David Crich

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 78

Top Topics

Molecular Dynamics Simulations

Crystal Structure

Top Venues

The Journal of organic chemistry

Journal of the American Chemical Society

ACS infectious diseases

Organic letters

This page only lists publications with an associated author ORCID identifier.

Publications

Niteshlal Kasdekar, Michael R Spieker, David Crich
Practical Synthesis from Streptomycin and Regioselective Partial Deprotections of (-)-(1 R ,2 S ,3 R ,4 R ,5 S ,6 S )-1,3-Di(deamino)-1,3-diazido-2,5,6-tri- O -benzylstreptamine. The Journal of organic chemistry 89 (6) (2024)
Niteshlal Kasdekar, Michael R Spieker, David Crich
Practical Synthesis from Streptomycin and Regioselective Partial Deprotections of (-)-(1 R ,2 S ,3 R ,4 R ,5 S ,6 S )-1,3-Di(deamino)-1,3-diazido-2,5,6-tri- O -benzylstreptamine. The Journal of organic chemistry (2024)
Jarvis Hill, R Houston Givhan, Bin Yi, Robert M Jones, Eugene F Douglass, Yaguang Xi, Henry F Schaefer, David Crich
Computationally Driven Discovery of a BCR-ABL1 Kinase Inhibitor with Activity in Multidrug-Resistant Chronic Myeloid Leukemia. Journal of medicinal chemistry (2024)
Sonja Gross, Sebastian Herren, Marina Gysin, Anna Rominski, Anna Roditscheff, Martin Risch, Frank Imkamp, David Crich, Sven N Hobbie
In vitro susceptibility of Neisseria gonorrhoeae to netilmicin and etimicin in comparison to gentamicin and other aminoglycosides. European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 43 (5) (2024)
Niteshlal Kasdekar, Michael R Spieker, David Crich
Practical Synthesis from Streptomycin and Regioselective Partial Deprotections of (-)-(1 R ,2 S ,3 R ,4 R ,5 S ,6 S )-1,3-Di(deamino)-1,3-diazido-2,5,6-tri- O -benzylstreptamine. The Journal of organic chemistry 89 (6) (2024)
Sonja Gross, Sebastian Herren, Marina Gysin, Anna Rominski, Anna Roditscheff, Martin Risch, Frank Imkamp, David Crich, Sven N Hobbie
In vitro susceptibility of Neisseria gonorrhoeae to netilmicin and etimicin in comparison to gentamicin and other aminoglycosides. European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 43 (5) (2024)
Niteshlal Kasdekar, Michael R Spieker, David Crich
Practical Synthesis from Streptomycin and Regioselective Partial Deprotections of (-)-(1 R ,2 S ,3 R ,4 R ,5 S ,6 S )-1,3-Di(deamino)-1,3-diazido-2,5,6-tri- O -benzylstreptamine. The Journal of organic chemistry 89 (6) (2024)
Niteshlal Kasdekar, Michael R Spieker, David Crich
Practical Synthesis from Streptomycin and Regioselective Partial Deprotections of (-)-(1 R ,2 S ,3 R ,4 R ,5 S ,6 S )-1,3-Di(deamino)-1,3-diazido-2,5,6-tri- O -benzylstreptamine. The Journal of organic chemistry 89 (6) (2024)
Sonja Gross, Sebastian Herren, Marina Gysin, Anna Rominski, Anna Roditscheff, Martin Risch, Frank Imkamp, David Crich, Sven N Hobbie
In vitro susceptibility of Neisseria gonorrhoeae to netilmicin and etimicin in comparison to gentamicin and other aminoglycosides. European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 43 (5) (2024)
Sonja Gross, Sebastian Herren, Marina Gysin, Anna Rominski, Anna Roditscheff, Martin Risch, Frank Imkamp, David Crich, Sven N Hobbie
In vitro susceptibility of Neisseria gonorrhoeae to netilmicin and etimicin in comparison to gentamicin and other aminoglycosides. European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology (2024)
Niteshlal Kasdekar, Michael R Spieker, David Crich
Practical Synthesis from Streptomycin and Regioselective Partial Deprotections of (-)-(1 R ,2 S ,3 R ,4 R ,5 S ,6 S )-1,3-Di(deamino)-1,3-diazido-2,5,6-tri- O -benzylstreptamine. The Journal of organic chemistry 89 (6) (2024)
Ruslans Muhamadejevs, Klara Haldimann, Marina Gysin, David Crich, Kristaps Jaudzems, Sven N Hobbie
Experimental Determination of the p K a Values of Clinically Relevant Aminoglycoside Antibiotics: Toward Establishing p K a -Activity Relationships. ACS omega 9 (5) (2024)
Po-Sen Tseng, Chennaiah Ande, Kelley W Moremen, David Crich
Influence of Side Chain Conformation on the Activity of Glycosidase Inhibitors. Angewandte Chemie (International ed. in English) 62 (8) (2023)
Santanu Jana, Parasuraman Rajasekaran, Klara Haldimann, Andrea Vasella, Erik C Böttger, Sven N Hobbie, David Crich
Synthesis of Gentamicins C1, C2, and C2a and Antiribosomal and Antibacterial Activity of Gentamicins B1, C1, C1a, C2, C2a, C2b, and X2. ACS infectious diseases (2023)
Kapil Upadhyaya, Nicolas Osorio-Morales, David Crich
Can Side-Chain Conformation and Glycosylation Selectivity of Hexopyranosyl Donors Be Controlled with a Dummy Ligand? The Journal of organic chemistry (2023)
Po-Sen Tseng, Chennaiah Ande, Kelley W Moremen, David Crich
Influence of Side Chain Conformation on the Activity of Glycosidase Inhibitors. Angewandte Chemie (International ed. in English) 62 (8) (2023)
Po-Sen Tseng, Chennaiah Ande, Kelley W Moremen, David Crich
Influence of Side Chain Conformation on the Activity of Glycosidase Inhibitors. Angewandte Chemie (International ed. in English) 62 (8) (2023)
Jarvis Hill, Robert M Jones, David Crich
Atypical N -Alkyl to N -Noralkoxy Switch in a Dual cSRC/BCR-ABL1 Kinase Inhibitor Improves Drug Efflux and hERG Affinity. ACS medicinal chemistry letters 14 (12) (2023)
Jarvis Hill, Thomas D Beckler, David Crich
Recent Advances in the Synthesis of Di- and Trisubstituted Hydroxylamines. Molecules (Basel, Switzerland) 28 (6) (2023)
Jarvis Hill, Robert M Jones, David Crich
Discovery of a Hydroxylamine-Based Brain-Penetrant EGFR Inhibitor for Metastatic Non-Small-Cell Lung Cancer. Journal of medicinal chemistry (2023)
Chennaiah Ande, David Crich
Stereodirecting Effect of Esters at the 4-Position of Galacto- and Glucopyranosyl Donors: Effect of 4- C -Methylation on Side-Chain Conformation and Donor Reactivity, and Influence of Concentration and Stoichiometry on Distal Group Participation. The Journal of organic chemistry (2023)
Jarvis Hill, Robert M Jones, David Crich
Atypical N -Alkyl to N -Noralkoxy Switch in a Dual cSRC/BCR-ABL1 Kinase Inhibitor Improves Drug Efflux and hERG Affinity. ACS medicinal chemistry letters 14 (12) (2023)
Jarvis Hill, Thomas D Beckler, David Crich
Recent Advances in the Synthesis of Di- and Trisubstituted Hydroxylamines. Molecules (Basel, Switzerland) 28 (6) (2023)
Kapil Upadhyaya, Nicolas Osorio-Morales, David Crich
Can Side-Chain Conformation and Glycosylation Selectivity of Hexopyranosyl Donors Be Controlled with a Dummy Ligand? The Journal of organic chemistry 88 (6) (2023)
Kapil Upadhyaya, Nicolas Osorio-Morales, David Crich
Can Side-Chain Conformation and Glycosylation Selectivity of Hexopyranosyl Donors Be Controlled with a Dummy Ligand? The Journal of organic chemistry 88 (6) (2023)
Kapil Upadhyaya, Nicolas Osorio-Morales, David Crich
Can Side-Chain Conformation and Glycosylation Selectivity of Hexopyranosyl Donors Be Controlled with a Dummy Ligand? The Journal of organic chemistry 88 (6) (2023)
Jarvis Hill, Thomas D Beckler, David Crich
Recent Advances in the Synthesis of Di- and Trisubstituted Hydroxylamines. Molecules (Basel, Switzerland) 28 (6) (2023)
Kapil Upadhyaya, Nicolas Osorio-Morales, David Crich
Can Side-Chain Conformation and Glycosylation Selectivity of Hexopyranosyl Donors Be Controlled with a Dummy Ligand? The Journal of organic chemistry 88 (6) (2023)
Po-Sen Tseng, Chennaiah Ande, Kelley W Moremen, David Crich
Influence of Side Chain Conformation on the Activity of Glycosidase Inhibitors. Angewandte Chemie (International ed. in English) 62 (8) (2023)
Jarvis Hill, David Crich
The N,N,O -Trisubstituted Hydroxylamine Isostere and Its Influence on Lipophilicity and Related Parameters. ACS medicinal chemistry letters 13 (5) (2022)
Timothy F McMillan, David Crich
Influence of 3-Thio Substituents on Benzylidene-Directed Mannosylation. Isolation of a Bridged Pyridinium Ion and Effects of 3- O -Picolyl and 3- S -Picolyl Esters. European journal of organic chemistry 2022 (20) (2022)
Po-Sen Tseng, Chennaiah Ande, Kelley W Moremen, David Crich
Influence of Side Chain Conformation on the Activity of Glycosidase Inhibitors. Angewandte Chemie (International ed. in English) (2022)
Brendan T Freitas, Daniil A Ahiadorme, Rahul S Bagul, Ian A Durie, Samir Ghosh, Jarvis Hill, Naomi E Kramer, Jackelyn Murray, Brady M O'Boyle, Emmanuel Onobun, Michael G Pirrone, Justin D Shepard, Suzanne Enos, Yagya P Subedi, Kapil Upadhyaya, Ralph A Tripp, Brian S Cummings, David Crich, Scott D Pegan
Exploring Noncovalent Protease Inhibitors for the Treatment of Severe Acute Respiratory Syndrome and Severe Acute Respiratory Syndrome-Like Coronaviruses. ACS infectious diseases 8 (3) (2022)
Michael G Pirrone, Chennaiah Ande, Klara Haldimann, Sven N Hobbie, Andrea Vasella, Erik C Böttger, David Crich
Importance of Co-operative Hydrogen Bonding in the Apramycin-Ribosomal Decoding A-Site Interaction. ChemMedChem (2022)
Kapil Upadhyaya, David Crich
Synthesis of 10-Aza-9-oxakalkitoxin by N-O Bond Formation. Organic letters 24 (9) (2022)
Sameera Siyabalapitiya Arachchige, David Crich
Syntheses of Legionaminic Acid, Pseudaminic Acid, Acetaminic Acid, 8- epi -Acetaminic Acid, and 8- epi -Legionaminic Acid Glycosyl Donors from N -Acetylneuraminic Acid by Side Chain Exchange. Organic letters 24 (16) (2022)
Jonathan C K Quirke, Girish C Sati, Amr Sonousi, Marina Gysin, Klara Haldimann, Erik C Böttger, Andrea Vasella, Sven N Hobbie, David Crich
Structure-Activity Relationships for 5'' Modifications of 4,5-Aminoglycoside Antibiotics. ChemMedChem 17 (13) (2022)
Santanu Jana, David Crich
Synthesis of Gentamicin Minor Components: Gentamicin C1a and Gentamicin C2b. Organic letters 24 (46) (2022)
Sameera Siyabalapitiya Arachchige, David Crich
Side Chain Conformation and Its Influence on Glycosylation Selectivity in Hexo- and Higher Carbon Furanosides. The Journal of organic chemistry 87 (1) (2021)
Peter R Andreana, David Crich
Guidelines for O-Glycoside Formation from First Principles. ACS central science 7 (9) (2021)
Kapil Upadhyaya, Rahul S Bagul, David Crich
Influence of Configuration at the 4- and 6-Positions on the Conformation and Anomeric Reactivity and Selectivity of 7-Deoxyheptopyranosyl Donors: Discovery of a Highly Equatorially Selective l-glycero-d-gluco-Heptopyranosyl Donor. The Journal of organic chemistry 86 (17) (2021)
Michael G Pirrone, Sven N Hobbie, Andrea Vasella, Erik C Böttger, David Crich
Influence of ring size in conformationally restricted ring I analogs of paromomycin on antiribosomal and antibacterial activity. RSC medicinal chemistry 12 (9) (2021)
Kapil Upadhyaya, Yagya P Subedi, David Crich
Direct Experimental Characterization of a Bridged Bicyclic Glycosyl Dioxacarbenium Ion by 1 H and 13 C NMR Spectroscopy: Importance of Conformation on Participation by Distal Esters. Angewandte Chemie (International ed. in English) 60 (48) (2021)
Dimitrijs Lubriks, Rimants Zogota, Vikram A Sarpe, Takahiko Matsushita, Girish C Sati, Klara Haldimann, Marina Gysin, Erik C Böttger, Andrea Vasella, Edgars Suna, Sven N Hobbie, David Crich
Synthesis and Antibacterial Activity of Propylamycin Derivatives Functionalized at the 5''- and Other Positions with a View to Overcoming Resistance Due to Aminoglycoside Modifying Enzymes. ACS infectious diseases 7 (8) (2021)
Jarvis Hill, David Crich
Synthesis of O-tert-Butyl-N,N-disubstituted Hydroxylamines by N-O Bond Formation. Organic letters 23 (16) (2021)
Michael G Pirrone, Marina Gysin, Klara Haldimann, Sven N Hobbie, Andrea Vasella, David Crich
Predictive Analysis of the Side Chain Conformation of the Higher Carbon Sugars: Application to the Preorganization of the Aminoglycoside Ring 1 Side Chain for Binding to the Bacterial Ribosomal Decoding A Site. The Journal of organic chemistry 85 (24) (2020)
David Crich
En Route to the Transformation of Glycoscience: A Chemist's Perspective on Internal and External Crossroads in Glycochemistry. Journal of the American Chemical Society 143 (1) (2020)
Emmanuel Onobun, David Crich
Synthesis of 3-Deoxy-d-manno-oct-2-ulosonic Acid (KDO) and Pseudaminic Acid C-Glycosides. The Journal of organic chemistry 85 (24) (2020)
Parasuraman Rajasekaran, David Crich
Synthesis of Gentamicin Minor Components: Gentamicin B1 and Gentamicin X2. Organic letters 22 (10) (2020)
Brendan T Freitas, Ian A Durie, Jackelyn Murray, Jaron E Longo, Holden C Miller, David Crich, Robert Jeff Hogan, Ralph A Tripp, Scott D Pegan
Characterization and Noncovalent Inhibition of the Deubiquitinase and deISGylase Activity of SARS-CoV-2 Papain-Like Protease. ACS infectious diseases 6 (8) (2020)
Asiri A Hettikankanamalage, Robert Lassfolk, Filip S Ekholm, Reko Leino, David Crich
Mechanisms of Stereodirecting Participation and Ester Migration from Near and Far in Glycosylation and Related Reactions. Chemical reviews 120 (15) (2020)
Amr Sonousi, Andrea Vasella, David Crich
Synthesis of a Pseudodisaccharide Suitable for Synthesis of Ring I Modified 4,5-2-Deoxystreptamine Type Aminoglycoside Antibiotics. The Journal of organic chemistry 85 (11) (2020)
Sandeep Dhanju, Kapil Upadhyaya, Christopher A Rice, Scott D Pegan, Joseph Media, Frederick A Valeriote, David Crich
Synthesis, Cytotoxicity, and Genotoxicity of 10-Aza-9-oxakalkitoxin, an N,N,O-Trisubstituted Hydroxylamine Analog, or Hydroxalog, of a Marine Natural Product. Journal of the American Chemical Society 142 (20) (2020)
Jarvis Hill, Asiri A Hettikankanamalage, David Crich
Diversity-Oriented Synthesis of N,N,O-Trisubstituted Hydroxylamines from Alcohols and Amines by N-O Bond Formation. Journal of the American Chemical Society 142 (35) (2020)
Philemon Ngoje, David Crich
Stereocontrolled Synthesis of the Equatorial Glycosides of 3-Deoxy-d-manno-oct-2-ulosonic Acid: Role of Side Chain Conformation. Journal of the American Chemical Society 142 (17) (2020)
Amr Sonousi, Jonathan C K Quirke, Prabuddha Waduge, Tanja Janusic, Marina Gysin, Klara Haldimann, Shan Xu, Sven N Hobbie, Su-Hua Sha, Jochen Schacht, Christine S Chow, Andrea Vasella, Erik C Böttger, David Crich
An Advanced Apralog with Increased in vitro and in vivo Activity toward Gram-negative Pathogens and Reduced ex vivo Cochleotoxicity. ChemMedChem 16 (2) (2020)
Jonathan C K Quirke, David Crich
Glycoside Hydrolases Restrict the Side Chain Conformation of Their Substrates To Gain Additional Transition State Stabilization. Journal of the American Chemical Society 142 (40) (2020)
Amr Sonousi, Dimitri Shcherbakov, Andrea Vasella, Erik C Böttger, David Crich
Synthesis, ribosomal selectivity, and antibacterial activity of netilmicin 4'-derivatives. MedChemComm 10 (6) (2019)
Mohammed Hawsawi, Anura Wickramasinghe, David Crich
Use of Phenols as Nucleophiles in the Zbiral Oxidative Deamination of N-Acetyl Neuraminic Acid: Isolation and Characterization of Tricyclic 3-Keto-2-deoxy-nonulosonic Acid (KDN) Derivatives via an Intermediate Vinyl Diazonium Ion. The Journal of organic chemistry 84 (22) (2019)
Girish C Sati, Vikram A Sarpe, Takayuki Furukawa, Sujit Mondal, Matilde Mantovani, Sven N Hobbie, Andrea Vasella, Erik C Böttger, David Crich
Modification at the 2'-Position of the 4,5-Series of 2-Deoxystreptamine Aminoglycoside Antibiotics To Resist Aminoglycoside Modifying Enzymes and Increase Ribosomal Target Selectivity. ACS infectious diseases 5 (10) (2019)
Jonathan C K Quirke, Parasuraman Rajasekaran, Vikram A Sarpe, Amr Sonousi, Ivan Osinnii, Marina Gysin, Klara Haldimann, Qiao-Jun Fang, Dimitri Shcherbakov, Sven N Hobbie, Su-Hua Sha, Jochen Schacht, Andrea Vasella, Erik C Böttger, David Crich
Apralogs: Apramycin 5-O-Glycosides and Ethers with Improved Antibacterial Activity and Ribosomal Selectivity and Reduced Susceptibility to the Aminoacyltranserferase (3)-IV Resistance Determinant. Journal of the American Chemical Society 142 (1) (2019)
Vikram A Sarpe, Michael G Pirrone, Klara Haldimann, Sven N Hobbie, Andrea Vasella, David Crich
Synthesis of saccharocin from apramycin and evaluation of its ribosomal selectivity. MedChemComm 10 (4) (2019)
Erik C Böttger, David Crich
Aminoglycosides: Time for the Resurrection of a Neglected Class of Antibacterials? ACS infectious diseases 6 (2) (2019)
Philemon Ngoje, David Crich
Synthesis of Bradyrhizose from d-Glucose. Organic letters 22 (2) (2019)
Takahiko Matsushita, Girish C Sati, Nuwan Kondasinghe, Michael G Pirrone, Takayuki Kato, Prabuddha Waduge, Harshitha Santhosh Kumar, Adrian Cortes Sanchon, Malgorzata Dobosz-Bartoszek, Dimitri Shcherbakov, Mario Juhas, Sven N Hobbie, Thomas Schrepfer, Christine S Chow, Yury S Polikanov, Jochen Schacht, Andrea Vasella, Erik C Böttger, David Crich
Design, Multigram Synthesis, and in Vitro and in Vivo Evaluation of Propylamycin: A Semisynthetic 4,5-Deoxystreptamine Class Aminoglycoside for the Treatment of Drug-Resistant Enterobacteriaceae and Other Gram-Negative Pathogens. Journal of the American Chemical Society 141 (12) (2019)
Peng Wen, Václav Větvička, David Crich
Synthesis and Evaluation of Oligomeric Thioether-Linked Carbacyclic β-(1→3)-Glucan Mimetics. The Journal of organic chemistry 84 (9) (2019)
Xiaoxiao Liao, Václav Větvička, David Crich
Synthesis and Evaluation of 1,5-Dithia-d-laminaribiose, Triose, and Tetraose as Truncated β-(1→3)-Glucan Mimetics. The Journal of organic chemistry 83 (24) (2018)
Suresh Dharuman, Harsha Amarasekara, David Crich
Interplay of Protecting Groups and Side Chain Conformation in Glycopyranosides. Modulation of the Influence of Remote Substituents on Glycosylation? The Journal of organic chemistry 83 (17) (2018)
Harsha Amarasekara, Suresh Dharuman, Takayuki Kato, David Crich
Synthesis of Conformationally-Locked cis- and trans-Bicyclo[4.4.0] Mono-, Di-, and Trioxadecane Modifications of Galacto- and Glucopyranose; Experimental Limiting 3JH,H Coupling Constants for the Estimation of Carbohydrate Side Chain Populations and Beyond. The Journal of organic chemistry 83 (2) (2018)
Bibek Dhakal, David Crich
Synthesis and Stereocontrolled Equatorially Selective Glycosylation Reactions of a Pseudaminic Acid Donor: Importance of the Side-Chain Conformation and Regioselective Reduction of Azide Protecting Groups. Journal of the American Chemical Society 140 (44) (2018)
Philip Ouma Adero, Harsha Amarasekara, Peng Wen, Luis Bohé, David Crich
The Experimental Evidence in Support of Glycosylation Mechanisms at the SN1-SN2 Interface. Chemical reviews 118 (17) (2018)
Amr Sonousi, Vikram A Sarpe, Margarita Brilkova, Jochen Schacht, Andrea Vasella, Erik C Böttger, David Crich
Effects of the 1- N-(4-Amino-2 S-hydroxybutyryl) and 6'- N-(2-Hydroxyethyl) Substituents on Ribosomal Selectivity, Cochleotoxicity, and Antibacterial Activity in the Sisomicin Class of Aminoglycoside Antibiotics. ACS infectious diseases 4 (7) (2018)
Oskar Popik, Bibek Dhakal, David Crich
Stereoselective Synthesis of the Equatorial Glycosides of Legionaminic Acid. The Journal of organic chemistry 82 (12) (2017)
Bibek Dhakal, Luis Bohé, David Crich
Trifluoromethanesulfonate Anion as Nucleophile in Organic Chemistry. The Journal of organic chemistry 82 (18) (2017)
Sandeep Dhanju, Brendan W Blazejewski, David Crich
Synthesis of Trialkylhydroxylamines by Stepwise Reduction of O-Acyl N,N-Disubstituted Hydroxylamines: Substituent Effects on the Reduction of O-(1-Acyloxyalkyl)hydroxylamines and on the Conformational Dynamics of N-Alkoxypiperidines. The Journal of organic chemistry 82 (10) (2017)
Appi Reddy Mandhapati, Guanyu Yang, Takayuki Kato, Dimitri Shcherbakov, Sven N Hobbie, Andrea Vasella, Erik C Böttger, David Crich
Structure-Based Design and Synthesis of Apramycin-Paromomycin Analogues: Importance of the Configuration at the 6'-Position and Differences between the 6'-Amino and Hydroxy Series. Journal of the American Chemical Society 139 (41) (2017)
Girish C Sati, Dimitri Shcherbakov, Sven N Hobbie, Andrea Vasella, Erik C Böttger, David Crich
N6', N6''', and O4' Modifications to Neomycin Affect Ribosomal Selectivity without Compromising Antibacterial Activity. ACS infectious diseases 3 (5) (2017)
Peng Wen, David Crich
Blue Light Photocatalytic Glycosylation without Electrophilic Additives. Organic letters 19 (9) (2017)