Irina A Pikuleva (Irina Pikuleva)

Scopus Author ID Loop profile ORCID

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 31

Top Topics

Low Density Lipoprotein

Diabetic Retinopathy

Cognitive Decline

Top Venues

Cellular and molecular life sciences : CMLS

Brain : a journal of neurology

International journal of molecular sciences

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics

This page only lists publications with an associated author ORCID identifier.

Publications

Natalia Mast, Yong Li, Irina A Pikuleva
7,8-Dihydroxy Efavirenz Is Not as Effective in CYP46A1 Activation In Vivo as Efavirenz or Its 8,14-Dihydroxy Metabolite. International journal of molecular sciences 25 (4) (2024)
Hazem Ahmed, Yuqin Wang, William J Griffiths, Allan I Levey, Irina A Pikuleva, Steven H Liang, Ahmed Haider
Brain cholesterol and Alzheimer's disease: challenges and opportunities in probe and drug development. Brain : a journal of neurology (2024)
Hazem Ahmed, Yuqin Wang, William J Griffiths, Allan I Levey, Irina A Pikuleva, Steven H Liang, Ahmed Haider
Brain cholesterol and Alzheimer's disease: challenges and opportunities in probe and drug development. Brain : a journal of neurology 147 (5) (2024)
Nicole El-Darzi, Natalia Mast, Yong Li, Irina A Pikuleva
APOB100 transgenic mice exemplify how the systemic circulation content may affect the retina without altering retinal cholesterol input. Cellular and molecular life sciences : CMLS 81 (1) (2024)
Natalia Mast, Yong Li, Irina A Pikuleva
7,8-Dihydroxy Efavirenz Is Not as Effective in CYP46A1 Activation In Vivo as Efavirenz or Its 8,14-Dihydroxy Metabolite. International journal of molecular sciences 25 (4) (2024)
Nicole El-Darzi, Natalia Mast, Yong Li, Irina A Pikuleva
APOB100 transgenic mice exemplify how the systemic circulation content may affect the retina without altering retinal cholesterol input. Cellular and molecular life sciences : CMLS 81 (1) (2024)
Natalia Mast, Yong Li, Irina A Pikuleva
7,8-Dihydroxy Efavirenz Is Not as Effective in CYP46A1 Activation In Vivo as Efavirenz or Its 8,14-Dihydroxy Metabolite. International journal of molecular sciences 25 (4) (2024)
Natalia Mast, Yong Li, Irina A Pikuleva
7,8-Dihydroxy Efavirenz Is Not as Effective in CYP46A1 Activation In Vivo as Efavirenz or Its 8,14-Dihydroxy Metabolite. International journal of molecular sciences 25 (4) (2024)
Nicole El-Darzi, Natalia Mast, Yong Li, Irina A Pikuleva
APOB100 transgenic mice exemplify how the systemic circulation content may affect the retina without altering retinal cholesterol input. Cellular and molecular life sciences : CMLS 81 (1) (2024)
Nicole El-Darzi, Natalia Mast, Yong Li, Irina A Pikuleva
APOB100 transgenic mice exemplify how the systemic circulation content may affect the retina without altering retinal cholesterol input. Cellular and molecular life sciences : CMLS 81 (1) (2024)
Nicole El-Darzi, Natalia Mast, Yong Li, Irina A Pikuleva
APOB100 transgenic mice exemplify how the systemic circulation content may affect the retina without altering retinal cholesterol input. Cellular and molecular life sciences : CMLS 81 (1) (2024)
Hazem Ahmed, Yuqin Wang, William J Griffiths, Allan I Levey, Irina A Pikuleva, Steven H Liang, Ahmed Haider
Brain cholesterol and Alzheimer's disease: challenges and opportunities in probe and drug development. Brain : a journal of neurology (2024)
Nicole El-Darzi, Natalia Mast, Yong Li, Irina A Pikuleva
APOB100 transgenic mice exemplify how the systemic circulation content may affect the retina without altering retinal cholesterol input. Cellular and molecular life sciences : CMLS 81 (1) (2024)
Hazem Ahmed, Yuqin Wang, William J Griffiths, Allan I Levey, Irina A Pikuleva, Steven H Liang, Ahmed Haider
Brain cholesterol and Alzheimer's disease: challenges and opportunities in probe and drug development. Brain : a journal of neurology 147 (5) (2024)
Hazem Ahmed, Yuqin Wang, William J Griffiths, Allan I Levey, Irina A Pikuleva, Steven H Liang, Ahmed Haider
Brain cholesterol and Alzheimer's disease: challenges and opportunities in probe and drug development. Brain : a journal of neurology 147 (5) (2024)
Nicole El-Darzi, Natalia Mast, Yong Li, Brian Dailey, Min Kang, Douglas J Rhee, Irina A Pikuleva
The normalizing effects of the CYP46A1 activator efavirenz on retinal sterol levels and risk factors for glaucoma in Apoj -/- mice. Cellular and molecular life sciences : CMLS 80 (7) (2023)
Irina A Pikuleva
Challenges and opportunities in P450 research on the eye. Drug metabolism and disposition: the biological fate of chemicals (2023)
Nicole El-Darzi, Natalia Mast, Yong Li, Brian Dailey, Min Kang, Douglas J Rhee, Irina A Pikuleva
The normalizing effects of the CYP46A1 activator efavirenz on retinal sterol levels and risk factors for glaucoma in Apoj -/- mice. Cellular and molecular life sciences : CMLS 80 (7) (2023)
Natalia Mast, Yong Li, Irina A Pikuleva
Increased Acetylcholine Levels and Other Brain Effects in 5XFAD Mice after Treatment with 8,14-Dihydroxy Metabolite of Efavirenz. International journal of molecular sciences 23 (14) (2022)
Ahmed Haider, Chunyu Zhao, Lu Wang, Zhiwei Xiao, Jian Rong, Xiaotian Xia, Zhen Chen, Stefanie K Pfister, Natalia Mast, Eylan Yutuc, Jiahui Chen, Yin-Long Li, Tuo Shao, Geoffrey I Warnock, Alyaa Dawoud, Theresa R Connors, Derek H Oakley, Huiyi Wei, Jinghao Wang, Zhihua Zheng, Hao Xu, April T Davenport, James B Daunais, Richard S Van, Yihan Shao, Yuqin Wang, Ming-Rong Zhang, Christian Loewe, Irina A Pikuleva, Allan L Levey, William J Griffiths, Steven H Liang
Assessment of cholesterol homeostasis in the living human brain. Science translational medicine 14 (665) (2022)
Natalia Mast, Alexey M Petrov, Erin Prendergast, Ilya Bederman, Irina A Pikuleva
Brain Acetyl-CoA Production and Phosphorylation of Cytoskeletal Proteins Are Targets of CYP46A1 Activity Modulation and Altered Sterol Flux. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 18 (3) (2021)
Nicole El-Darzi, Natalia Mast, Brian Dailey, John Denker, Yong Li, Joseph Vance, Irina A Pikuleva
Characterizations of Hamster Retina as a Model for Studies of Retinal Cholesterol Homeostasis. Biology 10 (10) (2021)
Alexey M Petrov, Irina A Pikuleva
Cholesterol 24-Hydroxylation by CYP46A1: Benefits of Modulation for Brain Diseases. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 16 (3) (2020)
Eylan Yutuc, Roberto Angelini, Mark Baumert, Natalia Mast, Irina A Pikuleva, Jillian Newton, Malcolm R Clench, David O F Skibinski, Owain W Howell, Yuqin Wang, William J Griffiths
Localization of sterols and oxysterols in mouse brain reveals distinct spatial cholesterol metabolism. Proceedings of the National Academy of Sciences of the United States of America 117 (11) (2020)
Alexey M Petrov, Morrie Lam, Natalia Mast, Jean Moon, Yong Li, Erin Maxfield, Irina A Pikuleva
CYP46A1 Activation by Efavirenz Leads to Behavioral Improvement without Significant Changes in Amyloid Plaque Load in the Brain of 5XFAD Mice. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 16 (3) (2020)
Nicole El-Darzi, Natalia Mast, Alexey M Petrov, Irina A Pikuleva
2-Hydroxypropyl-β-cyclodextrin reduces retinal cholesterol in wild-type and Cyp27a1-/- Cyp46a1-/- mice with deficiency in the oxysterol production. British journal of pharmacology 178 (16) (2020)
Nicole El-Darzi, Natalia Mast, Alexey M Petrov, Tung Dao, Artem A Astafev, Aicha Saadane, Erin Prendergast, Emmy Schwarz, Ilya Bederman, Irina A Pikuleva
Studies of ApoD-/- and ApoD-/-ApoE-/- mice uncover the APOD significance for retinal metabolism, function, and status of chorioretinal blood vessels. Cellular and molecular life sciences : CMLS 78 (3) (2020)
Natalia Mast, Nicole El-Darzi, Alexey M Petrov, Young Li, Irina A Pikuleva
CYP46A1-dependent and independent effects of efavirenz treatment. Brain communications 2 (2) (2020)
Alexey M Petrov, Artem A Astafev, Natalia Mast, Aicha Saadane, Nicole El-Darzi, Irina A Pikuleva
The Interplay between Retinal Pathways of Cholesterol Output and Its Effects on Mouse Retina. Biomolecules 9 (12) (2019)
Natalia Mast, Peter Verwilst, Clayton J Wilkey, Frederick Peter Guengerich, Irina A Pikuleva
In Vitro Activation of Cytochrome P450 46A1 (CYP46A1) by Efavirenz-Related Compounds. Journal of medicinal chemistry 63 (12) (2019)
Natalia Mast, Joseph B Lin, Kyle W Anderson, Ingemar Bjorkhem, Irina A Pikuleva
Transcriptional and post-translational changes in the brain of mice deficient in cholesterol removal mediated by cytochrome P450 46A1 (CYP46A1). PloS one 12 (10) (2017)