David S Eisenberg (David Eisenberg, D S Eisenberg)

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 49

Top Topics

Cognitive Decline

Multiple Myeloma

Advance Care Planning

Top Venues

Nature communications

Proceedings of the National Academy of Sciences of the United States of America

Nature structural & molecular biology

The Journal of biological chemistry

This page only lists publications with an associated author ORCID identifier.

Publications

Binh An Nguyen, Virender Singh, Shumaila Afrin, Anna Yakubovska, Lanie Wang, Yasmin Ahmed, Rose Pedretti, Maria Del Carmen Fernandez-Ramirez, Preeti Singh, Maja Pękała, Luis O Cabrera Hernandez, Siddharth Kumar, Andrew Lemoff, Román González-Prieto, Michael R Sawaya, David S Eisenberg, Merrill Douglas Benson, Lorena Saelices
Structural polymorphism of amyloid fibrils in ATTR amyloidosis revealed by cryo-electron microscopy. Nature communications 15 (1) (2024)
Binh An Nguyen, Virender Singh, Shumaila Afrin, Anna Yakubovska, Lanie Wang, Yasmin Ahmed, Rose Pedretti, Maria Del Carmen Fernandez-Ramirez, Preeti Singh, Maja Pękała, Luis O Cabrera Hernandez, Siddharth Kumar, Andrew Lemoff, Román González-Prieto, Michael R Sawaya, David S Eisenberg, Merrill Douglas Benson, Lorena Saelices
Structural polymorphism of amyloid fibrils in ATTR amyloidosis revealed by cryo-electron microscopy. Nature communications 15 (1) (2024)
David S Eisenberg, Ke Hou, Peng Ge, Michael R Sawaya, Joshua Dolinsky, Yuan Yang, Yi Xiao Jiang, Liisa Lutter, David R Boyer, Xinyi Cheng, Justin Pi, Jeffrey Zhang, Jiahui Lu, Shixin Yang, Zhiheng Yu, Juli Feigon
How short peptides can disassemble ultra-stable tau fibrils extracted from Alzheimer's disease brain by a strain-relief mechanism. Research square (2024)
Binh An Nguyen, Virender Singh, Shumaila Afrin, Anna Yakubovska, Lanie Wang, Yasmin Ahmed, Rose Pedretti, Maria Del Carmen Fernandez-Ramirez, Preeti Singh, Maja Pękała, Luis O Cabrera Hernandez, Siddharth Kumar, Andrew Lemoff, Román González-Prieto, Michael R Sawaya, David S Eisenberg, Merrill Douglas Benson, Lorena Saelices
Structural polymorphism of amyloid fibrils in ATTR amyloidosis revealed by cryo-electron microscopy. Nature communications 15 (1) (2024)
Ke Hou, Hope Pan, Hedieh Shahpasand-Kroner, Carolyn Hu, Romany Abskharon, Paul Matthew Seidler, Marisa Mekkittikul, Melinda Balbirnie, Carter Lantz, Michael R Sawaya, Joshua L Dolinsky, Mychica Jones, Xiaohong Zuo, Joseph A Loo, Sally A Frautschy, Gregory M Cole, David S Eisenberg
D-peptide-magnetic nanoparticles fragment tau fibrils and rescue behavioral deficits in a mouse model of Alzheimer's disease. Science advances 10 (18) (2024)
Binh An Nguyen, Virender Singh, Shumaila Afrin, Anna Yakubovska, Lanie Wang, Yasmin Ahmed, Rose Pedretti, Maria Del Carmen Fernandez-Ramirez, Preeti Singh, Maja Pękała, Luis O Cabrera Hernandez, Siddharth Kumar, Andrew Lemoff, Román González-Prieto, Michael R Sawaya, David S Eisenberg, Merrill Douglas Benson, Lorena Saelices
Structural polymorphism of amyloid fibrils in ATTR amyloidosis revealed by cryo-electron microscopy. Nature communications 15 (1) (2024)
Ke Hou, Hope Pan, Hedieh Shahpasand-Kroner, Carolyn Hu, Romany Abskharon, Paul Matthew Seidler, Marisa Mekkittikul, Melinda Balbirnie, Carter Lantz, Michael R Sawaya, Joshua L Dolinsky, Mychica Jones, Xiaohong Zuo, Joseph A Loo, Sally A Frautschy, Gregory M Cole, David S Eisenberg
D-peptide-magnetic nanoparticles fragment tau fibrils and rescue behavioral deficits in a mouse model of Alzheimer's disease. Science advances 10 (18) (2024)
David S Eisenberg, Ke Hou, Peng Ge, Michael R Sawaya, Joshua Dolinsky, Yuan Yang, Yi Xiao Jiang, Liisa Lutter, David R Boyer, Xinyi Cheng, Justin Pi, Jeffrey Zhang, Jiahui Lu, Shixin Yang, Zhiheng Yu, Juli Feigon
How short peptides can disassemble ultra-stable tau fibrils extracted from Alzheimer's disease brain by a strain-relief mechanism. Research square (2024)
Binh An Nguyen, Virender Singh, Shumaila Afrin, Anna Yakubovska, Lanie Wang, Yasmin Ahmed, Rose Pedretti, Maria Del Carmen Fernandez-Ramirez, Preeti Singh, Maja Pękała, Luis O Cabrera Hernandez, Siddharth Kumar, Andrew Lemoff, Román González-Prieto, Michael R Sawaya, David S Eisenberg, Merrill Douglas Benson, Lorena Saelices
Structural polymorphism of amyloid fibrils in ATTR amyloidosis revealed by cryo-electron microscopy. Nature communications 15 (1) (2024)
David S Eisenberg, Ke Hou, Peng Ge, Michael R Sawaya, Joshua Dolinsky, Yuan Yang, Yi Xiao Jiang, Liisa Lutter, David R Boyer, Xinyi Cheng, Justin Pi, Jeffrey Zhang, Jiahui Lu, Shixin Yang, Zhiheng Yu, Juli Feigon
How short peptides can disassemble ultra-stable tau fibrils extracted from Alzheimer's disease brain by a strain-relief mechanism. Research square (2024)
Kevin A Murray, Carolyn J Hu, Hope Pan, Jiahui Lu, Romany Abskharon, Jeannette T Bowler, Gregory M Rosenberg, Christopher K Williams, Gazmend Elezi, Melinda Balbirnie, Kym F Faull, Harry V Vinters, Paul M Seidler, David S Eisenberg
Small molecules disaggregate alpha-synuclein and prevent seeding from patient brain-derived fibrils. Proceedings of the National Academy of Sciences of the United States of America 120 (7) (2023)
Kevin A Murray, Carolyn J Hu, Hope Pan, Jiahui Lu, Romany Abskharon, Jeannette T Bowler, Gregory M Rosenberg, Christopher K Williams, Gazmend Elezi, Melinda Balbirnie, Kym F Faull, Harry V Vinters, Paul M Seidler, David S Eisenberg
Small molecules disaggregate alpha-synuclein and prevent seeding from patient brain-derived fibrils. Proceedings of the National Academy of Sciences of the United States of America 120 (7) (2023)
Kevin A Murray, Carolyn J Hu, Hope Pan, Jiahui Lu, Romany Abskharon, Jeannette T Bowler, Gregory M Rosenberg, Christopher K Williams, Gazmend Elezi, Melinda Balbirnie, Kym F Faull, Harry V Vinters, Paul M Seidler, David S Eisenberg
Small molecules disaggregate alpha-synuclein and prevent seeding from patient brain-derived fibrils. Proceedings of the National Academy of Sciences of the United States of America 120 (7) (2023)
Kevin A Murray, Carolyn J Hu, Hope Pan, Jiahui Lu, Romany Abskharon, Jeannette T Bowler, Gregory M Rosenberg, Christopher K Williams, Gazmend Elezi, Melinda Balbirnie, Kym F Faull, Harry V Vinters, Paul M Seidler, David S Eisenberg
Small molecules disaggregate alpha-synuclein and prevent seeding from patient brain-derived fibrils. Proceedings of the National Academy of Sciences of the United States of America 120 (7) (2023)
Einav Tayeb-Fligelman, Jeannette T Bowler, Christen E Tai, Michael R Sawaya, Yi Xiao Jiang, Gustavo Garcia, Sarah L Griner, Xinyi Cheng, Lukasz Salwinski, Liisa Lutter, Paul M Seidler, Jiahui Lu, Gregory M Rosenberg, Ke Hou, Romany Abskharon, Hope Pan, Chih-Te Zee, David R Boyer, Yan Li, Daniel H Anderson, Kevin A Murray, Genesis Falcon, Duilio Cascio, Lorena Saelices, Robert Damoiseaux, Vaithilingaraja Arumugaswami, Feng Guo, David S Eisenberg
Low complexity domains of the nucleocapsid protein of SARS-CoV-2 form amyloid fibrils. Nature communications 14 (1) (2023)
Gregory M Rosenberg, Romany Abskharon, David R Boyer, Peng Ge, Michael R Sawaya, David S Eisenberg
Fibril structures of TFG protein mutants validate the identification of TFG as a disease-related amyloid protein by the IMPAcT method. PNAS nexus 2 (12) (2023)
Kevin A Murray, Carolyn J Hu, Hope Pan, Jiahui Lu, Romany Abskharon, Jeannette T Bowler, Gregory M Rosenberg, Christopher K Williams, Gazmend Elezi, Melinda Balbirnie, Kym F Faull, Harry V Vinters, Paul M Seidler, David S Eisenberg
Small molecules disaggregate alpha-synuclein and prevent seeding from patient brain-derived fibrils. Proceedings of the National Academy of Sciences of the United States of America 120 (7) (2023)
Kevin A Murray, Carolyn J Hu, Hope Pan, Jiahui Lu, Romany Abskharon, Jeannette T Bowler, Gregory M Rosenberg, Christopher K Williams, Gazmend Elezi, Melinda Balbirnie, Kym F Faull, Harry V Vinters, Paul M Seidler, David S Eisenberg
Small molecules disaggregate alpha-synuclein and prevent seeding from patient brain-derived fibrils. Proceedings of the National Academy of Sciences of the United States of America 120 (7) (2023)
Romany Abskharon, Hope Pan, Michael R Sawaya, Paul Matthew Seidler, Eileen J Olivares, Yu Chen, Kevin A Murray, Jeffrey Zhang, Carter Lantz, Megan Bentzel, David R Boyer, Duilio Cascio, Binh A Nguyen, Ke Hou, Xinyi Cheng, Els Pardon, Christopher K Williams, Alissa L Nana, Harry V Vinters, Salvatore Spina, Lea Tenenholz Grinberg, William W Seeley, Jan Steyaert, Charles G Glabe, Rachel R Ogorzalek Loo, Joseph A Loo, David S Eisenberg
Structure-based design of nanobodies that inhibit seeding of Alzheimer's patient-extracted tau fibrils. Proceedings of the National Academy of Sciences of the United States of America 120 (41) (2023)
Einav Tayeb-Fligelman, Jeannette T Bowler, Christen E Tai, Michael R Sawaya, Yi Xiao Jiang, Gustavo Garcia, Sarah L Griner, Xinyi Cheng, Lukasz Salwinski, Liisa Lutter, Paul M Seidler, Jiahui Lu, Gregory M Rosenberg, Ke Hou, Romany Abskharon, Hope Pan, Chih-Te Zee, David R Boyer, Yan Li, Daniel H Anderson, Kevin A Murray, Genesis Falcon, Duilio Cascio, Lorena Saelices, Robert Damoiseaux, Vaithilingaraja Arumugaswami, Feng Guo, David S Eisenberg
Low complexity domains of the nucleocapsid protein of SARS-CoV-2 form amyloid fibrils. Nature communications 14 (1) (2023)
Kevin A Murray, Carolyn J Hu, Hope Pan, Jiahui Lu, Romany Abskharon, Jeannette T Bowler, Gregory M Rosenberg, Christopher K Williams, Gazmend Elezi, Melinda Balbirnie, Kym F Faull, Harry V Vinters, Paul M Seidler, David S Eisenberg
Small molecules disaggregate alpha-synuclein and prevent seeding from patient brain-derived fibrils. Proceedings of the National Academy of Sciences of the United States of America 120 (7) (2023)
Yi Xiao Jiang, Qin Cao, Michael R Sawaya, Romany Abskharon, Peng Ge, Michael DeTure, Gourisankar Ghosh, Janine Y Fu, Rachel R Ogorzalek Loo, Joseph A Loo, David S Eisenberg
Amyloid fibrils in FTLD-TDP are composed of TMEM106B and not TDP-43. Nature 605 (7909) (2022)
Kevin A Murray, Carolyn J Hu, Sarah L Griner, Hope Pan, Jeannette T Bowler, Romany Abskharon, Gregory M Rosenberg, Xinyi Cheng, Paul M Seidler, David S Eisenberg
De novo designed protein inhibitors of amyloid aggregation and seeding. Proceedings of the National Academy of Sciences of the United States of America 119 (34) (2022)
Kevin A Murray, Michael P Hughes, Carolyn J Hu, Michael R Sawaya, Lukasz Salwinski, Hope Pan, Samuel W French, Paul M Seidler, David S Eisenberg
Identifying amyloid-related diseases by mapping mutations in low-complexity protein domains to pathologies. Nature structural & molecular biology 29 (6) (2022)
Romany Abskharon, Michael R Sawaya, David R Boyer, Qin Cao, Binh A Nguyen, Duilio Cascio, David S Eisenberg
Cryo-EM structure of RNA-induced tau fibrils reveals a small C-terminal core that may nucleate fibril formation. Proceedings of the National Academy of Sciences of the United States of America 119 (15) (2022)
Paul M Seidler, Kevin A Murray, David R Boyer, Peng Ge, Michael R Sawaya, Carolyn J Hu, Xinyi Cheng, Romany Abskharon, Hope Pan, Michael A DeTure, Christopher K Williams, Gourisankar Ghosh, Harry V Vinters, David S Eisenberg
Structure-based discovery of small molecules that disaggregate Alzheimer's disease tissue derived tau fibrils in vitro. Nature communications 13 (1) (2022)
Catharine C Shipps, H Ray Kelly, Peter J Dahl, Sophia M Yi, Dennis Vu, David R Boyer, Calina Glynn, Michael R Sawaya, David S Eisenberg, Victor S Batista, Nikhil S Malvankar
Intrinsic electronic conductivity of individual atomically resolved amyloid crystals reveals micrometer-long hole hopping via tyrosines. Proceedings of the National Academy of Sciences of the United States of America 118 (2) (2021)
Einav Tayeb-Fligelman, Xinyi Cheng, Christen Tai, Jeannette T Bowler, Sarah Griner, Michael R Sawaya, Paul M Seidler, Yi Xiao Jiang, Jiahui Lu, Gregory M Rosenberg, Lukasz Salwinski, Romany Abskharon, Chih-Te Zee, Ke Hou, Yan Li, David R Boyer, Kevin A Murray, Genesis Falcon, Daniel H Anderson, Duilio Cascio, Lorena Saelices, Robert Damoiseaux, Feng Guo, David S Eisenberg
Inhibition of amyloid formation of the Nucleoprotein of SARS-CoV-2. bioRxiv : the preprint server for biology (2021)
Qin Cao, David R Boyer, Michael R Sawaya, Romany Abskharon, Lorena Saelices, Binh An Nguyen, Jiahui Lu, Kevin A Murray, Fouad Kandeel, David S Eisenberg
Cryo-EM structures of hIAPP fibrils seeded by patient-extracted fibrils reveal new polymorphs and conserved fibril cores. Nature structural & molecular biology 28 (9) (2021)
Romany Abskharon, Paul Matthew Seidler, Michael R Sawaya, Duilio Cascio, Tianxiao P Yang, Stephan Philipp, Christopher Kazu Williams, Kathy L Newell, Bernardino F Ghetti, Michael A DeTure, Dennis W Dickson, Harry V Vinters, Philip L Felgner, Rie Nakajima, Charles G Glabe, David S Eisenberg
Crystal structure of a conformational antibody that binds tau oligomers and inhibits pathological seeding by extracts from donors with Alzheimer's disease. The Journal of biological chemistry 295 (31) (2020)
Smriti Sangwan, Shruti Sahay, Kevin A Murray, Sophie Morgan, Elizabeth L Guenther, Lin Jiang, Christopher K Williams, Harry V Vinters, Michel Goedert, David S Eisenberg
Inhibition of synucleinopathic seeding by rationally designed inhibitors. eLife 9 (2020)
Jiahui Lu, Qin Cao, Michael P Hughes, Michael R Sawaya, David R Boyer, Duilio Cascio, David S Eisenberg
CryoEM structure of the low-complexity domain of hnRNPA2 and its conversion to pathogenic amyloid. Nature communications 11 (1) (2020)
Calina Glynn, Michael R Sawaya, Peng Ge, Marcus Gallagher-Jones, Connor W Short, Ronquiajah Bowman, Marcin Apostol, Z Hong Zhou, David S Eisenberg, José A Rodriguez
Cryo-EM structure of a human prion fibril with a hydrophobic, protease-resistant core. Nature structural & molecular biology 27 (5) (2020)
Qin Cao, David R Boyer, Michael R Sawaya, Peng Ge, David S Eisenberg
Cryo-EM structure and inhibitor design of human IAPP (amylin) fibrils. Nature structural & molecular biology 27 (7) (2020)
Sarah L Griner, Paul Seidler, Jeannette T Bowler, Kevin A Murray, Tianxiao Peter Yang, Shruti Sahay, Michael R Sawaya, Duilio Cascio, Jose A Rodriguez, Stephan Philipp, Justyna Sosna, Charles G Glabe, Tamir Gonen, David S Eisenberg
Structure-based inhibitors of amyloid beta core suggest a common interface with tau. eLife 8 (2019)
David R Boyer, Binsen Li, Chuanqi Sun, Weijia Fan, Michael R Sawaya, Lin Jiang, David S Eisenberg
Structures of fibrils formed by α-synuclein hereditary disease mutant H50Q reveal new polymorphs. Nature structural & molecular biology 26 (11) (2019)
Vasantha Basavalingappa, Santu Bera, Bin Xue, Ido Azuri, Yiming Tang, Kai Tao, Linda J W Shimon, Michael R Sawaya, Sofiya Kolusheva, David S Eisenberg, Leeor Kronik, Yi Cao, Guanghong Wei, Ehud Gazit
Mechanically rigid supramolecular assemblies formed from an Fmoc-guanine conjugated peptide nucleic acid. Nature communications 10 (1) (2019)
Rebeccah A Warmack, David R Boyer, Chih-Te Zee, Logan S Richards, Michael R Sawaya, Duilio Cascio, Tamir Gonen, David S Eisenberg, Steven G Clarke
Structure of amyloid-β (20-34) with Alzheimer's-associated isomerization at Asp23 reveals a distinct protofilament interface. Nature communications 10 (1) (2019)
Paul Matthew Seidler, David R Boyer, Kevin A Murray, Tianxiao P Yang, Megan Bentzel, Michael R Sawaya, Gregory Rosenberg, Duilio Cascio, Christopher Kazu Williams, Kathy L Newell, Bernardino Ghetti, Michael A DeTure, Dennis W Dickson, Harry V Vinters, David S Eisenberg
Structure-based inhibitors halt prion-like seeding by Alzheimer's disease-and tauopathy-derived brain tissue samples. The Journal of biological chemistry 294 (44) (2019)
Qin Cao, David R Boyer, Michael R Sawaya, Peng Ge, David S Eisenberg
Cryo-EM structures of four polymorphic TDP-43 amyloid cores. Nature structural & molecular biology 26 (7) (2019)
Elizabeth L Guenther, Qin Cao, Hamilton Trinh, Jiahui Lu, Michael R Sawaya, Duilio Cascio, David R Boyer, José A Rodriguez, Michael P Hughes, David S Eisenberg
Atomic structures of TDP-43 LCD segments and insights into reversible or pathogenic aggregation. Nature structural & molecular biology 25 (6) (2018)
Boris Brumshtein, Shannon R Esswein, Michael R Sawaya, Gregory Rosenberg, Alan T Ly, Meytal Landau, David S Eisenberg
Identification of two principal amyloid-driving segments in variable domains of Ig light chains in systemic light-chain amyloidosis. The Journal of biological chemistry 293 (51) (2018)
Binsen Li, Peng Ge, Kevin A Murray, Phorum Sheth, Meng Zhang, Gayatri Nair, Michael R Sawaya, Woo Shik Shin, David R Boyer, Shulin Ye, David S Eisenberg, Z Hong Zhou, Lin Jiang
Cryo-EM of full-length α-synuclein reveals fibril polymorphs with a common structural kernel. Nature communications 9 (1) (2018)
Qin Cao, Woo Shik Shin, Henry Chan, Celine K Vuong, Bethany Dubois, Binsen Li, Kevin A Murray, Michael R Sawaya, Juli Feigon, Douglas L Black, David S Eisenberg, Lin Jiang
Inhibiting amyloid-β cytotoxicity through its interaction with the cell surface receptor LilrB2 by structure-based design. Nature chemistry 10 (12) (2018)
Michael P Hughes, Michael R Sawaya, David R Boyer, Lukasz Goldschmidt, José A Rodriguez, Duilio Cascio, Lisa Chong, Tamir Gonen, David S Eisenberg
Atomic structures of low-complexity protein segments reveal kinked β sheets that assemble networks. Science (New York, N.Y.) 359 (6376) (2018)
Elizabeth L Guenther, Peng Ge, Hamilton Trinh, Michael R Sawaya, Duilio Cascio, David R Boyer, Tamir Gonen, Z Hong Zhou, David S Eisenberg
Atomic-level evidence for packing and positional amyloid polymorphism by segment from TDP-43 RRM2. Nature structural & molecular biology 25 (4) (2018)
Marcus Gallagher-Jones, Calina Glynn, David R Boyer, Michael W Martynowycz, Evelyn Hernandez, Jennifer Miao, Chih-Te Zee, Irina V Novikova, Lukasz Goldschmidt, Heather T McFarlane, Gustavo F Helguera, James E Evans, Michael R Sawaya, Duilio Cascio, David S Eisenberg, Tamir Gonen, José A Rodriguez
Sub-ångström cryo-EM structure of a prion protofibril reveals a polar clasp. Nature structural & molecular biology 25 (2) (2018)
Laura McPartland, Danielle M Heller, David S Eisenberg, Ann Hochschild, Michael R Sawaya
Atomic insights into the genesis of cellular filaments by globular proteins. Nature structural & molecular biology 25 (8) (2018)
Paul Matthew Seidler, D R Boyer, J A Rodriguez, M R Sawaya, D Cascio, K Murray, T Gonen, David S Eisenberg
Structure-based inhibitors of tau aggregation. Nature chemistry 10 (2) (2017)