Lhassane Ismaili

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 24

Top Topics

Traumatic Brain Injury

Top Venues

Molecules (Basel, Switzerland)

Future medicinal chemistry

International journal of molecular sciences

This page only lists publications with an associated author ORCID identifier.

Publications

Irene Pachón-Angona, Paul J Bernard, Alexey Simakov, Maciej Maj, Krzysztof Jozwiak, Anna Novotna, Carina Lemke, Michael Gütschow, Helene Martin, María Jesús Oset-Gasque, José-Marco Contelles, Lhassane Ismaili
Design and Synthesis of Multi-Functional Ligands through Hantzsch Reaction: Targeting Ca 2+ Channels, Activating Nrf2 and Possessing Cathepsin S Inhibitory, and Antioxidant Properties. Pharmaceutics 16 (1) (2024)
Irene Pachón-Angona, Paul J Bernard, Alexey Simakov, Maciej Maj, Krzysztof Jozwiak, Anna Novotna, Carina Lemke, Michael Gütschow, Helene Martin, María Jesús Oset-Gasque, José-Marco Contelles, Lhassane Ismaili
Design and Synthesis of Multi-Functional Ligands through Hantzsch Reaction: Targeting Ca 2+ Channels, Activating Nrf2 and Possessing Cathepsin S Inhibitory, and Antioxidant Properties. Pharmaceutics 16 (1) (2024)
Rim Malek, Kinga Sałat, Perle Totoson, Tadeusz Karcz, Bernard Refouvelet, Anna Skrzypczak-Wiercioch, Maciej Maj, Alexey Simakov, Helene Martin, Agata Siwek, Natalia Szałaj, Justyna Godyń, Dawid Panek, Anna Więckowska, Krzysztof Jozwiak, Celine Demougeot, Katarzyna Kieć-Kononowicz, Fakher Chabchoub, Isabel Iriepa, José Marco-Contelles, Lhassane Ismaili
Discovery of New Highly Potent Histamine H 3 Receptor Antagonists, Calcium Channel Blockers, and Acetylcholinesterase Inhibitors. ACS chemical neuroscience (2024)
Irene Pachón-Angona, Paul J Bernard, Alexey Simakov, Maciej Maj, Krzysztof Jozwiak, Anna Novotna, Carina Lemke, Michael Gütschow, Helene Martin, María Jesús Oset-Gasque, José-Marco Contelles, Lhassane Ismaili
Design and Synthesis of Multi-Functional Ligands through Hantzsch Reaction: Targeting Ca 2+ Channels, Activating Nrf2 and Possessing Cathepsin S Inhibitory, and Antioxidant Properties. Pharmaceutics 16 (1) (2024)
Emelina R Rodríguez-Ruiz, Raquel Herrero-Labrador, Ana P Fernández-Fernández, Julia Serrano-Masa, José A Martínez-Montero, Daniel González-Nieto, Mayuri Hana-Vaish, Mohamed Benchekroun, Lhassane Ismaili, José Marco-Contelles, Ricardo Martínez-Murillo
The Proof-of-Concept of MBA121, a Tacrine-Ferulic Acid Hybrid, for Alzheimer's Disease Therapy. International journal of molecular sciences 24 (15) (2023)
Imen Dakhlaoui, Paul J Bernard, Diana Pietrzak, Alexey Simakov, Maciej Maj, Bernard Refouvelet, Arnaud Béduneau, Raphaël Cornu, Krzysztof Jozwiak, Fakher Chabchoub, Isabel Iriepa, Helene Martin, José Marco-Contelles, Lhassane Ismaili
Exploring the Potential of Sulfonamide-Dihydropyridine Hybrids as Multitargeted Ligands for Alzheimer's Disease Treatment. International journal of molecular sciences 24 (11) (2023)
Sylvain Grosjean, Irene Pachón-Angona, Michella Dawra, Bernard Refouvelet, Lhassane Ismaili
Multicomponent reactions as a privileged tool for multitarget-directed ligand strategies in Alzheimer's disease therapy. Future medicinal chemistry 14 (21) (2022)
Rim Malek, Alexey Simakov, Audrey Davis, Maciej Maj, Paul J Bernard, Artur Wnorowski, Helene Martin, José Marco-Contelles, Fakher Chabchoub, Patrick Dallemagne, Christophe Rochais, Krzysztof Jozwiak, Lhassane Ismaili
Biginelli Reaction Synthesis of Novel Multitarget-Directed Ligands with Ca 2+ Channel Blocking Ability, Cholinesterase Inhibition, Antioxidant Capacity, and Nrf2 Activation. Molecules (Basel, Switzerland) 28 (1) (2022)
Rim Malek, Alexey Simakov, Audrey Davis, Maciej Maj, Paul J Bernard, Artur Wnorowski, Helene Martin, José Marco-Contelles, Fakher Chabchoub, Patrick Dallemagne, Christophe Rochais, Krzysztof Jozwiak, Lhassane Ismaili
Biginelli Reaction Synthesis of Novel Multitarget-Directed Ligands with Ca 2+ Channel Blocking Ability, Cholinesterase Inhibition, Antioxidant Capacity, and Nrf2 Activation. Molecules (Basel, Switzerland) 28 (1) (2022)
Rim Malek, Alexey Simakov, Audrey Davis, Maciej Maj, Paul J Bernard, Artur Wnorowski, Helene Martin, José Marco-Contelles, Fakher Chabchoub, Patrick Dallemagne, Christophe Rochais, Krzysztof Jozwiak, Lhassane Ismaili
Biginelli Reaction Synthesis of Novel Multitarget-Directed Ligands with Ca 2+ Channel Blocking Ability, Cholinesterase Inhibition, Antioxidant Capacity, and Nrf2 Activation. Molecules (Basel, Switzerland) 28 (1) (2022)
Emna Choura, Fares Elghali, Paul J Bernard, Dhouha Msalbi, José Marco-Contelles, Sami Aifa, Lhassane Ismaili, Fakher Chabchoub
Benzochromenopyrimidines: Synthesis, Antiproliferative Activity against Colorectal Cancer and Physicochemical Properties. Molecules (Basel, Switzerland) 27 (22) (2022)
Lhassane Ismaili, Paul J Bernard, Bernard Refouvelet
Latest progress in the development of multitarget ligands for Alzheimer's disease based on the Hantzsch reaction. Future medicinal chemistry 14 (13) (2022)
Rim Malek, Alexey Simakov, Audrey Davis, Maciej Maj, Paul J Bernard, Artur Wnorowski, Helene Martin, José Marco-Contelles, Fakher Chabchoub, Patrick Dallemagne, Christophe Rochais, Krzysztof Jozwiak, Lhassane Ismaili
Biginelli Reaction Synthesis of Novel Multitarget-Directed Ligands with Ca 2+ Channel Blocking Ability, Cholinesterase Inhibition, Antioxidant Capacity, and Nrf2 Activation. Molecules (Basel, Switzerland) 28 (1) (2022)
Rim Malek, Alexey Simakov, Audrey Davis, Maciej Maj, Paul J Bernard, Artur Wnorowski, Helene Martin, José Marco-Contelles, Fakher Chabchoub, Patrick Dallemagne, Christophe Rochais, Krzysztof Jozwiak, Lhassane Ismaili
Biginelli Reaction Synthesis of Novel Multitarget-Directed Ligands with Ca 2+ Channel Blocking Ability, Cholinesterase Inhibition, Antioxidant Capacity, and Nrf2 Activation. Molecules (Basel, Switzerland) 28 (1) (2022)
Lhassane Ismaili, Julie Monnin, Adeline Etievant, Raquel L Arribas, Lucía Viejo, Bernard Refouvelet, Ondrej Soukup, Jana Janockova, Vendula Hepnarova, Jan Korabecny, Tomas Kucera, Daniel Jun, Rudolf Andrys, Kamil Musilek, Aurelie Baguet, Eva M García-Frutos, Angela De Simone, Vincenza Andrisano, Manuela Bartolini, Cristóbal de Los Ríos, José Marco-Contelles, Emmanuel Haffen
(±)-BIGI-3h: Pentatarget-Directed Ligand combining Cholinesterase, Monoamine Oxidase, and Glycogen Synthase Kinase 3β Inhibition with Calcium Channel Antagonism and Antiaggregating Properties for Alzheimer's Disease. ACS chemical neuroscience 12 (8) (2021)
Irene Pachón-Angona, Maciej Maj, Artur Wnorowski, Helene Martin, Lhassane Ismaili
Synthesis of new Hantzsch adducts showing Ca2+ channel blockade capacity, cholinesterase inhibition and antioxidant power. Future medicinal chemistry 13 (20) (2021)
Irene Pachón Angona, Helene Martin, Solene Daniel, Ignacio Moraleda, Alexandre Bonet, Artur Wnorowski, Maciej Maj, Krzysztof Jozwiak, Isabel Iriepa, Bernard Refouvelet, José Marco-Contelles, Lhassane Ismaili
Synthesis of Hantzsch Adducts as Cholinesterases and Calcium Flux inhibitors, Antioxidants and Neuroprotectives. International journal of molecular sciences 21 (20) (2020)
Óscar M Bautista-Aguilera, Lhassane Ismaili, Mourad Chioua, Rudolf Andrys, Monika Schmidt, Petr Bzonek, María Ángeles Martínez-Grau, Christopher D Beadle, Tatiana Vetman, Francisco López Muñoz, Isabel Iriepa, Bernard Refouvelet, Kamil Musilek, José Marco-Contelles
Acetylcholinesterase Inhibition of Diversely Functionalized Quinolinones for Alzheimer's Disease Therapy. International journal of molecular sciences 21 (11) (2020)
Lazhar Zribi, Irene Pachòn-Angona, Óscar M Bautista-Aguilera, Daniel Diez-Iriepa, José Marco-Contelles, Lhassane Ismaili, Isabel Iriepa, Fakher Chabchoub
Triazolopyridopyrimidine: A New Scaffold for Dual-Target Small Molecules for Alzheimer's Disease Therapy. Molecules (Basel, Switzerland) 25 (14) (2020)
Irene Pachón-Angona, Helène Martin, Stecy Chhor, María-Jesús Oset-Gasque, Bernard Refouvelet, José Marco-Contelles, Lhassane Ismaili
Synthesis of new ferulic/lipoic/comenic acid-melatonin hybrids as antioxidants and Nrf2 activators via Ugi reaction. Future medicinal chemistry 11 (24) (2020)
Youssef Dgachi, Hélène Martin, Rim Malek, Daniel Jun, Jana Janockova, Vendula Sepsova, Ondrej Soukup, Isabel Iriepa, Ignacio Moraleda, Emna Maalej, M Carmo Carreiras, Bernard Refouvelet, Fakher Chabchoub, José Marco-Contelles, Lhassane Ismaili
Synthesis and biological assessment of KojoTacrines as new agents for Alzheimer's disease therapy. Journal of enzyme inhibition and medicinal chemistry 34 (1) (2019)
Irene Pachón-Angona, Bernard Refouvelet, Rudolf Andrýs, Helène Martin, Vincent Luzet, Isabel Iriepa, Ignacio Moraleda, Daniel Diez-Iriepa, María-Jesús Oset-Gasque, José Marco-Contelles, Kamil Musilek, Lhassane Ismaili
Donepezil + chromone + melatonin hybrids as promising agents for Alzheimer's disease therapy. Journal of enzyme inhibition and medicinal chemistry 34 (1) (2019)
Rim Malek, Raquel L Arribas, Alejandra Palomino-Antolin, Perle Totoson, Celine Demougeot, Tereza Kobrlova, Ondrej Soukup, Isabel Iriepa, Ignacio Moraleda, Daniel Diez-Iriepa, Justyna Godyń, Dawid Panek, Barbara Malawska, Monika Głuch-Lutwin, Barbara Mordyl, Agata Siwek, Fakher Chabchoub, José Marco-Contelles, Katarzyna Kiec-Kononowicz, Javier Egea, Cristóbal de Los Ríos, Lhassane Ismaili
New Dual Small Molecules for Alzheimer's Disease Therapy Combining Histamine H3 Receptor (H3R) Antagonism and Calcium Channels Blockade with Additional Cholinesterase Inhibition. Journal of medicinal chemistry 62 (24) (2019)
Óscar M Bautista-Aguilera, Stefanie Hagenow, Alejandra Palomino-Antolin, Víctor Farré-Alins, Lhassane Ismaili, Pierre-Louis Joffrin, M Luisa Jimeno, Ondrej Soukup, Jana Janočková, Lena Kalinowsky, Ewgenij Proschak, Isabel Iriepa, Ignacio Moraleda, Johannes S Schwed, Alejandro Romero Martínez, Francisco López-Muñoz, Mourad Chioua, Javier Egea, Rona R Ramsay, José Marco-Contelles, Holger Stark
Multitarget-Directed Ligands Combining Cholinesterase and Monoamine Oxidase Inhibition with Histamine H3 R Antagonism for Neurodegenerative Diseases. Angewandte Chemie (International ed. in English) 56 (41) (2017)