Hideaki Kakeya

ResearcherID Scopus Author ID Researcher Name Resolver ID ORCID

Publication Activity (10 Years)

Years Active: 2018-2024
Publications (10 Years): 56

Top Venues

The Journal of antibiotics

The Journal of organic chemistry

The Analyst

Organic letters

京都大学 / Kyoto University

Keio University (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

京都大学 / Kyoto University Apr 01 2007

Japan

教授 / Professor :: 薬学研究科 / Graduate Schools of Pharmaceutical Sciences

Kyoto University Apr 01 2007

Japan

Professor :: Graduate School of Pharmaceutical Sciences

RIKEN Institute Apr 01 1994 - Mar 31 2007

Japan

Reseacher/vice-director of Antibitics Lab.

Education History

Keio University - Mar 31 1994

Japan

PHD

Publications

Kensuke Kaneko, Marika Mieda, Yulu Jiang, Nobuaki Takahashi, Hideaki Kakeya
Tumescenamide C, a cyclic lipodepsipeptide from Streptomyces sp. KUSC_F05, exerts antimicrobial activity against the scab-forming actinomycete Streptomyces scabiei. The Journal of antibiotics (2024)
Di Mao, Pengwei Yu, Naoya Shinzato, Lei Zhang, Weiping Zheng, Shan Lu, Hideaki Kakeya
Precezomycin, a novel antibiotic biosynthetic precursor of cezomycin, from actinomycete Kitasatospora putterlickiae 10-13. The Journal of antibiotics 77 (3) (2024)
Shan Lu, Lingling Ren, Di Mao, Hideaki Kakeya
Mechanistic study of the retro-aza-Michael reaction in saccharothriolide L: identification of 2-amino-4-methylphenol as an effective protecting tool for the Michael acceptor. The Journal of antibiotics (2024)
Di Mao, Pengwei Yu, Naoya Shinzato, Lei Zhang, Weiping Zheng, Shan Lu, Hideaki Kakeya
Precezomycin, a novel antibiotic biosynthetic precursor of cezomycin, from actinomycete Kitasatospora putterlickiae 10-13. The Journal of antibiotics 77 (3) (2024)
Shogo Iseki, Hiroaki Ikeda, Sayaka Kobayashi, Kazuhiro Irie, Hiroshi Harada, Hideaki Kakeya
Teleocidin B-4, a PKC Activator, Upregulates Hypoxia-Inducible Factor 1 (HIF-1) Activity by Promoting the Accumulation of HIF-1α Protein via the PKCα/mTORC Signaling Pathway. Journal of natural products 87 (6) (2024)
Di Mao, Pengwei Yu, Naoya Shinzato, Lei Zhang, Weiping Zheng, Shan Lu, Hideaki Kakeya
Precezomycin, a novel antibiotic biosynthetic precursor of cezomycin, from actinomycete Kitasatospora putterlickiae 10-13. The Journal of antibiotics 77 (3) (2024)
Shogo Iseki, Hiroaki Ikeda, Sayaka Kobayashi, Kazuhiro Irie, Hiroshi Harada, Hideaki Kakeya
Teleocidin B-4, a PKC Activator, Upregulates Hypoxia-Inducible Factor 1 (HIF-1) Activity by Promoting the Accumulation of HIF-1α Protein via the PKCα/mTORC Signaling Pathway. Journal of natural products (2024)
Kensuke Kaneko, Marika Mieda, Yulu Jiang, Nobuaki Takahashi, Hideaki Kakeya
Tumescenamide C, a cyclic lipodepsipeptide from Streptomyces sp. KUSC_F05, exerts antimicrobial activity against the scab-forming actinomycete Streptomyces scabiei. The Journal of antibiotics 77 (6) (2024)
Fumihiro Ishikawa, Sho Konno, Hideaki Kakeya, Genzoh Tanabe
Development of a chemical scaffold for inhibiting nonribosomal peptide synthetases in live bacterial cells. Beilstein journal of organic chemistry 20 (2024)
Shan Lu, Lingling Ren, Di Mao, Hideaki Kakeya
Mechanistic study of the retro-aza-Michael reaction in saccharothriolide L: identification of 2-amino-4-methylphenol as an effective protecting tool for the Michael acceptor. The Journal of antibiotics 77 (8) (2024)
Shan Lu, Lingling Ren, Di Mao, Hideaki Kakeya
Mechanistic study of the retro-aza-Michael reaction in saccharothriolide L: identification of 2-amino-4-methylphenol as an effective protecting tool for the Michael acceptor. The Journal of antibiotics 77 (8) (2024)
Fumihiro Ishikawa, Sho Konno, Hideaki Kakeya, Genzoh Tanabe
Development of a chemical scaffold for inhibiting nonribosomal peptide synthetases in live bacterial cells. Beilstein journal of organic chemistry 20 (2024)
Di Mao, Pengwei Yu, Naoya Shinzato, Lei Zhang, Weiping Zheng, Shan Lu, Hideaki Kakeya
Precezomycin, a novel antibiotic biosynthetic precursor of cezomycin, from actinomycete Kitasatospora putterlickiae 10-13. The Journal of antibiotics (2024)
Kensuke Kaneko, Marika Mieda, Yulu Jiang, Nobuaki Takahashi, Hideaki Kakeya
Tumescenamide C, a cyclic lipodepsipeptide from Streptomyces sp. KUSC_F05, exerts antimicrobial activity against the scab-forming actinomycete Streptomyces scabiei. The Journal of antibiotics 77 (6) (2024)
Shogo Iseki, Hiroaki Ikeda, Sayaka Kobayashi, Kazuhiro Irie, Hiroshi Harada, Hideaki Kakeya
Teleocidin B-4, a PKC Activator, Upregulates Hypoxia-Inducible Factor 1 (HIF-1) Activity by Promoting the Accumulation of HIF-1α Protein via the PKCα/mTORC Signaling Pathway. Journal of natural products 87 (6) (2024)
Makoto Ozaki, Motoshi Shimotsuma, Takefumi Kuranaga, Hideaki Kakeya, Tsunehisa Hirose
Separation of amyloid β fragment peptides with racemised and isomerised aspartic acid residues using an original chiral resolution labeling reagent. The Analyst (2023)
Yutaka Furutani, Yoshinori Hirano, Mariko Toguchi, Shoko Higuchi, Xian-Yang Qin, Kaori Yanaka, Yumi Sato-Shiozaki, Nobuaki Takahashi, Marina Sakai, Pornparn Kongpracha, Takehiro Suzuki, Naoshi Dohmae, Mutsuko Kukimoto-Niino, Mikako Shirouzu, Shushi Nagamori, Harukazu Suzuki, Kaoru Kobayashi, Takahiro Masaki, Daisuke Koyama, Kazuma Sekiba, Motoyuki Otsuka, Kazuhiko Koike, Michinori Kohara, Soichi Kojima, Hideaki Kakeya, Tomokazu Matsuura
A small molecule iCDM-34 identified by in silico screening suppresses HBV DNA through activation of aryl hydrocarbon receptor. Cell death discovery 9 (1) (2023)
Makoto Ozaki, Motoshi Shimotsuma, Takefumi Kuranaga, Hideaki Kakeya, Tsunehisa Hirose
Separation of amyloid β fragment peptides with racemised and isomerised aspartic acid residues using an original chiral resolution labeling reagent. The Analyst 148 (6) (2023)
Yutaka Furutani, Yoshinori Hirano, Mariko Toguchi, Shoko Higuchi, Xian-Yang Qin, Kaori Yanaka, Yumi Sato-Shiozaki, Nobuaki Takahashi, Marina Sakai, Pornparn Kongpracha, Takehiro Suzuki, Naoshi Dohmae, Mutsuko Kukimoto-Niino, Mikako Shirouzu, Shushi Nagamori, Harukazu Suzuki, Kaoru Kobayashi, Takahiro Masaki, Daisuke Koyama, Kazuma Sekiba, Motoyuki Otsuka, Kazuhiko Koike, Michinori Kohara, Soichi Kojima, Hideaki Kakeya, Tomokazu Matsuura
A small molecule iCDM-34 identified by in silico screening suppresses HBV DNA through activation of aryl hydrocarbon receptor. Cell death discovery 9 (1) (2023)
Makoto Ozaki, Motoshi Shimotsuma, Takefumi Kuranaga, Hideaki Kakeya, Tsunehisa Hirose
Separation of amyloid β fragment peptides with racemised and isomerised aspartic acid residues using an original chiral resolution labeling reagent. The Analyst 148 (6) (2023)
Toshiki Ochiai, Tensei Inukai, Manato Akiyama, Kairi Furui, Masahito Ohue, Nobuaki Matsumori, Shinsuke Inuki, Motonari Uesugi, Toshiaki Sunazuka, Kazuya Kikuchi, Hideaki Kakeya, Yasubumi Sakakibara
Variational autoencoder-based chemical latent space for large molecular structures with 3D complexity. Communications chemistry 6 (1) (2023)
Takuro Matsuoka, Akira Hattori, Shinya Oishi, Mitsugu Araki, Biao Ma, Toshiki Fujii, Norihito Arichi, Yasushi Okuno, Hideaki Kakeya, Sho Yamasaki, Hiroaki Ohno, Shinsuke Inuki
Establishment of an MR1 Presentation Reporter Screening System and Identification of Phenylpropanoid Derivatives as MR1 Ligands. Journal of medicinal chemistry (2023)
Chengqian Pan, Hiroaki Ikeda, Mayuri Minote, Tensei Tokuda, Takefumi Kuranaga, Tohru Taniguchi, Naoya Shinzato, Hiroyasu Onaka, Hideaki Kakeya
Amoxetamide A, a new anoikis inducer, produced by combined-culture of Amycolatopsis sp. and Tsukamurella pulmonis. The Journal of antibiotics (2023)
Makoto Ozaki, Motoshi Shimotsuma, Takefumi Kuranaga, Hideaki Kakeya, Tsunehisa Hirose
Separation of amyloid β fragment peptides with racemised and isomerised aspartic acid residues using an original chiral resolution labeling reagent. The Analyst 148 (6) (2023)
Makoto Ozaki, Motoshi Shimotsuma, Takefumi Kuranaga, Hideaki Kakeya, Tsunehisa Hirose
Simultaneous separation and identification of all structural isomers and enantiomers of aminobutyric acid using a highly sensitive chiral resolution labeling reagent. Analytical methods : advancing methods and applications (2023)
Takumi Matsumoto, Takefumi Kuranaga, Yuto Taniguchi, Weicheng Wang, Hideaki Kakeya
Solid-phase total synthesis and structural confirmation of antimicrobial longicatenamide A. Beilstein journal of organic chemistry 18 (2022)
Woojoo E Kim, Fumihiro Ishikawa, Rebecca N Re, Takehiro Suzuki, Naoshi Dohmae, Hideaki Kakeya, Genzoh Tanabe, Michael D Burkart
Developing crosslinkers specific for epimerization domain in NRPS initiation modules to evaluate mechanism. RSC chemical biology 3 (3) (2022)
Hiroaki Ikeda, Misato Kawami, Masaya Imoto, Hideaki Kakeya
Identification of the polyether ionophore lenoremycin through a new screening strategy for targeting cancer stem cells. The Journal of antibiotics 75 (12) (2022)
Naoki Kanoh, Yuta Terajima, Suguru Tanaka, Ryusei Terashima, Hiromichi Nishiyama, Shota Nagasawa, Yusuke Sasano, Yoshiharu Iwabuchi, Shinichi Nishimura, Hideaki Kakeya
Toward the Creation of Induced Pluripotent Small (iPS) Molecules: Establishment of a Modular Synthetic Strategy for the Heronamide C-type Polyene Macrolactams and Their Conformational and Reactivity Analysis. The Journal of organic chemistry 86 (23) (2021)
Yulu Jiang, Takumi Matsumoto, Takefumi Kuranaga, Shan Lu, Weicheng Wang, Hiroyasu Onaka, Hideaki Kakeya
Longicatenamides A-D, Two Diastereomeric Pairs of Cyclic Hexapeptides Produced by Combined-culture of Streptomyces sp. KUSC_F05 and Tsukamurella pulmonis TP-B0596. The Journal of antibiotics 74 (5) (2021)
Hiroaki Ikeda, Hideaki Kakeya
Targeting hypoxia-inducible factor 1 (HIF-1) signaling with natural products toward cancer chemotherapy. The Journal of antibiotics 74 (10) (2021)
Chengqian Pan, Takefumi Kuranaga, Xun Cao, Takehiro Suzuki, Naoshi Dohmae, Naoya Shinzato, Hiroyasu Onaka, Hideaki Kakeya
Amycolapeptins A and B, Cyclic Nonadepsipeptides Produced by Combined-culture of Amycolatopsis sp. and Tsukamurella pulmonis. The Journal of organic chemistry 86 (2) (2021)
Takefumi Kuranaga, Miho Tamura, Hiroaki Ikeda, Sakahiro Terada, Yusuke Nakagawa, Hideaki Kakeya
Identification and Total Synthesis of an Unstable Anticancer Macrolide Presaccharothriolide Z Produced by Saccharothrix sp. A1506. Organic letters 23 (18) (2021)
Chao Liu, Junko Hashimoto, Kei Kudo, Kazuo Shin-Ya, Hideaki Kakeya
An Atypical Arginine Dihydrolase Involved in the Biosynthesis of Cyclic Hexapeptide Longicatenamides. Chemistry, an Asian journal 16 (11) (2021)
Naoki Kanoh, Ryusei Terashima, Hiromichi Nishiyama, Yuta Terajima, Shota Nagasawa, Yusuke Sasano, Yoshiharu Iwabuchi, Hiroaki Saito, Syusuke Egoshi, Kosuke Dodo, Mikiko Sodeoka, Chengqian Pan, Yoshinobu Ikeuchi, Shinichi Nishimura, Hideaki Kakeya
Design, Synthesis, and Antifungal Activity of 16,17-Dihydroheronamide C and ent-Heronamide C. The Journal of organic chemistry 86 (23) (2021)
Chengqian Pan, Takefumi Kuranaga, Hideaki Kakeya
Application of the highly sensitive labeling reagent to the structural confirmation of readily isomerizable peptides. Journal of natural medicines 75 (2) (2021)
Kohei Fujita, Misa Ikuta, Shinichi Nishimura, Ryosuke Sugiyama, Aya Yoshimura, Hideaki Kakeya
Amphiol, an Antifungal Fungal Pigment from Pseudogymnoascus sp. PF1464. Journal of natural products 84 (4) (2021)
Hitomi Ozawa-Umeta, Atsuhiro Kishimoto, Atsushi Imaizumi, Tadashi Hashimoto, Tadashi Asakura, Hideaki Kakeya, Masashi Kanai
Curcumin β-D-glucuronide exhibits anti-tumor effects on oxaliplatin-resistant colon cancer with less toxicity in vivo. Cancer science 111 (5) (2020)
Jean-Michel Fustin, Shiqi Ye, Christin Rakers, Kensuke Kaneko, Kazuki Fukumoto, Mayu Yamano, Marijke Versteven, Ellen Grünewald, Samantha J Cargill, T Katherine Tamai, Yao Xu, Maria Luísa Jabbur, Rika Kojima, Melisa L Lamberti, Kumiko Yoshioka-Kobayashi, David Whitmore, Stephanie Tammam, P Lynne Howell, Ryoichiro Kageyama, Takuya Matsuo, Ralf Stanewsky, Diego A Golombek, Carl Hirschie Johnson, Hideaki Kakeya, Gerben van Ooijen, Hitoshi Okamura
Methylation deficiency disrupts biological rhythms from bacteria to humans. Communications biology 3 (1) (2020)
Kosuke Baba, Sara Kuwada, Ayaka Nakao, Xuebing Li, Naoaki Okuda, Ai Nishida, Satoshi Mitsuda, Natsuki Fukuoka, Hideaki Kakeya, Takao Kataoka
Different localization of lysosomal-associated membrane protein 1 (LAMP1) in mammalian cultured cell lines. Histochemistry and cell biology 153 (4) (2020)
Takefumi Kuranaga, Mayuri Minote, Ryota Morimoto, Chengqian Pan, Haruka Ogawa, Hideaki Kakeya
Highly Sensitive Labeling Reagents for Scarce Natural Products. ACS chemical biology 15 (9) (2020)
Takuro Matsuoka, Chihiro Motozono, Akira Hattori, Hideaki Kakeya, Sho Yamasaki, Shinya Oishi, Hiroaki Ohno, Shinsuke Inuki
The effects of 5-OP-RU stereochemistry on its stability and MAIT-MR1 axis. Chembiochem : a European journal of chemical biology 22 (4) (2020)
Akihiko Kanou, Shinichi Nishimura, Toshitsugu Tabuchi, Akihisa Matsuyama, Minoru Yoshida, Taira Kato, Hideaki Kakeya
Serine catabolism produces ROS, sensitizes cells to actin dysfunction, and suppresses cell growth in fission yeast. The Journal of antibiotics 73 (8) (2020)
Chengqian Pan, Takefumi Kuranaga, Chao Liu, Shan Lu, Naoya Shinzato, Hideaki Kakeya
Thioamycolamides A-E, Sulfur-Containing Cycliclipopeptides Produced by the Rare Actinomycete Amycolatopsis sp. Organic letters 22 (8) (2020)
Chao Liu, Hideaki Kakeya
Cryptic Chemical Communication: Secondary Metabolic Responses Revealed by Microbial Co-culture. Chemistry, an Asian journal 15 (3) (2020)
Chengqian Pan, Takefumi Kuranaga, Hideaki Kakeya
Total synthesis of thioamycolamide A via a biomimetic route. Organic & biomolecular chemistry 18 (41) (2020)
Nobuaki Takahashi, Kensuke Kaneko, Hideaki Kakeya
Total Synthesis and Antimicrobial Activity of Tumescenamide C and Its Derivatives. The Journal of organic chemistry 85 (6) (2020)
Jean-Michel Fustin, Shiqi Ye, Christin Rakers, Kensuke Kaneko, Kazuki Fukumoto, Mayu Yamano, Marijke Versteven, Ellen Grünewald, Samantha J Cargill, T Katherine Tamai, Yao Xu, Maria Luísa Jabbur, Rika Kojima, Melisa L Lamberti, Kumiko Yoshioka-Kobayashi, David Whitmore, Stephanie Tammam, P Lynne Howell, Ryoichiro Kageyama, Takuya Matsuo, Ralf Stanewsky, Diego A Golombek, Carl Hirschie Johnson, Hideaki Kakeya, Gerben van Ooijen, Hitoshi Okamura
Publisher Correction: Methylation deficiency disrupts biological rhythms from bacteria to humans. Communications biology 3 (1) (2020)
Kana Shimizu, Yoichi Sunagawa, Masafumi Funamoto, Hiroki Wakabayashi, Mai Genpei, Yusuke Miyazaki, Yasufumi Katanasaka, Nurmila Sari, Satoshi Shimizu, Ayumi Katayama, Hiroyuki Shibata, Yoshiharu Iwabuchi, Hideaki Kakeya, Hiromichi Wada, Koji Hasegawa, Tatsuya Morimoto
The Synthetic Curcumin Analogue GO-Y030 Effectively Suppresses the Development of Pressure Overload-induced Heart Failure in Mice. Scientific reports 10 (1) (2020)
Hiroaki Ikeda, Makoto Muroi, Yasumitsu Kondoh, Shumpei Ishikawa, Hideaki Kakeya, Hiroyuki Osada, Masaya Imoto
Miclxin, a Novel MIC60 Inhibitor, Induces Apoptosis via Mitochondrial Stress in β-Catenin Mutant Tumor Cells. ACS chemical biology 15 (8) (2020)
Ryosuke Sugiyama, Takahiro Nakatani, Shinichi Nishimura, Kei Takenaka, Taro Ozaki, Shumpei Asamizu, Hiroyasu Onaka, Hideaki Kakeya
Chemical Interactions of Cryptic Actinomycete Metabolite 5-Alkyl-1,2,3,4-tetrahydroquinolines through Aggregate Formation. Angewandte Chemie (International ed. in English) 58 (38) (2019)
Yutaka Furutani, Mariko Toguchi, Yumi Shiozaki-Sato, Xian-Yang Qin, Etsuko Ebisui, Shoko Higuchi, Masayuki Sudoh, Harukazu Suzuki, Nobuaki Takahashi, Koichi Watashi, Takaji Wakita, Hideaki Kakeya, Soichi Kojima
An interferon-like small chemical compound CDM-3008 suppresses hepatitis B virus through induction of interferon-stimulated genes. PloS one 14 (6) (2019)
Xuebing Li, Akira Hattori, Senye Takahashi, Yoko Goto, Hiroshi Harada, Hideaki Kakeya
Ubiquitin carboxyl-terminal hydrolase L1 promotes hypoxia-inducible factor 1-dependent tumor cell malignancy in spheroid models. Cancer science 111 (1) (2019)
Nobuaki Takahashi, Hideaki Hayashi, Viktors Poznaks, Hideaki Kakeya
Total synthesis of verucopeptin, an inhibitor of hypoxia-inducible factor 1 (HIF-1). Chemical communications (Cambridge, England) 55 (79) (2019)
Aya Yoshimura, Shinichi Nishimura, Takehiro Suzuki, Akira Hattori, Naoshi Dohmae, Taira Kato, Hideaki Kakeya
Isolation, Structure Elucidation, and Conformational Regulation of Myropeptins, Lipopeptides from the Fungus Myrothecium roridum. Organic letters 21 (18) (2019)
Shan Lu, Shinichi Nishimura, Kei Takenaka, Masashi Ito, Taira Kato, Hideaki Kakeya
Discovery of Presaccharothriolide X, a Retro-Michael Reaction Product of Saccharothriolide B, from the Rare Actinomycete Saccharothrix sp. A1506. Organic letters 20 (15) (2018)

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Publication Activity (10 Years)

Top Topics

Top Venues

Hideaki Kakeya