John L Rubinstein

Scopus Author ID ORCID

Publication Activity (10 Years)

Years Active: 2016-2024
Publications (10 Years): 59

Top Venues

Proceedings of the National Academy of Sciences of the United States of America

eLife

Nature communications

Science (New York, N.Y.)

University of Toronto

University of Cambridge (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

University of Toronto Jul 01 2014

Canada

Professor :: Biochemistry and Medical Biophysics

Hospital for Sick Children Jan 01 2013

Canada

Senior Scientist :: Molecular Structure and Function

University of Toronto Jul 01 2012 - Jul 01 2014

Canada

Associate Professor :: Biochemistry and Medical Biophysics

Hospital for Sick Children Jan 01 2006 - Dec 31 2012

Canada

Scientist :: Structural Biology and Biochemistry

University of Toronto Jan 01 2010 - Jul 01 2012

Canada

Assistant Professor :: Medical Biophysics

University of Toronto Jan 01 2006 - Jul 01 2012

Canada

Assistant Professor :: Biochemistry

University of Toronto Oct 01 2003 - Dec 31 2005

Canada

NCIC Postdoctoral Fellow :: Banting and Best Department of Medical Research

MRC Laboratory of Molecular Biology Jan 01 2002 - Oct 31 2003

United Kingdom

Postdoctoral Research Associate :: Structural Studies

Education History

University of Cambridge Oct 01 1998 - Mar 01 2002

United Kingdom

PHD :: MRC LMB/MRC DHNU (now known as MRC MBU)

University of Guelph Sep 01 1994 - May 01 1998

Canada

BSC :: College of Engineering and Physical Sciences

Publications

Claire E Coupland, Ryan Karimi, Stephanie A Bueler, Yingke Liang, Gautier M Courbon, Justin M Di Trani, Cassandra J Wong, Rayan Saghian, Ji-Young Youn, Lu-Yang Wang, John L Rubinstein
High-resolution electron cryomicroscopy of V-ATPase in native synaptic vesicles. Science (New York, N.Y.) 385 (6705) (2024)
Duc Minh Nguyen, Deanna H Rath, Dominic Devost, Darlaine Pétrin, Robert Rizk, Alan X Ji, Naveen Narayanan, Darren Yong, Andrew Zhai, Douglas A Kuntz, Maha U Q Mian, Neil C Pomroy, Alexander F A Keszei, Samir Benlekbir, Mohammad T Mazhab-Jafari, John L Rubinstein, Terence E Hébert, Gilbert G Privé
Structure and dynamics of a pentameric KCTD5/CUL3/Gβγ E3 ubiquitin ligase complex. Proceedings of the National Academy of Sciences of the United States of America 121 (17) (2024)
Duc Minh Nguyen, Deanna H Rath, Dominic Devost, Darlaine Pétrin, Robert Rizk, Alan X Ji, Naveen Narayanan, Darren Yong, Andrew Zhai, Douglas A Kuntz, Maha U Q Mian, Neil C Pomroy, Alexander F A Keszei, Samir Benlekbir, Mohammad T Mazhab-Jafari, John L Rubinstein, Terence E Hébert, Gilbert G Privé
Structure and dynamics of a pentameric KCTD5/CUL3/Gβγ E3 ubiquitin ligase complex. Proceedings of the National Academy of Sciences of the United States of America 121 (17) (2024)
Shuya Kate Huang, John L Rubinstein, Lewis E Kay
Cryo-EM of the Nucleosome Core Particle Bound to Ran-RCC1 Reveals a Dynamic Complex. Biochemistry 63 (7) (2024)
Shuya Kate Huang, John L Rubinstein, Lewis E Kay
Cryo-EM of the Nucleosome Core Particle Bound to Ran-RCC1 Reveals a Dynamic Complex. Biochemistry (2024)
Shuya Kate Huang, John L Rubinstein, Lewis E Kay
Cryo-EM of the Nucleosome Core Particle Bound to Ran-RCC1 Reveals a Dynamic Complex. Biochemistry 63 (7) (2024)
Hanlin Wang, Maureen Tarsio, Patricia M Kane, John L Rubinstein
Structure of yeast RAVE bound to a partial V 1 complex. bioRxiv : the preprint server for biology (2024)
Shuya Kate Huang, John L Rubinstein, Lewis E Kay
Cryo-EM of the Nucleosome Core Particle Bound to Ran-RCC1 Reveals a Dynamic Complex. Biochemistry 63 (7) (2024)
Duc Minh Nguyen, Deanna H Rath, Dominic Devost, Darlaine Pétrin, Robert Rizk, Alan X Ji, Naveen Narayanan, Darren Yong, Andrew Zhai, Douglas A Kuntz, Maha U Q Mian, Neil C Pomroy, Alexander F A Keszei, Samir Benlekbir, Mohammad T Mazhab-Jafari, John L Rubinstein, Terence E Hébert, Gilbert G Privé
Structure and dynamics of a pentameric KCTD5/CUL3/Gβγ E3 ubiquitin ligase complex. Proceedings of the National Academy of Sciences of the United States of America 121 (17) (2024)
Claire E Coupland, Ryan Karimi, Stephanie A Bueler, Yingke Liang, Gautier M Courbon, Justin M Di Trani, Cassandra J Wong, Rayan Saghian, Ji-Young Youn, Lu-Yang Wang, John L Rubinstein
High-resolution electron cryomicroscopy of V-ATPase in native synaptic vesicles. Science (New York, N.Y.) 385 (6705) (2024)
Ana Paula Lobez, Fei Wu, Justin M Di Trani, John L Rubinstein, Mikael Oliveberg, Peter Brzezinski, Agnes Moe
Electron transfer in the respiratory chain at low salinity. Nature communications 15 (1) (2024)
Claire E Coupland, Ryan Karimi, Stephanie A Bueler, Yingke Liang, Gautier M Courbon, Justin M Di Trani, Cassandra J Wong, Rayan Saghian, Ji-Young Youn, Lu-Yang Wang, John L Rubinstein
High-resolution electron cryomicroscopy of V-ATPase in native synaptic vesicles. Science (New York, N.Y.) (2024)
Duc Minh Nguyen, Deanna H Rath, Dominic Devost, Darlaine Pétrin, Robert Rizk, Alan X Ji, Naveen Narayanan, Darren Yong, Andrew Zhai, Douglas A Kuntz, Maha U Q Mian, Neil C Pomroy, Alexander F A Keszei, Samir Benlekbir, Mohammad T Mazhab-Jafari, John L Rubinstein, Terence E Hébert, Gilbert G Privé
Structure and dynamics of a pentameric KCTD5/CUL3/Gβγ E3 ubiquitin ligase complex. Proceedings of the National Academy of Sciences of the United States of America 121 (17) (2024)
Hanlin Wang, Stephanie A Bueler, John L Rubinstein
Structural basis of V-ATPase V O region assembly by Vma12p, 21p, and 22p. Proceedings of the National Academy of Sciences of the United States of America 120 (6) (2023)
Yingke Liang, John L Rubinstein
Structural analysis of mycobacterial electron transport chain complexes by cryoEM. Biochemical Society transactions 51 (1) (2023)
Hanlin Wang, Stephanie A Bueler, John L Rubinstein
Structural basis of V-ATPase V O region assembly by Vma12p, 21p, and 22p. Proceedings of the National Academy of Sciences of the United States of America 120 (6) (2023)
Clare Burn Aschner, Krithika Muthuraman, Iga Kucharska, Hong Cui, Katherine Prieto, Manoj S Nair, Maple Wang, Yaoxing Huang, Natasha Christie-Holmes, Betty Poon, Jessica Lam, Azmiri Sultana, Robert Kozak, Samira Mubareka, John L Rubinstein, Edurne Rujas, Bebhinn Treanor, David D Ho, Arif Jetha, Jean-Philippe Julien
A multi-specific, multi-affinity antibody platform neutralizes sarbecoviruses and confers protection against SARS-CoV-2 in vivo. Science translational medicine 15 (697) (2023)
Hanlin Wang, Stephanie A Bueler, John L Rubinstein
Structural basis of V-ATPase V O region assembly by Vma12p, 21p, and 22p. Proceedings of the National Academy of Sciences of the United States of America 120 (6) (2023)
Gautier M Courbon, Paul R Palme, Lea Mann, Adrian Richter, Peter Imming, John L Rubinstein
Mechanism of mycobacterial ATP synthase inhibition by squaramides and second generation diarylquinolines. The EMBO journal (2023)
Justin M Di Trani, Andreea A Gheorghita, Madison Turner, Peter Brzezinski, Pia Ädelroth, Siavash Vahidi, P Lynne Howell, John L Rubinstein
Structure of the bc 1 - cbb 3 respiratory supercomplex from Pseudomonas aeruginosa . Proceedings of the National Academy of Sciences of the United States of America 120 (40) (2023)
Yingke Liang, Alicia Plourde, Stephanie A Bueler, Jun Liu, Peter Brzezinski, Siavash Vahidi, John L Rubinstein
Structure of mycobacterial respiratory complex I. Proceedings of the National Academy of Sciences of the United States of America 120 (13) (2023)
Hanlin Wang, Stephanie A Bueler, John L Rubinstein
Structural basis of V-ATPase V O region assembly by Vma12p, 21p, and 22p. Proceedings of the National Academy of Sciences of the United States of America 120 (6) (2023)
Rana Abdelaziz, Justin M Di Trani, Henok Sahile, Lea Mann, Adrian Richter, Zhongle Liu, Stephanie A Bueler, Leah E Cowen, John L Rubinstein, Peter Imming
Imidazopyridine Amides: Synthesis, Mycobacterium smegmatis CIII 2 CIV 2 Supercomplex Binding, and In Vitro Antimycobacterial Activity. ACS omega 8 (21) (2023)
Hanlin Wang, Stephanie A Bueler, John L Rubinstein
Structural basis of V-ATPase V O region assembly by Vma12p, 21p, and 22p. Proceedings of the National Academy of Sciences of the United States of America 120 (6) (2023)
Yingke Liang, Alicia Plourde, Stephanie A Bueler, Jun Liu, Peter Brzezinski, Siavash Vahidi, John L Rubinstein
Structure of mycobacterial respiratory complex I. Proceedings of the National Academy of Sciences of the United States of America 120 (13) (2023)
Yingke Liang, John L Rubinstein
Structural analysis of mycobacterial electron transport chain complexes by cryoEM. Biochemical Society transactions (2023)
Yingke Liang, John L Rubinstein
Structural analysis of mycobacterial electron transport chain complexes by cryoEM. Biochemical Society transactions 51 (1) (2023)
Hanlin Wang, Stephanie A Bueler, John L Rubinstein
Structural basis of V-ATPase V O region assembly by Vma12p, 21p, and 22p. Proceedings of the National Academy of Sciences of the United States of America 120 (6) (2023)
Hui Guo, John L Rubinstein
Structure of ATP synthase under strain during catalysis. Nature communications 13 (1) (2022)
Justin M Di Trani, Agnes Moe, Daniel Riepl, Patricia Saura, Ville R I Kaila, Peter Brzezinski, John L Rubinstein
Structural basis of mammalian complex IV inhibition by steroids. Proceedings of the National Academy of Sciences of the United States of America 119 (30) (2022)
Kristine A Keon, Samir Benlekbir, Susanne H Kirsch, Daniel Krug, John L Rubinstein
Cryo-EM of the Yeast V O Complex Reveals Distinct Binding Sites for Macrolide V-ATPase Inhibitors. ACS chemical biology 17 (3) (2022)
Michelle E Maxson, Yazan M Abbas, Jing Ze Wu, Jonathan D Plumb, Sergio Grinstein, John L Rubinstein
Detection and quantification of the vacuolar H+ATPase using the Legionella effector protein SidK. The Journal of cell biology 221 (3) (2022)
Thamiya Vasanthakumar, Kristine A Keon, Stephanie A Bueler, Michael C Jaskolka, John L Rubinstein
Coordinated conformational changes in the V 1 complex during V-ATPase reversible dissociation. Nature structural & molecular biology 29 (5) (2022)
Yong Zi Tan, Yazan M Abbas, Jing Ze Wu, Di Wu, Kristine A Keon, Geoffrey G Hesketh, Stephanie A Bueler, Anne-Claude Gingras, Carol V Robinson, Sergio Grinstein, John L Rubinstein
CryoEM of endogenous mammalian V-ATPase interacting with the TLDc protein mEAK-7. Life science alliance 5 (11) (2022)
Iga Kucharska, Lamia Hossain, Danton Ivanochko, Qiren Yang, John L Rubinstein, Régis Pomès, Jean-Philippe Julien
Structural basis of Plasmodium vivax inhibition by antibodies binding to the circumsporozoite protein repeats. eLife 11 (2022)
Hui Guo, John L Rubinstein
Author Correction: Structure of ATP synthase under strain during catalysis. Nature communications 13 (1) (2022)
Bhairavi Tolani, Anna Celli, Yanmin Yao, Yong Zi Tan, Richard Fetter, Christina R Liem, Adam J de Smith, Thamiya Vasanthakumar, Paola Bisignano, Adam D Cotton, Ian B Seiple, John L Rubinstein, Marco Jost, Jonathan S Weissman
Ras-mutant cancers are sensitive to small molecule inhibition of V-type ATPases in mice. Nature biotechnology (2022)
Edurne Rujas, Iga Kucharska, Yong Zi Tan, Samir Benlekbir, Hong Cui, Tiantian Zhao, Gregory A Wasney, Patrick Budylowski, Furkan Guvenc, Jocelyn C Newton, Taylor Sicard, Anthony Semesi, Krithika Muthuraman, Amy Nouanesengsy, Clare Burn Aschner, Katherine Prieto, Stephanie A Bueler, Sawsan Youssef, Sindy Liao-Chan, Jacob Glanville, Natasha Christie-Holmes, Samira Mubareka, Scott D Gray-Owen, John L Rubinstein, Bebhinn Treanor, Jean-Philippe Julien
Multivalency transforms SARS-CoV-2 antibodies into ultrapotent neutralizers. Nature communications 12 (1) (2021)
Agnes Moe, Justin Di Trani, John L Rubinstein, Peter Brzezinski
Cryo-EM structure and kinetics reveal electron transfer by 2D diffusion of cytochrome c in the yeast III-IV respiratory supercomplex. Proceedings of the National Academy of Sciences of the United States of America 118 (11) (2021)
David J Yanofsky, Justin M Di Trani, Sylwia Król, Rana Abdelaziz, Stephanie A Bueler, Peter Imming, Peter Brzezinski, John L Rubinstein
Structure of mycobacterial CIII2CIV2 respiratory supercomplex bound to the tuberculosis drug candidate telacebec (Q203). eLife 10 (2021)
Sarah C Bickers, Samir Benlekbir, John L Rubinstein, Voula Kanelis
Structure of Ycf1p reveals the transmembrane domain TMD0 and the regulatory region of ABCC transporters. Proceedings of the National Academy of Sciences of the United States of America 118 (21) (2021)
Yazan M Abbas, Di Wu, Stephanie A Bueler, Carol V Robinson, John L Rubinstein
Structure of V-ATPase from the mammalian brain. Science (New York, N.Y.) 367 (6483) (2020)
Yong Zi Tan, John L Rubinstein
Through-grid wicking enables high-speed cryoEM specimen preparation. Acta crystallographica. Section D, Structural biology 76 (Pt 11) (2020)
Zev A Ripstein, Siavash Vahidi, Walid A Houry, John L Rubinstein, Lewis E Kay
A processive rotary mechanism couples substrate unfolding and proteolysis in the ClpXP degradation machinery. eLife 9 (2020)
Hui Guo, Erik Franken, Yuchen Deng, Samir Benlekbir, Garbi Singla Lezcano, Bart Janssen, Lingbo Yu, Zev A Ripstein, Yong Zi Tan, John L Rubinstein
Electron-event representation data enable efficient cryoEM file storage with full preservation of spatial and temporal resolution. IUCrJ 7 (Pt 5) (2020)
Iga Kucharska, Elaine Thai, Ananya Srivastava, John L Rubinstein, Régis Pomès, Jean-Philippe Julien
Structural ordering of the Plasmodium berghei circumsporozoite protein repeats by inhibitory antibody 3D11. eLife 9 (2020)
Hui Guo, Gautier M Courbon, Stephanie A Bueler, Juntao Mai, Jun Liu, John L Rubinstein
Structure of mycobacterial ATP synthase bound to the tuberculosis drug bedaquiline. Nature 589 (7840) (2020)
David Sharon, Severine Cathelin, Sara Mirali, Justin M Di Trani, David J Yanofsky, Kristine A Keon, John L Rubinstein, Aaron D Schimmer, Troy Ketela, Steven M Chan
Inhibition of mitochondrial translation overcomes venetoclax resistance in AML through activation of the integrated stress response. Science translational medicine 11 (516) (2020)
Rui Huang, Zev A Ripstein, John L Rubinstein, Lewis E Kay
Probing Cooperativity of N-Terminal Domain Orientations in the p97 Molecular Machine: Synergy Between NMR Spectroscopy and Cryo-EM. Angewandte Chemie (International ed. in English) 59 (50) (2020)
Zhijie Li, Aidan Ca Tomlinson, Alan Hm Wong, Dongxia Zhou, Marc Desforges, Pierre J Talbot, Samir Benlekbir, John L Rubinstein, James M Rini
The human coronavirus HCoV-229E S-protein structure and receptor binding. eLife 8 (2019)
Hui Guo, Toshiharu Suzuki, John L Rubinstein
Structure of a bacterial ATP synthase. eLife 8 (2019)
John L Rubinstein, Hui Guo, Zev A Ripstein, Ali Haydaroglu, Aaron Au, Christopher M Yip, Justin M Di Trani, Samir Benlekbir, Timothy Kwok
Shake-it-off: a simple ultrasonic cryo-EM specimen-preparation device. Acta crystallographica. Section D, Structural biology 75 (Pt 12) (2019)
Matthew McCallum, Samir Benlekbir, Sheryl Nguyen, Stephanie Tammam, John L Rubinstein, Lori L Burrows, P Lynne Howell
Multiple conformations facilitate PilT function in the type IV pilus. Nature communications 10 (1) (2019)
Benjamin Wiseman, Ram Gopal Nitharwal, Olga Fedotovskaya, Jacob Schäfer, Hui Guo, Qie Kuang, Samir Benlekbir, Dan Sjöstrand, Pia Ädelroth, John L Rubinstein, Peter Brzezinski, Michael Haumann
Structure of a functional obligate complex III2IV2 respiratory supercomplex from Mycobacterium smegmatis. Nature structural & molecular biology 25 (12) (2018)
Ali Punjani, John L Rubinstein, David J Fleet, Marcus A Brubaker
cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination. Nature methods 14 (3) (2017)
Hui Guo, Stephanie A Bueler, John L Rubinstein
Atomic model for the dimeric FO region of mitochondrial ATP synthase. Science (New York, N.Y.) 358 (6365) (2017)
Julianne Kitevski-LeBlanc, Amelie Fradet-Turcotte, Predrag Kukic, Marcus D Wilson, Guillem Portella, Lewis E Kay, Stephanie Panier, Shili Duan, Marella D Canny, Hugo van Ingen, Cheryl H Arrowsmith, John L Rubinstein, Christopher M Dobson, Daniel Durocher, Lewis E Kay
The RNF168 paralog RNF169 defines a new class of ubiquitylated histone reader involved in the response to DNA damage. eLife 6 (2017)
Zev A Ripstein, Rui Huang, Rafal Augustyniak, Lewis E Kay, John L Rubinstein
Structure of a AAA+ unfoldase in the process of unfolding substrate. eLife 6 (2017)
Mohammad T Mazhab-Jafari, John L Rubinstein
Cryo-EM studies of the structure and dynamics of vacuolar-type ATPases. Science advances 2 (7) (2016)

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Publication Activity (10 Years)

Top Topics

Top Venues

John L Rubinstein