Judy Hirst

ResearcherID ORCID

Publication Activity (10 Years)

Years Active: 2016-2024
Publications (10 Years): 47

Top Topics

Electron Transfer

Drosophila Melanogaster

Respiratory Tract

Top Venues

Science (New York, N.Y.)

The EMBO journal

Journal of the American Chemical Society

This page only lists publications with an associated author ORCID identifier.

Publications

Zhan Yin, Ahmed-Noor A Agip, Hannah R Bridges, Judy Hirst
Structural insights into respiratory complex I deficiency and assembly from the mitochondrial disease-related ndufs4 -/- mouse. The EMBO journal (2024)
Zhan Yin, Ahmed-Noor A Agip, Hannah R Bridges, Judy Hirst
Structural insights into respiratory complex I deficiency and assembly from the mitochondrial disease-related ndufs4 -/- mouse. The EMBO journal 43 (2) (2024)
Zhan Yin, Ahmed-Noor A Agip, Hannah R Bridges, Judy Hirst
Structural insights into respiratory complex I deficiency and assembly from the mitochondrial disease-related ndufs4 -/- mouse. The EMBO journal 43 (2) (2024)
Zhan Yin, Ahmed-Noor A Agip, Hannah R Bridges, Judy Hirst
Structural insights into respiratory complex I deficiency and assembly from the mitochondrial disease-related ndufs4 -/- mouse. The EMBO journal 43 (2) (2024)
Zhan Yin, Ahmed-Noor A Agip, Hannah R Bridges, Judy Hirst
Structural insights into respiratory complex I deficiency and assembly from the mitochondrial disease-related ndufs4 -/- mouse. The EMBO journal (2024)
Zhan Yin, Ahmed-Noor A Agip, Hannah R Bridges, Judy Hirst
Structural insights into respiratory complex I deficiency and assembly from the mitochondrial disease-related ndufs4 -/- mouse. The EMBO journal 43 (2) (2024)
Daniel N Grba, John J Wright, Zhan Yin, William Fisher, Judy Hirst
Molecular mechanism of the ischemia-induced regulatory switch in mammalian complex I. Science (New York, N.Y.) 384 (6701) (2024)
Zhan Yin, Ahmed-Noor A Agip, Hannah R Bridges, Judy Hirst
Structural insights into respiratory complex I deficiency and assembly from the mitochondrial disease-related ndufs4 -/- mouse. The EMBO journal 43 (2) (2024)
Daniel N Grba, John J Wright, Zhan Yin, William Fisher, Judy Hirst
Molecular mechanism of the ischemia-induced regulatory switch in mammalian complex I. Science (New York, N.Y.) 384 (6701) (2024)
Zhan Yin, Ahmed-Noor A Agip, Hannah R Bridges, Judy Hirst
Structural insights into respiratory complex I deficiency and assembly from the mitochondrial disease-related ndufs4 -/- mouse. The EMBO journal 43 (2) (2024)
Ahmed-Noor A Agip, Injae Chung, Alvaro Sanchez-Martinez, Alexander J Whitworth, Judy Hirst
Cryo-EM structures of mitochondrial respiratory complex I from Drosophila melanogaster . eLife 12 (2023)
Hannah R Bridges, James N Blaza, Zhan Yin, Injae Chung, Michael N Pollak, Judy Hirst
Structural basis of mammalian respiratory complex I inhibition by medicinal biguanides. Science (New York, N.Y.) 379 (6630) (2023)
Ahmed-Noor A Agip, Injae Chung, Alvaro Sanchez-Martinez, Alexander J Whitworth, Judy Hirst
Cryo-EM structures of mitochondrial respiratory complex I from Drosophila melanogaster . eLife 12 (2023)
Ahmed-Noor A Agip, Injae Chung, Alvaro Sanchez-Martinez, Alexander J Whitworth, Judy Hirst
Cryo-EM structures of mitochondrial respiratory complex I from Drosophila melanogaster . eLife 12 (2023)
Hannah R Bridges, James N Blaza, Zhan Yin, Injae Chung, Michael N Pollak, Judy Hirst
Structural basis of mammalian respiratory complex I inhibition by medicinal biguanides. Science (New York, N.Y.) 379 (6630) (2023)
Jana Eisermann, John J Wright, James D E T Wilton-Ely, Judy Hirst, Maxie M Roessler
Using light scattering to assess how phospholipid-protein interactions affect complex I functionality in liposomes. RSC chemical biology 4 (6) (2023)
Ahmed-Noor A Agip, Injae Chung, Alvaro Sanchez-Martinez, Alexander J Whitworth, Judy Hirst
Cryo-EM structures of mitochondrial respiratory complex I from Drosophila melanogaster . eLife 12 (2023)
Zijian Fang, Giuditta Corbizi Fattori, Thomas McKerrell, Rebecca H Boucher, Aimee Jackson, Rachel S Fletcher, Dorian Forte, Jose-Ezequiel Martin, Sonia Fox, James Roberts, Rachel Glover, Erica Harris, Hannah R Bridges, Luigi Grassi, Alba Rodriguez-Meira, Adam J Mead, Stephen Knapper, Joanne Ewing, Nauman M Butt, Manish Jain, Sebastian Francis, Fiona J Clark, Jason Coppell, Mary Frances Frances McMullin, Frances Wadelin, Srinivasan Narayanan, Dragana Milojkovic, Mark W Drummond, Mallika Sekhar, Hesham ElDaly, Judy Hirst, Maike Paramor, Elizabeth Joanna Baxter, Anna L Godfrey, Claire N Harrison, Simon Mendez-Ferrer
Tamoxifen for the treatment of myeloproliferative neoplasms: A Phase II clinical trial and exploratory analysis. Nature communications 14 (1) (2023)
Hannah R Bridges, James N Blaza, Zhan Yin, Injae Chung, Michael N Pollak, Judy Hirst
Structural basis of mammalian respiratory complex I inhibition by medicinal biguanides. Science (New York, N.Y.) 379 (6630) (2023)
Hannah R Bridges, James N Blaza, Zhan Yin, Injae Chung, Michael N Pollak, Judy Hirst
Structural basis of mammalian respiratory complex I inhibition by medicinal biguanides. Science (New York, N.Y.) 379 (6630) (2023)
Hannah R Bridges, James N Blaza, Zhan Yin, Injae Chung, Michael N Pollak, Judy Hirst
Structural basis of mammalian respiratory complex I inhibition by medicinal biguanides. Science (New York, N.Y.) 379 (6630) (2023)
Hannah R Bridges, James N Blaza, Zhan Yin, Injae Chung, Michael N Pollak, Judy Hirst
Structural basis of mammalian respiratory complex I inhibition by medicinal biguanides. Science (New York, N.Y.) 379 (6630) (2023)
Ahmed-Noor A Agip, Injae Chung, Alvaro Sanchez-Martinez, Alexander J Whitworth, Judy Hirst
Cryo-EM structures of mitochondrial respiratory complex I from Drosophila melanogaster . eLife 12 (2023)
Ahmed-Noor A Agip, Injae Chung, Alvaro Sanchez-Martinez, Alexander J Whitworth, Judy Hirst
Cryo-EM structures of mitochondrial respiratory complex I from Drosophila melanogaster . eLife 12 (2023)
Daniel N Grba, Injae Chung, Hannah R Bridges, Ahmed-Noor A Agip, Judy Hirst
Investigation of hydrated channels and proton pathways in a high-resolution cryo-EM structure of mammalian complex I. Science advances 9 (31) (2023)
Owen D Jarman, Judy Hirst
Membrane-domain mutations in respiratory complex I impede catalysis but do not uncouple proton pumping from ubiquinone reduction. PNAS nexus 1 (5) (2022)
Owen D Jarman, Judy Hirst
Membrane-domain mutations in respiratory complex I impede catalysis but do not uncouple proton pumping from ubiquinone reduction. PNAS nexus 1 (5) (2022)
Owen D Jarman, Judy Hirst
Membrane-domain mutations in respiratory complex I impede catalysis but do not uncouple proton pumping from ubiquinone reduction. PNAS nexus 1 (5) (2022)
John J Wright, Olivier Biner, Injae Chung, Nils Burger, Hannah R Bridges, Judy Hirst
Reverse Electron Transfer by Respiratory Complex I Catalyzed in a Modular Proteoliposome System. Journal of the American Chemical Society 144 (15) (2022)
Injae Chung, John J Wright, Hannah R Bridges, Bozhidar S Ivanov, Olivier Biner, Caroline S Pereira, Guilherme Menegon Arantes, Judy Hirst
Cryo-EM structures define ubiquinone-10 binding to mitochondrial complex I and conformational transitions accompanying Q-site occupancy. Nature communications 13 (1) (2022)
Zhan Yin, Nils Burger, Duvaraka Kula-Alwar, Dunja Aksentijević, Hannah R Bridges, Hiran A Prag, Daniel N Grba, Carlo Viscomi, Andrew M James, Amin Mottahedin, Thomas Krieg, Michael P Murphy, Judy Hirst
Structural basis for a complex I mutation that blocks pathological ROS production. Nature communications 12 (1) (2021)
Andrew E Maclean, Hannah R Bridges, Mariana F Silva, Shujing Ding, Jana Ovciarikova, Judy Hirst, Lilach Sheiner
Complexome profile of Toxoplasma gondii mitochondria identifies divergent subunits of respiratory chain complexes including new subunits of cytochrome bc1 complex. PLoS pathogens 17 (3) (2021)
Hannah R Bridges, Justin G Fedor, James N Blaza, Andrea Di Luca, Alexander Jussupow, Owen D Jarman, John J Wright, Ahmed-Noor A Agip, Ana P Gamiz-Hernandez, Maxie M Roessler, Ville R I Kaila, Judy Hirst
Structure of inhibitor-bound mammalian complex I. Nature communications 11 (1) (2020)
David A Russell, Hannah R Bridges, Riccardo Serreli, Sarah L Kidd, Natalia Mateu, Thomas J Osberger, Hannah F Sore, Judy Hirst, David R Spring
Hydroxylated Rotenoids Selectively Inhibit the Proliferation of Prostate Cancer Cells. Journal of natural products 83 (6) (2020)
Olivier Biner, Justin G Fedor, Zhan Yin, Judy Hirst
Bottom-Up Construction of a Minimal System for Cellular Respiration and Energy Regeneration. ACS synthetic biology 9 (6) (2020)
Daniel N Grba, Judy Hirst
Mitochondrial complex I structure reveals ordered water molecules for catalysis and proton translocation. Nature structural & molecular biology 27 (10) (2020)
Zoe A Stephenson, Robert F Harvey, Kenneth R Pryde, Sarah Mistry, Rachel E Hardy, Riccardo Serreli, Injae Chung, Timothy Eh Allen, Mark Stoneley, Marion MacFarlane, Peter M Fischer, Judy Hirst, Barrie Kellam, Anne E Willis
Identification of a novel toxicophore in anti-cancer chemotherapeutics that targets mitochondrial respiratory complex I. eLife 9 (2020)
William E Robinson, Arnau Bassegoda, James N Blaza, Erwin Reisner, Judy Hirst
Understanding How the Rate of C-H Bond Cleavage Affects Formate Oxidation Catalysis by a Mo-Dependent Formate Dehydrogenase. Journal of the American Chemical Society 142 (28) (2020)
Judy Hirst, Edmund R S Kunji, John E Walker
Comment on "Protein assemblies ejected directly from native membranes yield complexes for mass spectrometry". Science (New York, N.Y.) 366 (6466) (2019)
Febin Varghese, James N Blaza, Andrew J Y Jones, Owen D Jarman, Judy Hirst
Deleting the IF1-like ζ subunit from Paracoccus denitrificans ATP synthase is not sufficient to activate ATP hydrolysis. Open biology 8 (1) (2019)
Katarzyna P Sokol, William E Robinson, Ana R Oliveira, Sonia Zacarias, Chong-Yong Lee, Christopher Madden, Arnau Bassegoda, Judy Hirst, Inês A C Pereira, Erwin Reisner
Reversible and Selective Interconversion of Hydrogen and Carbon Dioxide into Formate by a Semiartificial Formate Hydrogenlyase Mimic. Journal of the American Chemical Society 141 (44) (2019)
Judy Hirst
Open questions: respiratory chain supercomplexes-why are they there and what do they do? BMC biology 16 (1) (2018)
Ahmed-Noor A Agip, James N Blaza, Hannah R Bridges, Carlo Viscomi, Shaun Rawson, Stephen P Muench, Judy Hirst
Cryo-EM structures of complex I from mouse heart mitochondria in two biochemically defined states. Nature structural & molecular biology 25 (7) (2018)
Nolwenn Le Breton, John J Wright, Andrew J Y Jones, Enrico Salvadori, Hannah R Bridges, Judy Hirst, Maxie M Roessler
Using Hyperfine Electron Paramagnetic Resonance Spectroscopy to Define the Proton-Coupled Electron Transfer Reaction at Fe-S Cluster N2 in Respiratory Complex I. Journal of the American Chemical Society 139 (45) (2017)
Justin G Fedor, Andrew J Y Jones, Andrea Di Luca, Ville R I Kaila, Judy Hirst
Correlating kinetic and structural data on ubiquinone binding and reduction by respiratory complex I. Proceedings of the National Academy of Sciences of the United States of America 114 (48) (2017)
William E Robinson, Arnau Bassegoda, Erwin Reisner, Judy Hirst
Oxidation-State-Dependent Binding Properties of the Active Site in a Mo-Containing Formate Dehydrogenase. Journal of the American Chemical Society 139 (29) (2017)
Hannah R Bridges, Ville A Sirviö, Ahmed-Noor A Agip, Judy Hirst
Molecular features of biguanides required for targeting of mitochondrial respiratory complex I and activation of AMP-kinase. BMC biology 14 (2016)