Adam R Renslo

ORCID

Publication Activity (10 Years)

Years Active: 2016-2024
Publications (10 Years): 45

Top Venues

Proceedings of the National Academy of Sciences of the United States of America

Journal of the American Chemical Society

ACS infectious diseases

bioRxiv : the preprint server for biology

University of California San Francisco

Massachusetts Institute of Technology (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

University of California San Francisco

United States

Professor :: Pharmaceutical Chemistry

Small Molecule Discovery Center

United States

Associate Director :: Chemistry

University of California San Francisco

United States

Associate Adjunct Professor

University of California San Francisco

United States

Assistant Adjunct Professor

Vicuron Pharmaceuticals

United States

Associate Director :: Medicinal Chemistry

Vicuron Pharmaceuticals

United States

Group Leader :: Medicinal Chemistry

Vicuron Pharmaceuticals

United States

Senior Scientist :: Medicinal Chemistry

Education History

Massachusetts Institute of Technology

United States

PHD

Publications

Rahul K Suryawanshi, Priyadarshini Jaishankar, Galen J Correy, Moira M Rachman, Patrick C O'Leary, Taha Y Taha, Francisco J Zapatero-Belinchón, Maria McCavitt-Malvido, Yagmur Umay Doruk, Maisie G V Stevens, Morgan E Diolati, Manasi P Jogalekar, Alicia L Richards, Mauricio Montano, Julia Rosecrans, Michael A Matthay, Takaya Togo, Ryan L Gonciarz, Saumya Gopalkrishnan, R Jeffrey Neitz, Nevan J Krogan, Danielle L Swaney, Brian K Shoichet, Melanie M Ott, Adam R Renslo, Alan Ashworth, Brian K Shoichet
The Mac1 ADP-ribosylhydrolase is a Therapeutic Target for SARS-CoV-2. bioRxiv : the preprint server for biology (2024)
Aidan T Pezacki, Ryan L Gonciarz, Toshitaka Okamura, Carson D Matier, Laura Torrente, Ke Cheng, Sophia G Miller, Martina Ralle, Nathan P Ward, Gina M DeNicola, Adam R Renslo, Christopher J Chang
A tandem activity-based sensing and labeling strategy reveals antioxidant response element regulation of labile iron pools. Proceedings of the National Academy of Sciences of the United States of America 121 (28) (2024)
Rahul K Suryawanshi, Priyadarshini Jaishankar, Galen J Correy, Moira M Rachman, Patrick C O'Leary, Taha Y Taha, Francisco J Zapatero-Belinchón, Maria McCavitt-Malvido, Yagmur Umay Doruk, Maisie G V Stevens, Morgan E Diolati, Manasi P Jogalekar, Alicia L Richards, Mauricio Montano, Julia Rosecrans, Michael A Matthay, Takaya Togo, Ryan L Gonciarz, Saumya Gopalkrishnan, R Jeffrey Neitz, Nevan J Krogan, Danielle L Swaney, Brian K Shoichet, Melanie M Ott, Adam R Renslo, Alan Ashworth, Brian K Shoichet
The Mac1 ADP-ribosylhydrolase is a Therapeutic Target for SARS-CoV-2. bioRxiv : the preprint server for biology (2024)
Aidan T Pezacki, Ryan L Gonciarz, Toshitaka Okamura, Carson D Matier, Laura Torrente, Ke Cheng, Sophia G Miller, Martina Ralle, Nathan P Ward, Gina M DeNicola, Adam R Renslo, Christopher J Chang
A tandem activity-based sensing and labeling strategy reveals antioxidant response element regulation of labile iron pools. Proceedings of the National Academy of Sciences of the United States of America 121 (28) (2024)
Aidan T Pezacki, Ryan L Gonciarz, Toshitaka Okamura, Carson D Matier, Laura Torrente, Ke Cheng, Sophia G Miller, Martina Ralle, Nathan P Ward, Gina M DeNicola, Adam R Renslo, Christopher J Chang
A tandem activity-based sensing and labeling strategy reveals antioxidant response element regulation of labile iron pools. Proceedings of the National Academy of Sciences of the United States of America 121 (28) (2024)
Galen J Correy, Moira M Rachman, Takaya Togo, Stefan Gahbauer, Yagmur Umay Doruk, Maisie G V Stevens, Priyadarshini Jaishankar, Brian Kelley, Brian Goldman, Molly Schmidt, Trevor Kramer, Alan Ashworth, Patrick F Riley, Brian K Shoichet, Adam R Renslo, W Patrick Walters, Brian K Shoichet
Extensive exploration of structure activity relationships for the SARS-CoV-2 macrodomain from shape-based fragment merging and active learning. bioRxiv : the preprint server for biology (2024)
Kurt S Van Horn, Dongju Wang, Daniel Medina-Cleghorn, Peter S Lee, Clifford Bryant, Chad Altobelli, Priyadarshini Jaishankar, Kevin K Leung, Raymond A Ng, Andrew J Ambrose, Yinyan Tang, Michelle R Arkin, Adam R Renslo
Engaging a Non-catalytic Cysteine Residue Drives Potent and Selective Inhibition of Caspase-6. Journal of the American Chemical Society 145 (18) (2023)
Stefan Gahbauer, Galen J Correy, Marion Schuller, Matteo P Ferla, Yagmur Umay Doruk, Moira M Rachman, Taiasean Wu, Morgan E Diolati, Siyi Wang, R Jeffrey Neitz, Daren Fearon, Dmytro S Radchenko, Yurii S Moroz, John J Irwin, Adam R Renslo, Jenny C Taylor, Jason E Gestwicki, Frank von Delft, Alan Ashworth, Ivan Ahel, Brian K Shoichet, Brian K Shoichet
Iterative computational design and crystallographic screening identifies potent inhibitors targeting the Nsp3 macrodomain of SARS-CoV-2. Proceedings of the National Academy of Sciences of the United States of America 120 (2) (2023)
Takaya Togo, Linh Tram, Laura G Denton, Xochina ElHilali-Pollard, Jun Gu, Jinglei Jiang, Chenglei Liu, Yan Zhao, Yanlong Zhao, Yinzhe Zheng, Yunping Zheng, Jingjing Yang, Panpan Fan, Michelle R Arkin, Harri Härmä, Deqian Sun, Stacie S Canan, Steven E Wheeler, Adam R Renslo
Systematic Study of Heteroarene Stacking Using a Congeneric Set of Molecular Glues for Procaspase-6. Journal of medicinal chemistry (2023)
Kurt S Van Horn, Dongju Wang, Daniel Medina-Cleghorn, Peter S Lee, Clifford Bryant, Chad Altobelli, Priyadarshini Jaishankar, Kevin K Leung, Raymond A Ng, Andrew J Ambrose, Yinyan Tang, Michelle R Arkin, Adam R Renslo
Engaging a Non-catalytic Cysteine Residue Drives Potent and Selective Inhibition of Caspase-6. Journal of the American Chemical Society 145 (18) (2023)
Brian R Blank, Jiri Gut, Philip J Rosenthal, Adam R Renslo
Artefenomel Regioisomer RLA-3107 Is a Promising Lead for the Discovery of Next-Generation Endoperoxide Antimalarials. ACS medicinal chemistry letters 14 (4) (2023)
Stefan Gahbauer, Galen J Correy, Marion Schuller, Matteo P Ferla, Yagmur Umay Doruk, Moira M Rachman, Taiasean Wu, Morgan E Diolati, Siyi Wang, R Jeffrey Neitz, Daren Fearon, Dmytro S Radchenko, Yurii S Moroz, John J Irwin, Adam R Renslo, Jenny C Taylor, Jason E Gestwicki, Frank von Delft, Alan Ashworth, Ivan Ahel, Brian K Shoichet, Brian K Shoichet
Iterative computational design and crystallographic screening identifies potent inhibitors targeting the Nsp3 macrodomain of SARS-CoV-2. Proceedings of the National Academy of Sciences of the United States of America 120 (2) (2023)
Markella Konstantinidou, Emira J Visser, Edmee Vandenboorn, Sheng Chen, Priyadarshini Jaishankar, Maurits Overmans, Shubhankar Dutta, R Jeffrey Neitz, Adam R Renslo, Christian Ottmann, Luc Brunsveld, Michelle R Arkin
Structure-Based Optimization of Covalent, Small-Molecule Stabilizers of the 14-3-3σ/ERα Protein-Protein Interaction from Nonselective Fragments. Journal of the American Chemical Society (2023)
Stefan Gahbauer, Galen J Correy, Marion Schuller, Matteo P Ferla, Yagmur Umay Doruk, Moira M Rachman, Taiasean Wu, Morgan E Diolati, Siyi Wang, R Jeffrey Neitz, Daren Fearon, Dmytro S Radchenko, Yurii S Moroz, John J Irwin, Adam R Renslo, Jenny C Taylor, Jason E Gestwicki, Frank von Delft, Alan Ashworth, Ivan Ahel, Brian K Shoichet, Brian K Shoichet
Iterative computational design and crystallographic screening identifies potent inhibitors targeting the Nsp3 macrodomain of SARS-CoV-2. Proceedings of the National Academy of Sciences of the United States of America 120 (2) (2023)
Kurt S Van Horn, Dongju Wang, Daniel Medina-Cleghorn, Peter S Lee, Clifford Bryant, Chad Altobelli, Priyadarshini Jaishankar, Kevin K Leung, Raymond A Ng, Andrew J Ambrose, Yinyan Tang, Michelle R Arkin, Adam R Renslo
Engaging a Non-catalytic Cysteine Residue Drives Potent and Selective Inhibition of Caspase-6. Journal of the American Chemical Society 145 (18) (2023)
Stefan Gahbauer, Galen J Correy, Marion Schuller, Matteo P Ferla, Yagmur Umay Doruk, Moira M Rachman, Taiasean Wu, Morgan E Diolati, Siyi Wang, R Jeffrey Neitz, Daren Fearon, Dmytro S Radchenko, Yurii S Moroz, John J Irwin, Adam R Renslo, Jenny C Taylor, Jason E Gestwicki, Frank von Delft, Alan Ashworth, Ivan Ahel, Brian K Shoichet, Brian K Shoichet
Iterative computational design and crystallographic screening identifies potent inhibitors targeting the Nsp3 macrodomain of SARS-CoV-2. Proceedings of the National Academy of Sciences of the United States of America 120 (2) (2023)
Stefan Gahbauer, Galen J Correy, Marion Schuller, Matteo P Ferla, Yagmur Umay Doruk, Moira M Rachman, Taiasean Wu, Morgan E Diolati, Siyi Wang, R Jeffrey Neitz, Daren Fearon, Dmytro S Radchenko, Yurii S Moroz, John J Irwin, Adam R Renslo, Jenny C Taylor, Jason E Gestwicki, Frank von Delft, Alan Ashworth, Ivan Ahel, Brian K Shoichet, Brian K Shoichet
Iterative computational design and crystallographic screening identifies potent inhibitors targeting the Nsp3 macrodomain of SARS-CoV-2. Proceedings of the National Academy of Sciences of the United States of America 120 (2) (2023)
Stefan Gahbauer, Galen J Correy, Marion Schuller, Matteo P Ferla, Yagmur Umay Doruk, Moira M Rachman, Taiasean Wu, Morgan E Diolati, Siyi Wang, R Jeffrey Neitz, Daren Fearon, Dmytro S Radchenko, Yurii S Moroz, John J Irwin, Adam R Renslo, Jenny C Taylor, Jason E Gestwicki, Frank von Delft, Alan Ashworth, Ivan Ahel, Brian K Shoichet, Brian K Shoichet
Iterative computational design and crystallographic screening identifies potent inhibitors targeting the Nsp3 macrodomain of SARS-CoV-2. Proceedings of the National Academy of Sciences of the United States of America 120 (2) (2023)
Kurt S Van Horn, Dongju Wang, Daniel Medina-Cleghorn, Peter S Lee, Clifford Bryant, Chad Altobelli, Priyadarshini Jaishankar, Kevin K Leung, Raymond A Ng, Andrew J Ambrose, Yinyan Tang, Michelle R Arkin, Adam R Renslo
Engaging a Non-catalytic Cysteine Residue Drives Potent and Selective Inhibition of Caspase-6. Journal of the American Chemical Society (2023)
Stefan Gahbauer, Galen J Correy, Marion Schuller, Matteo P Ferla, Yagmur Umay Doruk, Moira M Rachman, Taiasean Wu, Morgan E Diolati, Siyi Wang, R Jeffrey Neitz, Daren Fearon, Dmytro S Radchenko, Yurii S Moroz, John J Irwin, Adam R Renslo, Jenny C Taylor, Jason E Gestwicki, Frank von Delft, Alan Ashworth, Ivan Ahel, Brian K Shoichet, Brian K Shoichet
Iterative computational design and crystallographic screening identifies potent inhibitors targeting the Nsp3 macrodomain of SARS-CoV-2. Proceedings of the National Academy of Sciences of the United States of America 120 (2) (2023)
Stefan Gahbauer, Galen J Correy, Marion Schuller, Matteo P Ferla, Yagmur Umay Doruk, Moira M Rachman, Taiasean Wu, Morgan E Diolati, Siyi Wang, R Jeffrey Neitz, Daren Fearon, Dmytro S Radchenko, Yurii S Moroz, John J Irwin, Adam R Renslo, Jenny C Taylor, Jason E Gestwicki, Frank von Delft, Alan Ashworth, Ivan Ahel, Brian K Shoichet, Brian K Shoichet
Iterative computational design and crystallographic screening identifies potent inhibitors targeting the Nsp3 macrodomain of SARS-CoV-2. Proceedings of the National Academy of Sciences of the United States of America 120 (2) (2023)
Kurt S Van Horn, Dongju Wang, Daniel Medina-Cleghorn, Peter S Lee, Clifford Bryant, Chad Altobelli, Priyadarshini Jaishankar, Kevin K Leung, Raymond A Ng, Andrew J Ambrose, Yinyan Tang, Michelle R Arkin, Adam R Renslo
Engaging a Non-catalytic Cysteine Residue Drives Potent and Selective Inhibition of Caspase-6. Journal of the American Chemical Society 145 (18) (2023)
Kurt S Van Horn, Dongju Wang, Daniel Medina-Cleghorn, Peter S Lee, Clifford Bryant, Chad Altobelli, Priyadarshini Jaishankar, Kevin K Leung, Raymond A Ng, Andrew J Ambrose, Yinyan Tang, Michelle R Arkin, Adam R Renslo
Engaging a Non-catalytic Cysteine Residue Drives Potent and Selective Inhibition of Caspase-6. Journal of the American Chemical Society 145 (18) (2023)
Hiroki Shimizu, Adam R Renslo
Systematic Exploration of Passive Permeability in Tetrapeptides with Hydrogen-Bond-Accepting Amino Acid Side Chains. ChemMedChem 17 (16) (2022)
Michael D Sacco, Kyle Defrees, Xiujun Zhang, William Lawless, Emeka Nwanochie, Amelia Balsizer, Sophie E Darch, Adam R Renslo, Yu Chen
Structure-Based Ligand Design Targeting Pseudomonas aeruginosa LpxA in Lipid A Biosynthesis. ACS infectious diseases 8 (7) (2022)
Honglin Jiang, Ryan K Muir, Ryan L Gonciarz, Adam B Olshen, Iwei Yeh, Byron C Hann, Ning Zhao, Yung-Hua Wang, Spencer C Behr, James E Korkola, Kenneth W Bayles, Eric A Collisson, Adam R Renslo
Ferrous iron-activatable drug conjugate achieves potent MAPK blockade in KRAS-driven tumors. The Journal of experimental medicine 219 (4) (2022)
Stefan Gahbauer, Galen J Correy, Marion Schuller, Matteo P Ferla, Yagmur Umay Doruk, Moira M Rachman, Taiasean Wu, Morgan E Diolati, Siyi Wang, R Jeffrey Neitz, Daren Fearon, Dmytro S Radchenko, Yurii S Moroz, John J Irwin, Adam R Renslo, Jenny C Taylor, Jason E Gestwicki, Frank von Delft, Alan Ashworth, Ivan Ahel, Brian K Shoichet, Brian K Shoichet
Structure-based inhibitor optimization for the Nsp3 Macrodomain of SARS-CoV-2. bioRxiv : the preprint server for biology (2022)
Jun Chen, Ryan L Gonciarz, Adam R Renslo
Expanded scope of Griesbaum co-ozonolysis for the preparation of structurally diverse sensors of ferrous iron. RSC advances 11 (54) (2021)
Charlene Bashore, Priyadarshini Jaishankar, Nicholas J Skelton, Jakob Fuhrmann, Brian R Hearn, Peter S Liu, Adam R Renslo, Erin C Dueber
Cyanopyrrolidine Inhibitors of Ubiquitin Specific Protease 7 Mediate Desulfhydration of the Active-Site Cysteine. ACS chemical biology 15 (6) (2020)
Brian R Blank, Ryan L Gonciarz, Poulami Talukder, Jiri Gut, Jennifer Legac, Philip J Rosenthal, Adam R Renslo
Antimalarial Trioxolanes with Superior Drug-Like Properties and In Vivo Efficacy. ACS infectious diseases 6 (7) (2020)
Adéla Jílková, Petra Rubešová, Jindřich Fanfrlík, Pavla Fajtová, Pavlína Řezáčová, Jiří Brynda, Martin Lepsik, Helena Mertlíková-Kaiserová, Cory D Emal, Adam R Renslo, William R Roush, Martin Horn, Conor R Caffrey, Michael Mareš
Druggable Hot Spots in the Schistosomiasis Cathepsin B1 Target Identified by Functional and Binding Mode Analysis of Potent Vinyl Sulfone Inhibitors. ACS infectious diseases 7 (5) (2020)
Ying-Chu Chen, Juan A Oses-Prieto, Lauren E Pope, Alma L Burlingame, Scott J Dixon, Adam R Renslo
Reactivity-Based Probe of the Iron(II)-Dependent Interactome Identifies New Cellular Modulators of Ferroptosis. Journal of the American Chemical Society 142 (45) (2020)
Tyler C Huff, Vladimir Camarena, David W Sant, Zachary Wilkes, Derek Van Booven, Allegra T Aron, Ryan K Muir, Adam R Renslo, Christopher J Chang, Paula V Monje, Gaofeng Wang
Oscillatory cAMP signaling rapidly alters H3K4 methylation. Life science alliance 3 (1) (2019)
Brian R Blank, Poulami Talukder, Ryan K Muir, Erin R Green, Eric P Skaar, Adam R Renslo
Targeting Mobilization of Ferrous Iron in Pseudomonas aeruginosa Infection with an Iron(II)-Caged LpxC Inhibitor. ACS infectious diseases 5 (8) (2019)
Orville A Pemberton, Priyadarshini Jaishankar, Afroza Akhtar, Jessie L Adams, Lindsey Neil Shaw, Adam R Renslo, Yu Chen
Heteroaryl Phosphonates as Noncovalent Inhibitors of Both Serine- and Metallocarbapenemases. Journal of medicinal chemistry 62 (18) (2019)
Nicholas J Torelli, Afroza Akhtar, Kyle DeFrees, Priyadarshini Jaishankar, Orville A Pemberton, Xiujun Zhang, Cody Johnson, Adam R Renslo, Yu Chen
Active-Site Druggability of Carbapenemases and Broad-Spectrum Inhibitor Discovery. ACS infectious diseases 5 (6) (2019)
Jordan C Tsai, Lakshmi E Miller-Vedam, Aditya A Anand, Priyadarshini Jaishankar, Henry C Nguyen, Adam R Renslo, Adam Frost, Peter Walter
Structure of the nucleotide exchange factor eIF2B reveals mechanism of memory-enhancing molecule. Science (New York, N.Y.) 359 (6383) (2018)
Benjamin Spangler, Toni Kline, Jeffrey Hanson, Xiaofan Li, Sihong Zhou, James A Wells, Aaron K Sato, Adam R Renslo
Toward a Ferrous Iron-Cleavable Linker for Antibody-Drug Conjugates. Molecular pharmaceutics 15 (5) (2018)
Lianne Pope, Cristina Arrigoni, Hubing Lou, Clifford Bryant, Alejandra Gallardo-Godoy, Adam R Renslo, Daniel L Minor
Protein and Chemical Determinants of BL-1249 Action and Selectivity for K2P Channels. ACS chemical neuroscience 9 (12) (2018)
Orville A Pemberton, Xiujun Zhang, Derek A Nichols, Kyle DeFrees, Priyadarshini Jaishankar, Richard Bonnet, Jessie Adams, Lindsey Neil Shaw, Adam R Renslo, Yu Chen
Antibacterial Spectrum of a Tetrazole-Based Reversible Inhibitor of Serine β-Lactamases. Antimicrobial agents and chemotherapy 62 (8) (2018)
Robert L Nakamura, Mark A Burlingame, Shumin Yang, David C Crosby, Dale J Talbot, Kitty Chui, Alan D Frankel, Adam R Renslo
Identification and Optimization of Thienopyridine Carboxamides as Inhibitors of HIV Regulatory Complexes. Antimicrobial agents and chemotherapy 61 (7) (2017)
Brian R Blank, Jiri Gut, Philip J Rosenthal, Adam R Renslo
Enantioselective Synthesis and in Vivo Evaluation of Regioisomeric Analogues of the Antimalarial Arterolane. Journal of medicinal chemistry 60 (14) (2017)
Timothy M Acker, Jonathan E Gable, Markus-Frederik Bohn, Priyadarshini Jaishankar, Michael C Thompson, James S Fraser, Adam R Renslo, Charles S Craik
Allosteric Inhibitors, Crystallography, and Comparative Analysis Reveal Network of Coordinated Movement across Human Herpesvirus Proteases. Journal of the American Chemical Society 139 (34) (2017)
Allegra T Aron, Marie C Heffern, Zachery R Lonergan, Mark N Vander Wal, Brian R Blank, Benjamin Spangler, Yaofang Zhang, Hyo Min Park, Andreas Stahl, Adam R Renslo, Eric P Skaar, Christopher J Chang
In vivo bioluminescence imaging of labile iron accumulation in a murine model of Acinetobacter baumannii infection. Proceedings of the National Academy of Sciences of the United States of America 114 (48) (2017)
Benjamin Spangler, Shaun D Fontaine, Yihui Shi, Lidia Sambucetti, Aras N Mattis, Byron Hann, James A Wells, Adam R Renslo
A Novel Tumor-Activated Prodrug Strategy Targeting Ferrous Iron Is Effective in Multiple Preclinical Cancer Models. Journal of medicinal chemistry 59 (24) (2016)

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Publication Activity (10 Years)

Top Topics

Top Venues

Adam R Renslo