Lorena Saelices

Scopus Author ID ORCID

Publication Activity (10 Years)

Years Active: 2018-2024
Publications (10 Years): 42

Top Venues

Nature chemical biology

bioRxiv : the preprint server for biology

Nature communications

Circulation

The University of Texas Southwestern Medical Center

University of Seville (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

The University of Texas Southwestern Medical Center Jun 08 2020

United States

Assistant Professor :: Center for Alzheimer's and Neurodegenerative Diseases / Biophysics

Education History

University of Seville Sep 01 2006 - Dec 16 2010

Spain

PHD :: Biochemistry

Publications

Rose Pedretti, Lanie Wang, Mazen Hanna, Merrill D Benson, Justin L Grodin, Wai Hong Wilson Tang, Ahmad Masri, Lorena Saelices
Detection of Circulating Transthyretin Amyloid Aggregates in Plasma: A Novel Biomarker for Transthyretin Amyloidosis. Circulation 149 (21) (2024)
Maria Del Carmen Fernandez-Ramirez, Binh An Nguyen, Virender Singh, Shumaila Afrin, Bret Evers, Parker Basset, Lanie Wang, Maja Pekala, Yasmin Ahmed, Preeti Singh, Jacob Canepa, Aleksandra Wosztyl, Yang Li, Lorena Saelices
Multi-organ structural homogeneity of amyloid fibrils in ATTRv-T60A amyloidosis patients, revealed by Cryo-EM. bioRxiv : the preprint server for biology (2024)
Binh An Nguyen, Virender Singh, Shumaila Afrin, Preeti Singh, Maja Pekala, Yasmin Ahmed, Rose Pedretti, Jacob Canepa, Andrew Lemoff, Barbara Kluve-Beckerman, Pawel M Wydorski, Farzeen Chhapra, Lorena Saelices
Cryo-EM confirms a common fibril fold in the heart of four patients with ATTRwt amyloidosis. Communications biology 7 (1) (2024)
Aaron T Balana, Anne-Laure Mahul-Mellier, Binh An Nguyen, Mian Horvath, Afraah Javed, Eldon R Hard, Yllza Jasiqi, Preeti Singh, Shumaila Afrin, Rose Pedretti, Virender Singh, Virginia M-Y Lee, Kelvin C Luk, Lorena Saelices, Hilal A Lashuel, Matthew R Pratt
O-GlcNAc forces an α-synuclein amyloid strain with notably diminished seeding and pathology. Nature chemical biology 20 (5) (2024)
Aaron T Balana, Anne-Laure Mahul-Mellier, Binh An Nguyen, Mian Horvath, Afraah Javed, Eldon R Hard, Yllza Jasiqi, Preeti Singh, Shumaila Afrin, Rose Pedretti, Virender Singh, Virginia M-Y Lee, Kelvin C Luk, Lorena Saelices, Hilal A Lashuel, Matthew R Pratt
O-GlcNAc forces an α-synuclein amyloid strain with notably diminished seeding and pathology. Nature chemical biology (2024)
Rose Pedretti, Lanie Wang, Mazen Hanna, Merrill D Benson, Justin L Grodin, Wai Hong Wilson Tang, Ahmad Masri, Lorena Saelices
Detection of Circulating Transthyretin Amyloid Aggregates in Plasma: A Novel Biomarker for Transthyretin Amyloidosis. Circulation 149 (21) (2024)
Aaron T Balana, Anne-Laure Mahul-Mellier, Binh An Nguyen, Mian Horvath, Afraah Javed, Eldon R Hard, Yllza Jasiqi, Preeti Singh, Shumaila Afrin, Rose Pedretti, Virender Singh, Virginia M-Y Lee, Kelvin C Luk, Lorena Saelices, Hilal A Lashuel, Matthew R Pratt
O-GlcNAc forces an α-synuclein amyloid strain with notably diminished seeding and pathology. Nature chemical biology (2024)
Binh An Nguyen, Shumaila Afrin, Anna Yakubovska, Virender Singh, Jaime Vaquer Alicea, Peter Kunach, Preeti Singh, Maja Pekala, Yasmin Ahmed, Maria Del Carmen Fernandez-Ramirez, Luis O Cabrera Hernandez, Rose Pedretti, Parker Basset, Lanie Wang, Andrew Lemoff, Layla Villalon, Barbara Kluve-Beckerman, Lorena Saelices
ATTRv-V30M Type A amyloid fibrils from heart and nerves exhibit structural homogeneity. bioRxiv : the preprint server for biology (2024)
Binh An Nguyen, Virender Singh, Shumaila Afrin, Preeti Singh, Maja Pekala, Yasmin Ahmed, Rose Pedretti, Jacob Canepa, Andrew Lemoff, Barbara Kluve-Beckerman, Pawel Wydorski, Farzeen Chhapra, Lorena Saelices
Cryo-EM confirms a common fibril fold in the heart of four patients with ATTRwt amyloidosis. bioRxiv : the preprint server for biology (2024)
Binh An Nguyen, Virender Singh, Shumaila Afrin, Preeti Singh, Maja Pekala, Yasmin Ahmed, Rose Pedretti, Jacob Canepa, Andrew Lemoff, Barbara Kluve-Beckerman, Pawel Wydorski, Farzeen Chhapra, Lorena Saelices
Cryo-EM confirms a common fibril fold in the heart of four patients with ATTRwt amyloidosis. bioRxiv : the preprint server for biology (2024)
Binh An Nguyen, Virender Singh, Shumaila Afrin, Anna Yakubovska, Lanie Wang, Yasmin Ahmed, Rose Pedretti, Maria Del Carmen Fernandez-Ramirez, Preeti Singh, Maja Pękała, Luis O Cabrera Hernandez, Siddharth Kumar, Andrew Lemoff, Román González-Prieto, Michael R Sawaya, David S Eisenberg, Merrill Douglas Benson, Lorena Saelices
Structural polymorphism of amyloid fibrils in ATTR amyloidosis revealed by cryo-electron microscopy. Nature communications 15 (1) (2024)
Maria Del Carmen Fernandez-Ramirez, Binh An Nguyen, Virender Singh, Shumaila Afrin, Bret Evers, Parker Basset, Lanie Wang, Maja Pekala, Yasmin Ahmed, Preeti Singh, Jacob Canepa, Aleksandra Wosztyl, Yang Li, Lorena Saelices
Multi-organ structural homogeneity of amyloid fibrils in ATTRv-T60A amyloidosis patients, revealed by Cryo-EM. bioRxiv : the preprint server for biology (2024)
Yasmin Ahmed, Binh An Nguyen, Shumaila Afrin, Virender Singh, Bret M Evers, Preeti Singh, Rose Pedretti, Lanie Wang, Parker Bassett, Maria Del Carmen Fernandez-Ramirez, Maja Pekala, Barbara Kluve-Beckerman, Lorena Saelices
Amyloid fibril polymorphism in the heart of an ATTR amyloidosis patient with polyneuropathy attributed to the V122Δ variant. bioRxiv : the preprint server for biology (2024)
Binh An Nguyen, Shumaila Afrin, Anna Yakubovska, Virender Singh, Jaime Vaquer Alicea, Peter Kunach, Preeti Singh, Maja Pekala, Yasmin Ahmed, Maria Del Carmen Fernandez-Ramirez, Luis O Cabrera Hernandez, Rose Pedretti, Parker Basset, Lanie Wang, Andrew Lemoff, Layla Villalon, Barbara Kluve-Beckerman, Lorena Saelices
ATTRv-V30M Type A amyloid fibrils from heart and nerves exhibit structural homogeneity. bioRxiv : the preprint server for biology (2024)
Aaron T Balana, Anne-Laure Mahul-Mellier, Binh An Nguyen, Mian Horvath, Afraah Javed, Eldon R Hard, Yllza Jasiqi, Preeti Singh, Shumaila Afrin, Rose Pedretti, Virender Singh, Virginia M-Y Lee, Kelvin C Luk, Lorena Saelices, Hilal A Lashuel, Matthew R Pratt
O-GlcNAc forces an α-synuclein amyloid strain with notably diminished seeding and pathology. Nature chemical biology (2024)
Binh An Nguyen, Virender Singh, Shumaila Afrin, Anna Yakubovska, Lanie Wang, Yasmin Ahmed, Rose Pedretti, Maria Del Carmen Fernandez-Ramirez, Preeti Singh, Maja Pękała, Luis O Cabrera Hernandez, Siddharth Kumar, Andrew Lemoff, Román González-Prieto, Michael R Sawaya, David S Eisenberg, Merrill Douglas Benson, Lorena Saelices
Structural polymorphism of amyloid fibrils in ATTR amyloidosis revealed by cryo-electron microscopy. Nature communications 15 (1) (2024)
Binh An Nguyen, Virender Singh, Shumaila Afrin, Anna Yakubovska, Lanie Wang, Yasmin Ahmed, Rose Pedretti, Maria Del Carmen Fernandez-Ramirez, Preeti Singh, Maja Pękała, Luis O Cabrera Hernandez, Siddharth Kumar, Andrew Lemoff, Román González-Prieto, Michael R Sawaya, David S Eisenberg, Merrill Douglas Benson, Lorena Saelices
Structural polymorphism of amyloid fibrils in ATTR amyloidosis revealed by cryo-electron microscopy. Nature communications 15 (1) (2024)
Maria Del Carmen Fernandez-Ramirez, Binh An Nguyen, Preeti Singh, Shumaila Afrin, Bret Evers, Parker Basset, Lanie Wang, Maja Pekala, Yasmin Ahmed, Virender Singh, Jacob Canepa, Aleksandra Wosztyl, Yang Li, Lorena Saelices
Multi-organ structural homogeneity of amyloid fibrils in ATTRv-T60A amyloidosis patients, revealed by Cryo-EM. bioRxiv : the preprint server for biology (2024)
Yasmin Ahmed, Binh An Nguyen, Shumaila Afrin, Virender Singh, Bret M Evers, Preeti Singh, Rose Pedretti, Lanie Wang, Parker Bassett, Maria Del Carmen Fernandez-Ramirez, Maja Pekala, Barbara Kluve-Beckerman, Lorena Saelices
Amyloid fibril polymorphism in the heart of an ATTR amyloidosis patient with polyneuropathy attributed to the V122Δ variant. bioRxiv : the preprint server for biology (2024)
Binh An Nguyen, Virender Singh, Shumaila Afrin, Preeti Singh, Maja Pekala, Yasmin Ahmed, Rose Pedretti, Jacob Canepa, Andrew Lemoff, Barbara Kluve-Beckerman, Pawel M Wydorski, Farzeen Chhapra, Lorena Saelices
Cryo-EM confirms a common fibril fold in the heart of four patients with ATTRwt amyloidosis. Communications biology 7 (1) (2024)
Aaron T Balana, Anne-Laure Mahul-Mellier, Binh An Nguyen, Mian Horvath, Afraah Javed, Eldon R Hard, Yllza Jasiqi, Preeti Singh, Shumaila Afrin, Rose Pedretti, Virender Singh, Virginia M-Y Lee, Kelvin C Luk, Lorena Saelices, Hilal A Lashuel, Matthew R Pratt
O-GlcNAc forces an α-synuclein amyloid strain with notably diminished seeding and pathology. Nature chemical biology (2024)
Aaron T Balana, Anne-Laure Mahul-Mellier, Binh An Nguyen, Mian Horvath, Afraah Javed, Eldon R Hard, Yllza Jasiqi, Preeti Singh, Shumaila Afrin, Rose Pedretti, Virender Singh, Virginia M-Y Lee, Kelvin C Luk, Lorena Saelices, Hilal A Lashuel, Matthew R Pratt
O-GlcNAc forces an α-synuclein amyloid strain with notably diminished seeding and pathology. Nature chemical biology (2024)
Binh An Nguyen, Virender Singh, Shumaila Afrin, Preeti Singh, Maja Pekala, Yasmin Ahmed, Rose Pedretti, Jacob Canepa, Andrew Lemoff, Barbara Kluve-Beckerman, Pawel Wydorski, Farzeen Chhapra, Lorena Saelices
Cryo-EM confirms a common fibril fold in the heart of four patients with ATTRwt amyloidosis. bioRxiv : the preprint server for biology (2024)
Aaron T Balana, Anne-Laure Mahul-Mellier, Binh An Nguyen, Mian Horvath, Afraah Javed, Eldon R Hard, Yllza Jasiqi, Preeti Singh, Shumaila Afrin, Rose Pedretti, Virender Singh, Virginia M-Y Lee, Kelvin C Luk, Lorena Saelices, Hilal A Lashuel, Matthew R Pratt
O-GlcNAc forces an α-synuclein amyloid strain with notably diminished seeding and pathology. Nature chemical biology 20 (5) (2024)
Binh An Nguyen, Virender Singh, Shumaila Afrin, Anna Yakubovska, Lanie Wang, Yasmin Ahmed, Rose Pedretti, Maria Del Carmen Fernandez-Ramirez, Preeti Singh, Maja Pękała, Luis O Cabrera Hernandez, Siddharth Kumar, Andrew Lemoff, Román González-Prieto, Michael R Sawaya, David S Eisenberg, Merrill Douglas Benson, Lorena Saelices
Structural polymorphism of amyloid fibrils in ATTR amyloidosis revealed by cryo-electron microscopy. Nature communications 15 (1) (2024)
Rose Pedretti, Lanie Wang, Mazen Hanna, Merrill D Benson, Justin L Grodin, Wai Hong Wilson Tang, Ahmad Masri, Lorena Saelices
Detection of Circulating Transthyretin Amyloid Aggregates in Plasma: A Novel Biomarker for Transthyretin Amyloidosis. Circulation 149 (21) (2024)
Aaron T Balana, Anne-Laure Mahul-Mellier, Binh An Nguyen, Mian Horvath, Afraah Javed, Eldon R Hard, Yllza Jasiqi, Preeti Singh, Shumaila Afrin, Rose Pedretti, Virender Singh, Virginia M-Y Lee, Kelvin C Luk, Lorena Saelices, Hilal A Lashuel, Matthew R Pratt
O-GlcNAc forces an α-synuclein amyloid strain with notably diminished seeding and pathology. Nature chemical biology 20 (5) (2024)
Aaron T Balana, Anne-Laure Mahul-Mellier, Binh An Nguyen, Mian Horvath, Afraah Javed, Eldon R Hard, Yllza Jasiqi, Preeti Singh, Shumaila Afrin, Rose Pedretti, Virender Singh, Virginia M-Y Lee, Kelvin C Luk, Lorena Saelices, Hilal A Lashuel, Matthew R Pratt
Author Correction: O-GlcNAc forces an α-synuclein amyloid strain with notably diminished seeding and pathology. Nature chemical biology (2024)
Aaron T Balana, Anne-Laure Mahul-Mellier, Binh An Nguyen, Mian Horvath, Afraah Javed, Eldon R Hard, Yllza Jasiqi, Preeti Singh, Shumaila Afrin, Rose Pedretti, Virender Singh, Virginia M-Y Lee, Kelvin C Luk, Lorena Saelices, Hilal A Lashuel, Matthew R Pratt
Author Correction: O-GlcNAc forces an α-synuclein amyloid strain with notably diminished seeding and pathology. Nature chemical biology (2024)
Binh An Nguyen, Virender Singh, Shumaila Afrin, Anna Yakubovska, Lanie Wang, Yasmin Ahmed, Rose Pedretti, Maria Del Carmen Fernandez-Ramirez, Preeti Singh, Maja Pękała, Luis O Cabrera Hernandez, Siddharth Kumar, Andrew Lemoff, Román González-Prieto, Michael R Sawaya, David S Eisenberg, Merrill Douglas Benson, Lorena Saelices
Structural polymorphism of amyloid fibrils in ATTR amyloidosis revealed by cryo-electron microscopy. Nature communications 15 (1) (2024)
Aaron T Balana, Anne-Laure Mahul-Mellier, Binh An Nguyen, Mian Horvath, Afraah Javed, Eldon R Hard, Yllza Jasiqi, Preeti Singh, Shumaila Afrin, Rose Pedretti, Virender Singh, Virginia M-Y Lee, Kelvin C Luk, Lorena Saelices, Hilal A Lashuel, Matthew R Pratt
O-GlcNAc forces an α-synuclein amyloid strain with notably diminished seeding and pathology. Nature chemical biology (2024)
Maria Del Carmen Fernandez-Ramirez, Binh An Nguyen, Preeti Singh, Shumaila Afrin, Bret Evers, Parker Basset, Lanie Wang, Maja Pekala, Yasmin Ahmed, Virender Singh, Jacob Canepa, Aleksandra Wosztyl, Yang Li, Lorena Saelices
Multi-organ structural homogeneity of amyloid fibrils in ATTRv-T60A amyloidosis patients, revealed by Cryo-EM. bioRxiv : the preprint server for biology (2024)
Binh An Nguyen, Shumaila Afrin, Anna Yakubovska, Virender Singh, Jaime Vaquer Alicea, Peter Kunach, Preeti Singh, Maja Pekala, Yasmin Ahmed, Maria Del Carmen Fernandez-Ramirez, Luis O Cabrera Hernandez, Rose Pedretti, Parker Basset, Lanie Wang, Andrew Lemoff, Layla Villalon, Barbara Kluve-Beckerman, Lorena Saelices
ATTRv-V30M Type A amyloid fibrils from heart and nerves exhibit structural homogeneity. bioRxiv : the preprint server for biology (2024)
Aaron T Balana, Anne-Laure Mahul-Mellier, Binh An Nguyen, Mian Horvath, Afraah Javed, Eldon R Hard, Yllza Jasiqi, Preeti Singh, Shumaila Afrin, Rose Pedretti, Virender Singh, Virginia M-Y Lee, Kelvin C Luk, Lorena Saelices, Hilal A Lashuel, Matthew R Pratt
O-GlcNAc forces an α-synuclein amyloid strain with notably diminished seeding and pathology. Nature chemical biology (2024)
Yasmin Ahmed, Binh An Nguyen, Shumaila Afrin, Virender Singh, Bret M Evers, Preeti Singh, Rose Pedretti, Lanie Wang, Parker Bassett, Maria Del Carmen Fernandez-Ramirez, Maja Pekala, Barbara Kluve-Beckerman, Lorena Saelices
Amyloid fibril polymorphism in the heart of an ATTR amyloidosis patient with polyneuropathy attributed to the V122Δ variant. bioRxiv : the preprint server for biology (2024)
Rose Pedretti, Lanie Wang, Mazen Hanna, Merrill D Benson, Justin L Grodin, Wai Hong Wilson Tang, Ahmad Masri, Lorena Saelices
Detection of Circulating Transthyretin Amyloid Aggregates in Plasma: A Novel Biomarker for Transthyretin Amyloidosis. Circulation 149 (21) (2024)
Aaron T Balana, Anne-Laure Mahul-Mellier, Binh An Nguyen, Mian Horvath, Afraah Javed, Eldon R Hard, Yllza Jasiqi, Preeti Singh, Shumaila Afrin, Rose Pedretti, Virender Singh, Virginia M-Y Lee, Kelvin C Luk, Lorena Saelices, Hilal A Lashuel, Matthew R Pratt
O-GlcNAc forces an α-synuclein amyloid strain with notably diminished seeding and pathology. Nature chemical biology 20 (5) (2024)
Einav Tayeb-Fligelman, Jeannette T Bowler, Christen E Tai, Michael R Sawaya, Yi Xiao Jiang, Gustavo Garcia, Sarah L Griner, Xinyi Cheng, Lukasz Salwinski, Liisa Lutter, Paul M Seidler, Jiahui Lu, Gregory M Rosenberg, Ke Hou, Romany Abskharon, Hope Pan, Chih-Te Zee, David R Boyer, Yan Li, Daniel H Anderson, Kevin A Murray, Genesis Falcon, Duilio Cascio, Lorena Saelices, Robert Damoiseaux, Vaithilingaraja Arumugaswami, Feng Guo, David S Eisenberg
Low complexity domains of the nucleocapsid protein of SARS-CoV-2 form amyloid fibrils. Nature communications 14 (1) (2023)
Einav Tayeb-Fligelman, Jeannette T Bowler, Christen E Tai, Michael R Sawaya, Yi Xiao Jiang, Gustavo Garcia, Sarah L Griner, Xinyi Cheng, Lukasz Salwinski, Liisa Lutter, Paul M Seidler, Jiahui Lu, Gregory M Rosenberg, Ke Hou, Romany Abskharon, Hope Pan, Chih-Te Zee, David R Boyer, Yan Li, Daniel H Anderson, Kevin A Murray, Genesis Falcon, Duilio Cascio, Lorena Saelices, Robert Damoiseaux, Vaithilingaraja Arumugaswami, Feng Guo, David S Eisenberg
Low complexity domains of the nucleocapsid protein of SARS-CoV-2 form amyloid fibrils. Nature communications 14 (1) (2023)
Qin Cao, David R Boyer, Michael R Sawaya, Romany Abskharon, Lorena Saelices, Binh An Nguyen, Jiahui Lu, Kevin A Murray, Fouad Kandeel, David S Eisenberg
Cryo-EM structures of hIAPP fibrils seeded by patient-extracted fibrils reveal new polymorphs and conserved fibril cores. Nature structural & molecular biology 28 (9) (2021)
Lorena Saelices, Stuart A Sievers, Michael R Sawaya, David S Eisenberg
Crystal structures of amyloidogenic segments of human transthyretin. Protein science : a publication of the Protein Society 27 (7) (2018)
Lorena Saelices, Kevin Chung, Ji H Lee, Whitaker Cohn, Julian P Whitelegge, Merrill D Benson, David S Eisenberg
Amyloid seeding of transthyretin by ex vivo cardiac fibrils and its inhibition. Proceedings of the National Academy of Sciences of the United States of America 115 (29) (2018)

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Publication Activity (10 Years)

Top Topics

Top Venues

Lorena Saelices