Sheng-Yong Yang (Shengyong Yang)

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 44

Top Topics

Top Venues

Journal of medicinal chemistry

Journal of the American Chemical Society

Nature communications

Journal of chemical information and modeling

This page only lists publications with an associated author ORCID identifier.

Publications

Liang Xiong, Feng Li, Yinping Guo, Jian Zhang, Ke Xu, Zijie Xiong, Aiping Tong, Linli Li, Sheng-Yong Yang
Discovery of a Potent and Cell-Active Inhibitor of DNA 6mA Demethylase ALKBH1. Journal of the American Chemical Society 146 (10) (2024)
Liang Xiong, Feng Li, Yinping Guo, Jian Zhang, Ke Xu, Zijie Xiong, Aiping Tong, Linli Li, Sheng-Yong Yang
Discovery of a Potent and Cell-Active Inhibitor of DNA 6mA Demethylase ALKBH1. Journal of the American Chemical Society 146 (10) (2024)
Liang Xiong, Feng Li, Yinping Guo, Jian Zhang, Ke Xu, Zijie Xiong, Aiping Tong, Linli Li, Sheng-Yong Yang
Discovery of a Potent and Cell-Active Inhibitor of DNA 6mA Demethylase ALKBH1. Journal of the American Chemical Society 146 (10) (2024)
Feng Li, Liang Xiong, Jian Zhang, Yinping Guo, Ke Xu, Zijie Xiong, Yuyang Wang, Shanmian Ji, Aiping Tong, Linli Li, Sheng-Yong Yang
Structural Optimization and Structure-Activity Relationship of 1 H -Pyrazole-4-carboxylic Acid Derivatives as DNA 6mA Demethylase ALKBH1 Inhibitors and Their Antigastric Cancer Activity. Journal of medicinal chemistry (2024)
Liang Xiong, Feng Li, Yinping Guo, Jian Zhang, Ke Xu, Zijie Xiong, Aiping Tong, Linli Li, Sheng-Yong Yang
Discovery of a Potent and Cell-Active Inhibitor of DNA 6mA Demethylase ALKBH1. Journal of the American Chemical Society (2024)
Jinshan Nan, Jingming Liu, Guifeng Lin, Shanshan Zhang, An-Jie Xia, Pei Zhou, Yangli Zhou, Jiahao Zhang, Jinlong Zhao, Shiyu Zhang, Chong Huang, Yifei Wang, Qian Hu, Junxian Chen, Mingli Xiang, Xin Yang, Sheng-Yong Yang
Discovery of 4-(1,2,4-Oxadiazol-5-yl)azepan-2-one Derivatives as a New Class of Cannabinoid Type 2 Receptor Agonists for the Treatment of Inflammatory Pain. Journal of medicinal chemistry 66 (5) (2023)
Cong Li, Qian Zhang, Wenxin Huang, Lu-Yi Huang, Qing Long, Yuqin Lei, Da Jia, Sheng-Yong Yang, Yang Yang, Xia Zhang, Qingxiang Sun
Discovery of a Hidden Pocket beneath the NES Groove by Novel Noncovalent CRM1 Inhibitors. Journal of medicinal chemistry 66 (24) (2023)
Jinshan Nan, Jingming Liu, Guifeng Lin, Shanshan Zhang, An-Jie Xia, Pei Zhou, Yangli Zhou, Jiahao Zhang, Jinlong Zhao, Shiyu Zhang, Chong Huang, Yifei Wang, Qian Hu, Junxian Chen, Mingli Xiang, Xin Yang, Sheng-Yong Yang
Discovery of 4-(1,2,4-Oxadiazol-5-yl)azepan-2-one Derivatives as a New Class of Cannabinoid Type 2 Receptor Agonists for the Treatment of Inflammatory Pain. Journal of medicinal chemistry 66 (5) (2023)
Zheng Xu, Lulu Guo, Jingjing Yu, Siyuan Shen, Chao Wu, Weifeng Zhang, Chang Zhao, Yue Deng, Xiaowen Tian, Yuying Feng, Hanlin Hou, Lantian Su, Hongshuang Wang, Shuo Guo, Heli Wang, Kexin Wang, Peipei Chen, Jie Zhao, Xiaoyu Zhang, Xihao Yong, Lin Cheng, Lunxu Liu, Sheng-Yong Yang, Fan Yang, Xiaohui Wang, Xiao Yu, Yun-Fei Xu, Jin-Peng Sun, Wei Yan, Zhenhua Shao
Ligand recognition and G protein coupling of trace amine receptor TAAR1. Nature (2023)
Lei Tao, Yue Zhou, Xiangyu Pan, Yuan Luo, Jiahao Qiu, Xia Zhou, Zhiqian Chen, Yan Li, Lian Xu, Yang Zhou, Zeping Zuo, Chunqi Liu, Liang Wang, Xiaocong Liu, Xinyu Tian, Na Su, Zhengnan Yang, Yu Zhang, Kun Gou, Na Sang, Huan Liu, Jiao Zou, Yuzhou Xiao, Xi Zhong, Jing Xu, Xinyu Yang, Kai Xiao, Yanyang Liu, Sheng-Yong Yang, Yong Peng, Junhong Han, Xiao-Bo Cen, Yinglan Zhao
Repression of LSD1 potentiates homologous recombination-proficient ovarian cancer to PARP inhibitors through down-regulation of BRCA1/2 and RAD51. Nature communications 14 (1) (2023)
Jinshan Nan, Jingming Liu, Guifeng Lin, Shanshan Zhang, An-Jie Xia, Pei Zhou, Yangli Zhou, Jiahao Zhang, Jinlong Zhao, Shiyu Zhang, Chong Huang, Yifei Wang, Qian Hu, Junxian Chen, Mingli Xiang, Xin Yang, Sheng-Yong Yang
Discovery of 4-(1,2,4-Oxadiazol-5-yl)azepan-2-one Derivatives as a New Class of Cannabinoid Type 2 Receptor Agonists for the Treatment of Inflammatory Pain. Journal of medicinal chemistry (2023)
Guangyu Wang, Xiaohong Liu, Kai Wang, Yuanxu Gao, Gen Li, Daniel T Baptista-Hon, Xiaohong Helena Yang, Kanmin Xue, Wa Hou Tai, Zeyu Jiang, Linling Cheng, Manson Fok, Johnson Yiu-Nam Lau, Sheng-Yong Yang, Ligong Lu, Ping Zhang, Kang Zhang
Deep-learning-enabled protein-protein interaction analysis for prediction of SARS-CoV-2 infectivity and variant evolution. Nature medicine (2023)
Cong Li, Qian Zhang, Wenxin Huang, Lu-Yi Huang, Qing Long, Yuqin Lei, Da Jia, Sheng-Yong Yang, Yang Yang, Xia Zhang, Qingxiang Sun
Discovery of a Hidden Pocket beneath the NES Groove by Novel Noncovalent CRM1 Inhibitors. Journal of medicinal chemistry 66 (24) (2023)
Cong Li, Qian Zhang, Wenxin Huang, Lu-Yi Huang, Qing Long, Yuqin Lei, Da Jia, Sheng-Yong Yang, Yang Yang, Xia Zhang, Qingxiang Sun
Discovery of a Hidden Pocket beneath the NES Groove by Novel Noncovalent CRM1 Inhibitors. Journal of medicinal chemistry 66 (24) (2023)
Jinshan Nan, Jingming Liu, Guifeng Lin, Shanshan Zhang, An-Jie Xia, Pei Zhou, Yangli Zhou, Jiahao Zhang, Jinlong Zhao, Shiyu Zhang, Chong Huang, Yifei Wang, Qian Hu, Junxian Chen, Mingli Xiang, Xin Yang, Sheng-Yong Yang
Discovery of 4-(1,2,4-Oxadiazol-5-yl)azepan-2-one Derivatives as a New Class of Cannabinoid Type 2 Receptor Agonists for the Treatment of Inflammatory Pain. Journal of medicinal chemistry 66 (5) (2023)
Cong Li, Qian Zhang, Wenxin Huang, Lu-Yi Huang, Qing Long, Yuqin Lei, Da Jia, Sheng-Yong Yang, Yang Yang, Xia Zhang, Qingxiang Sun
Discovery of a Hidden Pocket beneath the NES Groove by Novel Noncovalent CRM1 Inhibitors. Journal of medicinal chemistry (2023)
Cong Li, Qian Zhang, Wenxin Huang, Lu-Yi Huang, Qing Long, Yuqin Lei, Da Jia, Sheng-Yong Yang, Yang Yang, Xia Zhang, Qingxiang Sun
Discovery of a Hidden Pocket beneath the NES Groove by Novel Noncovalent CRM1 Inhibitors. Journal of medicinal chemistry (2023)
Yue-Shan Li, Liting Zhang, Yi-Fei Wang, Jun Zou, Ruicheng Yang, Xinling Luo, Chengyong Wu, Wei Yang, Chenyu Tian, Haixing Xu, Falu Wang, Xin Yang, Linli Li, Sheng-Yong Yang
Generative deep learning enables the discovery of a potent and selective RIPK1 inhibitor. Nature communications 13 (1) (2022)
Shulei Pan, Liting Zhang, Xinling Luo, Jinshan Nan, Wei Yang, Huachao Bin, Yang Li, Qiao Huang, Tianqi Wang, Zhiling Pan, Bo Mu, Falu Wang, Chenyu Tian, Yang Liu, Linli Li, Sheng-Yong Yang
Structural Optimization and Structure-Activity Relationship Studies of 6,6-Dimethyl-4-(phenylamino)-6 H -pyrimido[5,4- b ][1,4]oxazin-7(8 H )-one Derivatives as A New Class of Potent Inhibitors of Pan-Trk and Their Drug-Resistant Mutants. Journal of medicinal chemistry 65 (3) (2022)
Xin Yang, Guifeng Lin, An-Jie Xia, Jingming Liu, Shiyu Zhang, Pei Zhou, Yiwei Wang, Jiahao Zhang, Yangli Zhou, Pei Chen, Yifei Wang, Tao Zheng, Linli Li, Sheng-Yong Yang
Discovery of Small Molecule Agonist of Gonadotropin-Releasing Hormone Receptor (GnRH1R). Journal of chemical information and modeling 62 (20) (2022)
Yue-Shan Li, Liting Zhang, Ruicheng Yang, Zeen Qiao, Ming Wu, Chong Huang, Chenyu Tian, Xinling Luo, Wei Yang, Yun Zhang, Linli Li, Sheng-Yong Yang
Discovery of 3,4-Dihydrobenzo[ f ][1,4]oxazepin-5(2 H )-one Derivatives as a New Class of Selective TNIK Inhibitors and Evaluation of Their Anti-Colorectal Cancer Effects. Journal of medicinal chemistry 65 (3) (2022)
Wei Yang, Bo Mu, Jing You, Chenyu Tian, Huachao Bin, Zhiqiang Xu, Liting Zhang, Ronggang Ma, Ming Wu, Guo Zhang, Chong Huang, Linli Li, Zhenhua Shao, Lunzhi Dai, Laurent Désaubry, Sheng-Yong Yang
Non-classical ferroptosis inhibition by a small molecule targeting PHB2. Nature communications 13 (1) (2022)
Bao-Xue Quan, Huiping Shuai, An-Jie Xia, Yuxin Hou, Rui Zeng, Xin-Lei Liu, Gui-Feng Lin, Jing-Xin Qiao, Wen-Pei Li, Fa-Lu Wang, Kai Wang, Ren-Jie Zhou, Terrence Tsz-Tai Yuen, Ming-Xin Chen, Chaemin Yoon, Ming Wu, Shi-Yu Zhang, Chong Huang, Yi-Fei Wang, Wei Yang, Chenyu Tian, Wei-Min Li, Yu-Quan Wei, Kwok-Yung Yuen, Jasper Fuk-Woo Chan, Jian Lei, Hin Chu, Sheng-Yong Yang
An orally available M pro inhibitor is effective against wild-type SARS-CoV-2 and variants including Omicron. Nature microbiology 7 (5) (2022)
Xin Yang, Xuehui Wang, Zheng Xu, Chao Wu, Yangli Zhou, Yi-Fei Wang, Guifeng Lin, Kan Li, Ming Wu, An-Jie Xia, Jingming Liu, Lin Cheng, Jun Zou, Wei Yan, Zhenhua Shao, Sheng-Yong Yang
Molecular mechanism of allosteric modulation for the cannabinoid receptor CB1. Nature chemical biology 18 (8) (2022)
Jingxin Qiao, Yue-Shan Li, Rui Zeng, Feng-Liang Liu, Rong-Hua Luo, Chong Huang, Yi-Fei Wang, Jie Zhang, Baoxue Quan, Chenjian Shen, Xin Mao, Xinlei Liu, Weining Sun, Wei Yang, Xincheng Ni, Kai Wang, Ling Xu, Zi-Lei Duan, Qing-Cui Zou, Hai-Lin Zhang, Wang Qu, Yang-Hao-Peng Long, Ming-Hua Li, Rui-Cheng Yang, Xiaolong Liu, Jing You, Yangli Zhou, Rui Yao, Wen-Pei Li, Jing-Ming Liu, Pei Chen, Yang Liu, Gui-Feng Lin, Xin Yang, Jun Zou, Linli Li, Yiguo Hu, Guang-Wen Lu, Wei-Min Li, Yu-Quan Wei, Yong-Tang Zheng, Jian Lei, Sheng-Yong Yang
SARS-CoV-2 Mpro inhibitors with antiviral activity in a transgenic mouse model. Science (New York, N.Y.) 371 (6536) (2021)
Yinping Guo, Xin Mao, Liang Xiong, Anjie Xia, Jing You, Guifeng Lin, Chengyong Wu, Luyi Huang, Yiwei Wang, Sheng-Yong Yang
Structure-Guided Discovery of a Potent and Selective Cell-Active Inhibitor of SETDB1 Tudor Domain. Angewandte Chemie (International ed. in English) 60 (16) (2021)
Xiuli Chen, Weining Sun, Shenzhen Huang, Hailin Zhang, Guifeng Lin, Hui Li, Jingxin Qiao, Linli Li, Sheng-Yong Yang
Discovery of Potent Small-Molecule SIRT6 Activators: Structure-Activity Relationship and Anti-Pancreatic Ductal Adenocarcinoma Activity. Journal of medicinal chemistry 63 (18) (2020)
Xin Yang, Yifei Wang, Ryan Byrne, Gisbert Schneider, Sheng-Yong Yang
Concepts of Artificial Intelligence for Computer-Assisted Drug Discovery. Chemical reviews 119 (18) (2019)
Xue Yuan, Yong Chen, Wanhua Zhang, Jun He, Lei Lei, Minghai Tang, Jiang Liu, Muzhou Li, Caixia Dou, Tao Yang, Linyu Yang, Sheng-Yong Yang, Yuquan Wei, Aihua Peng, Ting Niu, Mingli Xiang, Haoyu Ye, Li-Juan Chen
Identification of Pyrrolo[2,3- d]pyrimidine-Based Derivatives as Potent and Orally Effective Fms-like Tyrosine Receptor Kinase 3 (FLT3) Inhibitors for Treating Acute Myelogenous Leukemia. Journal of medicinal chemistry 62 (8) (2019)
Yong Chen, Xue Yuan, Wanhua Zhang, Minghai Tang, Li Zheng, Fang Wang, Wei Yan, Sheng-Yong Yang, Yuquan Wei, Jun He, Li-Juan Chen
Discovery of Novel Dual Histone Deacetylase and Mammalian Target of Rapamycin Target Inhibitors as a Promising Strategy for Cancer Therapy. Journal of medicinal chemistry 62 (3) (2019)
Xin Yang, Jun Zou, Yifei Wang, Ying Xue, Sheng-Yong Yang
Role of Water in the Reaction Mechanism and endo/exo Selectivity of 1,3-Dipolar Cycloadditions Elucidated by Quantum Chemistry and Machine Learning. Chemistry (Weinheim an der Bergstrasse, Germany) 25 (35) (2019)
Lanying Zhao, Yueshan Li, Yujiao Wang, Zeen Qiao, Zhuang Miao, Jiao Yang, Luyi Huang, Chenyu Tian, Linli Li, Danian Chen, Sheng-Yong Yang
Discovery of 4H-Chromen-4-one Derivatives as a New Class of Selective Rho Kinase (ROCK) Inhibitors, which Showed Potent Activity in ex Vivo Diabetic Retinopathy Models. Journal of medicinal chemistry 62 (23) (2019)
Liang Gong, Hong-Bao Sun, Li-Fan Deng, Xia Zhang, Jie Liu, Sheng-Yong Yang, Dawen Niu
Ni-Catalyzed Suzuki-Miyaura Cross-Coupling of α-Oxo-vinylsulfones To Prepare C-Aryl Glycals and Acyclic Vinyl Ethers. Journal of the American Chemical Society 141 (19) (2019)
Xuemeng Chen, Xue Xiao, Haotian Sun, Yue Li, Haolin Cao, Xuemei Zhang, Sheng-Yong Yang, Zhong Lian
Transition-Metal-Catalyzed Transformation of Sulfonates via S-O Bond Cleavage: Synthesis of Alkyl Aryl Ether and Diaryl Ether. Organic letters 21 (22) (2019)
Yueshan Li, Yu Xiong, Guo Zhang, Liting Zhang, Wei Yang, Jiao Yang, Luyi Huang, Zeen Qiao, Zhuang Miao, Guifeng Lin, Qiu Sun, Ting Niu, Li-Juan Chen, Dawen Niu, Linli Li, Sheng-Yong Yang
Correction to Identification of 5-(2,3-Dihydro-1 H-indol-5-yl)-7 H-pyrrolo[2,3- d]pyrimidin-4-amine Derivatives as a New Class of Receptor-Interacting Protein Kinase 1 (RIPK1) Inhibitors, Which Showed Potent Activity in a Tumor Metastasis Model. Journal of medicinal chemistry 62 (6) (2019)
Luyi Huang, Hui Li, Linli Li, Lu Niu, Raina Seupel, Chengyong Wu, Wei Cheng, Chong Chen, Bisen Ding, Paul E Brennan, Sheng-Yong Yang
Discovery of Pyrrolo[3,2- d]pyrimidin-4-one Derivatives as a New Class of Potent and Cell-Active Inhibitors of P300/CBP-Associated Factor Bromodomain. Journal of medicinal chemistry 62 (9) (2019)
Shenzhen Huang, Xiang Wang, Guifeng Lin, Jie Cheng, Xiuli Chen, Weining Sun, Rong Xiang, Yamei Yu, Linli Li, Sheng-Yong Yang
Discovery of human TyrRS inhibitors by structure-based virtual screening, structural optimization, and bioassays. RSC advances 9 (16) (2019)
Anjie Xia, Xueyu Qi, Xin Mao, Xiaoai Wu, Xin Yang, Rong Zhang, Zhiyu Xiang, Zhong Lian, Ying-Chun Chen, Sheng-Yong Yang
Metal-Free Aerobic Oxidative Selective C-C Bond Cleavage in Heteroaryl-Containing Primary and Secondary Alcohols. Organic letters 21 (9) (2019)
Qingxiang Guo, Chenhua Yu, Chao Zhang, Yongtao Li, Tianqi Wang, Zhi Huang, Xin Wang, Wei Zhou, Yao Li, Zhongxiang Qin, Cheng Wang, Ruifang Gao, Yongwei Nie, Yakun Ma, Yi Shi, Jianyu Zheng, Sheng-Yong Yang, Yan Fan, Rong Xiang
Highly Selective, Potent, and Oral mTOR Inhibitor for Treatment of Cancer as Autophagy Inducer. Journal of medicinal chemistry 61 (3) (2018)
Yongtao Li, Xiaohe Luo, Qingxiang Guo, Yongwei Nie, Tianqi Wang, Chao Zhang, Zhi Huang, Xin Wang, Yanhua Liu, Yanan Chen, Jianyu Zheng, Sheng-Yong Yang, Yan Fan, Rong Xiang
Discovery of N1-(4-((7-Cyclopentyl-6-(dimethylcarbamoyl)-7 H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)phenyl)- N8-hydroxyoctanediamide as a Novel Inhibitor Targeting Cyclin-dependent Kinase 4/9 (CDK4/9) and Histone Deacetlyase1 (HDAC1) against Malignant Cancer. Journal of medicinal chemistry 61 (7) (2018)
Yueshan Li, Yu Xiong, Guo Zhang, Liting Zhang, Wei Yang, Jiao Yang, Luyi Huang, Zeen Qiao, Zhuang Miao, Guifeng Lin, Qiu Sun, Ting Niu, Lijuan Chen, Dawen Niu, Linli Li, Sheng-Yong Yang
Identification of 5-(2,3-Dihydro-1 H-indol-5-yl)-7 H-pyrrolo[2,3- d]pyrimidin-4-amine Derivatives as a New Class of Receptor-Interacting Protein Kinase 1 (RIPK1) Inhibitors, Which Showed Potent Activity in a Tumor Metastasis Model. Journal of medicinal chemistry 61 (24) (2018)
Shenzhen Huang, Chunli Song, Xiang Wang, Guo Zhang, Yanlin Wang, Xiaojuan Jiang, Qizheng Sun, Luyi Huang, Rong Xiang, Yiguo Hu, Linli Li, Sheng-Yong Yang
Discovery of New SIRT2 Inhibitors by Utilizing a Consensus Docking/Scoring Strategy and Structure-Activity Relationship Analysis. Journal of chemical information and modeling 57 (4) (2017)
Guo-Bo Li, Zhu-Jun Yu, Sha Liu, Lu-Yi Huang, Ling-Ling Yang, Christopher T Lohans, Sheng-Yong Yang
IFPTarget: A Customized Virtual Target Identification Method Based on Protein-Ligand Interaction Fingerprinting Analyses. Journal of chemical information and modeling 57 (7) (2017)
Qi-Zheng Sun, Gui-Feng Lin, Lin-Li Li, Xi-Ting Jin, Lu-Yi Huang, Guo Zhang, Wei Yang, Kai Chen, Rong Xiang, Chong Chen, Yu-Quan Wei, Guang-Wen Lu, Sheng-Yong Yang
Discovery of Potent and Selective Inhibitors of Cdc2-Like Kinase 1 (CLK1) as a New Class of Autophagy Inducers. Journal of medicinal chemistry 60 (14) (2017)