Marcus Fischer

Publication Activity (10 Years)

Years Active: 2018-2024
Publications (10 Years): 22

Top Topics

Molecular Dynamics Simulations

Acute Lymphoblastic Leukemia

Top Venues

Nature communications

Nature chemical biology

Acta crystallographica. Section D, Structural biology

Journal of applied crystallography

This page only lists publications with an associated author ORCID identifier.

Publications

Caitlin D Deane, Marcus Fischer, Anang A Shelat
Bringing chemistry to medicine to redefine the undruggable. Nature chemical biology 20 (7) (2024)
Gisele Nishiguchi, Lauren G Mascibroda, Sarah M Young, Elizabeth A Caine, Sherif Abdelhamed, Jeffrey J Kooijman, Darcie J Miller, Sourav Das, Kevin McGowan, Anand Mayasundari, Zhe Shi, Juan M Barajas, Ryan Hiltenbrand, Anup Aggarwal, Yunchao Chang, Vibhor Mishra, Shilpa Narina, Melvin Thomas, Allister J Loughran, Ravi C Kalathur, Kaiwen Yu, Suiping Zhou, Xusheng Wang, Anthony A High, Junmin Peng, Shondra M Pruett-Miller, Danette L Daniels, Marjeta Urh, Anang A Shelat, Charles G Mullighan, Kristin M Riching, Guido J R Zaman, Marcus Fischer, Jeffery M Klco, Zoran Rankovic
Selective CK1α degraders exert antiproliferative activity against a broad range of human cancer cell lines. Nature communications 15 (1) (2024)
Timothy R Stachowski, Marcus Fischer
FLEXR GUI: a graphical user interface for multi-conformer modeling of proteins. Journal of applied crystallography 57 (Pt 2) (2024)
Gisele Nishiguchi, Lauren G Mascibroda, Sarah M Young, Elizabeth A Caine, Sherif Abdelhamed, Jeffrey J Kooijman, Darcie J Miller, Sourav Das, Kevin McGowan, Anand Mayasundari, Zhe Shi, Juan M Barajas, Ryan Hiltenbrand, Anup Aggarwal, Yunchao Chang, Vibhor Mishra, Shilpa Narina, Melvin Thomas, Allister J Loughran, Ravi C Kalathur, Kaiwen Yu, Suiping Zhou, Xusheng Wang, Anthony A High, Junmin Peng, Shondra M Pruett-Miller, Danette L Daniels, Marjeta Urh, Anang A Shelat, Charles G Mullighan, Kristin M Riching, Guido J R Zaman, Marcus Fischer, Jeffery M Klco, Zoran Rankovic
Selective CK1α degraders exert antiproliferative activity against a broad range of human cancer cell lines. Nature communications 15 (1) (2024)
Caitlin D Deane, Marcus Fischer, Anang A Shelat
Bringing chemistry to medicine to redefine the undruggable. Nature chemical biology 20 (7) (2024)
Caitlin D Deane, Marcus Fischer, Anang A Shelat
Bringing chemistry to medicine to redefine the undruggable. Nature chemical biology (2024)
Gisele Nishiguchi, Lauren G Mascibroda, Sarah M Young, Elizabeth A Caine, Sherif Abdelhamed, Jeffrey J Kooijman, Darcie J Miller, Sourav Das, Kevin McGowan, Anand Mayasundari, Zhe Shi, Juan M Barajas, Ryan Hiltenbrand, Anup Aggarwal, Yunchao Chang, Vibhor Mishra, Shilpa Narina, Melvin Thomas, Allister J Loughran, Ravi C Kalathur, Kaiwen Yu, Suiping Zhou, Xusheng Wang, Anthony A High, Junmin Peng, Shondra M Pruett-Miller, Danette L Daniels, Marjeta Urh, Anang A Shelat, Charles G Mullighan, Kristin M Riching, Guido J R Zaman, Marcus Fischer, Jeffery M Klco, Zoran Rankovic
Selective CK1α degraders exert antiproliferative activity against a broad range of human cancer cell lines. Nature communications 15 (1) (2024)
Gisele Nishiguchi, Lauren G Mascibroda, Sarah M Young, Elizabeth A Caine, Sherif Abdelhamed, Jeffrey J Kooijman, Darcie J Miller, Sourav Das, Kevin McGowan, Anand Mayasundari, Zhe Shi, Juan M Barajas, Ryan Hiltenbrand, Anup Aggarwal, Yunchao Chang, Vibhor Mishra, Shilpa Narina, Melvin Thomas, Allister J Loughran, Ravi C Kalathur, Kaiwen Yu, Suiping Zhou, Xusheng Wang, Anthony A High, Junmin Peng, Shondra M Pruett-Miller, Danette L Daniels, Marjeta Urh, Anang A Shelat, Charles G Mullighan, Kristin M Riching, Guido J R Zaman, Marcus Fischer, Jeffery M Klco, Zoran Rankovic
Selective CK1α degraders exert antiproliferative activity against a broad range of human cancer cell lines. Nature communications 15 (1) (2024)
Gisele Nishiguchi, Lauren G Mascibroda, Sarah M Young, Elizabeth A Caine, Sherif Abdelhamed, Jeffrey J Kooijman, Darcie J Miller, Sourav Das, Kevin McGowan, Anand Mayasundari, Zhe Shi, Juan M Barajas, Ryan Hiltenbrand, Anup Aggarwal, Yunchao Chang, Vibhor Mishra, Shilpa Narina, Melvin Thomas, Allister J Loughran, Ravi C Kalathur, Kaiwen Yu, Suiping Zhou, Xusheng Wang, Anthony A High, Junmin Peng, Shondra M Pruett-Miller, Danette L Daniels, Marjeta Urh, Anang A Shelat, Charles G Mullighan, Kristin M Riching, Guido J R Zaman, Marcus Fischer, Jeffery M Klco, Zoran Rankovic
Selective CK1α degraders exert antiproliferative activity against a broad range of human cancer cell lines. Nature communications 15 (1) (2024)
Timothy R Stachowski, Marcus Fischer
FLEXR GUI: a graphical user interface for multi-conformer modeling of proteins. Journal of applied crystallography 57 (Pt 2) (2024)
Yunchao Chang, Fatemeh Keramatnia, Pankaj S Ghate, Gisele Nishiguchi, Qingsong Gao, Ilaria Iacobucci, Lei Yang, Divyabharathi Chepyala, Ashutosh Mishra, Anthony Andrew High, Hiroaki Goto, Koshi Akahane, Junmin Peng, Jun J Yang, Marcus Fischer, Zoran Rankovic, Charles G Mullighan
The orally bioavailable GSPT1/2 degrader SJ6986 exhibits in vivo efficacy in acute lymphoblastic leukemia. Blood (2023)
Timothy R Stachowski, Marcus Fischer
FLEXR: automated multi-conformer model building using electron-density map sampling. Acta crystallographica. Section D, Structural biology (2023)
Timothy R Stachowski, Stanley Nithianantham, Murugendra Vanarotti, Karlo Lopez, Marcus Fischer
Pan-Hsp90 ligand binding reveals isoform-specific differences in plasticity and water networks. Protein science : a publication of the Protein Society (2023)
Timothy R Stachowski, Marcus Fischer
Large-Scale Ligand Perturbations of the Protein Conformational Landscape Reveal State-Specific Interaction Hotspots. Journal of medicinal chemistry 65 (20) (2022)
Timothy R Stachowski, Murugendra Vanarotti, Jayaraman Seetharaman, Karlo Lopez, Marcus Fischer
Water Networks Repopulate Protein-Ligand Interfaces with Temperature. Angewandte Chemie (International ed. in English) 61 (31) (2022)
Yunchao Chang, Jaeki Min, Jamie A Jarusiewicz, Marisa Actis, Shanshan Y C Bradford, Anand Mayasundari, Lei Yang, Divyabharathi Chepyala, Lisa J Alcock, Kathryn G Roberts, Stanley Nithianantham, Dylan Maxwell, Lauren Rowland, Randolph Larsen, Aman Seth, Hiroaki Goto, Toshihiko Imamura, Koshi Akahane, Baranda S Hansen, Shondra M Pruett-Miller, Elisabeth M Paietta, Mark R Litzow, Chunxu Qu, Jun J Yang, Marcus Fischer, Zoran Rankovic, Charles G Mullighan
Degradation of Janus kinases in CRLF2-rearranged acute lymphoblastic leukemia. Blood 138 (23) (2022)
Shanshan Y C Bradford, Léa El Khoury, Yunhui Ge, Meghan Osato, David L Mobley, Marcus Fischer
Temperature artifacts in protein structures bias ligand-binding predictions. Chemical science 12 (34) (2021)
Marcus Fischer
Macromolecular room temperature crystallography. Quarterly reviews of biophysics 54 (2021)
Robert A Nicholls, Marcin Wojdyr, Robbie P Joosten, Lucrezia Catapano, Fei Long, Marcus Fischer, Paul Emsley, Garib N Murshudov
The missing link: covalent linkages in structural models. Acta crystallographica. Section D, Structural biology 77 (Pt 6) (2021)
Robert A Nicholls, Robbie P Joosten, Fei Long, Marcin Wojdyr, Andrey A Lebedev, Eugene Krissinel, Lucrezia Catapano, Marcus Fischer, Paul Emsley, Garib N Murshudov
Modelling covalent linkages in CCP4. Acta crystallographica. Section D, Structural biology 77 (Pt 6) (2021)
John F Darby, Adam P Hopkins, Seishi Shimizu, Shirley M Roberts, James A Brannigan, Johan P Turkenburg, Gavin Hugh Thomas, Roderick Eliot Hubbard, Marcus Fischer
Water Networks Can Determine the Affinity of Ligand Binding to Proteins. Journal of the American Chemical Society 141 (40) (2019)
Joshua Pottel, Anat Levit, Magdalena Korczynska, Marcus Fischer, Brian K Shoichet
The Recognition of Unrelated Ligands by Identical Proteins. ACS chemical biology 13 (9) (2018)