Jan Cools

ORCID

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 24

Top Venues

Nature cancer

Blood

Leukemia

Nature communications

VIB

KU Leuven (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

VIB

Belgium

Group Leader :: Center for Cancer Biology

KU Leuven

Belgium

Professor :: Department of Human Genetics

KU Leuven

Belgium

postdoctoral researcher :: Center for Human Genetics

Harvard Medical School

United States

postdoctoral researcher

Education History

KU Leuven

Belgium

PHD :: Department of Human Genetics

KU Leuven

Belgium

MSC :: Bio-engineering

Publications

Charles E de Bock, Jan Cools
Selective targeting of malignant T cells. Nature cancer (2024)
Charles E de Bock, Jan Cools
Selective targeting of malignant T cells. Nature cancer 5 (6) (2024)
Margo Aertgeerts, Sarah Meyers, Sofie Demeyer, Heidi Segers, Jan Cools
Unlocking the Complexity: Exploration of Acute Lymphoblastic Leukemia at the Single Cell Level. Molecular diagnosis & therapy (2024)
Charles E de Bock, Jan Cools
Selective targeting of malignant T cells. Nature cancer 5 (6) (2024)
Patricia Altea-Manzano, Ginevra Doglioni, Yawen Liu, Alejandro M Cuadros, Emma Nolan, Juan Fernández-García, Qi Wu, Mélanie Planque, Kathrin Julia Laue, Florencia Cidre-Aranaz, Xiao-Zheng Liu, Oskar Marin-Bejar, Joke Van Elsen, Ines Vermeire, Dorien Broekaert, Sofie Demeyer, Xander Spotbeen, Jakub Idkowiak, Aurélie Montagne, Margherita Demicco, H Furkan Alkan, Nick Rabas, Carla Riera-Domingo, François Richard, Tatjana Geukens, Maxim De Schepper, Sophia Leduc, Sigrid Hatse, Yentl Lambrechts, Emily Jane Kay, Sergio Lilla, Alisa Alekseenko, Vincent Geldhof, Bram Boeckx, Celia de la Calle Arregui, Giuseppe Floris, Johannes V Swinnen, Jean-Christophe Marine, Diether Lambrechts, Vicent Pelechano, Massimilliano Mazzone, Sara R Zanivan, Jan Cools, Hans P M W Wildiers, Veronique Baud, Thomas G P Grünewald, Uri Ben-David, Christine Desmedt, Ilaria Malanchi, Sarah-Maria Fendt
A palmitate-rich metastatic niche enables metastasis growth via p65 acetylation resulting in pro-metastatic NF-κB signaling. Nature cancer (2023)
Patricia Altea-Manzano, Ginevra Doglioni, Yawen Liu, Alejandro M Cuadros, Emma Nolan, Juan Fernández-García, Qi Wu, Mélanie Planque, Kathrin Julia Laue, Florencia Cidre-Aranaz, Xiao-Zheng Liu, Oskar Marin-Bejar, Joke Van Elsen, Ines Vermeire, Dorien Broekaert, Sofie Demeyer, Xander Spotbeen, Jakub Idkowiak, Aurélie Montagne, Margherita Demicco, H Furkan Alkan, Nick Rabas, Carla Riera-Domingo, François Richard, Tatjana Geukens, Maxim De Schepper, Sophia Leduc, Sigrid Hatse, Yentl Lambrechts, Emily Jane Kay, Sergio Lilla, Alisa Alekseenko, Vincent Geldhof, Bram Boeckx, Celia de la Calle Arregui, Giuseppe Floris, Johannes V Swinnen, Jean-Christophe Marine, Diether Lambrechts, Vicent Pelechano, Massimilliano Mazzone, Sara R Zanivan, Jan Cools, Hans P M W Wildiers, Veronique Baud, Thomas G P Grünewald, Uri Ben-David, Christine Desmedt, Ilaria Malanchi, Sarah-Maria Fendt
A palmitate-rich metastatic niche enables metastasis growth via p65 acetylation resulting in pro-metastatic NF-κB signaling. Nature cancer (2023)
Patricia Altea-Manzano, Ginevra Doglioni, Yawen Liu, Alejandro M Cuadros, Emma Nolan, Juan Fernández-García, Qi Wu, Mélanie Planque, Kathrin Julia Laue, Florencia Cidre-Aranaz, Xiao-Zheng Liu, Oskar Marin-Bejar, Joke Van Elsen, Ines Vermeire, Dorien Broekaert, Sofie Demeyer, Xander Spotbeen, Jakub Idkowiak, Aurélie Montagne, Margherita Demicco, H Furkan Alkan, Nick Rabas, Carla Riera-Domingo, François Richard, Tatjana Geukens, Maxim De Schepper, Sophia Leduc, Sigrid Hatse, Yentl Lambrechts, Emily Jane Kay, Sergio Lilla, Alisa Alekseenko, Vincent Geldhof, Bram Boeckx, Celia de la Calle Arregui, Giuseppe Floris, Johannes V Swinnen, Jean-Christophe Marine, Diether Lambrechts, Vicent Pelechano, Massimilliano Mazzone, Sara R Zanivan, Jan Cools, Hans P M W Wildiers, Veronique Baud, Thomas G P Grünewald, Uri Ben-David, Christine Desmedt, Ilaria Malanchi, Sarah-Maria Fendt
A palmitate-rich metastatic niche enables metastasis growth via p65 acetylation resulting in pro-metastatic NF-κB signaling. Nature cancer (2023)
Patricia Altea-Manzano, Ginevra Doglioni, Yawen Liu, Alejandro M Cuadros, Emma Nolan, Juan Fernández-García, Qi Wu, Mélanie Planque, Kathrin Julia Laue, Florencia Cidre-Aranaz, Xiao-Zheng Liu, Oskar Marin-Bejar, Joke Van Elsen, Ines Vermeire, Dorien Broekaert, Sofie Demeyer, Xander Spotbeen, Jakub Idkowiak, Aurélie Montagne, Margherita Demicco, H Furkan Alkan, Nick Rabas, Carla Riera-Domingo, François Richard, Tatjana Geukens, Maxim De Schepper, Sophia Leduc, Sigrid Hatse, Yentl Lambrechts, Emily Jane Kay, Sergio Lilla, Alisa Alekseenko, Vincent Geldhof, Bram Boeckx, Celia de la Calle Arregui, Giuseppe Floris, Johannes V Swinnen, Jean-Christophe Marine, Diether Lambrechts, Vicent Pelechano, Massimilliano Mazzone, Sara R Zanivan, Jan Cools, Hans P M W Wildiers, Veronique Baud, Thomas G P Grünewald, Uri Ben-David, Christine Desmedt, Ilaria Malanchi, Sarah-Maria Fendt
A palmitate-rich metastatic niche enables metastasis growth via p65 acetylation resulting in pro-metastatic NF-κB signaling. Nature cancer (2023)
Marlies Vanden Bempt, Koen Debackere, Sofie Demeyer, Quentin Van Thillo, Nienke Meeuws, Cristina Prieto Fernandez, Sarah Provost, Nicole Mentens, Kris Jacobs, Olga Gielen, David Nittner, Seishi Ogawa, Keisuke Kataoka, Carlos Graux, Thomas A Tousseyn, Jan Cools, Daan Dierickx
Aberrant MYCN expression drives oncogenic hijacking of EZH2 as a transcriptional activator in peripheral T cell lymphoma. Blood (2022)
Matteo Rossi, Patricia Altea-Manzano, Margherita Demicco, Ginevra Doglioni, Laura Bornes, Marina Fukano, Anke Vandekeere, Alejandro M Cuadros, Juan Fernández-García, Carla Riera-Domingo, Cristina Jauset, Mélanie Planque, Hamza Furkan Alkan, David Nittner, Dongmei Zuo, Lindsay A Broadfield, Sweta Parik, Antonino Alejandro Pane, Francesca Rizzollo, Gianmarco Rinaldi, Tao Zhang, Shao Thing Teoh, Arin B Aurora, Panagiotis Karras, Ines Vermeire, Dorien Broekaert, Joke Van Elsen, Maximilian Martin Ludwig Knott, Martin F Orth, Sofie Demeyer, Guy Eelen, Lacey E Dobrolecki, Ayse Bassez, Thomas Van Brussel, Karl Sotlar, Michael T Lewis, Harald Bartsch, Dana L E Vergoossen, Peter van Veelen, Peter Carmeliet, Jan Cools, Sean J Morrison, Jean-Christophe Marine, Diether Lambrechts, Massimiliano Mazzone, Gregory James Hannon, Sophia Y Lunt, Thomas G P Grünewald, Morag Park, Jacco van Rheenen, Sarah-Maria Fendt
PHGDH heterogeneity potentiates cancer cell dissemination and metastasis. Nature 605 (7911) (2022)
Inge Lodewijckx, Jan Cools
Deregulation of the Interleukin-7 Signaling Pathway in Lymphoid Malignancies. Pharmaceuticals (Basel, Switzerland) 14 (5) (2021)
Inge Govaerts, Cristina Prieto, Charlien Vandersmissen, Olga Gielen, Kris Jacobs, Sarah Provost, David Nittner, Johan Maertens, Nancy Boeckx, Kim De Keersmaecker, Heidi Segers, Jan Cools
PSEN1-selective gamma-secretase inhibition in combination with kinase or XPO-1 inhibitors effectively targets T cell acute lymphoblastic leukemia. Journal of hematology & oncology 14 (1) (2021)
Danika Di Giacomo, Roberta La Starza, Paolo Gorello, Fabrizia Pellanera, Zeynep Kalender Atak, Kim De Keersmaecker, Valentina Pierini, Christine J Harrison, Silvia Arniani, Martina Moretti, Nicoletta Testoni, Giovanna De Santis, Giovanni Roti, Caterina Matteucci, Renato Bassan, Peter Vandenberghe, Stein Aerts, Jan Cools, Beat Bornhauser, Jean-Pierre Bourquin, Rocco Giovanni Piazza, Cristina Mecucci
14q32 rearrangements deregulating BCL11B mark a distinct subgroup of T-lymphoid and myeloid immature acute leukemia. Blood 138 (9) (2021)
Quentin Van Thillo, Jolien De Bie, Janith A Seneviratne, Sofie Demeyer, Sofia A Omari, Anushree Balachandran, Vicki Zhai, Wai L Tam, Bram Sweron, Ellen Geerdens, Olga Gielen, Sarah Provost, Heidi Segers, Nancy Boeckx, Glenn M Marshall, Belamy B Cheung, Kiyotaka Isobe, Itaru Kato, Junko Takita, Timothy G Amos, Ira W Deveson, Hannah McCalmont, Richard B Lock, Ethan P Oxley, Maximilian M Garwood, Ross A Dickins, Anne Uyttebroeck, Daniel R Carter, Jan Cools, Charles E de Bock
Oncogenic cooperation between TCF7-SPI1 and NRAS(G12D) requires β-catenin activity to drive T-cell acute lymphoblastic leukemia. Nature communications 12 (1) (2021)
Heidi Segers, Jan Cools
Genomics, Transcriptomics, and Minimal Residual Disease Detection: The Winning Team to Guide Treatment of Acute Lymphoblastic Leukemia. Blood cancer discovery 2 (4) (2021)
Charles E de Bock, Jan Cools
BETter insight into PRC2-mutated T-ALL. Blood 138 (19) (2021)
Jordy C G van der Zwet, Jessica G C A M Buijs-Gladdines, Valentina Cordoʹ, Donna O Debets, Willem K Smits, Zhongli Chen, Jelle Dylus, Guido J R Zaman, Maarten Altelaar, Koichi Oshima, Beat C Bornhauser, Jean-Pierre Bourquin, Jan Cools, Adolfo A Ferrando, H Josef Vormoor, Rob Pieters, Britta Vormoor, Jules P P Meijerink
MAPK-ERK is a central pathway in T-cell acute lymphoblastic leukemia that drives steroid resistance. Leukemia 35 (12) (2021)
Koen Debackere, Lukas Marcelis, Sofie Demeyer, Marlies Vanden Bempt, Nicole Mentens, Olga Gielen, Kris Jacobs, Michael Broux, Gregor Verhoef, Lucienne Michaux, Carlos Graux, Iwona Wlodarska, Philippe Gaulard, Laurence L de Leval, Thomas Tousseyn, Jan Cools, Daan Dierickx
Fusion transcripts FYN-TRAF3IP2 and KHDRBS1-LCK hijack T cell receptor signaling in peripheral T-cell lymphoma, not otherwise specified. Nature communications 12 (1) (2021)
Roger A Habets, Charles E de Bock, Lutgarde Serneels, Inge Lodewijckx, Delphine Verbeke, David Nittner, Rajeshwar Narlawar, Sofie Demeyer, James Dooley, Adrian Liston, Tom Taghon, Jan Cools, Bart De Strooper
Safe targeting of T cell acute lymphoblastic leukemia by pathology-specific NOTCH inhibition. Science translational medicine 11 (494) (2020)
Delphine Verbeke, Sofie Demeyer, Cristina Prieto, Charles E de Bock, Jolien De Bie, Olga Gielen, Kris Jacobs, Nicole Mentens, Bronte Manouk Verhoeven, Anne Uyttebroeck, Nancy Boeckx, Kim De Keersmaecker, Johan Maertens, Heidi Segers, Jan Cools
The XPO1 Inhibitor KPT-8602 Synergizes with Dexamethasone in Acute Lymphoblastic Leukemia. Clinical cancer research : an official journal of the American Association for Cancer Research 26 (21) (2020)
Charles E de Bock, Jan Cools
JAK3 mutations and HOXA9 expression are important cooperating events in T-cell acute lymphoblastic leukemia. Molecular & cellular oncology 5 (3) (2018)
Jolien De Bie, Sofie Demeyer, Llucia Alberti Servera, Ellen Geerdens, Heidi Segers, Michaël Broux, Kim De Keersmaecker, Lucienne Michaux, Peter Vandenberghe, Thierry Voet, Nancy Boeckx, Anne Uyttebroeck, Jan Cools
Single-cell sequencing reveals the origin and the order of mutation acquisition in T-cell acute lymphoblastic leukemia. Leukemia 32 (6) (2018)
Sandrine Degryse, Simon Bornschein, Charles E de Bock, Emilie Leroy, Marlies Vanden Bempt, Sofie Demeyer, Kris Jacobs, Ellen Geerdens, Olga Gielen, Jean Soulier, Christine J Harrison, Stefan N Constantinescu, Jan Cools
Mutant JAK3 signaling is increased by loss of wild-type JAK3 or by acquisition of secondary JAK3 mutations in T-ALL. Blood 131 (4) (2017)
Tiziana Girardi, Carmen Vicente, Jan Cools, Kim De Keersmaecker
The genetics and molecular biology of T-ALL. Blood 129 (9) (2017)

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Publication Activity (10 Years)

Top Topics

Top Venues

Jan Cools