Christian Ottmann

Publication Activity (10 Years)

Years Active: 2016-2024
Publications (10 Years): 67

Top Topics

Human Serum Albumin

Capillary Electrophoresis

Estrogen Receptor

Top Venues

Journal of medicinal chemistry

Journal of the American Chemical Society

ACS chemical neuroscience

Chembiochem : a European journal of chemical biology

This page only lists publications with an associated author ORCID identifier.

Publications

Blaž Andlovic, Dario Valenti, Federica Centorrino, Francesca Picarazzi, Stanimira Hristeva, Malgorzata Hiltmann, Alexander Wolf, François-Xavier Cantrelle, Mattia Mori, Isabelle Landrieu, Laura M Levy, Bert Klebl, Dimitrios Tzalis, Thorsten Genski, Jan Eickhoff, Christian Ottmann
Fragment-Based Interrogation of the 14-3-3/TAZ Protein-Protein Interaction. Biochemistry (2024)
Blaž Andlovic, Dario Valenti, Federica Centorrino, Francesca Picarazzi, Stanimira Hristeva, Malgorzata Hiltmann, Alexander Wolf, François-Xavier Cantrelle, Mattia Mori, Isabelle Landrieu, Laura M Levy, Bert Klebl, Dimitrios Tzalis, Thorsten Genski, Jan Eickhoff, Christian Ottmann
Fragment-Based Interrogation of the 14-3-3/TAZ Protein-Protein Interaction. Biochemistry 63 (17) (2024)
Liora S Katz, Emira J Visser, Kathrin F Plitzko, Marloes Pennings, Peter J Cossar, Isabelle L Tse, Markus Kaiser, Luc Brunsveld, Donald K Scott, Christian Ottmann
Molecular glues of the regulatory ChREBP/14-3-3 complex protect beta cells from glucolipotoxicity. bioRxiv : the preprint server for biology (2024)
Gobert Heesink, Maxime C M van den Oetelaar, Slav A Semerdzhiev, Christian Ottmann, Luc Brunsveld, Christian Blum, Mireille M A E Claessens
14-3-3τ as a Modulator of Early α-Synuclein Multimerization and Amyloid Formation. ACS chemical neuroscience (2024)
Gobert Heesink, Maxime C M van den Oetelaar, Slav A Semerdzhiev, Christian Ottmann, Luc Brunsveld, Christian Blum, Mireille M A E Claessens
14-3-3τ as a Modulator of Early α-Synuclein Multimerization and Amyloid Formation. ACS chemical neuroscience 15 (9) (2024)
Bente A Somsen, Peter J Cossar, Michelle R Arkin, Luc Brunsveld, Christian Ottmann
14-3-3 Protein-Protein Interactions: From Mechanistic Understanding to Their Small-Molecule Stabilization. Chembiochem : a European journal of chemical biology (2024)
Liora S Katz, Emira J Visser, Kathrin F Plitzko, Marloes Pennings, Peter J Cossar, Isabelle L Tse, Markus Kaiser, Luc Brunsveld, Donald K Scott, Christian Ottmann
Molecular glues of the regulatory ChREBP/14-3-3 complex protect beta cells from glucolipotoxicity. bioRxiv : the preprint server for biology (2024)
Gobert Heesink, Maxime C M van den Oetelaar, Slav A Semerdzhiev, Christian Ottmann, Luc Brunsveld, Christian Blum, Mireille M A E Claessens
14-3-3τ as a Modulator of Early α-Synuclein Multimerization and Amyloid Formation. ACS chemical neuroscience 15 (9) (2024)
Bente A Somsen, Peter J Cossar, Michelle R Arkin, Luc Brunsveld, Christian Ottmann
14-3-3 Protein-Protein Interactions: From Mechanistic Understanding to Their Small-Molecule Stabilization. Chembiochem : a European journal of chemical biology 25 (14) (2024)
Gobert Heesink, Maxime C M van den Oetelaar, Slav A Semerdzhiev, Christian Ottmann, Luc Brunsveld, Christian Blum, Mireille M A E Claessens
14-3-3τ as a Modulator of Early α-Synuclein Multimerization and Amyloid Formation. ACS chemical neuroscience 15 (9) (2024)
Gobert Heesink, Maxime C M van den Oetelaar, Slav A Semerdzhiev, Christian Ottmann, Luc Brunsveld, Christian Blum, Mireille M A E Claessens
14-3-3τ as a Modulator of Early α-Synuclein Multimerization and Amyloid Formation. ACS chemical neuroscience 15 (9) (2024)
Bente A Somsen, Peter J Cossar, Michelle R Arkin, Luc Brunsveld, Christian Ottmann
14-3-3 Protein-Protein Interactions: From Mechanistic Understanding to Their Small-Molecule Stabilization. Chembiochem : a European journal of chemical biology 25 (14) (2024)
Gobert Heesink, Maxime C M van den Oetelaar, Slav A Semerdzhiev, Christian Ottmann, Luc Brunsveld, Christian Blum, Mireille M A E Claessens
14-3-3τ as a Modulator of Early α-Synuclein Multimerization and Amyloid Formation. ACS chemical neuroscience 15 (9) (2024)
Jakob S Pallesen, Claire C Munier, Francesco Bosica, Sebastian A Andrei, Karl Edman, Anders Gunnarsson, Giuseppina La Sala, Okky Dwichandra Putra, Sonja Srdanović, Andrew J Wilson, Lisa Wissler, Christian Ottmann, Matthew W D Perry, Gavin O'Mahony
Correction to "Designing Selective Drug-like Molecular Glues for the Glucocorticoid Receptor/14-3-3 Protein-Protein Interaction". Journal of medicinal chemistry 66 (3) (2023)
Bente A Somsen, Rick J C Schellekens, Carlo J A Verhoef, Michelle R Arkin, Christian Ottmann, Peter J Cossar, Luc Brunsveld
Reversible Dual-Covalent Molecular Locking of the 14-3-3/ERRγ Protein-Protein Interaction as a Molecular Glue Drug Discovery Approach. Journal of the American Chemical Society (2023)
Ronen Gabizon, Barr Tivon, Rambabu N Reddi, Maxime C M van den Oetelaar, Hadar Amartely, Peter J Cossar, Christian Ottmann, Nir London
A simple method for developing lysine targeted covalent protein reagents. Nature communications 14 (1) (2023)
Dyana N Kenanova, Emira J Visser, Johanna M Virta, Eline Sijbesma, Federica Centorrino, Holly R Vickery, Mengqi Zhong, R Jeffrey Neitz, Luc Brunsveld, Christian Ottmann, Michelle R Arkin
A Systematic Approach to the Discovery of Protein-Protein Interaction Stabilizers. ACS central science 9 (5) (2023)
Jakob S Pallesen, Claire C Munier, Francesco Bosica, Sebastian A Andrei, Karl Edman, Anders Gunnarsson, Giuseppina La Sala, Okky Dwichandra Putra, Sonja Srdanović, Andrew J Wilson, Lisa Wissler, Christian Ottmann, Matthew W D Perry, Gavin O'Mahony
Correction to "Designing Selective Drug-like Molecular Glues for the Glucocorticoid Receptor/14-3-3 Protein-Protein Interaction". Journal of medicinal chemistry (2023)
Markella Konstantinidou, Emira J Visser, Edmee Vandenboorn, Sheng Chen, Priyadarshini Jaishankar, Maurits Overmans, Shubhankar Dutta, R Jeffrey Neitz, Adam R Renslo, Christian Ottmann, Luc Brunsveld, Michelle R Arkin
Structure-Based Optimization of Covalent, Small-Molecule Stabilizers of the 14-3-3σ/ERα Protein-Protein Interaction from Nonselective Fragments. Journal of the American Chemical Society (2023)
Jakob S Pallesen, Claire C Munier, Francesco Bosica, Sebastian A Andrei, Karl Edman, Anders Gunnarsson, Giuseppina La Sala, Okky Dwichandra Putra, Sonja Srdanović, Andrew J Wilson, Lisa Wissler, Christian Ottmann, Matthew W D Perry, Gavin O'Mahony
Correction to "Designing Selective Drug-like Molecular Glues for the Glucocorticoid Receptor/14-3-3 Protein-Protein Interaction". Journal of medicinal chemistry 66 (3) (2023)
Jakob S Pallesen, Claire C Munier, Francesco Bosica, Sebastian A Andrei, Karl Edman, Anders Gunnarsson, Giuseppina La Sala, Okky Dwichandra Putra, Sonja Srdanović, Andrew J Wilson, Lisa Wissler, Christian Ottmann, Matthew W D Perry, Gavin O'Mahony
Designing Selective Drug-like Molecular Glues for the Glucocorticoid Receptor/14-3-3 Protein-Protein Interaction. Journal of medicinal chemistry (2022)
Arjan Hazegh Nikroo, Lenne J M Lemmens, Tim Wezeman, Christian Ottmann, Maarten Merkx, Luc Brunsveld
Switchable Control of Scaffold Protein Activity via Engineered Phosphoregulated Autoinhibition. ACS synthetic biology 11 (7) (2022)
Hendrik J Brink, Jeffrey R van Senten, Ingrid J De Vries-van Leeuwen, Daniel da Costa Pereira, Sander R Piersma, Connie R Jimenez, Federica Centorrino, Christian Ottmann, Marco Siderius, Martine J Smit, Albertus H de Boer
Fusicoccin-A Targets Cancerous Inhibitor of Protein Phosphatase 2A by Stabilizing a C-Terminal Interaction with 14-3-3. ACS chemical biology 17 (11) (2022)
Loes M Stevers, Madita Wolter, Graeme W Carlile, Dwight Macdonald, Luc Richard, Frank Gielkens, John W Hanrahan, David Y Thomas, Sai Kumar Chakka, Mark L Peterson, Helmut Thomas, Luc Brunsveld, Christian Ottmann
Macrocycle-stabilization of its interaction with 14-3-3 increases plasma membrane localization and activity of CFTR. Nature communications 13 (1) (2022)
Bente A Somsen, Fenna W B Craenmehr, Wei-Hong W Liu, Auke A Koops, Marloes A M Pennings, Emira J Visser, Christian Ottmann, Peter J Cossar, Luc Brunsveld
Functional mapping of the 14-3-3 hub protein as a guide to design 14-3-3 molecular glues. Chemical science 13 (44) (2022)
Sonja Srdanović, Madita Wolter, Chi H Trinh, Christian Ottmann, Stuart L Warriner, Andrew J Wilson
Understanding the interaction of 14-3-3 proteins with hDMX and hDM2: a structural and biophysical study. The FEBS journal 289 (17) (2022)
Lorenzo Soini, Martin Redhead, Marta Westwood, Seppe Leysen, Jeremy Davis, Christian Ottmann
Identification of molecular glues of the SLP76/14-3-3 protein-protein interaction. RSC medicinal chemistry 12 (9) (2021)
Xavier Guillory, Inesa Hadrović, Pim J de Vink, Andrea Sowislok, Luc Brunsveld, Thomas Schrader, Christian Ottmann
Supramolecular Enhancement of a Natural 14-3-3 Protein Ligand. Journal of the American Chemical Society 143 (34) (2021)
Eline Sijbesma, Kenneth K Hallenbeck, Sebastian A Andrei, Reanne R Rust, Joris M C Adriaans, Luc Brunsveld, Michelle R Arkin, Christian Ottmann
Exploration of a 14-3-3 PPI Pocket by Covalent Fragments as Stabilizers. ACS medicinal chemistry letters 12 (6) (2021)
Peter J Cossar, Madita Wolter, Lars van Dijck, Dario Valenti, Laura M Levy, Christian Ottmann, Luc Brunsveld
Reversible Covalent Imine-Tethering for Selective Stabilization of 14-3-3 Hub Protein Interactions. Journal of the American Chemical Society 143 (22) (2021)
Madita Wolter, Dario Valenti, Peter J Cossar, Stanimira Hristeva, Laura M Levy, Thorsten Genski, Torsten Hoffmann, Luc Brunsveld, Dimitrios Tzalis, Christian Ottmann
An Exploration of Chemical Properties Required for Cooperative Stabilization of the 14-3-3 Interaction with NF-κB-Utilizing a Reversible Covalent Tethering Approach. Journal of medicinal chemistry 64 (12) (2021)
Ave Kuusk, Helen Boyd, Hongming Chen, Christian Ottmann
Small-molecule modulation of p53 protein-protein interactions. Biological chemistry 401 (8) (2021)
Femke A Meijer, Annet O W M Saris, Richard G Doveston, Guido J M Oerlemans, Rens M J M de Vries, Bente A Somsen, Anke Unger, Bert Klebl, Christian Ottmann, Peter J Cossar, Luc Brunsveld
Structure-Activity Relationship Studies of Trisubstituted Isoxazoles as Selective Allosteric Ligands for the Retinoic-Acid-Receptor-Related Orphan Receptor γt. Journal of medicinal chemistry 64 (13) (2021)
Barr Tivon, Ronen Gabizon, Bente A Somsen, Peter J Cossar, Christian Ottmann, Nir London
Covalent flexible peptide docking in Rosetta. Chemical science 12 (32) (2021)
Xiaolu Xu, Lenne J M Lemmens, Anniek den Hamer, Maarten Merkx, Christian Ottmann, Luc Brunsveld
Modular bioengineered kinase sensors via scaffold protein-mediated split-luciferase complementation. Chemical science 11 (21) (2020)
Alice Ballone, Francesca Picarazzi, Christine Prosser, Jeremy Davis, Christian Ottmann, Mattia Mori
Experimental and Computational Druggability Exploration of the 14-3-3ζ/SOS1pS1161 PPI Interface. Journal of chemical information and modeling 60 (12) (2020)
Domenico Lentini Santo, Olivia Petrvalska, Veronika Obsilova, Christian Ottmann, Tomas Obsil
Stabilization of Protein-Protein Interactions between CaMKK2 and 14-3-3 by Fusicoccins. ACS chemical biology 15 (11) (2020)
Alba Gigante, Eline Sijbesma, Pedro A Sánchez-Murcia, Xiaoyu Hu, David Bier, Sandra Bäcker, Shirley Knauer, Federico Gago, Christian Ottmann, Carsten Schmuck
A Supramolecular Stabilizer of the 14-3-3ζ/ERα Protein-Protein Interaction with a Synergistic Mode of Action. Angewandte Chemie (International ed. in English) 59 (13) (2020)
Ave Kuusk, João Filipe Neves, Kenny Bravo-Rodriguez, Anders Gunnarsson, Yasser B Ruiz-Blanco, Michael Ehrmann, Hongming Chen, Isabelle Landrieu, Elsa Sanchez-Garcia, Helen Boyd, Christian Ottmann, Richard G Doveston
Adoption of a Turn Conformation Drives the Binding Affinity of p53 C-Terminal Domain Peptides to 14-3-3σ. ACS chemical biology 15 (1) (2020)
Madita Wolter, Pim J de Vink, João Filipe Neves, Sonja Srdanović, Yusuke Higuchi, Nobuo Kato, Andrew J Wilson, Isabelle Landrieu, Luc Brunsveld, Christian Ottmann
Selectivity via Cooperativity: Preferential Stabilization of the p65/14-3-3 Interaction with Semisynthetic Natural Products. Journal of the American Chemical Society 142 (27) (2020)
Francesco Bosica, Sebastian A Andrei, João Filipe Neves, Peter Brandt, Anders Gunnarsson, Isabelle Landrieu, Christian Ottmann, Gavin O'Mahony
Design of Drug-Like Protein-Protein Interaction Stabilizers Guided By Chelation-Controlled Bioactive Conformation Stabilization. Chemistry (Weinheim an der Bergstrasse, Germany) 26 (31) (2020)
Lenne J M Lemmens, Christian Ottmann, Luc Brunsveld
Conjugated Protein Domains as Engineered Scaffold Proteins. Bioconjugate chemistry 31 (6) (2020)
Eline Sijbesma, Bente A Somsen, Galen P Miley, Iris A Leijten-van de Gevel, Luc Brunsveld, Michelle R Arkin, Christian Ottmann
Fluorescence Anisotropy-Based Tethering for Discovery of Protein-Protein Interaction Stabilizers. ACS chemical biology 15 (12) (2020)
Lorenzo Soini, Seppe Leysen, Jeremy Davis, Marta Westwood, Christian Ottmann
The 14-3-3/SLP76 protein-protein interaction in T-cell receptor signalling: a structural and biophysical characterization. FEBS letters 595 (3) (2020)
Madita Wolter, Dario Valenti, Peter J Cossar, Laura M Levy, Stanimira Hristeva, Thorsten Genski, Torsten Hoffmann, Luc Brunsveld, Dimitrios Tzalis, Christian Ottmann
Fragment-Based Stabilizers of Protein-Protein Interactions through Imine-Based Tethering. Angewandte Chemie (International ed. in English) 59 (48) (2020)
Xavier Guillory, Madita Wolter, Seppe Leysen, João Filipe Neves, Ave Kuusk, Sylvia Genet, Bente Somsen, John Kenneth Morrow, Emma Rivers, Lotte van Beek, Joe Patel, Robert Goodnow, Heike Schoenherr, Nathan Fuller, Qing Cao, Richard G Doveston, Luc Brunsveld, Michelle R Arkin, Paola Castaldi, Helen Boyd, Isabelle Landrieu, Hongming Chen, Christian Ottmann
Fragment-based Differential Targeting of PPI Stabilizer Interfaces. Journal of medicinal chemistry 63 (13) (2020)
Julia Menzel, Daniel Kownatzki-Danger, Sergiy Tokar, Alice Ballone, Kirsten Unthan-Fechner, Markus Kilisch, Christof Lenz, Henning Urlaub, Mattia Mori, Christian Ottmann, Michael J Shattock, Stephan E Lehnart, Blanche Schwappach
14-3-3 binding creates a memory of kinase action by stabilizing the modified state of phospholamban. Science signaling 13 (647) (2020)
Lina Bartsch, Maria Bartel, Alba Gigante, Javier Iglesias-Fernández, Yasser B Ruiz-Blanco, Christine Beuck, Jeroen Briels, Niklas Toetsch, Peter Bayer, Elsa Sanchez-Garcia, Christian Ottmann, Carsten Schmuck
Multivalent Ligands with Tailor-Made Anion Binding Motif as Stabilizers of Protein-Protein Interactions. Chembiochem : a European journal of chemical biology 20 (23) (2019)
Dario Valenti, João Filipe Neves, François-Xavier Cantrelle, Stanimira Hristeva, Domenico Lentini Santo, Tomáš Obšil, Xavier Hanoulle, Laura M Levy, Dimitrios Tzalis, Isabelle Landrieu, Christian Ottmann
Set-up and screening of a fragment library targeting the 14-3-3 protein interface. MedChemComm 10 (10) (2019)
Pim J de Vink, Sebastian A Andrei, Yusuke Higuchi, Christian Ottmann, Lech-Gustav Milroy, Luc Brunsveld
Cooperativity basis for small-molecule stabilization of protein-protein interactions. Chemical science 10 (10) (2019)
Eric Valeur, Frank Narjes, Christian Ottmann, Alleyn T Plowright
Emerging modes-of-action in drug discovery. MedChemComm 10 (9) (2019)
Femke A Meijer, Richard G Doveston, Rens M J M de Vries, Gaël M Vos, Alex A A Vos, Seppe Leysen, Marcel Scheepstra, Christian Ottmann, Lech-Gustav Milroy, Luc Brunsveld
Ligand-Based Design of Allosteric Retinoic Acid Receptor-Related Orphan Receptor γt (RORγt) Inverse Agonists. Journal of medicinal chemistry 63 (1) (2019)
Eline Sijbesma, Kenneth K Hallenbeck, Seppe Leysen, Pim J de Vink, Lukasz Skóra, Wolfgang Jahnke, Luc Brunsveld, Michelle R Arkin, Christian Ottmann
Site-Directed Fragment-Based Screening for the Discovery of Protein-Protein Interaction Stabilizers. Journal of the American Chemical Society 141 (8) (2019)
Sebastian A Andrei, Pim J de Vink, Eline Sijbesma, Ling Han, Luc Brunsveld, Nobuo Kato, Christian Ottmann, Yusuke Higuchi
Rationally Designed Semisynthetic Natural Product Analogues for Stabilization of 14-3-3 Protein-Protein Interactions. Angewandte Chemie (International ed. in English) 57 (41) (2018)
Sebastian A Andrei, Femke A Meijer, João Filipe Neves, Luc Brunsveld, Isabelle Landrieu, Christian Ottmann, Lech-Gustav Milroy
Inhibition of 14-3-3/Tau by Hybrid Small-Molecule Peptides Operating via Two Different Binding Modes. ACS chemical neuroscience 9 (11) (2018)
Jean-Noël Grad, Alba Gigante, Christoph Wilms, Jan Nikolaj Dybowski, Ludwig Ohl, Christian Ottmann, Carsten Schmuck, Daniel Hoffmann
Locating Large, Flexible Ligands on Proteins. Journal of chemical information and modeling 58 (2) (2018)
Loes M Stevers, Pim J de Vink, Christian Ottmann, Jurriaan Huskens, Luc Brunsveld
A Thermodynamic Model for Multivalency in 14-3-3 Protein-Protein Interactions. Journal of the American Chemical Society 140 (43) (2018)
Stijn J A Aper, Anniek den Hamer, Simone F A Wouters, Lenne J M Lemmens, Christian Ottmann, Luc Brunsveld, Maarten Merkx
Protease-Activatable Scaffold Proteins as Versatile Molecular Hubs in Synthetic Signaling Networks. ACS synthetic biology 7 (9) (2018)
Alice Ballone, Federica Centorrino, Christian Ottmann
14-3-3: A Case Study in PPI Modulation. Molecules (Basel, Switzerland) 23 (6) (2018)
Sam van Dun, Christian Ottmann, Lech-Gustav Milroy, Luc Brunsveld
Supramolecular Chemistry Targeting Proteins. Journal of the American Chemical Society 139 (40) (2017)
Pim J de Vink, Jeroen M Briels, Thomas Schrader, Lech-Gustav Milroy, Luc Brunsveld, Christian Ottmann
A Binary Bivalent Supramolecular Assembly Platform Based on Cucurbit[8]uril and Dimeric Adapter Protein 14-3-3. Angewandte Chemie (International ed. in English) 56 (31) (2017)
David Bier, Sumit Mittal, Kenny Bravo-Rodriguez, Andrea Sowislok, Xavier Guillory, Jeroen Briels, Christian Heid, Maria Bartel, Burkhard Wettig, Luc Brunsveld, Elsa Sanchez-Garcia, Thomas Schrader, Christian Ottmann
The Molecular Tweezer CLR01 Stabilizes a Disordered Protein-Protein Interface. Journal of the American Chemical Society 139 (45) (2017)
Eline Sijbesma, Lukasz Skora, Seppe Leysen, Luc Brunsveld, Uwe Koch, Peter Nussbaumer, Wolfgang Jahnke, Christian Ottmann
Identification of Two Secondary Ligand Binding Sites in 14-3-3 Proteins Using Fragment Screening. Biochemistry 56 (30) (2017)
Loes M Stevers, Eline Sijbesma, Maurizio Botta, Carol MacKintosh, Tomas Obsil, Isabelle Landrieu, Ylenia Cau, Andrew J Wilson, Anna Karawajczyk, Jan Eickhoff, Jeremy Davis, Michael Hann, Gavin O'Mahony, Richard G Doveston, Luc Brunsveld, Christian Ottmann
Modulators of 14-3-3 Protein-Protein Interactions. Journal of medicinal chemistry 61 (9) (2017)
Marcel Scheepstra, Sebastian A Andrei, Rens M J M de Vries, Femke A Meijer, Jian-Nong Ma, Ethan S Burstein, Roger Olsson, Christian Ottmann, Lech-Gustav Milroy, Luc Brunsveld
Ligand Dependent Switch from RXR Homo- to RXR-NURR1 Heterodimerization. ACS chemical neuroscience 8 (9) (2017)
Dennis M Krüger, Adrian Glas, David Bier, Nicole Pospiech, Kerstin Wallraven, Laura Dietrich, Christian Ottmann, Oliver Koch, Sven Hennig, Tom N Grossmann
Structure-Based Design of Non-natural Macrocyclic Peptides That Inhibit Protein-Protein Interactions. Journal of medicinal chemistry 60 (21) (2017)
Anniek den Hamer, Lenne J M Lemmens, Minke A D Nijenhuis, Christian Ottmann, Maarten Merkx, Tom F A de Greef, Luc Brunsveld
Small-Molecule-Induced and Cooperative Enzyme Assembly on a 14-3-3 Scaffold. Chembiochem : a European journal of chemical biology 18 (3) (2016)