Christopher M Dobson (Michele Vendruscolo)

Scopus Author ID ORCID

Publication Activity (10 Years)

Years Active: 2017-2023
Publications (10 Years): 146

Top Venues

ACS chemical neuroscience

Proceedings of the National Academy of Sciences of the United States of America

Nature communications

Science advances

University of Cambridge

This page only lists publications with an associated author ORCID identifier.

Affiliation History

University of Cambridge Oct 1o 2010

United Kingdom

Professor :: Department of Chemistry

Publications

Nadia A Erkamp, Marc Oeller, Tomas Sneideris, Hannes Ausserwoger, Aviad Levin, Timothy J Welsh, Runzhang Qi, Daoyuan Qian, Nikolai Lorenzen, Hongjia Zhu, Pietro Sormanni, Christopher M Dobson, Tuomas P J Knowles
Multidimensional Protein Solubility Optimization with an Ultrahigh-Throughput Microfluidic Platform. Analytical chemistry (2023)
Alyssa Miller, Jiapeng Wei, Sarah Meehan, Christopher M Dobson, Mark E Welland, David Klenerman, Christopher M Dobson, Francesco Simone Ruggeri, Tuomas P J Knowles
Formation of amyloid loops in brain tissues is controlled by the flexibility of protofibril chains. Proceedings of the National Academy of Sciences of the United States of America 120 (21) (2023)
Samuel T Dada, Maarten C Hardenberg, Zenon Toprakcioglu, Lena K Mrugalla, Mariana P Cali, Mollie O McKeon, Ewa Klimont, Thomas C T Michaels, Tuomas P J Knowles, Christopher M Dobson
Spontaneous nucleation and fast aggregate-dependent proliferation of α-synuclein aggregates within liquid condensates at neutral pH. Proceedings of the National Academy of Sciences of the United States of America 120 (9) (2023)
Taniya Bhardwaj, Kundlik Gadhave, Shivani K Kapuganti, Prateek Kumar, Zacharias Faidon Brotzakis, Kumar Udit Saumya, Namyashree Nayak, Ankur Kumar, Richa Joshi, Bodhidipra Mukherjee, Aparna Bhardwaj, Krishan Gopal Thakur, Neha Garg, Christopher M Dobson, Rajanish Giri
Amyloidogenic proteins in the SARS-CoV and SARS-CoV-2 proteomes. Nature communications 14 (1) (2023)
Christopher M Dobson
Thermodynamic and kinetic approaches for drug discovery to target protein misfolding and aggregation. Expert opinion on drug discovery (2023)
Priyanka Joshi, Sean Chia, Xiaoting Yang, Michele Perni, Justus M Gabriel, Marshall Gilmer, Ryan Limbocker, Johnny Habchi, Christopher M Dobson
Combinations of Vitamin A and Vitamin E Metabolites Confer Resilience against Amyloid-β Aggregation. ACS chemical neuroscience 14 (4) (2023)
Alyssa Miller, Jiapeng Wei, Sarah Meehan, Christopher M Dobson, Mark E Welland, David Klenerman, Christopher M Dobson, Francesco Simone Ruggeri, Tuomas P J Knowles
Formation of amyloid loops in brain tissues is controlled by the flexibility of protofibril chains. Proceedings of the National Academy of Sciences of the United States of America 120 (21) (2023)
Priyanka Joshi, Sean Chia, Xiaoting Yang, Michele Perni, Justus M Gabriel, Marshall Gilmer, Ryan Limbocker, Johnny Habchi, Christopher M Dobson
Combinations of Vitamin A and Vitamin E Metabolites Confer Resilience against Amyloid-β Aggregation. ACS chemical neuroscience (2023)
Priyanka Joshi, Sean Chia, Xiaoting Yang, Michele Perni, Justus M Gabriel, Marshall Gilmer, Ryan Limbocker, Johnny Habchi, Christopher M Dobson
Combinations of Vitamin A and Vitamin E Metabolites Confer Resilience against Amyloid-β Aggregation. ACS chemical neuroscience 14 (4) (2023)
Samuel T Dada, Maarten C Hardenberg, Zenon Toprakcioglu, Lena K Mrugalla, Mariana P Cali, Mollie O McKeon, Ewa Klimont, Thomas C T Michaels, Tuomas P J Knowles, Christopher M Dobson
Spontaneous nucleation and fast aggregate-dependent proliferation of α-synuclein aggregates within liquid condensates at neutral pH. Proceedings of the National Academy of Sciences of the United States of America 120 (9) (2023)
Taniya Bhardwaj, Kundlik Gadhave, Shivani K Kapuganti, Prateek Kumar, Zacharias Faidon Brotzakis, Kumar Udit Saumya, Namyashree Nayak, Ankur Kumar, Richa Joshi, Bodhidipra Mukherjee, Aparna Bhardwaj, Krishan Gopal Thakur, Neha Garg, Christopher M Dobson, Rajanish Giri
Amyloidogenic proteins in the SARS-CoV and SARS-CoV-2 proteomes. Nature communications 14 (1) (2023)
Christine M Lim, Alicia González Díaz, Monika Fuxreiter, Frank W Pun, Alex Zhavoronkov, Christopher M Dobson
Multiomic prediction of therapeutic targets for human diseases associated with protein phase separation. Proceedings of the National Academy of Sciences of the United States of America 120 (40) (2023)
Robert I Horne, Michael A Metrick, Wing Man, Dillon J Rinauro, Z Faidon Brotzakis, Sean Chia, Georg Meisl, Christopher M Dobson
Secondary Processes Dominate the Quiescent, Spontaneous Aggregation of α-Synuclein at Physiological pH with Sodium Salts. ACS chemical neuroscience (2023)
Mark R Wilson, Sandeep Satapathy, Christopher M Dobson
Extracellular protein homeostasis in neurodegenerative diseases. Nature reviews. Neurology (2023)
Andras Hatos, João Mc Teixeira, Susana Barrera-Vilarmau, Attila Horvath, Silvio C E Tosatto, Christopher M Dobson, Monika Fuxreiter
FuzPred: a web server for the sequence-based prediction of the context-dependent binding modes of proteins. Nucleic acids research (2023)
Marc Oeller, Ryan Kang, Rosie Bell, Hannes Ausserwöger, Pietro Sormanni, Christopher M Dobson
Sequence-based prediction of pH-dependent protein solubility using CamSol. Briefings in bioinformatics (2023)
Sarah E Sandler, Robert I Horne, Sara Rocchetti, Robert Novak, Nai-Shu Hsu, Marta Castellana Cruz, Z Faidon Brotzakis, Rebecca C Gregory, Sean Chia, Gonçalo J L Bernardes, Ulrich F Keyser, Christopher M Dobson
Multiplexed Digital Characterization of Misfolded Protein Oligomers via Solid-State Nanopores. Journal of the American Chemical Society (2023)
Marc Oeller, Ryan Kang, Rosie Bell, Hannes Ausserwöger, Pietro Sormanni, Christopher M Dobson
Sequence-based prediction of pH-dependent protein solubility using CamSol. Briefings in bioinformatics 24 (2) (2023)
Jonathon Nixon-Abell, Francesco Simone Ruggeri, Seema Qamar, Therese W Herling, Magdalena A Czekalska, Yi Shen, Guozhen Wang, Christopher King, Michael S Fernandopulle, Tomas Šneideris, Joseph L Watson, Visakh V S Pillai, William Meadows, James W Henderson, Joseph E Chambers, Jane L Wagstaff, Sioned H Williams, Helena Coyle, Yuqian Lu, Shuyuan Zhang, Stefan John Marciniak, Stefan M V Freund, Emmanuel Derivery, Michael Emmerson Ward, Christopher M Dobson, Tuomas P J Knowles, Peter St George-Hyslop
ANXA11 biomolecular condensates facilitate protein-lipid phase coupling on lysosomal membranes. bioRxiv : the preprint server for biology (2023)
Marc Oeller, Ryan J D Kang, Hannah L Bolt, Ana L Gomes Dos Santos, Annika Langborg Weinmann, Antonios Nikitidis, Pavol Zlatoidsky, Wu Su, Werngard Czechtizky, Leonardo De Maria, Pietro Sormanni, Christopher M Dobson
Sequence-based prediction of the intrinsic solubility of peptides containing non-natural amino acids. Nature communications 14 (1) (2023)
Alyssa Miller, Sean Chia, Zenon Toprakcioglu, Tuuli A Hakala, Roman Schmid, Yaduo Feng, Tadas Kartanas, Ayaka Kamada, Christopher M Dobson, Francesco Simone Ruggeri, Tuomas P J Knowles
Enhanced surface nanoanalytics of transient biomolecular processes. Science advances 9 (2) (2023)
Ryan Limbocker, Nunilo Cremades, Roberta Cascella, Peter M Tessier, Christopher M Dobson, Fabrizio Chiti
Characterization of Pairs of Toxic and Nontoxic Misfolded Protein Oligomers Elucidates the Structural Determinants of Oligomer Toxicity in Protein Misfolding Diseases. Accounts of chemical research (2023)
Taniya Bhardwaj, Kundlik Gadhave, Shivani K Kapuganti, Prateek Kumar, Zacharias Faidon Brotzakis, Kumar Udit Saumya, Namyashree Nayak, Ankur Kumar, Richa Joshi, Bodhidipra Mukherjee, Aparna Bhardwaj, Krishan Gopal Thakur, Neha Garg, Christopher M Dobson, Rajanish Giri
Amyloidogenic proteins in the SARS-CoV and SARS-CoV-2 proteomes. Nature communications 14 (1) (2023)
Nadia A Erkamp, Marc Oeller, Tomas Sneideris, Hannes Ausserwoger, Aviad Levin, Timothy J Welsh, Runzhang Qi, Daoyuan Qian, Nikolai Lorenzen, Hongjia Zhu, Pietro Sormanni, Christopher M Dobson, Tuomas P J Knowles
Multidimensional Protein Solubility Optimization with an Ultrahigh-Throughput Microfluidic Platform. Analytical chemistry (2023)
Samuel T Dada, Maarten C Hardenberg, Zenon Toprakcioglu, Lena K Mrugalla, Mariana P Cali, Mollie O McKeon, Ewa Klimont, Thomas C T Michaels, Tuomas P J Knowles, Christopher M Dobson
Spontaneous nucleation and fast aggregate-dependent proliferation of α-synuclein aggregates within liquid condensates at neutral pH. Proceedings of the National Academy of Sciences of the United States of America 120 (9) (2023)
Z Faidon Brotzakis, Thomas Löhr, Steven Truong, Samuel Hoff, Massimiliano Bonomi, Christopher M Dobson
Determination of the Structure and Dynamics of the Fuzzy Coat of an Amyloid Fibril of IAPP Using Cryo-Electron Microscopy. Biochemistry (2023)
Priyanka Joshi, Sean Chia, Xiaoting Yang, Michele Perni, Justus M Gabriel, Marshall Gilmer, Ryan Limbocker, Johnny Habchi, Christopher M Dobson
Combinations of Vitamin A and Vitamin E Metabolites Confer Resilience against Amyloid-β Aggregation. ACS chemical neuroscience 14 (4) (2023)
Alyssa Miller, Sean Chia, Zenon Toprakcioglu, Tuuli A Hakala, Roman Schmid, Yaduo Feng, Tadas Kartanas, Ayaka Kamada, Christopher M Dobson, Francesco Simone Ruggeri, Tuomas P J Knowles
Enhanced surface nanoanalytics of transient biomolecular processes. Science advances 9 (2) (2023)
Priyanka Joshi, Sean Chia, Xiaoting Yang, Michele Perni, Justus M Gabriel, Marshall Gilmer, Ryan Limbocker, Johnny Habchi, Christopher M Dobson
Combinations of Vitamin A and Vitamin E Metabolites Confer Resilience against Amyloid-β Aggregation. ACS chemical neuroscience 14 (4) (2023)
Robert I Horne, Mhd Hussein Murtada, Donghui Huo, Z Faidon Brotzakis, Rebecca C Gregory, Andrea Possenti, Sean Chia, Christopher M Dobson
Exploration and Exploitation Approaches Based on Generative Machine Learning to Identify Potent Small Molecule Inhibitors of α-Synuclein Secondary Nucleation. Journal of chemical theory and computation (2023)
Samuel T Dada, Maarten C Hardenberg, Zenon Toprakcioglu, Lena K Mrugalla, Mariana P Cali, Mollie O McKeon, Ewa Klimont, Thomas C T Michaels, Tuomas P J Knowles, Christopher M Dobson
Spontaneous nucleation and fast aggregate-dependent proliferation of α-synuclein aggregates within liquid condensates at neutral pH. Proceedings of the National Academy of Sciences of the United States of America 120 (9) (2023)
Priyanka Joshi, Sean Chia, Xiaoting Yang, Michele Perni, Justus M Gabriel, Marshall Gilmer, Ryan Limbocker, Johnny Habchi, Christopher M Dobson
Combinations of Vitamin A and Vitamin E Metabolites Confer Resilience against Amyloid-β Aggregation. ACS chemical neuroscience 14 (4) (2023)
Alyssa Miller, Jiapeng Wei, Sarah Meehan, Christopher M Dobson, Mark E Welland, David Klenerman, Christopher M Dobson, Francesco Simone Ruggeri, Tuomas P J Knowles
Formation of amyloid loops in brain tissues is controlled by the flexibility of protofibril chains. Proceedings of the National Academy of Sciences of the United States of America 120 (21) (2023)
Silvia Errico, Giacomo Lucchesi, Davide Odino, Enass Youssef Osman, Roberta Cascella, Lorenzo Neri, Claudia Capitini, Martino Calamai, Francesco Bemporad, Cristina Cecchi, William A Kinney, Denise Barbut, Annalisa Relini, Claudio Canale, Gabriella Caminati, Ryan Limbocker, Christopher M Dobson, Michael Zasloff, Fabrizio Chiti
Quantitative Attribution of the Protective Effects of Aminosterols against Protein Aggregates to Their Chemical Structures and Ability to Modulate Biological Membranes. Journal of medicinal chemistry (2023)
Priyanka Joshi, Sean Chia, Xiaoting Yang, Michele Perni, Justus M Gabriel, Marshall Gilmer, Ryan Limbocker, Johnny Habchi, Christopher M Dobson
Combinations of Vitamin A and Vitamin E Metabolites Confer Resilience against Amyloid-β Aggregation. ACS chemical neuroscience 14 (4) (2023)
Marc Oeller, Ryan Kang, Rosie Bell, Hannes Ausserwöger, Pietro Sormanni, Christopher M Dobson
Sequence-based prediction of pH-dependent protein solubility using CamSol. Briefings in bioinformatics 24 (2) (2023)
Alyssa Miller, Sean Chia, Zenon Toprakcioglu, Tuuli A Hakala, Roman Schmid, Yaduo Feng, Tadas Kartanas, Ayaka Kamada, Christopher M Dobson, Francesco Simone Ruggeri, Tuomas P J Knowles
Enhanced surface nanoanalytics of transient biomolecular processes. Science advances 9 (2) (2023)
Taniya Bhardwaj, Kundlik Gadhave, Shivani K Kapuganti, Prateek Kumar, Zacharias Faidon Brotzakis, Kumar Udit Saumya, Namyashree Nayak, Ankur Kumar, Richa Joshi, Bodhidipra Mukherjee, Aparna Bhardwaj, Krishan Gopal Thakur, Neha Garg, Christopher M Dobson, Rajanish Giri
Amyloidogenic proteins in the SARS-CoV and SARS-CoV-2 proteomes. Nature communications 14 (1) (2023)
Andras Hatos, Silvio C E Tosatto, Christopher M Dobson, Monika Fuxreiter
FuzDrop on AlphaFold: visualizing the sequence-dependent propensity of liquid-liquid phase separation and aggregation of proteins. Nucleic acids research (2022)
Attila Horvath, Christopher M Dobson, Monika Fuxreiter
Sequence-based Prediction of the Cellular Toxicity Associated with Amyloid Aggregation within Protein Condensates. Biochemistry 61 (22) (2022)
Thomas Löhr, Pietro Sormanni, Christopher M Dobson
Conformational Entropy as a Potential Liability of Computationally Designed Antibodies. Biomolecules 12 (5) (2022)
Derya Emin, Yu P Zhang, Evgeniia Lobanova, Alyssa Miller, Xuecong Li, Zengjie Xia, Helen Dakin, Dimitrios I Sideris, Jeff Y L Lam, Rohan T Ranasinghe, Antonina Kouli, Yanyan Zhao, Suman De, Tuomas P J Knowles, Christopher M Dobson, Francesco Simone Ruggeri, Franklin I Aigbirhio, Caroline H Williams-Gray, David Klenerman
Small soluble α-synuclein aggregates are the toxic species in Parkinson's disease. Nature communications 13 (1) (2022)
Klara Kulenkampff, Derya Emin, Roxine Staats, Yu P Zhang, Laila Sakhnini, Antonina Kouli, Oded Rimon, Evgeniia Lobanova, Caroline H Williams-Gray, Francesco A Aprile, Pietro Sormanni, David Klenerman, Christopher M Dobson
An antibody scanning method for the detection of α-synuclein oligomers in the serum of Parkinson's disease patients. Chemical science 13 (46) (2022)
Thomas Löhr, Kai Kohlhoff, Gabriella T Heller, Carlo Camilloni, Christopher M Dobson
A Small Molecule Stabilizes the Disordered Native State of the Alzheimer's Aβ Peptide. ACS chemical neuroscience 13 (12) (2022)
Zenon Toprakcioglu, Ayaka Kamada, Thomas C T Michaels, Mengqi Xie, Johannes Krausser, Jiapeng Wei, And Ela Šarić, Christopher M Dobson, Tuomas P J Knowles
Adsorption free energy predicts amyloid protein nucleation rates. Proceedings of the National Academy of Sciences of the United States of America 119 (31) (2022)
Annika Deckert, Anaïs M E Cassaignau, Xiaolin Wang, Tomasz Włodarski, Sammy H S Chan, Christopher A Waudby, John P Kirkpatrick, Christopher M Dobson, Lisa D Cabrita, John Christodoulou
Common sequence motifs of nascent chains engage the ribosome surface and trigger factor. Proceedings of the National Academy of Sciences of the United States of America 118 (52) (2022)
Attila Horvath, Monika Fuxreiter, Christopher M Dobson, Carl Holt, John A Carver
Are casein micelles extracellular condensates formed by liquid-liquid phase separation? FEBS letters 596 (16) (2022)
Sean Chia, Z Faidon Brotzakis, Robert I Horne, Andrea Possenti, Benedetta Mannini, Rodrigo Cataldi, Magdalena Nowinska, Roxine Staats, Sara Linse, Tuomas P J Knowles, Johnny Habchi, Christopher M Dobson
Structure-Based Discovery of Small-Molecule Inhibitors of the Autocatalytic Proliferation of α-Synuclein Aggregates. Molecular pharmaceutics (2022)
Maarten C Hardenberg, Tessa Sinnige, Sam Casford, Samuel T Dada, Chetan Poudel, Elizabeth A Robinson, Monika Fuxreiter, Clemens F Kaminksi, Gabriele S Kaminski Schierle, Ellen A A Nollen, Christopher M Dobson, Christopher M Dobson
Observation of an α-synuclein liquid droplet state and its maturation into Lewy body-like assemblies. Journal of molecular cell biology 13 (4) (2022)
Halina Mikolajek, Miriam Weckener, Z Faidon Brotzakis, Jiandong Huo, Evmorfia V Dalietou, Audrey Le Bas, Pietro Sormanni, Peter J Harrison, Philip N Ward, Steven Truong, Lucile Moynié, Daniel K Clare, Maud Dumoux, Joshua Dormon, Chelsea Norman, Naveed Hussain, Vinod K Vogirala, Raymond J Owens, Christopher M Dobson, James H Naismith
Correlation between the binding affinity and the conformational entropy of nanobody SARS-CoV-2 spike protein complexes. Proceedings of the National Academy of Sciences of the United States of America 119 (31) (2022)
Kevin N Baumann, Greta Šneiderienė, Michele Sanguanini, Matthias M Schneider, Oded Rimon, Alicia González Díaz, Heather Greer, Dev Thacker, Sara Linse, Tuomas P J Knowles, Christopher M Dobson
A Kinetic Map of the Influence of Biomimetic Lipid Model Membranes on Aβ 42 Aggregation. ACS chemical neuroscience 14 (2) (2022)
Kevin N Baumann, Greta Šneiderienė, Michele Sanguanini, Matthias M Schneider, Oded Rimon, Alicia González Díaz, Heather Greer, Dev Thacker, Sara Linse, Tuomas P J Knowles, Christopher M Dobson
A Kinetic Map of the Influence of Biomimetic Lipid Model Membranes on Aβ 42 Aggregation. ACS chemical neuroscience 14 (2) (2022)
Kevin N Baumann, Greta Šneiderienė, Michele Sanguanini, Matthias M Schneider, Oded Rimon, Alicia González Díaz, Heather Greer, Dev Thacker, Sara Linse, Tuomas P J Knowles, Christopher M Dobson
A Kinetic Map of the Influence of Biomimetic Lipid Model Membranes on Aβ 42 Aggregation. ACS chemical neuroscience 14 (2) (2022)
Rosie Bell, Rebecca J Thrush, Marta Castellana-Cruz, Marc Oeller, Roxine Staats, Aishwarya Nene, Patrick Flagmeier, Catherine K Xu, Sandeep Satapathy, Céline Galvagnion, Mark R Wilson, Christopher M Dobson, Janet R Kumita, Christopher M Dobson
N-Terminal Acetylation of α-Synuclein Slows down Its Aggregation Process and Alters the Morphology of the Resulting Aggregates. Biochemistry 61 (17) (2022)
Cristina Olivieri, Geoffrey C Li, Yingjie Wang, Manu V S, Caitlin Walker, Jonggul Kim, Carlo Camilloni, Alfonso De Simone, Christopher M Dobson, David A Bernlohr, Susan S Taylor, Gianluigi Veglia
ATP-competitive inhibitors modulate the substrate binding cooperativity of a kinase by altering its conformational entropy. Science advances 8 (30) (2022)
Mauricio Aguilar Rangel, Alice Bedwell, Elisa Costanzi, Ross J Taylor, Rosaria Russo, Gonçalo J L Bernardes, Stefano Ricagno, Judith Frydman, Christopher M Dobson, Pietro Sormanni
Fragment-based computational design of antibodies targeting structured epitopes. Science advances 8 (45) (2022)
Ryan P Kreiser, Aidan K Wright, Liam R Sasser, Dillon J Rinauro, Justus M Gabriel, Claire M Hsu, Jorge A Hurtado, Tristan L McKenzie, Silvia Errico, J Alex Albright, Lance Richardson, Victor A Jaffett, Dawn E Riegner, Lam T Nguyen, Kathleen LeForte, Michael Zasloff, Jared E Hollows, Fabrizio Chiti, Christopher M Dobson, Ryan Limbocker
A Brain-Permeable Aminosterol Regulates Cell Membranes to Mitigate the Toxicity of Diverse Pore-Forming Agents. ACS chemical neuroscience 13 (8) (2022)
Christopher M Dobson, Monika Fuxreiter
Protein condensation diseases: therapeutic opportunities. Nature communications 13 (1) (2022)
Kevin N Baumann, Greta Šneiderienė, Michele Sanguanini, Matthias M Schneider, Oded Rimon, Alicia González Díaz, Heather Greer, Dev Thacker, Sara Linse, Tuomas P J Knowles, Christopher M Dobson
A Kinetic Map of the Influence of Biomimetic Lipid Model Membranes on Aβ 42 Aggregation. ACS chemical neuroscience 14 (2) (2022)
Kevin N Baumann, Greta Šneiderienė, Michele Sanguanini, Matthias M Schneider, Oded Rimon, Alicia González Díaz, Heather Greer, Dev Thacker, Sara Linse, Tuomas P J Knowles, Christopher M Dobson
A Kinetic Map of the Influence of Biomimetic Lipid Model Membranes on Aβ 42 Aggregation. ACS chemical neuroscience 14 (2) (2022)
Ross J Taylor, Mauricio Aguilar Rangel, Michael B Geeson, Pietro Sormanni, Christopher M Dobson, Gonçalo J L Bernardes
π-Clamp-Mediated Homo- and Heterodimerization of Single-Domain Antibodies via Site-Specific Homobifunctional Conjugation. Journal of the American Chemical Society 144 (29) (2022)
Klara Kulenkampff, Derya Emin, Roxine Staats, Yu P Zhang, Laila Sakhnini, Antonina Kouli, Oded Rimon, Evgeniia Lobanova, Caroline H Williams-Gray, Francesco A Aprile, Pietro Sormanni, David Klenerman, Christopher M Dobson
An antibody scanning method for the detection of α-synuclein oligomers in the serum of Parkinson's disease patients. Chemical science 13 (46) (2022)
Klara Kulenkampff, Derya Emin, Roxine Staats, Yu P Zhang, Laila Sakhnini, Antonina Kouli, Oded Rimon, Evgeniia Lobanova, Caroline H Williams-Gray, Francesco A Aprile, Pietro Sormanni, David Klenerman, Christopher M Dobson
An antibody scanning method for the detection of α-synuclein oligomers in the serum of Parkinson's disease patients. Chemical science 13 (46) (2022)
Kevin N Baumann, Greta Šneiderienė, Michele Sanguanini, Matthias M Schneider, Oded Rimon, Alicia González Díaz, Heather Greer, Dev Thacker, Sara Linse, Tuomas P J Knowles, Christopher M Dobson
A Kinetic Map of the Influence of Biomimetic Lipid Model Membranes on Aβ 42 Aggregation. ACS chemical neuroscience (2022)
Klara Kulenkampff, Adriana-M Wolf Perez, Pietro Sormanni, Johnny Habchi, Christopher M Dobson
Quantifying misfolded protein oligomers as drug targets and biomarkers in Alzheimer and Parkinson diseases. Nature reviews. Chemistry 5 (4) (2021)
Priyanka Joshi, Michele Perni, Ryan Limbocker, Benedetta Mannini, Sam Casford, Sean Chia, Johnny Habchi, Johnathan Labbadia, Christopher M Dobson, Christopher M Dobson
Publisher Correction: Two human metabolites rescue a C. elegans model of Alzheimer's disease via a cytosolic unfolded protein response. Communications biology 4 (1) (2021)
Priyanka Joshi, Michele Perni, Ryan Limbocker, Benedetta Mannini, Sam Casford, Sean Chia, Johnny Habchi, Johnathan Labbadia, Christopher M Dobson, Christopher M Dobson
Two human metabolites rescue a C. elegans model of Alzheimer's disease via a cytosolic unfolded protein response. Communications biology 4 (1) (2021)
Dimitrios I Sideris, John S H Danial, Derya Emin, Francesco S Ruggeri, Zengjie Xia, Yu P Zhang, Evgeniia Lobanova, Helen Dakin, Suman De, Alyssa Miller, Jason C Sang, Tuomas P J Knowles, Christopher M Dobson, Graham Fraser, Damian Crowther, David Klenerman
Soluble amyloid beta-containing aggregates are present throughout the brain at early stages of Alzheimer's disease. Brain communications 3 (3) (2021)
Massimiliano Runfola, Michele Perni, Xiaoting Yang, Maria Marchese, Andrea Bacci, Serena Mero, Filippo M Santorelli, Beatrice Polini, Grazia Chiellini, Daniela Giuliani, Antonietta Vilella, Martina Bodria, Eleonora Daini, Eleonora Vandini, Simon Rudge, Sheraz Gul, Michale O J Wakelam, Christopher M Dobson, Simona Rapposelli
Identification of a Thyroid Hormone Derivative as a Pleiotropic Agent for the Treatment of Alzheimer's Disease. Pharmaceuticals (Basel, Switzerland) 14 (12) (2021)
Erika Kelmer Sacramento, Joanna M Kirkpatrick, Mariateresa Mazzetto, Mario Baumgart, Aleksandar Bartolome, Simone Di Sanzo, Cinzia Caterino, Michele Sanguanini, Nikoletta Papaevgeniou, Maria Lefaki, Dorothee Childs, Sara Bagnoli, Eva Terzibasi Tozzini, Domenico Di Fraia, Natalie Romanov, Peter H Sudmant, Wolfgang Huber, Niki Chondrogianni, Christopher M Dobson, Alessandro Cellerino, Alessandro Ori
Reduced proteasome activity in the aging brain results in ribosome stoichiometry loss and aggregation. Molecular systems biology 16 (6) (2021)
Z Faidon Brotzakis, Philip R Lindstedt, Ross J Taylor, Dillon J Rinauro, Nicholas C T Gallagher, Gonçalo J L Bernardes, Christopher M Dobson
A Structural Ensemble of a Tau-Microtubule Complex Reveals Regulatory Tau Phosphorylation and Acetylation Mechanisms. ACS central science 7 (12) (2021)
Rodrigo Cataldi, Sean Chia, Katarina Pisani, Francesco Simone Ruggeri, Catherine K Xu, Tomas Šneideris, Michele Perni, Sunehera Sarwat, Priyanka Joshi, Janet R Kumita, Sara Linse, Johnny Habchi, Tuomas P J Knowles, Benedetta Mannini, Christopher M Dobson, Christopher M Dobson
Publisher Correction: A dopamine metabolite stabilizes neurotoxic amyloid-β oligomers. Communications biology 4 (1) (2021)
Jennifer West, Sandeep Satapathy, Carolyn M Sue, Megan A Kelly, Nicholas J Geraghty, Emma-Jayne Proctor, Pietro Sormanni, Christopher M Dobson, Joel N Buxbaum, Marie Ranson, Mark R Wilson
Neuroserpin and transthyretin are extracellular chaperones that preferentially inhibit amyloid formation. Science advances 7 (50) (2021)
Z Faidon Brotzakis, Thomas Löhr, Christopher M Dobson
Determination of intermediate state structures in the opening pathway of SARS-CoV-2 spike using cryo-electron microscopy. Chemical science 12 (26) (2021)
Rodrigo Cataldi, Sean Chia, Katarina Pisani, Francesco Simone Ruggeri, Catherine K Xu, Tomas Šneideris, Michele Perni, Sunehera Sarwat, Priyanka Joshi, Janet R Kumita, Sara Linse, Johnny Habchi, Tuomas P J Knowles, Benedetta Mannini, Christopher M Dobson, Christopher M Dobson
A dopamine metabolite stabilizes neurotoxic amyloid-β oligomers. Communications biology 4 (1) (2021)
Monika Fuxreiter, Christopher M Dobson
Generic nature of the condensed states of proteins. Nature cell biology 23 (6) (2021)
Matthias M Schneider, Saurabh Gautam, Therese W Herling, Ewa Andrzejewska, Georg Krainer, Alyssa M Miller, Victoria A Trinkaus, Quentin A E Peter, Francesco Simone Ruggeri, Christopher M Dobson, Andreas Bracher, Christopher M Dobson, F Ulrich Hartl, Tuomas P J Knowles
The Hsc70 disaggregation machinery removes monomer units directly from α-synuclein fibril ends. Nature communications 12 (1) (2021)
Wing K Man, Bogachan Tahirbegi, Michail D Vrettas, Swapan Preet, Liming Ying, Christopher M Dobson, Alfonso De Simone, Giuliana Fusco
The docking of synaptic vesicles on the presynaptic membrane induced by α-synuclein is modulated by lipid composition. Nature communications 12 (1) (2021)
Giulia Fani, Benedetta Mannini, Giulia Vecchi, Roberta Cascella, Cristina Cecchi, Christopher M Dobson, Christopher M Dobson, Fabrizio Chiti
Aβ Oligomers Dysregulate Calcium Homeostasis by Mechanosensitive Activation of AMPA and NMDA Receptors. ACS chemical neuroscience 12 (4) (2021)
Urszula Nowicka, Piotr Chroscicki, Karen Stroobants, Maria Sladowska, Michal Turek, Barbara Uszczynska-Ratajczak, Rishika Kundra, Tomasz Goral, Michele Perni, Christopher M Dobson, Christopher M Dobson, Agnieszka Chacinska
Cytosolic aggregation of mitochondrial proteins disrupts cellular homeostasis by stimulating the aggregation of other proteins. eLife 10 (2021)
Ryan Limbocker, Silvia Errico, Denise Barbut, Tuomas P J Knowles, Christopher M Dobson, Fabrizio Chiti, Michael Zasloff
Squalamine and trodusquemine: two natural products for neurodegenerative diseases, from physical chemistry to the clinic. Natural product reports (2021)
Tom Scheidt, Jacqueline A Carozza, Carl C Kolbe, Francesco Antonio Aprile, Olga Tkachenko, Mathias M J Bellaiche, Georg Meisl, Quentin A E Peter, Therese W Herling, Samuel Ness, Marta Castellana-Cruz, Justin L P Benesch, Christopher M Dobson, Christopher M Dobson, Paolo Arosio, Tuomas P J Knowles
The binding of the small heat-shock protein αB-crystallin to fibrils of α-synuclein is driven by entropic forces. Proceedings of the National Academy of Sciences of the United States of America 118 (38) (2021)
Tessa Sinnige, Georg Meisl, Thomas C T Michaels, Christopher M Dobson, Tuomas P J Knowles, Richard I Morimoto
Kinetic analysis reveals that independent nucleation events determine the progression of polyglutamine aggregation in C. elegans. Proceedings of the National Academy of Sciences of the United States of America 118 (11) (2021)
Jiacheng Lin, Chiara Figazzolo, Michael A Metrick, Pietro Sormanni, Christopher M Dobson
Computational maturation of a single-domain antibody against Aβ42 aggregation. Chemical science 12 (41) (2021)
Philip R Lindstedt, Ross J Taylor, Gonçalo J L Bernardes, Christopher M Dobson
Facile Installation of Post-translational Modifications on the Tau Protein via Chemical Mutagenesis. ACS chemical neuroscience 12 (3) (2021)
Florian Buhr, Prashanth S Ciryam, Christopher M Dobson
A mistranslation-prone transcriptome underlying polyglutamine expansion diseases. Nature reviews. Molecular cell biology 22 (9) (2021)
Zacharias Faidon Brotzakis, Christopher M Dobson, Peter G Bolhuis
A method of incorporating rate constants as kinetic constraints in molecular dynamics simulations. Proceedings of the National Academy of Sciences of the United States of America 118 (2) (2021)
Anita Pras, Bert Houben, Francesco Antonio Aprile, Renée Seinstra, Rodrigo Gallardo, Leen Janssen, Wytse Hogewerf, Christian Gallrein, Matthias De Vleeschouwer, Alejandro Mata-Cabana, Mandy Koopman, Esther Stroo, Minke de Vries, Samantha Louise Edwards, Janine Kirstein, Christopher M Dobson, Salvatore Fabio Falsone, Frederic Rousseau, Joost Schymkowitz, Ellen A A Nollen
The cellular modifier MOAG-4/SERF drives amyloid formation through charge complementation. The EMBO journal 40 (21) (2021)
Silvia Errico, Hassan Ramshini, Claudia Capitini, Claudio Canale, Martina Spaziano, Denise Barbut, Martino Calamai, Michael Zasloff, Reinier Oropesa-Nuñez, Christopher M Dobson, Fabrizio Chiti
Quantitative Measurement of the Affinity of Toxic and Nontoxic Misfolded Protein Oligomers for Lipid Bilayers and of its Modulation by Lipid Composition and Trodusquemine. ACS chemical neuroscience 12 (17) (2021)
Diana C Rodriguez Camargo, Eimantas Sileikis, Sean Chia, Emil Axell, Katja Bernfur, Rodrigo L Cataldi, Samuel I A Cohen, Georg Meisl, Johnny Habchi, Tuomas P J Knowles, Christopher M Dobson, Sara Linse
Proliferation of Tau 304-380 Fragment Aggregates through Autocatalytic Secondary Nucleation. ACS chemical neuroscience 12 (23) (2021)
Harald Hampel, John Hardy, Kaj Blennow, Christopher Li Hsian Chen, Giorgio Bianciardi, Seung Hyun Kim, Victor L Villemagne, Paul Aisen, Christopher M Dobson, Takeshi Iwatsubo, Colin L Masters, Min Cho, Lars Lannfelt, Jeffrey L Cummings, Andrea Vergallo
The Amyloid-β Pathway in Alzheimer's Disease. Molecular psychiatry (2021)
Francesco Simone Ruggeri, Johnny Habchi, Sean Chia, Robert I Horne, Christopher M Dobson, Tuomas P J Knowles
Infrared nanospectroscopy reveals the molecular interaction fingerprint of an aggregation inhibitor with single Aβ42 oligomers. Nature communications 12 (1) (2021)
Klara Kulenkampff, Adriana-M Wolf Perez, Pietro Sormanni, Johnny Habchi, Christopher M Dobson
Quantifying misfolded protein oligomers as drug targets and biomarkers in Alzheimer and Parkinson diseases. Nature reviews. Chemistry 5 (4) (2021)
Ryan Limbocker, Benedetta Mannini, Rodrigo Cataldi, Shianne Chhangur, Aidan K Wright, Ryan P Kreiser, J Alex Albright, Sean Chia, Johnny Habchi, Pietro Sormanni, Janet R Kumita, Francesco Simone Ruggeri, Christopher M Dobson, Fabrizio Chiti, Francesco Antonio Aprile, Christopher M Dobson
Rationally Designed Antibodies as Research Tools to Study the Structure-Toxicity Relationship of Amyloid-β Oligomers. International journal of molecular sciences 21 (12) (2020)
Attila Horvath, Marton Miskei, Viktor Ambrus, Christopher M Dobson, Monika Fuxreiter
Sequence-based prediction of protein binding mode landscapes. PLoS computational biology 16 (5) (2020)
Mandy Koopman, Quentin A E Peter, Renée I Seinstra, Michele Perni, Christopher M Dobson, Christopher M Dobson, Tuomas P J Knowles, Ellen A A Nollen
Assessing motor-related phenotypes of Caenorhabditis elegans with the wide field-of-view nematode tracking platform. Nature protocols 15 (6) (2020)
Tessa Sinnige, Karen Stroobants, Christopher M Dobson, Christopher M Dobson
Biophysical studies of protein misfolding and aggregation in in vivo models of Alzheimer's and Parkinson's diseases. Quarterly reviews of biophysics 49 (2020)
Gabriella T Heller, Francesco Antonio Aprile, Thomas C T Michaels, Ryan Limbocker, Michele Perni, Francesco Simone Ruggeri, Benedetta Mannini, Thomas Löhr, Massimiliano Bonomi, Carlo Camilloni, Alfonso De Simone, Isabella C Felli, Roberta Pierattelli, Tuomas P J Knowles, Christopher M Dobson, Christopher M Dobson
Small-molecule sequestration of amyloid-β as a drug discovery strategy for Alzheimer's disease. Science advances 6 (45) (2020)
Patrick Flagmeier, Suman De, Thomas C T Michaels, Xiaoting Yang, Alexander J Dear, Cecilia Emanuelsson, Christopher M Dobson, Sara Linse, David Klenerman, Tuomas P J Knowles, Christopher M Dobson
Direct measurement of lipid membrane disruption connects kinetics and toxicity of Aβ42 aggregation. Nature structural & molecular biology 27 (10) (2020)
Thomas C T Michaels, And Ela Šarić, Samo Curk, Katja Bernfur, Paolo Arosio, Georg Meisl, Alexander J Dear, Samuel I A Cohen, Christopher M Dobson, Christopher M Dobson, Sara Linse, Tuomas P J Knowles
Dynamics of oligomer populations formed during the aggregation of Alzheimer's Aβ42 peptide. Nature chemistry 12 (5) (2020)

Christopher M Dobson.css-eqlu8i{font-size:small;padding-left:4px;} (Michele Vendruscolo)

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Christopher M Dobson (Michele Vendruscolo)