Ron O Dror

Publication Activity (10 Years)

Years Active: 2016-2024
Publications (10 Years): 62

Top Topics

Acute Myeloid Leukemia

Molecular Dynamics Simulations

Top Venues

Nature structural & molecular biology

Nature communications

Nature chemical biology

This page only lists publications with an associated author ORCID identifier.

Publications

Rohini S Ople, Nokomis Ramos-Gonzalez, Qiongyu Li, Briana L Sobecks, Deniz Aydin, Alexander S Powers, Abdelfattah Faouzi, Benjamin J Polacco, Sarah M Bernhard, Kevin Appourchaux, Sashrik Sribhashyam, Shainnel O Eans, Bowen A Tsai, Ron O Dror, Balazs R Varga, Haoqing Wang, Ruth Hüttenhain, Jay P McLaughlin, Susruta Majumdar
Signaling Modulation Mediated by Ligand Water Interactions with the Sodium Site at μOR. ACS central science 10 (8) (2024)
Nicholas Hoppe, Simone Harrison, Sun-Hee Hwang, Ziwei Chen, Masha Karelina, Ishan Deshpande, Carl-Mikael Suomivuori, Vivek R Palicharla, Samuel P Berry, Philipp Tschaikner, Dominik Regele, Douglas F Covey, Eduard Stefan, Debora S Marks, Jeremy F Reiter, Ron O Dror, Alex S Evers, Saikat Mukhopadhyay, Aashish Manglik
GPR161 structure uncovers the redundant role of sterol-regulated ciliary cAMP signaling in the Hedgehog pathway. Nature structural & molecular biology (2024)
Nicholas Hoppe, Simone Harrison, Sun-Hee Hwang, Ziwei Chen, Masha Karelina, Ishan Deshpande, Carl-Mikael Suomivuori, Vivek R Palicharla, Samuel P Berry, Philipp Tschaikner, Dominik Regele, Douglas F Covey, Eduard Stefan, Debora S Marks, Jeremy F Reiter, Ron O Dror, Alex S Evers, Saikat Mukhopadhyay, Aashish Manglik
GPR161 structure uncovers the redundant role of sterol-regulated ciliary cAMP signaling in the Hedgehog pathway. Nature structural & molecular biology 31 (4) (2024)
Nicholas Hoppe, Simone Harrison, Sun-Hee Hwang, Ziwei Chen, Masha Karelina, Ishan Deshpande, Carl-Mikael Suomivuori, Vivek R Palicharla, Samuel P Berry, Philipp Tschaikner, Dominik Regele, Douglas F Covey, Eduard Stefan, Debora S Marks, Jeremy F Reiter, Ron O Dror, Alex S Evers, Saikat Mukhopadhyay, Aashish Manglik
GPR161 structure uncovers the redundant role of sterol-regulated ciliary cAMP signaling in the Hedgehog pathway. Nature structural & molecular biology 31 (4) (2024)
Mengyuan Xu, Torben Neelands, Alexander S Powers, Yan Liu, Steven D Miller, Grigore D Pintilie, J Du Bois, Ron O Dror, Wah Chiu, Merritt Maduke
CryoEM structures of the human CLC-2 voltage-gated chloride channel reveal a ball-and-chain gating mechanism. eLife 12 (2024)
Mengyuan Xu, Torben Neelands, Alexander S Powers, Yan Liu, Steven D Miller, Grigore D Pintilie, J Du Bois, Ron O Dror, Wah Chiu, Merritt Maduke
CryoEM structures of the human CLC-2 voltage-gated chloride channel reveal a ball-and-chain gating mechanism. eLife 12 (2024)
Mengyuan Xu, Torben Neelands, Alexander S Powers, Yan Liu, Steven D Miller, Grigore D Pintilie, J Du Bois, Ron O Dror, Wah Chiu, Merritt Maduke
CryoEM structures of the human CLC-2 voltage-gated chloride channel reveal a ball-and-chain gating mechanism. eLife 12 (2024)
Nicholas Hoppe, Simone Harrison, Sun-Hee Hwang, Ziwei Chen, Masha Karelina, Ishan Deshpande, Carl-Mikael Suomivuori, Vivek R Palicharla, Samuel P Berry, Philipp Tschaikner, Dominik Regele, Douglas F Covey, Eduard Stefan, Debora S Marks, Jeremy F Reiter, Ron O Dror, Alex S Evers, Saikat Mukhopadhyay, Aashish Manglik
GPR161 structure uncovers the redundant role of sterol-regulated ciliary cAMP signaling in the Hedgehog pathway. Nature structural & molecular biology 31 (4) (2024)
Rohini S Ople, Nokomis Ramos-Gonzalez, Qiongyu Li, Briana L Sobecks, Deniz Aydin, Alexander S Powers, Abdelfattah Faouzi, Benjamin J Polacco, Sarah M Bernhard, Kevin Appourchaux, Sashrik Sribhashyam, Shainnel O Eans, Bowen A Tsai, Ron O Dror, Balazs R Varga, Haoqing Wang, Ruth Hüttenhain, Jay P McLaughlin, Susruta Majumdar
Signaling Modulation Mediated by Ligand Water Interactions with the Sodium Site at μOR. ACS central science 10 (8) (2024)
Nicholas Hoppe, Simone Harrison, Sun-Hee Hwang, Ziwei Chen, Masha Karelina, Ishan Deshpande, Carl-Mikael Suomivuori, Vivek R Palicharla, Samuel P Berry, Philipp Tschaikner, Dominik Regele, Douglas F Covey, Eduard Stefan, Debora S Marks, Jeremy F Reiter, Ron O Dror, Alex S Evers, Saikat Mukhopadhyay, Aashish Manglik
GPR161 structure uncovers the redundant role of sterol-regulated ciliary cAMP signaling in the Hedgehog pathway. Nature structural & molecular biology (2024)
Nicholas Hoppe, Simone Harrison, Sun-Hee Hwang, Ziwei Chen, Masha Karelina, Ishan Deshpande, Carl-Mikael Suomivuori, Vivek R Palicharla, Samuel P Berry, Philipp Tschaikner, Dominik Regele, Douglas F Covey, Eduard Stefan, Debora S Marks, Jeremy F Reiter, Ron O Dror, Alex S Evers, Saikat Mukhopadhyay, Aashish Manglik
GPR161 structure uncovers the redundant role of sterol-regulated ciliary cAMP signaling in the Hedgehog pathway. Nature structural & molecular biology 31 (4) (2024)
Nicholas Hoppe, Simone Harrison, Sun-Hee Hwang, Ziwei Chen, Masha Karelina, Ishan Deshpande, Carl-Mikael Suomivuori, Vivek R Palicharla, Samuel P Berry, Philipp Tschaikner, Dominik Regele, Douglas F Covey, Eduard Stefan, Debora S Marks, Jeremy F Reiter, Ron O Dror, Alex S Evers, Saikat Mukhopadhyay, Aashish Manglik
GPR161 structure uncovers the redundant role of sterol-regulated ciliary cAMP signaling in the Hedgehog pathway. Nature structural & molecular biology (2024)
Mengyuan Xu, Torben Neelands, Alexander S Powers, Yan Liu, Steven D Miller, Grigore D Pintilie, J Du Bois, Ron O Dror, Wah Chiu, Merritt Maduke
CryoEM structures of the human CLC-2 voltage-gated chloride channel reveal a ball-and-chain gating mechanism. eLife 12 (2024)
Mengyuan Xu, Torben Neelands, Alexander S Powers, Yan Liu, Steven D Miller, Grigore D Pintilie, J Du Bois, Ron O Dror, Wah Chiu, Merritt Maduke
CryoEM structures of the human CLC-2 voltage-gated chloride channel reveal a ball-and-chain gating mechanism. eLife 12 (2024)
Mengyuan Xu, Torben Neelands, Alexander S Powers, Yan Liu, Steven D Miller, Grigore D Pintilie, J Du Bois, Ron O Dror, Wah Chiu, Merritt Maduke
CryoEM structures of the human CLC-2 voltage-gated chloride channel reveal a ball-and-chain gating mechanism. eLife 12 (2024)
Nicholas Hoppe, Simone Harrison, Sun-Hee Hwang, Ziwei Chen, Masha Karelina, Ishan Deshpande, Carl-Mikael Suomivuori, Vivek R Palicharla, Samuel P Berry, Philipp Tschaikner, Dominik Regele, Douglas F Covey, Eduard Stefan, Debora S Marks, Jeremy F Reiter, Ron O Dror, Alex S Evers, Saikat Mukhopadhyay, Aashish Manglik
GPR161 structure uncovers the redundant role of sterol-regulated ciliary cAMP signaling in the Hedgehog pathway. Nature structural & molecular biology (2024)
Nicholas Hoppe, Simone Harrison, Sun-Hee Hwang, Ziwei Chen, Masha Karelina, Ishan Deshpande, Carl-Mikael Suomivuori, Vivek R Palicharla, Samuel P Berry, Philipp Tschaikner, Dominik Regele, Douglas F Covey, Eduard Stefan, Debora S Marks, Jeremy F Reiter, Ron O Dror, Alex S Evers, Saikat Mukhopadhyay, Aashish Manglik
GPR161 structure uncovers the redundant role of sterol-regulated ciliary cAMP signaling in the Hedgehog pathway. Nature structural & molecular biology 31 (4) (2024)
Nicholas Hoppe, Simone Harrison, Sun-Hee Hwang, Ziwei Chen, Masha Karelina, Ishan Deshpande, Carl-Mikael Suomivuori, Vivek R Palicharla, Samuel P Berry, Philipp Tschaikner, Dominik Regele, Douglas F Covey, Eduard Stefan, Debora S Marks, Jeremy F Reiter, Ron O Dror, Alex S Evers, Saikat Mukhopadhyay, Aashish Manglik
GPR161 structure uncovers the redundant role of sterol-regulated ciliary cAMP signaling in the Hedgehog pathway. Nature structural & molecular biology (2024)
Nicholas Hoppe, Simone Harrison, Sun-Hee Hwang, Ziwei Chen, Masha Karelina, Ishan Deshpande, Carl-Mikael Suomivuori, Vivek R Palicharla, Samuel P Berry, Philipp Tschaikner, Dominik Regele, Douglas F Covey, Eduard Stefan, Debora S Marks, Jeremy F Reiter, Ron O Dror, Alex S Evers, Saikat Mukhopadhyay, Aashish Manglik
GPR161 structure uncovers the redundant role of sterol-regulated ciliary cAMP signaling in the Hedgehog pathway. Nature structural & molecular biology 31 (4) (2024)
Xinyu Xu, Jeremy Shonberg, Jonas Kaindl, Mary J Clark, Anne Stößel, Luis Maul, Daniel Mayer, Harald Hübner, Kunio Hirata, A J Venkatakrishnan, Ron O Dror, Brian K Kobilka, Roger K Sunahara, Xiangyu Liu, Peter Gmeiner
Constrained catecholamines gain β 2 AR selectivity through allosteric effects on pocket dynamics. Nature communications 14 (1) (2023)
Amal El Daibani, Joseph M Paggi, Kuglae Kim, Yianni D Laloudakis, Petr Popov, Sarah M Bernhard, Brian E Krumm, Reid H J Olsen, Jeffrey Diberto, F Ivy Carroll, Vsevolod Katritch, Bernhard Wünsch, Ron O Dror, Tao Che
Molecular mechanism of biased signaling at the kappa opioid receptor. Nature communications 14 (1) (2023)
Xinyu Xu, Jeremy Shonberg, Jonas Kaindl, Mary J Clark, Anne Stößel, Luis Maul, Daniel Mayer, Harald Hübner, Kunio Hirata, A J Venkatakrishnan, Ron O Dror, Brian K Kobilka, Roger K Sunahara, Xiangyu Liu, Peter Gmeiner
Author Correction: Constrained catecholamines gain β 2 AR selectivity through allosteric effects on pocket dynamics. Nature communications 14 (1) (2023)
Alexander S Powers, Helen H Yu, Patricia Suriana, Rohan V Koodli, Tianyu Lu, Joseph M Paggi, Ron O Dror
Geometric Deep Learning for Structure-Based Ligand Design. ACS central science 9 (12) (2023)
Amal El Daibani, Joseph M Paggi, Kuglae Kim, Yianni D Laloudakis, Petr Popov, Sarah M Bernhard, Brian E Krumm, Reid H J Olsen, Jeffrey Diberto, F Ivy Carroll, Vsevolod Katritch, Bernhard Wünsch, Ron O Dror, Tao Che
Molecular mechanism of biased signaling at the kappa opioid receptor. Nature communications 14 (1) (2023)
Kaavya Krishna Kumar, Michael J Robertson, Elina Thadhani, Haoqing Wang, Carl-Mikael Suomivuori, Alexander S Powers, Lipin Ji, Spyros P Nikas, Ron O Dror, Asuka Inoue, Alexandros Makriyannis, Georgios Skiniotis, Brian K Kobilka
Structural basis for activation of CB1 by an endocannabinoid analog. Nature communications 14 (1) (2023)
Wessel A C Burger, Vi Pham, Ziva Vuckovic, Alexander S Powers, Jesse I Mobbs, Yianni Laloudakis, Alisa Glukhova, Denise Wootten, Andrew B Tobin, Patrick M Sexton, Steven M Paul, Christian C Felder, Radostin Danev, Ron O Dror, Arthur Christopoulos, Celine Valant, David M Thal
Xanomeline displays concomitant orthosteric and allosteric binding modes at the M 4 mAChR. Nature communications 14 (1) (2023)
Alexander S Powers, Helen H Yu, Patricia Suriana, Rohan V Koodli, Tianyu Lu, Joseph M Paggi, Ron O Dror
Geometric Deep Learning for Structure-Based Ligand Design. ACS central science 9 (12) (2023)
Stephan Eismann, Patricia Suriana, Bowen Jing, Raphael J L Townshend, Ron O Dror
Protein model quality assessment using rotation-equivariant transformations on point clouds. Proteins (2023)
S Wenceslao Evans, Dong-Qing Shi, Mariya Chavarha, Mark H Plitt, Jiannis Taxidis, Blake Madruga, Jiang Lan Fan, Fuu-Jiun Hwang, Siri Camee van Keulen, Carl-Mikael Suomivuori, Michelle M Pang, Sharon Su, Sungmoo Lee, Yukun A Hao, Guofeng Zhang, Dongyun Jiang, Lagnajeet Pradhan, Richard H Roth, Yu Liu, Conor C Dorian, Austin L Reese, Adrian Negrean, Attila Losonczy, Christopher D Makinson, Sui Wang, Thomas R Clandinin, Ron O Dror, Jun B Ding, Na Ji, Peyman Golshani, Lisa M Giocomo, Guo-Qiang Bi, Michael Z Lin
A positively tuned voltage indicator for extended electrical recordings in the brain. Nature methods 20 (7) (2023)
Masha Karelina, Joseph J Noh, Ron O Dror
How accurately can one predict drug binding modes using AlphaFold models? eLife 12 (2023)
Alexander S Powers, Helen H Yu, Patricia Suriana, Rohan V Koodli, Tianyu Lu, Joseph M Paggi, Ron O Dror
Geometric Deep Learning for Structure-Based Ligand Design. ACS central science 9 (12) (2023)
Amal El Daibani, Joseph M Paggi, Kuglae Kim, Yianni D Laloudakis, Petr Popov, Sarah M Bernhard, Brian E Krumm, Reid H J Olsen, Jeffrey Diberto, F Ivy Carroll, Vsevolod Katritch, Bernhard Wünsch, Ron O Dror, Tao Che
Molecular mechanism of biased signaling at the kappa opioid receptor. Nature communications 14 (1) (2023)
Alexander S Powers, Vi Pham, Wessel A C Burger, Geoff Thompson, Yianni Laloudakis, Nicholas W Barnes, Patrick M Sexton, Steven M Paul, Arthur Christopoulos, David M Thal, Christian C Felder, Celine Valant, Ron O Dror
Structural basis of efficacy-driven ligand selectivity at GPCRs. Nature chemical biology (2023)
Nicholas Hoppe, Simone Harrison, Sun-Hee Hwang, Zi-Wei Chen, Masha Karelina, Ishan Deshpande, Carl-Mikael Suomivuori, Vivek R Palicharla, Samuel P Berry, Philipp Tschaikner, Dominik Regele, Douglas F Covey, Eduard Stefan, Debora S Marks, Jeremy F Reiter, Ron O Dror, Alex S Evers, Saikat Mukhopadhyay, Aashish Manglik
GPR161 structure uncovers the redundant role of sterol-regulated ciliary cAMP signaling in the Hedgehog pathway. bioRxiv : the preprint server for biology (2023)
Kaavya Krishna Kumar, Michael J Robertson, Elina Thadhani, Haoqing Wang, Carl-Mikael Suomivuori, Alexander S Powers, Lipin Ji, Spyros P Nikas, Ron O Dror, Asuka Inoue, Alexandros Makriyannis, Georgios Skiniotis, Brian K Kobilka
Structural basis for activation of CB1 by an endocannabinoid analog. Nature communications 14 (1) (2023)
Alexander S Powers, Vi Pham, Wessel A C Burger, Geoff Thompson, Yianni Laloudakis, Nicholas W Barnes, Patrick M Sexton, Steven M Paul, Arthur Christopoulos, David M Thal, Christian C Felder, Celine Valant, Ron O Dror
Author Correction: Structural basis of efficacy-driven ligand selectivity at GPCRs. Nature chemical biology (2023)
Masha Karelina, Joseph J Noh, Ron O Dror
How accurately can one predict drug binding modes using AlphaFold models? eLife 12 (2023)
Alexander S Powers, Vi Pham, Wessel A C Burger, Geoff Thompson, Yianni Laloudakis, Nicholas W Barnes, Patrick M Sexton, Steven M Paul, Arthur Christopoulos, David M Thal, Christian C Felder, Celine Valant, Ron O Dror
Author Correction: Structural basis of efficacy-driven ligand selectivity at GPCRs. Nature chemical biology (2023)
Alexander S Powers, Vi Pham, Wessel A C Burger, Geoff Thompson, Yianni Laloudakis, Nicholas W Barnes, Patrick M Sexton, Steven M Paul, Arthur Christopoulos, David M Thal, Christian C Felder, Celine Valant, Ron O Dror
Structural basis of efficacy-driven ligand selectivity at GPCRs. Nature chemical biology (2023)
Kaavya Krishna Kumar, Michael J Robertson, Elina Thadhani, Haoqing Wang, Carl-Mikael Suomivuori, Alexander S Powers, Lipin Ji, Spyros P Nikas, Ron O Dror, Asuka Inoue, Alexandros Makriyannis, Georgios Skiniotis, Brian K Kobilka
Structural basis for activation of CB1 by an endocannabinoid analog. Nature communications 14 (1) (2023)
Masha Karelina, Joseph J Noh, Ron O Dror
How accurately can one predict drug binding modes using AlphaFold models? eLife 12 (2023)
Masha Karelina, Joseph J Noh, Ron O Dror
How accurately can one predict drug binding modes using AlphaFold models? eLife 12 (2023)
Alexander S Powers, Vi Pham, Wessel A C Burger, Geoff Thompson, Yianni Laloudakis, Patrick M Sexton, Steven M Paul, Arthur Christopoulos, David M Thal, Christian C Felder, Celine Valant, Ron O Dror
Structural basis of efficacy-driven ligand selectivity at GPCRs. Nature chemical biology (2023)
Qianhui Qu, Weijiao Huang, Deniz Aydin, Joseph M Paggi, Alpay B Seven, Haoqing Wang, Soumen Chakraborty, Tao Che, Jeffrey F DiBerto, Michael J Robertson, Asuka Inoue, Carl-Mikael Suomivuori, Bryan L Roth, Susruta Majumdar, Ron O Dror, Brian K Kobilka, Georgios Skiniotis
Insights into distinct signaling profiles of the µOR activated by diverse agonists. Nature chemical biology (2022)
Naotaka Tsutsumi, Shoji Maeda, Qianhui Qu, Martin Vögele, Kevin M Jude, Carl-Mikael Suomivuori, Ouliana Panova, Deepa Waghray, Hideaki E Kato, Andrew Velasco, Ron O Dror, Georgios Skiniotis, Brian K Kobilka, K Christopher Garcia
Atypical structural snapshots of human cytomegalovirus GPCR interactions with host G proteins. Science advances 8 (3) (2022)
Bryan Faust, Christian B Billesbølle, Carl-Mikael Suomivuori, Isha Singh, Kaihua Zhang, Nicholas Hoppe, Antonio F M Pinto, Jolene K Diedrich, Yagmur Muftuoglu, Mariusz W Szkudlinski, Alan Saghatelian, Ron O Dror, Yifan Cheng, Aashish Manglik
Autoantibody mimicry of hormone action at the thyrotropin receptor. Nature 609 (7928) (2022)
Kaiming Zhang, Naoki Horikoshi, Shanshan Li, Alexander S Powers, Mikhail A Hameedi, Grigore D Pintilie, Hee-Don Chae, Yousuf A Khan, Carl-Mikael Suomivuori, Ron O Dror, Kathleen M Sakamoto, Wah Chiu, Soichi Wakatsuki
Cryo-EM, Protein Engineering, and Simulation Enable the Development of Peptide Therapeutics against Acute Myeloid Leukemia. ACS central science 8 (2) (2022)
Joseph M Paggi, Julia A Belk, Scott A Hollingsworth, Nicolas Villanueva, Alexander S Powers, Mary J Clark, Augustine G Chemparathy, Jonathan E Tynan, Thomas K Lau, Roger K Sunahara, Ron O Dror
Leveraging nonstructural data to predict structures and affinities of protein-ligand complexes. Proceedings of the National Academy of Sciences of the United States of America 118 (51) (2022)
Chase A P Wood, Jinru Zhang, Deniz Aydin, Yan Xu, Benjamin J Andreone, Urs H Langen, Ron O Dror, Chenghua Gu, Liang Feng
Structure and mechanism of blood-brain-barrier lipid transporter MFSD2A. Nature 596 (7872) (2021)
Raphael J L Townshend, Stephan Eismann, Andrew M Watkins, Ramya Rangan, Masha Karelina, Rachel J Hagey, Ron O Dror
Geometric deep learning of RNA structure. Science (New York, N.Y.) 373 (6558) (2021)
Brendan Kelly, Scott A Hollingsworth, David C Blakemore, Robert M Owen, R Ian Storer, Nigel A Swain, Deniz Aydin, Rubben Torella, Joseph S Warmus, Ron O Dror
Delineating the Ligand-Receptor Interactions That Lead to Biased Signaling at the μ-Opioid Receptor. Journal of chemical information and modeling 61 (7) (2021)
Lei Han, Qianhui Qu, Deniz Aydin, Ouliana Panova, Michael J Robertson, Yan Xu, Ron O Dror, Georgios Skiniotis, Liang Feng
Structure and mechanism of the SGLT family of glucose transporters. Nature (2021)
Julian A Harris, Bryan Faust, Arisbel B Gondin, Marc André Dämgen, Carl-Mikael Suomivuori, Nicholas A Veldhuis, Yifan Cheng, Ron O Dror, David M Thal, Aashish Manglik
Selective G protein signaling driven by substance P-neurokinin receptor dynamics. Nature chemical biology (2021)
Christian B Billesbølle, Caleigh M Azumaya, Rachael C Kretsch, Alexander S Powers, Shane Gonen, Simon Schneider, Tara Arvedson, Ron O Dror, Yifan Cheng, Aashish Manglik
Structure of hepcidin-bound ferroportin reveals iron homeostatic mechanisms. Nature 586 (7831) (2020)
Laura M Wingler, Meredith A Skiba, Conor McMahon, Dean P Staus, Alissa L W Kleinhenz, Carl-Mikael Suomivuori, Naomi R Latorraca, Ron O Dror, Robert J Lefkowitz, Andrew C Kruse
Angiotensin and biased analogs induce structurally distinct active conformations within a GPCR. Science (New York, N.Y.) 367 (6480) (2020)
Stephan Eismann, Raphael J L Townshend, Nathaniel Thomas, Milind Jagota, Bowen Jing, Ron O Dror
Hierarchical, rotation-equivariant neural networks to select structural models of protein complexes. Proteins 89 (5) (2020)
Carl-Mikael Suomivuori, Naomi R Latorraca, Laura M Wingler, Stephan Eismann, Matthew C King, Alissa L W Kleinhenz, Meredith A Skiba, Dean P Staus, Andrew C Kruse, Robert J Lefkowitz, Ron O Dror
Molecular mechanism of biased signaling in a prototypical G protein-coupled receptor. Science (New York, N.Y.) 367 (6480) (2020)
A J Venkatakrishnan, Anthony K Ma, Rasmus Fonseca, Naomi R Latorraca, Brendan Kelly, Robin M Betz, Chaitanya Asawa, Brian K Kobilka, Ron O Dror
Diverse GPCRs exhibit conserved water networks for stabilization and activation. Proceedings of the National Academy of Sciences of the United States of America 116 (8) (2019)
Scott A Hollingsworth, Brendan Kelly, Celine Valant, Jordan Arthur Michaelis, Olivia Mastromihalis, Geoff Thompson, A J Venkatakrishnan, Samuel Hertig, Peter J Scammells, Patrick M Sexton, Christian C Felder, Arthur Christopoulos, Ron O Dror
Cryptic pocket formation underlies allosteric modulator selectivity at muscarinic GPCRs. Nature communications 10 (1) (2019)
Sheng Wang, Daniel Wacker, Anat Levit Kaplan, Tao Che, Robin M Betz, John D McCorvy, A J Venkatakrishnan, Xi-Ping Huang, Ron O Dror, Brian K Shoichet, Bryan L Roth
D4 dopamine receptor high-resolution structures enable the discovery of selective agonists. Science (New York, N.Y.) 358 (6361) (2018)
Ned Van Eps, Christian Altenbach, Lydia N Caro, Naomi R Latorraca, Scott A Hollingsworth, Ron O Dror, Oliver P Ernst, Wayne L Hubbell
Gi- and Gs-coupled GPCRs show different modes of G-protein binding. Proceedings of the National Academy of Sciences of the United States of America 115 (10) (2018)
Samuel Hertig, Naomi R Latorraca, Ron O Dror
Revealing Atomic-Level Mechanisms of Protein Allostery with Molecular Dynamics Simulations. PLoS computational biology 12 (6) (2016)