Hin Chu

Scopus Author ID ORCID

Publication Activity (10 Years)

Years Active: 2019-2024
Publications (10 Years): 66

Top Topics

Dendritic Cells

Top Venues

Signal transduction and targeted therapy

Nature communications

Emerging microbes & infections

This page only lists publications with an associated author ORCID identifier.

Publications

Jasper Fuk-Woo Chan, Shuo-Feng Yuan, Hin Chu, Siddharth Sridhar, Kwok-Yung Yuen
COVID-19 drug discovery and treatment options. Nature reviews. Microbiology 22 (7) (2024)
Jasper Fuk-Woo Chan, Shuo-Feng Yuan, Hin Chu, Siddharth Sridhar, Kwok-Yung Yuen
COVID-19 drug discovery and treatment options. Nature reviews. Microbiology (2024)
Jasper Fuk-Woo Chan, Shuo-Feng Yuan, Hin Chu, Siddharth Sridhar, Kwok-Yung Yuen
COVID-19 drug discovery and treatment options. Nature reviews. Microbiology 22 (7) (2024)
Ronghui Liang, Zi-Wei Ye, Zhenzhi Qin, Yubin Xie, Xiaomeng Yang, Haoran Sun, Qiaohui Du, Peng Luo, Kaiming Tang, Bodan Hu, Jianli Cao, Xavier Hoi-Leong Wong, Guang-Sheng Ling, Hin Chu, Jiangang Shen, Feifei Yin, Dong-Yan Jin, Jasper Fuk-Woo Chan, Kwok-Yung Yuen, Shuo-Feng Yuan
PMI-controlled mannose metabolism and glycosylation determines tissue tolerance and virus fitness. Nature communications 15 (1) (2024)
Charles W F Chan, Bei Wang, Lang Nan, Xiner Huang, Tianjiao Mao, Hoi Yee Chu, Cuiting Luo, Hin Chu, Gigi C G Choi, Ho Cheung Shum, Alan S L Wong
Author Correction: High-throughput screening of genetic and cellular drivers of syncytium formation induced by the spike protein of SARS-CoV-2. Nature biomedical engineering (2024)
Ronghui Liang, Zi-Wei Ye, Zhenzhi Qin, Yubin Xie, Xiaomeng Yang, Haoran Sun, Qiaohui Du, Peng Luo, Kaiming Tang, Bodan Hu, Jianli Cao, Xavier Hoi-Leong Wong, Guang-Sheng Ling, Hin Chu, Jiangang Shen, Feifei Yin, Dong-Yan Jin, Jasper Fuk-Woo Chan, Kwok-Yung Yuen, Shuo-Feng Yuan
PMI-controlled mannose metabolism and glycosylation determines tissue tolerance and virus fitness. Nature communications 15 (1) (2024)
Charles W F Chan, Bei Wang, Lang Nan, Xiner Huang, Tianjiao Mao, Hoi Yee Chu, Cuiting Luo, Hin Chu, Gigi C G Choi, Ho Cheung Shum, Alan S L Wong
Author Correction: High-throughput screening of genetic and cellular drivers of syncytium formation induced by the spike protein of SARS-CoV-2. Nature biomedical engineering (2024)
Xiaoyu Zhao, Tianyi Qiu, Xiner Huang, Qiyu Mao, Yajie Wang, Rui Qiao, Jiayan Li, Tiantian Mao, Yuan Wang, Yewei Cun, Caicui Wang, Cuiting Luo, Chaemin Yoon, Xun Wang, Chen Li, Yuchen Cui, Chaoyue Zhao, Minghui Li, Yanjia Chen, Guonan Cai, Wenye Geng, Zixin Hu, Jinglei Cao, Wenhong Zhang, Zhiwei Cao, Hin Chu, Lei Sun, Pengfei Wang
Potent and broadly neutralizing antibodies against sarbecoviruses induced by sequential COVID-19 vaccination. Cell discovery 10 (1) (2024)
Ronghui Liang, Zi-Wei Ye, Zhenzhi Qin, Yubin Xie, Xiaomeng Yang, Haoran Sun, Qiaohui Du, Peng Luo, Kaiming Tang, Bodan Hu, Jianli Cao, Xavier Hoi-Leong Wong, Guang-Sheng Ling, Hin Chu, Jiangang Shen, Feifei Yin, Dong-Yan Jin, Jasper Fuk-Woo Chan, Kwok-Yung Yuen, Shuo-Feng Yuan
PMI-controlled mannose metabolism and glycosylation determines tissue tolerance and virus fitness. Nature communications 15 (1) (2024)
Jasper Fuk-Woo Chan, Shuo-Feng Yuan, Hin Chu, Siddharth Sridhar, Kwok-Yung Yuen
COVID-19 drug discovery and treatment options. Nature reviews. Microbiology 22 (7) (2024)
Xiaoyu Zhao, Tianyi Qiu, Xiner Huang, Qiyu Mao, Yajie Wang, Rui Qiao, Jiayan Li, Tiantian Mao, Yuan Wang, Yewei Cun, Caicui Wang, Cuiting Luo, Chaemin Yoon, Xun Wang, Chen Li, Yuchen Cui, Chaoyue Zhao, Minghui Li, Yanjia Chen, Guonan Cai, Wenye Geng, Zixin Hu, Jinglei Cao, Wenhong Zhang, Zhiwei Cao, Hin Chu, Lei Sun, Pengfei Wang
Potent and broadly neutralizing antibodies against sarbecoviruses induced by sequential COVID-19 vaccination. Cell discovery 10 (1) (2024)
Chong Huang, Huiping Shuai, Jingxin Qiao, Yuxin Hou, Rui Zeng, An-Jie Xia, Lingwan Xie, Zhen Fang, Yueyue Li, Chaemin Yoon, Qiao Huang, Bingjie Hu, Jing You, Baoxue Quan, Xiu Zhao, Nihong Guo, Shiyu Zhang, Ronggang Ma, Jiahao Zhang, Yifei Wang, Ruicheng Yang, Shanshan Zhang, Jinshan Nan, Haixing Xu, Falu Wang, Jian Lei, Hin Chu, Shengyong Yang
A new generation M pro inhibitor with potent activity against SARS-CoV-2 Omicron variants. Signal transduction and targeted therapy 8 (1) (2023)
Jasper Fuk-Woo Chan, Xiner Huang, Bingjie Hu, Yue Chai, Hongyu Shi, Tianrenzheng Zhu, Terrence Tsz-Tai Yuen, Yuanchen Liu, Huan Liu, Jialu Shi, Lei Wen, Huiping Shuai, Yuxin Hou, Chaemin Yoon, Jian-Piao Cai, Anna Jinxia Zhang, Jie Zhou, Feifei Yin, Shuo-Feng Yuan, Bao-Zhong Zhang, Melinda Ann Brindley, Zheng-Li Shi, Kwok-Yung Yuen, Hin Chu
Altered host protease determinants for SARS-CoV-2 Omicron. Science advances 9 (3) (2023)
Jian-Piao Cai, Cuiting Luo, Kun Wang, Hehe Cao, Lin-Lei Chen, Xiaojuan Zhang, Yuting Han, Feifei Yin, Anna Jinxia Zhang, Hin Chu, Shuo-Feng Yuan, Raven K H Kok, Kelvin Kai Wang To, Hong-Lin Chen, Zhiwei Chen, Dong-Yan Jin, Kwok-Yung Yuen, Jasper Fuk-Woo Chan
Intranasal Boosting with Spike Fc-RBD of Wild-Type SARS-CoV-2 Induces Neutralizing Antibodies against Omicron Subvariants and Reduces Viral Load in the Nasal Turbinate of Mice. Viruses 15 (3) (2023)
Jasper Fuk-Woo Chan, Xiner Huang, Bingjie Hu, Yue Chai, Hongyu Shi, Tianrenzheng Zhu, Terrence Tsz-Tai Yuen, Yuanchen Liu, Huan Liu, Jialu Shi, Lei Wen, Huiping Shuai, Yuxin Hou, Chaemin Yoon, Jian-Piao Cai, Anna Jinxia Zhang, Jie Zhou, Feifei Yin, Shuo-Feng Yuan, Bao-Zhong Zhang, Melinda Ann Brindley, Zheng-Li Shi, Kwok-Yung Yuen, Hin Chu
Altered host protease determinants for SARS-CoV-2 Omicron. Science advances 9 (3) (2023)
Chong Huang, Huiping Shuai, Jingxin Qiao, Yuxin Hou, Rui Zeng, An-Jie Xia, Lingwan Xie, Zhen Fang, Yueyue Li, Chaemin Yoon, Qiao Huang, Bingjie Hu, Jing You, Baoxue Quan, Xiu Zhao, Nihong Guo, Shiyu Zhang, Ronggang Ma, Jiahao Zhang, Yifei Wang, Ruicheng Yang, Shanshan Zhang, Jinshan Nan, Haixing Xu, Falu Wang, Jian Lei, Hin Chu, Shengyong Yang
A new generation M pro inhibitor with potent activity against SARS-CoV-2 Omicron variants. Signal transduction and targeted therapy 8 (1) (2023)
Chong Huang, Huiping Shuai, Jingxin Qiao, Yuxin Hou, Rui Zeng, An-Jie Xia, Lingwan Xie, Zhen Fang, Yueyue Li, Chaemin Yoon, Qiao Huang, Bingjie Hu, Jing You, Baoxue Quan, Xiu Zhao, Nihong Guo, Shiyu Zhang, Ronggang Ma, Jiahao Zhang, Yifei Wang, Ruicheng Yang, Shanshan Zhang, Jinshan Nan, Haixing Xu, Falu Wang, Jian Lei, Hin Chu, Shengyong Yang
A new generation M pro inhibitor with potent activity against SARS-CoV-2 Omicron variants. Signal transduction and targeted therapy 8 (1) (2023)
Jasper Fuk-Woo Chan, Xiner Huang, Bingjie Hu, Yue Chai, Hongyu Shi, Tianrenzheng Zhu, Terrence Tsz-Tai Yuen, Yuanchen Liu, Huan Liu, Jialu Shi, Lei Wen, Huiping Shuai, Yuxin Hou, Chaemin Yoon, Jian-Piao Cai, Anna Jinxia Zhang, Jie Zhou, Feifei Yin, Shuo-Feng Yuan, Bao-Zhong Zhang, Melinda Ann Brindley, Zheng-Li Shi, Kwok-Yung Yuen, Hin Chu
Altered host protease determinants for SARS-CoV-2 Omicron. Science advances 9 (3) (2023)
Jian-Piao Cai, Cuiting Luo, Kun Wang, Hehe Cao, Lin-Lei Chen, Xiaojuan Zhang, Yuting Han, Feifei Yin, Anna Jinxia Zhang, Hin Chu, Shuo-Feng Yuan, Raven K H Kok, Kelvin Kai Wang To, Hong-Lin Chen, Zhiwei Chen, Dong-Yan Jin, Kwok-Yung Yuen, Jasper Fuk-Woo Chan
Intranasal Boosting with Spike Fc-RBD of Wild-Type SARS-CoV-2 Induces Neutralizing Antibodies against Omicron Subvariants and Reduces Viral Load in the Nasal Turbinate of Mice. Viruses 15 (3) (2023)
Charles W F Chan, Bei Wang, Lang Nan, Xiner Huang, Tianjiao Mao, Hoi Yee Chu, Cuiting Luo, Hin Chu, Gigi C G Choi, Anderson H C Shum, Alan S L Wong
High-throughput screening of genetic and cellular drivers of syncytium formation induced by the spike protein of SARS-CoV-2. Nature biomedical engineering (2023)
Jian-Piao Cai, Cuiting Luo, Kun Wang, Hehe Cao, Lin-Lei Chen, Xiaojuan Zhang, Yuting Han, Feifei Yin, Anna Jinxia Zhang, Hin Chu, Shuo-Feng Yuan, Raven K H Kok, Kelvin Kai Wang To, Hong-Lin Chen, Zhiwei Chen, Dong-Yan Jin, Kwok-Yung Yuen, Jasper Fuk-Woo Chan
Intranasal Boosting with Spike Fc-RBD of Wild-Type SARS-CoV-2 Induces Neutralizing Antibodies against Omicron Subvariants and Reduces Viral Load in the Nasal Turbinate of Mice. Viruses 15 (3) (2023)
Jasper Fuk-Woo Chan, Xiner Huang, Bingjie Hu, Yue Chai, Hongyu Shi, Tianrenzheng Zhu, Terrence Tsz-Tai Yuen, Yuanchen Liu, Huan Liu, Jialu Shi, Lei Wen, Huiping Shuai, Yuxin Hou, Chaemin Yoon, Jian-Piao Cai, Anna Jinxia Zhang, Jie Zhou, Feifei Yin, Shuo-Feng Yuan, Bao-Zhong Zhang, Melinda Ann Brindley, Zheng-Li Shi, Kwok-Yung Yuen, Hin Chu
Altered host protease determinants for SARS-CoV-2 Omicron. Science advances 9 (3) (2023)
Chong Huang, Huiping Shuai, Jingxin Qiao, Yuxin Hou, Rui Zeng, An-Jie Xia, Lingwan Xie, Zhen Fang, Yueyue Li, Chaemin Yoon, Qiao Huang, Bingjie Hu, Jing You, Baoxue Quan, Xiu Zhao, Nihong Guo, Shiyu Zhang, Ronggang Ma, Jiahao Zhang, Yifei Wang, Ruicheng Yang, Shanshan Zhang, Jinshan Nan, Haixing Xu, Falu Wang, Jian Lei, Hin Chu, Shengyong Yang
A new generation M pro inhibitor with potent activity against SARS-CoV-2 Omicron variants. Signal transduction and targeted therapy 8 (1) (2023)
Xiaolei Wang, Terrence Tsz-Tai Yuen, Ying Dou, Jingchu Hu, Renhao Li, Zheng Zeng, Xuansheng Lin, Huarui Gong, Celia Hoi-Ching Chan, Chaemin Yoon, Huiping Shuai, Deborah Tip-Yin Ho, Ivan Fan-Ngai Hung, Bao-Zhong Zhang, Hin Chu, Jian-Dong Huang
Vaccine-induced protection against SARS-CoV-2 requires IFN-γ-driven cellular immune response. Nature communications 14 (1) (2023)
Ye-Fan Hu, Jing-Chu Hu, Hin Chu, Thomas Yau, Bao-Zhong Zhang, Jian-Dong Huang
In-Silico Analysis of Monoclonal Antibodies against SARS-CoV-2 Omicron. Viruses 14 (2) (2022)
Wei Qiao, Hui En Lau, Huizhi Xie, Vincent Kwok-Man Poon, Chris Chung-Sing Chan, Hin Chu, Shuofeng Yuan, Terrence Tsz-Tai Yuen, Kenn Ka-Heng Chik, Jessica Oi-Ling Tsang, Chris Chun-Yiu Chan, Jian-Piao Cai, Cuiting Luo, Kwok-Yung Yuen, Kenneth Man-Chee Cheung, Jasper Fuk-Woo Chan, Kelvin Wai-Kwok Yeung
Author Correction: SARS-CoV-2 infection induces inflammatory bone loss in golden Syrian hamsters. Nature communications 13 (1) (2022)
Yuxin Hou, Chang Li, Chaemin Yoon, On Wah Leung, Sikun You, Xiaoming Cui, Jasper Fuk-Woo Chan, Duanqing Pei, Hoi Hung Cheung, Hin Chu
Enhanced replication of SARS-CoV-2 Omicron BA.2 in human forebrain and midbrain organoids. Signal transduction and targeted therapy 7 (1) (2022)
Hin Chu, Kwok-Yung Yuen
Pathogenicity of SARS-CoV-2 Omicron. Clinical and translational medicine 12 (5) (2022)
Hin Chu, Yuxin Hou, Dong Yang, Lei Wen, Huiping Shuai, Chaemin Yoon, Jialu Shi, Yue Chai, Terrence Tsz-Tai Yuen, Bingjie Hu, Cun Li, Xiaoyu Zhao, Yixin Wang, Xiner Huang, Kin Shing Lee, Cuiting Luo, Jian-Piao Cai, Vincent Kwok-Man Poon, Chris Chung-Sing Chan, Anna Jian-Xia Zhang, Shuofeng Yuan, Ko-Yung Sit, Dominic Chi-Chung Foo, Wing-Kuk Au, Kenneth Kak Yuen Wong, Jie Zhou, Raven K H Kok, Dong-Yan Jin, Jasper Fuk-Woo Chan, Kwok-Yung Yuen
Coronaviruses exploit a host cysteine-aspartic protease for replication. Nature 609 (7928) (2022)
Wei Qiao, Hui En Lau, Huizhi Xie, Vincent Kwok-Man Poon, Chris Chung-Sing Chan, Hin Chu, Shuofeng Yuan, Terrence Tsz-Tai Yuen, Kenn Ka-Heng Chik, Jessica Oi-Ling Tsang, Chris Chun-Yiu Chan, Jian-Piao Cai, Cuiting Luo, Kwok-Yung Yuen, Kenneth Man-Chee Cheung, Jasper Fuk-Woo Chan, Kelvin Wai-Kwok Yeung
SARS-CoV-2 infection induces inflammatory bone loss in golden Syrian hamsters. Nature communications 13 (1) (2022)
Bingjie Hu, Jasper Fuk-Woo Chan, Huan Liu, Yuanchen Liu, Yue Chai, Jialu Shi, Huiping Shuai, Yuxin Hou, Xiner Huang, Terrence Tsz-Tai Yuen, Chaemin Yoon, Tianrenzheng Zhu, Jinjin Zhang, Wenjun Li, Anna Jian-Xia Zhang, Jie Zhou, Shuo-Feng Yuan, Bao-Zhong Zhang, Kwok-Yung Yuen, Hin Chu
Spike mutations contributing to the altered entry preference of SARS-CoV-2 omicron BA.1 and BA.2. Emerging microbes & infections 11 (1) (2022)
Shuai Xia, Jasper Fuk-Woo Chan, Lijue Wang, Fanke Jiao, Kenn Ka-Heng Chik, Hin Chu, Qiaoshuai Lan, Wei Xu, Qian Wang, Chao Wang, Kwok-Yung Yuen, Lu Lu, Shibo Jiang
Peptide-based pan-CoV fusion inhibitors maintain high potency against SARS-CoV-2 Omicron variant. Cell research 32 (4) (2022)
Xiaojuan Liu, Cun Li, Zhixin Wan, Man Chun Chiu, Jingjing Huang, Yifei Yu, Lin Zhu, Jian-Piao Cai, Lei Rong, You-Qiang Song, Hin Chu, Zongwei Cai, Shibo Jiang, Kwok-Yung Yuen, Jie Zhou
Analogous comparison unravels heightened antiviral defense and boosted viral infection upon immunosuppression in bat organoids. Signal transduction and targeted therapy 7 (1) (2022)
Xi Zhang, Hin Chu, Kenn Ka-Heng Chik, Lei Wen, Huiping Shuai, Dong Yang, Yixin Wang, Yuxin Hou, Terrence Tsz-Tai Yuen, Jian-Piao Cai, Shuo-Feng Yuan, Feifei Yin, Kwok-Yung Yuen, Jasper Fuk-Woo Chan
hnRNP C modulates MERS-CoV and SARS-CoV-2 replication by governing the expression of a subset of circRNAs and cognitive mRNAs. Emerging microbes & infections 11 (1) (2022)
Huiping Shuai, Jasper Fuk-Woo Chan, Bingjie Hu, Yue Chai, Terrence Tsz-Tai Yuen, Feifei Yin, Xiner Huang, Chaemin Yoon, Jing-Chu Hu, Huan Liu, Jialu Shi, Yuanchen Liu, Tianrenzheng Zhu, Jinjin Zhang, Yuxin Hou, Yixin Wang, Lu Lu, Jian-Piao Cai, Anna Jian-Xia Zhang, Jie Zhou, Shuofeng Yuan, Melinda A Brindley, Bao-Zhong Zhang, Jian-Dong Huang, Kelvin Kai Wang To, Kwok-Yung Yuen, Hin Chu
Attenuated replication and pathogenicity of SARS-CoV-2 B.1.1.529 Omicron. Nature 603 (7902) (2022)
Xiaojuan Liu, Cun Li, Zhixin Wan, Man Chun Chiu, Jingjing Huang, Yifei Yu, Lin Zhu, Jian-Piao Cai, Lei Rong, You-Qiang Song, Hin Chu, Zongwei Cai, Shibo Jiang, Kwok-Yung Yuen, Jie Zhou
Analogous comparison unravels heightened antiviral defense and boosted viral infection upon immunosuppression in bat organoids. Signal transduction and targeted therapy 7 (1) (2022)
Sho Iketani, Lihong Liu, Yicheng Guo, Liyuan Liu, Jasper Fuk-Woo Chan, Yiming Huang, Maple Wang, Yang Luo, Jian Yu, Hin Chu, Kenn K-H Chik, Terrence T-T Yuen, Michael T Yin, Magdalena E Sobieszczyk, Yaoxing Huang, Kwok-Yung Yuen, Harris H Wang, Zizhang Sheng, David D Ho
Antibody evasion properties of SARS-CoV-2 Omicron sublineages. Nature 604 (7906) (2022)
Zi-Wei Ye, Chon Phin Ong, Kaiming Tang, Yilan Fan, Cuiting Luo, Runhong Zhou, Peng Luo, Yun Cheng, Victor Sebastien Gray, Pui Wang, Hin Chu, Jasper Fuk-Woo Chan, Kelvin Kai Wang To, Honglin Chen, Zhiwei Chen, Kwok-Yung Yuen, Guang Sheng Ling, Shuofeng Yuan, Dong-Yan Jin
Intranasal administration of a single dose of a candidate live attenuated vaccine derived from an NSP16-deficient SARS-CoV-2 strain confers sterilizing immunity in animals. Cellular & molecular immunology 19 (5) (2022)
Bodan Hu, Kenn Ka-Heng Chik, Jasper Fuk-Woo Chan, Jian-Piao Cai, Hehe Cao, Jessica Oi-Ling Tsang, Zijiao Zou, Yin-Po Hung, Kaiming Tang, Lilong Jia, Cuiting Luo, Feifei Yin, Zi-Wei Ye, Hin Chu, Man-Lung Yeung, Shuo-Feng Yuan
Vemurafenib Inhibits Enterovirus A71 Genome Replication and Virus Assembly. Pharmaceuticals (Basel, Switzerland) 15 (9) (2022)
Lihong Liu, Sho Iketani, Yicheng Guo, Eswar R Reddem, Ryan G Casner, Manoj S Nair, Jian Yu, Jasper Fuk-Woo Chan, Maple Wang, Gabriele Cerutti, Zhiteng Li, Nicholas C Morano, Candace D Castagna, Laura Corredor, Hin Chu, Shuo-Feng Yuan, Vincent Kwok-Man Poon, Chris Chung-Sing Chan, Zhiwei Chen, Yang Luo, Marcus Cunningham, Alejandro Chavez, Michael T Yin, David S Perlin, Moriya Tsuji, Kwok-Yung Yuen, Peter D Kwong, Zizhang Sheng, Yaoxing Huang, Lawrence Shapiro, David D Ho
An antibody class with a common CDRH3 motif broadly neutralizes sarbecoviruses. Science translational medicine 14 (646) (2022)
Shuo-Feng Yuan, Zi-Wei Ye, Ronghui Liang, Kaiming Tang, Anna Jinxia Zhang, Gang Lu, Chon Phin Ong, Vincent Kwok-Man Poon, Chris Chung-Sing Chan, Bobo Wing-Yee Mok, Zhenzhi Qin, Yubin Xie, Allen Wing-Ho Chu, Wan-Mui Chan, Jonathan Daniel Ip, Haoran Sun, Jessica Oi-Ling Tsang, Terrence Tsz-Tai Yuen, Kenn Ka-Heng Chik, Chris Chun-Yiu Chan, Jian-Piao Cai, Cuiting Luo, Lu Lu, Cyril Chik-Yan Yip, Hin Chu, Kelvin Kai Wang To, Hong-Lin Chen, Dong-Yan Jin, Kwok-Yung Yuen, Jasper Fuk-Woo Chan
Pathogenicity, transmissibility, and fitness of SARS-CoV-2 Omicron in Syrian hamsters. Science (New York, N.Y.) 377 (6604) (2022)
Ronghui Liang, Zi-Wei Ye, Chon Phin Ong, Zhenzhi Qin, Yubin Xie, Yilan Fan, Kaiming Tang, Vincent Kwok-Man Poon, Chris Chung-Sing Chan, Xiaomeng Yang, Hehe Cao, Kun Wang, Haoran Sun, Bodan Hu, Jian-Piao Cai, Cuiting Luo, Kenn Ka-Heng Chik, Hin Chu, Yi Zheng, Kwok-Yung Yuen, Jasper Fuk-Woo Chan, Dong-Yan Jin, Shuo-Feng Yuan
The spike receptor-binding motif G496S substitution determines the replication fitness of SARS-CoV-2 Omicron sublineage. Emerging microbes & infections 11 (1) (2022)
Yanxia Chen, Can Li, Feifei Liu, Zhanhong Ye, Wenchen Song, Andrew C Y Lee, Huiping Shuai, Lu Lu, Kelvin Kai Wang To, Jasper Fuk-Woo Chan, Anna Jian-Xia Zhang, Hin Chu, Kwok-Yung Yuen
Age-associated SARS-CoV-2 breakthrough infection and changes in immune response in a mouse model. Emerging microbes & infections 11 (1) (2022)
Bao-Xue Quan, Huiping Shuai, An-Jie Xia, Yuxin Hou, Rui Zeng, Xin-Lei Liu, Gui-Feng Lin, Jing-Xin Qiao, Wen-Pei Li, Fa-Lu Wang, Kai Wang, Ren-Jie Zhou, Terrence Tsz-Tai Yuen, Ming-Xin Chen, Chaemin Yoon, Ming Wu, Shi-Yu Zhang, Chong Huang, Yi-Fei Wang, Wei Yang, Chenyu Tian, Wei-Min Li, Yu-Quan Wei, Kwok-Yung Yuen, Jasper Fuk-Woo Chan, Jian Lei, Hin Chu, Sheng-Yong Yang
An orally available M pro inhibitor is effective against wild-type SARS-CoV-2 and variants including Omicron. Nature microbiology 7 (5) (2022)
Man-Chun Chiu, Cun Li, Xiaojuan Liu, Yifei Yu, Jingjing Huang, Zhixin Wan, Ding Xiao, Hin Chu, Jian-Piao Cai, Biao Zhou, Ko-Yung Sit, Wing-Kuk Au, Kenneth Kak-Yuen Wong, Gang Li, Jasper Fuk-Woo Chan, Kelvin Kai Wang To, Zhiwei Chen, Shibo Jiang, Hans Clevers, Kwok-Yung Yuen, Jie Zhou
A bipotential organoid model of respiratory epithelium recapitulates high infectivity of SARS-CoV-2 Omicron variant. Cell discovery 8 (1) (2022)
Xiaojuan Liu, Cun Li, Zhixin Wan, Man Chun Chiu, Jingjing Huang, Yifei Yu, Lin Zhu, Jian-Piao Cai, Lei Rong, You-Qiang Song, Hin Chu, Zongwei Cai, Shibo Jiang, Kwok-Yung Yuen, Jie Zhou
Analogous comparison unravels heightened antiviral defense and boosted viral infection upon immunosuppression in bat organoids. Signal transduction and targeted therapy 7 (1) (2022)
Xiaojuan Liu, Cun Li, Zhixin Wan, Man Chun Chiu, Jingjing Huang, Yifei Yu, Lin Zhu, Jian-Piao Cai, Lei Rong, You-Qiang Song, Hin Chu, Zongwei Cai, Shibo Jiang, Kwok-Yung Yuen, Jie Zhou
Analogous comparison unravels heightened antiviral defense and boosted viral infection upon immunosuppression in bat organoids. Signal transduction and targeted therapy 7 (1) (2022)
Biao Zhou, Runhong Zhou, Bingjie Tang, Jasper Fuk-Woo Chan, Mengxiao Luo, Qiaoli Peng, Shuofeng Yuan, Hang Liu, Bobo Wing-Yee Mok, Bohao Chen, Pui Wang, Vincent Kwok-Man Poon, Hin Chu, Chris Chung-Sing Chan, Jessica Oi-Ling Tsang, Chris Chun-Yiu Chan, Ka-Kit Au, Hiu-On Man, Lu Lu, Kelvin Kai Wang To, Hong-Lin Chen, Kwok-Yung Yuen, Shangyu Dang, Zhiwei Chen
A broadly neutralizing antibody protects Syrian hamsters against SARS-CoV-2 Omicron challenge. Nature communications 13 (1) (2022)
Lihong Liu, Sho Iketani, Yicheng Guo, Jasper Fuk-Woo Chan, Maple Wang, Liyuan Liu, Yang Luo, Hin Chu, Yiming Huang, Manoj S Nair, Jian Yu, Kenn K-H Chik, Terrence T-T Yuen, Chaemin Yoon, Kelvin Kai Wang To, Hong-Lin Chen, Michael T Yin, Magdalena E Sobieszczyk, Yaoxing Huang, Harris H Wang, Zizhang Sheng, Kwok-Yung Yuen, David D Ho
Striking antibody evasion manifested by the Omicron variant of SARS-CoV-2. Nature 602 (7898) (2021)
Dong Yang, Hin Chu, Gang Lu, Huiping Shuai, Yixin Wang, Yuxin Hou, Xi Zhang, Xiner Huang, Bingjie Hu, Yue Chai, Terrence Tsz-Tai Yuen, Xiaoyu Zhao, Andrew Chak-Yiu Lee, Zi-Wei Ye, Cun Li, Kenn Ka-Heng Chik, Anna Jian-Xia Zhang, Jie Zhou, Shuofeng Yuan, Jasper Fuk-Woo Chan
STAT2-dependent restriction of Zika virus by human macrophages but not dendritic cells. Emerging microbes & infections 10 (1) (2021)
Hin Chu, Huiping Shuai, Yuxin Hou, Xi Zhang, Lei Wen, Xiner Huang, Bingjie Hu, Dong Yang, Yixin Wang, Chaemin Yoon, Kenneth Kak Yuen Wong, Cun Li, Xiaoyu Zhao, Vincent Kwok-Man Poon, Jian-Piao Cai, Kenneth Kak-Yuen Wong, Man-Lung Yeung, Jie Zhou, Rex Kwok-Him Au-Yeung, Shuo-Feng Yuan, Dong-Yan Jin, Raven K H Kok, Stanley Perlman, Jasper Fuk-Woo Chan, Kwok-Yung Yuen
Targeting highly pathogenic coronavirus-induced apoptosis reduces viral pathogenesis and disease severity. Science advances 7 (25) (2021)
Bao-Zhong Zhang, Xiaolei Wang, Shuo-Feng Yuan, Wenjun Li, Ying Dou, Vincent Kwok-Man Poon, Chris Chung-Sing Chan, Jian-Piao Cai, Kenn KaHeng Chik, Kaiming Tang, Chris Chun-Yiu Chan, Ye-Fan Hu, Jing-Chu Hu, Smaranda Ruxandra Badea, Hua-Rui Gong, Xuansheng Lin, Hin Chu, Xuechen Li, Kelvin Kai Wang To, Li Liu, Zhiwei Chen, Ivan Fan-Ngai Hung, Kwok-Yung Yuen, Jasper Fuk-Woo Chan, Jian-Dong Huang
A novel linker-immunodominant site (LIS) vaccine targeting the SARS-CoV-2 spike protein protects against severe COVID-19 in Syrian hamsters. Emerging microbes & infections 10 (1) (2021)
Zi-Wei Ye, Shuo-Feng Yuan, Jasper Fuk-Woo Chan, Anna Jian-Xia Zhang, Ching-Yun Yu, Chon Phin Ong, Dong Yang, Chris Chun-Yiu Chan, Kaiming Tang, Jianli Cao, Vincent Kwok-Man Poon, Chris Chung-Sing Chan, Jian-Piao Cai, Hin Chu, Kwok-Yung Yuen, Dong-Yan Jin
Beneficial effect of combinational methylprednisolone and remdesivir in hamster model of SARS-CoV-2 infection. Emerging microbes & infections 10 (1) (2021)
Shuofeng Yuan, Bingpeng Yan, Jianli Cao, Zi-Wei Ye, Ronghui Liang, Kaiming Tang, Cuiting Luo, Jianpiao Cai, Hin Chu, Tom Wai-Hing Chung, Kelvin Kai Wang To, Ivan Fan-Ngai Hung, Dong-Yan Jin, Jasper Fuk-Woo Chan, Kwok-Yung Yuen
SARS-CoV-2 exploits host DGAT and ADRP for efficient replication. Cell discovery 7 (1) (2021)
Andrew Chak-Yiu Lee, Anna Jinxia Zhang, Can Li, Yanxia Chen, Feifei Liu, Yan Zhao, Hin Chu, Carol Ho-Yan Fong, Pui Wang, Siu-Ying Lau, Kelvin Kai Wang To, Honglin Chen, Kwok-Yung Yuen
Intradermal vaccination of live attenuated influenza vaccine protects mice against homologous and heterologous influenza challenges. NPJ vaccines 6 (1) (2021)
Jessica Oi-Ling Tsang, Jie Zhou, Xiaoyu Zhao, Cun Li, Zijiao Zou, Feifei Yin, Shuo-Feng Yuan, Man-Lung Yeung, Hin Chu, Jasper Fuk-Woo Chan
Development of Three-Dimensional Human Intestinal Organoids as a Physiologically Relevant Model for Characterizing the Viral Replication Kinetics and Antiviral Susceptibility of Enteroviruses. Biomedicines 9 (1) (2021)
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Targeting SUMO Modification of the Non-Structural Protein 5 of Zika Virus as a Host-Targeting Antiviral Strategy. International journal of molecular sciences 20 (2) (2019)
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