Benoît Laleu

Publication Activity (10 Years)

Years Active: 2020-2024
Publications (10 Years): 20

Top Topics

Plasmodium Falciparum

Endoplasmic Reticulum

Top Venues

ACS infectious diseases

Journal of medicinal chemistry

Nature communications

ACS medicinal chemistry letters

This page only lists publications with an associated author ORCID identifier.

Publications

Jingyi Ma, Kimberly Eadie, Marij Schippers, Ahmed Fahal, Benoît Laleu, Annelies Verbon, Wendy van de Sande
Novel Compound MMV1804559 from the Global Health Priority Box Exhibits In Vitro and In Vivo Activity against Madurella mycetomatis . International journal of molecular sciences 25 (11) (2024)
Jingyi Ma, Kimberly Eadie, Marij Schippers, Ahmed Fahal, Benoît Laleu, Annelies Verbon, Wendy van de Sande
Novel Compound MMV1804559 from the Global Health Priority Box Exhibits In Vitro and In Vivo Activity against Madurella mycetomatis . International journal of molecular sciences 25 (11) (2024)
Nicolas Bosc, Eloy Felix, J Mark F Gardner, James E J Mills, Martijn Timmerman, Dennis Asveld, Kim Rensen, Partha Mukherjee, Rishi Das, Elodie Chenu, Dominique Besson, Jeremy N Burrows, James Duffy, Benoît Laleu, Eric M Guantai, Andrew R Leach
MAIP: An Open-Source Tool to Enrich High-Throughput Screening Output and Identify Novel, Druglike Molecules with Antimalarial Activity. ACS medicinal chemistry letters 14 (12) (2023)
Krittikorn Kümpornsin, Theerarat Kochakarn, Tomas Yeo, John Okombo, Madeline R Luth, Johanna Hoshizaki, Mukul Rawat, Richard D Pearson, Kyra A Schindler, Sachel Mok, Heekuk Park, Anne-Catrin Uhlemann, Gouranga P Jana, Bikash C Maity, Benoît Laleu, Elodie Chenu, James Duffy, Sonia Moliner Cubel, Virginia Franco, Maria G Gomez-Lorenzo, Francisco Javier Gamo, Elizabeth A Winzeler, David A Fidock, Thanat Chookajorn, Marcus Chee San Lee
Generation of a mutator parasite to drive resistome discovery in Plasmodium falciparum. Nature communications 14 (1) (2023)
Selina Bopp, Charisse Flerida A Pasaje, Robert L Summers, Pamela Magistrado-Coxen, Kyra A Schindler, Victoriano Corpas-Lopez, Tomas Yeo, Sachel Mok, Sumanta Dey, Sebastian Smick, Armiyaw S Nasamu, Allison R Demas, Rachel Milne, Natalie Wiedemar, Victoria Corey, Maria De Gracia Gomez-Lorenzo, Virginia Franco, Angela M Early, Amanda K Lukens, Danny Milner, Jeremy D Furtado, Francisco-Javier Gamo, Elizabeth A Winzeler, Sarah K Volkman, Maëlle Duffey, Benoît Laleu, David A Fidock, Susan Wyllie, Jacquin C Niles, Dyann F Wirth
Potent acyl-CoA synthetase 10 inhibitors kill Plasmodium falciparum by disrupting triglyceride formation. Nature communications 14 (1) (2023)
Leah S Imlay, Aloysus K Lawong, Suraksha Gahalawat, Ashwani Kumar, Chao Xing, Nimisha Mittal, Sergio Wittlin, Alisje Churchyard, Hanspeter Niederstrasser, Benigno F Crespo-Fernandez, Bruce A Posner, Francisco Javier Gamo, Jake Baum, Elizabeth A Winzeler, Benoît Laleu, Joseph M Ready, Margaret A Phillips
Fast-Killing Tyrosine Amide (( S )-SW228703) with Blood- and Liver-Stage Antimalarial Activity Associated with the Cyclic Amine Resistance Locus ( Pf CARL). ACS infectious diseases 9 (3) (2023)
Nicolas Bosc, Eloy Felix, J Mark F Gardner, James E J Mills, Martijn Timmerman, Dennis Asveld, Kim Rensen, Partha Mukherjee, Rishi Das, Elodie Chenu, Dominique Besson, Jeremy N Burrows, James Duffy, Benoît Laleu, Eric M Guantai, Andrew R Leach
MAIP: An Open-Source Tool to Enrich High-Throughput Screening Output and Identify Novel, Druglike Molecules with Antimalarial Activity. ACS medicinal chemistry letters 14 (12) (2023)
Selina Bopp, Charisse Flerida A Pasaje, Robert L Summers, Pamela Magistrado-Coxen, Kyra A Schindler, Victoriano Corpas-Lopez, Tomas Yeo, Sachel Mok, Sumanta Dey, Sebastian Smick, Armiyaw S Nasamu, Allison R Demas, Rachel Milne, Natalie Wiedemar, Victoria Corey, Maria De Gracia Gomez-Lorenzo, Virginia Franco, Angela M Early, Amanda K Lukens, Danny Milner, Jeremy D Furtado, Francisco-Javier Gamo, Elizabeth A Winzeler, Sarah K Volkman, Maëlle Duffey, Benoît Laleu, David A Fidock, Susan Wyllie, Jacquin C Niles, Dyann F Wirth
Potent acyl-CoA synthetase 10 inhibitors kill Plasmodium falciparum by disrupting triglyceride formation. Nature communications 14 (1) (2023)
Selina Bopp, Charisse Flerida A Pasaje, Robert L Summers, Pamela Magistrado-Coxen, Kyra A Schindler, Victoriano Corpas-Lopez, Tomas Yeo, Sachel Mok, Sumanta Dey, Sebastian Smick, Armiyaw S Nasamu, Allison R Demas, Rachel Milne, Natalie Wiedemar, Victoria Corey, Maria De Gracia Gomez-Lorenzo, Virginia Franco, Angela M Early, Amanda K Lukens, Danny Milner, Jeremy D Furtado, Francisco-Javier Gamo, Elizabeth A Winzeler, Sarah K Volkman, Maëlle Duffey, Benoît Laleu, David A Fidock, Susan Wyllie, Jacquin C Niles, Dyann F Wirth
Potent acyl-CoA synthetase 10 inhibitors kill Plasmodium falciparum by disrupting triglyceride formation. Nature communications 14 (1) (2023)
Leah S Imlay, Aloysus K Lawong, Suraksha Gahalawat, Ashwani Kumar, Chao Xing, Nimisha Mittal, Sergio Wittlin, Alisje Churchyard, Hanspeter Niederstrasser, Benigno F Crespo-Fernandez, Bruce A Posner, Francisco Javier Gamo, Jake Baum, Elizabeth A Winzeler, Benoît Laleu, Joseph M Ready, Margaret A Phillips
Fast-Killing Tyrosine Amide (( S )-SW228703) with Blood- and Liver-Stage Antimalarial Activity Associated with the Cyclic Amine Resistance Locus ( Pf CARL). ACS infectious diseases (2023)
Leah S Imlay, Aloysus K Lawong, Suraksha Gahalawat, Ashwani Kumar, Chao Xing, Nimisha Mittal, Sergio Wittlin, Alisje Churchyard, Hanspeter Niederstrasser, Benigno F Crespo-Fernandez, Bruce A Posner, Francisco Javier Gamo, Jake Baum, Elizabeth A Winzeler, Benoît Laleu, Joseph M Ready, Margaret A Phillips
Fast-Killing Tyrosine Amide (( S )-SW228703) with Blood- and Liver-Stage Antimalarial Activity Associated with the Cyclic Amine Resistance Locus ( Pf CARL). ACS infectious diseases 9 (3) (2023)
Leah S Imlay, Aloysus K Lawong, Suraksha Gahalawat, Ashwani Kumar, Chao Xing, Nimisha Mittal, Sergio Wittlin, Alisje Churchyard, Hanspeter Niederstrasser, Benigno F Crespo-Fernandez, Bruce A Posner, Francisco Javier Gamo, Jake Baum, Elizabeth A Winzeler, Benoît Laleu, Joseph M Ready, Margaret A Phillips
Fast-Killing Tyrosine Amide (( S )-SW228703) with Blood- and Liver-Stage Antimalarial Activity Associated with the Cyclic Amine Resistance Locus ( Pf CARL). ACS infectious diseases 9 (3) (2023)
Nicolas Bosc, Eloy Felix, J Mark F Gardner, James E J Mills, Martijn Timmerman, Dennis Asveld, Kim Rensen, Partha Mukherjee, Rishi Das, Elodie Chenu, Dominique Besson, Jeremy N Burrows, James Duffy, Benoît Laleu, Eric M Guantai, Andrew R Leach
MAIP: An Open-Source Tool to Enrich High-Throughput Screening Output and Identify Novel, Druglike Molecules with Antimalarial Activity. ACS medicinal chemistry letters 14 (12) (2023)
Komei Sakata, Martin A Lowe, Mengyang Xuan, Jeffrey Bruffaerts, Luigi P Stasi, Bénédicte Lallemand, Alvaro Cardenas, Richard D Taylor, Lewis R Vidler, Lloyd King, Jean-Pierre Valentin, Benoît Laleu, Teresa de Haro
Design of Novel Series of Antimalarial PMX Inhibitors with Increased Half-Life via Molecular Property Optimization. ACS medicinal chemistry letters 14 (11) (2023)
Darline Dize, Rolland Bantar Tata, Rodrigue Keumoe, Kouipou Rufin Marie Toghueo, Mariscal Brice Tchatat, Cyrille Ngansop Njanpa, Vianey Claire Tchuenguia, Lauve Tchokouaha Yamthe, Patrick Valere Tsouh Fokou, Benoît Laleu, James Duffy, Ozlem Tastan Bishop, Fabrice Fekam Boyom
Preliminary Structure-Activity Relationship Study of the MMV Pathogen Box Compound MMV675968 (2,4-Diaminoquinazoline) Unveils Novel Inhibitors of Trypanosoma brucei brucei . Molecules (Basel, Switzerland) 27 (19) (2022)
Martin A Lowe, Alvaro Cardenas, Jean-Pierre Valentin, Zhaoning Zhu, Jan Abendroth, Jose L Castro, Reiner Class, Annie Delaunois, Renaud Fleurance, Helga Gerets, Vitalina Gryshkova, Lloyd King, Donald D Lorimer, Malcolm MacCoss, Julian H Rowley, Marie-Luce Rosseels, Leandro Royer, Richard D Taylor, Melanie Wong, Oliver Zaccheo, Vishal P Chavan, Gokul A Ghule, Bapusaheb K Tapkir, Jeremy N Burrows, Maëlle Duffey, Matthias Rottmann, Sergio Wittlin, Iñigo Angulo-Barturen, María Belén Jiménez-Díaz, Josefine Striepen, Kate J Fairhurst, Tomas Yeo, David A Fidock, Alan F Cowman, Paola Favuzza, Benigno Crespo-Fernandez, Francisco Javier Gamo, Daniel E Goldberg, Dominique Soldati-Favre, Benoît Laleu, Teresa de Haro
Discovery and Characterization of Potent, Efficacious, Orally Available Antimalarial Plasmepsin X Inhibitors and Preclinical Safety Assessment of UCB7362 . Journal of medicinal chemistry 65 (20) (2022)
Aloysus Lawong, Suraksha Gahalawat, John Okombo, Josefine Striepen, Tomas Yeo, Sachel Mok, Ioanna Deni, Jessica L Bridgford, Hanspeter Niederstrasser, Anwu Zhou, Bruce Posner, Sergio Wittlin, Francisco Javier Gamo, Benigno Crespo, Alisje Churchyard, Jake Baum, Nimisha Mittal, Elizabeth A Winzeler, Benoît Laleu, Michael J Palmer, Susan A Charman, David A Fidock, Joseph M Ready, Margaret A Phillips
Novel Antimalarial Tetrazoles and Amides Active against the Hemoglobin Degradation Pathway in Plasmodium falciparum. Journal of medicinal chemistry 64 (5) (2021)
Benoît Laleu, Yuichiro Akao, Atsuko Ochida, Sandra Duffy, Leonardo Lucantoni, David M Shackleford, Gong Chen, Kasiram Katneni, Francis C K Chiu, Karen L White, Xue Chen, Angelika Sturm, Koen J Dechering, Benigno Crespo, Laura Maria Sanz, Binglin Wang, Sergio Wittlin, Susan A Charman, Vicky M Avery, Nobuo Cho, Masahiro Kamaura
Discovery and Structure-Activity Relationships of Quinazolinone-2-carboxamide Derivatives as Novel Orally Efficacious Antimalarials. Journal of medicinal chemistry 64 (17) (2021)
Kirandeep Samby, Paul A Willis, Jeremy N Burrows, Benoît Laleu, Peter J H Webborn
Actives from MMV Open Access Boxes? A suggested way forward. PLoS pathogens 17 (4) (2021)
Scott Eagon, Jared T Hammill, Martina Sigal, Kevin J Ahn, Julia E Tryhorn, Grant Koch, Briana Belanger, Cory A Chaplan, Lauren Loop, Anna S Kashtanova, Kenya Yniguez, Horacio Lazaro, Steven P Wilkinson, Amy L Rice, Mofolusho O Falade, Rei Takahashi, Katie Kim, Ashley Cheung, Celine DiBernardo, Joshua J Kimball, Elizabeth A Winzeler, Korina Eribez, Nimisha Mittal, Francisco-Javier Gamo, Benigno Crespo, Alisje Churchyard, Irene García-Barbazán, Jake Baum, Marc O Anderson, Benoît Laleu, R Kiplin Guy
Synthesis and Structure-Activity Relationship of Dual-Stage Antimalarial Pyrazolo[3,4-b]pyridines. Journal of medicinal chemistry 63 (20) (2020)