Christopher M Dobson (Michele Vendruscolo)

Scopus Author ID ORCID

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 203

Top Venues

ACS chemical neuroscience

Proceedings of the National Academy of Sciences of the United States of America

Nature communications

Science advances

University of Cambridge

This page only lists publications with an associated author ORCID identifier.

Affiliation History

University of Cambridge Oct 01 2010

United Kingdom

Professor :: Department of Chemistry

Publications

Sean Chia, Rodrigo Lessa Cataldi, Francesco Simone Ruggeri, Ryan Limbocker, Itzel Condado-Morales, Katarina Pisani, Andrea Possenti, Sara Linse, Tuomas P J Knowles, Johnny Habchi, Benedetta Mannini, Christopher M Dobson
A Relationship between the Structures and Neurotoxic Effects of Aβ Oligomers Stabilized by Different Metal Ions. ACS chemical neuroscience 15 (6) (2024)
Robert I Horne, Ewa A Andrzejewska, Parvez Alam, Z Faidon Brotzakis, Ankit Srivastava, Alice Aubert, Magdalena Nowinska, Rebecca C Gregory, Roxine Staats, Andrea Possenti, Sean Chia, Pietro Sormanni, Bernardino Ghetti, Byron Caughey, Tuomas P J Knowles, Christopher M Dobson
Discovery of potent inhibitors of α-synuclein aggregation using structure-based iterative learning. Nature chemical biology 20 (5) (2024)
Robert I Horne, Jared Wilson-Godber, Alicia González Díaz, Z Faidon Brotzakis, Srijit Seal, Rebecca C Gregory, Andrea Possenti, Sean Chia, Christopher M Dobson
Using Generative Modeling to Endow with Potency Initially Inert Compounds with Good Bioavailability and Low Toxicity. Journal of chemical information and modeling 64 (3) (2024)
Sean Chia, Rodrigo Lessa Cataldi, Francesco Simone Ruggeri, Ryan Limbocker, Itzel Condado-Morales, Katarina Pisani, Andrea Possenti, Sara Linse, Tuomas P J Knowles, Johnny Habchi, Benedetta Mannini, Christopher M Dobson
A Relationship between the Structures and Neurotoxic Effects of Aβ Oligomers Stabilized by Different Metal Ions. ACS chemical neuroscience 15 (6) (2024)
Alexander Röntgen, Zenon Toprakcioglu, James E Tomkins, Christopher M Dobson
Modulation of α-synuclein in vitro aggregation kinetics by its alternative splice isoforms. Proceedings of the National Academy of Sciences of the United States of America 121 (7) (2024)
Alicia González Díaz, Rodrigo Cataldi, Benedetta Mannini, Christopher M Dobson
Preparation and Characterization of Zn(II)-Stabilized Aβ 42 Oligomers. ACS chemical neuroscience 15 (14) (2024)
Shengyu Zhang, Christine M Lim, Martina Occhetta, Christopher M Dobson
AlphaFold2-based prediction of the co-condensation propensity of proteins. Proceedings of the National Academy of Sciences of the United States of America 121 (34) (2024)
Shengyu Zhang, Christine M Lim, Martina Occhetta, Christopher M Dobson
AlphaFold2-based prediction of the co-condensation propensity of proteins. Proceedings of the National Academy of Sciences of the United States of America 121 (34) (2024)
Alexander Röntgen, Zenon Toprakcioglu, James E Tomkins, Christopher M Dobson
Modulation of α-synuclein in vitro aggregation kinetics by its alternative splice isoforms. Proceedings of the National Academy of Sciences of the United States of America 121 (7) (2024)
Robert I Horne, Ewa A Andrzejewska, Parvez Alam, Z Faidon Brotzakis, Ankit Srivastava, Alice Aubert, Magdalena Nowinska, Rebecca C Gregory, Roxine Staats, Andrea Possenti, Sean Chia, Pietro Sormanni, Bernardino Ghetti, Byron Caughey, Tuomas P J Knowles, Christopher M Dobson
Discovery of potent inhibitors of α-synuclein aggregation using structure-based iterative learning. Nature chemical biology 20 (5) (2024)
Catherine K Xu, Georg Meisl, Ewa A Andrzejewska, Georg Krainer, Alexander J Dear, Marta Castellana-Cruz, Soma Turi, Irina A Edu, Giorgio Vivacqua, Raphaël P B Jacquat, William E Arter, Maria Grazia Spillantini, Christopher M Dobson, Sara Linse, Tuomas P J Knowles
α-Synuclein oligomers form by secondary nucleation. Nature communications 15 (1) (2024)
Udit Surya Saha, Christopher M Dobson, Anne E Carpenter, Shantanu Singh, Andreas Bender, Srijit Seal
Step Forward Cross Validation for Bioactivity Prediction: Out of Distribution Validation in Drug Discovery. bioRxiv : the preprint server for biology (2024)
Cristina Olivieri, Yingjie Wang, Caitlin Walker, Manu Veliparambil Subrahmanian, Kim N Ha, David Bernlohr, Jiali Gao, Carlo Camilloni, Christopher M Dobson, Susan S Taylor, Gianluigi Veglia
The αC-β4 loop controls the allosteric cooperativity between nucleotide and substrate in the catalytic subunit of protein kinase A. eLife 12 (2024)
Catherine K Xu, Georg Meisl, Ewa A Andrzejewska, Georg Krainer, Alexander J Dear, Marta Castellana-Cruz, Soma Turi, Irina A Edu, Giorgio Vivacqua, Raphaël P B Jacquat, William E Arter, Maria Grazia Spillantini, Christopher M Dobson, Sara Linse, Tuomas P J Knowles
α-Synuclein oligomers form by secondary nucleation. Nature communications 15 (1) (2024)
Alyssa Miller, Sean Chia, Ewa Klimont, Tuomas P J Knowles, Christopher M Dobson, Francesco Simone Ruggeri
Maturation-dependent changes in the size, structure and seeding capacity of Aβ42 amyloid fibrils. Communications biology 7 (1) (2024)
Cristina Olivieri, Yingjie Wang, Caitlin Walker, Manu Veliparambil Subrahmanian, Kim N Ha, David Bernlohr, Jiali Gao, Carlo Camilloni, Christopher M Dobson, Susan S Taylor, Gianluigi Veglia
The αC-β4 loop controls the allosteric cooperativity between nucleotide and substrate in the catalytic subunit of protein kinase A. eLife 12 (2024)
Cristina Olivieri, Yingjie Wang, Caitlin Walker, Manu Veliparambil Subrahmanian, Kim N Ha, David Bernlohr, Jiali Gao, Carlo Camilloni, Christopher M Dobson, Susan S Taylor, Gianluigi Veglia
The αC-β4 loop controls the allosteric cooperativity between nucleotide and substrate in the catalytic subunit of protein kinase A. eLife 12 (2024)
Samuel T Dada, Zenon Toprakcioglu, Mariana P Cali, Alexander Röntgen, Maarten C Hardenberg, Owen M Morris, Lena K Mrugalla, Tuomas P J Knowles, Christopher M Dobson
Pharmacological inhibition of α-synuclein aggregation within liquid condensates. Nature communications 15 (1) (2024)
Robert I Horne, Ewa A Andrzejewska, Parvez Alam, Z Faidon Brotzakis, Ankit Srivastava, Alice Aubert, Magdalena Nowinska, Rebecca C Gregory, Roxine Staats, Andrea Possenti, Sean Chia, Pietro Sormanni, Bernardino Ghetti, Byron Caughey, Tuomas P J Knowles, Christopher M Dobson
Discovery of potent inhibitors of α-synuclein aggregation using structure-based iterative learning. Nature chemical biology 20 (5) (2024)
Robert I Horne, Jared Wilson-Godber, Alicia González Díaz, Z Faidon Brotzakis, Srijit Seal, Rebecca C Gregory, Andrea Possenti, Sean Chia, Christopher M Dobson
Using Generative Modeling to Endow with Potency Initially Inert Compounds with Good Bioavailability and Low Toxicity. Journal of chemical information and modeling 64 (3) (2024)
Samuel T Dada, Zenon Toprakcioglu, Mariana P Cali, Alexander Röntgen, Maarten C Hardenberg, Owen M Morris, Lena K Mrugalla, Tuomas P J Knowles, Christopher M Dobson
Pharmacological inhibition of α-synuclein aggregation within liquid condensates. Nature communications 15 (1) (2024)
Alicia González Díaz, Rodrigo Cataldi, Benedetta Mannini, Christopher M Dobson
Preparation and Characterization of Zn(II)-Stabilized Aβ 42 Oligomers. ACS chemical neuroscience 15 (14) (2024)
Sean Chia, Rodrigo Lessa Cataldi, Francesco Simone Ruggeri, Ryan Limbocker, Itzel Condado-Morales, Katarina Pisani, Andrea Possenti, Sara Linse, Tuomas P J Knowles, Johnny Habchi, Benedetta Mannini, Christopher M Dobson
A Relationship between the Structures and Neurotoxic Effects of Aβ Oligomers Stabilized by Different Metal Ions. ACS chemical neuroscience 15 (6) (2024)
Bin Fu, Emma E Brock, Rebecca Andrews, Jonathan C Breiter, Ru Tian, Christina E Toomey, Joanne Lachica, Tammaryn Lashley, Mina Ryten, Nicholas W Wood, Christopher M Dobson, Sonia Gandhi, Lucien E Weiss, Joseph S Beckwith, Steven F Lee
RASP: Optimal Single Puncta Detection in Complex Cellular Backgrounds. The journal of physical chemistry. B 128 (15) (2024)
Shengyu Zhang, Christine M Lim, Martina Occhetta, Christopher M Dobson
AlphaFold2-based prediction of the co-condensation propensity of proteins. Proceedings of the National Academy of Sciences of the United States of America 121 (34) (2024)
Sean Chia, Rodrigo Lessa Cataldi, Francesco Simone Ruggeri, Ryan Limbocker, Itzel Condado-Morales, Katarina Pisani, Andrea Possenti, Sara Linse, Tuomas P J Knowles, Johnny Habchi, Benedetta Mannini, Christopher M Dobson
A Relationship between the Structures and Neurotoxic Effects of Aβ Oligomers Stabilized by Different Metal Ions. ACS chemical neuroscience 15 (6) (2024)
Robert I Horne, Jared Wilson-Godber, Alicia González Díaz, Z Faidon Brotzakis, Srijit Seal, Rebecca C Gregory, Andrea Possenti, Sean Chia, Christopher M Dobson
Using Generative Modeling to Endow with Potency Initially Inert Compounds with Good Bioavailability and Low Toxicity. Journal of chemical information and modeling (2024)
Samuel T Dada, Zenon Toprakcioglu, Mariana P Cali, Alexander Röntgen, Maarten C Hardenberg, Owen M Morris, Lena K Mrugalla, Tuomas P J Knowles, Christopher M Dobson
Pharmacological inhibition of α-synuclein aggregation within liquid condensates. Nature communications 15 (1) (2024)
Alicia González Díaz, Rodrigo Cataldi, Benedetta Mannini, Christopher M Dobson
Preparation and Characterization of Zn(II)-Stabilized Aβ 42 Oligomers. ACS chemical neuroscience (2024)
Samuel T Dada, Zenon Toprakcioglu, Mariana P Cali, Alexander Röntgen, Maarten C Hardenberg, Owen M Morris, Lena K Mrugalla, Tuomas P J Knowles, Christopher M Dobson
Pharmacological inhibition of α-synuclein aggregation within liquid condensates. Nature communications 15 (1) (2024)
Alicia González Díaz, Rodrigo Cataldi, Benedetta Mannini, Christopher M Dobson
Preparation and Characterization of Zn(II)-Stabilized Aβ 42 Oligomers. ACS chemical neuroscience 15 (14) (2024)
Robert I Horne, Jared Wilson-Godber, Alicia González Díaz, Z Faidon Brotzakis, Srijit Seal, Rebecca C Gregory, Andrea Possenti, Sean Chia, Christopher M Dobson
Using Generative Modeling to Endow with Potency Initially Inert Compounds with Good Bioavailability and Low Toxicity. Journal of chemical information and modeling 64 (3) (2024)
Udit Surya Saha, Christopher M Dobson, Anne E Carpenter, Shantanu Singh, Andreas Bender, Srijit Seal
Step Forward Cross Validation for Bioactivity Prediction: Out of Distribution Validation in Drug Discovery. bioRxiv : the preprint server for biology (2024)
Sean Chia, Rodrigo Lessa Cataldi, Francesco Simone Ruggeri, Ryan Limbocker, Itzel Condado-Morales, Katarina Pisani, Andrea Possenti, Sara Linse, Tuomas P J Knowles, Johnny Habchi, Benedetta Mannini, Christopher M Dobson
A Relationship between the Structures and Neurotoxic Effects of Aβ Oligomers Stabilized by Different Metal Ions. ACS chemical neuroscience 15 (6) (2024)
Robert I Horne, Jared Wilson-Godber, Alicia González Díaz, Z Faidon Brotzakis, Srijit Seal, Rebecca C Gregory, Andrea Possenti, Sean Chia, Christopher M Dobson
Using Generative Modeling to Endow with Potency Initially Inert Compounds with Good Bioavailability and Low Toxicity. Journal of chemical information and modeling 64 (3) (2024)
Bin Fu, Emma E Brock, Rebecca Andrews, Jonathan C Breiter, Ru Tian, Christina E Toomey, Joanne Lachica, Tammaryn Lashley, Mina Ryten, Nicholas W Wood, Christopher M Dobson, Sonia Gandhi, Lucien E Weiss, Joseph S Beckwith, Steven F Lee
RASP: Optimal Single Puncta Detection in Complex Cellular Backgrounds. The journal of physical chemistry. B 128 (15) (2024)
Alyssa Miller, Sean Chia, Ewa Klimont, Tuomas P J Knowles, Christopher M Dobson, Francesco Simone Ruggeri
Maturation-dependent changes in the size, structure and seeding capacity of Aβ42 amyloid fibrils. Communications biology 7 (1) (2024)
Bin Fu, Emma E Brock, Rebecca Andrews, Jonathan C Breiter, Ru Tian, Christina E Toomey, Joanne Lachica, Tammaryn Lashley, Mina Ryten, Nicholas W Wood, Christopher M Dobson, Sonia Gandhi, Lucien E Weiss, Joseph S Beckwith, Steven F Lee
RASP: Optimal Single Puncta Detection in Complex Cellular Backgrounds. The journal of physical chemistry. B 128 (15) (2024)
Bin Fu, Emma E Brock, Rebecca Andrews, Jonathan C Breiter, Ru Tian, Christina E Toomey, Joanne Lachica, Tammaryn Lashley, Mina Ryten, Nicholas W Wood, Christopher M Dobson, Sonia Gandhi, Lucien E Weiss, Joseph S Beckwith, Steven F Lee
RASP: Optimal Single Puncta Detection in Complex Cellular Backgrounds. The journal of physical chemistry. B 128 (15) (2024)
Robert I Horne, Ewa A Andrzejewska, Parvez Alam, Z Faidon Brotzakis, Ankit Srivastava, Alice Aubert, Magdalena Nowinska, Rebecca C Gregory, Roxine Staats, Andrea Possenti, Sean Chia, Pietro Sormanni, Bernardino Ghetti, Byron Caughey, Tuomas P J Knowles, Christopher M Dobson
Discovery of potent inhibitors of α-synuclein aggregation using structure-based iterative learning. Nature chemical biology 20 (5) (2024)
Sean Chia, Rodrigo Lessa Cataldi, Francesco Simone Ruggeri, Ryan Limbocker, Itzel Condado-Morales, Katarina Pisani, Andrea Possenti, Sara Linse, Tuomas P J Knowles, Johnny Habchi, Benedetta Mannini, Christopher M Dobson
A Relationship between the Structures and Neurotoxic Effects of Aβ Oligomers Stabilized by Different Metal Ions. ACS chemical neuroscience (2024)
Robert I Horne, Ewa A Andrzejewska, Parvez Alam, Z Faidon Brotzakis, Ankit Srivastava, Alice Aubert, Magdalena Nowinska, Rebecca C Gregory, Roxine Staats, Andrea Possenti, Sean Chia, Pietro Sormanni, Bernardino Ghetti, Byron Caughey, Tuomas P J Knowles, Christopher M Dobson
Discovery of potent inhibitors of α-synuclein aggregation using structure-based iterative learning. Nature chemical biology (2024)
Alyssa Miller, Sean Chia, Ewa Klimont, Tuomas P J Knowles, Christopher M Dobson, Francesco Simone Ruggeri
Maturation-dependent changes in the size, structure and seeding capacity of Aβ42 amyloid fibrils. Communications biology 7 (1) (2024)
Alicia González Díaz, Rodrigo Cataldi, Benedetta Mannini, Christopher M Dobson
Preparation and Characterization of Zn(II)-Stabilized Aβ 42 Oligomers. ACS chemical neuroscience 15 (14) (2024)
Cristina Olivieri, Yingjie Wang, Caitlin Walker, Manu Veliparambil Subrahmanian, Kim N Ha, David Bernlohr, Jiali Gao, Carlo Camilloni, Christopher M Dobson, Susan S Taylor, Gianluigi Veglia
The αC-β4 loop controls the allosteric cooperativity between nucleotide and substrate in the catalytic subunit of protein kinase A. eLife 12 (2024)
Alexander Röntgen, Zenon Toprakcioglu, James E Tomkins, Christopher M Dobson
Modulation of α-synuclein in vitro aggregation kinetics by its alternative splice isoforms. Proceedings of the National Academy of Sciences of the United States of America 121 (7) (2024)
Robert I Horne, Jared Wilson-Godber, Alicia González Díaz, Z Faidon Brotzakis, Srijit Seal, Rebecca C Gregory, Andrea Possenti, Sean Chia, Christopher M Dobson
Using Generative Modeling to Endow with Potency Initially Inert Compounds with Good Bioavailability and Low Toxicity. Journal of chemical information and modeling 64 (3) (2024)
Bin Fu, Emma E Brock, Rebecca Andrews, Jonathan C Breiter, Ru Tian, Christina E Toomey, Joanne Lachica, Tammaryn Lashley, Mina Ryten, Nicholas W Wood, Christopher M Dobson, Sonia Gandhi, Lucien E Weiss, Joseph S Beckwith, Steven F Lee
RASP: Optimal Single Puncta Detection in Complex Cellular Backgrounds. The journal of physical chemistry. B 128 (15) (2024)
Robert I Horne, Jared Wilson-Godber, Alicia González Díaz, Z Faidon Brotzakis, Srijit Seal, Rebecca C Gregory, Andrea Possenti, Sean Chia, Christopher M Dobson
Using Generative Modeling to Endow with Potency Initially Inert Compounds with Good Bioavailability and Low Toxicity. Journal of chemical information and modeling 64 (3) (2024)
Alexander Röntgen, Zenon Toprakcioglu, James E Tomkins, Christopher M Dobson
Modulation of α-synuclein in vitro aggregation kinetics by its alternative splice isoforms. Proceedings of the National Academy of Sciences of the United States of America 121 (7) (2024)
Bin Fu, Emma E Brock, Rebecca Andrews, Jonathan C Breiter, Ru Tian, Christina E Toomey, Joanne Lachica, Tammaryn Lashley, Mina Ryten, Nicholas W Wood, Christopher M Dobson, Sonia Gandhi, Lucien E Weiss, Joseph S Beckwith, Steven F Lee
RASP: Optimal Single Puncta Detection in Complex Cellular Backgrounds. The journal of physical chemistry. B (2024)
Nadia A Erkamp, Marc Oeller, Tomas Sneideris, Hannes Ausserwoger, Aviad Levin, Timothy J Welsh, Runzhang Qi, Daoyuan Qian, Nikolai Lorenzen, Hongjia Zhu, Pietro Sormanni, Christopher M Dobson, Tuomas P J Knowles
Multidimensional Protein Solubility Optimization with an Ultrahigh-Throughput Microfluidic Platform. Analytical chemistry (2023)
Alyssa Miller, Jiapeng Wei, Sarah Meehan, Christopher M Dobson, Mark E Welland, David Klenerman, Christopher M Dobson, Francesco Simone Ruggeri, Tuomas P J Knowles
Formation of amyloid loops in brain tissues is controlled by the flexibility of protofibril chains. Proceedings of the National Academy of Sciences of the United States of America 120 (21) (2023)
Samuel T Dada, Maarten C Hardenberg, Zenon Toprakcioglu, Lena K Mrugalla, Mariana P Cali, Mollie O McKeon, Ewa Klimont, Thomas C T Michaels, Tuomas P J Knowles, Christopher M Dobson
Spontaneous nucleation and fast aggregate-dependent proliferation of α-synuclein aggregates within liquid condensates at neutral pH. Proceedings of the National Academy of Sciences of the United States of America 120 (9) (2023)
Taniya Bhardwaj, Kundlik Gadhave, Shivani K Kapuganti, Prateek Kumar, Zacharias Faidon Brotzakis, Kumar Udit Saumya, Namyashree Nayak, Ankur Kumar, Richa Joshi, Bodhidipra Mukherjee, Aparna Bhardwaj, Krishan Gopal Thakur, Neha Garg, Christopher M Dobson, Rajanish Giri
Amyloidogenic proteins in the SARS-CoV and SARS-CoV-2 proteomes. Nature communications 14 (1) (2023)
Raghav Chandra, Robert I Horne, Christopher M Dobson
Bayesian Optimization in the Latent Space of a Variational Autoencoder for the Generation of Selective FLT3 Inhibitors. Journal of chemical theory and computation 20 (1) (2023)
Christopher M Dobson
Thermodynamic and kinetic approaches for drug discovery to target protein misfolding and aggregation. Expert opinion on drug discovery (2023)
Priyanka Joshi, Sean Chia, Xiaoting Yang, Michele Perni, Justus M Gabriel, Marshall Gilmer, Ryan Limbocker, Johnny Habchi, Christopher M Dobson
Combinations of Vitamin A and Vitamin E Metabolites Confer Resilience against Amyloid-β Aggregation. ACS chemical neuroscience 14 (4) (2023)
Raghav Chandra, Robert I Horne, Christopher M Dobson
Bayesian Optimization in the Latent Space of a Variational Autoencoder for the Generation of Selective FLT3 Inhibitors. Journal of chemical theory and computation 20 (1) (2023)
Alyssa Miller, Jiapeng Wei, Sarah Meehan, Christopher M Dobson, Mark E Welland, David Klenerman, Christopher M Dobson, Francesco Simone Ruggeri, Tuomas P J Knowles
Formation of amyloid loops in brain tissues is controlled by the flexibility of protofibril chains. Proceedings of the National Academy of Sciences of the United States of America 120 (21) (2023)
Priyanka Joshi, Sean Chia, Xiaoting Yang, Michele Perni, Justus M Gabriel, Marshall Gilmer, Ryan Limbocker, Johnny Habchi, Christopher M Dobson
Combinations of Vitamin A and Vitamin E Metabolites Confer Resilience against Amyloid-β Aggregation. ACS chemical neuroscience (2023)
Raghav Chandra, Robert I Horne, Christopher M Dobson
Bayesian Optimization in the Latent Space of a Variational Autoencoder for the Generation of Selective FLT3 Inhibitors. Journal of chemical theory and computation 20 (1) (2023)
Priyanka Joshi, Sean Chia, Xiaoting Yang, Michele Perni, Justus M Gabriel, Marshall Gilmer, Ryan Limbocker, Johnny Habchi, Christopher M Dobson
Combinations of Vitamin A and Vitamin E Metabolites Confer Resilience against Amyloid-β Aggregation. ACS chemical neuroscience 14 (4) (2023)
Samuel T Dada, Maarten C Hardenberg, Zenon Toprakcioglu, Lena K Mrugalla, Mariana P Cali, Mollie O McKeon, Ewa Klimont, Thomas C T Michaels, Tuomas P J Knowles, Christopher M Dobson
Spontaneous nucleation and fast aggregate-dependent proliferation of α-synuclein aggregates within liquid condensates at neutral pH. Proceedings of the National Academy of Sciences of the United States of America 120 (9) (2023)
Taniya Bhardwaj, Kundlik Gadhave, Shivani K Kapuganti, Prateek Kumar, Zacharias Faidon Brotzakis, Kumar Udit Saumya, Namyashree Nayak, Ankur Kumar, Richa Joshi, Bodhidipra Mukherjee, Aparna Bhardwaj, Krishan Gopal Thakur, Neha Garg, Christopher M Dobson, Rajanish Giri
Amyloidogenic proteins in the SARS-CoV and SARS-CoV-2 proteomes. Nature communications 14 (1) (2023)
Christine M Lim, Alicia González Díaz, Monika Fuxreiter, Frank W Pun, Alex Zhavoronkov, Christopher M Dobson
Multiomic prediction of therapeutic targets for human diseases associated with protein phase separation. Proceedings of the National Academy of Sciences of the United States of America 120 (40) (2023)
Robert I Horne, Michael A Metrick, Wing Man, Dillon J Rinauro, Z Faidon Brotzakis, Sean Chia, Georg Meisl, Christopher M Dobson
Secondary Processes Dominate the Quiescent, Spontaneous Aggregation of α-Synuclein at Physiological pH with Sodium Salts. ACS chemical neuroscience (2023)
Mark R Wilson, Sandeep Satapathy, Christopher M Dobson
Extracellular protein homeostasis in neurodegenerative diseases. Nature reviews. Neurology (2023)
Andras Hatos, João Mc Teixeira, Susana Barrera-Vilarmau, Attila Horvath, Silvio C E Tosatto, Christopher M Dobson, Monika Fuxreiter
FuzPred: a web server for the sequence-based prediction of the context-dependent binding modes of proteins. Nucleic acids research (2023)
Marc Oeller, Ryan Kang, Rosie Bell, Hannes Ausserwöger, Pietro Sormanni, Christopher M Dobson
Sequence-based prediction of pH-dependent protein solubility using CamSol. Briefings in bioinformatics (2023)
Sarah E Sandler, Robert I Horne, Sara Rocchetti, Robert Novak, Nai-Shu Hsu, Marta Castellana Cruz, Z Faidon Brotzakis, Rebecca C Gregory, Sean Chia, Gonçalo J L Bernardes, Ulrich F Keyser, Christopher M Dobson
Multiplexed Digital Characterization of Misfolded Protein Oligomers via Solid-State Nanopores. Journal of the American Chemical Society (2023)
Marc Oeller, Ryan Kang, Rosie Bell, Hannes Ausserwöger, Pietro Sormanni, Christopher M Dobson
Sequence-based prediction of pH-dependent protein solubility using CamSol. Briefings in bioinformatics 24 (2) (2023)
Jonathon Nixon-Abell, Francesco Simone Ruggeri, Seema Qamar, Therese W Herling, Magdalena A Czekalska, Yi Shen, Guozhen Wang, Christopher King, Michael S Fernandopulle, Tomas Šneideris, Joseph L Watson, Visakh V S Pillai, William Meadows, James W Henderson, Joseph E Chambers, Jane L Wagstaff, Sioned H Williams, Helena Coyle, Yuqian Lu, Shuyuan Zhang, Stefan John Marciniak, Stefan M V Freund, Emmanuel Derivery, Michael Emmerson Ward, Christopher M Dobson, Tuomas P J Knowles, Peter St George-Hyslop
ANXA11 biomolecular condensates facilitate protein-lipid phase coupling on lysosomal membranes. bioRxiv : the preprint server for biology (2023)
Marc Oeller, Ryan J D Kang, Hannah L Bolt, Ana L Gomes Dos Santos, Annika Langborg Weinmann, Antonios Nikitidis, Pavol Zlatoidsky, Wu Su, Werngard Czechtizky, Leonardo De Maria, Pietro Sormanni, Christopher M Dobson
Sequence-based prediction of the intrinsic solubility of peptides containing non-natural amino acids. Nature communications 14 (1) (2023)
Alyssa Miller, Sean Chia, Zenon Toprakcioglu, Tuuli A Hakala, Roman Schmid, Yaduo Feng, Tadas Kartanas, Ayaka Kamada, Christopher M Dobson, Francesco Simone Ruggeri, Tuomas P J Knowles
Enhanced surface nanoanalytics of transient biomolecular processes. Science advances 9 (2) (2023)
Ryan Limbocker, Nunilo Cremades, Roberta Cascella, Peter M Tessier, Christopher M Dobson, Fabrizio Chiti
Characterization of Pairs of Toxic and Nontoxic Misfolded Protein Oligomers Elucidates the Structural Determinants of Oligomer Toxicity in Protein Misfolding Diseases. Accounts of chemical research (2023)
Taniya Bhardwaj, Kundlik Gadhave, Shivani K Kapuganti, Prateek Kumar, Zacharias Faidon Brotzakis, Kumar Udit Saumya, Namyashree Nayak, Ankur Kumar, Richa Joshi, Bodhidipra Mukherjee, Aparna Bhardwaj, Krishan Gopal Thakur, Neha Garg, Christopher M Dobson, Rajanish Giri
Amyloidogenic proteins in the SARS-CoV and SARS-CoV-2 proteomes. Nature communications 14 (1) (2023)
Nadia A Erkamp, Marc Oeller, Tomas Sneideris, Hannes Ausserwoger, Aviad Levin, Timothy J Welsh, Runzhang Qi, Daoyuan Qian, Nikolai Lorenzen, Hongjia Zhu, Pietro Sormanni, Christopher M Dobson, Tuomas P J Knowles
Multidimensional Protein Solubility Optimization with an Ultrahigh-Throughput Microfluidic Platform. Analytical chemistry (2023)
Samuel T Dada, Maarten C Hardenberg, Zenon Toprakcioglu, Lena K Mrugalla, Mariana P Cali, Mollie O McKeon, Ewa Klimont, Thomas C T Michaels, Tuomas P J Knowles, Christopher M Dobson
Spontaneous nucleation and fast aggregate-dependent proliferation of α-synuclein aggregates within liquid condensates at neutral pH. Proceedings of the National Academy of Sciences of the United States of America 120 (9) (2023)
Z Faidon Brotzakis, Thomas Löhr, Steven D Truong, Samuel Hoff, Massimiliano Bonomi, Christopher M Dobson
Determination of the Structure and Dynamics of the Fuzzy Coat of an Amyloid Fibril of IAPP Using Cryo-Electron Microscopy. Biochemistry (2023)
Priyanka Joshi, Sean Chia, Xiaoting Yang, Michele Perni, Justus M Gabriel, Marshall Gilmer, Ryan Limbocker, Johnny Habchi, Christopher M Dobson
Combinations of Vitamin A and Vitamin E Metabolites Confer Resilience against Amyloid-β Aggregation. ACS chemical neuroscience 14 (4) (2023)
Alyssa Miller, Sean Chia, Zenon Toprakcioglu, Tuuli A Hakala, Roman Schmid, Yaduo Feng, Tadas Kartanas, Ayaka Kamada, Christopher M Dobson, Francesco Simone Ruggeri, Tuomas P J Knowles
Enhanced surface nanoanalytics of transient biomolecular processes. Science advances 9 (2) (2023)
Raghav Chandra, Robert I Horne, Christopher M Dobson
Bayesian Optimization in the Latent Space of a Variational Autoencoder for the Generation of Selective FLT3 Inhibitors. Journal of chemical theory and computation (2023)
Priyanka Joshi, Sean Chia, Xiaoting Yang, Michele Perni, Justus M Gabriel, Marshall Gilmer, Ryan Limbocker, Johnny Habchi, Christopher M Dobson
Combinations of Vitamin A and Vitamin E Metabolites Confer Resilience against Amyloid-β Aggregation. ACS chemical neuroscience 14 (4) (2023)
Robert I Horne, Mhd Hussein Murtada, Donghui Huo, Z Faidon Brotzakis, Rebecca C Gregory, Andrea Possenti, Sean Chia, Christopher M Dobson
Exploration and Exploitation Approaches Based on Generative Machine Learning to Identify Potent Small Molecule Inhibitors of α-Synuclein Secondary Nucleation. Journal of chemical theory and computation (2023)
Raghav Chandra, Robert I Horne, Christopher M Dobson
Bayesian Optimization in the Latent Space of a Variational Autoencoder for the Generation of Selective FLT3 Inhibitors. Journal of chemical theory and computation 20 (1) (2023)
Samuel T Dada, Maarten C Hardenberg, Zenon Toprakcioglu, Lena K Mrugalla, Mariana P Cali, Mollie O McKeon, Ewa Klimont, Thomas C T Michaels, Tuomas P J Knowles, Christopher M Dobson
Spontaneous nucleation and fast aggregate-dependent proliferation of α-synuclein aggregates within liquid condensates at neutral pH. Proceedings of the National Academy of Sciences of the United States of America 120 (9) (2023)
Priyanka Joshi, Sean Chia, Xiaoting Yang, Michele Perni, Justus M Gabriel, Marshall Gilmer, Ryan Limbocker, Johnny Habchi, Christopher M Dobson
Combinations of Vitamin A and Vitamin E Metabolites Confer Resilience against Amyloid-β Aggregation. ACS chemical neuroscience 14 (4) (2023)
Alyssa Miller, Jiapeng Wei, Sarah Meehan, Christopher M Dobson, Mark E Welland, David Klenerman, Christopher M Dobson, Francesco Simone Ruggeri, Tuomas P J Knowles
Formation of amyloid loops in brain tissues is controlled by the flexibility of protofibril chains. Proceedings of the National Academy of Sciences of the United States of America 120 (21) (2023)
Silvia Errico, Giacomo Lucchesi, Davide Odino, Enass Youssef Osman, Roberta Cascella, Lorenzo Neri, Claudia Capitini, Martino Calamai, Francesco Bemporad, Cristina Cecchi, William A Kinney, Denise Barbut, Annalisa Relini, Claudio Canale, Gabriella Caminati, Ryan Limbocker, Christopher M Dobson, Michael Zasloff, Fabrizio Chiti
Quantitative Attribution of the Protective Effects of Aminosterols against Protein Aggregates to Their Chemical Structures and Ability to Modulate Biological Membranes. Journal of medicinal chemistry (2023)
Priyanka Joshi, Sean Chia, Xiaoting Yang, Michele Perni, Justus M Gabriel, Marshall Gilmer, Ryan Limbocker, Johnny Habchi, Christopher M Dobson
Combinations of Vitamin A and Vitamin E Metabolites Confer Resilience against Amyloid-β Aggregation. ACS chemical neuroscience 14 (4) (2023)
Marc Oeller, Ryan Kang, Rosie Bell, Hannes Ausserwöger, Pietro Sormanni, Christopher M Dobson
Sequence-based prediction of pH-dependent protein solubility using CamSol. Briefings in bioinformatics 24 (2) (2023)
Alyssa Miller, Sean Chia, Zenon Toprakcioglu, Tuuli A Hakala, Roman Schmid, Yaduo Feng, Tadas Kartanas, Ayaka Kamada, Christopher M Dobson, Francesco Simone Ruggeri, Tuomas P J Knowles
Enhanced surface nanoanalytics of transient biomolecular processes. Science advances 9 (2) (2023)
Taniya Bhardwaj, Kundlik Gadhave, Shivani K Kapuganti, Prateek Kumar, Zacharias Faidon Brotzakis, Kumar Udit Saumya, Namyashree Nayak, Ankur Kumar, Richa Joshi, Bodhidipra Mukherjee, Aparna Bhardwaj, Krishan Gopal Thakur, Neha Garg, Christopher M Dobson, Rajanish Giri
Amyloidogenic proteins in the SARS-CoV and SARS-CoV-2 proteomes. Nature communications 14 (1) (2023)
Andras Hatos, Silvio C E Tosatto, Christopher M Dobson, Monika Fuxreiter
FuzDrop on AlphaFold: visualizing the sequence-dependent propensity of liquid-liquid phase separation and aggregation of proteins. Nucleic acids research (2022)
Attila Horvath, Christopher M Dobson, Monika Fuxreiter
Sequence-based Prediction of the Cellular Toxicity Associated with Amyloid Aggregation within Protein Condensates. Biochemistry 61 (22) (2022)
Thomas Löhr, Pietro Sormanni, Christopher M Dobson
Conformational Entropy as a Potential Liability of Computationally Designed Antibodies. Biomolecules 12 (5) (2022)
Derya Emin, Yu P Zhang, Evgeniia Lobanova, Alyssa Miller, Xuecong Li, Zengjie Xia, Helen Dakin, Dimitrios I Sideris, Jeff Y L Lam, Rohan T Ranasinghe, Antonina Kouli, Yanyan Zhao, Suman De, Tuomas P J Knowles, Christopher M Dobson, Francesco Simone Ruggeri, Franklin I Aigbirhio, Caroline H Williams-Gray, David Klenerman
Small soluble α-synuclein aggregates are the toxic species in Parkinson's disease. Nature communications 13 (1) (2022)
Klara Kulenkampff, Derya Emin, Roxine Staats, Yu P Zhang, Laila Sakhnini, Antonina Kouli, Oded Rimon, Evgeniia Lobanova, Caroline H Williams-Gray, Francesco A Aprile, Pietro Sormanni, David Klenerman, Christopher M Dobson
An antibody scanning method for the detection of α-synuclein oligomers in the serum of Parkinson's disease patients. Chemical science 13 (46) (2022)
Thomas Löhr, Kai Kohlhoff, Gabriella T Heller, Carlo Camilloni, Christopher M Dobson
A Small Molecule Stabilizes the Disordered Native State of the Alzheimer's Aβ Peptide. ACS chemical neuroscience 13 (12) (2022)

Christopher M Dobson.css-eqlu8i{font-size:small;padding-left:4px;} (Michele Vendruscolo)

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Christopher M Dobson (Michele Vendruscolo)