Andrew B Tobin (Andrew Tobin)

Publication Activity (10 Years)

Years Active: 2018-2024
Publications (10 Years): 24

Top Topics

Plasmodium Falciparum

Top Venues

ACS chemical neuroscience

Proceedings of the National Academy of Sciences of the United States of America

Nature chemical biology

This page only lists publications with an associated author ORCID identifier.

Publications

Andrew B Tobin
A golden age of muscarinic acetylcholine receptor modulation in neurological diseases. Nature reviews. Drug discovery (2024)
Ziva Vuckovic, Jinan Wang, Vi Pham, Jesse I Mobbs, Matthew J Belousoff, Apurba Bhattarai, Wessel A C Burger, Geoff Thompson, Mahmuda Yeasmin, Vindhya Nawaratne, Katie Leach, Emma T van der Westhuizen, Elham Khajehali, Yi-Lynn Liang, Alisa Glukhova, Denise Wootten, Craig W Lindsley, Andrew B Tobin, Patrick Sexton, Radostin Danev, Celine Valant, Yinglong Miao, Arthur Christopoulos, David M Thal
Pharmacological hallmarks of allostery at the M4 muscarinic receptor elucidated through structure and dynamics. eLife 12 (2023)
Wessel A C Burger, Vi Pham, Ziva Vuckovic, Alexander S Powers, Jesse I Mobbs, Yianni Laloudakis, Alisa Glukhova, Denise Wootten, Andrew B Tobin, Patrick M Sexton, Steven M Paul, Christian C Felder, Radostin Danev, Ron O Dror, Arthur Christopoulos, Celine Valant, David M Thal
Xanomeline displays concomitant orthosteric and allosteric binding modes at the M 4 mAChR. Nature communications 14 (1) (2023)
Natasja Barki, Laura Jenkins, Sara Marsango, Domonkos Dedeo, Daniele Bolognini, Louis Dwomoh, Aisha M Abdelmalik, Margaret Nilsen, Manon Stoffels, Falko Nagel, Stefan Schulz, Andrew B Tobin, Graeme Milligan
Phosphorylation bar-coding of free fatty acid receptor 2 is generated in a tissue-specific manner. eLife 12 (2023)
Natasja Barki, Daniele Bolognini, Ulf Börjesson, Laura Jenkins, John Riddell, David I Hughes, Trond Ulven, Brian D Hudson, Elisabeth Rexen Ulven, Niek Dekker, Andrew B Tobin, Graeme Milligan
Chemogenetics defines a short-chain fatty acid receptor gut-brain axis. eLife 11 (2022)
Sara Marsango, Laura Jenkins, John D Pediani, Sophie J Bradley, Richard J Ward, Sarah Hesse, Gabriel Biener, Michael R Stoneman, Andrew B Tobin, Valerica Raicu, Graeme Milligan
The M 1 muscarinic receptor is present in situ as a ligand-regulated mixture of monomers and oligomeric complexes. Proceedings of the National Academy of Sciences of the United States of America 119 (24) (2022)
Louis Dwomoh, Mario Rossi, Miriam Scarpa, Elham Khajehali, Colin Molloy, Pawel Herzyk, Shailesh N Mistry, Andrew R Bottrill, Patrick M Sexton, Arthur Christopoulos, P Jeffrey Conn, Dennis C Liotta, Sophie J Bradley, Andrew B Tobin
M 1 muscarinic receptor activation reduces the molecular pathology and slows the progression of prion-mediated neurodegenerative disease. Science signaling 15 (760) (2022)
Miriam Scarpa, Colin Molloy, Laura Jenkins, Bethany Strellis, Rebecca F Budgett, Sarah Hesse, Louis Dwomoh, Sara Marsango, Gonzalo S Tejeda, Mario Rossi, Zeshan Ahmed, Graeme Milligan, Brian D Hudson, Andrew B Tobin, Sophie J Bradley
Biased M1 muscarinic receptor mutant mice show accelerated progression of prion neurodegenerative disease. Proceedings of the National Academy of Sciences of the United States of America 118 (50) (2022)
Huong T M Nguyen, Emma T van der Westhuizen, Christopher J Langmead, Andrew B Tobin, Patrick M Sexton, Arthur Christopoulos, Celine Valant
Opportunities and challenges for the development of M 1 muscarinic receptor positive allosteric modulators in the treatment for neurocognitive deficits. British journal of pharmacology (2022)
Julie-Myrtille Bourgognon, Jereme G Spiers, Sue W Robinson, Hannah Scheiblich, Paul Glynn, Catharine Ortori, Sophie J Bradley, Andrew B Tobin, Joern R Steinert
Inhibition of neuroinflammatory nitric oxide signaling suppresses glycation and prevents neuronal dysfunction in mouse prion disease. Proceedings of the National Academy of Sciences of the United States of America 118 (10) (2021)
Rudi Prihandoko, Davinder Kaur, Coen H Wiegman, Elisa Alvarez-Curto, Chantal Donovan, Latifa Chachi, Trond Ulven, Martha R Tyas, Eloise Euston, Zhaoyang Dong, Abdulrahman Ghali M Alharbi, Richard Y Kim, Jack G Lowe, Philip M Hansbro, Kian Fan Chung, Christopher E Brightling, Graeme Milligan, Andrew B Tobin
Pathophysiological regulation of lung function by the free fatty acid receptor FFA4. Science translational medicine 12 (557) (2021)
Wessel A C Burger, Patrick R Gentry, Alice E Berizzi, Ziva Vuckovic, Emma T van der Westhuizen, Geoff Thompson, Mahmuda Yeasmin, Dennis C Liotta, Patrick M Sexton, Christopher J Langmead, Andrew B Tobin, Arthur Christopoulos, Celine Valant, David M Thal
Identification of a Novel Allosteric Site at the M5 Muscarinic Acetylcholine Receptor. ACS chemical neuroscience 12 (16) (2021)
Li-Chiung Lin, Tezz Quon, Susanna Engberg, Amanda E Mackenzie, Andrew B Tobin, Graeme Milligan
G Protein-Coupled Receptor GPR35 Suppresses Lipid Accumulation in Hepatocytes. ACS pharmacology & translational science 4 (6) (2021)
Laura Jenkins, Sara Marsango, Sarah Mancini, Zobaer Al Mahmud, Angus Morrison, Stuart P McElroy, Kirstie A Bennett, Matt Barnes, Andrew B Tobin, Irina G Tikhonova, Graeme Milligan
Discovery and Characterization of Novel Antagonists of the Proinflammatory Orphan Receptor GPR84. ACS pharmacology & translational science 4 (5) (2021)
Sachel Mok, Barbara H Stokes, Nina F Gnädig, Leila S Ross, Tomas Yeo, Chanaki Amaratunga, Erik Allman, Lev Solyakov, Andrew R Bottrill, Jaishree Tripathi, Rick M Fairhurst, Manuel Llinás, Zbynek Bozdech, Andrew B Tobin, David A Fidock
Artemisinin-resistant K13 mutations rewire Plasmodium falciparum's intra-erythrocytic metabolic program to enhance survival. Nature communications 12 (1) (2021)
Elisabeth Rexen Ulven, Tezz Quon, Eugenia Sergeev, Natasja Barki, Matjaz Brvar, Brian D Hudson, Palash Dutta, Anders Højgaard Hansen, Line Ø Bielefeldt, Andrew B Tobin, Christine Joy McKenzie, Graeme Milligan, Trond Ulven
Structure-Activity Relationship Studies of Tetrahydroquinolone Free Fatty Acid Receptor 3 Modulators. Journal of medicinal chemistry 63 (7) (2020)
Sophie J Bradley, Colin Molloy, Paulina Valuskova, Louis Dwomoh, Miriam Scarpa, Mario Rossi, Lisa Finlayson, Kjell A Svensson, Eyassu Chernet, Vanessa N Barth, Karolina Gherbi, David A Sykes, Caroline A Wilson, Rajendra Mistry, Patrick M Sexton, Arthur Christopoulos, Adrian J Mogg, Elizabeth M Rosethorne, Shuzo Sakata, R A John Challiss, Lisa M Broad, Andrew B Tobin
Biased M1-muscarinic-receptor-mutant mice inform the design of next-generation drugs. Nature chemical biology 16 (3) (2020)
Amit Mahindra, Omar Janha, Kopano Mapesa, Ana Sanchez-Azqueta, Mahmood M Alam, Alfred Amambua-Ngwa, Davis C Nwakanma, Andrew B Tobin, Andrew G Jamieson
Development of Potent PfCLK3 Inhibitors Based on TCMDC-135051 as a New Class of Antimalarials. Journal of medicinal chemistry 63 (17) (2020)
Elham Khajehali, Sophie J Bradley, Emma T van der Westhuizen, Colin Molloy, Celine Valant, Lisa Finlayson, Dennis C Liotta, Patrick M Sexton, Andrew B Tobin, Arthur Christopoulos
Restoring Agonist Function at a Chemogenetically Modified M1 Muscarinic Acetylcholine Receptor. ACS chemical neuroscience 11 (24) (2020)
Mahmood M Alam, Ana Sanchez-Azqueta, Omar Janha, Erika L Flannery, Amit Mahindra, Kopano Mapesa, Aditya B Char, Dev Sriranganadane, Nicolas M B Brancucci, Yevgeniya Antonova-Koch, Kathryn Crouch, Nelson Victor Simwela, Scott B Millar, Jude Akinwale, Deborah Mitcheson, Lev Solyakov, Kate Dudek, Carolyn Jones, Cleofé Zapatero, Christian Doerig, Davis C Nwakanma, Maria Jesús Vázquez, Gonzalo Colmenarejo, Maria Jose Lafuente-Monasterio, Maria Luisa Leon, Paulo H C Godoi, Jonathan M Elkins, Andrew P Waters, Andrew G Jamieson, Elena Fernández Álvaro, Lisa C Ranford-Cartwright, Matthias Marti, Elizabeth A Winzeler, Francisco Javier Gamo, Andrew B Tobin
Validation of the protein kinase PfCLK3 as a multistage cross-species malarial drug target. Science (New York, N.Y.) 365 (6456) (2020)
Maria Marti-Solano, Stephanie E Crilly, Duccio Malinverni, Christian Munk, Matthew Harris, Abigail Pearce, Tezz Quon, Amanda E Mackenzie, Xusheng Wang, Junmin Peng, Andrew B Tobin, Graham Ladds, Graeme Milligan, David E Gloriam, Manojkumar A Puthenveedu, M Madan Babu
Author Correction: Combinatorial expression of GPCR isoforms affects signalling and drug responses. Nature (2020)
Maria Marti-Solano, Stephanie E Crilly, Duccio Malinverni, Christian Munk, Matthew Harris, Abigail Pearce, Tezz Quon, Amanda E Mackenzie, Xusheng Wang, Junmin Peng, Andrew B Tobin, Graham Ladds, Graeme Milligan, David E Gloriam, Manojkumar A Puthenveedu, M Madan Babu
Combinatorial expression of GPCR isoforms affects signalling and drug responses. Nature 587 (7835) (2020)
Daniele Bolognini, Natasja Barki, Adrian J Butcher, Brian D Hudson, Eugenia Sergeev, Colin Molloy, Catherine E Moss, Sophie J Bradley, Christian Le Gouill, Michel Bouvier, Andrew B Tobin, Graeme Milligan
Chemogenetics defines receptor-mediated functions of short chain free fatty acids. Nature chemical biology 15 (5) (2019)
Manuela Jörg, Emma T van der Westhuizen, Elham Khajehali, Wessel A C Burger, Jonathan M White, Kwok H C Choy, Andrew B Tobin, Patrick M Sexton, Celine Valant, Ben Capuano, Arthur Christopoulos, Peter J Scammells
6-Phenylpyrimidin-4-ones as Positive Allosteric Modulators at the M1 mAChR: The Determinants of Allosteric Activity. ACS chemical neuroscience 10 (3) (2018)