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Markus Zweckstetter (M Zweckstetter)

ORCID

Publication Activity (10 Years)

Years Active: 2016-2023
Publications (10 Years): 63

Top Venues

Nature communications

Science advances

Angewandte Chemie (International ed. in English)

Protein science : a publication of the Protein Society

Max Planck Institute of Biochemistry (PHD)

This page only lists publications with an associated author ORCID identifier.

Education History

Max Planck Institute of Biochemistry Mar 1o 1996 - Dec 15o 1998

Germany

PHD

Publications

Christian F Pantoja, Alain Ibáñez de Opakua, Maria-Sol Cima-Omori, Markus Zweckstetter
Determining the Physico-Chemical Composition of Biomolecular Condensates from Spatially-Resolved NMR. Angewandte Chemie (International ed. in English) (2023)
Irina P Lushpinskaia, David Flores-Solis, Markus Zweckstetter
Structure and phase separation of the C-terminal domain of RNA polymerase II. Biological chemistry (2023)
Taekyung Yu, David Flores-Solis, Gunnar N Eastep, Stefan Becker, Markus Zweckstetter
Phosphatidylserine-dependent structure of synaptogyrin remodels the synaptic vesicle membrane. Nature structural & molecular biology (2023)
Lulu Jiang, Pijush Chakraborty, Lushuang Zhang, Melissa Wong, Shannon E Hill, Chelsea Joy Webber, Jenna Libera, Laura J Blair, Benjamin Wolozin, Markus Zweckstetter
Chaperoning of specific tau structure by immunophilin FKBP12 regulates the neuronal resilience to extracellular stress. Science advances 9 (5) (2023)
Tina Ukmar-Godec, Maria-Sol Cima-Omori, Zhadyra Yerkesh, Karthik Eswara, Taekyung Yu, Reshma Ramesh, Gwladys Riviere, Alain Ibanez de Opakua, Wolfgang Fischle, Markus Zweckstetter
Multimodal interactions drive chromatin phase separation and compaction. Proceedings of the National Academy of Sciences of the United States of America 120 (50) (2023)
Rita Rosado-Ramos, Gonçalo M Poças, Daniela Marques, Alexandre Foito, David M Sevillano, Mafalda Lopes-da-Silva, Luís G Gonçalves, Regina Menezes, Marcel Ottens, Derek Stewart, Alain Ibáñez de Opakua, Markus Zweckstetter, Miguel C Seabra, César S Mendes, Tiago Fleming Outeiro, Pedro M Domingos, Claudia Nunes Dos Santos
Genipin prevents alpha-synuclein aggregation and toxicity by affecting endocytosis, metabolism and lipid storage. Nature communications 14 (1) (2023)
Lulu Jiang, Pijush Chakraborty, Lushuang Zhang, Melissa Wong, Shannon E Hill, Chelsea Joy Webber, Jenna Libera, Laura J Blair, Benjamin Wolozin, Markus Zweckstetter
Chaperoning of specific tau structure by immunophilin FKBP12 regulates the neuronal resilience to extracellular stress. Science advances 9 (5) (2023)
Shuyu Zhang, Karina Dauer, Timo Strohäker, Lars Tatenhorst, L Caldi Gomes, Simon Mayer, Byung Chul Jung, Woojin S Kim, Seung-Jae Lee, Stefan Becker, Friederike Liesche-Starnecker, Markus Zweckstetter, Paul Lingor
Alpha-synuclein fibrils amplified from multiple system atrophy and Parkinson's disease patient brain spread after intracerebral injection into mouse brain. Brain pathology (Zurich, Switzerland) (2023)
Zheng Shen, Daxiao Sun, Adriana Savastano, Sára Joana Varga, Maria-Sol Cima-Omori, Stefan Becker, Alf Honigmann, Markus Zweckstetter
Multivalent Tau/PSD-95 interactions arrest in vitro condensates and clusters mimicking the postsynaptic density. Nature communications 14 (1) (2023)
Lulu Jiang, Pijush Chakraborty, Lushuang Zhang, Melissa Wong, Shannon E Hill, Chelsea Joy Webber, Jenna Libera, Laura J Blair, Benjamin Wolozin, Markus Zweckstetter
Chaperoning of specific tau structure by immunophilin FKBP12 regulates the neuronal resilience to extracellular stress. Science advances 9 (5) (2023)
David Flores-Solis, Irina P Lushpinskaia, Anton A Polyansky, Arya Changiarath, Marc Boehning, Milana Mirkovic, James Walshe, Lisa M Pietrek, Patrick Cramer, Lukas S Stelzl, Bojan Zagrovic, Markus Zweckstetter
Driving forces behind phase separation of the carboxy-terminal domain of RNA polymerase II. Nature communications 14 (1) (2023)
Yongqi Huang, Jitao Wen, Lisa-Marie Ramirez, Eymen Gümüşdil, Pravin Pokhrel, Viet H Man, Haiqiong Ye, Yue Han, Yunfei Liu, Ping Li, Zhengding Su, Junmei Wang, Han-Bin Mao, Markus Zweckstetter, Sarah Perrett, Si Wu, Meng Gao
Methylene blue accelerates liquid-to-gel transition of tau condensates impacting tau function and pathology. Nature communications 14 (1) (2023)
Anton Abyzov, Eckhard Mandelkow, Markus Zweckstetter, Nasrollah Rezaei-Ghaleh
Fast Motions Dominate Dynamics of Intrinsically Disordered Tau Protein at High Temperatures. Chemistry (Weinheim an der Bergstrasse, Germany) 29 (17) (2023)
Lulu Jiang, Pijush Chakraborty, Lushuang Zhang, Melissa Wong, Shannon E Hill, Chelsea Joy Webber, Jenna Libera, Laura J Blair, Benjamin Wolozin, Markus Zweckstetter
Chaperoning of specific tau structure by immunophilin FKBP12 regulates the neuronal resilience to extracellular stress. Science advances 9 (5) (2023)
Lulu Jiang, Pijush Chakraborty, Lushuang Zhang, Melissa Wong, Shannon E Hill, Chelsea Joy Webber, Jenna Libera, Laura J Blair, Benjamin Wolozin, Markus Zweckstetter
Chaperoning of specific tau structure by immunophilin FKBP12 regulates the neuronal resilience to extracellular stress. Science advances 9 (5) (2023)
Pijush Chakraborty, Gwladys Rivière, Alina S Hebestreit, Alain Ibáñez de Opakua, Ina Maja Vorberg, Loren B Andreas, Markus Zweckstetter
Acetylation discriminates disease-specific tau deposition. Nature communications 14 (1) (2023)
Anton Abyzov, Eckhard Mandelkow, Markus Zweckstetter, Nasrollah Rezaei-Ghaleh
Fast Motions Dominate Dynamics of Intrinsically Disordered Tau Protein at High Temperatures. Chemistry (Weinheim an der Bergstrasse, Germany) 29 (17) (2023)
Lukas S Stelzl, Lisa M Pietrek, Andrea Holla, Javier Oroz, Mateusz Sikora, Jürgen Köfinger, Benjamin Schuler, Markus Zweckstetter, Gerhard Hummer
Global Structure of the Intrinsically Disordered Protein Tau Emerges from Its Local Structure. JACS Au 2 (3) (2022)
Anton Abyzov, Martin Blackledge, Markus Zweckstetter
Conformational Dynamics of Intrinsically Disordered Proteins Regulate Biomolecular Condensate Chemistry. Chemical reviews 122 (6) (2022)
Alain Ibáñez de Opakua, James A Geraets, Benedikt Frieg, Christian Dienemann, Adriana Savastano, Marija Rankovic, Maria-Sol Cima-Omori, Gunnar F Schröder, Markus Zweckstetter
Molecular interactions of FG nucleoporin repeats at high resolution. Nature chemistry 14 (11) (2022)
Anton Abyzov, Eckhard Mandelkow, Markus Zweckstetter, Nasrollah Rezaei-Ghaleh
Fast Motions Dominate Dynamics of Intrinsically Disordered Tau Protein at High Temperatures. Chemistry (Weinheim an der Bergstrasse, Germany) (2022)
Alisa Cario, Adriana Savastano, Neil B Wood, Zhu Liu, Michael J Previs, Adam G Hendricks, Markus Zweckstetter, Christopher L Berger
The pathogenic R5L mutation disrupts formation of Tau complexes on the microtubule by altering local N-terminal structure. Proceedings of the National Academy of Sciences of the United States of America 119 (7) (2022)
Antonia Moll, Lisa Marie Ramirez, Momchil Ninov, Juliane Schwarz, Henning Urlaub, Markus Zweckstetter
Hsp multichaperone complex buffers pathologically modified Tau. Nature communications 13 (1) (2022)
Benedikt Frieg, James A Geraets, Timo Strohäker, Christian Dienemann, Panagiota Mavroeidi, Byung Chul Jung, Woojin Scott Kim, Seung-Jae Lee, Maria Xilouri, Markus Zweckstetter, Gunnar F Schröder
Quaternary structure of patient-homogenate amplified α-synuclein fibrils modulates seeding of endogenous α-synuclein. Communications biology 5 (1) (2022)
Milan Zachrdla, Adriana Savastano, Alain Ibáñez de Opakua, Maria-Sol Cima-Omori, Markus Zweckstetter
Contributions of the N-terminal intrinsically disordered region of the severe acute respiratory syndrome coronavirus 2 nucleocapsid protein to RNA-induced phase separation. Protein science : a publication of the Protein Society 31 (9) (2022)
Senthil T Kumar, Anne-Laure Mahul-Mellier, Ramanath Narayana Hegde, Gwladys Riviere, Rani Moons, Alain Ibáñez de Opakua, Pedro Magalhães, Iman Rostami, Sonia Donzelli, Frank Sobott, Markus Zweckstetter, Hilal A Lashuel
A NAC domain mutation (E83Q) unlocks the pathogenicity of human alpha-synuclein and recapitulates its pathological diversity. Science advances 8 (17) (2022)
Maria Babu, Filippo Favretto, Marija Rankovic, Markus Zweckstetter
Peptidyl Prolyl Isomerase A Modulates the Liquid-Liquid Phase Separation of Proline-Rich IDPs. Journal of the American Chemical Society 144 (35) (2022)
Pijush Chakraborty, Markus Zweckstetter
Phase separation of the microtubule-associated protein tau. Essays in biochemistry (2022)
Paul Robustelli, Alain Ibanez-de-Opakua, Cecily Campbell-Bezat, Fabrizio Giordanetto, Stefan Becker, Markus Zweckstetter, Albert C Pan, David E Shaw
Molecular Basis of Small-Molecule Binding to α-Synuclein. Journal of the American Chemical Society 144 (6) (2022)
Christian F Pantoja, Markus Zweckstetter, Nasrollah Rezaei-Ghaleh
Dynamical component exchange in a model phase separating system: an NMR-based approach. Physical chemistry chemical physics : PCCP 24 (10) (2022)
Maria Babu, Filippo Favretto, Alain Ibáñez de Opakua, Marija Rankovic, Stefan Becker, Markus Zweckstetter
Proline/arginine dipeptide repeat polymers derail protein folding in amyotrophic lateral sclerosis. Nature communications 12 (1) (2021)
Luis M A Oliveira, Thomas Gasser, Robert Edwards, Markus Zweckstetter, Ronald Melki, Leonidas Stefanis, Hilal A Lashuel, David L Sulzer, Kostas Vekrellis, Glenda M Halliday, Julianna J Tomlinson, Michael G Schlossmacher, Poul Henning Jensen, Julia Schulze-Hentrich, Olaf Riess, Warren D Hirst, Omar El-Agnaf, Brit Mollenhauer, Peter Lansbury, Tiago Fleming Outeiro
Alpha-synuclein research: defining strategic moves in the battle against Parkinson's disease. NPJ Parkinson's disease 7 (1) (2021)
Markus Zweckstetter, Alexander Dityatev, Evgeni G Ponimaskin
Structure of serotonin receptors: molecular underpinning of receptor activation and modulation. Signal transduction and targeted therapy 6 (1) (2021)
Markus Zweckstetter
Introduction: Biophysics of biomolecular condensates. Protein science : a publication of the Protein Society 30 (7) (2021)
Anna Siegert, Marija Rankovic, Filippo Favretto, Tina Ukmar-Godec, Timo Strohäker, Stefan Becker, Markus Zweckstetter
Interplay between tau and α-synuclein liquid-liquid phase separation. Protein science : a publication of the Protein Society 30 (7) (2021)
Sandeep K Rai, Adriana Savastano, Priyanka Singh, Samrat Mukhopadhyay, Markus Zweckstetter
Liquid-liquid phase separation of tau: From molecular biophysics to physiology and disease. Protein science : a publication of the Protein Society 30 (7) (2021)
Pijush Chakraborty, Gwladys Rivière, Shu Liu, Alain Ibáñez de Opakua, Riza Dervişoğlu, Alina Hebestreit, Loren B Andreas, Ina Maja Vorberg, Markus Zweckstetter
Co-factor-free aggregation of tau into seeding-competent RNA-sequestering amyloid fibrils. Nature communications 12 (1) (2021)
Markus Zweckstetter
NMR hawk-eyed view of AlphaFold2 structures. Protein science : a publication of the Protein Society 30 (11) (2021)
Florian Hamann, Andreas Schmitt, Filippo Favretto, Romina Hofele, Piotr Neumann, ShengQi Xiang, Henning Urlaub, Markus Zweckstetter, Ralf Ficner
Structural analysis of the intrinsically disordered splicing factor Spp2 and its binding to the DEAH-box ATPase Prp2. Proceedings of the National Academy of Sciences of the United States of America 117 (6) (2020)
Antonia Lott, Javier Oroz, Markus Zweckstetter
Molecular basis of the interaction of Hsp90 with its co-chaperone Hop. Protein science : a publication of the Protein Society 29 (12) (2020)
Tina Ukmar-Godec, P Fang, Alain Ibáñez de Opakua, Fabian Henneberg, Aljaž Godec, Kuan-Ting Pan, M-S Cima-Omori, Ashwin Chari, Eckhard Mandelkow, H Urlaub, Markus Zweckstetter
Proteasomal degradation of the intrinsically disordered protein tau at single-residue resolution. Science advances 6 (30) (2020)
Adriana Savastano, Alain Ibáñez de Opakua, Marija Rankovic, Markus Zweckstetter
Nucleocapsid protein of SARS-CoV-2 phase separates into RNA-rich polymerase-containing condensates. Nature communications 11 (1) (2020)
Gwladys Rivière, Garima Jaipuria, Loren B Andreas, Andrei Leonov, Karin Giller, Stefan Becker, Markus Zweckstetter
Membrane-embedded TSPO: an NMR view. European biophysics journal : EBJ 50 (2) (2020)
Filippo Favretto, Jeremy D Baker, Timo Strohäker, Loren B Andreas, Laura J Blair, Stefan Becker, Markus Zweckstetter
The Molecular Basis of the Interaction of Cyclophilin A with α-Synuclein. Angewandte Chemie (International ed. in English) 59 (14) (2020)
Adriana Savastano, David Flores, Harindranath Kadavath, Jacek Biernat, Eckhard Mandelkow, Markus Zweckstetter
Disease-Associated Tau Phosphorylation Hinders Tubulin Assembly within Tau Condensates. Angewandte Chemie (International ed. in English) 60 (2) (2020)
Alain Ibáñez de Opakua, Frederik Klama, Ikenna E Ndukwe, Gary E Martin, R Thomas Williamson, Markus Zweckstetter
Determination of Complex Small-Molecule Structures Using Molecular Alignment Simulation. Angewandte Chemie (International ed. in English) 59 (15) (2020)
Susmitha Ambadipudi, Jithender G Reddy, Jacek Biernat, Eckhard Mandelkow, Markus Zweckstetter
Residue-specific identification of phase separation hot spots of Alzheimer's-related protein tau. Chemical science 10 (26) (2019)
Timo Strohäker, Byung Chul Jung, Shu-Hao Liou, Claudio O Fernandez, Dietmar Riedel, Stefan Becker, Glenda M Halliday, Marina Bennati, Woojin Scott Kim, Seung-Jae Lee, Markus Zweckstetter
Structural heterogeneity of α-synuclein fibrils amplified from patient brain extracts. Nature communications 10 (1) (2019)
Jing Gong, Éva M Szego, Andrei Leonov, Eva Benito, Stefan Becker, Andre Fischer, Markus Zweckstetter, Tiago Fleming Outeiro, Anja Schneider
Translocator Protein Ligand Protects against Neurodegeneration in the MPTP Mouse Model of Parkinsonism. The Journal of neuroscience : the official journal of the Society for Neuroscience 39 (19) (2019)
Nasrollah Rezaei-Ghaleh, Giacomo Parigi, Markus Zweckstetter
Reorientational Dynamics of Amyloid-β from NMR Spin Relaxation and Molecular Simulation. The journal of physical chemistry letters 10 (12) (2019)
Harindranath Kadavath, Yunior Cabrales Fontela, Mariusz Jaremko, Łukasz Jaremko, Kerstin Overkamp, Jacek Biernat, Eckhard Mandelkow, Markus Zweckstetter
The Binding Mode of a Tau Peptide with Tubulin. Angewandte Chemie (International ed. in English) 57 (12) (2018)
Garima Jaipuria, Tina Ukmar-Godec, Markus Zweckstetter
Challenges and approaches to understand cholesterol-binding impact on membrane protein function: an NMR view. Cellular and molecular life sciences : CMLS 75 (12) (2018)
Garima Jaipuria, Karin Giller, Andrei Leonov, Stefan Becker, Markus Zweckstetter
Insights into Cholesterol/Membrane Protein Interactions Using Paramagnetic Solid-State NMR. Chemistry (Weinheim an der Bergstrasse, Germany) 24 (66) (2018)
Marc Boehning, Claire Dugast-Darzacq, Marija Rankovic, Anders S Hansen, Taekyung Yu, Herve Marie-Nelly, David T McSwiggen, Goran Kokic, Gina M Dailey, Patrick Cramer, Xavier Darzacq, Markus Zweckstetter
RNA polymerase II clustering through carboxy-terminal domain phase separation. Nature structural & molecular biology 25 (9) (2018)
Kateřina Melková, Vojtěch Zapletal, Séverine Jansen, Erik Nomilner, Milan Zachrdla, Jozef Hritz, Jiří Nováček, Markus Zweckstetter, Malene R Jensen, Martin Blackledge, Lukáš Žídek
Functionally specific binding regions of microtubule-associated protein 2c exhibit distinct conformations and dynamics. The Journal of biological chemistry 293 (34) (2018)
Javier Oroz, Bliss J Chang, Piotr Wysoczanski, Chung-Tien Lee, Angel Perez-Lara, Pijush Chakraborty, Romina V Hofele, Jeremy D Baker, Laura J Blair, Jacek Biernat, Henning Urlaub, Eckhard Mandelkow, Chad A Dickey, Markus Zweckstetter
Structure and pro-toxic mechanism of the human Hsp90/PPIase/Tau complex. Nature communications 9 (1) (2018)
Nasrollah Rezaei-Ghaleh, Giacomo Parigi, Andrea Soranno, Andrea Holla, Stefan Becker, Benjamin Schuler, Claudio Luchinat, Markus Zweckstetter
Local and Global Dynamics in Intrinsically Disordered Synuclein. Angewandte Chemie (International ed. in English) 57 (46) (2018)
Sue-Ann Mok, Carlo Condello, Rebecca Freilich, Anne Gillies, Taylor Arhar, Javier Oroz, Harindranath Kadavath, Olivier Julien, Victoria A Assimon, Jennifer N Rauch, Bryan M Dunyak, Jungsoon Lee, Francis T F Tsai, Mark R Wilson, Markus Zweckstetter, Chad A Dickey, Jason E Gestwicki
Mapping interactions with the chaperone network reveals factors that protect against tau aggregation. Nature structural & molecular biology 25 (5) (2018)
Yunior Cabrales Fontela, Harindranath Kadavath, Jacek Biernat, Dietmar Riedel, Eckhard Mandelkow, Markus Zweckstetter
Multivalent cross-linking of actin filaments and microtubules through the microtubule-associated protein Tau. Nature communications 8 (1) (2017)
Javier Oroz, Jin Hae Kim, Bliss J Chang, Markus Zweckstetter
Mechanistic basis for the recognition of a misfolded protein by the molecular chaperone Hsp90. Nature structural & molecular biology 24 (4) (2017)
Susmitha Ambadipudi, Jacek Biernat, Dietmar Riedel, Eckhard Mandelkow, Markus Zweckstetter
Liquid-liquid phase separation of the microtubule-binding repeats of the Alzheimer-related protein Tau. Nature communications 8 (1) (2017)
Luis Fonseca-Ornelas, Carla Schmidt, Aldo R Camacho-Zarco, Claudio O Fernandez, Stefan Becker, Markus Zweckstetter
Small-Molecule-Induced Soluble Oligomers of α-Synuclein with Helical Structure. Chemistry (Weinheim an der Bergstrasse, Germany) 23 (53) (2017)
Jin Hae Kim, Javier Oroz, Markus Zweckstetter
Structure of Monomeric Transthyretin Carrying the Clinically Important T119M Mutation. Angewandte Chemie (International ed. in English) 55 (52) (2016)

Markus Zweckstetter.css-eqlu8i{font-size:small;padding-left:4px;} (M Zweckstetter)

Publication Activity (10 Years)

Top Topics

Top Venues

Markus Zweckstetter (M Zweckstetter)