Di Yu
Heparan sulfate regulates IL-21 bioavailability and signal strength that control germinal center B cell selection and differentiation. Science immunology 8 (80) (2023)
Zhian Chen, Yanfang Cui, Yin Yao, Bo Liu, Joseph Yunis, Xin Gao, Naiqi Wang, Pablo F Cañete, Zewen Kelvin Tuong, Hongjian Sun, Hao Wang, Si-Ling Yang, Runli Wang, Yew Ann Leong, David Simon Davis, Jiahuan Qin, Kaili Liang, Jun Deng, Conan K Wang, Yen-Hua Huang, Jonathan A Roco, Sam Nettelfield, Huaming Zhu, Huajun Xu, Zhijia Yu, David J Craik, Zheng Liu, Hai Qi, Christopher R Parish, Di Yu
Heparan sulfate regulates IL-21 bioavailability and signal strength that control germinal center B cell selection and differentiation. Science immunology 8 (80) (2023)
Yuhui Zhang, Li Wang, Benjamin J Tombling, Carmen Lammi, Yen-Hua Huang, Yue Li, Martina Bartolomei, Bin Hong, David J Craik, Conan K Wang
Improving Stability Enhances In Vivo Efficacy of a PCSK9 Inhibitory Peptide. Journal of the American Chemical Society 144 (42) (2022)
Yue Wu, Zhenling Cui, Yen-Hua Huang, Simon J de Veer, Mikhail S Baranov, Zhong Guo, Shayli V Moradi, Alexandra O Hinton, Jennifer R Deuis, Shaodong Guo, Kai-En Chen, Brett M Collins, Irina Vetter, Volker Herzig, Alun Jones, Matthew A Cooper, Glenn F King, David J Craik, Kirill Alexandrov, Sergey Mureev
Towards a generic prototyping approach for therapeutically-relevant peptides and proteins in a cell-free translation system. Nature communications 13 (1) (2022)
Grégoire Jean-Baptiste Philippe, Anna Mittermeier, Nicole Lawrence, Yen-Hua Huang, Nicholas D Condon, Alexander Loewer, David J Craik, Sónia Troeira Henriques
Angler Peptides: Macrocyclic Conjugates Inhibit p53:MDM2/X Interactions and Activate Apoptosis in Cancer Cells. ACS chemical biology 16 (2) (2021)
Huawu Yin, Yen-Hua Huang, Sarah A Best, Kate D Sutherland, David J Craik, Conan K Wang
An Integrated Molecular Grafting Approach for the Design of Keap1-Targeted Peptide Inhibitors. ACS chemical biology 16 (7) (2021)
Yen-Hua Huang, Qingdan Du, Zhihao Jiang, Gordon J King, Brett M Collins, Conan K Wang, David J Craik
Enabling Efficient Folding and High-Resolution Crystallographic Analysis of Bracelet Cyclotides. Molecules (Basel, Switzerland) 26 (18) (2021)
Huawu Yin, Xiuman Zhou, Yen-Hua Huang, Gordon J King, Brett M Collins, Yanfeng Gao, David J Craik, Conan K Wang
Rational Design of Potent Peptide Inhibitors of the PD-1:PD-L1 Interaction for Cancer Immunotherapy. Journal of the American Chemical Society 143 (44) (2021)
Wenyu Liu, Simon J de Veer, Yen-Hua Huang, Toru Sengoku, Chikako Okada, Kazuhiro Ogata, Christina N Zdenek, Bryan G Fry, Joakim E Swedberg, Toby Passioura, David J Craik, Hiroaki Suga
An Ultrapotent and Selective Cyclic Peptide Inhibitor of Human β-Factor XIIa in a Cyclotide Scaffold. Journal of the American Chemical Society 143 (44) (2021)
Bronwyn J Smithies, Yen-Hua Huang, Mark A Jackson, Kuok Yap, Edward K Gilding, Karen S Harris, Marilyn A Anderson, David J Craik
Circular Permutation of the Native Enzyme-Mediated Cyclization Position in Cyclotides. ACS chemical biology 15 (4) (2020)
Tien T Dang, Lai Yue Chan, Yen-Hua Huang, Linh T T Nguyen, Quentin Kaas, Tien T Huynh, David J Craik
Exploring the Sequence Diversity of Cyclotides from Vietnamese Viola Species. Journal of natural products 83 (6) (2020)
Qingdan Du, Yen-Hua Huang, Abhishek Bajpai, Majbrit Frosig-Jorgensen, Guangzu Zhao, David J Craik
Evaluation of the in Vivo Aphrodisiac Activity of a Cyclotide Extract from Hybanthus enneaspermus. Journal of natural products 83 (12) (2020)
Ri-Lei Yu, Jiayi Wang, Lok-Yan So, Peta J Harvey, Juan Shi, Jiazhen Liang, Qin Dou, Xiao Li, Xiayi Yan, Yen-Hua Huang, Qingliang Xu, Quentin Kaas, Ho-Yin Chow, Kwok-Yin Wong, David J Craik, Xiao-Hua Zhang, Tao Jiang, Yan Wang
Enhanced Activity against Multidrug-Resistant Bacteria through Coapplication of an Analogue of Tachyplesin I and an Inhibitor of the QseC/B Signaling Pathway. Journal of medicinal chemistry 63 (7) (2020)
Huawu Yin, Yen-Hua Huang, Kirsten Deprey, Nicholas D Condon, Joshua A Kritzer, David J Craik, Conan K Wang
Cellular Uptake and Cytosolic Delivery of a Cyclic Cystine Knot Scaffold. ACS chemical biology 15 (6) (2020)
Qingdan Du, Lai Yue Chan, Edward K Gilding, Sónia Troeira Henriques, Nicholas D Condon, Anjaneya S Ravipati, Quentin Kaas, Yen-Hua Huang, David J Craik
Discovery and mechanistic studies of cytotoxic cyclotides from the medicinal herb Hybanthus enneaspermus. The Journal of biological chemistry 295 (32) (2020)
Felicitas Vernen, Peta J Harvey, Susana A Dias, Ana Salomé Veiga, Yen-Hua Huang, David J Craik, Nicole Lawrence, Sónia Troeira Henriques
Characterization of Tachyplesin Peptides and Their Cyclized Analogues to Improve Antimicrobial and Anticancer Properties. International journal of molecular sciences 20 (17) (2019)
Grégoire J-B Philippe, Diana Gaspar, Caibin Sheng, Yen-Hua Huang, Aurélie H Benfield, Nicholas D Condon, Joachim Weidmann, Nicole Lawrence, Alexander Löwer, Miguel A R B Castanho, David J Craik, Sónia Troeira Henriques
Cell Membrane Composition Drives Selectivity and Toxicity of Designed Cyclic Helix-Loop-Helix Peptides with Cell Penetrating and Tumor Suppressor Properties. ACS chemical biology 14 (9) (2019)
Suelem D Ramalho, Conan K Wang, Gordon J King, Karl A Byriel, Yen-Hua Huang, Vanderlan da Silva Bolzani, David J Craik
Synthesis, Racemic X-ray Crystallographic, and Permeability Studies of Bioactive Orbitides from Jatropha Species. Journal of natural products 81 (11) (2018)
Xiaosa Wu, Yen-Hua Huang, Quentin Kaas, Peta J Harvey, Conan K Wang, Han-Shen Tae, David J Adams, David J Craik
Backbone cyclization of analgesic conotoxin GeXIVA facilitates direct folding of the ribbon isomer. The Journal of biological chemistry 292 (41) (2017)