David J Brockwell (D J Brockwell)

Scopus Author ID ORCID

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 35

Top Venues

Proceedings of the National Academy of Sciences of the United States of America

Nature communications

Science (New York, N.Y.)

Protein science : a publication of the Protein Society

University of Leeds Faculty of Biological Sciences

University of Manchester (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

University of Leeds Faculty of Biological Sciences

United Kingdom

Associate Professor :: School of Molecular and Cellular Biology

University of Leeds Faculty of Biological Sciences

United Kingdom

Lecturer :: School of Molecular and Cellular Biology

University of Leeds Faculty of Biological Sciences

United Kingdom

University Research Fellow. EPSRC doctoral training centre lecturer. :: School of Molecular and Cellular Biology

University of Manchester

United Kingdom

PDRA :: School of Pharmacy and Pharmaceutical Sciences

Education History

University of Manchester

United Kingdom

PHD :: School of Pharmacy and Pharmaceutical Sciences

University of Manchester

United Kingdom

BSC :: School of Pharmacy and Pharmaceutical Sciences

Publications

Samuel Berhanu, Sagardip Majumder, Thomas Müntener, James Whitehouse, Carolin Berner, Asim K Bera, Alex Kang, Binyong Liang, G Nasir Khan, Banumathi Sankaran, Lukas K Tamm, David J Brockwell, Sebastian Hiller, Sheena E Radford, Julien S Baker, Anastassia Andreevna Vorobieva
Sculpting conducting nanopore size and shape through de novo protein design. Science (New York, N.Y.) 385 (6706) (2024)
Katherine M Dewison, Benjamin Rowlinson, Jonathan M Machin, Joel A Crossley, Dev Thacker, Martin Wilkinson, Sabine M Ulamec, G Nasir Khan, Neil A Ranson, Patricija van Oosten Hawle, David J Brockwell, Sheena E Radford
Residues 2 to 7 of α-synuclein regulate amyloid formation via lipid-dependent and lipid-independent pathways. Proceedings of the National Academy of Sciences of the United States of America 121 (34) (2024)
Liam D Aubrey, Natalia N Ninkina, Sabine M Ulamec, Natalia Y Abramycheva, Eftychia Vasili, Oliver M Devine, Martin Wilkinson, Eilish Mackinnon, Galina Limorenko, Martin Walko, Sarah Muwanga, Leonardo Amadio, Owen M Peters, Sergey Nikolaevich Illarioshkin, Tiago F Outeiro, Neil A Ranson, David J Brockwell, Vladimir L Buchman, Sheena E Radford
Substitution of Met-38 to Ile in γ-synuclein found in two patients with amyotrophic lateral sclerosis induces aggregation into amyloid. Proceedings of the National Academy of Sciences of the United States of America 121 (2) (2024)
Katherine M Dewison, Benjamin Rowlinson, Jonathan M Machin, Joel A Crossley, Dev Thacker, Martin Wilkinson, Sabine M Ulamec, G Nasir Khan, Neil A Ranson, Patricija van Oosten Hawle, David J Brockwell, Sheena E Radford
Residues 2 to 7 of α-synuclein regulate amyloid formation via lipid-dependent and lipid-independent pathways. Proceedings of the National Academy of Sciences of the United States of America 121 (34) (2024)
Bob Schiffrin, Joel A Crossley, Martin Walko, Jonathan M Machin, G Nasir Khan, Iain W Manfield, Andrew J Wilson, David J Brockwell, Tomas Fessl, Antonio N Calabrese, Sheena E Radford, Anastasia Zhuravleva
Dual client binding sites in the ATP-independent chaperone SurA. Nature communications 15 (1) (2024)
Liam D Aubrey, Natalia N Ninkina, Sabine M Ulamec, Natalia Y Abramycheva, Eftychia Vasili, Oliver M Devine, Martin Wilkinson, Eilish Mackinnon, Galina Limorenko, Martin Walko, Sarah Muwanga, Leonardo Amadio, Owen M Peters, Sergey Nikolaevich Illarioshkin, Tiago F Outeiro, Neil A Ranson, David J Brockwell, Vladimir L Buchman, Sheena E Radford
Substitution of Met-38 to Ile in γ-synuclein found in two patients with amyotrophic lateral sclerosis induces aggregation into amyloid. Proceedings of the National Academy of Sciences of the United States of America 121 (2) (2024)
Katherine M Dewison, Benjamin Rowlinson, Jonathan M Machin, Joel A Crossley, Dev Thacker, Martin Wilkinson, Sabine M Ulamec, G Nasir Khan, Neil A Ranson, Patricija van Oosten Hawle, David J Brockwell, Sheena E Radford
Residues 2 to 7 of α-synuclein regulate amyloid formation via lipid-dependent and lipid-independent pathways. Proceedings of the National Academy of Sciences of the United States of America 121 (34) (2024)
Samuel Berhanu, Sagardip Majumder, Thomas Müntener, James Whitehouse, Carolin Berner, Asim K Bera, Alex Kang, Binyong Liang, G Nasir Khan, Banumathi Sankaran, Lukas K Tamm, David J Brockwell, Sebastian Hiller, Sheena E Radford, Julien S Baker, Anastassia Andreevna Vorobieva
Sculpting conducting nanopore size and shape through de novo protein design. Science (New York, N.Y.) 385 (6706) (2024)
Katherine M Dewison, Benjamin Rowlinson, Jonathan M Machin, Joel A Crossley, Dev Thacker, Martin Wilkinson, Sabine M Ulamec, G Nasir Khan, Neil A Ranson, Patricija van Oosten Hawle, David J Brockwell, Sheena E Radford
Residues 2 to 7 of α-synuclein regulate amyloid formation via lipid-dependent and lipid-independent pathways. Proceedings of the National Academy of Sciences of the United States of America 121 (34) (2024)
Liam D Aubrey, Natalia N Ninkina, Sabine M Ulamec, Natalia Y Abramycheva, Eftychia Vasili, Oliver M Devine, Martin Wilkinson, Eilish Mackinnon, Galina Limorenko, Martin Walko, Sarah Muwanga, Leonardo Amadio, Owen M Peters, Sergey Nikolaevich Illarioshkin, Tiago F Outeiro, Neil A Ranson, David J Brockwell, Vladimir L Buchman, Sheena E Radford
Substitution of Met-38 to Ile in γ-synuclein found in two patients with amyotrophic lateral sclerosis induces aggregation into amyloid. Proceedings of the National Academy of Sciences of the United States of America 121 (2) (2024)
Liam D Aubrey, Natalia N Ninkina, Sabine M Ulamec, Natalia Y Abramycheva, Eftychia Vasili, Oliver M Devine, Martin Wilkinson, Eilish Mackinnon, Galina Limorenko, Martin Walko, Sarah Muwanga, Leonardo Amadio, Owen M Peters, Sergey Nikolaevich Illarioshkin, Tiago F Outeiro, Neil A Ranson, David J Brockwell, Vladimir L Buchman, Sheena E Radford
Substitution of Met-38 to Ile in γ-synuclein found in two patients with amyotrophic lateral sclerosis induces aggregation into amyloid. Proceedings of the National Academy of Sciences of the United States of America 121 (2) (2024)
Liam D Aubrey, Natalia N Ninkina, Sabine M Ulamec, Natalia Y Abramycheva, Eftychia Vasili, Oliver M Devine, Martin Wilkinson, Eilish Mackinnon, Galina Limorenko, Martin Walko, Sarah Muwanga, Leonardo Amadio, Owen M Peters, Sergey Nikolaevich Illarioshkin, Tiago F Outeiro, Neil A Ranson, David J Brockwell, Vladimir L Buchman, Sheena E Radford
Substitution of Met-38 to Ile in γ-synuclein found in two patients with amyotrophic lateral sclerosis induces aggregation into amyloid. Proceedings of the National Academy of Sciences of the United States of America 121 (2) (2024)
Liam D Aubrey, Natalia N Ninkina, Sabine M Ulamec, Natalia Y Abramycheva, Eftychia Vasili, Oliver M Devine, Martin Wilkinson, Eilish Mackinnon, Galina Limorenko, Martin Walko, Sarah Muwanga, Leonardo Amadio, Owen M Peters, Sergey Nikolaevich Illarioshkin, Tiago F Outeiro, Neil A Ranson, David J Brockwell, Vladimir L Buchman, Sheena E Radford
Substitution of Met-38 to Ile in γ-synuclein found in two patients with amyotrophic lateral sclerosis induces aggregation into amyloid. Proceedings of the National Academy of Sciences of the United States of America 121 (2) (2024)
Liam D Aubrey, Natalia N Ninkina, Sabine M Ulamec, Natalia Y Abramycheva, Eftychia Vasili, Oliver M Devine, Martin Wilkinson, Eilish Mackinnon, Galina Limorenko, Martin Walko, Sarah Muwanga, Leonardo Amadio, Owen M Peters, Sergey Nikolaevich Illarioshkin, Tiago F Outeiro, Neil A Ranson, David J Brockwell, Vladimir L Buchman, Sheena E Radford
Substitution of Met-38 to Ile in γ-synuclein found in two patients with amyotrophic lateral sclerosis induces aggregation into amyloid. Proceedings of the National Academy of Sciences of the United States of America 121 (2) (2024)
Liam D Aubrey, Natalia N Ninkina, Sabine M Ulamec, Natalia Y Abramycheva, Eftychia Vasili, Oliver M Devine, Martin Wilkinson, Eilish Mackinnon, Galina Limorenko, Martin Walko, Sarah Muwanga, Leonardo Amadio, Owen M Peters, Sergey Nikolaevich Illarioshkin, Tiago F Outeiro, Neil A Ranson, David J Brockwell, Vladimir L Buchman, Sheena E Radford
Substitution of Met-38 to Ile in γ-synuclein found in two patients with amyotrophic lateral sclerosis induces aggregation into amyloid. Proceedings of the National Academy of Sciences of the United States of America 121 (2) (2024)
Liam D Aubrey, Natalia N Ninkina, Sabine M Ulamec, Natalia Y Abramycheva, Eftychia Vasili, Oliver M Devine, Martin Wilkinson, Eilish Mackinnon, Galina Limorenko, Martin Walko, Sarah Muwanga, Leonardo Amadio, Owen M Peters, Sergey Nikolaevich Illarioshkin, Tiago F Outeiro, Neil A Ranson, David J Brockwell, Vladimir L Buchman, Sheena E Radford
Substitution of Met-38 to Ile in γ-synuclein found in two patients with amyotrophic lateral sclerosis induces aggregation into amyloid. Proceedings of the National Academy of Sciences of the United States of America 121 (2) (2024)
Matt D G Hughes, Sophie Cussons, Benjamin S Hanson, Kalila R Cook, Tímea Feller, Najet Mahmoudi, Daniel L Baker, Robert A S Ariëns, David A Head, David J Brockwell, Lorna Dougan
Building block aspect ratio controls assembly, architecture, and mechanics of synthetic and natural protein networks. Nature communications 14 (1) (2023)
Christa P Brown, Matt D G Hughes, Najet Mahmoudi, David J Brockwell, P Louise Coletta, Sally A Peyman, Stephen D Evans, Lorna Dougan
Structural and mechanical properties of folded protein hydrogels with embedded microbubbles. Biomaterials science (2023)
Anders Aufderhorst-Roberts, Sophie Cussons, David J Brockwell, Lorna Dougan
Diversity of viscoelastic properties of an engineered muscle-inspired protein hydrogel. Soft matter (2023)
Harrison Laurent, Matt D G Hughes, Martin Walko, David J Brockwell, Najet Mahmoudi, Tristan G A Youngs, Thomas F Headen, Lorna Dougan
Visualization of Self-Assembly and Hydration of a β-Hairpin through Integrated Small and Wide-Angle Neutron Scattering. Biomacromolecules (2023)
Bob Schiffrin, Jonathan M Machin, Theodoros K Karamanos, Anastasia Zhuravleva, David J Brockwell, Sheena E Radford, Antonio N Calabrese
Dynamic interplay between the periplasmic chaperone SurA and the BAM complex in outer membrane protein folding. Communications biology 5 (1) (2022)
N Guthertz, R van der Kant, R M Martinez, Yong Xu, C Trinh, Bogdan I Iorga, F Rousseau, J Schymkowitz, David J Brockwell, S E Radford
The effect of mutation on an aggregation-prone protein: An in vivo, in vitro, and in silico analysis. Proceedings of the National Academy of Sciences of the United States of America 119 (22) (2022)
Sabine M Ulamec, Roberto Maya Martinez, Emily J Byrd, Katherine M Dewison, Yong Xu, Leon F Willis, Frank Sobott, George R Heath, Patricija van Oosten Hawle, Vladimir L Buchman, Sheena E Radford, David J Brockwell
Single residue modulators of amyloid formation in the N-terminal P1-region of α-synuclein. Nature communications 13 (1) (2022)
Paul White, Samuel F Haysom, Matthew G Iadanza, Anna J Higgins, Jonathan M Machin, James M Whitehouse, Jim E Horne, Bob Schiffrin, Charlotte Carpenter-Platt, Antonio N Calabrese, Kelly M Storek, Steven T Rutherford, David J Brockwell, Neil A Ranson, Sheena E Radford
The role of membrane destabilisation and protein dynamics in BAM catalysed OMP folding. Nature communications 12 (1) (2021)
Anastassia Andreevna Vorobieva, Paul White, Binyong Liang, Jim E Horne, Asim K Bera, Cameron M Chow, Stacey R Gerben, Sinduja K Marx, Alex Kang, Alyssa Q Stiving, Sophie R Harvey, Dagan C Marx, G Nasir Khan, Karen G Fleming, Vicki H Wysocki, David J Brockwell, Lukas K Tamm, Sheena E Radford, Julien S Baker
De novo design of transmembrane β barrels. Science (New York, N.Y.) 371 (6531) (2021)
Ciaran P A Doherty, Sabine M Ulamec, Roberto Maya-Martinez, Sarah C Good, Jemma Makepeace, G Nasir Khan, Patricija van Oosten-Hawle, Sheena E Radford, David J Brockwell
A short motif in the N-terminal region of α-synuclein is critical for both aggregation and function. Nature structural & molecular biology 27 (3) (2020)
Bob Schiffrin, Sheena E Radford, David J Brockwell, Antonio N Calabrese
PyXlinkViewer: A flexible tool for visualization of protein chemical crosslinking data within the PyMOL molecular graphics system. Protein science : a publication of the Protein Society 29 (8) (2020)
Jessica S Ebo, Janet C Saunders, Paul W A Devine, Alice M Gordon, Amy S Warwick, Bob Schiffrin, Stacey E Chin, Elizabeth England, James D Button, Christopher Lloyd, Nicholas J Bond, Alison E Ashcroft, Sheena E Radford, David C Lowe, David J Brockwell
An in vivo platform to select and evolve aggregation-resistant proteins. Nature communications 11 (1) (2020)
Antonio N Calabrese, Bob Schiffrin, Matthew Watson, Theodoros K Karamanos, Martin Walko, Julia R Humes, Jim E Horne, Paul White, Andrew J Wilson, Antreas C Kalli, Roman Tuma, Alison E Ashcroft, David J Brockwell, Sheena E Radford
Inter-domain dynamics in the chaperone SurA and multi-site binding to its outer membrane protein clients. Nature communications 11 (1) (2020)
Matthew G Iadanza, Bob Schiffrin, Paul White, Matthew A Watson, Jim E Horne, Anna J Higgins, Antonio N Calabrese, David J Brockwell, Roman Tuma, Antreas C Kalli, Sheena E Radford, Neil A Ranson
Distortion of the bilayer and dynamics of the BAM complex in lipid nanodiscs. Communications biology 3 (1) (2020)
Amit Kumar, Mohanraj Gopalswamy, Annika Wolf, David J Brockwell, Mechthild Hatzfeld, Jochen Balbach
Phosphorylation-induced unfolding regulates p19INK4d during the human cell cycle. Proceedings of the National Academy of Sciences of the United States of America 115 (13) (2018)
Leon F Willis, Amit Kumar, John Dobson, Nicholas J Bond, David Lowe, Richard Turner, Sheena E Radford, Nikil Kapur, David J Brockwell
Using extensional flow to reveal diverse aggregation landscapes for three IgG1 molecules. Biotechnology and bioengineering 115 (5) (2018)
Jim E Horne, Martin Walko, Antonio N Calabrese, Mark A Levenstein, David J Brockwell, Nikil Kapur, Andrew J Wilson, Sheena E Radford
Rapid Mapping of Protein Interactions Using Tag-Transfer Photocrosslinkers. Angewandte Chemie (International ed. in English) 57 (51) (2018)
Ciaran P A Doherty, Lydia M Young, Theodoros K Karamanos, Hugh I Smith, Matthew P Jackson, Sheena E Radford, David J Brockwell
A peptide-display protein scaffold to facilitate single molecule force studies of aggregation-prone peptides. Protein science : a publication of the Protein Society 27 (7) (2018)
John Dobson, Amit Kumar, Leon F Willis, Roman Tuma, Daniel R Higazi, Richard Turner, David C Lowe, Alison E Ashcroft, Sheena E Radford, Nikil Kapur, David J Brockwell
Inducing protein aggregation by extensional flow. Proceedings of the National Academy of Sciences of the United States of America 114 (18) (2017)

David J Brockwell.css-eqlu8i{font-size:small;padding-left:4px;} (D J Brockwell)

Publication Activity (10 Years)

Top Topics

Top Venues

David J Brockwell (D J Brockwell)