Barbara S Slusher

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 78

Top Topics

Peripheral Nerve

Neuropathic Pain

Top Venues

ACS chemical neuroscience

Journal of medicinal chemistry

Science advances

bioRxiv : the preprint server for biology

This page only lists publications with an associated author ORCID identifier.

Publications

Alessandro Bonifazi, Michael Ellenberger, Zachary J Farino, Despoina Aslanoglou, Rana Rais, Sandra Pereira, José O Mantilla-Rivas, Comfort A Boateng, Amy J Eshleman, Aaron Janowsky, Margaret K Hahn, Gary J Schwartz, Barbara S Slusher, Amy Hauck Newman, Zachary Z Freyberg
Development of novel tools for dissection of central versus peripheral dopamine D 2 -like receptor signaling in dysglycemia. bioRxiv : the preprint server for biology (2024)
Louis G Mueller, Barbara S Slusher, Takashi Tsukamoto
Empirical Analysis of Drug Targets for Nervous System Disorders. ACS chemical neuroscience 15 (3) (2024)
Louis G Mueller, Barbara S Slusher, Takashi Tsukamoto
Empirical Analysis of Drug Targets for Nervous System Disorders. ACS chemical neuroscience 15 (3) (2024)
Louis G Mueller, Barbara S Slusher, Takashi Tsukamoto
Empirical Analysis of Drug Targets for Nervous System Disorders. ACS chemical neuroscience 15 (3) (2024)
Yu Su, Meixiang Huang, Ajit G Thomas, John Maragakis, Kaitlyn D J Huizar, Yuxin Zheng, Ying Wu, Mohamed H Farah, Barbara S Slusher
GCPII Inhibition Promotes Remyelination after Peripheral Nerve Injury in Aged Mice. International journal of molecular sciences 25 (13) (2024)
Louis G Mueller, Barbara S Slusher, Takashi Tsukamoto
Empirical Analysis of Drug Targets for Nervous System Disorders. ACS chemical neuroscience 15 (3) (2024)
Monali Praharaj, Fan Shen, Alex J Lee, Liang Zhao, Thomas R Nirschl, Debebe Theodros, Alok K Singh, Xiaoxu Wang, Kenneth M Adusei, Kara A Lombardo, Raekwon A Williams, Laura A Sena, Elizabeth A Thompson, Ada J Tam, Srinivasan Yegnasubramanian, Edward J Pearce, Robert D Leone, Jesse Alt, Rana Rais, Barbara S Slusher, Drew M Pardoll, Jonathan D Powell, Jelani C Zarif
Metabolic Reprogramming of Tumor-Associated Macrophages Using Glutamine Antagonist JHU083 Drives Tumor Immunity in Myeloid-Rich Prostate and Bladder Cancers. Cancer immunology research 12 (7) (2024)
Alessandro Bonifazi, Michael Ellenberger, Zachary J Farino, Despoina Aslanoglou, Rana Rais, Sandra Pereira, José O Mantilla-Rivas, Comfort A Boateng, Amy J Eshleman, Aaron Janowsky, Margaret K Hahn, Gary J Schwartz, Barbara S Slusher, Amy Hauck Newman, Zachary Z Freyberg
Development of novel tools for dissection of central versus peripheral dopamine D 2 -like receptor signaling in dysglycemia. bioRxiv : the preprint server for biology (2024)
Alessandro Bonifazi, Michael Ellenberger, Zachary J Farino, Despoina Aslanoglou, Rana Rais, Sandra Pereira, José O Mantilla-Rivas, Comfort A Boateng, Amy J Eshleman, Aaron Janowsky, Margaret K Hahn, Gary J Schwartz, Barbara S Slusher, Amy Hauck Newman, Zachary Z Freyberg
Development of novel tools for dissection of central versus peripheral dopamine D 2 -like receptor signaling in dysglycemia. bioRxiv : the preprint server for biology (2024)
Yu Su, Meixiang Huang, Ajit G Thomas, John Maragakis, Kaitlyn D J Huizar, Yuxin Zheng, Ying Wu, Mohamed H Farah, Barbara S Slusher
GCPII Inhibition Promotes Remyelination after Peripheral Nerve Injury in Aged Mice. International journal of molecular sciences 25 (13) (2024)
Monali Praharaj, Fan Shen, Alex J Lee, Liang Zhao, Thomas R Nirschl, Debebe Theodros, Alok K Singh, Xiaoxu Wang, Kenneth M Adusei, Kara A Lombardo, Raekwon A Williams, Laura A Sena, Elizabeth A Thompson, Ada J Tam, Srinivasan Yegnasubramanian, Edward J Pearce, Robert D Leone, Jesse Alt, Rana Rais, Barbara S Slusher, Drew M Pardoll, Jonathan D Powell, Jelani C Zarif
Metabolic Reprogramming of Tumor-Associated Macrophages Using Glutamine Antagonist JHU083 Drives Tumor Immunity in Myeloid-Rich Prostate and Bladder Cancers. Cancer immunology research 12 (7) (2024)
Louis G Mueller, Barbara S Slusher, Takashi Tsukamoto
Empirical Analysis of Drug Targets for Nervous System Disorders. ACS chemical neuroscience 15 (3) (2024)
Alessandro Bonifazi, Michael Ellenberger, Zachary J Farino, Despoina Aslanoglou, Rana Rais, Sandra Pereira, José O Mantilla-Rivas, Comfort A Boateng, Amy J Eshleman, Aaron Janowsky, Margaret K Hahn, Gary J Schwartz, Barbara S Slusher, Amy Hauck Newman, Zachary Z Freyberg
Development of novel tools for dissection of central versus peripheral dopamine D 2 -like receptor signaling in dysglycemia. bioRxiv : the preprint server for biology (2024)
Monali Praharaj, Fan Shen, Alex J Lee, Liang Zhao, Thomas R Nirschl, Debebe Theodros, Alok K Singh, Xiaoxu Wang, Kenneth M Adusei, Kara A Lombardo, Raekwon A Williams, Laura A Sena, Elizabeth A Thompson, Ada J Tam, Srinivasan Yegnasubramanian, Edward J Pearce, Robert D Leone, Jesse Alt, Rana Rais, Barbara S Slusher, Drew M Pardoll, Jonathan D Powell, Jelani C Zarif
Metabolic reprogramming of tumor-associated macrophages using glutamine antagonist JHU083 drives tumor immunity in myeloid-rich prostate and bladder cancer tumors. Cancer immunology research (2024)
Alessandro Bonifazi, Michael Ellenberger, Zachary J Farino, Despoina Aslanoglou, Rana Rais, Sandra Pereira, José O Mantilla-Rivas, Comfort A Boateng, Amy J Eshleman, Aaron Janowsky, Margaret K Hahn, Gary J Schwartz, Barbara S Slusher, Amy Hauck Newman, Zachary Z Freyberg
Development of novel tools for dissection of central versus peripheral dopamine D 2 -like receptor signaling in dysglycemia. bioRxiv : the preprint server for biology (2024)
Monali Praharaj, Fan Shen, Alex J Lee, Liang Zhao, Thomas R Nirschl, Debebe Theodros, Alok K Singh, Xiaoxu Wang, Kenneth M Adusei, Kara A Lombardo, Raekwon A Williams, Laura A Sena, Elizabeth A Thompson, Ada J Tam, Srinivasan Yegnasubramanian, Edward J Pearce, Robert D Leone, Jesse Alt, Rana Rais, Barbara S Slusher, Drew M Pardoll, Jonathan D Powell, Jelani C Zarif
Metabolic Reprogramming of Tumor-Associated Macrophages Using Glutamine Antagonist JHU083 Drives Tumor Immunity in Myeloid-Rich Prostate and Bladder Cancers. Cancer immunology research 12 (7) (2024)
Yu Su, Meixiang Huang, Ajit G Thomas, John Maragakis, Kaitlyn D J Huizar, Yuxin Zheng, Ying Wu, Mohamed H Farah, Barbara S Slusher
GCPII Inhibition Promotes Remyelination after Peripheral Nerve Injury in Aged Mice. International journal of molecular sciences 25 (13) (2024)
Louis G Mueller, Barbara S Slusher, Takashi Tsukamoto
Empirical Analysis of Drug Targets for Nervous System Disorders. ACS chemical neuroscience (2024)
Alessandro Bonifazi, Michael Ellenberger, Zachary J Farino, Despoina Aslanoglou, Rana Rais, Sandra Pereira, José O Mantilla-Rivas, Comfort A Boateng, Amy J Eshleman, Aaron Janowsky, Margaret K Hahn, Gary J Schwartz, Barbara S Slusher, Amy Hauck Newman, Zachary Z Freyberg
Development of novel tools for dissection of central versus peripheral dopamine D 2 -like receptor signaling in dysglycemia. bioRxiv : the preprint server for biology (2024)
Louis G Mueller, Barbara S Slusher, Takashi Tsukamoto
Empirical Analysis of Drug Targets for Nervous System Disorders. ACS chemical neuroscience 15 (3) (2024)
Abdul A Waheed, Yanan Zhu, Eva Agostino, Lwar Naing, Yuta Hikichi, Ferri Soheilian, Seung-Wan Yoo, Yun Song, Peijun Zhang, Barbara S Slusher, Norman J Haughey, Eric O Freed
Neutral sphingomyelinase 2 is required for HIV-1 maturation. Proceedings of the National Academy of Sciences of the United States of America 120 (28) (2023)
Comfort A Boateng, Ashley N Nilson, Rebekah Placide, Mimi L Pham, Franziska M Jakobs, Noelia M Boldizsar, Scot McIntosh, Leia S Stallings, Ivana V Korankyi, Shreya Kelshikar, Nisha Shah, Diandra Panasis, Abigail Muccilli, Maria Ladik, Brianna Maslonka, Connor McBride, Moises Ximello Sanchez, Ebrar Akca, Mohammad Alkhatib, Julianna Saez, Catherine Nguyen, Emily Kurtyan, Jacquelyn DePierro, Raymond Crowthers, Dylan Brunt, Alessandro Bonifazi, Amy Hauck Newman, Rana Rais, Barbara S Slusher, R Benjamin Free, David R Sibley, Kent D Stewart, Chun Wu, Scott E Hemby, Thomas M Keck
Pharmacology and Therapeutic Potential of Benzothiazole Analogues for Cocaine Use Disorder. Journal of medicinal chemistry (2023)
Run-Duo Gao, Michelle Taylor, Tamara McInnis, Zhenglan Chen, Sadakatali S Gori, Heather M LaPorte, Maxime A Siegler, Janet L Neisewander, Robert H Mach, Meharvan Singh, Barbara S Slusher, Rana Rais, Robert R Luedtke, Takashi Tsukamoto
Synthesis and Pharmacological Characterization of a Difluorinated Analogue of Reduced Haloperidol as a Sigma-1 Receptor Ligand. ACS chemical neuroscience 14 (5) (2023)
Kateřina Novotná, Lukáš Tenora, Eva Prchalová, James Paule, Jesse Alt, Vijay Veeravalli, Jenny Lam, Ying Wu, Ivan Snajdr, Sadakatali Gori, Vijaya Saradhi Mettu, Takashi Tsukamoto, Pavel Majer, Barbara S Slusher, Rana Rais
Discovery of tert -Butyl Ester Based 6-Diazo-5-oxo-l-norleucine Prodrugs for Enhanced Metabolic Stability and Tumor Delivery. Journal of medicinal chemistry (2023)
Bachchu Lal, Aditya Kulkarni, Joseph R McDermott, Rana Rais, Jesse Alt, Ying Wu, Hernando Lopez-Bertoni, Sophie Sall, Umesh Kathad, Jianli Zhou, Barbara S Slusher, Kishor Bhatia, John Laterra
Preclinical efficacy of LP-184, a tumor site activated synthetic lethal therapeutic, in glioblastoma. Clinical cancer research : an official journal of the American Association for Cancer Research (2023)
Kathryn M Lemberg, Eunus S Ali, Marcela Krecmerova, Joanna Marie H Aguilar, Jesse Alt, Diane E Peters, Liang Zhao, Ying Wu, Naziba Nuha, John M Asara, Verena Staedtke, Christine A Pratilas, Pavel Majer, Rana Rais, Issam Ben-Sahra, Barbara S Slusher
Pro-905, a novel purine antimetabolite, combines with glutamine amidotransferase inhibition to suppress growth of malignant peripheral nerve sheath tumor. Molecular cancer therapeutics (2023)
Run-Duo Gao, Michelle Taylor, Tamara McInnis, Zhenglan Chen, Sadakatali S Gori, Heather M LaPorte, Maxime A Siegler, Janet L Neisewander, Robert H Mach, Meharvan Singh, Barbara S Slusher, Rana Rais, Robert R Luedtke, Takashi Tsukamoto
Synthesis and Pharmacological Characterization of a Difluorinated Analogue of Reduced Haloperidol as a Sigma-1 Receptor Ligand. ACS chemical neuroscience (2023)
Meixiang Huang, Carolyn Tallon, Xiaolei Zhu, Kaitlyn D J Huizar, Silvia Picciolini, Ajit G Thomas, Lukas Tenora, Wathsala Liyanage, Francesca Rodà, Alice Gualerzi, Rangaramanujam M Kannan, Marzia Bedoni, Rana Rais, Barbara S Slusher
Microglial-Targeted nSMase2 Inhibitor Fails to Reduce Tau Propagation in PS19 Mice. Pharmaceutics 15 (9) (2023)
Diane E Peters, Lauren D Norris, Lukáš Tenora, Ivan Snajdr, András K Ponti, Xiaolei Zhu, Shinji Sakamoto, Vijayabhaskar Veeravalli, Manisha Pradhan, Jesse Alt, Ajit G Thomas, Pavel Majer, Rana Rais, Christine McDonald, Barbara S Slusher
A gut-restricted glutamate carboxypeptidase II inhibitor reduces monocytic inflammation and improves preclinical colitis. Science translational medicine 15 (708) (2023)
Carolyn Tallon, Benjamin J Bell, Medhinee M Malvankar, Pragney Deme, Carlos Nogueras-Ortiz, Erden Eren, Ajit G Thomas, Kristen R Hollinger, Arindom Pal, Maja Mustapic, Meixiang Huang, Kaleem Coleman, Tawnjerae R Joe, Rana Rais, Norman J Haughey, Dimitrios Kapogiannis, Barbara S Slusher
Inhibiting tau-induced elevated nSMase2 activity and ceramides is therapeutic in an Alzheimer's disease mouse model. Translational neurodegeneration 12 (1) (2023)
Run-Duo Gao, Michelle Taylor, Tamara McInnis, Zhenglan Chen, Sadakatali S Gori, Heather M LaPorte, Maxime A Siegler, Janet L Neisewander, Robert H Mach, Meharvan Singh, Barbara S Slusher, Rana Rais, Robert R Luedtke, Takashi Tsukamoto
Synthesis and Pharmacological Characterization of a Difluorinated Analogue of Reduced Haloperidol as a Sigma-1 Receptor Ligand. ACS chemical neuroscience 14 (5) (2023)
Carolyn Tallon, Benjamin J Bell, Medhinee M Malvankar, Pragney Deme, Carlos Nogueras-Ortiz, Erden Eren, Ajit G Thomas, Kristen R Hollinger, Arindom Pal, Maja Mustapic, Meixiang Huang, Kaleem Coleman, Tawnjerae R Joe, Rana Rais, Norman J Haughey, Dimitrios Kapogiannis, Barbara S Slusher
Inhibiting tau-induced elevated nSMase2 activity and ceramides is therapeutic in murine Alzheimer's disease. Research square (2023)
Seung-Wan Yoo, Abdul A Waheed, Pragney Deme, Sehmus Tohumeken, Rana Rais, Matthew D Smith, Catherine DeMarino, Peter A Calabresi, Fatah Kashanchi, Eric O Freed, Barbara S Slusher, Norman J Haughey
Inhibition of neutral sphingomyelinase 2 impairs HIV-1 envelope formation and substantially delays or eliminates viral rebound. Proceedings of the National Academy of Sciences of the United States of America 120 (28) (2023)
Run-Duo Gao, Michelle Taylor, Tamara McInnis, Zhenglan Chen, Sadakatali S Gori, Heather M LaPorte, Maxime A Siegler, Janet L Neisewander, Robert H Mach, Meharvan Singh, Barbara S Slusher, Rana Rais, Robert R Luedtke, Takashi Tsukamoto
Synthesis and Pharmacological Characterization of a Difluorinated Analogue of Reduced Haloperidol as a Sigma-1 Receptor Ligand. ACS chemical neuroscience 14 (5) (2023)
Run-Duo Gao, Michelle Taylor, Tamara McInnis, Zhenglan Chen, Sadakatali S Gori, Heather M LaPorte, Maxime A Siegler, Janet L Neisewander, Robert H Mach, Meharvan Singh, Barbara S Slusher, Rana Rais, Robert R Luedtke, Takashi Tsukamoto
Synthesis and Pharmacological Characterization of a Difluorinated Analogue of Reduced Haloperidol as a Sigma-1 Receptor Ligand. ACS chemical neuroscience (2023)
Akash K Kaushik, Amy Tarangelo, Lindsey K Boroughs, Mukundan Ragavan, Yuanyuan Zhang, Cheng-Yang Wu, Xiangyi Li, Kristen Ahumada, Jui-Chung Chiang, Vanina Toffessi Tcheuyap, Faeze Saatchi, Quyen N Do, Cissy Yong, Tracy Rosales, Christina Stevens, Aparna D Rao, Brandon Faubert, Panayotis Pachnis, Lauren G Zacharias, Hieu Vu, Feng Cai, Thomas P Mathews, Giannicola Genovese, Barbara S Slusher, Payal Kapur, Xiankai Sun, Matthew E Merritt, James Brugarolas, Ralph J DeBerardinis
In vivo characterization of glutamine metabolism identifies therapeutic targets in clear cell renal cell carcinoma. Science advances 8 (50) (2022)
Carolyn Tallon, Anjali Sharma, Zhi Zhang, Ajit G Thomas, Justin Ng, Xiaolei Zhu, Amanda Donoghue, Michael Schulte, Tawnjerae R Joe, Siva P Kambhampati, Rishi Sharma, Kevin Liaw, Sujatha Kannan, Rangaramanujam M Kannan, Barbara S Slusher
Dendrimer-2PMPA Delays Muscle Function Loss and Denervation in a Murine Model of Amyotrophic Lateral Sclerosis. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 19 (1) (2022)
Jerry Tsai, Sadakatali Gori, Jesse Alt, Sandhya Tiwari, Jitesh Iyer, Rashmi Talwar, Denish Hinsu, Kailash Ahirwar, Swayam Mohanty, Chintan Khunt, Brijesh Sutariya, Kaushal Jani, Venkatesha Venkatasubbaiah, Ashok Patel, Jasmin Meghapara, Kaushal Joshi, Rajanikanta Sahu, Vijay Rana, Prashant Nigade, Ravi S Talluri, Kadiyala V S N Murty, Kiritkumar Joshi, Vikram Ramanathan, Ang Li, Nasif Islam, Ivan Snajdr, Pavel Majer, Rana Rais, Barbara S Slusher, Luis A Garza
Topical SCD-153, a 4-methyl itaconate prodrug, for the treatment of alopecia areata. PNAS nexus 2 (1) (2022)
Akash K Kaushik, Amy Tarangelo, Lindsey K Boroughs, Mukundan Ragavan, Yuanyuan Zhang, Cheng-Yang Wu, Xiangyi Li, Kristen Ahumada, Jui-Chung Chiang, Vanina Toffessi Tcheuyap, Faeze Saatchi, Quyen N Do, Cissy Yong, Tracy Rosales, Christina Stevens, Aparna D Rao, Brandon Faubert, Panayotis Pachnis, Lauren G Zacharias, Hieu Vu, Feng Cai, Thomas P Mathews, Giannicola Genovese, Barbara S Slusher, Payal Kapur, Xiankai Sun, Matthew E Merritt, James Brugarolas, Ralph J DeBerardinis
In vivo characterization of glutamine metabolism identifies therapeutic targets in clear cell renal cell carcinoma. Science advances 8 (50) (2022)
Run-Duo Gao, Masahiro Maeda, Carolyn Tallon, Andrew P Feinberg, Barbara S Slusher, Takashi Tsukamoto
Effects of 6-Aminonicotinic Acid Esters on the Reprogrammed Epigenetic State of Distant Metastatic Pancreatic Carcinoma. ACS medicinal chemistry letters 13 (12) (2022)
Rana Rais, Kathryn M Lemberg, Lukáš Tenora, Matthew L Arwood, Arindom Pal, Jesse Alt, Ying Wu, Jenny Lam, Joanna Marie H Aguilar, Liang Zhao, Diane E Peters, Carolyn Tallon, Rajeev Pandey, Ajit G Thomas, Ranjeet P Dash, Tanguy Y Seiwert, Pavel Majer, Robert D Leone, Jonathan D Powell, Barbara S Slusher
Discovery of DRP-104, a tumor-targeted metabolic inhibitor prodrug. Science advances 8 (46) (2022)
Jerry Tsai, Sadakatali Gori, Jesse Alt, Sandhya Tiwari, Jitesh Iyer, Rashmi Talwar, Denish Hinsu, Kailash Ahirwar, Swayam Mohanty, Chintan Khunt, Brijesh Sutariya, Kaushal Jani, Venkatesha Venkatasubbaiah, Ashok Patel, Jasmin Meghapara, Kaushal Joshi, Rajanikanta Sahu, Vijay Rana, Prashant Nigade, Ravi S Talluri, Kadiyala V S N Murty, Kiritkumar Joshi, Vikram Ramanathan, Ang Li, Nasif Islam, Ivan Snajdr, Pavel Majer, Rana Rais, Barbara S Slusher, Luis A Garza
Topical SCD-153, a 4-methyl itaconate prodrug, for the treatment of alopecia areata. PNAS nexus 2 (1) (2022)
Arindom Pal, Sadakatali Gori, Seung-Wan Yoo, Ajit G Thomas, Ying Wu, Jacob Friedman, Lukáš Tenora, Harshit Bhasin, Jesse Alt, Norman Haughey, Barbara S Slusher, Rana Rais
Discovery of Orally Bioavailable and Brain-Penetrable Prodrugs of the Potent nSMase2 Inhibitor DPTIP. Journal of medicinal chemistry 65 (16) (2022)
Akash K Kaushik, Amy Tarangelo, Lindsey K Boroughs, Mukundan Ragavan, Yuanyuan Zhang, Cheng-Yang Wu, Xiangyi Li, Kristen Ahumada, Jui-Chung Chiang, Vanina Toffessi Tcheuyap, Faeze Saatchi, Quyen N Do, Cissy Yong, Tracy Rosales, Christina Stevens, Aparna D Rao, Brandon Faubert, Panayotis Pachnis, Lauren G Zacharias, Hieu Vu, Feng Cai, Thomas P Mathews, Giannicola Genovese, Barbara S Slusher, Payal Kapur, Xiankai Sun, Matthew E Merritt, James Brugarolas, Ralph J DeBerardinis
In vivo characterization of glutamine metabolism identifies therapeutic targets in clear cell renal cell carcinoma. Science advances 8 (50) (2022)
Run-Duo Gao, Masahiro Maeda, Carolyn Tallon, Andrew P Feinberg, Barbara S Slusher, Takashi Tsukamoto
Effects of 6-Aminonicotinic Acid Esters on the Reprogrammed Epigenetic State of Distant Metastatic Pancreatic Carcinoma. ACS medicinal chemistry letters 13 (12) (2022)
Jerry Tsai, Sadakatali Gori, Jesse Alt, Sandhya Tiwari, Jitesh Iyer, Rashmi Talwar, Denish Hinsu, Kailash Ahirwar, Swayam Mohanty, Chintan Khunt, Brijesh Sutariya, Kaushal Jani, Venkatesha Venkatasubbaiah, Ashok Patel, Jasmin Meghapara, Kaushal Joshi, Rajanikanta Sahu, Vijay Rana, Prashant Nigade, Ravi S Talluri, Kadiyala V S N Murty, Kiritkumar Joshi, Vikram Ramanathan, Ang Li, Nasif Islam, Ivan Snajdr, Pavel Majer, Rana Rais, Barbara S Slusher, Luis A Garza
Topical SCD-153, a 4-methyl itaconate prodrug, for the treatment of alopecia areata. PNAS nexus 2 (1) (2022)
Carolyn Tallon, Benjamin J Bell, Anjali Sharma, Arindom Pal, Medhinee M Malvankar, Ajit G Thomas, Seung-Wan Yoo, Kristen R Hollinger, Kaleem Coleman, Elizabeth L Wilkinson, Sujatha Kannan, Norman J Haughey, Rangaramanujam M Kannan, Rana Rais, Barbara S Slusher
Dendrimer-Conjugated nSMase2 Inhibitor Reduces Tau Propagation in Mice. Pharmaceutics 14 (10) (2022)
Akash K Kaushik, Amy Tarangelo, Lindsey K Boroughs, Mukundan Ragavan, Yuanyuan Zhang, Cheng-Yang Wu, Xiangyi Li, Kristen Ahumada, Jui-Chung Chiang, Vanina Toffessi Tcheuyap, Faeze Saatchi, Quyen N Do, Cissy Yong, Tracy Rosales, Christina Stevens, Aparna D Rao, Brandon Faubert, Panayotis Pachnis, Lauren G Zacharias, Hieu Vu, Feng Cai, Thomas P Mathews, Giannicola Genovese, Barbara S Slusher, Payal Kapur, Xiankai Sun, Matthew E Merritt, James Brugarolas, Ralph J DeBerardinis
In vivo characterization of glutamine metabolism identifies therapeutic targets in clear cell renal cell carcinoma. Science advances 8 (50) (2022)
Sadakatali S Gori, Ajit G Thomas, Arindom Pal, Robyn Wiseman, Dana V Ferraris, Run-Duo Gao, Ying Wu, Jesse Alt, Takashi Tsukamoto, Barbara S Slusher, Rana Rais
D-DOPA Is a Potent, Orally Bioavailable, Allosteric Inhibitor of Glutamate Carboxypeptidase II. Pharmaceutics 14 (10) (2022)
Akash K Kaushik, Amy Tarangelo, Lindsey K Boroughs, Mukundan Ragavan, Yuanyuan Zhang, Cheng-Yang Wu, Xiangyi Li, Kristen Ahumada, Jui-Chung Chiang, Vanina Toffessi Tcheuyap, Faeze Saatchi, Quyen N Do, Cissy Yong, Tracy Rosales, Christina Stevens, Aparna D Rao, Brandon Faubert, Panayotis Pachnis, Lauren G Zacharias, Hieu Vu, Feng Cai, Thomas P Mathews, Giannicola Genovese, Barbara S Slusher, Payal Kapur, Xiankai Sun, Matthew E Merritt, James Brugarolas, Ralph J DeBerardinis
In vivo characterization of glutamine metabolism identifies therapeutic targets in clear cell renal cell carcinoma. Science advances 8 (50) (2022)
Akash K Kaushik, Amy Tarangelo, Lindsey K Boroughs, Mukundan Ragavan, Yuanyuan Zhang, Cheng-Yang Wu, Xiangyi Li, Kristen Ahumada, Jui-Chung Chiang, Vanina Toffessi Tcheuyap, Faeze Saatchi, Quyen N Do, Cissy Yong, Tracy Rosales, Christina Stevens, Aparna D Rao, Brandon Faubert, Panayotis Pachnis, Lauren G Zacharias, Hieu Vu, Feng Cai, Thomas P Mathews, Giannicola Genovese, Barbara S Slusher, Payal Kapur, Xiankai Sun, Matthew E Merritt, James Brugarolas, Ralph J DeBerardinis
In vivo characterization of glutamine metabolism identifies therapeutic targets in clear cell renal cell carcinoma. Science advances 8 (50) (2022)
Akash K Kaushik, Amy Tarangelo, Lindsey K Boroughs, Mukundan Ragavan, Yuanyuan Zhang, Cheng-Yang Wu, Xiangyi Li, Kristen Ahumada, Jui-Chung Chiang, Vanina Toffessi Tcheuyap, Faeze Saatchi, Quyen N Do, Cissy Yong, Tracy Rosales, Christina Stevens, Aparna D Rao, Brandon Faubert, Panayotis Pachnis, Lauren G Zacharias, Hieu Vu, Feng Cai, Thomas P Mathews, Giannicola Genovese, Barbara S Slusher, Payal Kapur, Xiankai Sun, Matthew E Merritt, James Brugarolas, Ralph J DeBerardinis
In vivo characterization of glutamine metabolism identifies therapeutic targets in clear cell renal cell carcinoma. Science advances 8 (50) (2022)
Ilyas Berhane, Niyada Hin, Ajit G Thomas, Qian Huang, Chi Zhang, Vijayabhaskar Veeravalli, Ying Wu, Justin Ng, Jesse Alt, Camilo Rojas, Hiroe Hihara, Mika Aoki, Kyoko Yoshizawa, Tomoki Nishioka, Shuichi Suzuki, Shao-Qiu He, Qi Peng, Yun Guan, Xinzhong Dong, Srinivasa N Raja, Barbara S Slusher, Rana Rais, Takashi Tsukamoto
Thieno[2,3- d ]pyrimidine-Based Positive Allosteric Modulators of Human Mas-Related G Protein-Coupled Receptor X1 (MRGPRX1). Journal of medicinal chemistry 65 (4) (2022)
Md Imran Hossain, Ajit G Thomas, Fakhri Mahdi, Amna T Adam, Nicholas S Akins, Morgan M Woodard, Jason J Paris, Barbara S Slusher, Hoang V Le
An efficient synthetic route to l-γ-methyleneglutamine and its amide derivatives, and their selective anticancer activity. RSC advances 11 (13) (2021)
Morgan Dasovich, Junlin Zhuo, Jack A Goodman, Ajit Thomas, Robert Lyle McPherson, Aravinth Kumar Jayabalan, Veronica F Busa, Shang-Jung Cheng, Brennan A Murphy, Karli R Redinger, Yousef M O Alhammad, Anthony R Fehr, Takashi Tsukamoto, Barbara S Slusher, Jürgen Bosch, Huijun Wei, Anthony K L Leung
High-Throughput Activity Assay for Screening Inhibitors of the SARS-CoV-2 Mac1 Macrodomain. ACS chemical biology 17 (1) (2021)
Ondřej Nešuta, Ajit G Thomas, Jesse Alt, Niyada Hin, Anna Neužilová, Shunyou Long, Takashi Tsukamoto, Camilo Rojas, Huijun Wei, Barbara S Slusher
High Throughput Screening Cascade To Identify Human Aspartate N-Acetyltransferase (ANAT) Inhibitors for Canavan Disease. ACS chemical neuroscience 12 (18) (2021)
Tanina Arab, Emily R Mallick, Yiyao Huang, Liang Dong, Zhaohao Liao, Zezhou Zhao, Olesia A Gololobova, Barbara Smith, Norman J Haughey, Kenneth J Pienta, Barbara S Slusher, Patrick M Tarwater, Juan Pablo Tosar, Angela M Zivkovic, Wyatt N Vreeland, Michael E Paulaitis, Kennith W Witwer
Characterization of extracellular vesicles and synthetic nanoparticles with four orthogonal single-particle analysis platforms. Journal of extracellular vesicles 10 (6) (2021)
Jan Skácel, Barbara S Slusher, Takashi Tsukamoto
Small Molecule Inhibitors Targeting Biosynthesis of Ceramide, the Central Hub of the Sphingolipid Network. Journal of medicinal chemistry 64 (1) (2021)
Anjali Sharma, Kevin Liaw, Rishi Sharma, Ajit G Thomas, Barbara S Slusher, Sujatha Kannan, Rangaramanujam M Kannan
Targeting Mitochondria in Tumor-Associated Macrophages using a Dendrimer-Conjugated TSPO Ligand that Stimulates Antitumor Signaling in Glioblastoma. Biomacromolecules 21 (9) (2020)
Michal Šála, Kristen R Hollinger, Ajit G Thomas, Ranjeet P Dash, Carolyn Tallon, Vijayabhaskar Veeravalli, Lyndah Lovell, Martin Kögler, Hubert Hřebabecký, Eliška Procházková, Ondřej Nešuta, Amanda Donoghue, Jenny Lam, Rana Rais, Camilo Rojas, Barbara S Slusher, Radim Nencka
Novel Human Neutral Sphingomyelinase 2 Inhibitors as Potential Therapeutics for Alzheimer's Disease. Journal of medicinal chemistry 63 (11) (2020)
Benjamin J Bell, Medhinee M Malvankar, Carolyn Tallon, Barbara S Slusher
Sowing the Seeds of Discovery: Tau-Propagation Models of Alzheimer's Disease. ACS chemical neuroscience 11 (21) (2020)
Seung-Wan Yoo, Amit Agarwal, Matthew D Smith, Saja S Khuder, Emily G Baxi, Ajit G Thomas, Camilo Rojas, Mohammed Moniruzzaman, Barbara S Slusher, Dwight E Bergles, Peter A Calabresi, Norman J Haughey
Inhibition of neutral sphingomyelinase 2 promotes remyelination. Science advances 6 (40) (2020)
James J Vornov, Diane Peters, Mike Nedelcovych, Kristen Hollinger, Rana Rais, Barbara S Slusher
Looking for Drugs in All the Wrong Places: Use of GCPII Inhibitors Outside the Brain. Neurochemical research 45 (6) (2019)
Eva Prchalová, Niyada Hin, Ajit G Thomas, Vijayabhaskar Veeravalli, Justin Ng, Jesse Alt, Rana Rais, Camilo Rojas, Zhe Li, Hiroe Hihara, Mika Aoki, Kyoko Yoshizawa, Tomoki Nishioka, Shuichi Suzuki, Theresa Kopajtic, Sheena Chatrath, Qin Liu, Xinzhong Dong, Barbara S Slusher, Takashi Tsukamoto
Discovery of Benzamidine- and 1-Aminoisoquinoline-Based Human MAS-Related G-Protein-Coupled Receptor X1 (MRGPRX1) Agonists. Journal of medicinal chemistry 62 (18) (2019)
Anver Basha Shaik, Vivek Kumar, Alessandro Bonifazi, Adrian M Guerrero, Sophie L Cemaj, Alexandra Gadiano, Jenny Lam, Zheng-Xiong Xi, Rana Rais, Barbara S Slusher, Amy Hauck Newman
Investigation of Novel Primary and Secondary Pharmacophores and 3-Substitution in the Linking Chain of a Series of Highly Selective and Bitopic Dopamine D3 Receptor Antagonists and Partial Agonists. Journal of medicinal chemistry 62 (20) (2019)
Ranjeet P Dash, Tomáš Tichý, Vijayabhaskar Veeravalli, Jenny Lam, Jesse Alt, Ying Wu, Lukáš Tenora, Pavel Majer, Barbara S Slusher, Rana Rais
Enhanced Oral Bioavailability of 2-(Phosphonomethyl)-pentanedioic Acid (2-PMPA) from its (5-Methyl-2-oxo-1,3-dioxol-4-yl)methyl (ODOL)-Based Prodrugs. Molecular pharmaceutics 16 (10) (2019)
Robert D Leone, Liang Zhao, Judson M Englert, Im-Meng Sun, Min-Hee Oh, Im-Hong Sun, Matthew L Arwood, Ian A Bettencourt, Chirag H Patel, Jiayu Wen, Ada Tam, Richard L Blosser, Eva Prchalova, Jesse Alt, Rana Rais, Barbara S Slusher, Jonathan D Powell
Glutamine blockade induces divergent metabolic programs to overcome tumor immune evasion. Science (New York, N.Y.) 366 (6468) (2019)
Lukáš Tenora, Jesse Alt, Ranjeet P Dash, Alexandra J Gadiano, Kateřina Novotná, Vijayabhaskar Veeravalli, Jenny Lam, Quinn R Kirkpatrick, Kathryn M Lemberg, Pavel Majer, Rana Rais, Barbara S Slusher
Tumor-Targeted Delivery of 6-Diazo-5-oxo-l-norleucine (DON) Using Substituted Acetylated Lysine Prodrugs. Journal of medicinal chemistry 62 (7) (2019)
Rachel D Slack, Therese C Ku, Jianjing Cao, JoLynn B Giancola, Alessandro Bonifazi, Claus J Loland, Alexandra Gadiano, Jenny Lam, Rana Rais, Barbara S Slusher, Mark Coggiano, Gianluigi Tanda, Amy Hauck Newman
Structure-Activity Relationships for a Series of (Bis(4-fluorophenyl)methyl)sulfinyl Alkyl Alicyclic Amines at the Dopamine Transporter: Functionalizing the Terminal Nitrogen Affects Affinity, Selectivity, and Metabolic Stability. Journal of medicinal chemistry 63 (5) (2019)
Francisco O Battiti, Sophie L Cemaj, Adrian M Guerrero, Anver Basha Shaik, Jenny Lam, Rana Rais, Barbara S Slusher, Jeffery R Deschamps, Greg H Imler, Amy Hauck Newman, Alessandro Bonifazi
The Significance of Chirality in Drug Design and Synthesis of Bitopic Ligands as D3 Receptor (D3R) Selective Agonists. Journal of medicinal chemistry 62 (13) (2019)
Sarah C Zimmermann, Tomáš Tichý, Jan Vávra, Ranjeet P Dash, C Ethan Slusher, Alexandra J Gadiano, Ying Wu, Andrej Jančařík, Lukáš Tenora, Lenka Monincová, Eva Prchalová, Gregory J Riggins, Pavel Majer, Barbara S Slusher, Rana Rais
N-Substituted Prodrugs of Mebendazole Provide Improved Aqueous Solubility and Oral Bioavailability in Mice and Dogs. Journal of medicinal chemistry 61 (9) (2018)
Michael T Nedelcovych, Alexandra J Gadiano, Ying Wu, Arena A Manning, Ajit G Thomas, Saja S Khuder, Seung-Wan Yoo, Jiadi Xu, Justin C McArthur, Norman J Haughey, David J Volsky, Rana Rais, Barbara S Slusher
Pharmacokinetics of Intranasal versus Subcutaneous Insulin in the Mouse. ACS chemical neuroscience 9 (4) (2018)
Rana Rais, Jan Vávra, Tomáš Tichý, Ranjeet P Dash, Alexandra J Gadiano, Lukáš Tenora, Lenka Monincová, Cyril Bařinka, Jesse Alt, Sarah C Zimmermann, C Ethan Slusher, Ying Wu, Krystyna Wozniak, Pavel Majer, Takashi Tsukamoto, Barbara S Slusher
Discovery of a para-Acetoxy-benzyl Ester Prodrug of a Hydroxamate-Based Glutamate Carboxypeptidase II Inhibitor as Oral Therapy for Neuropathic Pain. Journal of medicinal chemistry 60 (18) (2017)
Mu-Fa Zou, Jianjing Cao, Ara M Abramyan, Theresa Kopajtic, Claudio Zanettini, Daryl A Guthrie, Rana Rais, Barbara S Slusher, Lei Shi, Claus J Loland, Amy Hauck Newman
Structure-Activity Relationship Studies on a Series of 3α-[Bis(4-fluorophenyl)methoxy]tropanes and 3α-[Bis(4-fluorophenyl)methylamino]tropanes As Novel Atypical Dopamine Transporter (DAT) Inhibitors for the Treatment of Cocaine Use Disorders. Journal of medicinal chemistry 60 (24) (2017)
Michael T Nedelcovych, Arena A Manning, Svetlana Semenova, Charlene Gamaldo, Norman J Haughey, Barbara S Slusher
The Psychiatric Impact of HIV. ACS chemical neuroscience 8 (7) (2017)
Michael T Nedelcovych, Lukáš Tenora, Boe-Hyun Kim, Jennifer Kelschenbach, Wei Chao, Eran Hadas, Andrej Jančařík, Eva Prchalová, Sarah C Zimmermann, Ranjeet P Dash, Alexandra J Gadiano, Caroline Garrett, Georg Furtmüller, Byoungchol Oh, Gerald Brandacher, Jesse Alt, Pavel Majer, David J Volsky, Rana Rais, Barbara S Slusher
N-(Pivaloyloxy)alkoxy-carbonyl Prodrugs of the Glutamine Antagonist 6-Diazo-5-oxo-l-norleucine (DON) as a Potential Treatment for HIV Associated Neurocognitive Disorders. Journal of medicinal chemistry 60 (16) (2017)
Brian H Yokley, Matthew Hartman, Barbara S Slusher
Role of Academic Drug Discovery in the Quest for New CNS Therapeutics. ACS chemical neuroscience 8 (3) (2017)
Michael Nedelcovych, Ranjeet P Dash, Lukáš Tenora, Sarah C Zimmermann, Alexandra J Gadiano, Caroline Garrett, Jesse Alt, Kristen R Hollinger, Elie Pommier, Andrej Jančařík, Camilo Rojas, Ajit G Thomas, Ying Wu, Krystyna Wozniak, Pavel Majer, Barbara S Slusher, Rana Rais
Enhanced Brain Delivery of 2-(Phosphonomethyl)pentanedioic Acid Following Intranasal Administration of Its γ-Substituted Ester Prodrugs. Molecular pharmaceutics 14 (10) (2017)