James Brugarolas

ORCID

Publication Activity (10 Years)

Years Active: 2018-2024
Publications (10 Years): 38

Top Venues

Clinical cancer research : an official journal of the American Association for Cancer Research

Cancer research

Science advances

EMBO molecular medicine

University of Texas Southwestern Medical Center at Dallas

This page only lists publications with an associated author ORCID identifier.

Affiliation History

University of Texas Southwestern Medical Center at Dallas

United States

Professor :: Internal Medicine, Hematology-Oncology

Publications

James Brugarolas, Gregory Obara, Kathryn E Beckermann, Brian I Rini, Elaine T Lam, James Hamilton, Thomas Schluep, Min Yi, So C Wong, Zhongping Lily Mao, Erick Gamelin, Nizar M Tannir
A First-in-Human Phase 1 Study of a Tumor-Directed RNA-Interference Drug against HIF2α in Patients with Advanced Clear Cell Renal Cell Carcinoma. Clinical cancer research : an official journal of the American Association for Cancer Research 30 (11) (2024)
Dazhi Wang, Iqbal Mahmud, Vijay S Thakur, Sze Kiat Tan, Daniel G Isom, David B Lombard, Mark L Gonzalgo, Oleksandr N Kryvenko, Philip L Lorenzi, Vanina Toffessi Tcheuyap, James Brugarolas, Scott M Welford
GPR1 and CMKLR1 control lipid metabolism to support development of clear cell renal cell carcinoma. Cancer research (2024)
Matilde Simoni, Chiara Menegazzi, Cristina Fracassi, Claudia C Biffi, Francesca Genova, Nazario Pio Tenace, Roberta Lucianò, Andrea Raimondi, Carlo Tacchetti, James Brugarolas, Davide Mazza, Rosa Bernardi
PML restrains p53 activity and cellular senescence in clear cell renal cell carcinoma. EMBO molecular medicine 16 (6) (2024)
Dazhi Wang, Iqbal Mahmud, Vijay S Thakur, Sze Kiat Tan, Daniel G Isom, David B Lombard, Mark L Gonzalgo, Oleksandr N Kryvenko, Philip L Lorenzi, Vanina Toffessi Tcheuyap, James Brugarolas, Scott M Welford
GPR1 and CMKLR1 control lipid metabolism to support development of clear cell renal cell carcinoma. Cancer research (2024)
Matilde Simoni, Chiara Menegazzi, Cristina Fracassi, Claudia C Biffi, Francesca Genova, Nazario Pio Tenace, Roberta Lucianò, Andrea Raimondi, Carlo Tacchetti, James Brugarolas, Davide Mazza, Rosa Bernardi
PML restrains p53 activity and cellular senescence in clear cell renal cell carcinoma. EMBO molecular medicine 16 (6) (2024)
Dazhi Wang, Iqbal Mahmud, Vijay S Thakur, Sze Kiat Tan, Daniel G Isom, David B Lombard, Mark L Gonzalgo, Oleksandr N Kryvenko, Philip L Lorenzi, Vanina Toffessi Tcheuyap, James Brugarolas, Scott M Welford
GPR1 and CMKLR1 Control Lipid Metabolism to Support the Development of Clear Cell Renal Cell Carcinoma. Cancer research 84 (13) (2024)
Juan Yang, Ramesh Butti, Shannon Cohn, Vanina Toffessi Tcheuyap, Arijit Mal, Mylinh Nguyen, Christina Stevens, Alana Christie, Akhilesh Mishra, Yuanqing Ma, Jiwoong Kim, Robert Abraham, Payal Kapur, Robert E Hammer, James Brugarolas
Unconventional mechanism of action and resistance to rapalogs in renal cancer. Proceedings of the National Academy of Sciences of the United States of America 121 (25) (2024)
Juan Yang, Ramesh Butti, Shannon Cohn, Vanina Toffessi Tcheuyap, Arijit Mal, Mylinh Nguyen, Christina Stevens, Alana Christie, Akhilesh Mishra, Yuanqing Ma, Jiwoong Kim, Robert Abraham, Payal Kapur, Robert E Hammer, James Brugarolas
Unconventional mechanism of action and resistance to rapalogs in renal cancer. Proceedings of the National Academy of Sciences of the United States of America 121 (25) (2024)
Dazhi Wang, Iqbal Mahmud, Vijay S Thakur, Sze Kiat Tan, Daniel G Isom, David B Lombard, Mark L Gonzalgo, Oleksandr N Kryvenko, Philip L Lorenzi, Vanina Toffessi Tcheuyap, James Brugarolas, Scott M Welford
GPR1 and CMKLR1 Control Lipid Metabolism to Support the Development of Clear Cell Renal Cell Carcinoma. Cancer research 84 (13) (2024)
Matilde Simoni, Chiara Menegazzi, Cristina Fracassi, Claudia C Biffi, Francesca Genova, Nazario Pio Tenace, Roberta Lucianò, Andrea Raimondi, Carlo Tacchetti, James Brugarolas, Davide Mazza, Rosa Bernardi
PML restrains p53 activity and cellular senescence in clear cell renal cell carcinoma. EMBO molecular medicine 16 (6) (2024)
Matilde Simoni, Chiara Menegazzi, Cristina Fracassi, Claudia C Biffi, Francesca Genova, Nazario Pio Tenace, Roberta Lucianò, Andrea Raimondi, Carlo Tacchetti, James Brugarolas, Davide Mazza, Rosa Bernardi
PML restrains p53 activity and cellular senescence in clear cell renal cell carcinoma. EMBO molecular medicine (2024)
James Brugarolas, Gregory Obara, Kathryn E Beckermann, Brian I Rini, Elaine T Lam, James Hamilton, Thomas Schluep, Min Yi, So C Wong, Zhongping Lily Mao, Erick Gamelin, Nizar M Tannir
A First-in-Human Phase 1 Study of a Tumor-Directed RNA-Interference Drug against HIF2α in Patients with Advanced Clear Cell Renal Cell Carcinoma. Clinical cancer research : an official journal of the American Association for Cancer Research (2024)
James Brugarolas, Gregory Obara, Kathryn E Beckermann, Brian I Rini, Elaine T Lam, James Hamilton, Thomas Schluep, Min Yi, So C Wong, Zhongping Lily Mao, Erick Gamelin, Nizar M Tannir
A First-in-Human Phase 1 Study of a Tumor-Directed RNA-Interference Drug against HIF2α in Patients with Advanced Clear Cell Renal Cell Carcinoma. Clinical cancer research : an official journal of the American Association for Cancer Research (2024)
Dazhi Wang, Iqbal Mahmud, Vijay S Thakur, Sze Kiat Tan, Daniel G Isom, David B Lombard, Mark L Gonzalgo, Oleksandr N Kryvenko, Philip L Lorenzi, Vanina Toffessi Tcheuyap, James Brugarolas, Scott M Welford
GPR1 and CMKLR1 Control Lipid Metabolism to Support the Development of Clear Cell Renal Cell Carcinoma. Cancer research 84 (13) (2024)
Juan Yang, Ramesh Butti, Shannon Cohn, Vanina Toffessi Tcheuyap, Arijit Mal, Mylinh Nguyen, Christina Stevens, Alana Christie, Akhilesh Mishra, Yuanqing Ma, Jiwoong Kim, Robert Abraham, Payal Kapur, Robert E Hammer, James Brugarolas
Unconventional mechanism of action and resistance to rapalogs in renal cancer. Proceedings of the National Academy of Sciences of the United States of America 121 (25) (2024)
Dazhi Wang, Iqbal Mahmud, Vijay S Thakur, Sze Kiat Tan, Daniel G Isom, David B Lombard, Mark L Gonzalgo, Oleksandr N Kryvenko, Philip L Lorenzi, Vanina Toffessi Tcheuyap, James Brugarolas, Scott M Welford
GPR1 and CMKLR1 control lipid metabolism to support development of clear cell renal cell carcinoma. Cancer research (2024)
Dazhi Wang, Iqbal Mahmud, Vijay S Thakur, Sze Kiat Tan, Daniel G Isom, David B Lombard, Mark L Gonzalgo, Oleksandr N Kryvenko, Philip L Lorenzi, Vanina Toffessi Tcheuyap, James Brugarolas, Scott M Welford
GPR1 and CMKLR1 Control Lipid Metabolism to Support the Development of Clear Cell Renal Cell Carcinoma. Cancer research 84 (13) (2024)
James Brugarolas, Gregory Obara, Kathryn E Beckermann, Brian I Rini, Elaine T Lam, James Hamilton, Thomas Schluep, Min Yi, So C Wong, Zhongping Lily Mao, Erick Gamelin, Nizar M Tannir
A First-in-Human Phase 1 Study of a Tumor-Directed RNA-Interference Drug against HIF2α in Patients with Advanced Clear Cell Renal Cell Carcinoma. Clinical cancer research : an official journal of the American Association for Cancer Research 30 (11) (2024)
James Brugarolas, Gregory Obara, Kathryn E Beckermann, Brian I Rini, Elaine T Lam, James Hamilton, Thomas Schluep, Min Yi, So C Wong, Zhongping Lily Mao, Erick Gamelin, Nizar M Tannir
A First-in-Human Phase 1 Study of a Tumor-Directed RNA-Interference Drug against HIF2α in Patients with Advanced Clear Cell Renal Cell Carcinoma. Clinical cancer research : an official journal of the American Association for Cancer Research 30 (11) (2024)
James Brugarolas, Gregory Obara, Kathryn E Beckermann, Brian I Rini, Elaine T Lam, James Hamilton, Thomas Schluep, Min Yi, So C Wong, Zhongping Lily Mao, Erick Gamelin, Nizar M Tannir
A First-in-Human Phase 1 Study of a Tumor-Directed RNA-Interference Drug against HIF2α in Patients with Advanced Clear Cell Renal Cell Carcinoma. Clinical cancer research : an official journal of the American Association for Cancer Research 30 (11) (2024)
Matilde Simoni, Chiara Menegazzi, Cristina Fracassi, Claudia C Biffi, Francesca Genova, Nazario Pio Tenace, Roberta Lucianò, Andrea Raimondi, Carlo Tacchetti, James Brugarolas, Davide Mazza, Rosa Bernardi
PML restrains p53 activity and cellular senescence in clear cell renal cell carcinoma. EMBO molecular medicine 16 (6) (2024)
Akash K Kaushik, Amy Tarangelo, Lindsey K Boroughs, Mukundan Ragavan, Yuanyuan Zhang, Cheng-Yang Wu, Xiangyi Li, Kristen Ahumada, Jui-Chung Chiang, Vanina Toffessi Tcheuyap, Faeze Saatchi, Quyen N Do, Cissy Yong, Tracy Rosales, Christina Stevens, Aparna D Rao, Brandon Faubert, Panayotis Pachnis, Lauren G Zacharias, Hieu Vu, Feng Cai, Thomas P Mathews, Giannicola Genovese, Barbara S Slusher, Payal Kapur, Xiankai Sun, Matthew E Merritt, James Brugarolas, Ralph J DeBerardinis
In vivo characterization of glutamine metabolism identifies therapeutic targets in clear cell renal cell carcinoma. Science advances 8 (50) (2022)
Chen Yao, Tian Zhang, Tuoqi Wu, James Brugarolas
Facts and Hopes for Immunotherapy in Renal Cell Carcinoma. Clinical cancer research : an official journal of the American Association for Cancer Research 28 (23) (2022)
Akash K Kaushik, Amy Tarangelo, Lindsey K Boroughs, Mukundan Ragavan, Yuanyuan Zhang, Cheng-Yang Wu, Xiangyi Li, Kristen Ahumada, Jui-Chung Chiang, Vanina Toffessi Tcheuyap, Faeze Saatchi, Quyen N Do, Cissy Yong, Tracy Rosales, Christina Stevens, Aparna D Rao, Brandon Faubert, Panayotis Pachnis, Lauren G Zacharias, Hieu Vu, Feng Cai, Thomas P Mathews, Giannicola Genovese, Barbara S Slusher, Payal Kapur, Xiankai Sun, Matthew E Merritt, James Brugarolas, Ralph J DeBerardinis
In vivo characterization of glutamine metabolism identifies therapeutic targets in clear cell renal cell carcinoma. Science advances 8 (50) (2022)
Yuanqing Ma, Allison Joyce, Olivia Brandenburg, Faeze Saatchi, Christina Stevens, Vanina Toffessi Tcheuyap, Alana Christie, Quyen N Do, Oluwatomilade Fatunde, Alyssa Macchiaroli, So C Wong, Layton Woolford, Qurratulain Yousuf, Jeffrey Miyata, Deyssy Carrillo, Oreoluwa Onabolu, Tiffani McKenzie, Akhilesh Mishra, Tanner Hardy, Wei He, Daniel Li, Alexander Ivanishev, Yang Zhang, Ivan Pedrosa, Payal Kapur, Thomas Schluep, Steven B Kanner, James Hamilton, James Brugarolas
HIF2 inactivation and tumor suppression with a tumor-directed RNA-silencing drug in mice and humans. Clinical cancer research : an official journal of the American Association for Cancer Research (2022)
Paul H Acosta, Vandana Panwar, Vipul Jarmale, Alana Christie, Jay Jasti, Vitaly Margulis, Dinesh Rakheja, John Cheville, Bradley C Leibovich, Alexander Parker, James Brugarolas, Payal Kapur, Satwik Rajaram
Intratumoral Resolution of Driver Gene Mutation Heterogeneity in Renal Cancer Using Deep Learning. Cancer research 82 (15) (2022)
Akash K Kaushik, Amy Tarangelo, Lindsey K Boroughs, Mukundan Ragavan, Yuanyuan Zhang, Cheng-Yang Wu, Xiangyi Li, Kristen Ahumada, Jui-Chung Chiang, Vanina Toffessi Tcheuyap, Faeze Saatchi, Quyen N Do, Cissy Yong, Tracy Rosales, Christina Stevens, Aparna D Rao, Brandon Faubert, Panayotis Pachnis, Lauren G Zacharias, Hieu Vu, Feng Cai, Thomas P Mathews, Giannicola Genovese, Barbara S Slusher, Payal Kapur, Xiankai Sun, Matthew E Merritt, James Brugarolas, Ralph J DeBerardinis
In vivo characterization of glutamine metabolism identifies therapeutic targets in clear cell renal cell carcinoma. Science advances 8 (50) (2022)
Akash K Kaushik, Amy Tarangelo, Lindsey K Boroughs, Mukundan Ragavan, Yuanyuan Zhang, Cheng-Yang Wu, Xiangyi Li, Kristen Ahumada, Jui-Chung Chiang, Vanina Toffessi Tcheuyap, Faeze Saatchi, Quyen N Do, Cissy Yong, Tracy Rosales, Christina Stevens, Aparna D Rao, Brandon Faubert, Panayotis Pachnis, Lauren G Zacharias, Hieu Vu, Feng Cai, Thomas P Mathews, Giannicola Genovese, Barbara S Slusher, Payal Kapur, Xiankai Sun, Matthew E Merritt, James Brugarolas, Ralph J DeBerardinis
In vivo characterization of glutamine metabolism identifies therapeutic targets in clear cell renal cell carcinoma. Science advances 8 (50) (2022)
Akash K Kaushik, Amy Tarangelo, Lindsey K Boroughs, Mukundan Ragavan, Yuanyuan Zhang, Cheng-Yang Wu, Xiangyi Li, Kristen Ahumada, Jui-Chung Chiang, Vanina Toffessi Tcheuyap, Faeze Saatchi, Quyen N Do, Cissy Yong, Tracy Rosales, Christina Stevens, Aparna D Rao, Brandon Faubert, Panayotis Pachnis, Lauren G Zacharias, Hieu Vu, Feng Cai, Thomas P Mathews, Giannicola Genovese, Barbara S Slusher, Payal Kapur, Xiankai Sun, Matthew E Merritt, James Brugarolas, Ralph J DeBerardinis
In vivo characterization of glutamine metabolism identifies therapeutic targets in clear cell renal cell carcinoma. Science advances 8 (50) (2022)
Akash K Kaushik, Amy Tarangelo, Lindsey K Boroughs, Mukundan Ragavan, Yuanyuan Zhang, Cheng-Yang Wu, Xiangyi Li, Kristen Ahumada, Jui-Chung Chiang, Vanina Toffessi Tcheuyap, Faeze Saatchi, Quyen N Do, Cissy Yong, Tracy Rosales, Christina Stevens, Aparna D Rao, Brandon Faubert, Panayotis Pachnis, Lauren G Zacharias, Hieu Vu, Feng Cai, Thomas P Mathews, Giannicola Genovese, Barbara S Slusher, Payal Kapur, Xiankai Sun, Matthew E Merritt, James Brugarolas, Ralph J DeBerardinis
In vivo characterization of glutamine metabolism identifies therapeutic targets in clear cell renal cell carcinoma. Science advances 8 (50) (2022)
Kangsan Kim, Huocong Huang, Pravat Kumar Parida, Lan He, Mauricio Marquez-Palencia, Tanner C Reese, Payal Kapur, James Brugarolas, Rolf A Brekken, Srinivas Malladi
Cell Competition Shapes Metastatic Latency and Relapse. Cancer discovery (2022)
Akash K Kaushik, Amy Tarangelo, Lindsey K Boroughs, Mukundan Ragavan, Yuanyuan Zhang, Cheng-Yang Wu, Xiangyi Li, Kristen Ahumada, Jui-Chung Chiang, Vanina Toffessi Tcheuyap, Faeze Saatchi, Quyen N Do, Cissy Yong, Tracy Rosales, Christina Stevens, Aparna D Rao, Brandon Faubert, Panayotis Pachnis, Lauren G Zacharias, Hieu Vu, Feng Cai, Thomas P Mathews, Giannicola Genovese, Barbara S Slusher, Payal Kapur, Xiankai Sun, Matthew E Merritt, James Brugarolas, Ralph J DeBerardinis
In vivo characterization of glutamine metabolism identifies therapeutic targets in clear cell renal cell carcinoma. Science advances 8 (50) (2022)
Aditi Mulgaonkar, Roy Elias, Layton Woolford, Bing Guan, Kien Nham, Payal Kapur, Alana Christie, Vanina Toffessi Tcheuyap, Nirmish Singla, Isaac Alex Bowman, Christina Stevens, Guiyang Hao, James Brugarolas, Xiankai Sun
ImmunoPET Imaging with 89Zr-Labeled Atezolizumab Enables In Vivo Evaluation of PD-L1 in Tumorgraft Models of Renal Cell Carcinoma. Clinical cancer research : an official journal of the American Association for Cancer Research 28 (22) (2022)
Daria Beshnova, Jianfeng Ye, Oreoluwa Onabolu, Benjamin Moon, Wenxin Zheng, Yang-Xin Fu, James Brugarolas, Jayanthi Lea, Bo Li
De novo prediction of cancer-associated T cell receptors for noninvasive cancer detection. Science translational medicine 12 (557) (2021)
Payal Kapur, Ming Gao, Hua Zhong, Suneetha Chintalapati, Midori Mitui, Spencer D Barnes, Qinbo Zhou, Jeffrey Miyata, Deyssy Carrillo, Venkat S Malladi, Dinesh Rakheja, Ivan Pedrosa, Lin Xu, Lisa Kinch, James Brugarolas
Germline and sporadic mTOR pathway mutations in low-grade oncocytic tumor of the kidney. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc (2021)
Viral Patel, Roy Elias, Joseph Formella, William Schwartzman, Alana Christie, Qi Cai, Venkat S Malladi, Payal Kapur, Miguel Vazquez, Renee McKay, Ivan Pedrosa, Raquibul Hannan, Hans Hammers, James Brugarolas
Acute interstitial nephritis, a potential predictor of response to immune checkpoint inhibitors in renal cell carcinoma. Journal for immunotherapy of cancer 8 (2) (2021)
Kangsan Kim, Qinbo Zhou, Alana Christie, Christina Stevens, Yuanqing Ma, Oreoluwa Onabolu, Suneetha Chintalapati, Tiffani Mckenzie, Vanina Toffessi Tcheuyap, Layton Woolford, He Zhang, Nirmish Singla, Pravat Kumar Parida, Mauricio Marquez-Palencia, Ivan Pedrosa, Vitaly Margulis, Arthur Sagalowsky, Zhiqun Xie, Tao Wang, Steffen Durinck, Zora Modrusan, Somasekar Seshagiri, Payal Kapur, James Brugarolas, Srinivas Malladi
Determinants of renal cell carcinoma invasion and metastatic competence. Nature communications 12 (1) (2021)
Rosa Puertollano, Shawn M Ferguson, James Brugarolas, Andrea Balabio
The complex relationship between TFEB transcription factor phosphorylation and subcellular localization. The EMBO journal 37 (11) (2018)

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Publication Activity (10 Years)

Top Topics

Top Venues

James Brugarolas