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Luc Brunsveld (L Brunsveld)

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Publication Activity (10 Years)

Years Active: 2016-2023
Publications (10 Years): 57

Top Venues

Journal of the American Chemical Society

Angewandte Chemie (International ed. in English)

Chemical science

Journal of medicinal chemistry

TU Eindhoven

This page only lists publications with an associated author ORCID identifier.

Affiliation History

TU Eindhoven

Netherlands

Professor of Chemical Biology :: Department of Biomedical Engineering

Publications

Carlo J A Verhoef, Danielle F Kay, Lars van Dijck, Richard G Doveston, Luc Brunsveld, Aneika C Leney, Peter J Cossar
Tracking the mechanism of covalent molecular glue stabilization using native mass spectrometry. Chemical science 14 (24) (2023)
Bente A Somsen, Rick J C Schellekens, Carlo J A Verhoef, Michelle R Arkin, Christian Ottmann, Peter J Cossar, Luc Brunsveld
Reversible Dual-Covalent Molecular Locking of the 14-3-3/ERRγ Protein-Protein Interaction as a Molecular Glue Drug Discovery Approach. Journal of the American Chemical Society (2023)
Dyana N Kenanova, Emira J Visser, Johanna M Virta, Eline Sijbesma, Federica Centorrino, Holly R Vickery, Mengqi Zhong, R Jeffrey Neitz, Luc Brunsveld, Christian Ottmann, Michelle R Arkin
A Systematic Approach to the Discovery of Protein-Protein Interaction Stabilizers. ACS central science 9 (5) (2023)
Markella Konstantinidou, Emira J Visser, Edmee Vandenboorn, Sheng Chen, Priyadarshini Jaishankar, Maurits Overmans, Shubhankar Dutta, R Jeffrey Neitz, Adam R Renslo, Christian Ottmann, Luc Brunsveld, Michelle R Arkin
Structure-Based Optimization of Covalent, Small-Molecule Stabilizers of the 14-3-3σ/ERα Protein-Protein Interaction from Nonselective Fragments. Journal of the American Chemical Society (2023)
Nick H J Geertjens, Pim J de Vink, Tim Wezeman, Albert J Markvoort, Luc Brunsveld
Straightforward model construction and analysis of multicomponent biomolecular systems in equilibrium. RSC chemical biology 4 (4) (2023)
Arjan Hazegh Nikroo, Lenne J M Lemmens, Tim Wezeman, Christian Ottmann, Maarten Merkx, Luc Brunsveld
Switchable Control of Scaffold Protein Activity via Engineered Phosphoregulated Autoinhibition. ACS synthetic biology 11 (7) (2022)
Pim J de Vink, Auke A Koops, Giulia D'Arrigo, Gabriele Cruciani, Francesca Spyrakis, Luc Brunsveld
Cooperativity as quantification and optimization paradigm for nuclear receptor modulators. Chemical science 13 (9) (2022)
Loes M Stevers, Madita Wolter, Graeme W Carlile, Dwight Macdonald, Luc Richard, Frank Gielkens, John W Hanrahan, David Y Thomas, Sai Kumar Chakka, Mark L Peterson, Helmut Thomas, Luc Brunsveld, Christian Ottmann
Macrocycle-stabilization of its interaction with 14-3-3 increases plasma membrane localization and activity of CFTR. Nature communications 13 (1) (2022)
Tsuyoshi Mashima, Marleen H M E van Stevendaal, Femke R A Cornelissens, Alexander Francesco Mason, Bas J H M Rosier, Wiggert J Altenburg, Koji Oohora, Shota Hirayama, Takashi Hayashi, Jan C M Van Hest, Luc Brunsveld
DNA-Mediated Protein Shuttling between Coacervate-Based Artificial Cells. Angewandte Chemie (International ed. in English) 61 (17) (2022)
Govind P Maurya, Deepak Verma, Aloka Sinha, Luc Brunsveld, V Haridas
Hydrophobicity Directed Chiral Self-Assembly and Aggregation-Induced Emission: Diacetylene-Cored Pseudopeptide Chiral Dopants. Angewandte Chemie (International ed. in English) 61 (42) (2022)
Bente A Somsen, Fenna W B Craenmehr, Wei-Hong W Liu, Auke A Koops, Marloes A M Pennings, Emira J Visser, Christian Ottmann, Peter J Cossar, Luc Brunsveld
Functional mapping of the 14-3-3 hub protein as a guide to design 14-3-3 molecular glues. Chemical science 13 (44) (2022)
Tsuyoshi Mashima, Bas J H M Rosier, Koji Oohora, Tom F A de Greef, Takashi Hayashi, Luc Brunsveld
Dynamic Protease Activation on a Multimeric Synthetic Protein Scaffold via Adaptable DNA-Based Recruitment Domains. Angewandte Chemie (International ed. in English) 60 (20) (2021)
Pim J de Vink, Tim van der Hek, Luc Brunsveld
Light-driven release of cucurbit[8]uril from a bivalent cage. Chemical science 12 (19) (2021)
Rens M J M de Vries, Femke A Meijer, Richard G Doveston, Iris A Leijten-van de Gevel, Luc Brunsveld
Cooperativity between the orthosteric and allosteric ligand binding sites of RORγt. Proceedings of the National Academy of Sciences of the United States of America 118 (6) (2021)
Xavier Guillory, Inesa Hadrović, Pim J de Vink, Andrea Sowislok, Luc Brunsveld, Thomas Schrader, Christian Ottmann
Supramolecular Enhancement of a Natural 14-3-3 Protein Ligand. Journal of the American Chemical Society 143 (34) (2021)
Eline Sijbesma, Kenneth K Hallenbeck, Sebastian A Andrei, Reanne R Rust, Joris M C Adriaans, Luc Brunsveld, Michelle R Arkin, Christian Ottmann
Exploration of a 14-3-3 PPI Pocket by Covalent Fragments as Stabilizers. ACS medicinal chemistry letters 12 (6) (2021)
Femke A Meijer, Guido J M Oerlemans, Luc Brunsveld
Orthosteric and Allosteric Dual Targeting of the Nuclear Receptor RORγt with a Bitopic Ligand. ACS chemical biology 16 (3) (2021)
Peter J Cossar, Madita Wolter, Lars van Dijck, Dario Valenti, Laura M Levy, Christian Ottmann, Luc Brunsveld
Reversible Covalent Imine-Tethering for Selective Stabilization of 14-3-3 Hub Protein Interactions. Journal of the American Chemical Society 143 (22) (2021)
Madita Wolter, Dario Valenti, Peter J Cossar, Stanimira Hristeva, Laura M Levy, Thorsten Genski, Torsten Hoffmann, Luc Brunsveld, Dimitrios Tzalis, Christian Ottmann
An Exploration of Chemical Properties Required for Cooperative Stabilization of the 14-3-3 Interaction with NF-κB-Utilizing a Reversible Covalent Tethering Approach. Journal of medicinal chemistry 64 (12) (2021)
Jurgen Schill, Bas J H M Rosier, Berta Gumí Audenis, Eva Magdalena Estirado, Tom F A de Greef, Luc Brunsveld
Assembly of Dynamic Supramolecular Polymers on a DNA Origami Platform. Angewandte Chemie (International ed. in English) 60 (14) (2021)
Femke A Meijer, Annet O W M Saris, Richard G Doveston, Guido J M Oerlemans, Rens M J M de Vries, Bente A Somsen, Anke Unger, Bert Klebl, Christian Ottmann, Peter J Cossar, Luc Brunsveld
Structure-Activity Relationship Studies of Trisubstituted Isoxazoles as Selective Allosteric Ligands for the Retinoic-Acid-Receptor-Related Orphan Receptor γt. Journal of medicinal chemistry 64 (13) (2021)
Eva Magdalena Estirado, Bas J H M Rosier, Tom F A de Greef, Luc Brunsveld
Dynamic modulation of proximity-induced enzyme activity using supramolecular polymers. Chemical communications (Cambridge, England) 56 (43) (2021)
Xiaolu Xu, Lenne J M Lemmens, Anniek den Hamer, Maarten Merkx, Christian Ottmann, Luc Brunsveld
Modular bioengineered kinase sensors via scaffold protein-mediated split-luciferase complementation. Chemical science 11 (21) (2020)
Eva Magdalena Estirado, Alexander Francesco Mason, Miguel Ángel Alemán García, Jan C M Van Hest, Luc Brunsveld
Supramolecular Nanoscaffolds within Cytomimetic Protocells as Signal Localization Hubs. Journal of the American Chemical Society 142 (20) (2020)
Karolien De Bosscher, Sofie J Desmet, Dorien Clarisse, Eva Estébanez-Perpiña, Luc Brunsveld
Nuclear receptor crosstalk - defining the mechanisms for therapeutic innovation. Nature reviews. Endocrinology 16 (7) (2020)
J Schill, Lucia Ferrazzano, Alessandra Tolomelli, Albertus P H J Schenning, Luc Brunsveld
Fluorene benzothiadiazole co-oligomer based aqueous self-assembled nanoparticles. RSC advances 10 (1) (2020)
Madita Wolter, Pim J de Vink, João Filipe Neves, Sonja Srdanović, Yusuke Higuchi, Nobuo Kato, Andrew J Wilson, Isabelle Landrieu, Luc Brunsveld, Christian Ottmann
Selectivity via Cooperativity: Preferential Stabilization of the p65/14-3-3 Interaction with Semisynthetic Natural Products. Journal of the American Chemical Society 142 (27) (2020)
Rens M J M de Vries, Richard G Doveston, Femke A Meijer, Luc Brunsveld
Elucidation of an Allosteric Mode of Action for a Thienopyrazole RORγt Inverse Agonist. ChemMedChem 15 (7) (2020)
Lenne J M Lemmens, Job A L Roodhuizen, Tom F A de Greef, Albert J Markvoort, Luc Brunsveld
Designed Asymmetric Protein Assembly on a Symmetric Scaffold. Angewandte Chemie (International ed. in English) 59 (29) (2020)
Lenne J M Lemmens, Christian Ottmann, Luc Brunsveld
Conjugated Protein Domains as Engineered Scaffold Proteins. Bioconjugate chemistry 31 (6) (2020)
Eline Sijbesma, Bente A Somsen, Galen P Miley, Iris A Leijten-van de Gevel, Luc Brunsveld, Michelle R Arkin, Christian Ottmann
Fluorescence Anisotropy-Based Tethering for Discovery of Protein-Protein Interaction Stabilizers. ACS chemical biology 15 (12) (2020)
Xavier Guillory, Madita Wolter, Seppe Leysen, João Filipe Neves, Ave Kuusk, Sylvia Genet, Bente Somsen, John Kenneth Morrow, Emma Rivers, Lotte van Beek, Joe Patel, Robert Goodnow, Heike Schoenherr, Nathan Fuller, Qing Cao, Richard G Doveston, Luc Brunsveld, Michelle R Arkin, Paola Castaldi, Helen Boyd, Isabelle Landrieu, Hongming Chen, Christian Ottmann
Fragment-based Differential Targeting of PPI Stabilizer Interfaces. Journal of medicinal chemistry 63 (13) (2020)
Eline Sijbesma, Emira Visser, Kathrin Plitzko, Philipp Thiel, Lech-Gustav Milroy, Markus Kaiser, Luc Brunsveld, Christian Ottmann
Structure-based evolution of a promiscuous inhibitor to a selective stabilizer of protein-protein interactions. Nature communications 11 (1) (2020)
Eva Magdalena Estirado, Miguel Angel Aleman Garcia, Jurgen Schill, Luc Brunsveld
Multivalent Ultrasensitive Interfacing of Supramolecular 1D Nanoplatforms. Journal of the American Chemical Society 141 (45) (2019)
Arthur H A M van Onzen, Raffaella Rossin, Albertus P H J Schenning, Klaas Nicolay, Lech-Gustav Milroy, Marc S Robillard, Luc Brunsveld
Tetrazine- trans-Cyclooctene Chemistry Applied to Fabricate Self-Assembled Fluorescent and Radioactive Nanoparticles for in Vivo Dual Mode Imaging. Bioconjugate chemistry 30 (3) (2019)
Pim J de Vink, Sebastian A Andrei, Yusuke Higuchi, Christian Ottmann, Lech-Gustav Milroy, Luc Brunsveld
Cooperativity basis for small-molecule stabilization of protein-protein interactions. Chemical science 10 (10) (2019)
Femke A Meijer, Richard G Doveston, Rens M J M de Vries, Gaël M Vos, Alex A A Vos, Seppe Leysen, Marcel Scheepstra, Christian Ottmann, Lech-Gustav Milroy, Luc Brunsveld
Ligand-Based Design of Allosteric Retinoic Acid Receptor-Related Orphan Receptor γt (RORγt) Inverse Agonists. Journal of medicinal chemistry 63 (1) (2019)
Eline Sijbesma, Kenneth K Hallenbeck, Seppe Leysen, Pim J de Vink, Lukasz Skóra, Wolfgang Jahnke, Luc Brunsveld, Michelle R Arkin, Christian Ottmann
Site-Directed Fragment-Based Screening for the Discovery of Protein-Protein Interaction Stabilizers. Journal of the American Chemical Society 141 (8) (2019)
Jurgen Schill, Sam van Dun, Maarten J Pouderoijen, Henk M Janssen, Lech-Gustav Milroy, Albertus P H J Schenning, Luc Brunsveld
Synthesis and Self-Assembly of Bay-Substituted Perylene Diimide Gemini-Type Surfactants as Off-On Fluorescent Probes for Lipid Bilayers. Chemistry (Weinheim an der Bergstrasse, Germany) 24 (30) (2018)
Sebastian A Andrei, Pim J de Vink, Eline Sijbesma, Ling Han, Luc Brunsveld, Nobuo Kato, Christian Ottmann, Yusuke Higuchi
Rationally Designed Semisynthetic Natural Product Analogues for Stabilization of 14-3-3 Protein-Protein Interactions. Angewandte Chemie (International ed. in English) 57 (41) (2018)
Sebastian A Andrei, Femke A Meijer, João Filipe Neves, Luc Brunsveld, Isabelle Landrieu, Christian Ottmann, Lech-Gustav Milroy
Inhibition of 14-3-3/Tau by Hybrid Small-Molecule Peptides Operating via Two Different Binding Modes. ACS chemical neuroscience 9 (11) (2018)
Dung T Dang, Arthur H A M van Onzen, Yvonne L Dorland, Luc Brunsveld
Cucurbit[8]uril Reactivation of an Inactivated Caspase-8 Mutant Reveals Differentiated Enzymatic Substrate Processing. Chembiochem : a European journal of chemical biology 19 (23) (2018)
Loes M Stevers, Pim J de Vink, Christian Ottmann, Jurriaan Huskens, Luc Brunsveld
A Thermodynamic Model for Multivalency in 14-3-3 Protein-Protein Interactions. Journal of the American Chemical Society 140 (43) (2018)
Stijn J A Aper, Anniek den Hamer, Simone F A Wouters, Lenne J M Lemmens, Christian Ottmann, Luc Brunsveld, Maarten Merkx
Protease-Activatable Scaffold Proteins as Versatile Molecular Hubs in Synthetic Signaling Networks. ACS synthetic biology 7 (9) (2018)
Miguel Ángel Alemán García, Eva Magdalena Estirado, Lech-Gustav Milroy, Luc Brunsveld
Dual-Input Regulation and Positional Control in Hybrid Oligonucleotide/Discotic Supramolecular Wires. Angewandte Chemie (International ed. in English) 57 (18) (2018)
Sam van Dun, Jurgen Schill, Lech-Gustav Milroy, Luc Brunsveld
Mutually Exclusive Cellular Uptake of Combinatorial Supramolecular Copolymers. Chemistry (Weinheim an der Bergstrasse, Germany) 24 (61) (2018)
Jurgen Schill, Lech-Gustav Milroy, Jody A M Lugger, Albertus P H J Schenning, Luc Brunsveld
Relationship between Side-Chain Polarity and the Self-Assembly Characteristics of Perylene Diimide Derivatives in Aqueous Solution. ChemistryOpen 6 (2) (2017)
Michael H Sonntag, Jurgen Schill, Luc Brunsveld
Integrin-Targeting Fluorescent Proteins: Exploration of RGD Insertion Sites. Chembiochem : a European journal of chemical biology 18 (5) (2017)
Sam van Dun, Christian Ottmann, Lech-Gustav Milroy, Luc Brunsveld
Supramolecular Chemistry Targeting Proteins. Journal of the American Chemical Society 139 (40) (2017)
Pim J de Vink, Jeroen M Briels, Thomas Schrader, Lech-Gustav Milroy, Luc Brunsveld, Christian Ottmann
A Binary Bivalent Supramolecular Assembly Platform Based on Cucurbit[8]uril and Dimeric Adapter Protein 14-3-3. Angewandte Chemie (International ed. in English) 56 (31) (2017)
David Bier, Sumit Mittal, Kenny Bravo-Rodriguez, Andrea Sowislok, Xavier Guillory, Jeroen Briels, Christian Heid, Maria Bartel, Burkhard Wettig, Luc Brunsveld, Elsa Sanchez-Garcia, Thomas Schrader, Christian Ottmann
The Molecular Tweezer CLR01 Stabilizes a Disordered Protein-Protein Interface. Journal of the American Chemical Society 139 (45) (2017)
Eline Sijbesma, Lukasz Skora, Seppe Leysen, Luc Brunsveld, Uwe Koch, Peter Nussbaumer, Wolfgang Jahnke, Christian Ottmann
Identification of Two Secondary Ligand Binding Sites in 14-3-3 Proteins Using Fragment Screening. Biochemistry 56 (30) (2017)
Arthur H A M van Onzen, Lorenzo Albertazzi, Albertus P H J Schenning, Lech-Gustav Milroy, Luc Brunsveld
Hydrophobicity determines the fate of self-assembled fluorescent nanoparticles in cells. Chemical communications (Cambridge, England) 53 (10) (2017)
Loes M Stevers, Eline Sijbesma, Maurizio Botta, Carol MacKintosh, Tomas Obsil, Isabelle Landrieu, Ylenia Cau, Andrew J Wilson, Anna Karawajczyk, Jan Eickhoff, Jeremy Davis, Michael Hann, Gavin O'Mahony, Richard G Doveston, Luc Brunsveld, Christian Ottmann
Modulators of 14-3-3 Protein-Protein Interactions. Journal of medicinal chemistry 61 (9) (2017)
Marcel Scheepstra, Sebastian A Andrei, Rens M J M de Vries, Femke A Meijer, Jian-Nong Ma, Ethan S Burstein, Roger Olsson, Christian Ottmann, Lech-Gustav Milroy, Luc Brunsveld
Ligand Dependent Switch from RXR Homo- to RXR-NURR1 Heterodimerization. ACS chemical neuroscience 8 (9) (2017)
Anniek den Hamer, Lenne J M Lemmens, Minke A D Nijenhuis, Christian Ottmann, Maarten Merkx, Tom F A de Greef, Luc Brunsveld
Small-Molecule-Induced and Cooperative Enzyme Assembly on a 14-3-3 Scaffold. Chembiochem : a European journal of chemical biology 18 (3) (2016)
Ralph P G Bosmans, Jeroen M Briels, Lech-Gustav Milroy, Tom F A de Greef, Maarten Merkx, Luc Brunsveld
Supramolecular Control over Split-Luciferase Complementation. Angewandte Chemie (International ed. in English) 55 (31) (2016)

Luc Brunsveld.css-eqlu8i{font-size:small;padding-left:4px;} (L Brunsveld)

Publication Activity (10 Years)

Top Topics

Top Venues

Luc Brunsveld (L Brunsveld)