Lewis E Kay

Publication Activity (10 Years)

Years Active: 2016-2024
Publications (10 Years): 50

Top Topics

Molecular Dynamics Simulations

Heat Shock Protein

Top Venues

Journal of the American Chemical Society

Proceedings of the National Academy of Sciences of the United States of America

This page only lists publications with an associated author ORCID identifier.

Publications

Rashik Ahmed, Mingyang Liang, Rhea P Hudson, Atul K Rangadurai, Shuya Kate Huang, Julie Deborah Forman-Kay, Lewis E Kay
Atomic resolution map of the solvent interactions driving SOD1 unfolding in CAPRIN1 condensates. Proceedings of the National Academy of Sciences of the United States of America 121 (35) (2024)
Rashik Ahmed, Mingyang Liang, Rhea P Hudson, Atul K Rangadurai, Shuya Kate Huang, Julie Deborah Forman-Kay, Lewis E Kay
Atomic resolution map of the solvent interactions driving SOD1 unfolding in CAPRIN1 condensates. Proceedings of the National Academy of Sciences of the United States of America 121 (35) (2024)
Binhan Yu, Nicolas Bolik-Coulon, Atul K Rangadurai, Lewis E Kay, Junji Iwahara
Gadolinium-Based NMR Spin Relaxation Measurements of Near-Surface Electrostatic Potentials of Biomolecules. Journal of the American Chemical Society 146 (30) (2024)
Shuya Kate Huang, John L Rubinstein, Lewis E Kay
Cryo-EM of the Nucleosome Core Particle Bound to Ran-RCC1 Reveals a Dynamic Complex. Biochemistry 63 (7) (2024)
Binhan Yu, Nicolas Bolik-Coulon, Atul K Rangadurai, Lewis E Kay, Junji Iwahara
Gadolinium-Based NMR Spin Relaxation Measurements of Near-Surface Electrostatic Potentials of Biomolecules. Journal of the American Chemical Society 146 (30) (2024)
Rashik Ahmed, Mingyang Liang, Rhea P Hudson, Atul K Rangadurai, Shuya Kate Huang, Julie Deborah Forman-Kay, Lewis E Kay
Atomic resolution map of the solvent interactions driving SOD1 unfolding in CAPRIN1 condensates. Proceedings of the National Academy of Sciences of the United States of America 121 (35) (2024)
Atul K Rangadurai, Lisa Ruetz, Rashik Ahmed, Kristen Lo, Martin Tollinger, Julie Deborah Forman-Kay, Christoph Kreutz, Lewis E Kay
Phase Separation Modulates the Thermodynamics and Kinetics of RNA Hybridization. Journal of the American Chemical Society 146 (29) (2024)
Shuya Kate Huang, John L Rubinstein, Lewis E Kay
Cryo-EM of the Nucleosome Core Particle Bound to Ran-RCC1 Reveals a Dynamic Complex. Biochemistry (2024)
Shuya Kate Huang, John L Rubinstein, Lewis E Kay
Cryo-EM of the Nucleosome Core Particle Bound to Ran-RCC1 Reveals a Dynamic Complex. Biochemistry 63 (7) (2024)
Binhan Yu, Nicolas Bolik-Coulon, Atul K Rangadurai, Lewis E Kay, Junji Iwahara
Gadolinium-Based NMR Spin Relaxation Measurements of Near-Surface Electrostatic Potentials of Biomolecules. Journal of the American Chemical Society (2024)
Robert W Harkness, Huaying Zhao, Yuki Toyama, Peter W Schuck, Lewis E Kay
Exploring Host-Guest Interactions within a 600 kDa DegP Protease Cage Complex Using Hydrodynamics Measurements and Methyl-TROSY NMR. Journal of the American Chemical Society 146 (12) (2024)
Atul K Rangadurai, Lisa Ruetz, Rashik Ahmed, Kristen Lo, Martin Tollinger, Julie Deborah Forman-Kay, Christoph Kreutz, Lewis E Kay
Phase Separation Modulates the Thermodynamics and Kinetics of RNA Hybridization. Journal of the American Chemical Society 146 (29) (2024)
Shuya Kate Huang, John L Rubinstein, Lewis E Kay
Cryo-EM of the Nucleosome Core Particle Bound to Ran-RCC1 Reveals a Dynamic Complex. Biochemistry 63 (7) (2024)
Robert W Harkness, Huaying Zhao, Yuki Toyama, Peter W Schuck, Lewis E Kay
Exploring Host-Guest Interactions within a 600 kDa DegP Protease Cage Complex Using Hydrodynamics Measurements and Methyl-TROSY NMR. Journal of the American Chemical Society 146 (12) (2024)
Robert W Harkness, Huaying Zhao, Yuki Toyama, Peter W Schuck, Lewis E Kay
Exploring Host-Guest Interactions within a 600 kDa DegP Protease Cage Complex Using Hydrodynamics Measurements and Methyl-TROSY NMR. Journal of the American Chemical Society (2024)
Robert W Harkness, Huaying Zhao, Yuki Toyama, Peter W Schuck, Lewis E Kay
Exploring Host-Guest Interactions within a 600 kDa DegP Protease Cage Complex Using Hydrodynamics Measurements and Methyl-TROSY NMR. Journal of the American Chemical Society 146 (12) (2024)
Rashik Ahmed, Mingyang Liang, Rhea P Hudson, Atul K Rangadurai, Shuya Kate Huang, Julie Deborah Forman-Kay, Lewis E Kay
Atomic resolution map of the solvent interactions driving SOD1 unfolding in CAPRIN1 condensates. Proceedings of the National Academy of Sciences of the United States of America 121 (35) (2024)
Atul K Rangadurai, Lisa Ruetz, Rashik Ahmed, Kristen Lo, Martin Tollinger, Julie Deborah Forman-Kay, Christoph Kreutz, Lewis E Kay
Phase Separation Modulates the Thermodynamics and Kinetics of RNA Hybridization. Journal of the American Chemical Society (2024)
Binhan Yu, Nicolas Bolik-Coulon, Atul K Rangadurai, Lewis E Kay, Junji Iwahara
Gadolinium-Based NMR Spin Relaxation Measurements of Near-Surface Electrostatic Potentials of Biomolecules. Journal of the American Chemical Society 146 (30) (2024)
Enrico Rennella, Danny D Sahtoe, Julien S Baker, Lewis E Kay
Exploiting conformational dynamics to modulate the function of designed proteins. Proceedings of the National Academy of Sciences of the United States of America 120 (18) (2023)
Enrico Rennella, Danny D Sahtoe, Julien S Baker, Lewis E Kay
Exploiting conformational dynamics to modulate the function of designed proteins. Proceedings of the National Academy of Sciences of the United States of America 120 (18) (2023)
Robert W Harkness, Zev A Ripstein, Justin M Di Trani, Lewis E Kay
Flexible Client-Dependent Cages in the Assembly Landscape of the Periplasmic Protease-Chaperone DegP. Journal of the American Chemical Society (2023)
Enrico Rennella, Danny D Sahtoe, Julien S Baker, Lewis E Kay
Exploiting conformational dynamics to modulate the function of designed proteins. Proceedings of the National Academy of Sciences of the United States of America 120 (18) (2023)
Alexander I M Sever, T Reid Alderson, Enrico Rennella, James M Aramini, Zi Hao Liu, Robert W Harkness, Lewis E Kay
Activation of caspase-9 on the apoptosome as studied by methyl-TROSY NMR. Proceedings of the National Academy of Sciences of the United States of America 120 (51) (2023)
Enrico Rennella, Danny D Sahtoe, Julien S Baker, Lewis E Kay
Exploiting conformational dynamics to modulate the function of designed proteins. Proceedings of the National Academy of Sciences of the United States of America 120 (18) (2023)
Enrico Rennella, Danny D Sahtoe, Julien S Baker, Lewis E Kay
Exploiting conformational dynamics to modulate the function of designed proteins. Proceedings of the National Academy of Sciences of the United States of America 120 (18) (2023)
Enrico Rennella, Danny D Sahtoe, Julien S Baker, Lewis E Kay
Exploiting conformational dynamics to modulate the function of designed proteins. Proceedings of the National Academy of Sciences of the United States of America 120 (18) (2023)
Enrico Rennella, Danny D Sahtoe, Julien S Baker, Lewis E Kay
Exploiting conformational dynamics to modulate the function of designed proteins. Proceedings of the National Academy of Sciences of the United States of America 120 (18) (2023)
Enrico Rennella, Danny D Sahtoe, Julien S Baker, Lewis E Kay
Exploiting conformational dynamics to modulate the function of designed proteins. Proceedings of the National Academy of Sciences of the United States of America 120 (18) (2023)
Nicolas Bolik-Coulon, D Flemming Hansen, Lewis E Kay
Optimizing frequency sampling in CEST experiments. Journal of biomolecular NMR 76 (5-6) (2022)
Zev A Ripstein, Siavash Vahidi, Walid A Houry, John L Rubinstein, Lewis E Kay
A processive rotary mechanism couples substrate unfolding and proteolysis in the ClpXP degradation machinery. eLife 9 (2020)
Zev A Ripstein, Siavash Vahidi, John L Rubinstein, Lewis E Kay
A pH-Dependent Conformational Switch Controls N. meningitidis ClpP Protease Function. Journal of the American Chemical Society 142 (49) (2020)
Leo E Wong, Tae Hun Kim, Enrico Rennella, Pramodh Vallurupalli, Lewis E Kay
Confronting the Invisible: Assignment of Protein 1HN Chemical Shifts in Cases of Extreme Broadening. The journal of physical chemistry letters 11 (9) (2020)
Rui Huang, Zev A Ripstein, John L Rubinstein, Lewis E Kay
Probing Cooperativity of N-Terminal Domain Orientations in the p97 Molecular Machine: Synergy Between NMR Spectroscopy and Cryo-EM. Angewandte Chemie (International ed. in English) 59 (50) (2020)
Leo E Wong, Tae Hun Kim, D Ranjith Muhandiram, Julie Deborah Forman-Kay, Lewis E Kay
NMR Experiments for Studies of Dilute and Condensed Protein Phases: Application to the Phase-Separating Protein CAPRIN1. Journal of the American Chemical Society 142 (5) (2020)
Lewis E Kay, Rui Huang, Pramodh Vallurupalli, Lewis E Kay
A Methyl-TROSY-Based 1 H Relaxation Dispersion Experiment for Studies of Conformational Exchange in High Molecular Weight Proteins. Angewandte Chemie (International ed. in English) 58 (19) (2019)
Enrico Rennella, Gareth J Morgan, Nicholas Yan, Jeffrey W Kelly, Lewis E Kay
The Role of Protein Thermodynamics and Primary Structure in Fibrillogenesis of Variable Domains from Immunoglobulin Light Chains. Journal of the American Chemical Society 141 (34) (2019)
Lewis E Kay, Lewis E Kay
Revisiting 1HN CPMG relaxation dispersion experiments: a simple modification can eliminate large artifacts. Journal of biomolecular NMR 73 (10-11) (2019)
Lewis E Kay, Ashok Sekhar, Andrew J Baldwin, Pramodh Vallurupalli, Lewis E Kay
Measuring Diffusion Constants of Invisible Protein Conformers by Triple-Quantum 1 H CPMG Relaxation Dispersion. Angewandte Chemie (International ed. in English) 57 (51) (2018)
Julianne L Kitevski-LeBlanc, Lewis E Kay, Pamela N Dyer, Johannes Rudolph, Karolin Luger, Lewis E Kay
Investigating the Dynamics of Destabilized Nucleosomes Using Methyl-TROSY NMR. Journal of the American Chemical Society 140 (14) (2018)
Lewis E Kay, Jacob P Brady, Lewis E Kay
Probing Conformational Exchange in Weakly Interacting, Slowly Exchanging Protein Systems via Off-Resonance R1ρ Experiments: Application to Studies of Protein Phase Separation. Journal of the American Chemical Society 140 (6) (2018)
Ashok Sekhar, Algirdas Velyvis, Guy Zoltsman, Rina Rosenzweig, Guillaume Bouvignies, Lewis E Kay
Conserved conformational selection mechanism of Hsp70 chaperone-substrate interactions. eLife 7 (2018)
Lewis E Kay, Lewis E Kay, Guillaume Bouvignies
Dramatic Decrease in CEST Measurement Times Using Multi-Site Excitation. Chemphyschem : a European journal of chemical physics and physical chemistry 19 (14) (2018)
Lewis E Kay, Lewis E Kay
A new class of CEST experiment based on selecting different magnetization components at the start and end of the CEST relaxation element: an application to 1H CEST. Journal of biomolecular NMR 70 (2) (2018)
Lewis E Kay, Alaji Bah, Jacob P Brady, Fabien Ferrage, Guillaume Bouvignies, Lewis E Kay
Measuring Solvent Hydrogen Exchange Rates by Multifrequency Excitation 15N CEST: Application to Protein Phase Separation. The journal of physical chemistry. B 122 (49) (2018)
Julianne Kitevski-LeBlanc, Amelie Fradet-Turcotte, Predrag Kukic, Marcus D Wilson, Guillem Portella, Lewis E Kay, Stephanie Panier, Shili Duan, Marella D Canny, Hugo van Ingen, Cheryl H Arrowsmith, John L Rubinstein, Christopher M Dobson, Daniel Durocher, Lewis E Kay
The RNF168 paralog RNF169 defines a new class of ubiquitylated histone reader involved in the response to DNA damage. eLife 6 (2017)
Rui Huang, Jacob P Brady, Ashok Sekhar, Lewis E Kay, Lewis E Kay
An enhanced sensitivity methyl 1H triple-quantum pulse scheme for measuring diffusion constants of macromolecules. Journal of biomolecular NMR 68 (4) (2017)
Rina Rosenzweig, Ashok Sekhar, Jayashree Nagesh, Lewis E Kay
Promiscuous binding by Hsp70 results in conformational heterogeneity and fuzzy chaperone-substrate ensembles. eLife 6 (2017)
Zev A Ripstein, Rui Huang, Rafal Augustyniak, Lewis E Kay, John L Rubinstein
Structure of a AAA+ unfoldase in the process of unfolding substrate. eLife 6 (2017)
Anne K Schuetz, Lewis E Kay
A Dynamic molecular basis for malfunction in disease mutants of p97/VCP. eLife 5 (2016)