Hakan Gunaydin

Publication Activity (10 Years)

Years Active: 2021-2023
Publications (10 Years): 5

Top Topics

Tyrosine Kinase

Nitric Oxide Synthase

Pluripotent Stem Cells

Top Venues

Cancer discovery

Journal of medicinal chemistry

ACS medicinal chemistry letters

This page only lists publications with an associated author ORCID identifier.

Publications

Vivek Subbiah, Vaibhav Sahai, Dejan Maglic, Kamil Bruderek, B Barry Toure, Songping Zhao, Roberto Valverde, Patrick J O'Hearn, Demetri T Moustakas, Heike Schonherr, Nastaran Gerami-Moayed, Alexander M Taylor, Brandi M Hudson, Damian J Houde, Debjani Pal, Lindsey Foster, Hakan Gunaydin, Pelin Ayaz, Dina A Sharon, Lipika Goyal, Alison M Schram, Suneel D Kamath, Cori Ann Sherwin, Oleg Schmidt-Kittler, Kai Yu Jen, Fabien Ricard, Beni B Wolf, David E Shaw, Donald A Bergstrom, James Watters, Jessica B Casaletto
RLY-4008, the first highly selective FGFR2 inhibitor with activity across FGFR2 alterations and resistance mutations. Cancer discovery (2023)
Andreas Varkaris, Ermira Pazolli, Hakan Gunaydin, Qi Wang, Levi Pierce, Alessandro A Boezio, Lucian DiPietro, Adam Frost, Fabrizio Giordanetto, Erika Paige Hamilton, Katherine Harris, Michael J Holliday, Tamieka L Hunter, Amanda Iskandar, Yongli Ji, Alexandre Larivée, Jonathan R LaRochelle, Andre Lescarbeau, Fabien Llambi, Brenda Lormil, Mary M Mader, Brenton G Mar, Iain Martin, Thomas H McLean, Klaus Michelsen, Yakov Pechersky, Erika G Puente, Ramin Samadani, Alison M Schram, Kelley Shortsleeves, Sweta Swaminathan, Shahein Tajmir, Gege Tan, Yong Tang, Roberto Valverde, Bryan Wehrenberg, Jeremy Wilbur, Bret R Williams, Hongtao Zeng, W Patrick Walters, Beni B Wolf, David E Shaw, Donald A Bergstrom, James Watters, Brian K Shoichet, Pascal D Fortin, D Randal Kipp
Discovery and clinical proof-of-concept of RLY-2608, a first-in-class mutant-selective allosteric PI3Ka inhibitor that decouples anti-tumor activity from hyperinsulinemia. Cancer discovery (2023)
Andreas Varkaris, Ferran Fece de la Cruz, Elizabeth E Martin, Bryanna L Norden, Nicholas Chevalier, Allison M Kehlmann, Ignaty Leshchiner, Haley Barnes, Sara Ehnstrom, Anastasia-Maria Stavridi, Xin Yuan, Janice S Kim, Haley Ellis, Alkistis Papatheodoridi, Hakan Gunaydin, Brian P Danysh, Laxmi Parida, Ioannis Sanidas, Yongli Ji, Kayao Lau, Gerburg M Wulf, Aditya Bardia, Laura M Spring, Steven Jay Isakoff, Jochen K Lennerz, Levi Pierce, Ermira Pazolli, Gad A Getz, Ryan B Corcoran, Dejan Juric
Allosteric PI3K-alpha inhibition overcomes on-target resistance to orthosteric inhibitors mediated by secondary PIK3CA mutations. Cancer discovery (2023)
David A Candito, Vladimir Simov, Anmol Gulati, Solomon D Kattar, Ryan W Chau, Blair T Lapointe, Joey L Methot, Duane E DeMong, Thomas H Graham, Ravi Kurukulasuriya, Mitchell H Keylor, Ling Tong, Gregori J Morriello, John J Acton, Barbara Pio, Weiguo Liu, Jack D Scott, Michael J Ardolino, Theodore A Martinot, Matthew L Maddess, Xin Yan, Hakan Gunaydin, Rachel L Palte, Spencer E McMinn, Lisa Nogle, Hongshi Yu, Ellen C Minnihan, Charles A Lesburg, Ping Liu, Jing Su, Laxminarayan G Hegde, Lily Y Moy, Janice D Woodhouse, Robert Faltus, Tina Xiong, Paul Ciaccio, Jennifer A Piesvaux, Karin M Otte, Matthew E Kennedy, David Jonathan Bennett, Erin F DiMauro, Matthew J Fell, Santhosh Neelamkavil, Harold B Wood, Peter H Fuller, J Michael Ellis
Discovery and Optimization of Potent, Selective, and Brain-Penetrant 1-Heteroaryl-1 H -Indazole LRRK2 Kinase Inhibitors for the Treatment of Parkinson's Disease. Journal of medicinal chemistry (2022)
Min Lu, Hongjun Zhang, Derun Li, Matthew Childers, Qinglin Pu, Rachel L Palte, Symon Gathiaka, Thomas W Lyons, Anandan Palani, Peter W Fan, Peter Spacciapoli, J Richard Miller, Hyelim Cho, Mangeng Cheng, Kalyan Chakravarthy, Jennifer O'Neil, Padmanabhan Eangoor, Adam Beard, Hai-Young Kim, Josep Saurí, Hakan Gunaydin, David L Sloman, Phieng Siliphaivanh, Jared Cumming, Christian Fischer
Structure-Based Discovery of Proline-Derived Arginase Inhibitors with Improved Oral Bioavailability for Immuno-Oncology. ACS medicinal chemistry letters 12 (9) (2021)