Jeffrey W Kelly (Jeffrey Kelly, John M Kelly, Jeffery W Kelly, Jeffery Kelly)

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 44

Top Topics

Multiple Myeloma

Structural Basis

Machine Learning

Endoplasmic Reticulum

Top Venues

bioRxiv : the preprint server for biology

Advances in therapy

Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis

This page only lists publications with an associated author ORCID identifier.

Publications

Mathew S Maurer, Prem Soman, Adrian F Hernandez, Pablo García-Pavía, James E Signorovitch, Lee-Jen Wei, Mazen Hanna, Frederick L Ruberg, Michelle M Kittleson, Dhruv S Kazi, Sharmila Dorbala, Kristen Hsu, Isabelle Lousada, Rosalyn O Adigun, Preston Dunnmon, Jeffrey W Kelly, Julian David Gillmore, null null
Advancing Transthyretin Amyloidosis Drug Development in an Evolving Treatment Landscape: Amyloidosis Forum Meeting Proceedings. Advances in therapy 41 (7) (2024)
Mathew S Maurer, Prem Soman, Adrian F Hernandez, Pablo García-Pavía, James E Signorovitch, Lee-Jen Wei, Mazen Hanna, Frederick L Ruberg, Michelle M Kittleson, Dhruv S Kazi, Sharmila Dorbala, Kristen Hsu, Isabelle Lousada, Rosalyn O Adigun, Preston Dunnmon, Jeffrey W Kelly, Julian David Gillmore, null null
Advancing Transthyretin Amyloidosis Drug Development in an Evolving Treatment Landscape: Amyloidosis Forum Meeting Proceedings. Advances in therapy (2024)
Mathew S Maurer, Prem Soman, Adrian F Hernandez, Pablo García-Pavía, James E Signorovitch, Lee-Jen Wei, Mazen Hanna, Frederick L Ruberg, Michelle M Kittleson, Dhruv S Kazi, Sharmila Dorbala, Kristen Hsu, Isabelle Lousada, Rosalyn O Adigun, Preston Dunnmon, Jeffrey W Kelly, Julian David Gillmore, null null
Advancing Transthyretin Amyloidosis Drug Development in an Evolving Treatment Landscape: Amyloidosis Forum Meeting Proceedings. Advances in therapy 41 (7) (2024)
Mathew S Maurer, Prem Soman, Adrian F Hernandez, Pablo García-Pavía, James E Signorovitch, Lee-Jen Wei, Mazen Hanna, Frederick L Ruberg, Michelle M Kittleson, Dhruv S Kazi, Sharmila Dorbala, Kristen Hsu, Isabelle Lousada, Rosalyn O Adigun, Preston Dunnmon, Jeffrey W Kelly, Julian David Gillmore, null null
Advancing Transthyretin Amyloidosis Drug Development in an Evolving Treatment Landscape: Amyloidosis Forum Meeting Proceedings. Advances in therapy 41 (7) (2024)
Benjamin Basanta, Karina Nugroho, Nicholas L Yan, Gabriel M Kline, Evan T Powers, Felix J Tsai, Mengyu Wu, Althea T Hansel-Harris, Jason S Chen, Stefano Forli, Jeffrey W Kelly, Gabriel C Lander
The conformational landscape of human transthyretin revealed by cryo-EM. bioRxiv : the preprint server for biology (2024)
Benjamin Basanta, Karina Nugroho, Nicholas L Yan, Gabriel M Kline, Evan T Powers, Felix J Tsai, Mengyu Wu, Althea T Hansel-Harris, Jason S Chen, Stefano Forli, Jeffrey W Kelly, Gabriel C Lander
The conformational landscape of human transthyretin revealed by cryo-EM. bioRxiv : the preprint server for biology (2024)
Benjamin Basanta, Karina Nugroho, Nicholas L Yan, Gabriel M Kline, Evan T Powers, Felix J Tsai, Mengyu Wu, Althea T Hansel-Harris, Jason S Chen, Stefano Forli, Jeffrey W Kelly, Gabriel C Lander
The conformational landscape of human transthyretin revealed by cryo-EM. bioRxiv : the preprint server for biology (2024)
Judith Frydman, Ching-Chieh Chou, Ryan Vest, Miguel A Prado, Joshua Wilson-Grady, Joao A Paulo, Yohei Shibuya, Patricia Moran Losada, Ting-Ting Lee, Jian Luo, Steven P Gygi, Jeffrey W Kelly, Daniel Finley, Marius Wernig, Tony Wyss-Coray
Human tNeurons reveal aging-linked proteostasis deficits driving Alzheimer's phenotypes. Research square (2024)
Gabriel M Kline, Nicole Madrazo, Christian M Cole, Meera Pannikkat, Michael J Bollong, Jessica D Rosarda, Jeffrey W Kelly, R Luke Wiseman
Metabolically activated proteostasis regulators that protect against erastin-induced ferroptosis. RSC chemical biology 5 (9) (2024)
Mathew S Maurer, Prem Soman, Adrian F Hernandez, Pablo García-Pavía, James E Signorovitch, Lee-Jen Wei, Mazen Hanna, Frederick L Ruberg, Michelle M Kittleson, Dhruv S Kazi, Sharmila Dorbala, Kristen Hsu, Isabelle Lousada, Rosalyn O Adigun, Preston Dunnmon, Jeffrey W Kelly, Julian David Gillmore, null null
Advancing Transthyretin Amyloidosis Drug Development in an Evolving Treatment Landscape: Amyloidosis Forum Meeting Proceedings. Advances in therapy 41 (7) (2024)
Judith Frydman, Ching-Chieh Chou, Ryan Vest, Miguel A Prado, Joshua Wilson-Grady, Joao A Paulo, Yohei Shibuya, Patricia Moran Losada, Ting-Ting Lee, Jian Luo, Steven P Gygi, Jeffrey W Kelly, Daniel Finley, Marius Wernig, Tony Wyss-Coray
Human tNeurons reveal aging-linked proteostasis deficits driving Alzheimer's phenotypes. Research square (2024)
Ching-Chieh Chou, Ryan Vest, Miguel A Prado, Joshua Wilson-Grady, Joao A Paulo, Yohei Shibuya, Patricia Moran-Losada, Ting-Ting Lee, Jian Luo, Steven P Gygi, Jeffrey W Kelly, Daniel Finley, Marius Wernig, Tony Wyss-Coray, Judith Frydman
Human tNeurons reveal aging-linked proteostasis deficits driving Alzheimer's phenotypes. Research square (2024)
Frederick L Ruberg, William S Blaner, Codruta Chiuzan, Lawreen H Connors, Andrew J Einstein, Denise Fine, Stephen Helmke, Damian Kurian, Shivda Pandey, Farbod Raiszadeh, Carlos Rodriguez, Natalia Sabogal, Sergio Teruya, Morgan Winburn, Wendy K Chung, Elizabeth Cohn, Robert J H Miller, Jeffrey W Kelly, Mathew S Maurer
Design and Rationale the SCAN-MP (Screening for Cardiac Amyloidosis With Nuclear Imaging in Minority Populations) Study. Journal of the American Heart Association (2023)
null null, null null, Suzanne Elsasser, Lisa P Elia, Richard I Morimoto, Evan T Powers, null null, Suzanne Elsasser, Daniel Finley, null null, Beatrice Costa, Maher Budron, Zachary Tokuno, Shijie Wang, Rajshri G Iyer, Bianca Barth, Eric Mockler, Lisa P Elia, Steven Finkbeiner, null null, Jason E Gestwicki, null null, Reese A K Richardson, Thomas Stoeger, Richard I Morimoto, null null, Ee Phie Tan, Qiang Xiao, Christian M Cole, Lynée A Massey, Dan Garza, Evan T Powers, Jeffrey W Kelly, null null, T Kelly Rainbolt, Ching-Chieh Chou, Vincent B Masto, Judith Frydman, null null, Ralph A Nixon
A Comprehensive Enumeration of the Human Proteostasis Network. 2. Components of the Autophagy-Lysosome Pathway. bioRxiv : the preprint server for biology (2023)
Gabriel M Kline, Ryan J Paxman, Chung-Yon Lin, Nicole Madrazo, Julia M Grandjean, Kyunga Lee, Karina Nugroho, Evan T Powers, R Luke Wiseman, Jeffrey W Kelly
Divergent Proteome Reactivity Influences Arm-Selective Activation of Pharmacological Endoplasmic Reticulum Proteostasis Regulators. bioRxiv : the preprint server for biology (2023)
Gabriel M Kline, Ryan J Paxman, Chung-Yon Lin, Nicole Madrazo, Julia M Grandjean, Kyunga Lee, Karina Nugroho, Evan T Powers, R Luke Wiseman, Jeffrey W Kelly
Divergent Proteome Reactivity Influences Arm-Selective Activation of Pharmacological Endoplasmic Reticulum Proteostasis Regulators. bioRxiv : the preprint server for biology (2023)
Felix J Tsai, Marcus Jaeger, Teresa Coelho, Evan T Powers, Jeffrey W Kelly
Tafamidis concentration required for transthyretin stabilisation in cerebrospinal fluid. Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis (2023)
Lina Xie, Marianne E Bowman, Gordon V Louie, Cheng Zhang, Maziar S Ardejani, Xuemei Huang, Qian Chu, Cynthia J Donaldson, Joan M Vaughan, Huanqi Shan, Evan T Powers, Jeffrey W Kelly, Dimitry Lyumkis, Joseph A P Noel, Alan Saghatelian
Biochemistry and Protein Interactions of the CYREN Microprotein. Biochemistry (2023)
Gabriel M Kline, Ryan J Paxman, Chung-Yon Lin, Nicole Madrazo, Leonard Yoon, Julia M D Grandjean, Kyunga Lee, Karina Nugroho, Evan T Powers, R Luke Wiseman, Jeffrey W Kelly
Divergent Proteome Reactivity Influences Arm-Selective Activation of the Unfolded Protein Response by Pharmacological Endoplasmic Reticulum Proteostasis Regulators. ACS chemical biology (2023)
Cecilia Monteiro, Jaleh S Mesgarzadeh, João Anselmo, Joana Fernandes, Marta Novais, Carla Rodrigues, David L Powers, Evan T Powers, Teresa Coelho, Jeffrey W Kelly
Tafamidis polyneuropathy amelioration requires modest increases in transthyretin stability even though increases in plasma native TTR and decreases in non-native TTR do not predict response. Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis (2022)
Felix J Tsai, Luke T Nelson, Gabriel M Kline, Marcus Jäger, John L Berk, Yoshiki Sekijima, Evan T Powers, Jeffrey W Kelly
Characterising diflunisal as a transthyretin kinetic stabilizer at relevant concentrations in human plasma using subunit exchange. Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis (2022)
Nicholas L Yan, Diogo Santos-Martins, Reji N Nair, Alan Chu, Ian A Wilson, Kristen A Johnson, Stefano Forli, Gareth J Morgan, H Michael Petrassi, Jeffrey W Kelly
Discovery of Potent Coumarin-Based Kinetic Stabilizers of Amyloidogenic Immunoglobulin Light Chains Using Structure-Based Design. Journal of medicinal chemistry 64 (9) (2021)
Jeffrey W Kelly
Does protein aggregation drive postmitotic tissue degeneration? Science translational medicine 13 (577) (2021)
Jessica D Rosarda, Kelsey R Baron, Kayla Nutsch, Gabriel M Kline, Caroline Stanton, Jeffrey W Kelly, Michael J Bollong, R Luke Wiseman
Metabolically Activated Proteostasis Regulators Protect against Glutamate Toxicity by Activating NRF2. ACS chemical biology (2021)
Maziar S Ardejani, Louis Noodleman, Evan T Powers, Jeffrey W Kelly
Stereoelectronic effects in stabilizing protein-N-glycan interactions revealed by experiment and machine learning. Nature chemistry 13 (5) (2021)
Luke T Nelson, Ryan J Paxman, Jin Xu, Bill Webb, Evan T Powers, Jeffrey W Kelly
Blinded potency comparison of transthyretin kinetic stabilisers by subunit exchange in human plasma. Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis 28 (1) (2020)
Anvesh K R Dasari, Ivan Hung, Brian Michael, Zhehong Gan, Jeffrey W Kelly, Lawreen H Connors, Robert G Griffin, Kwang Hun Lim
Structural Characterization of Cardiac Ex Vivo Transthyretin Amyloid: Insight into the Transthyretin Misfolding Pathway In Vivo. Biochemistry 59 (19) (2020)
Jeffrey W Kelly, Evan Powers
Response. Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis 28 (2) (2020)
Gabriel J Brighty, Rachel C Botham, Suhua Li, Luke Nelson, David E Mortenson, Gencheng Li, Christophe Morisseau, Hua Wang, Bruce D Hammock, K Barry Sharpless, Jeffrey W Kelly
Using sulfuramidimidoyl fluorides that undergo sulfur(VI) fluoride exchange for inverse drug discovery. Nature chemistry 12 (10) (2020)
Bryan J Lampkin, Cecilia Monteiro, Evan T Powers, Paige M Bouc, Jeffrey W Kelly, Brett VanVeller
A designed protein binding-pocket to control excited-state intramolecular proton transfer fluorescence. Organic & biomolecular chemistry 17 (5) (2019)
Xun Sun, Marcus Jaeger, Jeffrey W Kelly, H Jane Dyson, Peter E Wright
Correction to "Mispacking of the Phe87 Side Chain Reduces the Kinetic Stability of Human Transthyretin". Biochemistry 58 (6) (2019)
Enrico Rennella, Gareth J Morgan, Nicholas Yan, Jeffrey W Kelly, Lewis E Kay
The Role of Protein Thermodynamics and Primary Structure in Fibrillogenesis of Variable Domains from Immunoglobulin Light Chains. Journal of the American Chemical Society 141 (34) (2019)
Ryan J Paxman, Lars Plate, Erik A Blackwood, Chris Glembotski, Evan T Powers, R Luke Wiseman, Jeffrey W Kelly
Pharmacologic ATF6 activating compounds are metabolically activated to selectively modify endoplasmic reticulum proteins. eLife 7 (2018)
Xun Sun, Marcus Jäger, Jeffrey W Kelly, H Jane Dyson, Peter E Wright
Mispacking of the Phe87 Side Chain Reduces the Kinetic Stability of Human Transthyretin. Biochemistry 57 (51) (2018)
Joseph D Schonhoft, Cecilia Monteiro, Lars Plate, Yvonne S Eisele, Jeffrey W Kelly, Daniel Boland, Christopher G Parker, Benjamin F Cravatt, Sergio Teruya, Stephen T Helmke, Mathew S Maurer, John L Berk, Yoshiki Sekijima, Marta Novais, Teresa Coelho, Evan T Powers, Jeffery W Kelly
Peptide probes detect misfolded transthyretin oligomers in plasma of hereditary amyloidosis patients. Science translational medicine 9 (407) (2018)
Jeffrey W Kelly
The two shapes of the Tau protein. eLife 7 (2018)
Heike Kroeger, Neil J Grimsey, Ryan J Paxman, Wei-Chieh Chiang, Lars Plate, Ying Jones, Peter X Shaw, JoAnn Trejo, Stephen H Tsang, Evan T Powers, Jeffrey W Kelly, R Luke Wiseman, Jonathan H Lin
The unfolded protein response regulator ATF6 promotes mesodermal differentiation. Science signaling 11 (517) (2018)
Benjamin I Leach, Zhang Xin, Jeffrey W Kelly, H Jane Dyson, Peter E Wright
NMR Measurements Reveal the Structural Basis of Transthyretin Destabilization by Pathogenic Mutations. Biochemistry 57 (30) (2018)
Michael J Lambrecht, Jeffrey W Kelly, Ryan A Shenvi
Mechanism of Action of the Cytotoxic Asmarine Alkaloids. ACS chemical biology 13 (5) (2018)
Maziar S Ardejani, Evan T Powers, Jeffrey W Kelly
Using Cooperatively Folded Peptides To Measure Interaction Energies and Conformational Propensities. Accounts of chemical research 50 (8) (2017)
Kwang Hun Lim, Anvesh K R Dasari, Renze Ma, Ivan Hung, Zhehong Gan, Jeffrey W Kelly, Michael C Fitzgerald
Pathogenic Mutations Induce Partial Structural Changes in the Native β-Sheet Structure of Transthyretin and Accelerate Aggregation. Biochemistry 56 (36) (2017)
Yen-Wen Huang, Hwai-I Yang, Ying-Ta Wu, Tsui-Ling Hsu, Tzu-Wen Lin, Jeffrey W Kelly, Chi-Huey Wong
Residues Comprising the Enhanced Aromatic Sequon Influence Protein N-Glycosylation Efficiency. Journal of the American Chemical Society 139 (37) (2017)
David E Mortenson, Gabriel J Brighty, Lars Plate, Grant Bare, Wentao Chen, Suhua Li, Hua Wang, Benjamin F Cravatt, Stefano Forli, Evan T Powers, K Barry Sharpless, Ian A Wilson, Jeffrey W Kelly
"Inverse Drug Discovery" Strategy To Identify Proteins That Are Targeted by Latent Electrophiles As Exemplified by Aryl Fluorosulfates. Journal of the American Chemical Society 140 (1) (2017)
Gareth J Morgan, Grace A Usher, Jeffrey W Kelly
Incomplete Refolding of Antibody Light Chains to Non-Native, Protease-Sensitive Conformations Leads to Aggregation: A Mechanism of Amyloidogenesis in Patients? Biochemistry 56 (50) (2017)