Niraj H Tolia (Niraj Tolia)

ResearcherID ORCID

Publication Activity (10 Years)

Years Active: 2016-2024
Publications (10 Years): 51

Top Venues

Communications biology

Vaccines

NPJ vaccines

Nature communications

National Institutes of Health

Imperial College London (BSC)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

National Institutes of Health May 29 2018

United States

Senior Investigator :: Laboratory of Malaria Immunology and Vaccinology

Washington University in Saint Louis Nov 01 2007 - May 25 2018

United States

Associate Professor :: Molecular Microbiology

Cold Spring Harbor Laboratory Apr 01 2004 - Oct 31 2007

United States

Postdoctoral Fellow

Pfizer Global Research and Development Sandwich Sep 01 1997 - Oct 01 1998

United Kingdom

Industrial Trainee

Education History

Imperial College London Sep 01 1995 - Jun 01 1999

United Kingdom

BSC :: Biochemsitry

Publications

Thayne H Dickey, Holly McAleese, Nichole D Salinas, Lynn E Lambert, Niraj H Tolia
Structure-based design of a Plasmodium vivax Duffy-binding protein immunogen focuses the antibody response to functional epitopes. Protein science : a publication of the Protein Society 33 (8) (2024)
Rui Ma, Nichole D Salinas, Sachy Orr-Gonzalez, Brandi Richardson, Tarik Ouahes, Holly Torano, Bethany J Jenkins, Thayne H Dickey, Jillian Neal, Junhui Duan, Robert D Morrison, Apostolos G Gittis, Justin Y A Doritchamou, Irfan Zaidi, Lynn E Lambert, Patrick E Duffy, Niraj H Tolia
Structure-guided design of VAR2CSA-based immunogens and a cocktail strategy for a placental malaria vaccine. PLoS pathogens 20 (3) (2024)
Nichole D Salinas, Rui Ma, Holly McAleese, Tarik Ouahes, Carole A Long, Kazutoyo Miura, Lynn E Lambert, Niraj H Tolia
A Self-Assembling Pfs230D1-Ferritin Nanoparticle Vaccine Has Potent and Durable Malaria Transmission-Reducing Activity. Vaccines 12 (5) (2024)
Nichole D Salinas, Rui Ma, Holly McAleese, Tarik Ouahes, Carole A Long, Kazutoyo Miura, Lynn E Lambert, Niraj H Tolia
A Self-Assembling Pfs230D1-Ferritin Nanoparticle Vaccine Has Potent and Durable Malaria Transmission-Reducing Activity. Vaccines 12 (5) (2024)
Rui Ma, Nichole D Salinas, Sachy Orr-Gonzalez, Brandi Richardson, Tarik Ouahes, Holly Torano, Bethany J Jenkins, Thayne H Dickey, Jillian Neal, Junhui Duan, Robert D Morrison, Apostolos G Gittis, Justin Y A Doritchamou, Irfan Zaidi, Lynn E Lambert, Patrick E Duffy, Niraj H Tolia
Structure-guided design of VAR2CSA-based immunogens and a cocktail strategy for a placental malaria vaccine. PLoS pathogens 20 (3) (2024)
Rui Ma, Nichole D Salinas, Sachy Orr-Gonzalez, Brandi Richardson, Tarik Ouahes, Holly Torano, Bethany J Jenkins, Thayne H Dickey, Jillian Neal, Junhui Duan, Robert D Morrison, Apostolos G Gittis, Justin Y A Doritchamou, Irfan Zaidi, Lynn E Lambert, Patrick E Duffy, Niraj H Tolia
Structure-guided design of VAR2CSA-based immunogens and a cocktail strategy for a placental malaria vaccine. PLoS pathogens 20 (3) (2024)
Wai Kwan Tang, Nichole D Salinas, Surendra Kumar Kolli, Shulin Xu, Darya V Urusova, Hirdesh Kumar, John R Jimah, Pradeep Annamalai Subramani, Madison M Ogbondah, Samantha J Barnes, John H Adams, Niraj H Tolia
Multistage protective anti-CelTOS monoclonal antibodies with cross-species sterile protection against malaria. Nature communications 15 (1) (2024)
Kevin S Blake, Hirdesh Kumar, Anisha Loganathan, Emily E Williford, Luke Diorio-Toth, Yao-Peng Xue, Wai Kwan Tang, Tayte P Campbell, David D Chong, Steven Angtuaco, Timothy A Wencewicz, Niraj H Tolia, Gautam Dantas
Sequence-structure-function characterization of the emerging tetracycline destructase family of antibiotic resistance enzymes. Communications biology 7 (1) (2024)
Thayne H Dickey, Holly McAleese, Nichole D Salinas, Lynn E Lambert, Niraj H Tolia
Structure-based design of a Plasmodium vivax Duffy-binding protein immunogen focuses the antibody response to functional epitopes. Protein science : a publication of the Protein Society 33 (8) (2024)
Thayne H Dickey, Holly McAleese, Nichole D Salinas, Lynn E Lambert, Niraj H Tolia
Structure-based design of a Plasmodium vivax Duffy-binding protein immunogen focuses the antibody response to functional epitopes. Protein science : a publication of the Protein Society 33 (8) (2024)
Kevin S Blake, Hirdesh Kumar, Anisha Loganathan, Emily E Williford, Luke Diorio-Toth, Yao-Peng Xue, Wai Kwan Tang, Tayte P Campbell, David D Chong, Steven Angtuaco, Timothy A Wencewicz, Niraj H Tolia, Gautam Dantas
Sequence-structure-function characterization of the emerging tetracycline destructase family of antibiotic resistance enzymes. Communications biology 7 (1) (2024)
Kevin S Blake, Hirdesh Kumar, Anisha Loganathan, Emily E Williford, Luke Diorio-Toth, Yao-Peng Xue, Wai Kwan Tang, Tayte P Campbell, David D Chong, Steven Angtuaco, Timothy A Wencewicz, Niraj H Tolia, Gautam Dantas
Sequence-structure-function characterization of the emerging tetracycline destructase family of antibiotic resistance enzymes. Communications biology 7 (1) (2024)
Rui Ma, Nichole D Salinas, Sachy Orr-Gonzalez, Brandi Richardson, Tarik Ouahes, Holly Torano, Bethany J Jenkins, Thayne H Dickey, Jillian Neal, Junhui Duan, Robert D Morrison, Apostolos G Gittis, Justin Y A Doritchamou, Irfan Zaidi, Lynn E Lambert, Patrick E Duffy, Niraj H Tolia
Structure-guided design of VAR2CSA-based immunogens and a cocktail strategy for a placental malaria vaccine. PLoS pathogens 20 (3) (2024)
Palak N Patel, Thayne H Dickey, Ababacar Diouf, Nichole D Salinas, Holly McAleese, Tarik Ouahes, Carole A Long, Kazutoyo Miura, Lynn E Lambert, Niraj H Tolia
Structure-based design of a strain transcending AMA1-RON2L malaria vaccine. Nature communications 14 (1) (2023)
Zhantong Wang, Baoshan Zhang, Li Ou, Qi Qiu, Lingshu Wang, Tatsiana Bylund, Wing-Pui Kong, Wei Shi, Yaroslav Tsybovsky, Lingyuan Wu, Qiong Zhou, Ridhi Chaudhary, Misook Choe, Thayne H Dickey, Mohammed El Anbari, Adam S Olia, Reda Rawi, I-Ting Teng, Danyi Wang, Shuishu Wang, Niraj H Tolia, Tongqing Zhou, Peter D Kwong
Extraordinary Titer and Broad Anti-SARS-CoV-2 Neutralization Induced by Stabilized RBD Nanoparticles from Strain BA.5. Vaccines 12 (1) (2023)
Barbara Baro, Chi Yong Kim, Carrie Lin, Angel K Kongsomboonvech, Marilou Tetard, Nana Ansuah Peterson, Nichole D Salinas, Niraj H Tolia, Elizabeth S Egan
Plasmodium falciparum exploits CD44 as a co-receptor for erythrocyte invasion. Blood (2023)
Hirdesh Kumar, Emily E Williford, Kevin S Blake, Brett Virgin-Downey, Gautam Dantas, Timothy A Wencewicz, Niraj H Tolia
Publisher Correction: Structure of anhydrotetracycline-bound Tet(X6) reveals the mechanism for inhibition of type 1 tetracycline destructases. Communications biology 6 (1) (2023)
Thayne H Dickey, Richi Gupta, Holly McAleese, Tarik Ouahes, Sachy Orr-Gonzalez, Rui Ma, Olga Muratova, Nichole D Salinas, Jen C C Hume, Lynn E Lambert, Patrick Emmet Duffy, Niraj H Tolia
Design of a stabilized non-glycosylated Pfs48/45 antigen enables a potent malaria transmission-blocking nanoparticle vaccine. NPJ vaccines 8 (1) (2023)
Nichole D Salinas, Rui Ma, Thayne H Dickey, Holly McAleese, Tarik Ouahes, Carole A Long, Kazutoyo Miura, Lynn E Lambert, Niraj H Tolia
A potent and durable malaria transmission-blocking vaccine designed from a single-component 60-copy Pfs230D1 nanoparticle. NPJ vaccines 8 (1) (2023)
Barbara Baro-Sastre, Chi Yong Kim, Carrie Lin, Angel K Kongsomboonvech, Marilou Tetard, Nichole D Salinas, Niraj H Tolia, Elizabeth S Egan
Plasmodium falciparum exploits CD44 as a co-receptor for erythrocyte invasion. bioRxiv : the preprint server for biology (2023)
Niharika Shukla, Wai Kwan Tang, Camila Henriques Coelho, Carole A Long, Sara Anne Healy, Issaka Sagara, Kazutoyo Miura, Patrick Emmet Duffy, Niraj H Tolia
A human antibody epitope map of the malaria vaccine antigen Pfs25. NPJ vaccines 8 (1) (2023)
Emily E Williford, Caitlin M DeAngelo, Kevin S Blake, Hirdesh Kumar, Kendrick K Lam, Katherine V Jones, Niraj H Tolia, Gautam Dantas, Timothy A Wencewicz
Structure-Based Design of Bisubstrate Tetracycline Destructase Inhibitors That Block Flavin Redox Cycling. Journal of medicinal chemistry (2023)
Thayne H Dickey, Richi Gupta, Holly McAleese, Tarik Ouahes, Sachy Orr-Gonzalez, Rui Ma, Olga Muratova, Nichole D Salinas, Jen C C Hume, Lynn E Lambert, Patrick Emmet Duffy, Niraj H Tolia
Design of a stabilized non-glycosylated Pfs48/45 antigen enables a potent malaria transmission-blocking nanoparticle vaccine. NPJ vaccines 8 (1) (2023)
Emily E Williford, Caitlin M DeAngelo, Kevin S Blake, Hirdesh Kumar, Kendrick K Lam, Katherine V Jones, Niraj H Tolia, Gautam Dantas, Timothy A Wencewicz
Structure-Based Design of Bisubstrate Tetracycline Destructase Inhibitors That Block Flavin Redox Cycling. Journal of medicinal chemistry 66 (6) (2023)
Zhantong Wang, Baoshan Zhang, Li Ou, Qi Qiu, Lingshu Wang, Tatsiana Bylund, Wing-Pui Kong, Wei Shi, Yaroslav Tsybovsky, Lingyuan Wu, Qiong Zhou, Ridhi Chaudhary, Misook Choe, Thayne H Dickey, Mohammed El Anbari, Adam S Olia, Reda Rawi, I-Ting Teng, Danyi Wang, Shuishu Wang, Niraj H Tolia, Tongqing Zhou, Peter D Kwong
Extraordinary Titer and Broad Anti-SARS-CoV-2 Neutralization Induced by Stabilized RBD Nanoparticles from Strain BA.5. Vaccines 12 (1) (2023)
Hirdesh Kumar, Emily E Williford, Kevin S Blake, Brett Virgin-Downey, Gautam Dantas, Timothy A Wencewicz, Niraj H Tolia
Structure of anhydrotetracycline-bound Tet(X6) reveals the mechanism for inhibition of type 1 tetracycline destructases. Communications biology 6 (1) (2023)
Barbara Baro-Sastre, Chi Yong Kim, Carrie Lin, Angel K Kongsomboonvech, Marilou Tetard, Nichole D Salinas, Niraj H Tolia, Elizabeth S Egan
Plasmodium falciparum exploits CD44 as a co-receptor for erythrocyte invasion. bioRxiv : the preprint server for biology (2023)
Zhantong Wang, Baoshan Zhang, Li Ou, Qi Qiu, Lingshu Wang, Tatsiana Bylund, Wing-Pui Kong, Wei Shi, Yaroslav Tsybovsky, Lingyuan Wu, Qiong Zhou, Ridhi Chaudhary, Misook Choe, Thayne H Dickey, Mohammed El Anbari, Adam S Olia, Reda Rawi, I-Ting Teng, Danyi Wang, Shuishu Wang, Niraj H Tolia, Tongqing Zhou, Peter D Kwong
Extraordinary Titer and Broad Anti-SARS-CoV-2 Neutralization Induced by Stabilized RBD Nanoparticles from Strain BA.5. Vaccines 12 (1) (2023)
Thayne H Dickey, Richi Gupta, Holly McAleese, Tarik Ouahes, Sachy Orr-Gonzalez, Rui Ma, Olga Muratova, Nichole D Salinas, Jen C C Hume, Lynn E Lambert, Patrick Emmet Duffy, Niraj H Tolia
Design of a stabilized non-glycosylated Pfs48/45 antigen enables a potent malaria transmission-blocking nanoparticle vaccine. NPJ vaccines 8 (1) (2023)
Zhantong Wang, Baoshan Zhang, Li Ou, Qi Qiu, Lingshu Wang, Tatsiana Bylund, Wing-Pui Kong, Wei Shi, Yaroslav Tsybovsky, Lingyuan Wu, Qiong Zhou, Ridhi Chaudhary, Misook Choe, Thayne H Dickey, Mohammed El Anbari, Adam S Olia, Reda Rawi, I-Ting Teng, Danyi Wang, Shuishu Wang, Niraj H Tolia, Tongqing Zhou, Peter D Kwong
Extraordinary Titer and Broad Anti-SARS-CoV-2 Neutralization Induced by Stabilized RBD Nanoparticles from Strain BA.5. Vaccines 12 (1) (2023)
Emily E Williford, Caitlin M DeAngelo, Kevin S Blake, Hirdesh Kumar, Kendrick K Lam, Katherine V Jones, Niraj H Tolia, Gautam Dantas, Timothy A Wencewicz
Structure-Based Design of Bisubstrate Tetracycline Destructase Inhibitors That Block Flavin Redox Cycling. Journal of medicinal chemistry 66 (6) (2023)
Barbara Baro-Sastre, Chi Yong Kim, Carrie Lin, Angel K Kongsomboonvech, Marilou Tetard, Nichole D Salinas, Niraj H Tolia, Elizabeth S Egan
Plasmodium falciparum exploits CD44 as a co-receptor for erythrocyte invasion. bioRxiv : the preprint server for biology (2023)
Hirdesh Kumar, Emily E Williford, Kevin S Blake, Brett Virgin-Downey, Gautam Dantas, Timothy A Wencewicz, Niraj H Tolia
Publisher Correction: Structure of anhydrotetracycline-bound Tet(X6) reveals the mechanism for inhibition of type 1 tetracycline destructases. Communications biology 6 (1) (2023)
Camila H Coelho, Wai Kwan Tang, Martin Burkhardt, Jacob D Galson, Olga Muratova, Nichole D Salinas, Thiago Luiz Alves E Silva, Karine Reiter, Nicholas J MacDonald, Vu Nguyen, Raul Herrera, Richard Shimp, David L Narum, Miranda Byrne-Steele, Wenjing Pan, Xiaohong Hou, Brittany Brown, Mary Eisenhower, Jian Han, Bethany J Jenkins, Justin Y A Doritchamou, Margery G Smelkinson, Joel Vega-Rodríguez, Johannes Trück, Justin James Taylor, Issaka Sagara, Sara A Healy, Jonathan P Renn, Niraj H Tolia, Patrick Emmet Duffy
Author Correction: A human monoclonal antibody blocks malaria transmission and defines a highly conserved neutralizing epitope on gametes. Nature communications 13 (1) (2022)
Palak N Patel, Thayne H Dickey, Christine S Hopp, Ababacar Diouf, Wai Kwan Tang, Carole A Long, Kazutoyo Miura, Peter D Crompton, Niraj H Tolia
Neutralizing and interfering human antibodies define the structural and mechanistic basis for antigenic diversion. Nature communications 13 (1) (2022)
Thayne H Dickey, Wai Kwan Tang, Brandi Butler, Tarik Ouahes, Sachy Orr-Gonzalez, Nichole D Salinas, Lynn E Lambert, Niraj H Tolia
Design of the SARS-CoV-2 RBD vaccine antigen improves neutralizing antibody response. Science advances 8 (37) (2022)
Jonathan P Renn, Justin Y A Doritchamou, Bergeline C Nguemwo Tentokam, Robert D Morrison, Matthew V Cowles, Martin Burkhardt, Rui Ma, Almahamoudou Mahamar, Oumar Attaher, Bacary S Diarra, Moussa Traore, Alassane Dicko, Niraj H Tolia, Michal Fried, Patrick Emmet Duffy
Author Correction: Allelic variants of full-length VAR2CSA, the placental malaria vaccine candidate, differ in antigenicity and receptor binding affinity. Communications biology 5 (1) (2022)
Camila H Coelho, Wai Kwan Tang, Martin Burkhardt, Jacob D Galson, Olga Muratova, Nichole D Salinas, Thiago Luiz Alves E Silva, Karine Reiter, Nicholas J MacDonald, Vu Nguyen, Raul Herrera, Richard Shimp, David L Narum, Miranda Byrne-Steele, Wenjing Pan, Xiaohong Hou, Brittany Brown, Mary Eisenhower, Jian Han, Bethany J Jenkins, Justin Y A Doritchamou, Margery G Smelkinson, Joel Vega-Rodríguez, Johannes Trück, Justin James Taylor, Issaka Sagara, Jonathan P Renn, Niraj H Tolia, Patrick Emmet Duffy
A human monoclonal antibody blocks malaria transmission and defines a highly conserved neutralizing epitope on gametes. Nature communications 12 (1) (2021)
Jonathan P Renn, Justin Y A Doritchamou, Bergeline C Nguemwo Tentokam, Robert D Morrison, Matthew V Cowles, Martin Burkhardt, Rui Ma, Niraj H Tolia, Michal Fried, Patrick Emmet Duffy
Allelic variants of full-length VAR2CSA, the placental malaria vaccine candidate, differ in antigenicity and receptor binding affinity. Communications biology 4 (1) (2021)
Brian Nguyen, Niraj H Tolia
Protein-based antigen presentation platforms for nanoparticle vaccines. NPJ vaccines 6 (1) (2021)
Thayne H Dickey, Wai Kwan Tang, Brandi Butler, Tarik Ouahes, Sachy Orr-Gonzalez, Nichole D Salinas, Lynn E Lambert, Niraj H Tolia
Design of the SARS-CoV-2 RBD vaccine antigen improves neutralizing antibody response. bioRxiv : the preprint server for biology (2021)
Rui Ma, Tengfei Lian, Rick Huang, Jonathan P Renn, Jennifer D Petersen, Joshua Zimmerberg, Patrick Emmet Duffy, Niraj H Tolia
Structural basis for placental malaria mediated by Plasmodium falciparum VAR2CSA. Nature microbiology 6 (3) (2021)
Andrew J Gasparrini, Jana L Markley, Hirdesh Kumar, Bin Wang, Luting Fang, Sidra Irum, Chanez T Symister, Meghan Wallace, Carey-Ann D Burnham, Saadia Andleeb, Niraj H Tolia, Timothy A Wencewicz, Gautam Dantas
Tetracycline-inactivating enzymes from environmental, human commensal, and pathogenic bacteria cause broad-spectrum tetracycline resistance. Communications biology 3 (1) (2020)
Hirdesh Kumar, Niraj H Tolia
Getting in: The structural biology of malaria invasion. PLoS pathogens 15 (9) (2019)
Darya Urusova, Lenore Carias, Yining Huang, Vanessa C Nicolete, Jean Popovici, Camille Roesch, Nichole D Salinas, Sebastien Dechavanne, Benoit Witkowski, Marcelo U Ferreira, John H Adams, Michael L Gross, Christopher L King, Niraj H Tolia
Structural basis for neutralization of Plasmodium vivax by naturally acquired human antibodies that target DBP. Nature microbiology 4 (9) (2019)
Nichole D Salinas, May M Paing, Jagat Adhikari, Michael L Gross, Niraj H Tolia
Moderately Neutralizing Epitopes in Nonfunctional Regions Dominate the Antibody Response to Plasmodium falciparum EBA-140. Infection and immunity 87 (4) (2019)
Jian Zhu, Joshua Muia, Garima Gupta, Lisa A Westfield, Karen Vanhoorelbeke, Niraj H Tolia, J Evan Sadler
Exploring the "minimal" structure of a functional ADAMTS13 by mutagenesis and small-angle X-ray scattering. Blood 133 (17) (2019)
Jana L Markley, Luting Fang, Andrew J Gasparrini, Chanez T Symister, Hirdesh Kumar, Niraj H Tolia, Gautam Dantas, Timothy A Wencewicz
Semisynthetic Analogues of Anhydrotetracycline as Inhibitors of Tetracycline Destructase Enzymes. ACS infectious diseases 5 (4) (2019)
May M Paing, Nichole D Salinas, Yvonne Adams, Anna Oksman, Anja Ramstedt Jensen, Daniel E Goldberg, Niraj H Tolia
Shed EBA-175 mediates red blood cell clustering that enhances malaria parasite growth and enables immune evasion. eLife 7 (2018)
Xavier Sisquella, Thomas Nebl, Jennifer K Thompson, Lachlan Whitehead, Brian M Malpede, Nichole D Salinas, Kelly Rogers, Niraj H Tolia, Andrea Fleig, Joseph O'Neill, Wai-Hong Tham, F David Horgen, Alan F Cowman
Plasmodium falciparum ligand binding to erythrocytes induce alterations in deformability essential for invasion. eLife 6 (2017)
John R Jimah, Nichole D Salinas, Monica Sala-Rabanal, Nathaniel G Jones, L David Sibley, Colin G Nichols, Paul H Schlesinger, Niraj H Tolia
Malaria parasite CelTOS targets the inner leaflet of cell membranes for pore-dependent disruption. eLife 5 (2016)

Niraj H Tolia.css-eqlu8i{font-size:small;padding-left:4px;} (Niraj Tolia)

Publication Activity (10 Years)

Top Topics

Top Venues

Niraj H Tolia (Niraj Tolia)