Omer Dushek

ORCID

Publication Activity (10 Years)

Years Active: 2016-2024
Publications (10 Years): 42

Top Venues

Proceedings of the National Academy of Sciences of the United States of America

Nature communications

The EMBO journal

Science advances

University of Oxford

University of British Columbia (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

University of Oxford Jan 01 2018

United Kingdom

Associate Professor, Wellcome Trust Senior Research Fellow :: Sir William Dunn School of Pathology

University of Oxford Sep 01 2012 - Dec 31 2018

United Kingdom

Sir Henry Dale Fellow, University Research Lecturer :: Sir William Dunn School of Pathology

University of Oxford Jan 05 2009 - Aug 31 2012

United Kingdom

Post-doctoral Fellow :: Sir William Dunn School of Pathology

Education History

University of British Columbia Sep 01 2004 - Apr 01 2009

Canada

PHD :: Applied Mathematics

University of Western Ontario Faculty of Science Sep 01 2000 - Apr 01 2004

Canada

BSC :: Physics

Publications

Linnea Z Drexhage, Shengpan Zhang, Maeva Dupont, Franziska Ragaller, Ellen Sjule, Jose Cabezas-Caballero, Lachlan P Deimel, Helen Robertson, Rebecca A Russell, Omer Dushek, Erdinc Sezgin, Niloofar Karaji, Quentin J Sattentau
Apoptosis-mediated ADAM10 activation removes a mucin barrier promoting T cell efferocytosis. Nature communications 15 (1) (2024)
Linnea Z Drexhage, Shengpan Zhang, Maeva Dupont, Franziska Ragaller, Ellen Sjule, Jose Cabezas-Caballero, Lachlan P Deimel, Helen Robertson, Rebecca A Russell, Omer Dushek, Erdinc Sezgin, Niloofar Karaji, Quentin J Sattentau
Apoptosis-mediated ADAM10 activation removes a mucin barrier promoting T cell efferocytosis. Nature communications 15 (1) (2024)
Linnea Z Drexhage, Shengpan Zhang, Maeva Dupont, Franziska Ragaller, Ellen Sjule, Jose Cabezas-Caballero, Lachlan P Deimel, Helen Robertson, Rebecca A Russell, Omer Dushek, Erdinc Sezgin, Niloofar Karaji, Quentin J Sattentau
Apoptosis-mediated ADAM10 activation removes a mucin barrier promoting T cell efferocytosis. Nature communications 15 (1) (2024)
Vanessa Mühlgrabner, Timo Peters, Rubí M-H Velasco Cárdenas, Benjamin Salzer, Janett Göhring, Angelika Plach, Maria Höhrhan, Iago Doel Perez, Vasco Dos Reis Gonçalves, Jesús Siller Farfán, Manfred Lehner, Hannes Stockinger, Wolfgang W A Schamel, Kilian Schober, Dirk H Busch, Michael Hudecek, Omer Dushek, Susana Minguet, René Platzer, Johannes B Huppa
TCR/CD3-based synthetic antigen receptors (TCC) convey superior antigen sensitivity combined with high fidelity of activation. Science advances 10 (36) (2024)
Ashna Patel, Mikhail A Kutuzov, Michael L Dustin, P Anton van der Merwe, Omer Dushek
Regulation of temporal cytokine production by co-stimulation receptors in TCR-T cells is lost in CAR-T cells. Immunotherapy advances 4 (1) (2024)
Vanessa Mühlgrabner, Timo Peters, Rubí M-H Velasco Cárdenas, Benjamin Salzer, Janett Göhring, Angelika Plach, Maria Höhrhan, Iago Doel Perez, Vasco Dos Reis Gonçalves, Jesús Siller Farfán, Manfred Lehner, Hannes Stockinger, Wolfgang W A Schamel, Kilian Schober, Dirk H Busch, Michael Hudecek, Omer Dushek, Susana Minguet, René Platzer, Johannes B Huppa
TCR/CD3-based synthetic antigen receptors (TCC) convey superior antigen sensitivity combined with high fidelity of activation. Science advances 10 (36) (2024)
Linnea Z Drexhage, Shengpan Zhang, Maeva Dupont, Franziska Ragaller, Ellen Sjule, Jose Cabezas-Caballero, Lachlan P Deimel, Helen Robertson, Rebecca A Russell, Omer Dushek, Erdinc Sezgin, Niloofar Karaji, Quentin J Sattentau
Apoptosis-mediated ADAM10 activation removes a mucin barrier promoting T cell efferocytosis. Nature communications 15 (1) (2024)
Ashna Patel, Mikhail A Kutuzov, Michael L Dustin, P Anton van der Merwe, Omer Dushek
Regulation of temporal cytokine production by co-stimulation receptors in TCR-T cells is lost in CAR-T cells. Immunotherapy advances 4 (1) (2024)
Alexandra Mazharian, Ophélie Bertin, Amrita Sarkar, Johanna Augros, Alicia Bornert, Cécile Loubière, Friederike Jönsson, Juli Warwicker, W Mark Abbott, Omer Dushek, Caroline Vayne, Lubica Rauova, Klaus Fütterer, Jerome Rollin, Mortimer Poncz, Yotis A Senis
G6b-B antibody-based cis-acting platelet receptor inhibitors (CAPRIs) as a new family of anti-thrombotic therapeutics. bioRxiv : the preprint server for biology (2024)
Linnea Z Drexhage, Shengpan Zhang, Maeva Dupont, Franziska Ragaller, Ellen Sjule, Jose Cabezas-Caballero, Lachlan P Deimel, Helen Robertson, Rebecca A Russell, Omer Dushek, Erdinc Sezgin, Niloofar Karaji, Quentin J Sattentau
Apoptosis-mediated ADAM10 activation removes a mucin barrier promoting T cell efferocytosis. Nature communications 15 (1) (2024)
Linnea Z Drexhage, Shengpan Zhang, Maeva Dupont, Franziska Ragaller, Ellen Sjule, Jose Cabezas-Caballero, Lachlan P Deimel, Helen Robertson, Rebecca A Russell, Omer Dushek, Erdinc Sezgin, Niloofar Karaji, Quentin J Sattentau
Apoptosis-mediated ADAM10 activation removes a mucin barrier promoting T cell efferocytosis. Nature communications 15 (1) (2024)
Jake Burton, Jesús Siller Farfán, Johannes Pettmann, Benjamin Salzer, Mikhail Kutuzov, Philip Anton van der Merwe, Omer Dushek
Inefficient exploitation of accessory receptors reduces the sensitivity of chimeric antigen receptors. Proceedings of the National Academy of Sciences of the United States of America 120 (2) (2023)
Ashna Patel, Violaine Andre, Sofia Bustamante Eguiguren, Michael I Barton, Jake Burton, Eleanor M Denham, Johannes Pettmann, Alexander M Mørch, Mikhail A Kutuzov, Jesús A Siller-Farfán, Michael L Dustin, Philip Anton van der Merwe, Omer Dushek
Using CombiCells, a platform for titration and combinatorial display of cell surface ligands, to study T-cell antigen sensitivity modulation by accessory receptors. The EMBO journal 43 (1) (2023)
Jake Burton, Jesús Siller Farfán, Johannes Pettmann, Benjamin Salzer, Mikhail Kutuzov, Philip Anton van der Merwe, Omer Dushek
Inefficient exploitation of accessory receptors reduces the sensitivity of chimeric antigen receptors. Proceedings of the National Academy of Sciences of the United States of America 120 (2) (2023)
Jake Burton, Jesús Siller Farfán, Johannes Pettmann, Benjamin Salzer, Mikhail Kutuzov, Philip Anton van der Merwe, Omer Dushek
Inefficient exploitation of accessory receptors reduces the sensitivity of chimeric antigen receptors. Proceedings of the National Academy of Sciences of the United States of America 120 (2) (2023)
Ashna Patel, Violaine Andre, Sofia Bustamante Eguiguren, Michael I Barton, Jake Burton, Eleanor M Denham, Johannes Pettmann, Alexander M Mørch, Mikhail A Kutuzov, Jesús A Siller-Farfán, Michael L Dustin, Philip Anton van der Merwe, Omer Dushek
Using CombiCells, a platform for titration and combinatorial display of cell surface ligands, to study T-cell antigen sensitivity modulation by accessory receptors. The EMBO journal 43 (1) (2023)
Jake Burton, Jesús Siller Farfán, Johannes Pettmann, Benjamin Salzer, Mikhail Kutuzov, Philip Anton van der Merwe, Omer Dushek
Inefficient exploitation of accessory receptors reduces the sensitivity of chimeric antigen receptors. Proceedings of the National Academy of Sciences of the United States of America 120 (2) (2023)
Ashna Patel, Violaine Andre, Sofia Bustamante Eguiguren, Michael I Barton, Jake Burton, Eleanor M Denham, Johannes Pettmann, Alexander M Mørch, Mikhail A Kutuzov, Jesús A Siller-Farfán, Michael L Dustin, Philip Anton van der Merwe, Omer Dushek
Using CombiCells, a platform for titration and combinatorial display of cell surface ligands, to study T-cell antigen sensitivity modulation by accessory receptors. The EMBO journal 43 (1) (2023)
Jake Burton, Jesús Siller Farfán, Johannes Pettmann, Benjamin Salzer, Mikhail Kutuzov, Philip Anton van der Merwe, Omer Dushek
Inefficient exploitation of accessory receptors reduces the sensitivity of chimeric antigen receptors. Proceedings of the National Academy of Sciences of the United States of America 120 (2) (2023)
Jake Burton, Jesús Siller Farfán, Johannes Pettmann, Benjamin Salzer, Mikhail Kutuzov, Philip Anton van der Merwe, Omer Dushek
Inefficient exploitation of accessory receptors reduces the sensitivity of chimeric antigen receptors. Proceedings of the National Academy of Sciences of the United States of America 120 (2) (2023)
Jake Burton, Jesús Siller Farfán, Johannes Pettmann, Benjamin Salzer, Mikhail Kutuzov, Philip Anton van der Merwe, Omer Dushek
Inefficient exploitation of accessory receptors reduces the sensitivity of chimeric antigen receptors. Proceedings of the National Academy of Sciences of the United States of America 120 (2) (2023)
Pablo F Céspedes, Ashwin Jainarayanan, Lola Fernandez-Messina, Salvatore Valvo, David G Saliba, Elke Kurz, Audun Kvalvaag, Lina Chen, Charity Ganskow, Huw Colin-York, Marco Fritzsche, Yanchun Peng, Tao Dong, Errin Johnson, Jesús Siller Farfán, Omer Dushek, Erdinc Sezgin, Ben Peacock, Alice Law, Dimitri Aubert, Simon Engledow, Moustafa Attar, Svenja Hester, Roman Fischer, Francisco Sánchez-Madrid, Michael L Dustin
T-cell trans-synaptic vesicles are distinct and carry greater effector content than constitutive extracellular vesicles. Nature communications 13 (1) (2022)
Johannes Pettmann, Lama Awada, Bartosz Różycki, Anna Huhn, Sara Faour, Mikhail A Kutuzov, Laurent Limozin, Thomas R Weikl, Philip Anton van der Merwe, Philippe Robert, Omer Dushek
Mechanical forces impair antigen discrimination by reducing differences in T-cell receptor/peptide-MHC off-rates. The EMBO journal (2022)
John Nguyen, Johannes Pettmann, Philipp Kruger, Omer Dushek
Quantitative contributions of TNF receptor superfamily members to CD8 + T-cell responses. Molecular systems biology 17 (11) (2022)
Jesse Goyette, David Depoil, Zhengmin Yang, Samuel A Isaacson, Jun Allard, Philip Anton van der Merwe, Katharina Gaus, Michael L Dustin, Omer Dushek
Dephosphorylation accelerates the dissociation of ZAP70 from the T cell receptor. Proceedings of the National Academy of Sciences of the United States of America 119 (9) (2022)
Stuart A MacGowan, Michael I Barton, Mikhail A Kutuzov, Omer Dushek, P Anton van der Merwe, Geoffrey John Barton
Missense variants in human ACE2 strongly affect binding to SARS-CoV-2 Spike providing a mechanism for ACE2 mediated genetic risk in Covid-19: A case study in affinity predictions of interface variants. PLoS computational biology 18 (3) (2022)
Nicola Trendel, Philipp Kruger, Stephanie Gaglione, John Nguyen, Johannes Pettmann, Eduardo D Sontag, Omer Dushek
Perfect adaptation of CD8+ T cell responses to constant antigen input over a wide range of affinities is overcome by costimulation. Science signaling 14 (666) (2021)
Johannes Pettmann, Anna Gesine Huhn, Enas Abu Shah, Mikhail A Kutuzov, Daniel B Wilson, Michael L Dustin, Simon J Davis, Philip Anton van der Merwe, Omer Dushek
The discriminatory power of the T cell receptor. eLife 10 (2021)
Michael I Barton, Stuart A MacGowan, Mikhail A Kutuzov, Omer Dushek, Geoffrey John Barton, Philip Anton van der Merwe
Effects of common mutations in the SARS-CoV-2 Spike RBD and its ligand, the human ACE2 receptor on binding affinity and kinetics. eLife 10 (2021)
Federico Paoletti, Afaf H El-Sagheer, Jun Allard, Tom Brown, Omer Dushek, Fumiko Esashi
Molecular flexibility of DNA as a key determinant of RAD51 recruitment. The EMBO journal 39 (7) (2020)
Benjamin Salzer, Christina M Schueller, Charlotte U Brey, Timo Peters, Michael A Schoeber, Boris Kovacic, Michelle Claudine Buri, Elisabeth Lobner, Omer Dushek, Johannes B Huppa, Christian Obinger, Eva Maria Putz, Wolfgang Holter, Michael W Traxlmayr, Manfred Lehner
Engineering AvidCARs for combinatorial antigen recognition and reversible control of CAR function. Nature communications 11 (1) (2020)
Enas Abu Shah, Nicola Trendel, Philipp Kruger, John Nguyen, Johannes Pettmann, Mikhail Kutuzov, Omer Dushek
Human CD8+ T Cells Exhibit a Shared Antigen Threshold for Different Effector Responses. Journal of immunology (Baltimore, Md. : 1950) 205 (6) (2020)
Laurent Limozin, Marcus J Bridge, Pierre Bongrand, Omer Dushek, Philip Anton van der Merwe, Philippe Robert
TCR-pMHC kinetics under force in a cell-free system show no intrinsic catch bond, but a minimal encounter duration before binding. Proceedings of the National Academy of Sciences of the United States of America 116 (34) (2019)
Jesús Siller Farfán, Omer Dushek
Molecular mechanisms of T cell sensitivity to antigen. Immunological reviews 285 (1) (2019)
Ricardo A Fernandes, Kristina A Ganzinger, Justin C Tzou, Peter Jönsson, Steven F Lee, Matthieu Palayret, Ana Mafalda Santos, Alexander R Carr, Aleks Ponjavic, Veronica T Chang, Charlotte Macleod, B Christoffer Lagerholm, Alan E Lindsay, Omer Dushek, Andreas Tilevik, Simon J Davis, David Klenerman
A cell topography-based mechanism for ligand discrimination by the T cell receptor. Proceedings of the National Academy of Sciences of the United States of America 116 (28) (2019)
Omer Dushek, Michael L Dustin
CD8 helps TCR catch slippery self pMHC. Nature immunology 19 (12) (2019)
Enas Abu Shah, Philippos Demetriou, Štefan Bálint, Viveka Mayya, Mikhail A Kutuzov, Omer Dushek, Michael L Dustin
A tissue-like platform for studying engineered quiescent human T-cells' interactions with dendritic cells. eLife 8 (2019)
Jesse Goyette, Citlali Solis Salas, Nicola Coker-Gordon, Marcus Bridge, Samuel A Isaacson, Jun Allard, Omer Dushek
Biophysical assay for tethered signaling reactions reveals tether-controlled activity for the phosphatase SHP-1. Science advances 3 (3) (2017)
Wei Yang, Weiling Pan, Shuokai Chen, Nicola Trendel, Shutan Jiang, Feng Xiao, Manman Xue, Wei Wu, Zeli Peng, Xiaoxi Li, Hongbin Ji, Xiaolong Liu, Hai Jiang, Haopeng Wang, Hongbin Shen, Omer Dushek, Hua Li, Chenqi Xu
Dynamic regulation of CD28 conformation and signaling by charged lipids and ions. Nature structural & molecular biology 24 (12) (2017)
Daniel T Harris, Marlies V Hager, Sheena N Smith, Qi Cai, Jennifer D Stone, Philipp Kruger, Melissa Lever, Omer Dushek, Thomas M Schmitt, Philip D Greenberg, David M Kranz
Comparison of T Cell Activities Mediated by Human TCRs and CARs That Use the Same Recognition Domains. Journal of immunology (Baltimore, Md. : 1950) 200 (3) (2017)
Abul Azad, Su Yin Lim, Zenobia D'Costa, Keaton Jones, Angela Diana, Owen James Sansom, Philipp Kruger, Stanley Liu, W Gillies McKenna, Omer Dushek, Ruth J Muschel, Emmanouil Fokas
PD-L1 blockade enhances response of pancreatic ductal adenocarcinoma to radiotherapy. EMBO molecular medicine 9 (2) (2017)
Melissa Lever, Hong-Sheng Lim, Philipp Kruger, John Nguyen, Nicola Trendel, Enas Abu-Shah, Philip Kumar Maini, Philip Anton van der Merwe, Omer Dushek
Architecture of a minimal signaling pathway explains the T-cell response to a 1 million-fold variation in antigen affinity and dose. Proceedings of the National Academy of Sciences of the United States of America 113 (43) (2016)

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Publication Activity (10 Years)

Top Topics

Top Venues

Omer Dushek