Denise Wootten

Scopus Author ID ORCID

Publication Activity (10 Years)

Years Active: 2020-2024
Publications (10 Years): 28

Top Topics

Molecular Dynamics Simulations

Structural Basis

Binding Protein

Breast Cancer Cells

Top Venues

Nature communications

Science (New York, N.Y.)

Nature chemical biology

This page only lists publications with an associated author ORCID identifier.

Publications

Isabella C Russell, Xin Zhang, Fabian Bumbak, Samantha M McNeill, Tracy M Josephs, Michael G Leeming, George Christopoulos, Hariprasad Venugopal, Maria M Flocco, Patrick M Sexton, Denise Wootten, Matthew J Belousoff
Lipid-Dependent Activation of the Orphan G Protein-Coupled Receptor, GPR3. Biochemistry 63 (5) (2024)
Isabella C Russell, Xin Zhang, Fabian Bumbak, Samantha M McNeill, Tracy M Josephs, Michael G Leeming, George Christopoulos, Hariprasad Venugopal, Maria M Flocco, Patrick M Sexton, Denise Wootten, Matthew J Belousoff
Lipid-Dependent Activation of the Orphan G Protein-Coupled Receptor, GPR3. Biochemistry 63 (5) (2024)
Chaitra Chandrashekar, Feng Lin, Yuji Nishiuchi, Sam F Mohammed, Barbara F White, Yanni Arsenakis, Elita Yuliantie, Peishen Zhao, Sam van Dun, Anna Koijen, Yasuhiro Kajihara, Denise Wootten, Garron T Dodd, Leendert J van den Bos, John D Wade, Mohammed Akhter Hossain
Engineering of a Biologically Active Glycosylated Glucagon-Like Peptide-1 Analogue. Journal of medicinal chemistry (2024)
Jianjun Cao, Matthew J Belousoff, Radostin Danev, Arthur Christopoulos, Denise Wootten, Patrick M Sexton
Cryo-EM Structure of the Human Amylin 1 Receptor in Complex with CGRP and Gs Protein. Biochemistry 63 (9) (2024)
Kaleeckal G Harikumar, Sarah J Piper, Arthur Christopoulos, Denise Wootten, Patrick M Sexton, Laurence J Miller
Impact of secretin receptor homo-dimerization on natural ligand binding. Nature communications 15 (1) (2024)
Jianjun Cao, Matthew J Belousoff, Radostin Danev, Arthur Christopoulos, Denise Wootten, Patrick M Sexton
Cryo-EM Structure of the Human Amylin 1 Receptor in Complex with CGRP and Gs Protein. Biochemistry (2024)
Jianjun Cao, Matthew J Belousoff, Radostin Danev, Arthur Christopoulos, Denise Wootten, Patrick M Sexton
Cryo-EM Structure of the Human Amylin 1 Receptor in Complex with CGRP and Gs Protein. Biochemistry 63 (9) (2024)
Jianjun Cao, Matthew J Belousoff, Radostin Danev, Arthur Christopoulos, Denise Wootten, Patrick M Sexton
Cryo-EM Structure of the Human Amylin 1 Receptor in Complex with CGRP and Gs Protein. Biochemistry 63 (9) (2024)
Isabella C Russell, Xin Zhang, Fabian Bumbak, Samantha M McNeill, Tracy M Josephs, Michael G Leeming, George Christopoulos, Hariprasad Venugopal, Maria M Flocco, Patrick M Sexton, Denise Wootten, Matthew J Belousoff
Lipid-Dependent Activation of the Orphan G Protein-Coupled Receptor, GPR3. Biochemistry (2024)
Jianjun Cao, Matthew J Belousoff, Radostin Danev, Arthur Christopoulos, Denise Wootten, Patrick M Sexton
Cryo-EM Structure of the Human Amylin 1 Receptor in Complex with CGRP and Gs Protein. Biochemistry 63 (9) (2024)
Isabella C Russell, Xin Zhang, Fabian Bumbak, Samantha M McNeill, Tracy M Josephs, Michael G Leeming, George Christopoulos, Hariprasad Venugopal, Maria M Flocco, Patrick M Sexton, Denise Wootten, Matthew J Belousoff
Lipid-Dependent Activation of the Orphan G Protein-Coupled Receptor, GPR3. Biochemistry 63 (5) (2024)
Kaleeckal G Harikumar, Sarah J Piper, Arthur Christopoulos, Denise Wootten, Patrick M Sexton, Laurence J Miller
Impact of secretin receptor homo-dimerization on natural ligand binding. Nature communications 15 (1) (2024)
Kaleeckal G Harikumar, Sarah J Piper, Arthur Christopoulos, Denise Wootten, Patrick M Sexton, Laurence J Miller
Impact of secretin receptor homo-dimerization on natural ligand binding. Nature communications 15 (1) (2024)
Chaitra Chandrashekar, Feng Lin, Yuji Nishiuchi, Sam F Mohammed, Barbara F White, Yanni Arsenakis, Elita Yuliantie, Peishen Zhao, Sam van Dun, Anna Koijen, Yasuhiro Kajihara, Denise Wootten, Garron T Dodd, Leendert J van den Bos, John D Wade, Mohammed Akhter Hossain
Engineering of a Biologically Active Glycosylated Glucagon-Like Peptide-1 Analogue. Journal of medicinal chemistry 67 (9) (2024)
Kaleeckal G Harikumar, Sarah J Piper, Arthur Christopoulos, Denise Wootten, Patrick M Sexton, Laurence J Miller
Impact of secretin receptor homo-dimerization on natural ligand binding. Nature communications 15 (1) (2024)
Isabella C Russell, Xin Zhang, Fabian Bumbak, Samantha M McNeill, Tracy M Josephs, Michael G Leeming, George Christopoulos, Hariprasad Venugopal, Maria M Flocco, Patrick M Sexton, Denise Wootten, Matthew J Belousoff
Lipid-Dependent Activation of the Orphan G Protein-Coupled Receptor, GPR3. Biochemistry 63 (5) (2024)
Wessel A C Burger, Vi Pham, Ziva Vuckovic, Alexander S Powers, Jesse I Mobbs, Yianni Laloudakis, Alisa Glukhova, Denise Wootten, Andrew B Tobin, Patrick M Sexton, Steven M Paul, Christian C Felder, Radostin Danev, Ron O Dror, Arthur Christopoulos, Celine Valant, David M Thal
Xanomeline displays concomitant orthosteric and allosteric binding modes at the M 4 mAChR. Nature communications 14 (1) (2023)
Chaitra Chandrashekar, Yuji Nishiuchi, Barbara Fam White, Yanni Arsenakis, Feng Lin, Samantha M McNeill, Peishen Zhao, Sam van Dun, Anna Koijen, Yasuhiro Kajihara, Denise Wootten, Leendert J van den Bos, John D Wade, Mohammed Akhter Hossain
Glycosylation Improves the Proteolytic Stability of Exenatide. Bioconjugate chemistry (2023)
Jianjun Cao, Matthew J Belousoff, Elliot Gerrard, Radostin Danev, Madeleine M Fletcher, Emma Dal Maso, Herman Schreuder, Katrin Lorenz, Andreas Evers, Garima Tiwari, Melissa Besenius, Ziyu Li, Rachel M Johnson, Denise Wootten, Patrick M Sexton
Structural insight into selectivity of amylin and calcitonin receptor agonists. Nature chemical biology (2023)
Giuseppe Deganutti, Yi-Lynn Liang, Xin Zhang, Maryam Khoshouei, Lachlan Clydesdale, Matthew J Belousoff, Hari Venugopal, Tin T Truong, Alisa Glukhova, Andrew N Keller, Karen J Gregory, Katie Leach, Arthur Christopoulos, Radostin Danev, Christopher A Reynolds, Peishen Zhao, Patrick M Sexton, Denise Wootten
Dynamics of GLP-1R peptide agonist engagement are correlated with kinetics of G protein activation. Nature communications 13 (1) (2022)
Sarah J Piper, Rachel M Johnson, Denise Wootten, Patrick M Sexton
Membranes under the Magnetic Lens: A Dive into the Diverse World of Membrane Protein Structures Using Cryo-EM. Chemical reviews 122 (17) (2022)
Sarah J Piper, Giuseppe Deganutti, Jessica Lu, Peishen Zhao, Yi-Lynn Liang, Yao Lu, Madeleine M Fletcher, Mohammed Akhter Hossain, Arthur Christopoulos, Christopher A Reynolds, Radostin Danev, Patrick M Sexton, Denise Wootten
Understanding VPAC receptor family peptide binding and selectivity. Nature communications 13 (1) (2022)
Jianjun Cao, Matthew J Belousoff, Yi-Lynn Liang, Rachel M Johnson, Tracy M Josephs, Madeleine M Fletcher, Arthur Christopoulos, Debbie L Hay, Radostin Danev, Denise Wootten, Patrick M Sexton
A structural basis for amylin receptor phenotype. Science (New York, N.Y.) 375 (6587) (2022)
Brian P Cary, Xin Zhang, Jianjun Cao, Rachel M Johnson, Sarah J Piper, Elliot J Gerrard, Denise Wootten, Patrick M Sexton
New insights into the structure and function of class B1 GPCRs. Endocrine reviews (2022)
Brian P Cary, Giuseppe Deganutti, Peishen Zhao, Tin T Truong, Sarah J Piper, Xinyu Liu, Matthew J Belousoff, Radostin Danev, Patrick M Sexton, Denise Wootten, Samuel H Gellman
Structural and functional diversity among agonist-bound states of the GLP-1 receptor. Nature chemical biology 18 (3) (2021)
Mengjie Liu, Peishen Zhao, Md Hemayet Uddin, Wenyi Li, Feng Lin, Chaitra Chandrashekar, Yuji Nishiuchi, Yasuhiro Kajihara, Briony E Forbes, Denise Wootten, John D Wade, Mohammed Akhter Hossain
Chemical Synthesis and Characterization of a Nonfibrillating Glycoglucagon. Bioconjugate chemistry 32 (10) (2021)
Tracy M Josephs, Matthew J Belousoff, Yi-Lynn Liang, Sarah J Piper, Jianjun Cao, Daniel J Garama, Katie Leach, Karen J Gregory, Arthur Christopoulos, Debbie L Hay, Radostin Danev, Denise Wootten, Patrick M Sexton
Structure and dynamics of the CGRP receptor in apo and peptide-bound forms. Science (New York, N.Y.) 372 (6538) (2021)
Anna Qiao, Shuo Han, Xinmei Li, Zhixin Li, Peishen Zhao, Antao Dai, Rulue Chang, Linhua Tai, Qiuxiang Tan, Xiaojing Chu, Limin Ma, Thor Seneca Thorsen, Steffen Reedtz-Runge, Dehua Yang, Ming-Wei Wang, Patrick M Sexton, Denise Wootten, Fei Sun, Qiang Zhao, Beili Wu
Structural basis of Gs and Gi recognition by the human glucagon receptor. Science (New York, N.Y.) 367 (6484) (2020)