Klaus Okkenhaug

Scopus Author ID Loop profile ORCID

Publication Activity (10 Years)

Years Active: 2015-2024
Publications (10 Years): 32

Top Venues

Science immunology

Nature communications

Journal of immunology (Baltimore, Md. : 1950)

EMBO reports

University of Cambridge

University of Toronto (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

University of Cambridge

United Kingdom

Professor of Immunology :: Department of Pathology

Babraham Institute

United Kingdom

Group Leader :: Laboratory of Lymphocyte Signalling and Development

Ludwig Institute for Cancer Research

United Kingdom

Postdoc :: Cell signalling

Education History

University of Toronto

Canada

PHD :: Immunology

University of Victoria

Canada

BSC :: Biochemistry

Publications

Sigrid S Skånland, Klaus Okkenhaug, Matthew S Davids
PI3K Inhibitors in Hematology: When One Door Closes…. Clinical cancer research : an official journal of the American Association for Cancer Research 30 (17) (2024)
Munetomo Takahashi, Tsz Y So, Vitalina Chamberlain-Evans, Robert Hughes, Juan Carlos Yam-Puc, Katarzyna Kania, Michelle Ruhle, Tiffeney Mann, Martijn J Schuijs, Paul Coupland, Dean John Naisbitt, Timotheus Y F Halim, Paul A Lyons, Pietro Lió, Rahul Roychoudhuri, Klaus Okkenhaug, David J Adams, Kenneth G C Smith, Duncan Ian Jodrell, Michael A Chapman, James E D Thaventhiran
Intratumoral antigen signaling traps CD8 + T cells to confine exhaustion to the tumor site. Science immunology 9 (95) (2024)
Munetomo Takahashi, Tsz Y So, Vitalina Chamberlain-Evans, Robert Hughes, Juan Carlos Yam-Puc, Katarzyna Kania, Michelle Ruhle, Tiffeney Mann, Martijn J Schuijs, Paul Coupland, Dean John Naisbitt, Timotheus Y F Halim, Paul A Lyons, Pietro Lió, Rahul Roychoudhuri, Klaus Okkenhaug, David J Adams, Kenneth G C Smith, Duncan Ian Jodrell, Michael A Chapman, James E D Thaventhiran
Intratumoral antigen signaling traps CD8 + T cells to confine exhaustion to the tumor site. Science immunology 9 (95) (2024)
Munetomo Takahashi, Tsz Y So, Vitalina Chamberlain-Evans, Robert Hughes, Juan Carlos Yam-Puc, Katarzyna Kania, Michelle Ruhle, Tiffeney Mann, Martijn J Schuijs, Paul Coupland, Dean John Naisbitt, Timotheus Y F Halim, Paul A Lyons, Pietro Lió, Rahul Roychoudhuri, Klaus Okkenhaug, David J Adams, Kenneth G C Smith, Duncan Ian Jodrell, Michael A Chapman, James E D Thaventhiran
Intratumoral antigen signaling traps CD8 + T cells to confine exhaustion to the tumor site. Science immunology 9 (95) (2024)
Munetomo Takahashi, Tsz Y So, Vitalina Chamberlain-Evans, Robert Hughes, Juan Carlos Yam-Puc, Katarzyna Kania, Michelle Ruhle, Tiffeney Mann, Martijn J Schuijs, Paul Coupland, Dean John Naisbitt, Timotheus Y F Halim, Paul A Lyons, Pietro Lió, Rahul Roychoudhuri, Klaus Okkenhaug, David J Adams, Kenneth G C Smith, Duncan Ian Jodrell, Michael A Chapman, James E D Thaventhiran
Intratumoral antigen signaling traps CD8 + T cells to confine exhaustion to the tumor site. Science immunology 9 (95) (2024)
Sigrid S Skånland, Klaus Okkenhaug, Matthew S Davids
PI3K inhibitors in hematology: When one door closes…. Clinical cancer research : an official journal of the American Association for Cancer Research (2024)
Sarah K Whiteside, Francis M Grant, Giorgia Alvisi, James Clarke, Leqi Tang, Charlotte J Imianowski, Baojie Zhang, Alexander C Evans, Alexander J Wesolowski, Alberto G Conti, Jie Yang, Sarah Nicol Lauder, Mathew Clement, Ian R Humphreys, James Dooley, Oliver T Burton, Adrian Liston, Marco Alloisio, Emanuele Voulaz, Jean Langhorne, Klaus Okkenhaug, Enrico Lugli, Rahul Roychoudhuri
Acquisition of suppressive function by conventional T cells limits antitumor immunity upon T reg depletion. Science immunology 8 (90) (2023)
Sarah K Whiteside, Francis M Grant, Giorgia Alvisi, James Clarke, Leqi Tang, Charlotte J Imianowski, Baojie Zhang, Alexander C Evans, Alexander J Wesolowski, Alberto G Conti, Jie Yang, Sarah Nicol Lauder, Mathew Clement, Ian R Humphreys, James Dooley, Oliver T Burton, Adrian Liston, Marco Alloisio, Emanuele Voulaz, Jean Langhorne, Klaus Okkenhaug, Enrico Lugli, Rahul Roychoudhuri
Acquisition of suppressive function by conventional T cells limits antitumor immunity upon T reg depletion. Science immunology 8 (90) (2023)
Sarah K Whiteside, Francis M Grant, Giorgia Alvisi, James Clarke, Leqi Tang, Charlotte J Imianowski, Baojie Zhang, Alexander C Evans, Alexander J Wesolowski, Alberto G Conti, Jie Yang, Sarah Nicol Lauder, Mathew Clement, Ian R Humphreys, James Dooley, Oliver T Burton, Adrian Liston, Marco Alloisio, Emanuele Voulaz, Jean Langhorne, Klaus Okkenhaug, Enrico Lugli, Rahul Roychoudhuri
Acquisition of suppressive function by conventional T cells limits antitumor immunity upon T reg depletion. Science immunology 8 (90) (2023)
Sarah K Whiteside, Francis M Grant, Giorgia Alvisi, James Clarke, Leqi Tang, Charlotte J Imianowski, Baojie Zhang, Alexander C Evans, Alexander J Wesolowski, Alberto G Conti, Jie Yang, Sarah Nicol Lauder, Mathew Clement, Ian R Humphreys, James Dooley, Oliver T Burton, Adrian Liston, Marco Alloisio, Emanuele Voulaz, Jean Langhorne, Klaus Okkenhaug, Enrico Lugli, Rahul Roychoudhuri
Acquisition of suppressive function by conventional T cells limits antitumor immunity upon T reg depletion. Science immunology 8 (90) (2023)
Sarah K Whiteside, Francis M Grant, Giorgia Alvisi, James Clarke, Leqi Tang, Charlotte J Imianowski, Baojie Zhang, Alexander C Evans, Alexander J Wesolowski, Alberto G Conti, Jie Yang, Sarah Nicol Lauder, Mathew Clement, Ian R Humphreys, James Dooley, Oliver T Burton, Adrian Liston, Marco Alloisio, Emanuele Voulaz, Jean Langhorne, Klaus Okkenhaug, Enrico Lugli, Rahul Roychoudhuri
Acquisition of suppressive function by conventional T cells limits antitumor immunity upon T reg depletion. Science immunology 8 (90) (2023)
Sarah K Whiteside, Francis M Grant, Giorgia Alvisi, James Clarke, Leqi Tang, Charlotte J Imianowski, Baojie Zhang, Alexander C Evans, Alexander J Wesolowski, Alberto G Conti, Jie Yang, Sarah Nicol Lauder, Mathew Clement, Ian R Humphreys, James Dooley, Oliver T Burton, Adrian Liston, Marco Alloisio, Emanuele Voulaz, Jean Langhorne, Klaus Okkenhaug, Enrico Lugli, Rahul Roychoudhuri
Acquisition of suppressive function by conventional T cells limits antitumor immunity upon T reg depletion. Science immunology 8 (90) (2023)
Hazel Stewart, Roberta Palmulli, Kristoffer Haurum Johansen, Naomi McGovern, Ola M Shehata, George W Carnell, Hannah K Jackson, Jin S Lee, Jonathan C Brown, Thomas Burgoyne, Jonathan L Heeney, Klaus Okkenhaug, Andrew E Firth, Andrew A Peden, James R Edgar
Tetherin antagonism by SARS-CoV-2 ORF3a and spike protein enhances virus release. EMBO reports (2023)
Sarah K Whiteside, Francis M Grant, Giorgia Alvisi, James Clarke, Leqi Tang, Charlotte J Imianowski, Baojie Zhang, Alexander C Evans, Alexander J Wesolowski, Alberto G Conti, Jie Yang, Sarah Nicol Lauder, Mathew Clement, Ian R Humphreys, James Dooley, Oliver T Burton, Adrian Liston, Marco Alloisio, Emanuele Voulaz, Jean Langhorne, Klaus Okkenhaug, Enrico Lugli, Rahul Roychoudhuri
Acquisition of suppressive function by conventional T cells limits antitumor immunity upon T reg depletion. Science immunology 8 (90) (2023)
Ondrej Suchanek, John R Ferdinand, Zewen Kelvin Tuong, Sathi Wijeyesinghe, Anita Chandra, Ann-Katrin Clauder, Larissa Nogueira Almeida, Simon Clare, Katherine Harcourt, Christopher J Ward, Rachael J M Bashford-Rogers, Trevor Lawley, Rudolf Armin Manz, Klaus Okkenhaug, David Masopust, Menna R Clatworthy
Tissue-resident B cells orchestrate macrophage polarisation and function. Nature communications 14 (1) (2023)
Simon Eschweiler, Ciro Ramírez-Suástegui, Yingcong Li, Emma King, Lindsey Chudley, Jaya Thomas, Oliver Wood, Adrian von Witzleben, Danielle Jeffrey, Katy J McCann, Hayley Simon, Monalisa Mondal, Alice Wang, Martina Dicker, Elena Lopez-Guadamillas, Ting-Fang Chou, Nicola A Dobbs, Louisa Essame, Gary Acton, Fiona Kelly, Gavin Halbert, Joseph J Sacco, Andrew Graeme Schache, Richard J Shaw, James Anthony McCaul, Claire Paterson, Joseph H Davies, Peter A Brennan, Rabindra P Singh, Paul M Loadman, William Wilson, Allan Hackshaw, Grégory Seumois, Klaus Okkenhaug, Gareth J Thomas, Terry M Jones, Ferhat Ay, Greg Friberg, Mitchell Kronenberg, Bart Vanhaesebroeck, Pandurangan Vijayanand, Christian Hermann Ottensmeier
Intermittent PI3Kδ inhibition sustains anti-tumour immunity and curbs irAEs. Nature 605 (7911) (2022)
Charlotte J Imianowski, Sarah K Whiteside, Teresa Lozano, Alexander C Evans, Jayme D Benson, Christina J F Courreges, Firas Sadiyah, Colleen M Lau, Nordin D Zandhuis, Francis M Grant, Martijn J Schuijs, Panagiota Vardaka, Paula Kuo, Elizabeth J Soilleux, Jie Yang, Joseph C Sun, Tomohiro Kurosaki, Klaus Okkenhaug, Timotheus Y F Halim, Rahul Roychoudhuri
BACH2 restricts NK cell maturation and function, limiting immunity to cancer metastasis. The Journal of experimental medicine 219 (12) (2022)
Kristoffer Haurum Johansen, Dominic P Golec, Bonnie Huang, Chung Park, Julie H Thomsen, Silvia Preite, Jennifer L Cannons, Fabien Garçon, Edward C Schrom, Christina J F Courreges, Tibor Z Veres, James Harrison, Meritxell Nus, James D Phelan, Wolfgang Bergmeier, John H Kehrl, Klaus Okkenhaug, Pamela L Schwartzberg
A CRISPR screen targeting PI3K effectors identifies RASA3 as a negative regulator of LFA-1-mediated adhesion in T cells. Science signaling 15 (743) (2022)
Sarah K Whiteside, Francis M Grant, David S Gyori, Alberto G Conti, Charlotte J Imianowski, Paula Kuo, Rabab Nasrallah, Firas Sadiyah, Sergio A Lira, Frank Tacke, Robert L Eil, Oliver T Burton, James Dooley, Adrian Liston, Klaus Okkenhaug, Jie Yang, Rahul Roychoudhuri
CCR8 marks highly suppressive Treg cells within tumours but is dispensable for their accumulation and suppressive function. Immunology 163 (4) (2021)
Klaus Okkenhaug
How to resist PI3Kδ inhibition: activate MAPK! Blood 138 (1) (2021)
Bart Vanhaesebroeck, Matthew W D Perry, Jennifer R Brown, Fabrice Andre, Klaus Okkenhaug
PI3K inhibitors are finally coming of age. Nature reviews. Drug discovery 20 (10) (2021)
Chiara Pantarelli, Dingxin Pan, Stephen Chetwynd, Anne-Katrien Stark, Kirsti Hornigold, Polly A Machin, Laraine Crossland, Simon J Cleary, Martin J Baker, Elizabeth Hampson, Anna Mandel, Anne Segonds-Pichon, Rachael Walker, Cornelis van 't Veer, Yanira Riffo-Vasquez, Klaus Okkenhaug, Simon C Pitchford, Heidi C E Welch
The GPCR adaptor protein norbin suppresses the neutrophil-mediated immunity of mice to pneumococcal infection. Blood advances 5 (16) (2021)
Bart Nieuwenhuis, Amanda C Barber, Rachel S Evans, Craig S Pearson, Joachim Fuchs, Amy R MacQueen, Susan van Erp, Barbara Haenzi, Lianne A Hulshof, Andrew Osborne, Raquel Conceicao, Tasneem Z Khatib, Sarita S Deshpande, Joshua Cave, Charles Ffrench-Constant, Patrice D Smith, Klaus Okkenhaug, Britta J Eickholt, Keith R Martin, James W Fawcett, Richard Eva
PI 3-kinase delta enhances axonal PIP3 to support axon regeneration in the adult CNS. EMBO molecular medicine 12 (8) (2020)
Bidesh Mahata, Jhuma Pramanik, Louise van der Weyden, Krzysztof Polański, Gozde Kar, Angela Riedel, Xi Chen, Nuno A Fonseca, Kousik Kundu, Lia S Campos, Edward J Ryder, Graham Duddy, Izabela Walczak, Klaus Okkenhaug, David J Adams, Jacqueline D Shields, Sarah A Teichmann
Tumors induce de novo steroid biosynthesis in T cells to evade immunity. Nature communications 11 (1) (2020)
Anne-Katrien Stark, Elizabeth C M Davenport, Daniel T Patton, Cheryl L Scudamore, Bart Vanhaesebroeck, Marc Veldhoen, Oliver A Garden, Klaus Okkenhaug
Loss of Phosphatidylinositol 3-Kinase Activity in Regulatory T Cells Leads to Neuronal Inflammation. Journal of immunology (Baltimore, Md. : 1950) 205 (1) (2020)
Alberta Iacono, Andrea Pompa, Francesca De Marchis, Eleonora Panfili, Francesco A Greco, Alice Coletti, Ciriana Orabona, Claudia Volpi, Maria L Belladonna, Giada Mondanelli, Elisa Albini, Carmine Vacca, Marco Gargaro, Francesca Fallarino, Roberta Bianchi, Carine De Marcos Lousa, Emilia Mc Mazza, Silvio Bicciato, Elisa Proietti, Francesca Milano, Maria P Martelli, Ioana M Iamandii, Mariona Graupera Garcia-Mila, Judith Llena Sopena, Phillip Hawkins, Sabine Suire, Klaus Okkenhaug, Anne-Katrien Stark, Fabio Grassi, Michele Bellucci, Paolo Puccetti, Laura Santambrogio, Antonio Macchiarulo, Ursula Grohmann, Maria T Pallotta
Class IA PI3Ks regulate subcellular and functional dynamics of IDO1. EMBO reports 21 (12) (2020)
Jack A Bibby, Harriet A Purvis, Thomas Hayday, Anita Chandra, Klaus Okkenhaug, Sofia Rosenzweig, Ivona Aksentijevich, Michael Wood, Helen J Lachmann, Claudia Kemper, Andrew P Cope, Esperanza Perucha
Cholesterol metabolism drives regulatory B cell IL-10 through provision of geranylgeranyl pyrophosphate. Nature communications 11 (1) (2020)
Ee Lyn Lim, Klaus Okkenhaug
Phosphoinositide 3-kinase δ is a regulatory T-cell target in cancer immunotherapy. Immunology 157 (3) (2019)
Stalin Chellappa, Kushi Kushekhar, Ludvig A Munthe, Geir E Tjønnfjord, Einar Martin Aandahl, Klaus Okkenhaug, Kjetil Taskén
The PI3K p110δ Isoform Inhibitor Idelalisib Preferentially Inhibits Human Regulatory T Cell Function. Journal of immunology (Baltimore, Md. : 1950) 202 (5) (2019)
Anne-Katrien Stark, Anita Chandra, Krishnendu Chakraborty, Rafeah Alam, Valentina Carbonaro, Jonathan Clark, Srividya Sriskantharajah, Glyn Bradley, Alex G Richter, Edward Banham-Hall, Menna R Clatworthy, Sergey Nejentsev, J Nicole Hamblin, Edith M Hessel, Alison M Condliffe, Klaus Okkenhaug
PI3Kδ hyper-activation promotes development of B cells that exacerbate Streptococcus pneumoniae infection in an antibody-independent manner. Nature communications 9 (1) (2018)
Hend Abdelrasoul, Markus Werner, Corinna S Setz, Klaus Okkenhaug, Hassan Jumaa
PI3K induces B-cell development and regulates B cell identity. Scientific reports 8 (1) (2018)
Fabien Garçon, Klaus Okkenhaug
PI3Kδ promotes CD4(+) T-cell interactions with antigen-presenting cells by increasing LFA-1 binding to ICAM-1. Immunology and cell biology 94 (5) (2016)
Verity Q Pearce, Hicham Bouabe, Amy R MacQueen, Valentina Carbonaro, Klaus Okkenhaug
PI3Kδ Regulates the Magnitude of CD8+ T Cell Responses after Challenge with Listeria monocytogenes. Journal of immunology (Baltimore, Md. : 1950) 195 (7) (2015)

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Publication Activity (10 Years)

Top Topics

Top Venues

Klaus Okkenhaug