Fabrizio Giordanetto

Publication Activity (10 Years)

Years Active: 2019-2023
Publications (10 Years): 13

Top Topics

Molecular Dynamics Simulations

Protein Protein

Top Venues

Journal of chemical information and modeling

Journal of medicinal chemistry

Journal of the American Chemical Society

ACS medicinal chemistry letters

This page only lists publications with an associated author ORCID identifier.

Publications

Alexander M Taylor, Bret R Williams, Fabrizio Giordanetto, Elizabeth H Kelley, André Lescarbeau, Kelley Shortsleeves, Yong Tang, W Patrick Walters, Alfonso Arrazate, Christine Bowman, Erin Brophy, Emily W Chan, Gauri Deshmukh, Jack B Greisman, Thomas L Hunsaker, D Randal Kipp, Pablo Saenz Lopez-Larrocha, Danilo Maddalo, Iain J Martin, Paul Maragakis, Mark Merchant, Mark Murcko, Hunter M Nisonoff, Vi Nguyen, Vy Nguyen, Olivia Orozco, Christopher Owen, Levi Pierce, Molly Schmidt, David E Shaw, Sherri Smith, Eric Therrien, John C Tran, Jim Watters, Nigel J Waters, Jeremy Wilbur, Lindsay Willmore
Identification of GDC-1971 (RLY-1971), a SHP2 Inhibitor Designed for the Treatment of Solid Tumors. Journal of medicinal chemistry (2023)
Jack B Greisman, Lindsay Willmore, Christine Yiwen Yeh, Fabrizio Giordanetto, Sahar Shahamadtar, Hunter Nisonoff, Paul Maragakis, David E Shaw
Discovery and Validation of the Binding Poses of Allosteric Fragment Hits to Protein Tyrosine Phosphatase 1b: From Molecular Dynamics Simulations to X-ray Crystallography. Journal of chemical information and modeling 63 (9) (2023)
Jack B Greisman, Lindsay Willmore, Christine Yiwen Yeh, Fabrizio Giordanetto, Sahar Shahamadtar, Hunter Nisonoff, Paul Maragakis, David E Shaw
Discovery and Validation of the Binding Poses of Allosteric Fragment Hits to Protein Tyrosine Phosphatase 1b: From Molecular Dynamics Simulations to X-ray Crystallography. Journal of chemical information and modeling (2023)
Andreas Varkaris, Ermira Pazolli, Hakan Gunaydin, Qi Wang, Levi Pierce, Alessandro A Boezio, Lucian DiPietro, Adam Frost, Fabrizio Giordanetto, Erika Paige Hamilton, Katherine Harris, Michael J Holliday, Tamieka L Hunter, Amanda Iskandar, Yongli Ji, Alexandre Larivée, Jonathan R LaRochelle, Andre Lescarbeau, Fabien Llambi, Brenda Lormil, Mary M Mader, Brenton G Mar, Iain Martin, Thomas H McLean, Klaus Michelsen, Yakov Pechersky, Erika G Puente, Ramin Samadani, Alison M Schram, Kelley Shortsleeves, Sweta Swaminathan, Shahein Tajmir, Gege Tan, Yong Tang, Roberto Valverde, Bryan Wehrenberg, Jeremy Wilbur, Bret R Williams, Hongtao Zeng, W Patrick Walters, Beni B Wolf, David E Shaw, Donald A Bergstrom, James Watters, Brian K Shoichet, Pascal D Fortin, D Randal Kipp
Discovery and clinical proof-of-concept of RLY-2608, a first-in-class mutant-selective allosteric PI3Ka inhibitor that decouples anti-tumor activity from hyperinsulinemia. Cancer discovery (2023)
Jack B Greisman, Lindsay Willmore, Christine Yiwen Yeh, Fabrizio Giordanetto, Sahar Shahamadtar, Hunter Nisonoff, Paul Maragakis, David E Shaw
Discovery and Validation of the Binding Poses of Allosteric Fragment Hits to Protein Tyrosine Phosphatase 1b: From Molecular Dynamics Simulations to X-ray Crystallography. Journal of chemical information and modeling 63 (9) (2023)
Jack B Greisman, Lindsay Willmore, Christine Yiwen Yeh, Fabrizio Giordanetto, Sahar Shahamadtar, Hunter Nisonoff, Paul Maragakis, David E Shaw
Discovery and Validation of the Binding Poses of Allosteric Fragment Hits to Protein Tyrosine Phosphatase 1b: From Molecular Dynamics Simulations to X-ray Crystallography. Journal of chemical information and modeling (2023)
Jack B Greisman, Lindsay Willmore, Christine Yiwen Yeh, Fabrizio Giordanetto, Sahar Shahamadtar, Hunter Nisonoff, Paul Maragakis, David E Shaw
Discovery and Validation of the Binding Poses of Allosteric Fragment Hits to Protein Tyrosine Phosphatase 1b: From Molecular Dynamics Simulations to X-ray Crystallography. Journal of chemical information and modeling (2023)
Jack B Greisman, Lindsay Willmore, Christine Yiwen Yeh, Fabrizio Giordanetto, Sahar Shahamadtar, Hunter Nisonoff, Paul Maragakis, David E Shaw
Discovery and Validation of the Binding Poses of Allosteric Fragment Hits to Protein Tyrosine Phosphatase 1b: From Molecular Dynamics Simulations to X-ray Crystallography. Journal of chemical information and modeling 63 (9) (2023)
Jack B Greisman, Lindsay Willmore, Christine Yiwen Yeh, Fabrizio Giordanetto, Sahar Shahamadtar, Hunter Nisonoff, Paul Maragakis, David E Shaw
Discovery and Validation of the Binding Poses of Allosteric Fragment Hits to Protein Tyrosine Phosphatase 1b: From Molecular Dynamics Simulations to X-ray Crystallography. Journal of chemical information and modeling 63 (9) (2023)
Gavin O'Mahony, Jens Petersen, Margareta Ek, Rebecca Rae, Carina Johansson, Liu Jianming, Nina Prokoph, Fredrik Bergström, Krister Bamberg, Fabrizio Giordanetto, Bader Zarrouki, Daniel Karlsson, Anders Hogner
Discovery by Virtual Screening of an Inhibitor of CDK5-Mediated PPARγ Phosphorylation. ACS medicinal chemistry letters 13 (4) (2022)
Paul Robustelli, Alain Ibanez-de-Opakua, Cecily Campbell-Bezat, Fabrizio Giordanetto, Stefan Becker, Markus Zweckstetter, Albert C Pan, David E Shaw
Molecular Basis of Small-Molecule Binding to α-Synuclein. Journal of the American Chemical Society 144 (6) (2022)
Fabrizio Giordanetto, Chentian Jin, Lindsay Willmore, Miklos Feher, David E Shaw
Fragment Hits: What do They Look Like and How do They Bind? Journal of medicinal chemistry 62 (7) (2019)
Silvia Stotani, Viviana Gatta, Prasanthi Medarametla, Mohan Padmanaban, Anna Karawajczyk, Fabrizio Giordanetto, Päivi Tammela, Tuomo Laitinen, Antti Poso, Dimitros Tzalis, Simona Collina
DPD-Inspired Discovery of Novel LsrK Kinase Inhibitors: An Opportunity To Fight Antimicrobial Resistance. Journal of medicinal chemistry 62 (5) (2019)