Hans Clevers (H Clevers)

ResearcherID ORCID

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 132

Top Venues

Proceedings of the National Academy of Sciences of the United States of America

Nature communications

Nature protocols

Science (New York, N.Y.)

Universitair Medisch Centrum Utrecht

This page only lists publications with an associated author ORCID identifier.

Affiliation History

Universitair Medisch Centrum Utrecht

Netherlands

Prof. dr.

Princess Máxima Center for Pediatric Oncology

Netherlands

CSO :: Research

Hubrecht Institute

Netherlands

Director Research

Publications

Delilah Hendriks, Benedetta Artegiani, Thanasis Margaritis, Iris Zoutendijk, Susana Chuva de Sousa Lopes, Hans Clevers
Mapping of mitogen and metabolic sensitivity in organoids defines requirements for human hepatocyte growth. Nature communications 15 (1) (2024)
Nicolas Alcala, Catherine Voegele, Lise Mangiante, Alexandra Sexton-Oates, Hans Clevers, Lynnette Fernandez-Cuesta, Talya L Dayton, Matthieu Foll
Multi-omic dataset of patient-derived tumor organoids of neuroendocrine neoplasms. GigaScience 13 (2024)
Peter D Haughton, Wisse Haakma, Theofilos Chalkiadakis, Gerben E Breimer, Else Driehuis, Hans Clevers, Stefan Willems, Stefan Prekovic, Patrick W B Derksen
Differential transcriptional invasion signatures from patient derived organoid models define a functional prognostic tool for head and neck cancer. Oncogene 43 (32) (2024)
Matteo Boretto, Maarten H Geurts, Shashank Gandhi, Ziliang Ma, Nadzeya Staliarova, Martina Celotti, Sangho Lim, Gui-Wei He, Rosemary Millen, Else Driehuis, Harry Begthel, Lidwien Smabers, Jeanine Roodhart, Johan van Es, Wei Wu, Hans Clevers
Epidermal growth factor receptor (EGFR) is a target of the tumor-suppressor E3 ligase FBXW7. Proceedings of the National Academy of Sciences of the United States of America 121 (12) (2024)
Peter D Haughton, Wisse Haakma, Theofilos Chalkiadakis, Gerben E Breimer, Else Driehuis, Hans Clevers, Stefan Willems, Stefan Prekovic, Patrick W B Derksen
Differential transcriptional invasion signatures from patient derived organoid models define a functional prognostic tool for head and neck cancer. Oncogene 43 (32) (2024)
Peter D Haughton, Wisse Haakma, Theofilos Chalkiadakis, Gerben E Breimer, Else Driehuis, Hans Clevers, Stefan Willems, Stefan Prekovic, Patrick W B Derksen
Differential transcriptional invasion signatures from patient derived organoid models define a functional prognostic tool for head and neck cancer. Oncogene 43 (32) (2024)
Nicolas Alcala, Catherine Voegele, Lise Mangiante, Alexandra Sexton-Oates, Hans Clevers, Lynnette Fernandez-Cuesta, Talya L Dayton, Matthieu Foll
Multi-omic dataset of patient-derived tumor organoids of neuroendocrine neoplasms. GigaScience 13 (2024)
Delilah Hendriks, Benedetta Artegiani, Thanasis Margaritis, Iris Zoutendijk, Susana Chuva de Sousa Lopes, Hans Clevers
Mapping of mitogen and metabolic sensitivity in organoids defines requirements for human hepatocyte growth. Nature communications 15 (1) (2024)
Matteo Boretto, Maarten H Geurts, Shashank Gandhi, Ziliang Ma, Nadzeya Staliarova, Martina Celotti, Sangho Lim, Gui-Wei He, Rosemary Millen, Else Driehuis, Harry Begthel, Lidwien Smabers, Jeanine Roodhart, Johan van Es, Wei Wu, Hans Clevers
Epidermal growth factor receptor (EGFR) is a target of the tumor-suppressor E3 ligase FBXW7. Proceedings of the National Academy of Sciences of the United States of America 121 (12) (2024)
Nicolas Alcala, Catherine Voegele, Lise Mangiante, Alexandra Sexton-Oates, Hans Clevers, Lynnette Fernandez-Cuesta, Talya L Dayton, Matthieu Foll
Multi-omic dataset of patient-derived tumor organoids of neuroendocrine neoplasms. GigaScience 13 (2024)
Matteo Boretto, Maarten H Geurts, Shashank Gandhi, Ziliang Ma, Nadzeya Staliarova, Martina Celotti, Sangho Lim, Gui-Wei He, Rosemary Millen, Else Driehuis, Harry Begthel, Lidwien Smabers, Jeanine Roodhart, Johan van Es, Wei Wu, Hans Clevers
Epidermal growth factor receptor (EGFR) is a target of the tumor-suppressor E3 ligase FBXW7. Proceedings of the National Academy of Sciences of the United States of America 121 (12) (2024)
Peter D Haughton, Wisse Haakma, Theofilos Chalkiadakis, Gerben E Breimer, Else Driehuis, Hans Clevers, Stefan Willems, Stefan Prekovic, Patrick W B Derksen
Differential transcriptional invasion signatures from patient derived organoid models define a functional prognostic tool for head and neck cancer. Oncogene (2024)
Gabriella S Darmasaputra, Cindy C Geerlings, Susana M Chuva de Sousa Lopes, Hans Clevers, Matilde Galli
Binucleated human hepatocytes arise through late cytokinetic regression during endomitosis M phase. The Journal of cell biology 223 (8) (2024)
Maria Alieva, Mario Barrera Román, Sam de Blank, Diana Petcu, Amber L Zeeman, Noël M M Dautzenberg, Annelisa M Cornel, Cesca van de Ven, Rob Pieters, Monique L Den Boer, Stefan Nierkens, Friso G J Calkoen, Hans Clevers, Jürgen Kuball, Zsolt Sebestyén, Ellen J Wehrens, Johanna F Dekkers, Anne C Rios
BEHAV3D: a 3D live imaging platform for comprehensive analysis of engineered T cell behavior and tumor response. Nature protocols 19 (7) (2024)
Delilah Hendriks, Benedetta Artegiani, Thanasis Margaritis, Iris Zoutendijk, Susana Chuva de Sousa Lopes, Hans Clevers
Mapping of mitogen and metabolic sensitivity in organoids defines requirements for human hepatocyte growth. Nature communications 15 (1) (2024)
Lin Lin, Hans Clevers
Decoding endocrine cell differentiation: insights from high-throughput CRISPR screening in human gut organoids. Clinical and translational medicine 14 (1) (2024)
Nicolas Alcala, Catherine Voegele, Lise Mangiante, Alexandra Sexton-Oates, Hans Clevers, Lynnette Fernandez-Cuesta, Talya L Dayton, Matthieu Foll
Multi-omic dataset of patient-derived tumor organoids of neuroendocrine neoplasms. GigaScience 13 (2024)
Lin Lin, Hans Clevers
Decoding endocrine cell differentiation: insights from high-throughput CRISPR screening in human gut organoids. Clinical and translational medicine 14 (1) (2024)
Gabriella S Darmasaputra, Cindy C Geerlings, Susana M Chuva de Sousa Lopes, Hans Clevers, Matilde Galli
Binucleated human hepatocytes arise through late cytokinetic regression during endomitosis M phase. The Journal of cell biology 223 (8) (2024)
Matteo Boretto, Maarten H Geurts, Shashank Gandhi, Ziliang Ma, Nadzeya Staliarova, Martina Celotti, Sangho Lim, Gui-Wei He, Rosemary Millen, Else Driehuis, Harry Begthel, Lidwien Smabers, Jeanine Roodhart, Johan van Es, Wei Wu, Hans Clevers
Epidermal growth factor receptor (EGFR) is a target of the tumor-suppressor E3 ligase FBXW7. Proceedings of the National Academy of Sciences of the United States of America 121 (12) (2024)
Gabriella S Darmasaputra, Cindy C Geerlings, Susana M Chuva de Sousa Lopes, Hans Clevers, Matilde Galli
Binucleated human hepatocytes arise through late cytokinetic regression during endomitosis M phase. The Journal of cell biology 223 (8) (2024)
Lin Lin, Hans Clevers
Decoding endocrine cell differentiation: insights from high-throughput CRISPR screening in human gut organoids. Clinical and translational medicine 14 (1) (2024)
Gabriella S Darmasaputra, Cindy C Geerlings, Susana M Chuva de Sousa Lopes, Hans Clevers, Matilde Galli
Binucleated human hepatocytes arise through late cytokinetic regression during endomitosis M phase. The Journal of cell biology 223 (8) (2024)
Maria Alieva, Mario Barrera Román, Sam de Blank, Diana Petcu, Amber L Zeeman, Noël M M Dautzenberg, Annelisa M Cornel, Cesca van de Ven, Rob Pieters, Monique L Den Boer, Stefan Nierkens, Friso G J Calkoen, Hans Clevers, Jürgen Kuball, Zsolt Sebestyén, Ellen J Wehrens, Johanna F Dekkers, Anne C Rios
BEHAV3D: a 3D live imaging platform for comprehensive analysis of engineered T cell behavior and tumor response. Nature protocols (2024)
Patricia Hernández-López, Eline van Diest, Peter Brazda, Sabine Heijhuurs, Angelo Meringa, Lauren Hoorens van Heyningen, Caterina Riillo, Caroline Schwenzel, Marina Zintchenko, Inez Johanna, Mara J T Nicolasen, Astrid Cleven, Thomas A Kluiver, Rosemary Millen, Jiali Zheng, Froso Karaiskaki, Trudy Straetemans, Hans Clevers, Remco de Bree, Hendrik G Stunnenberg, Weng Chuan Peng, Jeanine Roodhart, Susana Minguet, Zsolt Sebestyén, Dennis X Beringer, Jürgen H E Kuball
Dual targeting of cancer metabolome and stress antigens affects transcriptomic heterogeneity and efficacy of engineered T cells. Nature immunology (2023)
Laura Rüland, Francesco Andreatta, Simone Massalini, Susana Chuva de Sousa Lopes, Hans Clevers, Delilah Hendriks, Benedetta Artegiani
Organoid models of fibrolamellar carcinoma mutations reveal hepatocyte transdifferentiation through cooperative BAP1 and PRKAR2A loss. Nature communications 14 (1) (2023)
Annie S P Yang, Devanjali Dutta, Kai Kretzschmar, Delilah Hendriks, Jens Puschhof, Huili Hu, Kim E Boonekamp, Youri van Waardenburg, Susana M Chuva de Sousa Lopes, Geert-Jan van Gemert, Johannes H W de Wilt, Teun Bousema, Hans Clevers, Robert W Sauerwein
Development of Plasmodium falciparum liver-stages in hepatocytes derived from human fetal liver organoid cultures. Nature communications 14 (1) (2023)
Delilah Hendriks, Jos F Brouwers, Karien Hamer, Maarten H Geurts, Léa Luciana, Simone Massalini, Carmen López-Iglesias, Peter J Peters, Maria J Rodríguez-Colman, Susana M Chuva de Sousa Lopes, Benedetta Artegiani, Hans Clevers
Engineered human hepatocyte organoids enable CRISPR-based target discovery and drug screening for steatosis. Nature biotechnology (2023)
Marco Calafiore, Ya-Yuan Fu, Paola Vinci, Viktor Arnhold, Winston Y Chang, Suze A Jansen, Anastasiya Egorova, Shuichiro Takashima, Jason Kuttiyara, Takahiro Ito, Jonathan S Serody, Susumu Nakae, Heth R Turnquist, Johan van Es, Hans Clevers, Caroline A Lindemans, Bruce R Blazar, Alan M Hanash
A tissue-intrinsic IL-33/EGF circuit promotes epithelial regeneration after intestinal injury. Nature communications 14 (1) (2023)
Shuyi Ji, Li Feng, Zile Fu, Gaohua Wu, Yingcheng Wu, Youpei Lin, Dayun Lu, Yuanli Song, Peng Cui, Zijian Yang, Chen Sang, Guohe Song, Shangli Cai, Yuanchuang Li, Hanqing Lin, Shu Zhang, Xiaoying Wang, Shuangjian Qiu, Xiaoming Zhang, Guoqiang Hua, Junqiang Li, Jian Zhou, Zhi Dai, Xiang-Dong Wang, Li Ding, Pei Wang, Daming Gao, Bing Zhang, Henry Rodriguez, Jia Fan, Hans Clevers, Hu Zhou, Yi-Di Sun, Qiang Gao
Pharmaco-proteogenomic characterization of liver cancer organoids for precision oncology. Science translational medicine 15 (706) (2023)
Audrey Sporrij, Avik Choudhuri, Meera Prasad, Brejnev Muhire, Eva M Fast, Margot E Manning, Jodi D Weiss, Michelle Koh, Song Yang, Robert E Kingston, Michael Yevgeniy Tolstorukov, Hans Clevers, Leonard I Zon
PGE 2 alters chromatin through H2A.Z-variant enhancer nucleosome modification to promote hematopoietic stem cell fate. Proceedings of the National Academy of Sciences of the United States of America 120 (19) (2023)
Irene Paassen, Justin Williams, Carla Ríos Arceo, Femke C A Ringnalda, Kimberly Shea Mercer, Juliane L Buhl, Natalia Moreno, Aniello Federico, Niels E Franke, Mariette Kranendonk, Santhosh A Upadhyaya, Kornelius Kerl, Marc van de Wetering, Hans Clevers, Marcel Kool, Eelco W Hoving, Martine F Roussel, Jarno Drost
Atypical teratoid/rhabdoid tumoroids reveal subgroup-specific drug vulnerabilities. Oncogene (2023)
Maarten H Geurts, Shashank Gandhi, Matteo G Boretto, Ninouk Akkerman, Lucca L M Derks, Gijs J F van Son, Martina Celotti, Sarina Harshuk-Shabso, Flavia Peci, Harry Begthel, Delilah Hendriks, Paul Schürmann, Amanda Andersson-Rolf, Susana M Chuva de Sousa Lopes, Johan H van Es, Ruben van Boxtel, Hans Clevers
One-step generation of tumor models by base editor multiplexing in adult stem cell-derived organoids. Nature communications 14 (1) (2023)
Anna Pagliaro, Roxy Finger, Iris Zoutendijk, Saskia Bunschuh, Hans Clevers, Delilah Hendriks, Benedetta Artegiani
Temporal morphogen gradient-driven neural induction shapes single expanded neuroepithelium brain organoids with enhanced cortical identity. Nature communications 14 (1) (2023)
Lin Lin, Jeff DeMartino, Daisong Wang, Gijs J F van Son, Reinier van der Linden, Harry Begthel, Jeroen Korving, Amanda Andersson-Rolf, Stieneke van den Brink, Carmen Lopez-Iglesias, Willine J van de Wetering, Aleksandra Balwierz, Thanasis Margaritis, Marc van de Wetering, Peter J Peters, Jarno Drost, Johan H van Es, Hans Clevers
Unbiased transcription factor CRISPR screen identifies ZNF800 as master repressor of enteroendocrine differentiation. Science (New York, N.Y.) 382 (6669) (2023)
Lucía San Juan, Ana Freije, Natalia Sanz-Gómez, Beatriz Jiménez-Matías, Cayetano Pleguezuelos-Manzano, J Ramón Sanz, Ernesto de Diego, Sara Naranjo, Hans Clevers, Alberto Gandarillas
DNA damage triggers squamous metaplasia in human lung and mammary cells via mitotic checkpoints. Cell death discovery 9 (1) (2023)
Fjodor A Yousef Yengej, Jitske Jansen, Carola M E Ammerlaan, Emre Dilmen, Carla Pou Casellas, Rosalinde Masereeuw, Joost G Hoenderop, Bart Smeets, Maarten B Rookmaaker, Marianne Christina Verhaar, Hans Clevers
Tubuloid culture enables long-term expansion of functional human kidney tubule epithelium from iPSC-derived organoids. Proceedings of the National Academy of Sciences of the United States of America 120 (6) (2023)
Audrey Sporrij, Avik Choudhuri, Meera Prasad, Brejnev Muhire, Eva M Fast, Margot E Manning, Jodi D Weiss, Michelle Koh, Song Yang, Robert E Kingston, Michael Yevgeniy Tolstorukov, Hans Clevers, Leonard I Zon
PGE 2 alters chromatin through H2A.Z-variant enhancer nucleosome modification to promote hematopoietic stem cell fate. Proceedings of the National Academy of Sciences of the United States of America 120 (19) (2023)
Anna Urciuolo, Giovanni Giuseppe Giobbe, Yixiao Dong, Federica Michielin, Luca Brandolino, Michael Magnussen, Onelia Gagliano, Giulia Selmin, Valentina Scattolini, Paolo Raffa, Paola Caccin, Soichi Shibuya, Dominic Scaglioni, Xuechun Wang, Ju Qu, Marko Z Nikolić, Marco Montagner, Gabriel L Galea, Hans Clevers, Monica Giomo, Paolo de Coppi, Nicola Elvassore
Hydrogel-in-hydrogel live bioprinting for guidance and control of organoids and organotypic cultures. Nature communications 14 (1) (2023)
Audrey Sporrij, Avik Choudhuri, Meera Prasad, Brejnev Muhire, Eva M Fast, Margot E Manning, Jodi D Weiss, Michelle Koh, Song Yang, Robert E Kingston, Michael Yevgeniy Tolstorukov, Hans Clevers, Leonard I Zon
PGE 2 alters chromatin through H2A.Z-variant enhancer nucleosome modification to promote hematopoietic stem cell fate. Proceedings of the National Academy of Sciences of the United States of America 120 (19) (2023)
Audrey Sporrij, Avik Choudhuri, Meera Prasad, Brejnev Muhire, Eva M Fast, Margot E Manning, Jodi D Weiss, Michelle Koh, Song Yang, Robert E Kingston, Michael Yevgeniy Tolstorukov, Hans Clevers, Leonard I Zon
PGE 2 alters chromatin through H2A.Z-variant enhancer nucleosome modification to promote hematopoietic stem cell fate. Proceedings of the National Academy of Sciences of the United States of America 120 (19) (2023)
Audrey Sporrij, Avik Choudhuri, Meera Prasad, Brejnev Muhire, Eva M Fast, Margot E Manning, Jodi D Weiss, Michelle Koh, Song Yang, Robert E Kingston, Michael Yevgeniy Tolstorukov, Hans Clevers, Leonard I Zon
PGE 2 alters chromatin through H2A.Z-variant enhancer nucleosome modification to promote hematopoietic stem cell fate. Proceedings of the National Academy of Sciences of the United States of America 120 (19) (2023)
Fjodor A Yousef Yengej, Jitske Jansen, Carola M E Ammerlaan, Emre Dilmen, Carla Pou Casellas, Rosalinde Masereeuw, Joost G Hoenderop, Bart Smeets, Maarten B Rookmaaker, Marianne Christina Verhaar, Hans Clevers
Tubuloid culture enables long-term expansion of functional human kidney tubule epithelium from iPSC-derived organoids. Proceedings of the National Academy of Sciences of the United States of America 120 (6) (2023)
Fjodor A Yousef Yengej, Jitske Jansen, Carola M E Ammerlaan, Emre Dilmen, Carla Pou Casellas, Rosalinde Masereeuw, Joost G Hoenderop, Bart Smeets, Maarten B Rookmaaker, Marianne Christina Verhaar, Hans Clevers
Tubuloid culture enables long-term expansion of functional human kidney tubule epithelium from iPSC-derived organoids. Proceedings of the National Academy of Sciences of the United States of America 120 (6) (2023)
Fjodor A Yousef Yengej, Jitske Jansen, Carola M E Ammerlaan, Emre Dilmen, Carla Pou Casellas, Rosalinde Masereeuw, Joost G Hoenderop, Bart Smeets, Maarten B Rookmaaker, Marianne Christina Verhaar, Hans Clevers
Tubuloid culture enables long-term expansion of functional human kidney tubule epithelium from iPSC-derived organoids. Proceedings of the National Academy of Sciences of the United States of America 120 (6) (2023)
Lucía San Juan, Ana Freije, Natalia Sanz-Gómez, Beatriz Jiménez-Matías, Cayetano Pleguezuelos-Manzano, J Ramón Sanz, Ernesto de Diego, Sara Naranjo, Hans Clevers, Alberto Gandarillas
DNA damage triggers squamous metaplasia in human lung and mammary cells via mitotic checkpoints. Cell death discovery 9 (1) (2023)
Laura Rüland, Francesco Andreatta, Simone Massalini, Susana Chuva de Sousa Lopes, Hans Clevers, Delilah Hendriks, Benedetta Artegiani
Organoid models of fibrolamellar carcinoma mutations reveal hepatocyte transdifferentiation through cooperative BAP1 and PRKAR2A loss. Nature communications 14 (1) (2023)
Laura Rüland, Francesco Andreatta, Simone Massalini, Susana Chuva de Sousa Lopes, Hans Clevers, Delilah Hendriks, Benedetta Artegiani
Organoid models of fibrolamellar carcinoma mutations reveal hepatocyte transdifferentiation through cooperative BAP1 and PRKAR2A loss. Nature communications 14 (1) (2023)
Audrey Sporrij, Avik Choudhuri, Meera Prasad, Brejnev Muhire, Eva M Fast, Margot E Manning, Jodi D Weiss, Michelle Koh, Song Yang, Robert E Kingston, Michael Yevgeniy Tolstorukov, Hans Clevers, Leonard I Zon
PGE 2 alters chromatin through H2A.Z-variant enhancer nucleosome modification to promote hematopoietic stem cell fate. Proceedings of the National Academy of Sciences of the United States of America 120 (19) (2023)
Fjodor A Yousef Yengej, Jitske Jansen, Carola M E Ammerlaan, Emre Dilmen, Carla Pou Casellas, Rosalinde Masereeuw, Joost G Hoenderop, Bart Smeets, Maarten B Rookmaaker, Marianne Christina Verhaar, Hans Clevers
Tubuloid culture enables long-term expansion of functional human kidney tubule epithelium from iPSC-derived organoids. Proceedings of the National Academy of Sciences of the United States of America 120 (6) (2023)
Thomas Sell, Christian Klotz, Matthias M Fischer, Rosario Astaburuaga, Susanne M Krug, Jarno Drost, Hans Clevers, Christine Sers, Markus Morkel, Nils Blüthgen
Oncogenic signaling is coupled to colorectal cancer cell differentiation state. The Journal of cell biology 222 (6) (2023)
Xuan Zheng, Max A Betjes, Pascal Ender, Yvonne J Goos, Guizela Huelsz-Prince, Hans Clevers, Jeroen S van Zon, Sander J Tans
Organoid cell fate dynamics in space and time. Science advances 9 (33) (2023)
Lindy L Visser, Margit Bleijs, Thanasis Margaritis, Marc van de Wetering, Frank C P Holstege, Hans Clevers
Ewing sarcoma single-cell transcriptome analysis reveals functionally impaired antigen-presenting cells. Cancer research communications (2023)
Lucía San Juan, Ana Freije, Natalia Sanz-Gómez, Beatriz Jiménez-Matías, Cayetano Pleguezuelos-Manzano, J Ramón Sanz, Ernesto de Diego, Sara Naranjo, Hans Clevers, Alberto Gandarillas
DNA damage triggers squamous metaplasia in human lung and mammary cells via mitotic checkpoints. Cell death discovery 9 (1) (2023)
Audrey Sporrij, Avik Choudhuri, Meera Prasad, Brejnev Muhire, Eva M Fast, Margot E Manning, Jodi D Weiss, Michelle Koh, Song Yang, Robert E Kingston, Michael Yevgeniy Tolstorukov, Hans Clevers, Leonard I Zon
PGE 2 alters chromatin through H2A.Z-variant enhancer nucleosome modification to promote hematopoietic stem cell fate. Proceedings of the National Academy of Sciences of the United States of America 120 (19) (2023)
Cun Li, Jingjing Huang, Yifei Yu, Zhixin Wan, Man Chun Chiu, Xiaojuan Liu, Shuxin Zhang, Jian-Piao Cai, Hin Chu, Gang Li, Jasper Fuk-Woo Chan, Kelvin Kai Wang To, Zifeng Yang, Shibo Jiang, Kwok-Yung Yuen, Hans Clevers, Jie Zhou
Human airway and nasal organoids reveal escalating replicative fitness of SARS-CoV-2 emerging variants. Proceedings of the National Academy of Sciences of the United States of America 120 (17) (2023)
Laura Rüland, Francesco Andreatta, Simone Massalini, Susana Chuva de Sousa Lopes, Hans Clevers, Delilah Hendriks, Benedetta Artegiani
Organoid models of fibrolamellar carcinoma mutations reveal hepatocyte transdifferentiation through cooperative BAP1 and PRKAR2A loss. Nature communications 14 (1) (2023)
Lucía San Juan, Ana Freije, Natalia Sanz-Gómez, Beatriz Jiménez-Matías, Cayetano Pleguezuelos-Manzano, J Ramón Sanz, Ernesto de Diego, Sara Naranjo, Hans Clevers, Alberto Gandarillas
DNA damage triggers squamous metaplasia in human lung and mammary cells via mitotic checkpoints. Cell death discovery 9 (1) (2023)
Fjodor A Yousef Yengej, Jitske Jansen, Carola M E Ammerlaan, Emre Dilmen, Carla Pou Casellas, Rosalinde Masereeuw, Joost G Hoenderop, Bart Smeets, Maarten B Rookmaaker, Marianne Christina Verhaar, Hans Clevers
Tubuloid culture enables long-term expansion of functional human kidney tubule epithelium from iPSC-derived organoids. Proceedings of the National Academy of Sciences of the United States of America 120 (6) (2023)
Ernesto Rodriguez, Kelly Boelaars, Kari Brown, Katarina Madunić, Thomas van Ee, Frederike Dijk, Joanne Verheij, R J Eveline Li, Sjoerd T T Schetters, Laura L Meijer, Tessa Ya Sung Le Large, Else Driehuis, Hans Clevers, Sven C M Bruijns, Tom O'Toole, Sandra J van Vliet, Maarten F Bijlsma, Dana L E Vergoossen, Geert Kazemier, Elisa Giovannetti, Juan J Garcia-Vallejo, Yvette van Kooyk
Analysis of the glyco-code in pancreatic ductal adenocarcinoma identifies glycan-mediated immune regulatory circuits. Communications biology 5 (1) (2022)
Bram Herpers, Berina Eppink, Mark I James, Carme Cortina, Adrià Cañellas-Socias, Sylvia F Boj, Xavier Hernando-Momblona, Dominik Glodzik, Rob C Roovers, Marc van de Wetering, Carina Bartelink-Clements, Vanessa Zondag-van der Zande, Jara García Mateos, Kuan Yan, Lucia Salinaro, Abdul Basmeleh, Szabolcs Fatrai, David Maussang, Jeroen J Lammerts van Bueren, Irene Chicote, Garazi Serna, Laia Cabellos, Lorena Ramírez, Paolo G Nuciforo, Ramon Salazar, Cristina Santos, Alberto Villanueva, Camille Stephan-Otto Attolini, Elena Sancho, Hector G Palmer, Josep Tabernero, Michael R Stratton, John de Kruif, Ton Logtenberg, Hans Clevers, Leo S Price, Robert G J Vries, Eduard Batlle, Mark Throsby
Functional patient-derived organoid screenings identify MCLA-158 as a therapeutic EGFR × LGR5 bispecific antibody with efficacy in epithelial tumors. Nature cancer 3 (4) (2022)
Flavio Bonanini, Dorota Kurek, Sara Previdi, Arnaud Nicolas, Delilah Hendriks, Sander de Ruiter, Marine Meyer, Maria Clapés Cabrer, Roelof Dinkelberg, Silvia Bonilla García, Bart Kramer, Thomas Olivier, Huili Hu, Carmen López-Iglesias, Frederik Schavemaker, Erik Walinga, Devanjali Dutta, Karla Queiroz, Karel Domansky, Bob Ronden, Jos Joore, Henriette L Lanz, Peter J Peters, Sebastiaan J Trietsch, Hans Clevers, Paul Vulto
In vitro grafting of hepatic spheroids and organoids on a microfluidic vascular bed. Angiogenesis 25 (4) (2022)
Joep Beumer, Julia Bauzá-Martinez, Tim S Veth, Veerle Geurts, Charelle Boot, Hannah Gilliam-Vigh, Steen S Poulsen, Filip K Knop, Wei Wu, Hans Clevers
Mapping prohormone processing by proteases in human enteroendocrine cells using genetically engineered organoid models. Proceedings of the National Academy of Sciences of the United States of America 119 (46) (2022)
Jelte van der Vaart, Lynn Bosmans, Stijn F Sijbesma, Kèvin Knoops, Willine J van de Wetering, Henny G Otten, Harry Begthel, Inne H M Borel Rinkes, Jeroen Korving, Eef G W M Lentjes, Carmen Lopez-Iglesias, Peter J Peters, Hanneke M van Santen, Menno R Vriens, Hans Clevers
Adult mouse and human organoids derived from thyroid follicular cells and modeling of Graves' hyperthyroidism. Proceedings of the National Academy of Sciences of the United States of America 118 (51) (2022)
Marlies C Ludikhuize, Sira Gevers, Nguyen T B Nguyen, Maaike Meerlo, S Khadijeh Shafiei Roudbari, M Can Gulersonmez, Edwin C A Stigter, Jarno Drost, Hans Clevers, Boudewijn M T Burgering, Maria J Rodríguez Colman
Rewiring glucose metabolism improves 5-FU efficacy in p53-deficient/KRAS G12D glycolytic colorectal tumors. Communications biology 5 (1) (2022)
Man-Chun Chiu, Cun Li, Xiaojuan Liu, Yifei Yu, Jingjing Huang, Zhixin Wan, Ding Xiao, Hin Chu, Jian-Piao Cai, Biao Zhou, Ko-Yung Sit, Wing-Kuk Au, Kenneth Kak-Yuen Wong, Gang Li, Jasper Fuk-Woo Chan, Kelvin Kai Wang To, Zhiwei Chen, Shibo Jiang, Hans Clevers, Kwok-Yung Yuen, Jie Zhou
A bipotential organoid model of respiratory epithelium recapitulates high infectivity of SARS-CoV-2 Omicron variant. Cell discovery 8 (1) (2022)
Johanna F Dekkers, Maria Alieva, Astrid Cleven, Farid Keramati, Amber K L Wezenaar, Esmée J van Vliet, Jens Puschhof, Peter Brazda, Inez Johanna, Angelo D Meringa, Heggert G Rebel, Maj-Britt Buchholz, Mario Barrera Román, Amber L Zeeman, Sam de Blank, Domenico Fasci, Maarten H Geurts, Annelisa M Cornel, Else Driehuis, Rosemary Millen, Trudy Straetemans, Mara J T Nicolasen, Tineke Aarts-Riemens, Hendrikus C R Ariese, Hannah R Johnson, Ravian L van Ineveld, Froso Karaiskaki, Oded Kopper, Yotam E Bar-Ephraim, Kai Kretzschmar, Alexander M M Eggermont, Stefan Nierkens, Ellen J Wehrens, Hendrik G Stunnenberg, Hans Clevers, Jürgen H E Kuball, Zsolt Sebestyen, Anne C Rios
Uncovering the mode of action of engineered T cells in patient cancer organoids. Nature biotechnology (2022)
Evelyn S Hanemaaijer, Thanasis Margaritis, Karin Sanders, Frank L Bos, Tito Candelli, Hanin Al-Saati, Max M van Noesel, Friederike A G Meyer-Wentrup, Marc van de Wetering, Frank C P Holstege, Hans Clevers
Single-cell atlas of developing murine adrenal gland reveals relation of Schwann cell precursor signature to neuroblastoma phenotype. Proceedings of the National Academy of Sciences of the United States of America 118 (5) (2021)
Giovanni Giuseppe Giobbe, Francesco Bonfante, Brendan C Jones, Onelia Gagliano, Camilla Luni, Zambaiti Elisa, Silvia Perin, Cecilia Laterza, Georg A Busslinger, Hannah Stuart, Matteo Pagliari, Alessio Bortolami, Eva Mazzetto, Anna Manfredi, Chiara Colantuono, Lucio Di Filippo, Alessandro Filippo Pellegata, Valentina Panzarin, Nikhil Thapar, Vivian Sze Wing Li, Simon Eaton, Davide Cacchiarelli, Hans Clevers, Nicola Elvassore, Paolo de Coppi
SARS-CoV-2 infection and replication in human gastric organoids. Nature communications 12 (1) (2021)
Joep Beumer, Maarten H Geurts, Mart M Lamers, Jens Puschhof, Jingshu Zhang, Jelte van der Vaart, Anna Z Mykytyn, Tim I Breugem, Samra Riesebosch, Debby Schipper, Petra B van den Doel, Wim de Lau, Cayetano Pleguezuelos-Manzano, Georg A Busslinger, Bart L Haagmans, Hans Clevers
A CRISPR/Cas9 genetically engineered organoid biobank reveals essential host factors for coronaviruses. Nature communications 12 (1) (2021)
Linda Gijzen, Fjodor A Yousef Yengej, Frans Schutgens, Marianne K Vormann, Carola M E Ammerlaan, Arnaud Nicolas, Dorota Kurek, Paul Vulto, Maarten B Rookmaaker, Henriette L Lanz, Marianne Christina Verhaar, Hans Clevers
Culture and analysis of kidney tubuloids and perfused tubuloid cells-on-a-chip. Nature protocols 16 (4) (2021)
Michael VanInsberghe, Jeroen van den Berg, Amanda Andersson-Rolf, Hans Clevers, Alexander van Oudernaarden
Single-cell Ribo-seq reveals cell cycle-dependent translational pausing. Nature 597 (7877) (2021)
Robert Edward Hynds, William J Zacharias, Marko Z Nikolić, Melanie Königshoff, Oliver Eickelberg, Reinoud Gosens, Paolo de Coppi, Samuel M Janes, Edward E Morrisey, Hans Clevers, Amy L Ryan, Barry R Stripp, Xin Sun, Carla F Kim, Qing S Lin
National Heart, Lung, and Blood Institute and Building Respiratory Epithelium and Tissue for Health (BREATH) Consortium Workshop Report: Moving Forward in Lung Regeneration. American journal of respiratory cell and molecular biology 65 (1) (2021)
Jelte van der Vaart, Mart M Lamers, Bart L Haagmans, Hans Clevers
Advancing lung organoids for COVID-19 research. Disease models & mechanisms 14 (6) (2021)
Jelte van der Vaart, Lena Böttinger, Maarten H Geurts, Willine J van de Wetering, Kèvin Knoops, Norman Sachs, Harry Begthel, Jeroen Korving, Carmen Lopez-Iglesias, Peter J Peters, Kerem Eitan, Alex Gileles-Hillel, Hans Clevers
Modelling of primary ciliary dyskinesia using patient-derived airway organoids. EMBO reports 22 (12) (2021)
Yuezheng Zhang, Brendan F Kohrn, Ming Yang, Daniela Nachmanson, T Rinda Soong, I-Hsiu Lee, Yong Tao, Hans Clevers, Elizabeth M Swisher, Teresa A Brentnall, Lawrence A Loeb, Scott R Kennedy, Jesse J Salk, Kamila Naxerova, Rosa Ana Risques
PolyG-DS: An ultrasensitive polyguanine tract-profiling method to detect clonal expansions and trace cell lineage. Proceedings of the National Academy of Sciences of the United States of America 118 (31) (2021)
Amer Jamalpoor, Charlotte Agh van Gelder, Fjodor A Yousef Yengej, Esther A Zaal, Sante P Berlingerio, Koenraad R Veys, Carla Pou Casellas, Koen Voskuil, Khaled Essa, Carola Me Ammerlaan, Laura Rita Rega, Reini E N van der Welle, Marc R Lilien, Maarten B Rookmaaker, Hans Clevers, Judith Klumperman, Elena Levtchenko, Celia R Berkers, Marianne C Verhaar, A F Maarten Altelaar, Rosalinde Masereeuw, Manoe J Janssen
Cysteamine-bicalutamide combination therapy corrects proximal tubule phenotype in cystinosis. EMBO molecular medicine 13 (7) (2021)
Maarten H Geurts, Eyleen de Poel, Cayetano Pleguezuelos-Manzano, Rurika Oka, Léo Carrillo, Amanda Andersson-Rolf, Matteo Boretto, Jesse E Brunsveld, Ruben van Boxtel, Jeffrey M Beekman, Hans Clevers
Evaluating CRISPR-based prime editing for cancer modeling and CFTR repair in organoids. Life science alliance 4 (10) (2021)
Jens Puschhof, Yorick Post, Joep Beumer, Harald M Kerkkamp, Matyas Bittenbinder, Freek J Vonk, Nicholas R Casewell, Michael K Richardson, Hans Clevers
Derivation of snake venom gland organoids for in vitro venom production. Nature protocols 16 (3) (2021)
Jens Puschhof, Cayetano Pleguezuelos-Manzano, Adriana Martinez-Silgado, Ninouk Akkerman, Aurelia Saftien, Charelle Boot, Amy M de Waal, Joep Beumer, Devanjali Dutta, Inha Heo, Hans Clevers
Intestinal organoid cocultures with microbes. Nature protocols 16 (10) (2021)
Mart M Lamers, Jelte van der Vaart, Kèvin Knoops, Samra Riesebosch, Tim I Breugem, Anna Z Mykytyn, Joep Beumer, Debby Schipper, Karel Bezstarosti, Charlotte D Koopman, Nathalie Groen, Raimond B G Ravelli, Hans Q Duimel, Jeroen A A Demmers, Georges G M G M Verjans, Marion P G Koopmans, Mauro J Muraro, Peter J Peters, Hans Clevers, Bart L Haagmans
An organoid-derived bronchioalveolar model for SARS-CoV-2 infection of human alveolar type II-like cells. The EMBO journal 40 (5) (2021)
Nino Iakobachvili, Stephen Adonai Leon-Icaza, Kèvin Knoops, Norman Sachs, Serge Mazères, Roxane Simeone, Antonio Peixoto, Célia Bernard, Marlène Murris-Espin, Julien Mazieres, Kaymeuang Cam, Christian Chalut, Christophe Guilhot, Carmen López-Iglesias, Raimond B G Ravelli, Olivier Neyrolles, Etienne Meunier, Geanncarlo Lugo-Villarino, Hans Clevers, Céline Cougoule, Peter J Peters
Mycobacteria-host interactions in human bronchiolar airway organoids. Molecular microbiology (2021)
Johanna F Dekkers, Esmée J van Vliet, Norman Sachs, Jennifer M Rosenbluth, Oded Kopper, Heggert G Rebel, Ellen J Wehrens, Carol Piani, Jane E Visvader, Carla S Verissimo, Sylvia F Boj, Joan S Brugge, Hans Clevers, Anne C Rios
Long-term culture, genetic manipulation and xenotransplantation of human normal and breast cancer organoids. Nature protocols 16 (4) (2021)
Dustin J Flanagan, Nalle Pentinmikko, Kalle Luopajärvi, Nicky J Willis, Kathryn Gilroy, Alexander P Raven, Lynn McGarry, Johanna I Englund, Anna T Webb, Sandra Scharaw, Nadia Nasreddin, Michael C Hodder, Rachel A Ridgway, Emma Minnee, Nathalie Sphyris, Ella Gilchrist, Arafath K Najumudeen, Beatrice Romagnolo, Christine Perret, Ann Caroline Williams, Hans Clevers, Pirjo Nummela, Marianne Lähde, Kari Alitalo, Ville Hietakangas, Ann Hedley, William Clark, Colin Nixon, Kristina Kirschner, Edith Yvonne Jones, Ari Ristimäki, Simon J Leedham, Paul V Fish, Jean-Paul Vincent, Pekka Katajisto, Owen James Sansom
NOTUM from Apc-mutant cells biases clonal competition to initiate cancer. Nature 594 (7863) (2021)
Franka H van der Linden, Eike K Mahlandt, Janine J G Arts, Joep Beumer, Jens Puschhof, Saskia Madelon Ada de Man, Anna O Chertkova, Bas Ponsioen, Hans Clevers, Jaap Diederik van Buul, Marten Postma, Theodorus W J Gadella, Joachim Goedhart
A turquoise fluorescence lifetime-based biosensor for quantitative imaging of intracellular calcium. Nature communications 12 (1) (2021)
Morgane Le Rolle, Filippo Massa, Pam Siggers, Laurent Turchi, Agnès Loubat, Bon-Kyoung Koo, Hans Clevers, Andy Greenfield, Andreas Schedl, Marie-Christine Chaboissier, Anne Amandine Chassot
Arrest of WNT/β-catenin signaling enables the transition from pluripotent to differentiated germ cells in mouse ovaries. Proceedings of the National Academy of Sciences of the United States of America 118 (30) (2021)
Georg A Busslinger, Buys de Barbanson, Rurika Oka, Bas L A Weusten, Michiel de Maat, Richard van Hillegersberg, Lodewijk A A Brosens, Ruben van Boxtel, Alexander van Oudenaarden, Hans Clevers
Molecular characterization of Barrett's esophagus at single-cell resolution. Proceedings of the National Academy of Sciences of the United States of America 118 (47) (2021)
Jennifer M Rosenbluth, Ron C J Schackmann, G Kenneth Gray, Laura M Selfors, Carman Man-Chung Li, Mackenzie Boedicker, Hendrik J Kuiken, Andrea Richardson, Jane Brock, Judy Garber, Deborah Dillon, Norman Sachs, Hans Clevers, Joan S Brugge
Organoid cultures from normal and cancer-prone human breast tissues preserve complex epithelial lineages. Nature communications 11 (1) (2020)
Irene Caffa, Vanessa Spagnolo, Claudio Vernieri, Francesca Valdemarin, Pamela Becherini, Min Wei, Sebastian Brandhorst, Chiara Zucal, Else Driehuis, Lorenzo Ferrando, Francesco Piacente, Alberto Tagliafico, Michele Cilli, Luca Mastracci, Valerio G Vellone, Silvano Piazza, Anna Laura Cremonini, Raffaella Gradaschi, Carolina Mantero, Mario Passalacqua, Alberto Ballestrero, Gabriele Zoppoli, Michele Cea, Annalisa Arrighi, Patrizio Odetti, Fiammetta Monacelli, Giulia Salvadori, Salvatore Cortellino, Hans Clevers, Filippo De Braud, Samir G Sukkar, Alessandro Provenzani, Valter Daniel Longo, Alessio Nencioni
Author Correction: Fasting-mimicking diet and hormone therapy induce breast cancer regression. Nature (2020)
Cayetano Pleguezuelos-Manzano, Jens Puschhof, Axel Rosendahl Huber, Arne Van Hoeck, Henry M Wood, Jason Nomburg, Carino Gurjao, Freek Manders, Guillaume Dalmasso, Paul B Stege, Fernanda L Paganelli, Maarten H Geurts, Joep Beumer, Tomohiro Mizutani, Yi Miao, Reinier van der Linden, Stefan van der Elst, null null, K Christopher Garcia, Janetta Top, Rob J L Willems, Marios Giannakis, Richard Bonnet, Philip Quirke, Matthew L Meyerson, Edwin Cuppen, Ruben van Boxtel, Hans Clevers
Mutational signature in colorectal cancer caused by genotoxic pks+ E. coli. Nature 580 (7802) (2020)
Nikolaus Rajewsky, Geneviève Almouzni, Stanislaw A Gorski, Stein Aerts, Bjørt K Kragesteen, Michela G Bertero, Christoph Bock, Annelien L Bredenoord, Giacomo Cavalli, Susanna Chiocca, Hans Clevers, Bart De Strooper, Angelika Eggert, Jan Ellenberg, Xosé M Fernández, Marek Figlerowicz, Susan M Gasser, Norbert Hübner, Jørgen Kjems, Jürgen Arthur Knoblich, Grietje Krabbe, Peter Lichter, Sten Linnarsson, Jean-Christophe Marine, John C Marioni, Marc A Marti-Renom, Mihai M Netea, Dörthe Nickel, Marcelo Nollmann, Halina R Novak, Helen Parkinson, Stefano Piccolo, Inês Pinheiro, Ana Pombo, Christian Popp, Juan I Garaycoechea, Sergio Roman-Roman, Philip Rosenstiel, Joachim L Schultze, Oliver Stegle, Amos Tanay, Giuseppe Testa, Dimitris Thanos, Fabian Joachim Theis, Maria-Elena Torres-Padilla, Alfonso Valencia, Céline Vallot, Alexander van Oudernaarden, Marie Vidal, Thierry Voet, null null
LifeTime and improving European healthcare through cell-based interceptive medicine. Nature 587 (7834) (2020)
Mart M Lamers, Joep Beumer, Jelte van der Vaart, Kèvin Knoops, Jens Puschhof, Tim I Breugem, Raimond B G Ravelli, J Paul van Schayck, Anna Z Mykytyn, Hans Q Duimel, Elly van Donselaar, Samra Riesebosch, Helma J H Kuijpers, Debby Schipper, Willine J van de Wetering, Miranda de Graaf, Marion P G Koopmans, Edwin Cuppen, Peter J Peters, Bart L Haagmans, Hans Clevers
SARS-CoV-2 productively infects human gut enterocytes. Science (New York, N.Y.) 369 (6499) (2020)
Jelte van der Vaart, Hans Clevers
Airway organoids as models of human disease. Journal of internal medicine 289 (5) (2020)
Nico Battich, Joep Beumer, Buys Anton de Barbanson, Lenno Krenning, Chloé S Baron, Marvin E Tanenbaum, Hans Clevers, Alexander van Oudernaarden
Sequencing metabolically labeled transcripts in single cells reveals mRNA turnover strategies. Science (New York, N.Y.) 367 (6482) (2020)
Irene Caffa, Vanessa Spagnolo, Claudio Vernieri, Francesca Valdemarin, Pamela Becherini, Min Wei, Sebastian Brandhorst, Chiara Zucal, Else Driehuis, Lorenzo Ferrando, Francesco Piacente, Alberto Tagliafico, Michele Cilli, Luca Mastracci, Valerio G Vellone, Silvano Piazza, Anna Laura Cremonini, Raffaella Gradaschi, Carolina Mantero, Mario Passalacqua, Alberto Ballestrero, Gabriele Zoppoli, Michele Cea, Annalisa Arrighi, Patrizio Odetti, Fiammetta Monacelli, Giulia Salvadori, Salvatore Cortellino, Hans Clevers, Filippo De Braud, Samir G Sukkar, Alessandro Provenzani, Valter Daniel Longo, Alessio Nencioni
Fasting-mimicking diet and hormone therapy induce breast cancer regression. Nature 583 (7817) (2020)
Yong-Hee Cho, Eun Ji Ro, Jeong-Su Yoon, Tomohiro Mizutani, Dong-Woo Kang, Jong-Chan Park, Tae Il Kim, Hans Clevers, Kang-Yell Choi
5-FU promotes stemness of colorectal cancer via p53-mediated WNT/β-catenin pathway activation. Nature communications 11 (1) (2020)
Camilla Calandrini, Frans Schutgens, Rurika Oka, Thanasis Margaritis, Tito Candelli, Luka Mathijsen, Carola Ammerlaan, Ravian L van Ineveld, Sepide Derakhshan, Sanne de Haan, Emmy Dolman, Philip Lijnzaad, Lars Custers, Harry Begthel, Hindrik H D Kerstens, Lindy L Visser, Maarten Rookmaaker, Marianne Christina Verhaar, Godelieve A M Tytgat, Patrick Kemmeren, Ronald R de Krijger, Reem Al-Saadi, Kathy Pritchard-Jones, Marcel Kool, Anne C Rios, Marry M van den Heuvel-Eibrink, Jan J Molenaar, Ruben van Boxtel, Frank C P Holstege, Hans Clevers, Jarno Drost
An organoid biobank for childhood kidney cancers that captures disease and tissue heterogeneity. Nature communications 11 (1) (2020)
Delilah Hendriks, Benedetta Artegiani, Huili Hu, Susana Chuva de Sousa Lopes, Hans Clevers
Establishment of human fetal hepatocyte organoids and CRISPR-Cas9-based gene knockin and knockout in organoid cultures from human liver. Nature protocols 16 (1) (2020)
Joep Beumer, Hans Clevers
Cell fate specification and differentiation in the adult mammalian intestine. Nature reviews. Molecular cell biology 22 (1) (2020)
Kadi Lõhmussaar, Oded Kopper, Jeroen Korving, Harry Begthel, Celien P H Vreuls, Johan H van Es, Hans Clevers
Assessing the origin of high-grade serous ovarian cancer using CRISPR-modification of mouse organoids. Nature communications 11 (1) (2020)

Hans Clevers.css-eqlu8i{font-size:small;padding-left:4px;} (H Clevers)

Publication Activity (10 Years)

Top Topics

Top Venues

Hans Clevers (H Clevers)