Nathaniel I Martin

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 94

Top Topics

Histone Deacetylase

Multidrug Resistant

Staphylococcus Aureus

Top Venues

ACS infectious diseases

Journal of the American Chemical Society

Chemical science

This page only lists publications with an associated author ORCID identifier.

Publications

Cornelis J Slingerland, Nathaniel I Martin
Recent Advances in the Development of Polymyxin Antibiotics: 2010-2023. ACS infectious diseases 10 (4) (2024)
Cornelis J Slingerland, Nathaniel I Martin
Recent Advances in the Development of Polymyxin Antibiotics: 2010-2023. ACS infectious diseases 10 (4) (2024)
Valentina Pozzi, Elisa Molinelli, Roberto Campagna, Emma Nicol Serritelli, Monia Cecati, Edoardo De Simoni, Davide Sartini, Gaia Goteri, Nathaniel I Martin, Matthijs J van Haren, Eleonora Salvolini, Oriana Simonetti, Annamaria Offidani, Monica Emanuelli
Knockdown of nicotinamide N-methyltransferase suppresses proliferation, migration, and chemoresistance of Merkel cell carcinoma cells in vitro. Human cell 37 (3) (2024)
Nataliia V Machushynets, Karol Al Ayed, Barbara R Terlouw, Chao Du, Ned P Buijs, Joost Willemse, Somayah S Elsayed, Julian Schill, Vincent Trebosc, Michel Pieren, Francesca M Alexander, Stephen A Cochrane, Mark R Liles, Marnix H Medema, Nathaniel I Martin, Gilles P van Wezel
Discovery and Derivatization of Tridecaptin Antibiotics with Altered Host Specificity and Enhanced Bioactivity. ACS chemical biology 19 (5) (2024)
Shehrazade Jekhmane, Maik G N Derks, Sourav Maity, Cornelis J Slingerland, Kamaleddin H M E Tehrani, Joao Medeiros-Silva, Vicky Charitou, Danique Ammerlaan, Céline Fetz, Naomi A Consoli, Rachel V K Cochrane, Eilidh J Matheson, Mick van der Weijde, Barend O W Elenbaas, Francesca Lavore, Ruud Cox, Joseph Helmuth Lorent, Marc Baldus, Markus Künzler, Moreno Lelli, Stephen A Cochrane, Nathaniel I Martin, Wouter H Roos, Eefjan Breukink, Markus H Weingarth
Host defence peptide plectasin targets bacterial cell wall precursor lipid II by a calcium-sensitive supramolecular mechanism. Nature microbiology 9 (7) (2024)
Ned P Buijs, Halana C Vlaming, Ioli Kotsogianni, Melina Arts, Joost J Willemse, Yunhao Duan, Francesca M Alexander, Stephen A Cochrane, Tanja Schneider, Nathaniel I Martin
A classic antibiotic reimagined: Rationally designed bacitracin variants exhibit potent activity against vancomycin-resistant pathogens. Proceedings of the National Academy of Sciences of the United States of America 121 (29) (2024)
Kevin Christopher Ludwig, Jan-Samuel Puls, Cruz L Matos de Opitz, Paolo Innocenti, Jan-Martin Daniel, Jan Bornikoel, Melina Arts, Sebastian Krannich, Jan Straetener, Dominik Brajtenbach, Beate Henrichfreise, Peter Sass, Anna Mueller, Nathaniel I Martin, Heike Brötz-Oesterhelt, Ulrich Kubitscheck, Fabian Grein, Tanja Schneider
The Dual Mode of Antibacterial Action of the Synthetic Small Molecule DCAP Involves Lipid II Binding. Journal of the American Chemical Society (2024)
Nataliia V Machushynets, Karol Al Ayed, Barbara R Terlouw, Chao Du, Ned P Buijs, Joost Willemse, Somayah S Elsayed, Julian Schill, Vincent Trebosc, Michel Pieren, Francesca M Alexander, Stephen A Cochrane, Mark R Liles, Marnix H Medema, Nathaniel I Martin, Gilles P van Wezel
Discovery and Derivatization of Tridecaptin Antibiotics with Altered Host Specificity and Enhanced Bioactivity. ACS chemical biology (2024)
Cornelis J Slingerland, Nathaniel I Martin
Recent Advances in the Development of Polymyxin Antibiotics: 2010-2023. ACS infectious diseases 10 (4) (2024)
Nataliia V Machushynets, Karol Al Ayed, Barbara R Terlouw, Chao Du, Ned P Buijs, Joost Willemse, Somayah S Elsayed, Julian Schill, Vincent Trebosc, Michel Pieren, Francesca M Alexander, Stephen A Cochrane, Mark R Liles, Marnix H Medema, Nathaniel I Martin, Gilles P van Wezel
Discovery and Derivatization of Tridecaptin Antibiotics with Altered Host Specificity and Enhanced Bioactivity. ACS chemical biology 19 (5) (2024)
Emma van Groesen, Elma Mons, Ioli Kotsogianni, Melina Arts, Kamaleddin H M E Tehrani, Nicola Wade, Vladyslav Lysenko, Florence M Stel, Jordy T Zwerus, Stefania De Benedetti, Alexander Bakker, Parichita Chakraborty, Mario van der Stelt, Dirk-Jan Scheffers, Jairo Gooskens, Wiep Klaas Smits, Kirsty Holden, Peter S Gilmour, Joost J Willemse, Christopher A Hitchcock, Johan G C van Hasselt, Tanja Schneider, Nathaniel I Martin
Semisynthetic guanidino lipoglycopeptides with potent in vitro and in vivo antibacterial activity. Science translational medicine 16 (759) (2024)
Cornelis J Slingerland, Nathaniel I Martin
Recent Advances in the Development of Polymyxin Antibiotics: 2010-2023. ACS infectious diseases 10 (4) (2024)
Valentina Pozzi, Elisa Molinelli, Roberto Campagna, Emma Nicol Serritelli, Monia Cecati, Edoardo De Simoni, Davide Sartini, Gaia Goteri, Nathaniel I Martin, Matthijs J van Haren, Eleonora Salvolini, Oriana Simonetti, Annamaria Offidani, Monica Emanuelli
Knockdown of nicotinamide N-methyltransferase suppresses proliferation, migration, and chemoresistance of Merkel cell carcinoma cells in vitro. Human cell (2024)
Ned P Buijs, Halana C Vlaming, Ioli Kotsogianni, Melina Arts, Joost J Willemse, Yunhao Duan, Francesca M Alexander, Stephen A Cochrane, Tanja Schneider, Nathaniel I Martin
A classic antibiotic reimagined: Rationally designed bacitracin variants exhibit potent activity against vancomycin-resistant pathogens. Proceedings of the National Academy of Sciences of the United States of America 121 (29) (2024)
Valentina Pozzi, Elisa Molinelli, Roberto Campagna, Emma Nicol Serritelli, Monia Cecati, Edoardo De Simoni, Davide Sartini, Gaia Goteri, Nathaniel I Martin, Matthijs J van Haren, Eleonora Salvolini, Oriana Simonetti, Annamaria Offidani, Monica Emanuelli
Knockdown of nicotinamide N-methyltransferase suppresses proliferation, migration, and chemoresistance of Merkel cell carcinoma cells in vitro. Human cell 37 (3) (2024)
Alexander T Bakker, Ioli Kotsogianni, Mariana Avalos, Jeroen M Punt, Bing Liu, Diana Piermarini, Berend Gagestein, Cornelis J Slingerland, Le Zhang, Joost J Willemse, Leela B Ghimire, Richard J H B N van den Berg, Antonius P A Janssen, Tom H M Ottenhoff, Constant A A van Boeckel, Gilles P van Wezel, Dmitry Ghilarov, Nathaniel I Martin, Mario van der Stelt
Discovery of isoquinoline sulfonamides as allosteric gyrase inhibitors with activity against fluoroquinolone-resistant bacteria. Nature chemistry (2024)
Cornelis J Slingerland, Nathaniel I Martin
Recent Advances in the Development of Polymyxin Antibiotics: 2010-2023. ACS infectious diseases (2024)
Cornelis J Slingerland, Nathaniel I Martin
Recent Advances in the Development of Polymyxin Antibiotics: 2010-2023. ACS infectious diseases 10 (4) (2024)
Shehrazade Jekhmane, Maik G N Derks, Sourav Maity, Cornelis J Slingerland, Kamaleddin H M E Tehrani, Joao Medeiros-Silva, Vicky Charitou, Danique Ammerlaan, Céline Fetz, Naomi A Consoli, Rachel V K Cochrane, Eilidh J Matheson, Mick van der Weijde, Barend O W Elenbaas, Francesca Lavore, Ruud Cox, Joseph Helmuth Lorent, Marc Baldus, Markus Künzler, Moreno Lelli, Stephen A Cochrane, Nathaniel I Martin, Wouter H Roos, Eefjan Breukink, Markus H Weingarth
Host defence peptide plectasin targets bacterial cell wall precursor lipid II by a calcium-sensitive supramolecular mechanism. Nature microbiology 9 (7) (2024)
Shehrazade Jekhmane, Maik G N Derks, Sourav Maity, Cornelis J Slingerland, Kamaleddin H M E Tehrani, Joao Medeiros-Silva, Vicky Charitou, Danique Ammerlaan, Céline Fetz, Naomi A Consoli, Rachel V K Cochrane, Eilidh J Matheson, Mick van der Weijde, Barend O W Elenbaas, Francesca Lavore, Ruud Cox, Joseph Helmuth Lorent, Marc Baldus, Markus Künzler, Moreno Lelli, Stephen A Cochrane, Nathaniel I Martin, Wouter H Roos, Eefjan Breukink, Markus H Weingarth
Host defence peptide plectasin targets bacterial cell wall precursor lipid II by a calcium-sensitive supramolecular mechanism. Nature microbiology (2024)
Emma van Groesen, Elma Mons, Ioli Kotsogianni, Melina Arts, Kamaleddin H M E Tehrani, Nicola Wade, Vladyslav Lysenko, Florence M Stel, Jordy T Zwerus, Stefania De Benedetti, Alexander Bakker, Parichita Chakraborty, Mario van der Stelt, Dirk-Jan Scheffers, Jairo Gooskens, Wiep Klaas Smits, Kirsty Holden, Peter S Gilmour, Joost J Willemse, Christopher A Hitchcock, Johan G C van Hasselt, Tanja Schneider, Nathaniel I Martin
Semisynthetic guanidino lipoglycopeptides with potent in vitro and in vivo antibacterial activity. Science translational medicine 16 (759) (2024)
Ned P Buijs, Halana C Vlaming, Ioli Kotsogianni, Melina Arts, Joost J Willemse, Yunhao Duan, Francesca M Alexander, Stephen A Cochrane, Tanja Schneider, Nathaniel I Martin
A classic antibiotic reimagined: Rationally designed bacitracin variants exhibit potent activity against vancomycin-resistant pathogens. Proceedings of the National Academy of Sciences of the United States of America 121 (29) (2024)
Nataliia V Machushynets, Karol Al Ayed, Barbara R Terlouw, Chao Du, Ned P Buijs, Joost Willemse, Somayah S Elsayed, Julian Schill, Vincent Trebosc, Michel Pieren, Francesca M Alexander, Stephen A Cochrane, Mark R Liles, Marnix H Medema, Nathaniel I Martin, Gilles P van Wezel
Discovery and Derivatization of Tridecaptin Antibiotics with Altered Host Specificity and Enhanced Bioactivity. ACS chemical biology 19 (5) (2024)
Cornelis J Slingerland, Nathaniel I Martin
Recent Advances in the Development of Polymyxin Antibiotics: 2010-2023. ACS infectious diseases 10 (4) (2024)
Valentina Pozzi, Elisa Molinelli, Roberto Campagna, Emma Nicol Serritelli, Monia Cecati, Edoardo De Simoni, Davide Sartini, Gaia Goteri, Nathaniel I Martin, Matthijs J van Haren, Eleonora Salvolini, Oriana Simonetti, Annamaria Offidani, Monica Emanuelli
Knockdown of nicotinamide N-methyltransferase suppresses proliferation, migration, and chemoresistance of Merkel cell carcinoma cells in vitro. Human cell 37 (3) (2024)
Shehrazade Jekhmane, Maik G N Derks, Sourav Maity, Cornelis J Slingerland, Kamaleddin H M E Tehrani, Joao Medeiros-Silva, Vicky Charitou, Danique Ammerlaan, Céline Fetz, Naomi A Consoli, Rachel V K Cochrane, Eilidh J Matheson, Mick van der Weijde, Barend O W Elenbaas, Francesca Lavore, Ruud Cox, Joseph Helmuth Lorent, Marc Baldus, Markus Künzler, Moreno Lelli, Stephen A Cochrane, Nathaniel I Martin, Wouter H Roos, Eefjan Breukink, Markus H Weingarth
Host defence peptide plectasin targets bacterial cell wall precursor lipid II by a calcium-sensitive supramolecular mechanism. Nature microbiology 9 (7) (2024)
Valentina Pozzi, Elisa Molinelli, Roberto Campagna, Emma Nicol Serritelli, Monia Cecati, Edoardo De Simoni, Davide Sartini, Gaia Goteri, Nathaniel I Martin, Matthijs J van Haren, Eleonora Salvolini, Oriana Simonetti, Annamaria Offidani, Monica Emanuelli
Knockdown of nicotinamide N-methyltransferase suppresses proliferation, migration, and chemoresistance of Merkel cell carcinoma cells in vitro. Human cell 37 (3) (2024)
Nataliia V Machushynets, Karol Al Ayed, Barbara R Terlouw, Chao Du, Ned P Buijs, Joost Willemse, Somayah S Elsayed, Julian Schill, Vincent Trebosc, Michel Pieren, Francesca M Alexander, Stephen A Cochrane, Mark R Liles, Marnix H Medema, Nathaniel I Martin, Gilles P van Wezel
Discovery and Derivatization of Tridecaptin Antibiotics with Altered Host Specificity and Enhanced Bioactivity. ACS chemical biology 19 (5) (2024)
Valentina Pozzi, Elisa Molinelli, Roberto Campagna, Emma Nicol Serritelli, Monia Cecati, Edoardo De Simoni, Davide Sartini, Gaia Goteri, Nathaniel I Martin, Matthijs J van Haren, Eleonora Salvolini, Oriana Simonetti, Annamaria Offidani, Monica Emanuelli
Knockdown of nicotinamide N-methyltransferase suppresses proliferation, migration, and chemoresistance of Merkel cell carcinoma cells in vitro. Human cell 37 (3) (2024)
Valentina Pozzi, Elisa Molinelli, Roberto Campagna, Emma Nicol Serritelli, Monia Cecati, Edoardo De Simoni, Davide Sartini, Gaia Goteri, Nathaniel I Martin, Matthijs J van Haren, Eleonora Salvolini, Oriana Simonetti, Annamaria Offidani, Monica Emanuelli
Knockdown of nicotinamide N-methyltransferase suppresses proliferation, migration, and chemoresistance of Merkel cell carcinoma cells in vitro. Human cell 37 (3) (2024)
Valentina Pozzi, Elisa Molinelli, Roberto Campagna, Emma Nicol Serritelli, Monia Cecati, Edoardo De Simoni, Davide Sartini, Gaia Goteri, Nathaniel I Martin, Matthijs J van Haren, Eleonora Salvolini, Oriana Simonetti, Annamaria Offidani, Monica Emanuelli
Knockdown of nicotinamide N-methyltransferase suppresses proliferation, migration, and chemoresistance of Merkel cell carcinoma cells in vitro. Human cell 37 (3) (2024)
Mei-Ling Gao, Ioli Kotsogianni, Foteini Skoulikopoulou, Nora C Brüchle, Paolo Innocenti, Nathaniel I Martin
Synthesis and Evaluation of Carbapenem/Metallo-β-Lactamase Inhibitor Conjugates. ChemMedChem (2024)
Nataliia V Machushynets, Karol Al Ayed, Barbara R Terlouw, Chao Du, Ned P Buijs, Joost Willemse, Somayah S Elsayed, Julian Schill, Vincent Trebosc, Michel Pieren, Francesca M Alexander, Stephen A Cochrane, Mark R Liles, Marnix H Medema, Nathaniel I Martin, Gilles P van Wezel
Discovery and Derivatization of Tridecaptin Antibiotics with Altered Host Specificity and Enhanced Bioactivity. ACS chemical biology 19 (5) (2024)
Shehrazade Jekhmane, Maik G N Derks, Sourav Maity, Cornelis J Slingerland, Kamaleddin H M E Tehrani, Joao Medeiros-Silva, Vicky Charitou, Danique Ammerlaan, Céline Fetz, Naomi A Consoli, Rachel V K Cochrane, Eilidh J Matheson, Mick van der Weijde, Barend O W Elenbaas, Francesca Lavore, Ruud Cox, Joseph Helmuth Lorent, Marc Baldus, Markus Künzler, Moreno Lelli, Stephen A Cochrane, Nathaniel I Martin, Wouter H Roos, Eefjan Breukink, Markus H Weingarth
Host defence peptide plectasin targets bacterial cell wall precursor lipid II by a calcium-sensitive supramolecular mechanism. Nature microbiology 9 (7) (2024)
Shehrazade Jekhmane, Maik G N Derks, Sourav Maity, Cornelis J Slingerland, Kamaleddin H M E Tehrani, Joao Medeiros-Silva, Vicky Charitou, Danique Ammerlaan, Céline Fetz, Naomi A Consoli, Rachel V K Cochrane, Eilidh J Matheson, Mick van der Weijde, Barend O W Elenbaas, Francesca Lavore, Ruud Cox, Joseph Helmuth Lorent, Marc Baldus, Markus Künzler, Moreno Lelli, Stephen A Cochrane, Nathaniel I Martin, Wouter H Roos, Eefjan Breukink, Markus H Weingarth
Host defence peptide plectasin targets bacterial cell wall precursor lipid II by a calcium-sensitive supramolecular mechanism. Nature microbiology 9 (7) (2024)
Ali Javed, Cornelis J Slingerland, Thomas M Wood, Nathaniel I Martin, Femke Broere, Markus H Weingarth, Edwin J A Veldhuizen
Chimeric Peptidomimetic Antibiotic Efficiently Neutralizes Lipopolysaccharides (LPS) and Bacteria-Induced Activation of RAW Macrophages. ACS infectious diseases 9 (3) (2023)
Ali Javed, Cornelis J Slingerland, Thomas M Wood, Nathaniel I Martin, Femke Broere, Markus H Weingarth, Edwin J A Veldhuizen
Chimeric Peptidomimetic Antibiotic Efficiently Neutralizes Lipopolysaccharides (LPS) and Bacteria-Induced Activation of RAW Macrophages. ACS infectious diseases (2023)
Ned P Buijs, Eilidh J Matheson, Stephen A Cochrane, Nathaniel I Martin
Targeting membrane-bound bacterial cell wall precursors: a tried and true antibiotic strategy in nature and the clinic. Chemical communications (Cambridge, England) (2023)
Ali Javed, Cornelis J Slingerland, Thomas M Wood, Nathaniel I Martin, Femke Broere, Markus H Weingarth, Edwin J A Veldhuizen
Chimeric Peptidomimetic Antibiotic Efficiently Neutralizes Lipopolysaccharides (LPS) and Bacteria-Induced Activation of RAW Macrophages. ACS infectious diseases 9 (3) (2023)
Ali Javed, Cornelis J Slingerland, Thomas M Wood, Nathaniel I Martin, Femke Broere, Markus H Weingarth, Edwin J A Veldhuizen
Chimeric Peptidomimetic Antibiotic Efficiently Neutralizes Lipopolysaccharides (LPS) and Bacteria-Induced Activation of RAW Macrophages. ACS infectious diseases 9 (3) (2023)
Michael W Mullowney, Katherine R Duncan, Somayah S Elsayed, Neha Garg, Justin Johan Jozias van der Hooft, Nathaniel I Martin, David Meijer, Barbara R Terlouw, Friederike Biermann, Kai Blin, Janani Durairaj, Marina Gorostiola González, Eric J N Helfrich, Florian Huber, Stefan Leopold-Messer, Kohulan Rajan, Tristan de Rond, Jeffrey A van Santen, Maria Sorokina, Marcy J Balunas, Mehdi A Beniddir, Doris A van Bergeijk, Laura M Carroll, Chase M Clark, Djork-Arné Clevert, Chris A Dejong, Chao Du, Scarlet Ferrinho, Francesca Grisoni, Albert Hofstetter, Willem Jespers, Olga V Kalinina, Satria A Kautsar, Hyun Woo Kim, Tiago F Leao, Joleen Masschelein, Evan R Rees, Raphael Reher, Daniel Reker, Philippe Schwaller, Marwin Segler, Michael A Skinnider, Allison S Walker, Egon L Wilighagen, Barbara Zdrazil, Nadine Ziemert, Rebecca J M Goss, Pierre Guyomard, Andrea Volkamer, William H Gerwick, Hyun Uk Kim, Daniel Krug, Gilles P van Wezel, Gerard van Westen, Anna Katharina Herta Hirsch, Roger G Linington, Serina L Robinson, Marnix H Medema
Artificial intelligence for natural product drug discovery. Nature reviews. Drug discovery (2023)
Ali Javed, Cornelis J Slingerland, Thomas M Wood, Nathaniel I Martin, Femke Broere, Markus H Weingarth, Edwin J A Veldhuizen
Chimeric Peptidomimetic Antibiotic Efficiently Neutralizes Lipopolysaccharides (LPS) and Bacteria-Induced Activation of RAW Macrophages. ACS infectious diseases 9 (3) (2023)
Jinhyuk Bhin, Julia Yemelyanenko, Xue Chao, Sjoerd Klarenbeek, Mark Opdam, Yuval Malka, Liesbeth Hoekman, Dinja T Kruger, Onno B Bleijerveld, Chiara S Brambillasca, Justin Sprengers, Bjorn Siteur, Stefano Annunziato, Matthijs J van Haren, Nathaniel I Martin, Marieke van de Ven, Dennis Peters, Reuven Agami, Sabine C Linn, Epie Boven, A F Maarten Altelaar, Jos Jonkers, Daniel Zingg, Lodewyk F A Wessels
MYC is a clinically significant driver of mTOR inhibitor resistance in breast cancer. The Journal of experimental medicine 220 (11) (2023)
Karol Al Ayed, Denise Zamarbide Losada, Nataliia V Machushynets, Barbara Terlouw, Somayah S Elsayed, Julian Schill, Vincent Trebosc, Michel Pieren, Marnix H Medema, Gilles P van Wezel, Nathaniel I Martin
Total Synthesis and Structure Assignment of the Relacidine Lipopeptide Antibiotics and Preparation of Analogues with Enhanced Stability. ACS infectious diseases (2023)
Matthias Fellner, Annabel Walsh, Stephen Dela Ahator, Nadia Aftab, Ben Sutherland, Eng W Tan, Alexander T Bakker, Nathaniel I Martin, Mario van der Stelt, Christian S Lentz
Biochemical and Cellular Characterization of the Function of Fluorophosphonate-Binding Hydrolase H (FphH) in Staphylococcus aureus Support a Role in Bacterial Stress Response. ACS infectious diseases (2023)
Eduard O Bobylev, Renzo A Knol, Simon Mathew, David A Poole, Ioli Kotsogianni, Nathaniel I Martin, Bas de Bruin, Alexander Kros, Joost N H Reek
In vivo biodistribution of kinetically stable Pt 2 L 4 nanospheres that show anti-cancer activity. Chemical science 14 (25) (2023)
Eduard O Bobylev, Renzo A Knol, Simon Mathew, David A Poole, Ioli Kotsogianni, Nathaniel I Martin, Bas de Bruin, Alexander Kros, Joost N H Reek
In vivo biodistribution of kinetically stable Pt 2 L 4 nanospheres that show anti-cancer activity. Chemical science 14 (25) (2023)
Cornelis J Slingerland, Vladyslav Lysenko, Samhita Chaudhuri, Charlotte M J Wesseling, Devon Barnes, Rosalinde Masereeuw, Nathaniel I Martin
Semisynthetic polymyxins with potent antibacterial activity and reduced kidney cell toxicity. RSC medicinal chemistry 14 (11) (2023)
Eduard O Bobylev, Renzo A Knol, Simon Mathew, David A Poole, Ioli Kotsogianni, Nathaniel I Martin, Bas de Bruin, Alexander Kros, Joost N H Reek
In vivo biodistribution of kinetically stable Pt 2 L 4 nanospheres that show anti-cancer activity. Chemical science 14 (25) (2023)
Ali Javed, Cornelis J Slingerland, Thomas M Wood, Nathaniel I Martin, Femke Broere, Markus H Weingarth, Edwin J A Veldhuizen
Chimeric Peptidomimetic Antibiotic Efficiently Neutralizes Lipopolysaccharides (LPS) and Bacteria-Induced Activation of RAW Macrophages. ACS infectious diseases (2023)
Ross D Ballantine, Karol Al Ayed, Samantha J Bann, Michael Hoekstra, Nathaniel I Martin, Stephen A Cochrane
Linearization of the Brevicidine and Laterocidine Lipopeptides Yields Analogues That Retain Full Antibacterial Activity. Journal of medicinal chemistry (2023)
Ned P Buijs, Halana C Vlaming, Matthijs J van Haren, Nathaniel I Martin
Synthetic Studies with Bacitracin A and Preparation of Analogues Containing Alternative Zinc Binding Groups. Chembiochem : a European journal of chemical biology (2022)
Nicola Wade, Charlotte M J Wesseling, Paolo Innocenti, Cornelis J Slingerland, Gregory M Koningstein, Joen Luirink, Nathaniel I Martin
Synthesis and Structure-Activity Studies of β-Barrel Assembly Machine Complex Inhibitor MRL-494. ACS infectious diseases 8 (11) (2022)
Silvie Hansenová Maňásková, Kamran Nazmi, Wim Van't Hof, Alex van Belkum, Wendy Esmeralda Kaman, Nathaniel I Martin, Enno C I Veerman, Floris J Bikker
Natural and Synthetic Sortase A Substrates Are Processed by Staphylococcus aureus via Different Pathways. Bioconjugate chemistry 33 (4) (2022)
Alexander T Bakker, Ioli Kotsogianni, Liza Mirenda, Verena M Straub, Mariana Avalos, Richard J B H N van den Berg, Bogdan I Florea, Gilles P van Wezel, Antonius P A Janssen, Nathaniel I Martin, Mario van der Stelt
Chemical Proteomics Reveals Antibiotic Targets of Oxadiazolones in MRSA. Journal of the American Chemical Society 145 (2) (2022)
Cornelis J Slingerland, Charlotte M J Wesseling, Paolo Innocenti, Koen G C Westphal, Rosalinde Masereeuw, Nathaniel I Martin
Synthesis and Evaluation of Polymyxins Bearing Reductively Labile Disulfide-Linked Lipids. Journal of medicinal chemistry 65 (23) (2022)
Alexander T Bakker, Ioli Kotsogianni, Liza Mirenda, Verena M Straub, Mariana Avalos, Richard J B H N van den Berg, Bogdan I Florea, Gilles P van Wezel, Antonius P A Janssen, Nathaniel I Martin, Mario van der Stelt
Chemical Proteomics Reveals Antibiotic Targets of Oxadiazolones in MRSA. Journal of the American Chemical Society (2022)
Alexander T Bakker, Ioli Kotsogianni, Liza Mirenda, Verena M Straub, Mariana Avalos, Richard J B H N van den Berg, Bogdan I Florea, Gilles P van Wezel, Antonius P A Janssen, Nathaniel I Martin, Mario van der Stelt
Chemical Proteomics Reveals Antibiotic Targets of Oxadiazolones in MRSA. Journal of the American Chemical Society 145 (2) (2022)
Emma van Groesen, Paolo Innocenti, Nathaniel I Martin
Recent Advances in the Development of Semisynthetic Glycopeptide Antibiotics: 2014-2022. ACS infectious diseases 8 (8) (2022)
Alexander T Bakker, Ioli Kotsogianni, Liza Mirenda, Verena M Straub, Mariana Avalos, Richard J B H N van den Berg, Bogdan I Florea, Gilles P van Wezel, Antonius P A Janssen, Nathaniel I Martin, Mario van der Stelt
Chemical Proteomics Reveals Antibiotic Targets of Oxadiazolones in MRSA. Journal of the American Chemical Society 145 (2) (2022)
Roderick Corstiaan Abraham Versloot, Florian Leonardus Rudolfus Lucas, Liubov Yakovlieva, Matthijs Jonathan Tadema, Yurui Zhang, Thomas M Wood, Nathaniel I Martin, Siewert-Jan Marrink, Marthe T C Walvoort, Giovanni Maglia
Quantification of Protein Glycosylation Using Nanopores. Nano letters 22 (13) (2022)
Alexander T Bakker, Ioli Kotsogianni, Liza Mirenda, Verena M Straub, Mariana Avalos, Richard J B H N van den Berg, Bogdan I Florea, Gilles P van Wezel, Antonius P A Janssen, Nathaniel I Martin, Mario van der Stelt
Chemical Proteomics Reveals Antibiotic Targets of Oxadiazolones in MRSA. Journal of the American Chemical Society 145 (2) (2022)
Charlotte M J Wesseling, Nathaniel I Martin
Synergy by Perturbing the Gram-Negative Outer Membrane: Opening the Door for Gram-Positive Specific Antibiotics. ACS infectious diseases 8 (9) (2022)
Thomas M Wood, Matthieu R Zeronian, Ned Buijs, Kristine Bertheussen, Hanieh K Abedian, Aidan V Johnson, Nicholas M Pearce, Martin Lutz, Johan Kemmink, Tjalling Seirsma, Leendert W Hamoen, Bert J C Janssen, Nathaniel I Martin
Mechanistic insights into the C 55 -P targeting lipopeptide antibiotics revealed by structure-activity studies and high-resolution crystal structures. Chemical science 13 (10) (2022)
Yurui Zhang, Matthijs J van Haren, Nils Marechal, Nathalie Troffer-Charlier, Vincent Cura, Jean Cavarelli, Nathaniel I Martin
A Direct Assay for Measuring the Activity and Inhibition of Coactivator-Associated Arginine Methyltransferase 1. Biochemistry (2022)
Karol Al Ayed, Ross D Ballantine, Michael Hoekstra, Samantha J Bann, Charlotte M J Wesseling, Alexander T Bakker, Zheng Zhong, Yong-Xin Li, Nora C Brüchle, Mario van der Stelt, Stephen A Cochrane, Nathaniel I Martin
Synthetic studies with the brevicidine and laterocidine lipopeptide antibiotics including analogues with enhanced properties and in vivo efficacy. Chemical science 13 (12) (2022)
Ross D Ballantine, Karol Al Ayed, Samantha J Bann, Michael Hoekstra, Nathaniel I Martin, Stephen A Cochrane
Synthesis and structure-activity relationship studies of N-terminal analogues of the lipopeptide antibiotics brevicidine and laterocidine. RSC medicinal chemistry 13 (12) (2022)
Alexander T Bakker, Ioli Kotsogianni, Liza Mirenda, Verena M Straub, Mariana Avalos, Richard J B H N van den Berg, Bogdan I Florea, Gilles P van Wezel, Antonius P A Janssen, Nathaniel I Martin, Mario van der Stelt
Chemical Proteomics Reveals Antibiotic Targets of Oxadiazolones in MRSA. Journal of the American Chemical Society 145 (2) (2022)
Alexander T Bakker, Ioli Kotsogianni, Liza Mirenda, Verena M Straub, Mariana Avalos, Richard J B H N van den Berg, Bogdan I Florea, Gilles P van Wezel, Antonius P A Janssen, Nathaniel I Martin, Mario van der Stelt
Chemical Proteomics Reveals Antibiotic Targets of Oxadiazolones in MRSA. Journal of the American Chemical Society 145 (2) (2022)
Cornelis J Slingerland, Ioli Kotsogianni, Charlotte M J Wesseling, Nathaniel I Martin
Polymyxin Stereochemistry and Its Role in Antibacterial Activity and Outer Membrane Disruption. ACS infectious diseases (2022)
Ross D Ballantine, Karol Al Ayed, Samantha J Bann, Michael Hoekstra, Nathaniel I Martin, Stephen A Cochrane
Synthesis and structure-activity relationship studies of N-terminal analogues of the lipopeptide antibiotics brevicidine and laterocidine. RSC medicinal chemistry 13 (12) (2022)
Ioli Kotsogianni, Thomas M Wood, Francesca M Alexander, Stephen A Cochrane, Nathaniel I Martin
Binding Studies Reveal Phospholipid Specificity and Its Role in the Calcium-Dependent Mechanism of Action of Daptomycin. ACS infectious diseases 7 (9) (2021)
Kamaleddin H M E Tehrani, Nicola Wade, Vida Mashayekhi, Nora C Brüchle, Willem Jespers, Koen Voskuil, Diego Pesce, Matthijs J van Haren, Gerard van Westen, Nathaniel I Martin
Novel Cephalosporin Conjugates Display Potent and Selective Inhibition of Imipenemase-Type Metallo-β-Lactamases. Journal of medicinal chemistry 64 (13) (2021)
Matthijs J van Haren, Yurui Zhang, Vito Thijssen, Ned Buijs, Yongzhi Gao, Lukasz Mateuszuk, Filip A Fedak, Agnieszka Kij, Roberto Campagna, Davide Sartini, Monica Emanuelli, Stefan Chlopicki, Seino A K Jongkees, Nathaniel I Martin
Macrocyclic peptides as allosteric inhibitors of nicotinamide N-methyltransferase (NNMT). RSC chemical biology 2 (5) (2021)
Emma van Groesen, Cornelis J Slingerland, Paolo Innocenti, Milos Mihajlovic, Rosalinde Masereeuw, Nathaniel I Martin
Vancomyxins: Vancomycin-Polymyxin Nonapeptide Conjugates That Retain Anti-Gram-Positive Activity with Enhanced Potency against Gram-Negative Strains. ACS infectious diseases 7 (9) (2021)
Charlotte M J Wesseling, Cornelis J Slingerland, Shanice Veraar, Samantha Lok, Nathaniel I Martin
Structure-Activity Studies with Bis-Amidines That Potentiate Gram-Positive Specific Antibiotics against Gram-Negative Pathogens. ACS infectious diseases 7 (12) (2021)
Yurui Zhang, Nils Marechal, Matthijs J van Haren, Nathalie Troffer-Charlier, Vincent Cura, Jean Cavarelli, Nathaniel I Martin
Structural Studies Provide New Insights into the Role of Lysine Acetylation on Substrate Recognition by CARM1 and Inform the Design of Potent Peptidomimetic Inhibitors. Chembiochem : a European journal of chemical biology 22 (24) (2021)
Yongzhi Gao, Matthijs J van Haren, Ned Buijs, Paolo Innocenti, Yurui Zhang, Davide Sartini, Roberto Campagna, Monica Emanuelli, Richard B Parsons, Willem Jespers, Hugo Gutiérrez-de-Terán, Gerard van Westen, Nathaniel I Martin
Potent Inhibition of Nicotinamide N-Methyltransferase by Alkene-Linked Bisubstrate Mimics Bearing Electron Deficient Aromatics. Journal of medicinal chemistry 64 (17) (2021)
Nicola Wade, Kamaleddin H M E Tehrani, Nora C Brüchle, Matthijs J van Haren, Vida Mashayekhi, Nathaniel I Martin
Mechanistic Investigations of Metallo-β-lactamase Inhibitors: Strong Zinc Binding Is Not Required for Potent Enzyme Inhibition*. ChemMedChem 16 (10) (2021)
Thomas M Wood, Cornelis J Slingerland, Nathaniel I Martin
A Convenient Chemoenzymatic Preparation of Chimeric Macrocyclic Peptide Antibiotics with Potent Activity against Gram-Negative Pathogens. Journal of medicinal chemistry 64 (15) (2021)
Matthijs J van Haren, Kamaleddin H M E Tehrani, Ioli Kotsogianni, Nicola Wade, Nora C Brüchle, Vida Mashayekhi, Nathaniel I Martin
Cephalosporin Prodrug Inhibitors Overcome Metallo-β-Lactamase Driven Antibiotic Resistance. Chemistry (Weinheim an der Bergstrasse, Germany) 27 (11) (2021)
Kamaleddin H M E Tehrani, Haigen Fu, Nora C Brüchle, Vida Mashayekhi, Alejandro Prats Luján, Matthijs J van Haren, Gerrit J Poelarends, Nathaniel I Martin
Aminocarboxylic acids related to aspergillomarasmine A (AMA) and ethylenediamine-N,N'-disuccinic acid (EDDS) are strong zinc-binders and inhibitors of the metallo-beta-lactamase NDM-1. Chemical communications (Cambridge, England) 56 (20) (2020)
Liubov Yakovlieva, Thomas M Wood, Johan Kemmink, Ioli Kotsogianni, Franziska Koller, Jürgen Lassak, Nathaniel I Martin, Marthe T C Walvoort
A β-hairpin epitope as novel structural requirement for protein arginine rhamnosylation. Chemical science 12 (4) (2020)
Kamaleddin H M E Tehrani, Nora C Brüchle, Nicola Wade, Vida Mashayekhi, Diego Pesce, Matthijs J van Haren, Nathaniel I Martin
Small Molecule Carboxylates Inhibit Metallo-β-lactamases and Resensitize Carbapenem-Resistant Bacteria to Meropenem. ACS infectious diseases 6 (6) (2020)
Yongzhi Gao, Matthijs J van Haren, Ed E Moret, Johannes J M Rood, Davide Sartini, Alessia Salvucci, Monica Emanuelli, Pierrick Craveur, Nicolas Babault, Jian Jin, Nathaniel I Martin
Bisubstrate Inhibitors of Nicotinamide N-Methyltransferase (NNMT) with Enhanced Activity. Journal of medicinal chemistry 62 (14) (2019)
Thomas M Wood, Nathaniel I Martin
The calcium-dependent lipopeptide antibiotics: structure, mechanism, & medicinal chemistry. MedChemComm 10 (5) (2019)
Kamaleddin H M E Tehrani, Nathaniel I Martin
β-lactam/β-lactamase inhibitor combinations: an update. MedChemComm 9 (9) (2018)
Hannah L Bolt, Laurens H J Kleijn, Nathaniel I Martin, Steven L Cobb
Synthesis of Antibacterial Nisin⁻Peptoid Hybrids Using Click Methodology. Molecules (Basel, Switzerland) 23 (7) (2018)
Alen Sevšek, Javier Sastre Toraño, Linda Quarles van Ufford, Ed E Moret, Roland J Pieters, Nathaniel I Martin
Orthoester functionalized N-guanidino derivatives of 1,5-dideoxy-1,5-imino-d-xylitol as pH-responsive inhibitors of β-glucocerebrosidase. MedChemComm 8 (11) (2017)
Jennifer I Brown, Timo Koopmans, Jolinde van Strien, Nathaniel I Martin, Adam Frankel
Kinetic Analysis of PRMT1 Reveals Multifactorial Processivity and a Sequential Ordered Mechanism. Chembiochem : a European journal of chemical biology 19 (1) (2017)
Kamaleddin Haj Mohammad Ebrahim Tehrani, Nathaniel I Martin
Thiol-Containing Metallo-β-Lactamase Inhibitors Resensitize Resistant Gram-Negative Bacteria to Meropenem. ACS infectious diseases 3 (10) (2017)
Laurens H J Kleijn, Hedwich C Vlieg, Thomas M Wood, Javier Sastre Toraño, Bert J C Janssen, Nathaniel I Martin
A High-Resolution Crystal Structure that Reveals Molecular Details of Target Recognition by the Calcium-Dependent Lipopeptide Antibiotic Laspartomycin C. Angewandte Chemie (International ed. in English) 56 (52) (2017)
Alexander Bergstrom, Andrew Katko, Zach Adkins, Jessica Hill, Zishuo Cheng, Mia Burnett, Hao Yang, Mahesh Aitha, M Rachel Mehaffey, Jennifer S Brodbelt, Kamaleddin H M E Tehrani, Nathaniel I Martin, Robert A Bonomo, Richard C Page, David L Tierney, Walter Fast, Gerard D Wright, Michael W Crowder
Probing the Interaction of Aspergillomarasmine A with Metallo-β-lactamases NDM-1, VIM-2, and IMP-7. ACS infectious diseases 4 (2) (2017)
Peter 't Hart, Thomas M Wood, Kamaleddin Haj Mohammad Ebrahim Tehrani, Roel M van Harten, Małgorzata Śleszyńska, Inmaculada Rentero Rebollo, Antoni P A Hendrickx, Rob J L Willems, Eefjan Breukink, Nathaniel I Martin
De novo identification of lipid II binding lipopeptides with antibacterial activity against vancomycin-resistant bacteria. Chemical science 8 (12) (2017)