Michael Gütschow

ORCID

Publication Activity (10 Years)

Years Active: 2018-2024
Publications (10 Years): 78

Top Venues

Journal of medicinal chemistry

Pharmaceutics

ACS pharmacology & translational science

ACS chemical biology

University of Leipzig (PHD)

This page only lists publications with an associated author ORCID identifier.

Education History

University of Leipzig

Germany

PHD

Publications

Irene Pachón-Angona, Paul J Bernard, Alexey Simakov, Maciej Maj, Krzysztof Jozwiak, Anna Novotna, Carina Lemke, Michael Gütschow, Helene Martin, María Jesús Oset-Gasque, José-Marco Contelles, Lhassane Ismaili
Design and Synthesis of Multi-Functional Ligands through Hantzsch Reaction: Targeting Ca 2+ Channels, Activating Nrf2 and Possessing Cathepsin S Inhibitory, and Antioxidant Properties. Pharmaceutics 16 (1) (2024)
Julian Breidenbach, Rabea Voget, Yaoyao Si, Alexandra Hingst, Tobias Claff, Katharina Sylvester, Valentina Wolf, Vesa Krasniqi, Abibe Useini, Norbert Sträter, Yukino Ogura, Atsushi Kawaguchi, Christa Elisabeth Müller, Michael Gütschow
Macrocyclic Azapeptide Nitriles: Structure-Based Discovery of Potent SARS-CoV-2 Main Protease Inhibitors as Antiviral Drugs. Journal of medicinal chemistry 67 (11) (2024)
Julian Breidenbach, Rabea Voget, Yaoyao Si, Alexandra Hingst, Tobias Claff, Katharina Sylvester, Valentina Wolf, Vesa Krasniqi, Abibe Useini, Norbert Sträter, Yukino Ogura, Atsushi Kawaguchi, Christa Elisabeth Müller, Michael Gütschow
Macrocyclic Azapeptide Nitriles: Structure-Based Discovery of Potent SARS-CoV-2 Main Protease Inhibitors as Antiviral Drugs. Journal of medicinal chemistry (2024)
Philipp Flury, Julian Breidenbach, Nadine Krüger, Rabea Voget, Laura Schäkel, Yaoyao Si, Vesa Krasniqi, Sara Calistri, Matthias Olfert, Katharina Sylvester, Cheila Rocha, Raphael Ditzinger, Alexander Rasch, Stefan Pöhlmann, Thales Kronenberger, Antti Poso, Katharina Rox, Stefan A Laufer, Christa Elisabeth Müller, Michael Gütschow, Thanigaimalai Pillaiyar
Correction to "Cathepsin-Targeting SARS-CoV-2 Inhibitors: Design, Synthesis, and Biological Activity". ACS pharmacology & translational science 7 (4) (2024)
Irene Pachón-Angona, Paul J Bernard, Alexey Simakov, Maciej Maj, Krzysztof Jozwiak, Anna Novotna, Carina Lemke, Michael Gütschow, Helene Martin, María Jesús Oset-Gasque, José-Marco Contelles, Lhassane Ismaili
Design and Synthesis of Multi-Functional Ligands through Hantzsch Reaction: Targeting Ca 2+ Channels, Activating Nrf2 and Possessing Cathepsin S Inhibitory, and Antioxidant Properties. Pharmaceutics 16 (1) (2024)
Philipp Flury, Julian Breidenbach, Nadine Krüger, Rabea Voget, Laura Schäkel, Yaoyao Si, Vesa Krasniqi, Sara Calistri, Matthias Olfert, Katharina Sylvester, Cheila Rocha, Raphael Ditzinger, Alexander Rasch, Stefan Pöhlmann, Thales Kronenberger, Antti Poso, Katharina Rox, Stefan A Laufer, Christa Elisabeth Müller, Michael Gütschow, Thanigaimalai Pillaiyar
Cathepsin-Targeting SARS-CoV-2 Inhibitors: Design, Synthesis, and Biological Activity. ACS pharmacology & translational science 7 (2) (2024)
Yuki Yamauchi, Sho Konno, Noriko Omura, Narumi Yoshioka, Alexandra Hingst, Michael Gütschow, Christa Elisabeth Müller, Akihiro Taguchi, Atsuhiko Taniguchi, Atsushi Kawaguchi, Yoshio Hayashi
Detection of Active SARS-CoV-2 3CL Protease in Infected Cells Using Activity-Based Probes with a 2,6-Dichlorobenzoyloxymethyl Ketone Reactive Warhead. ACS chemical biology (2024)
Angelo Oneto, Ghazl Al Hamwi, Laura Schäkel, Nadine Krüger, Katharina Sylvester, Marvin Petry, Rasha Abu Shamleh, Thanigaimalai Pillaiyar, Tobias Claff, Anke C Schiedel, Norbert Sträter, Michael Gütschow, Christa Elisabeth Müller
Nonpeptidic Irreversible Inhibitors of SARS-CoV-2 Main Protease with Potent Antiviral Activity. Journal of medicinal chemistry (2024)
Yuki Yamauchi, Sho Konno, Noriko Omura, Narumi Yoshioka, Alexandra Hingst, Michael Gütschow, Christa Elisabeth Müller, Akihiro Taguchi, Atsuhiko Taniguchi, Atsushi Kawaguchi, Yoshio Hayashi
Detection of Active SARS-CoV-2 3CL Protease in Infected Cells Using Activity-Based Probes with a 2,6-Dichlorobenzoyloxymethyl Ketone Reactive Warhead. ACS chemical biology 19 (5) (2024)
Blaire E Barton, Matthew K Collins, Cindy H Chau, Hyoyoung Choo-Wosoba, David J Venzon, Christian Steinebach, Kathleen M Garchitorena, Bhruga Shah, Eric L Sarin, Michael Gütschow, William Douglas Figg
Preclinical Evaluation of a Novel Series of Polyfluorinated Thalidomide Analogs in Drug-Resistant Multiple Myeloma. Biomolecules 14 (6) (2024)
Julian Breidenbach, Rabea Voget, Yaoyao Si, Alexandra Hingst, Tobias Claff, Katharina Sylvester, Valentina Wolf, Vesa Krasniqi, Abibe Useini, Norbert Sträter, Yukino Ogura, Atsushi Kawaguchi, Christa Elisabeth Müller, Michael Gütschow
Macrocyclic Azapeptide Nitriles: Structure-Based Discovery of Potent SARS-CoV-2 Main Protease Inhibitors as Antiviral Drugs. Journal of medicinal chemistry (2024)
Irene Pachón-Angona, Paul J Bernard, Alexey Simakov, Maciej Maj, Krzysztof Jozwiak, Anna Novotna, Carina Lemke, Michael Gütschow, Helene Martin, María Jesús Oset-Gasque, José-Marco Contelles, Lhassane Ismaili
Design and Synthesis of Multi-Functional Ligands through Hantzsch Reaction: Targeting Ca 2+ Channels, Activating Nrf2 and Possessing Cathepsin S Inhibitory, and Antioxidant Properties. Pharmaceutics 16 (1) (2024)
Blaire E Barton, Matthew K Collins, Cindy H Chau, Hyoyoung Choo-Wosoba, David J Venzon, Christian Steinebach, Kathleen M Garchitorena, Bhruga Shah, Eric L Sarin, Michael Gütschow, William Douglas Figg
Preclinical Evaluation of a Novel Series of Polyfluorinated Thalidomide Analogs in Drug-Resistant Multiple Myeloma. Biomolecules 14 (6) (2024)
Aleša Bricelj, Yuen Lam Dora Ng, Martina Gobec, Robert Kuchta, Wanyi Hu, Špela Javornik, Miha Rožič, Michael Gütschow, Guangrong Zheng, Jan Krönke, Christian Steinebach, Gobec Izidor Sosič
Design, Synthesis, and Evaluation of BCL-2 Targeting PROTACs. Chemistry (Weinheim an der Bergstrasse, Germany) 30 (45) (2024)
Yuki Yamauchi, Sho Konno, Noriko Omura, Narumi Yoshioka, Alexandra Hingst, Michael Gütschow, Christa Elisabeth Müller, Akihiro Taguchi, Atsuhiko Taniguchi, Atsushi Kawaguchi, Yoshio Hayashi
Detection of Active SARS-CoV-2 3CL Protease in Infected Cells Using Activity-Based Probes with a 2,6-Dichlorobenzoyloxymethyl Ketone Reactive Warhead. ACS chemical biology 19 (5) (2024)
Yuki Yamauchi, Sho Konno, Noriko Omura, Narumi Yoshioka, Alexandra Hingst, Michael Gütschow, Christa Elisabeth Müller, Akihiro Taguchi, Atsuhiko Taniguchi, Atsushi Kawaguchi, Yoshio Hayashi
Detection of Active SARS-CoV-2 3CL Protease in Infected Cells Using Activity-Based Probes with a 2,6-Dichlorobenzoyloxymethyl Ketone Reactive Warhead. ACS chemical biology 19 (5) (2024)
Philipp Flury, Julian Breidenbach, Nadine Krüger, Rabea Voget, Laura Schäkel, Yaoyao Si, Vesa Krasniqi, Sara Calistri, Matthias Olfert, Katharina Sylvester, Cheila Rocha, Raphael Ditzinger, Alexander Rasch, Stefan Pöhlmann, Thales Kronenberger, Antti Poso, Katharina Rox, Stefan A Laufer, Christa Elisabeth Müller, Michael Gütschow, Thanigaimalai Pillaiyar
Cathepsin-Targeting SARS-CoV-2 Inhibitors: Design, Synthesis, and Biological Activity. ACS pharmacology & translational science 7 (2) (2024)
Philipp Flury, Julian Breidenbach, Nadine Krüger, Rabea Voget, Laura Schäkel, Yaoyao Si, Vesa Krasniqi, Sara Calistri, Matthias Olfert, Katharina Sylvester, Cheila Rocha, Raphael Ditzinger, Alexander Rasch, Stefan Pöhlmann, Thales Kronenberger, Antti Poso, Katharina Rox, Stefan A Laufer, Christa Elisabeth Müller, Michael Gütschow, Thanigaimalai Pillaiyar
Cathepsin-Targeting SARS-CoV-2 Inhibitors: Design, Synthesis, and Biological Activity. ACS pharmacology & translational science 7 (2) (2024)
Aleša Bricelj, Yuen Lam Dora Ng, Martina Gobec, Robert Kuchta, Wanyi Hu, Špela Javornik, Miha Rožič, Michael Gütschow, Guangrong Zheng, Jan Krönke, Christian Steinebach, Gobec Izidor Sosič
Design, Synthesis, and Evaluation of BCL-2 Targeting PROTACs. Chemistry (Weinheim an der Bergstrasse, Germany) (2024)
Christian Steinebach, Aleša Bricelj, Arunima Murgai, Gobec Izidor Sosič, Luca Bischof, Yuen Lam Dora Ng, Christopher Heim, Samuel Maiwald, Matic Proj, Rabea Voget, Felix Feller, Janez Košmrlj, Valeriia Sapozhnikova, Annika Schmidt, Maximilian Rudolf Zuleeg, Patricia Lemnitzer, Philipp Mertins, Finn K Hansen, Michael Gütschow, Jan Krönke, Marcus D Hartmann
Leveraging Ligand Affinity and Properties: Discovery of Novel Benzamide-Type Cereblon Binders for the Design of PROTACs. Journal of medicinal chemistry (2023)
Yuen Lam Dora Ng, Aleša Bricelj, Jacqueline A Jansen, Arunima Murgai, Kirsten Peter, Katherine Aleisha Donovan, Michael Gütschow, Jan Krönke, Christian Steinebach, Gobec Izidor Sosič
Heterobifunctional Ligase Recruiters Enable pan-Degradation of Inhibitor of Apoptosis Proteins. Journal of medicinal chemistry (2023)
Robert Kuchta, Christopher Heim, Alexander Herrmann, Samuel Maiwald, Yuen Lam Dora Ng, Gobec Izidor Sosič, Tim Keuler, Jan Krönke, Michael Gütschow, Marcus D Hartmann, Christian Steinebach
Accessing three-branched high-affinity cereblon ligands for molecular glue and protein degrader design. RSC chemical biology 4 (3) (2023)
Robert Kuchta, Christopher Heim, Alexander Herrmann, Samuel Maiwald, Yuen Lam Dora Ng, Gobec Izidor Sosič, Tim Keuler, Jan Krönke, Michael Gütschow, Marcus D Hartmann, Christian Steinebach
Accessing three-branched high-affinity cereblon ligands for molecular glue and protein degrader design. RSC chemical biology 4 (3) (2023)
Lan Phuong Vu, Claudia J Diehl, Ryan Casement, Adam G Bond, Christian Steinebach, Nika Strašek Benedik, Aleša Bricelj, Andrej Perdih, Gregor Schnakenburg, Gobec Izidor Sosič, Alessio Ciulli, Michael Gütschow
Expanding the Structural Diversity at the Phenylene Core of Ligands for the von Hippel-Lindau E3 Ubiquitin Ligase: Development of Highly Potent Hypoxia-Inducible Factor-1α Stabilizers. Journal of medicinal chemistry (2023)
Florian Pöstges, Kevin Kayser, Jan Appelhaus, Marius Monschke, Michael Gütschow, Christian Steinebach, Karl G Wagner
Solubility Enhanced Formulation Approaches to Overcome Oral Delivery Obstacles of PROTACs. Pharmaceutics 15 (1) (2023)
Stefan Josef Hammerschmidt, Hannah Maus, Annabelle Carolin Weldert, Michael Gütschow, Christian Kersten
Improving binding entropy by higher ligand symmetry? - A case study with human matriptase. RSC medicinal chemistry 14 (5) (2023)
Florian Pöstges, Kevin Kayser, Jan Appelhaus, Marius Monschke, Michael Gütschow, Christian Steinebach, Karl G Wagner
Solubility Enhanced Formulation Approaches to Overcome Oral Delivery Obstacles of PROTACs. Pharmaceutics 15 (1) (2023)
Florian Pöstges, Kevin Kayser, Jan Appelhaus, Marius Monschke, Michael Gütschow, Christian Steinebach, Karl G Wagner
Solubility Enhanced Formulation Approaches to Overcome Oral Delivery Obstacles of PROTACs. Pharmaceutics 15 (1) (2023)
Florian Pöstges, Kevin Kayser, Jan Appelhaus, Marius Monschke, Michael Gütschow, Christian Steinebach, Karl G Wagner
Solubility Enhanced Formulation Approaches to Overcome Oral Delivery Obstacles of PROTACs. Pharmaceutics 15 (1) (2023)
Nina Geiger, Viktoria Diesendorf, Valeria Roll, Eva-Maria König, Helena Obernolte, Katherina Sewald, Julian Breidenbach, Thanigaimalai Pillaiyar, Michael Gütschow, Christa Elisabeth Müller, Jochen Bodem
Cell Type-Specific Anti-Viral Effects of Novel SARS-CoV-2 Main Protease Inhibitors. International journal of molecular sciences 24 (4) (2023)
Nina Geiger, Viktoria Diesendorf, Valeria Roll, Eva-Maria König, Helena Obernolte, Katherina Sewald, Julian Breidenbach, Thanigaimalai Pillaiyar, Michael Gütschow, Christa Elisabeth Müller, Jochen Bodem
Cell Type-Specific Anti-Viral Effects of Novel SARS-CoV-2 Main Protease Inhibitors. International journal of molecular sciences 24 (4) (2023)
Nina Geiger, Viktoria Diesendorf, Valeria Roll, Eva-Maria König, Helena Obernolte, Katherina Sewald, Julian Breidenbach, Thanigaimalai Pillaiyar, Michael Gütschow, Christa Elisabeth Müller, Jochen Bodem
Cell Type-Specific Anti-Viral Effects of Novel SARS-CoV-2 Main Protease Inhibitors. International journal of molecular sciences 24 (4) (2023)
Paul W Elsinghorst, Timo Wille, Danijela Barić, Matthias D Mertens, Madlen Baumann, Jim Küppers, Michael Gütschow
Aminoalkoxy-substituted coumarins: Synthesis and evaluation for reactivation of inhibited human acetylcholinesterase. Archiv der Pharmazie 355 (11) (2022)
Thanigaimalai Pillaiyar, Philipp Flury, Nadine Krüger, Haixia Su, Laura Schäkel, Elany Barbosa da Silva, Olga Eppler, Thales Kronenberger, Tianqing Nie, Stephanie Luedtke, Cheila Rocha, Katharina Sylvester, Marvin R I Petry, James H McKerrow, Antti Poso, Stefan Pöhlmann, Michael Gütschow, Anthony J O'Donoghue, Yechun Xu, Christa Elisabeth Müller, Stefan A Laufer
Small-Molecule Thioesters as SARS-CoV-2 Main Protease Inhibitors: Enzyme Inhibition, Structure-Activity Relationships, Antiviral Activity, and X-ray Structure Determination. Journal of medicinal chemistry 65 (13) (2022)
Bianca Schulte, Maria König, Beate I Escher, Sophie Wittenburg, Matic Proj, Valentina Wolf, Carina Lemke, Gregor Schnakenburg, Gobec Izidor Sosič, Hendrik Streeck, Christa Elisabeth Müller, Michael Gütschow, Christian Steinebach
Andrographolide Derivatives Target the KEAP1/NRF2 Axis and Possess Potent Anti-SARS-CoV-2 Activity. ChemMedChem 17 (5) (2022)
Lukas M Gockel, Vladlena Pfeifer, Fabian Baltes, Rafael D Bachmaier, Karl G Wagner, Gerd Bendas, Michael Gütschow, Izidor Sosič, Christian Steinebach
Design, synthesis, and characterization of PROTACs targeting the androgen receptor in prostate and lung cancer models. Archiv der Pharmazie 355 (5) (2022)
Shenghua Gao, Letian Song, Tobias Claff, Molly Woodson, Katharina Sylvester, Lanlan Jing, Renato H Weiße, Yusen Cheng, Norbert Sträter, Laura Schäkel, Michael Gütschow, Bing Ye, Mianling Yang, Tao Zhang, Dongwei Kang, Karoly Toth, John E Tavis, Ann E Tollefson, Christa Elisabeth Müller, Peng Zhan, Xinyong Liu
Discovery and Crystallographic Studies of Nonpeptidic Piperazine Derivatives as Covalent SARS-CoV-2 Main Protease Inhibitors. Journal of medicinal chemistry (2022)
Tim Keuler, Carina Lemke, Paul W Elsinghorst, Isabel Iriepa, Mourad Chioua, María Angeles Martínez-Grau, Christopher D Beadle, Tatiana Vetman, Francisco López-Muñoz, Timo Wille, Ulrike Bartz, Winnie Deuther-Conrad, José Marco-Contelles, Michael Gütschow
The Chemotype of Chromanones as a Privileged Scaffold for Multineurotarget Anti-Alzheimer Agents. ACS pharmacology & translational science 5 (11) (2022)
Arunima Murgai, Gobec Izidor Sosič, Martina Gobec, Patricia Lemnitzer, Matic Proj, Sophie Wittenburg, Rabea Voget, Michael Gütschow, Jan Krönke, Christian Steinebach
Targeting the deubiquitinase USP7 for degradation with PROTACs. Chemical communications (Cambridge, England) 58 (63) (2022)
Carina Lemke, Adéla Jílková, Dominic Ferber, Annett Braune, Anja On, Patrick Johe, Alena Zíková, Tanja Schirmeister, Michael Mareš, Martin Horn, Michael Gütschow
Two Tags in One Probe: Combining Fluorescence- and Biotin-based Detection of the Trypanosomal Cysteine Protease Rhodesain. Chemistry (Weinheim an der Bergstrasse, Germany) 28 (62) (2022)
Anna K Krome, Tim Becker, Stefan Kehraus, Andrea Schiefer, Michael Gütschow, Lillibeth Chaverra-Muñoz, Stephan Hüttel, Rolf Jansen, Marc Stadler, Alexandra Ehrens, Domen Pogorevc, Daniel Krug, Marc P Hübner, Thomas Hesterkamp, Kenneth M Pfarr, Achim Hoerauf, Karl G Wagner, Gabriele M König
Corallopyronin A: antimicrobial discovery to preclinical development. Natural product reports 39 (9) (2022)
Tim Keuler, Dominic Ferber, Michael Marleaux, Matthias Geyer, Michael Gütschow
Structure-Stability Relationship of NLRP3 Inflammasome-Inhibiting Sulfonylureas. ACS omega 7 (9) (2022)
Daniel S J Miller, Sabine A Voell, Gobec Izidor Sosič, Matic Proj, Olivia W Rossanese, Gregor Schnakenburg, Michael Gütschow, Ian Collins, Christian Steinebach
Encoding BRAF inhibitor functions in protein degraders. RSC medicinal chemistry 13 (6) (2022)
Tim Keuler, Beate König, Nico Bückreiß, Fabian B Kraft, Philipp König, Linda Schäker-Hübner, Christian Steinebach, Gerd Bendas, Michael Gütschow, Finn K Hansen
Development of the first non-hydroxamate selective HDAC6 degraders. Chemical communications (Cambridge, England) 58 (79) (2022)
Shenghua Gao, Katharina Sylvester, Letian Song, Tobias Claff, Lanlan Jing, Molly Woodson, Renato H Weiße, Yusen Cheng, Laura Schäkel, Marvin Petry, Michael Gütschow, Anke C Schiedel, Norbert Sträter, Dongwei Kang, Shujing Xu, Karoly Toth, John E Tavis, Ann E Tollefson, Christa Elisabeth Müller, Xinyong Liu, Peng Zhan
Discovery and Crystallographic Studies of Trisubstituted Piperazine Derivatives as Non-Covalent SARS-CoV-2 Main Protease Inhibitors with High Target Specificity and Low Toxicity. Journal of medicinal chemistry 65 (19) (2022)
Sho Konno, Kiyotaka Kobayashi, Miki Senda, Yuta Funai, Yuta Seki, Ikumi Tamai, Laura Schäkel, Kyousuke Sakata, Thanigaimalai Pillaiyar, Akihiro Taguchi, Atsuhiko Taniguchi, Michael Gütschow, Christa Elisabeth Müller, Koh Takeuchi, Mikako Hirohama, Atsushi Kawaguchi, Masaki Kojima, Toshiya Senda, Yoshiyuki Shirasaka, Wataru Kamitani, Yoshio Hayashi
3CL Protease Inhibitors with an Electrophilic Arylketone Moiety as Anti-SARS-CoV-2 Agents. Journal of medicinal chemistry (2021)
Christa Elisabeth Müller, Finn K Hansen, Michael Gütschow, Dennis C Liotta, Courtney C Aldrich
New Drug Modalities in Medicinal Chemistry, Pharmacology, and Translational Science: Joint Virtual Special Issue by Journal of Medicinal Chemistry , ACS Medicinal Chemistry Letters , and ACS Pharmacology & Translational Science . ACS pharmacology & translational science 4 (6) (2021)
Winnie Deuther-Conrad, Daniel Diez-Iriepa, Isabel Iriepa, Francisco López-Muñoz, María Angeles Martínez-Grau, Michael Gütschow, José Marco-Contelles
Studies on the affinity of 6-[(n-(cyclo)aminoalkyl)oxy]-4H-chromen-4-ones for sigma 1/2 receptors. RSC medicinal chemistry 12 (6) (2021)
Lan Phuong Vu, Michael Gütschow
Diketomorpholines: Synthetic Accessibility and Utilization. ACS omega 7 (1) (2021)
Christa Elisabeth Müller, Finn K Hansen, Michael Gütschow, Dennis C Liotta, Courtney C Aldrich
New Drug Modalities in Medicinal Chemistry, Pharmacology, and Translational Science: Joint Virtual Special Issue by Journal of Medicinal Chemistry, ACS Medicinal Chemistry Letters, and ACS Pharmacology & Translational Science. Journal of medicinal chemistry 64 (19) (2021)
Izidor Sosič, Martina Gobec, Christian Steinebach, Martin Schlesinger, Gerd Bendas, Michael Gütschow
Another structural correction for 1-oxo-1H-phenalene-2,3-dicarbonitriles: Synthesis of a potent BCL-2 inhibiting 7-phenoxy derivative. Archiv der Pharmazie 354 (10) (2021)
Carina Lemke, Jakub Benýšek, Dominik Brajtenbach, Christian Breuer, Adéla Jílková, Martin Horn, Michal Buša, Lenka Ulrychová, Annika Illies, Katharina F Kubatzky, Ulrike Bartz, Michael Mareš, Michael Gütschow
An Activity-Based Probe for Cathepsin K Imaging with Excellent Potency and Selectivity. Journal of medicinal chemistry 64 (18) (2021)
Julian Breidenbach, Carina Lemke, Thanigaimalai Pillaiyar, Laura Schäkel, Ghazl Al Hamwi, Miriam Diett, Robin Gedschold, Nina Geiger, Vittoria Lopez, Salahuddin Mirza, Vigneshwaran Namasivayam, Anke C Schiedel, Katharina Sylvester, Dominik Thimm, Christin Vielmuth, Lan Phuong Vu, Maria Zyulina, Jochen Bodem, Michael Gütschow, Christa Elisabeth Müller
Targeting the Main Protease of SARS-CoV-2: From the Establishment of High Throughput Screening to the Design of Tailored Inhibitors. Angewandte Chemie (International ed. in English) 60 (18) (2021)
Aleša Bricelj, Yuen Lam Dora Ng, Dominic Ferber, Robert Kuchta, Sina Müller, Marius Monschke, Karl G Wagner, Jan Krönke, Gobec Izidor Sosič, Michael Gütschow, Christian Steinebach
Influence of Linker Attachment Points on the Stability and Neosubstrate Degradation of Cereblon Ligands. ACS medicinal chemistry letters 12 (11) (2021)
Laura Schäkel, Salahuddin Mirza, Markus Pietsch, Sang-Yong Lee, Tim Keuler, Katharina Sylvester, Julie Pelletier, Jean Sévigny, Thanigaimalai Pillaiyar, Vigneshwaran Namasivayam, Michael Gütschow, Christa Elisabeth Müller
2-Substituted thienotetrahydropyridine derivatives: Allosteric ectonucleotidase inhibitors. Archiv der Pharmazie 354 (12) (2021)
Christa Elisabeth Müller, Finn K Hansen, Michael Gütschow, Dennis C Liotta, Courtney C Aldrich
New Drug Modalities in Medicinal Chemistry, Pharmacology, and Translational Science: Joint Virtual Special Issue by Journal of Medicinal Chemistry, ACS Medicinal Chemistry Letters, and ACS Pharmacology & Translational Science. ACS medicinal chemistry letters 12 (10) (2021)
Christian Steinebach, Yuen Lam Dora Ng, Gobec Izidor Sosič, Chih-Shia Lee, Sirui Chen, Stefanie Lindner, Lan Phuong Vu, Aleša Bricelj, Reza Haschemi, Marius Monschke, Elisabeth Steinwarz, Karl G Wagner, Gerd Bendas, Ji Luo, Michael Gütschow, Jan Krönke
Systematic exploration of different E3 ubiquitin ligases: an approach towards potent and selective CDK6 degraders. Chemical science 11 (13) (2020)
Lorenzo Cianni, Carina Lemke, Erik Gilberg, Christian Feldmann, Fabiana Rosini, Fernanda Dos Reis Rocho, Jean F R Ribeiro, Daiane Y Tezuka, Carla D Lopes, Sérgio de Albuquerque, Jürgen Bajorath, Stefan Laufer, Andrei Leitão, Michael Gütschow, Carlos Alberto Montanari
Mapping the S1 and S1' subsites of cysteine proteases with new dipeptidyl nitrile inhibitors as trypanocidal agents. PLoS neglected tropical diseases 14 (3) (2020)
Solenne Rivière, Christin Vielmuth, Christiane Ennenbach, Aliaa Abdelrahman, Carina Lemke, Michael Gütschow, Christa Elisabeth Müller, Dirk Menche
Design, Synthesis and Biological Evaluation of Highly Potent Simplified Archazolids. ChemMedChem 15 (14) (2020)
Markus Kuschak, Vigneshwaran Namasivayam, Muhammad Rafehi, Jan Hendrik Voß, Jaspal Garg, Jonathan G Schlegel, Aliaa Abdelrahman, Stefan Kehraus, Raphael Reher, Jim Küppers, Katharina Sylvester, Sonja Hinz, Michaela Matthey, Daniela Wenzel, Bernd K Fleischmann, Alexander Pfeifer, Asuka Inoue, Michael Gütschow, Gabriele M König, Christa Elisabeth Müller
Cell-permeable high-affinity tracers for Gq proteins provide structural insights, reveal distinct binding kinetics and identify small molecule inhibitors. British journal of pharmacology 177 (8) (2020)
Stephan Scheeff, Solenne Rivière, Johal Ruiz, Aliaa Abdelrahman, Anna-Christina Schulz-Fincke, Meryem Köse, Felix Tiburcy, Helmut Wieczorek, Michael Gütschow, Christa Elisabeth Müller, Dirk Menche
Synthesis of Novel Potent Archazolids: Pharmacology of an Emerging Class of Anticancer Drugs. Journal of medicinal chemistry 63 (4) (2020)
Norbert Kirchner, Carolina Cano-Prieto, Anna-Christina Schulz-Fincke, Michael Gütschow, Nico Ortlieb, Julia Moschny, Timo Horst Johannes Niedermeyer, Jeannie Horak, Michael Lämmerhofer, Menno van der Voort, Jos M Raaijmakers, Harald Gross
Discovery of Thanafactin A, a Linear, Proline-Containing Octalipopeptide from Pseudomonas sp. SH-C52, Motivated by Genome Mining. Journal of natural products 84 (1) (2020)
Michael Mareš, Martin Horn, Jindřich Fanfrlík, Jim Küppers, Petr Pachl, Pavlína Řezáčová, Martin Lepsik, Pavla Fajtová, Petra Rubešová, Marta Chanová, Conor R Caffrey, Michael Gütschow, Michael Mareš
Azanitrile Inhibitors of the SmCB1 Protease Target Are Lethal to Schistosoma mansoni: Structural and Mechanistic Insights into Chemotype Reactivity. ACS infectious diseases 7 (1) (2020)
Megan L Peach, Shaunna L Beedie, Cindy H Chau, Matthew K Collins, Suzana Markolovic, Weiming Luo, David Tweedie, Christian Steinebach, Nigel H Greig, Michael Gütschow, Neil Vargesson, Marc C Nicklaus, William Douglas Figg
Antiangiogenic Activity and in Silico Cereblon Binding Analysis of Novel Thalidomide Analogs. Molecules (Basel, Switzerland) 25 (23) (2020)
Anna K Krome, Tim Becker, Stefan Kehraus, Andrea Schiefer, Christian Steinebach, Tilman Aden, Stefan J Frohberger, Álvaro López Mármol, Dnyaneshwar Kapote, Rolf Jansen, Lillibeth Chaverra-Muñoz, Marc P Hübner, Kenneth M Pfarr, Thomas Hesterkamp, Marc Stadler, Michael Gütschow, Gabriele M König, Achim Hoerauf, Karl G Wagner
Solubility and Stability Enhanced Oral Formulations for the Anti-Infective Corallopyronin A. Pharmaceutics 12 (11) (2020)
Jim Küppers, Tobias Benkel, Suvi Annala, Kenichi Kimura, Lisa Reinelt, Bernd K Fleischmann, Evi Kostenis, Michael Gütschow
Tetrahydroimidazo[1,2-a]pyrazine Derivatives: Synthesis and Evaluation as Gαq -Protein Ligands. Chemistry (Weinheim an der Bergstrasse, Germany) 26 (55) (2020)
Jim Küppers, Tobias Benkel, Suvi Annala, Gregor Schnakenburg, Evi Kostenis, Michael Gütschow
BIM-46174 fragments as potential ligands of G proteins. MedChemComm 10 (10) (2019)
Jean Jacques Vanden Eynde, Arduino Aleksander Mangoni, Jarkko Rautio, Jérôme Leprince, Yasu-Taka Azuma, Alfonso T García-Sosa, Christopher Hulme, Josef Jampilek, Rafik Karaman, Wei Li, Paula A C Gomes, Dimitra Hadjipavlou-Litina, Raffaele Capasso, Athina Geronikaki, Gennaro Chiappetta, Jean Marc Sabatier, Rino Ragno, Tiziano Tuccinardi, Andrea Trabocchi, Jean-Yves Winum, Francisco Javier Luque, Katalin Prokai-Tatrai, Mariana Spetea, Michael Gütschow, Ivan Kosalec, Catherine Guillou, Maria Helena Vasconcelos, George Kokotos, Giulio Rastelli, Maria Emília Sousa, Clementina Manera, Sandra Gemma, Stefano Mangani, Carlo Siciliano, Stefania Galdieroa, Hong Liu, Peter J H Scott, Cristóbal de Los Ríos, Luigi A Agrofoglio, Simona Collina, Rita C Guedes, Diego Muñoz-Torrero
Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-6. Molecules (Basel, Switzerland) 25 (1) (2019)
Christian Steinebach, Gobec Izidor Sosič, Stefanie Lindner, Aleša Bricelj, Franziska Kohl, Yuen Lam Dora Ng, Marius Monschke, Karl G Wagner, Jan Krönke, Michael Gütschow
A MedChem toolbox for cereblon-directed PROTACs. MedChemComm 10 (6) (2019)
Lorenzo Cianni, Christian Wolfgang Feldmann, Erik Gilberg, Michael Gütschow, Luiz Juliano, Andrei Leitão, Jürgen Bajorath, Carlos Alberto Montanari
Can Cysteine Protease Cross-Class Inhibitors Achieve Selectivity? Journal of medicinal chemistry 62 (23) (2019)
Arduino Aleksander Mangoni, Jean Jacques Vanden Eynde, Josef Jampilek, Dimitra Hadjipavlou-Litina, Hong Liu, Jóhannes Reynisson, Maria Emília Sousa, Paula A C Gomes, Katalin Prokai-Tatrai, Tiziano Tuccinardi, Jean Marc Sabatier, Francisco Javier Luque, Jarkko Rautio, Rafik Karaman, Maria Helena Vasconcelos, Sandra Gemma, Stefania Galdieroa, Christopher Hulme, Simona Collina, Michael Gütschow, George Kokotos, Carlo Siciliano, Raffaele Capasso, Luigi A Agrofoglio, Rino Ragno, Diego Muñoz-Torrero
Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-5. Molecules (Basel, Switzerland) 24 (13) (2019)
Arduino Aleksander Mangoni, Tiziano Tuccinardi, Simona Collina, Jean Jacques Vanden Eynde, Diego Muñoz-Torrero, Rafik Karaman, Carlo Siciliano, Maria Emília Sousa, Katalin Prokai-Tatrai, Jarkko Rautio, Catherine Guillou, Michael Gütschow, Stefania Galdieroa, Hong Liu, Luigi A Agrofoglio, Jean Marc Sabatier, Christopher Hulme, George Kokotos, Qi-Dong You, Paula A C Gomes
Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-3. Molecules (Basel, Switzerland) 23 (7) (2018)
Arduino Aleksander Mangoni, Catherine Guillou, Jean Jacques Vanden Eynde, Christopher Hulme, Josef Jampilek, Wei Li, Katalin Prokai-Tatrai, Jarkko Rautio, Simona Collina, Tiziano Tuccinardi, Maria Emília Sousa, Jean Marc Sabatier, Stefania Galdieroa, Rafik Karaman, George Kokotos, Giangiacomo Torri, Francisco Javier Luque, Maria Helena Vasconcelos, Dimitra Hadjipavlou-Litina, Carlo Siciliano, Michael Gütschow, Rino Ragno, Paula A C Gomes, Luigi A Agrofoglio, Diego Muñoz-Torrero
Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes⁻4. Molecules (Basel, Switzerland) 24 (1) (2018)
Anna-Christina Schulz-Fincke, Alexander S Tikhomirov, Annett Braune, Tamara Girbl, Erik Gilberg, Jürgen Bajorath, Michael Blaut, Sussan Nourshargh, Michael Gütschow
Design of an Activity-Based Probe for Human Neutrophil Elastase: Implementation of the Lossen Rearrangement To Induce Förster Resonance Energy Transfers. Biochemistry 57 (5) (2018)
Christian Steinebach, Stefanie Lindner, Namrata D Udeshi, Deepak C Mani, Hannes Kehm, Simon Köpff, Steven A Carr, Michael Gütschow, Jan Krönke
Homo-PROTACs for the Chemical Knockdown of Cereblon. ACS chemical biology 13 (9) (2018)
Erik Gilberg, Michael Gütschow, Jürgen Bajorath
X-ray Structures of Target-Ligand Complexes Containing Compounds with Assay Interference Potential. Journal of medicinal chemistry 61 (3) (2018)
Martin Mangold, Michael Gütschow, Marit Stirnberg
A Short Peptide Inhibitor as an Activity-Based Probe for Matriptase-2. Pharmaceuticals (Basel, Switzerland) 11 (2) (2018)
Christian Steinebach, Agnieszka Ambrożak, Stefan Dosa, Shaunna L Beedie, Jonathan D Strope, Gregor Schnakenburg, William D Figg, Michael Gütschow
Synthesis, Structural Characterization, and Antiangiogenic Activity of Polyfluorinated Benzamides. ChemMedChem 13 (19) (2018)

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Michael Gütschow