Francisco Javier Gamo (Francisco-Javier Gamo)

Publication Activity (10 Years)

Years Active: 2020-2023
Publications (10 Years): 25

Top Topics

Plasmodium Falciparum

High Throughput

Top Venues

ACS infectious diseases

Nature communications

Science translational medicine

Journal of medicinal chemistry

This page only lists publications with an associated author ORCID identifier.

Publications

Hao-Chi Hsu, Daqiang Li, Wenhu Zhan, Jianxiang Ye, Yi Jing Liu, Annie Leung, Junling Qin, Benigno Crespo, Francisco Javier Gamo, Hao Zhang, Liwang Cui, Alison Roth, Laura A Kirkman, Huilin Li, Gang Lin
Structures revealing mechanisms of resistance and collateral sensitivity of Plasmodium falciparum to proteasome inhibitors. Nature communications 14 (1) (2023)
Hao-Chi Hsu, Daqiang Li, Wenhu Zhan, Jianxiang Ye, Yi Jing Liu, Annie Leung, Junling Qin, Benigno Crespo, Francisco Javier Gamo, Hao Zhang, Liwang Cui, Alison Roth, Laura A Kirkman, Huilin Li, Gang Lin
Structures revealing mechanisms of resistance and collateral sensitivity of Plasmodium falciparum to proteasome inhibitors. Nature communications 14 (1) (2023)
Krittikorn Kümpornsin, Theerarat Kochakarn, Tomas Yeo, John Okombo, Madeline R Luth, Johanna Hoshizaki, Mukul Rawat, Richard D Pearson, Kyra A Schindler, Sachel Mok, Heekuk Park, Anne-Catrin Uhlemann, Gouranga P Jana, Bikash C Maity, Benoît Laleu, Elodie Chenu, James Duffy, Sonia Moliner Cubel, Virginia Franco, Maria G Gomez-Lorenzo, Francisco Javier Gamo, Elizabeth A Winzeler, David A Fidock, Thanat Chookajorn, Marcus Chee San Lee
Generation of a mutator parasite to drive resistome discovery in Plasmodium falciparum. Nature communications 14 (1) (2023)
Leah S Imlay, Aloysus K Lawong, Suraksha Gahalawat, Ashwani Kumar, Chao Xing, Nimisha Mittal, Sergio Wittlin, Alisje Churchyard, Hanspeter Niederstrasser, Benigno F Crespo-Fernandez, Bruce A Posner, Francisco Javier Gamo, Jake Baum, Elizabeth A Winzeler, Benoît Laleu, Joseph M Ready, Margaret A Phillips
Fast-Killing Tyrosine Amide (( S )-SW228703) with Blood- and Liver-Stage Antimalarial Activity Associated with the Cyclic Amine Resistance Locus ( Pf CARL). ACS infectious diseases 9 (3) (2023)
Eva S Istvan, Francisco M Guerra, Matthew Abraham, Kuo-Sen Huang, Frances Rocamora, Haoshuang Zhao, Lan Xu, Charisse Flerida A Pasaje, Krittikorn Kumpornsin, Madeline R Luth, Haissi Cui, Tuo Yang, Sara Palomo Diaz, Maria G Gomez-Lorenzo, Tarrick Qahash, Nimisha Mittal, Sabine Ottilie, Jacquin C Niles, Marcus Chee San Lee, Manuel Llinás, Nobutaka Kato, John Okombo, David A Fidock, Paul Schimmel, Francisco Javier Gamo, Daniel E Goldberg, Elizabeth A Winzeler
Cytoplasmic isoleucyl tRNA synthetase as an attractive multistage antimalarial drug target. Science translational medicine 15 (686) (2023)
Eva S Istvan, Francisco M Guerra, Matthew Abraham, Kuo-Sen Huang, Frances Rocamora, Haoshuang Zhao, Lan Xu, Charisse Flerida A Pasaje, Krittikorn Kumpornsin, Madeline R Luth, Haissi Cui, Tuo Yang, Sara Palomo Diaz, Maria G Gomez-Lorenzo, Tarrick Qahash, Nimisha Mittal, Sabine Ottilie, Jacquin C Niles, Marcus Chee San Lee, Manuel Llinás, Nobutaka Kato, John Okombo, David A Fidock, Paul Schimmel, Francisco Javier Gamo, Daniel E Goldberg, Elizabeth A Winzeler
Cytoplasmic isoleucyl tRNA synthetase as an attractive multistage antimalarial drug target. Science translational medicine 15 (686) (2023)
Leah S Imlay, Aloysus K Lawong, Suraksha Gahalawat, Ashwani Kumar, Chao Xing, Nimisha Mittal, Sergio Wittlin, Alisje Churchyard, Hanspeter Niederstrasser, Benigno F Crespo-Fernandez, Bruce A Posner, Francisco Javier Gamo, Jake Baum, Elizabeth A Winzeler, Benoît Laleu, Joseph M Ready, Margaret A Phillips
Fast-Killing Tyrosine Amide (( S )-SW228703) with Blood- and Liver-Stage Antimalarial Activity Associated with the Cyclic Amine Resistance Locus ( Pf CARL). ACS infectious diseases (2023)
Mario Carucci, Julien Duez, Joel Tarning, Irene García-Barbazán, Aurélie Fricot-Monsinjon, Abdoulaye Sissoko, Lucie Dumas, Pablo Gamallo, Babette Beher, Pascal Amireault, Michael Dussiot, Ming Dao, Mitchell V Hull, Case W McNamara, Camille Roussel, Papa Alioune Ndour, Laura Maria Sanz, Francisco Javier Gamo, Pierre Buffet
Safe drugs with high potential to block malaria transmission revealed by a spleen-mimetic screening. Nature communications 14 (1) (2023)
Leah S Imlay, Aloysus K Lawong, Suraksha Gahalawat, Ashwani Kumar, Chao Xing, Nimisha Mittal, Sergio Wittlin, Alisje Churchyard, Hanspeter Niederstrasser, Benigno F Crespo-Fernandez, Bruce A Posner, Francisco Javier Gamo, Jake Baum, Elizabeth A Winzeler, Benoît Laleu, Joseph M Ready, Margaret A Phillips
Fast-Killing Tyrosine Amide (( S )-SW228703) with Blood- and Liver-Stage Antimalarial Activity Associated with the Cyclic Amine Resistance Locus ( Pf CARL). ACS infectious diseases 9 (3) (2023)
Hao-Chi Hsu, Daqiang Li, Wenhu Zhan, Jianxiang Ye, Yi Jing Liu, Annie Leung, Junling Qin, Benigno Crespo, Francisco Javier Gamo, Hao Zhang, Liwang Cui, Alison Roth, Laura A Kirkman, Huilin Li, Gang Lin
Structures revealing mechanisms of resistance and collateral sensitivity of Plasmodium falciparum to proteasome inhibitors. Nature communications 14 (1) (2023)
Hao-Chi Hsu, Daqiang Li, Wenhu Zhan, Jianxiang Ye, Yi Jing Liu, Annie Leung, Junling Qin, Benigno Crespo, Francisco Javier Gamo, Hao Zhang, Liwang Cui, Alison Roth, Laura A Kirkman, Huilin Li, Gang Lin
Structures revealing mechanisms of resistance and collateral sensitivity of Plasmodium falciparum to proteasome inhibitors. Nature communications 14 (1) (2023)
Leah S Imlay, Aloysus K Lawong, Suraksha Gahalawat, Ashwani Kumar, Chao Xing, Nimisha Mittal, Sergio Wittlin, Alisje Churchyard, Hanspeter Niederstrasser, Benigno F Crespo-Fernandez, Bruce A Posner, Francisco Javier Gamo, Jake Baum, Elizabeth A Winzeler, Benoît Laleu, Joseph M Ready, Margaret A Phillips
Fast-Killing Tyrosine Amide (( S )-SW228703) with Blood- and Liver-Stage Antimalarial Activity Associated with the Cyclic Amine Resistance Locus ( Pf CARL). ACS infectious diseases 9 (3) (2023)
Eva S Istvan, Francisco M Guerra, Matthew Abraham, Kuo-Sen Huang, Frances Rocamora, Haoshuang Zhao, Lan Xu, Charisse Flerida A Pasaje, Krittikorn Kumpornsin, Madeline R Luth, Haissi Cui, Tuo Yang, Sara Palomo Diaz, Maria G Gomez-Lorenzo, Tarrick Qahash, Nimisha Mittal, Sabine Ottilie, Jacquin C Niles, Marcus Chee San Lee, Manuel Llinás, Nobutaka Kato, John Okombo, David A Fidock, Paul Schimmel, Francisco Javier Gamo, Daniel E Goldberg, Elizabeth A Winzeler
Cytoplasmic isoleucyl tRNA synthetase as an attractive multistage antimalarial drug target. Science translational medicine 15 (686) (2023)
Benjamin R Taft, Fumiaki Yokokawa, Tom Kirrane, Anne-Catherine Mata, Richard Huang, Nicole Blaquiere, Grace Waldron, Bin Zou, Oliver Simon, Subramanyam Vankadara, Wai Ling Chan, Mei Ding, Sandra Sim, Judith Straimer, Armand Guiguemde, Suresh B Lakshminarayana, Jay Prakash Jain, Christophe Bodenreider, Christopher Thompson, Christian Lanshoeft, Wei Shu, Eric Fang, Jafri Qumber, Katherine Chan, Luying Pei, Yen-Liang Chen, Hanna Schulz, Jessie Lim, Siti Nurdiana Abas, Xiaoman Ang, Yugang Liu, Iñigo Angulo-Barturen, María Belén Jiménez-Díaz, Francisco Javier Gamo, Benigno Crespo-Fernandez, Philip J Rosenthal, Roland A Cooper, Patrick Tumwebaze, Anna Caroline Campos Aguiar, Brice Campo, Simon Campbell, Jürgen Wagner, Thierry T Diagana, Christopher Sarko
Discovery and Preclinical Pharmacology of INE963, a Potent and Fast-Acting Blood-Stage Antimalarial with a High Barrier to Resistance and Potential for Single-Dose Cures in Uncomplicated Malaria. Journal of medicinal chemistry 65 (5) (2022)
Martin A Lowe, Alvaro Cardenas, Jean-Pierre Valentin, Zhaoning Zhu, Jan Abendroth, Jose L Castro, Reiner Class, Annie Delaunois, Renaud Fleurance, Helga Gerets, Vitalina Gryshkova, Lloyd King, Donald D Lorimer, Malcolm MacCoss, Julian H Rowley, Marie-Luce Rosseels, Leandro Royer, Richard D Taylor, Melanie Wong, Oliver Zaccheo, Vishal P Chavan, Gokul A Ghule, Bapusaheb K Tapkir, Jeremy N Burrows, Maëlle Duffey, Matthias Rottmann, Sergio Wittlin, Iñigo Angulo-Barturen, María Belén Jiménez-Díaz, Josefine Striepen, Kate J Fairhurst, Tomas Yeo, David A Fidock, Alan F Cowman, Paola Favuzza, Benigno Crespo-Fernandez, Francisco Javier Gamo, Daniel E Goldberg, Dominique Soldati-Favre, Benoît Laleu, Teresa de Haro
Discovery and Characterization of Potent, Efficacious, Orally Available Antimalarial Plasmepsin X Inhibitors and Preclinical Safety Assessment of UCB7362 . Journal of medicinal chemistry 65 (20) (2022)
Wanni Chia, Maria G Gomez-Lorenzo, Isabel Castellote, Jie Xin Tong, Rajesh Chandramohanadas, Trang Thi Thu Chu, Wanxiang Shen, Mei Lin Go, Cristina de Cozar, Benigno Crespo, Maria J Almela, Fernando Neria-Serrano, Virginia Franco, Francisco Javier Gamo, Kevin Shyong-Wei Tan
High-Content Phenotypic Screen of a Focused TCAMS Drug Library Identifies Novel Disruptors of the Malaria Parasite Calcium Dynamics. ACS chemical biology 16 (11) (2021)
Aloysus Lawong, Suraksha Gahalawat, John Okombo, Josefine Striepen, Tomas Yeo, Sachel Mok, Ioanna Deni, Jessica L Bridgford, Hanspeter Niederstrasser, Anwu Zhou, Bruce Posner, Sergio Wittlin, Francisco Javier Gamo, Benigno Crespo, Alisje Churchyard, Jake Baum, Nimisha Mittal, Elizabeth A Winzeler, Benoît Laleu, Michael J Palmer, Susan A Charman, David A Fidock, Joseph M Ready, Margaret A Phillips
Novel Antimalarial Tetrazoles and Amides Active against the Hemoglobin Degradation Pathway in Plasmodium falciparum. Journal of medicinal chemistry 64 (5) (2021)
Lydia Mata-Cantero, Stanley C Xie, Mercedes García, Joanne Coyle, Raquel Fernandez, Alvaro Cortes Cabrera, David L Gillett, Benigno Crespo, Francisco Javier Gamo, Esther Fernandez, Leann Tilley, Maria G Gomez-Lorenzo
High Throughput Screening to Identify Selective and Nonpeptidomimetic Proteasome Inhibitors As Antimalarials. ACS infectious diseases 7 (6) (2021)
Stanley C Xie, Riley D Metcalfe, Hirotake Mizutani, Tanya Puhalovich, Eric Hanssen, Craig J Morton, Yawei Du, Con Dogovski, Shih-Chung Huang, Jeffrey Ciavarri, Paul Hales, Robert J Griffin, Lawrence H Cohen, Bei-Ching Chuang, Sergio Wittlin, Ioanna Deni, Tomas Yeo, Kurt E Ward, Daniel C Barry, Boyin Liu, David L Gillett, Benigno F Crespo-Fernandez, Sabine Ottilie, Nimisha Mittal, Alisje Churchyard, Daniel Ferguson, Anna Caroline Campos Aguiar, Rafael Victorio Carvalho Guido, Jake Baum, Kirsten K Hanson, Elizabeth A Winzeler, Francisco Javier Gamo, David A Fidock, Delphine Baud, Michael W Parker, Stephen Brand, Lawrence R Dick, Michael D W Griffin, Alexandra E Gould, Leann Tilley
Design of proteasome inhibitors with oral efficacy in vivo against Plasmodium falciparum and selectivity over the human proteasome. Proceedings of the National Academy of Sciences of the United States of America 118 (39) (2021)
James M Murithi, Cécile Pascal, Jade Bath, Xavier Boulenc, Nina F Gnädig, Charisse Flerida A Pasaje, Kelly Rubiano, Tomas Yeo, Sachel Mok, Sylvie Klieber, Paul Desert, María Belén Jiménez-Díaz, Jutta Marfurt, Melanie Rouillier, Mohammed H Cherkaoui-Rbati, Nathalie Gobeau, Sergio Wittlin, Anne-Catrin Uhlemann, Richard N Price, Grennady Wirjanata, Rintis Noviyanti, Patrick Tumwebaze, Roland A Cooper, Philip J Rosenthal, Laura M Sanz, Francisco Javier Gamo, Jayan Joseph, Shivendra Singh, Sridevi Bashyam, Jean Michel Augereau, Elie Giraud, Tanguy Bozec, Thierry Vermat, Gilles Tuffal, Jean-Michel Guillon, Jérôme Menegotto, Laurent Sallé, Guillaume Louit, Marie-José Cabanis, Marie Françoise Nicolas, Michel Doubovetzky, Rita Merino, Nadir Bessila, Inigo Angulo-Barturen, Delphine Baud, Lidiya Bebrevska, Fanny Escudie, Jacquin C Niles, Benjamin Blasco, Simon Campbell, Gilles Courtemanche, Laurent Fraisse, Alain Pellet, David A Fidock, Didier Leroy
The antimalarial MMV688533 provides potential for single-dose cures with a high barrier to Plasmodium falciparum parasite resistance. Science translational medicine 13 (603) (2021)
Barbara Forte, Sabine Ottilie, Andrew Plater, Brice Campo, Koen J Dechering, Francisco Javier Gamo, Daniel E Goldberg, Eva S Istvan, Marcus Lee, Amanda K Lukens, Case W MacNamara, Jacquin C Niles, John Okombo, Charisse Flerida A Pasaje, Miles G Siegel, Dyann Wirth, Susan Wyllie, David A Fidock, Beatriz Baragaña, Elizabeth A Winzeler, Ian H Gilbert
Prioritization of Molecular Targets for Antimalarial Drug Discovery. ACS infectious diseases 7 (10) (2021)
Cynthia Tallant, Paul Bamborough, Chun-Wa Chung, Francisco Javier Gamo, Robert Kirkpatrick, Chris Larminie, J Julio Martin, Rab Prinjha, Inmaculada Rioja, Daniel F Simola, Raquel Gabarró, Felix Calderon
Expanding Bromodomain Targeting into Neglected Parasitic Diseases. ACS infectious diseases 7 (11) (2021)
Jorge Emanuel Batista da Rocha, Houcemeddine Othman, Caroline T Tiemessen, Gerrit Botha, Michelle Ramsay, Collen Masimirembwa, Clement A Adebamowo, Ananyo Choudhury, Jean-Tristan Brandenburg, Mogomotsi Matshaba, Gustave Simo, Francisco Javier Gamo, Scott Hazelhurst
G6PD variant distribution in sub-Saharan Africa and potential risks of using chloroquine/hydroxychloroquine based treatments for COVID-19. medRxiv : the preprint server for health sciences (2020)
Mahmood M Alam, Ana Sanchez-Azqueta, Omar Janha, Erika L Flannery, Amit Mahindra, Kopano Mapesa, Aditya B Char, Dev Sriranganadane, Nicolas M B Brancucci, Yevgeniya Antonova-Koch, Kathryn Crouch, Nelson Victor Simwela, Scott B Millar, Jude Akinwale, Deborah Mitcheson, Lev Solyakov, Kate Dudek, Carolyn Jones, Cleofé Zapatero, Christian Doerig, Davis C Nwakanma, Maria Jesús Vázquez, Gonzalo Colmenarejo, Maria Jose Lafuente-Monasterio, Maria Luisa Leon, Paulo H C Godoi, Jonathan M Elkins, Andrew P Waters, Andrew G Jamieson, Elena Fernández Álvaro, Lisa C Ranford-Cartwright, Matthias Marti, Elizabeth A Winzeler, Francisco Javier Gamo, Andrew B Tobin
Validation of the protein kinase PfCLK3 as a multistage cross-species malarial drug target. Science (New York, N.Y.) 365 (6456) (2020)
Rebecca E K Mandt, Maria Jose Lafuente-Monasterio, Tomoyo Sakata-Kato, Madeline R Luth, Delfina Segura-Carro, Alba Pablos-Tanarro, Sara Viera, Noemi Magan, Sabine Ottilie, Elizabeth A Winzeler, Amanda K Lukens, Francisco Javier Gamo, Dyann F Wirth
In vitro selection predicts malaria parasite resistance to dihydroorotate dehydrogenase inhibitors in a mouse infection model. Science translational medicine 11 (521) (2020)