Gerrit J Poelarends

Publication Activity (10 Years)

Years Active: 2016-2024
Publications (10 Years): 41

Top Topics

Structural Basis

Gas Chromatography Mass Spectrometry

Histone Deacetylase

Top Venues

Chembiochem : a European journal of chemical biology

Journal of medicinal chemistry

Organic & biomolecular chemistry

Angewandte Chemie (International ed. in English)

This page only lists publications with an associated author ORCID identifier.

Publications

Chunlong Zhao, Jianqiu Zhang, Hangyu Zhou, Rita Setroikromo, Gerrit J Poelarends, Frank J Dekker
Exploration of Hydrazide-Based HDAC8 PROTACs for the Treatment of Hematological Malignancies and Solid Tumors. Journal of medicinal chemistry 67 (16) (2024)
Sara Russo, Alejandro Prats Luján, Marco W Fraaije, Gerrit J Poelarends
Synthesis of Pharmaceutically Relevant Arylamines Enabled by a Nitroreductase from Bacillus tequilensis. Chembiochem : a European journal of chemical biology 25 (10) (2024)
Sara Russo, Alejandro Prats Luján, Marco W Fraaije, Gerrit J Poelarends
Synthesis of Pharmaceutically Relevant Arylamines Enabled by a Nitroreductase from Bacillus tequilensis. Chembiochem : a European journal of chemical biology (2024)
Chunlong Zhao, Jianqiu Zhang, Hangyu Zhou, Rita Setroikromo, Gerrit J Poelarends, Frank J Dekker
Exploration of Hydrazide-Based HDAC8 PROTACs for the Treatment of Hematological Malignancies and Solid Tumors. Journal of medicinal chemistry 67 (16) (2024)
Mohammad Faizan Bhat, Alejandro Prats Luján, Mohammad Saifuddin, Peter Fodran, Gerrit J Poelarends
Multigram-scale chemoenzymatic synthesis of diverse aminopolycarboxylic acids as potential metallo-β-lactamase inhibitors. Organic & biomolecular chemistry 22 (3) (2024)
Mohammad Faizan Bhat, Alejandro Prats Luján, Mohammad Saifuddin, Peter Fodran, Gerrit J Poelarends
Multigram-scale chemoenzymatic synthesis of diverse aminopolycarboxylic acids as potential metallo-β-lactamase inhibitors. Organic & biomolecular chemistry 22 (3) (2024)
Chunlong Zhao, Jianqiu Zhang, Hangyu Zhou, Rita Setroikromo, Gerrit J Poelarends, Frank J Dekker
Exploration of Hydrazide-Based HDAC8 PROTACs for the Treatment of Hematological Malignancies and Solid Tumors. Journal of medicinal chemistry (2024)
Chunlong Zhao, Jianqiu Zhang, Hangyu Zhou, Rita Setroikromo, Gerrit J Poelarends, Frank J Dekker
Exploration of Hydrazide-Based HDAC8 PROTACs for the Treatment of Hematological Malignancies and Solid Tumors. Journal of medicinal chemistry 67 (16) (2024)
Mohammad Faizan Bhat, Alejandro Prats Luján, Mohammad Saifuddin, Peter Fodran, Gerrit J Poelarends
Multigram-scale chemoenzymatic synthesis of diverse aminopolycarboxylic acids as potential metallo-β-lactamase inhibitors. Organic & biomolecular chemistry 22 (3) (2024)
Mohammad Faizan Bhat, Alejandro Prats Luján, Mohammad Saifuddin, Peter Fodran, Gerrit J Poelarends
Multigram-scale chemoenzymatic synthesis of diverse aminopolycarboxylic acids as potential metallo-β-lactamase inhibitors. Organic & biomolecular chemistry 22 (3) (2024)
Vasilis Tseliou, Laura Kqiku, Martin Berger, Florian Schiel, Hangyu Zhou, Gerrit J Poelarends, Paolo Melchiorre
Stereospecific radical coupling with a non-natural photodecarboxylase. Nature (2024)
Mohammad Faizan Bhat, Alejandro Prats Luján, Mohammad Saifuddin, Peter Fodran, Gerrit J Poelarends
Multigram-scale chemoenzymatic synthesis of diverse aminopolycarboxylic acids as potential metallo-β-lactamase inhibitors. Organic & biomolecular chemistry (2023)
Deng Chen, Angelina Osipyan, Jeaunice Adriana, Mohammed Kader, Maxim A Gureev, Catharina W J Knol, Marie-Cathérine Sigmund, Zhangping Xiao, Petra E van der Wouden, Robbert H Cool, Gerrit J Poelarends, Frank J Dekker
Allosteric Inhibitors of Macrophage Migration Inhibitory Factor (MIF) Interfere with Apoptosis-Inducing Factor (AIF) Co-Localization to Prevent Parthanatos. Journal of medicinal chemistry (2023)
Alejandro Prats Luján, Mohammad Faizan Bhat, Sona Tsaturyan, Ronald van Merkerk, Haigen Fu, Gerrit J Poelarends
Tailored photoenzymatic systems for selective reduction of aliphatic and aromatic nitro compounds fueled by light. Nature communications 14 (1) (2023)
Guangcai Xu, Gerrit J Poelarends
Unlocking New Reactivities in Enzymes by Iminium Catalysis. Angewandte Chemie (International ed. in English) 61 (30) (2022)
Shanshan Song, Zhangping Xiao, Frank J Dekker, Gerrit J Poelarends, Barbro N Melgert
Macrophage migration inhibitory factor family proteins are multitasking cytokines in tissue injury. Cellular and molecular life sciences : CMLS 79 (2) (2022)
Marie-Cathérine Sigmund, Guangcai Xu, Eleonora Grandi, Gerrit J Poelarends
Enhancing the Peroxygenase Activity of a Cofactor-Independent Peroxyzyme by Directed Evolution Enabling Gram-Scale Epoxide Synthesis. Chemistry (Weinheim an der Bergstrasse, Germany) 28 (59) (2022)
Andreas Kunzendorf, Mohammad Saifuddin, Gerrit J Poelarends
Enantiocomplementary Michael Additions of Acetaldehyde to Aliphatic Nitroalkenes Catalyzed by Proline-Based Carboligases. Chembiochem : a European journal of chemical biology 23 (6) (2022)
Mohammad Z Abidin, Thangavelu Saravanan, Laura Bothof, Pieter G Tepper, Andy-Mark W H Thunnissen, Gerrit J Poelarends
Biocatalytic enantioselective hydroaminations enabling synthesis of N-arylalkyl-substituted L-aspartic acids. Organic & biomolecular chemistry 19 (29) (2022)
Mohammad Faizan Bhat, Alejandro Prats Luján, Mohammad Saifuddin, Gerrit J Poelarends
Chemoenzymatic Asymmetric Synthesis of Complex Heterocycles: Dihydrobenzoxazinones and Dihydroquinoxalinones. ACS catalysis 12 (18) (2022)
Zhangping Xiao, Angelina Osipyan, Shanshan Song, Deng Chen, Reinder A Schut, Ronald van Merkerk, Petra E van der Wouden, Robbert H Cool, Wim J Quax, Barbro N Melgert, Gerrit J Poelarends, Frank J Dekker
Thieno[2,3- d ]pyrimidine-2,4(1 H ,3 H )-dione Derivative Inhibits d-Dopachrome Tautomerase Activity and Suppresses the Proliferation of Non-Small Cell Lung Cancer Cells. Journal of medicinal chemistry 65 (3) (2022)
Mohammad Z Abidin, Thangavelu Saravanan, Erick Strauss, Gerrit J Poelarends
The broad amine scope of pantothenate synthetase enables the synthesis of pharmaceutically relevant amides. Organic & biomolecular chemistry 19 (20) (2022)
Andreas Kunzendorf, Guangcai Xu, Mohammad Saifuddin, Thangavelu Saravanan, Gerrit J Poelarends
Biocatalytic Asymmetric Cyclopropanations via Enzyme-Bound Iminium Ion Intermediates. Angewandte Chemie (International ed. in English) 60 (45) (2021)
Andreas Kunzendorf, Guangcai Xu, Jesse J H van der Velde, Henriëtte J Rozeboom, Andy-Mark W H Thunnissen, Gerrit J Poelarends
Unlocking Asymmetric Michael Additions in an Archetypical Class I Aldolase by Directed Evolution. ACS catalysis 11 (21) (2021)
Zhangping Xiao, Shanshan Song, Deng Chen, Ronald van Merkerk, Petra E van der Wouden, Robbert H Cool, Wim J Quax, Gerrit J Poelarends, Barbro N Melgert, Frank J Dekker
Proteolysis Targeting Chimera (PROTAC) for Macrophage Migration Inhibitory Factor (MIF) Has Anti-Proliferative Activity in Lung Cancer Cells. Angewandte Chemie (International ed. in English) 60 (32) (2021)
Valentina Arkhipova, Haigen Fu, Mark W H Hoorens, Gianluca Trinco, Lucien N Lameijer, Egor Marin, Ben L Feringa, Gerrit J Poelarends, Wiktor Szymanski, Dirk J Slotboom, Albert Guskov
Structural Aspects of Photopharmacology: Insight into the Binding of Photoswitchable and Photocaged Inhibitors to the Glutamate Transporter Homologue. Journal of the American Chemical Society 143 (3) (2021)
Chao Guo, Yan Ni, Lieuwe Biewenga, Tjaard Pijning, Andy-Mark W H Thunnissen, Gerrit J Poelarends
Using Mutability Landscapes To Guide Enzyme Thermostabilization. Chembiochem : a European journal of chemical biology 22 (1) (2020)
Jielin Zhang, Mohammad Z Abidin, Thangavelu Saravanan, Gerrit J Poelarends
Recent Applications of Carbon-Nitrogen Lyases in Asymmetric Synthesis of Noncanonical Amino Acids and Heterocyclic Compounds. Chembiochem : a European journal of chemical biology 21 (19) (2020)
Kamaleddin H M E Tehrani, Haigen Fu, Nora C Brüchle, Vida Mashayekhi, Alejandro Prats Luján, Matthijs J van Haren, Gerrit J Poelarends, Nathaniel I Martin
Aminocarboxylic acids related to aspergillomarasmine A (AMA) and ethylenediamine-N,N'-disuccinic acid (EDDS) are strong zinc-binders and inhibitors of the metallo-beta-lactamase NDM-1. Chemical communications (Cambridge, England) 56 (20) (2020)
Zhangping Xiao, Deng Chen, Shanshan Song, Ramon van der Vlag, Petra E van der Wouden, Ronald van Merkerk, Robbert H Cool, Anna Katharina Herta Hirsch, Barbro N Melgert, Wim J Quax, Gerrit J Poelarends, Frank J Dekker
7-Hydroxycoumarins Are Affinity-Based Fluorescent Probes for Competitive Binding Studies of Macrophage Migration Inhibitory Factor. Journal of medicinal chemistry 63 (20) (2020)
Chao Guo, Lieuwe Biewenga, Max Lubberink, Ronald van Merkerk, Gerrit J Poelarends
Tuning Enzyme Activity for Nonaqueous Solvents: Engineering an Enantioselective "Michaelase" for Catalysis in High Concentrations of Ethanol. Chembiochem : a European journal of chemical biology 21 (10) (2020)
Lieuwe Biewenga, Andreas Kunzendorf, Gerrit J Poelarends
In Situ Acetaldehyde Synthesis for Carboligation Reactions. Chembiochem : a European journal of chemical biology 21 (10) (2020)
Guangcai Xu, Michele Crotti, Thangavelu Saravanan, Kim M Kataja, Gerrit J Poelarends
Enantiocomplementary Epoxidation Reactions Catalyzed by an Engineered Cofactor-Independent Non-natural Peroxygenase. Angewandte Chemie (International ed. in English) 59 (26) (2020)
Jielin Zhang, Eleonora Grandi, Haigen Fu, Thangavelu Saravanan, Laura Bothof, Pieter G Tepper, Andy-Mark W H Thunnissen, Gerrit J Poelarends
Engineered C-N Lyase: Enantioselective Synthesis of Chiral Synthons for Artificial Dipeptide Sweeteners. Angewandte Chemie (International ed. in English) 59 (1) (2019)
Mohammad Z Abidin, Thangavelu Saravanan, Jielin Zhang, Pieter G Tepper, Erick Strauss, Gerrit J Poelarends
Modular Enzymatic Cascade Synthesis of Vitamin B5 and Its Derivatives. Chemistry (Weinheim an der Bergstrasse, Germany) 24 (66) (2018)
Haigen Fu, Jielin Zhang, Pieter G Tepper, Lennart Bunch, Anders A Jensen, Gerrit J Poelarends
Chemoenzymatic Synthesis and Pharmacological Characterization of Functionalized Aspartate Analogues As Novel Excitatory Amino Acid Transporter Inhibitors. Journal of medicinal chemistry 61 (17) (2018)
Mehran Rahimi, Edzard M Geertsema, Yufeng Miao, Jan-Ytzen van der Meer, Thea van den Bosch, Pim de Haan, Ellen Zandvoort, Gerrit J Poelarends
Inter- and intramolecular aldol reactions promiscuously catalyzed by a proline-based tautomerase. Organic & biomolecular chemistry 15 (13) (2018)
Harshwardhan Poddar, Jandré de Villiers, Jielin Zhang, Vinod Puthan Veetil, Hans Raj, Andy-Mark W H Thunnissen, Gerrit J Poelarends
Structural Basis for the Catalytic Mechanism of Ethylenediamine- N, N'-disuccinic Acid Lyase, a Carbon-Nitrogen Bond-Forming Enzyme with a Broad Substrate Scope. Biochemistry 57 (26) (2018)
Mehran Rahimi, Jan-Ytzen van der Meer, Edzard M Geertsema, Gerrit J Poelarends
Engineering a Promiscuous Tautomerase into a More Efficient Aldolase for Self-Condensations of Linear Aliphatic Aldehydes. Chembiochem : a European journal of chemical biology 18 (14) (2017)
Yufeng Miao, Pieter G Tepper, Edzard M Geertsema, Gerrit J Poelarends
Stereochemical Control of Enzymatic Carbon-Carbon Bond-Forming Michael-Type Additions by "Substrate Engineering". European journal of organic chemistry 2016 (32) (2016)
Mehran Rahimi, Jan-Ytzen van der Meer, Edzard M Geertsema, Harshwardhan Poddar, Bert-Jan Baas, Gerrit J Poelarends
Mutations Closer to the Active Site Improve the Promiscuous Aldolase Activity of 4-Oxalocrotonate Tautomerase More Effectively than Distant Mutations. Chembiochem : a European journal of chemical biology 17 (13) (2016)