Petr Broz

ORCID

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 40

Top Venues

The EMBO journal

Archives of toxicology

Nature microbiology

PLoS pathogens

Universite de Lausanne

Universität Basel (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

Universite de Lausanne Oct 01 2017

Switzerland

Associate Professor :: Department of Biochemistry

Universität Basel Department Biozentrum Jan 01 2013 - Oct 01 2017

Switzerland

Assistant Professor :: Infection Biology

Stanford University School of Medicine

United States

Postdoc :: Microbiology and Immunology

CSL Behring AG

Switzerland

Scientist :: R&D

Education History

Universität Basel

Switzerland

PHD :: Biozentrum, Infection Biology

Publications

Kaiwen W Chen, Petr Broz
Gasdermins as evolutionarily conserved executors of inflammation and cell death. Nature cell biology (2024)
Saray Ramos, Ella Hartenian, José Carlos Santos, Philipp Walch, Petr Broz
NINJ1 induces plasma membrane rupture and release of damage-associated molecular pattern molecules during ferroptosis. The EMBO journal 43 (7) (2024)
Julie Sollier, Marek Basler, Petr Broz, Petra S Dittrich, Knut Drescher, Adrian Egli, Alexander Harms, Andreas Hierlemann, Sebastian Hiller, Carolyn G King, John D Mckinney, Jacob Moran-Gilad, Richard A Neher, Malcolm G P Page, Sven Panke, Alexandre Persat, Paola Picotti, Katharina M Rentsch, Pablo Rivera-Fuentes, Uwe Sauer, Daiana Stolz, Sarah Tschudin-Sutter, Christian van Delden, Erik van Nimwegen, Jan-Willem van Groenigen, Mattia Zampieri, Annelies S Zinkernagel, Nina Khanna, Dirk Bumann, Urs Jenal, Christoph Dehio
Revitalizing antibiotic discovery and development through in vitro modelling of in-patient conditions. Nature microbiology 9 (1) (2024)
Saray Ramos, Ella Hartenian, José Carlos Santos, Philipp Walch, Petr Broz
NINJ1 induces plasma membrane rupture and release of damage-associated molecular pattern molecules during ferroptosis. The EMBO journal 43 (7) (2024)
Julie Sollier, Marek Basler, Petr Broz, Petra S Dittrich, Knut Drescher, Adrian Egli, Alexander Harms, Andreas Hierlemann, Sebastian Hiller, Carolyn G King, John D Mckinney, Jacob Moran-Gilad, Richard A Neher, Malcolm G P Page, Sven Panke, Alexandre Persat, Paola Picotti, Katharina M Rentsch, Pablo Rivera-Fuentes, Uwe Sauer, Daiana Stolz, Sarah Tschudin-Sutter, Christian van Delden, Erik van Nimwegen, Jan-Willem van Groenigen, Mattia Zampieri, Annelies S Zinkernagel, Nina Khanna, Dirk Bumann, Urs Jenal, Christoph Dehio
Revitalizing antibiotic discovery and development through in vitro modelling of in-patient conditions. Nature microbiology 9 (1) (2024)
Ella Hartenian, Petr Broz
Pyroptosis: palmitoylation regulates GSDMD activation and pore formation. Cell research (2024)
Saray Ramos, Ella Hartenian, José Carlos Santos, Philipp Walch, Petr Broz
NINJ1 induces plasma membrane rupture and release of damage-associated molecular pattern molecules during ferroptosis. The EMBO journal (2024)
Saray Ramos, Ella Hartenian, José Carlos Santos, Philipp Walch, Petr Broz
NINJ1 induces plasma membrane rupture and release of damage-associated molecular pattern molecules during ferroptosis. The EMBO journal 43 (7) (2024)
Julie Sollier, Marek Basler, Petr Broz, Petra S Dittrich, Knut Drescher, Adrian Egli, Alexander Harms, Andreas Hierlemann, Sebastian Hiller, Carolyn G King, John D Mckinney, Jacob Moran-Gilad, Richard A Neher, Malcolm G P Page, Sven Panke, Alexandre Persat, Paola Picotti, Katharina M Rentsch, Pablo Rivera-Fuentes, Uwe Sauer, Daiana Stolz, Sarah Tschudin-Sutter, Christian van Delden, Erik van Nimwegen, Jan-Willem van Groenigen, Mattia Zampieri, Annelies S Zinkernagel, Nina Khanna, Dirk Bumann, Urs Jenal, Christoph Dehio
Revitalizing antibiotic discovery and development through in vitro modelling of in-patient conditions. Nature microbiology (2024)
Saray Ramos, Ella Hartenian, José Carlos Santos, Philipp Walch, Petr Broz
NINJ1 induces plasma membrane rupture and release of damage-associated molecular pattern molecules during ferroptosis. The EMBO journal 43 (7) (2024)
Riccardo Leinardi, Amandine Pochet, Francine Uwambayinema, Yousof Yakoub, Valerie F J Quesniaux, Bernhard Ryffel, Petr Broz, Cristina Pavan, François Huaux
Gasdermin D membrane pores orchestrate IL-1α secretion from necrotic macrophages after NFS-rich silica exposure. Archives of toxicology 97 (4) (2023)
Morris Degen, José Carlos Santos, Kristyna Pluhackova, Gonzalo Cebrero, Saray Ramos, Gytis Jankevicius, Ella Hartenian, Undina Guillerm, Stefania A Mari, Bastian Kohl, Daniel J Müller, Paul Schanda, Timm Maier, Camilo Perez, Christian Sieben, Petr Broz, Sebastian Hiller
Structural basis of NINJ1-mediated plasma membrane rupture in cell death. Nature (2023)
Stefan Alexander Fattinger, Luca Maurer, Petra Geiser, Elliott M Bernard, Ursina Enz, Suwannee Ganguillet, Ersin Gül, Sanne Kroon, Benjamin Demarco, Vanessa Mack, Markus Furter, Manja Barthel, Pawel Pelczar, Feng Shao, Petr Broz, Mikael Erik Sellin, Wolf-Dietrich Hardt
Gasdermin D is the only Gasdermin that provides protection against acute Salmonella gut infection in mice. Proceedings of the National Academy of Sciences of the United States of America 120 (48) (2023)
Eva Hasel de Carvalho, Shivani S Dharmadhikari, Kateryna Shkarina, Jingwei Rachel Xiong, Bruno Reversade, Petr Broz, Maria Leptin
The Opto-inflammasome in zebrafish as a tool to study cell and tissue responses to speck formation and cell death. eLife 12 (2023)
Riccardo Leinardi, Amandine Pochet, Francine Uwambayinema, Yousof Yakoub, Valerie F J Quesniaux, Bernhard Ryffel, Petr Broz, Cristina Pavan, François Huaux
Gasdermin D membrane pores orchestrate IL-1α secretion from necrotic macrophages after NFS-rich silica exposure. Archives of toxicology (2023)
Riccardo Leinardi, Amandine Pochet, Francine Uwambayinema, Yousof Yakoub, Valerie F J Quesniaux, Bernhard Ryffel, Petr Broz, Cristina Pavan, François Huaux
Gasdermin D membrane pores orchestrate IL-1α secretion from necrotic macrophages after NFS-rich silica exposure. Archives of toxicology 97 (4) (2023)
Riccardo Leinardi, Amandine Pochet, Francine Uwambayinema, Yousof Yakoub, Valerie F J Quesniaux, Bernhard Ryffel, Petr Broz, Cristina Pavan, François Huaux
Gasdermin D membrane pores orchestrate IL-1α secretion from necrotic macrophages after NFS-rich silica exposure. Archives of toxicology 97 (4) (2023)
Riccardo Leinardi, Amandine Pochet, Francine Uwambayinema, Yousof Yakoub, Valerie F J Quesniaux, Bernhard Ryffel, Petr Broz, Cristina Pavan, François Huaux
Gasdermin D membrane pores orchestrate IL-1α secretion from necrotic macrophages after NFS-rich silica exposure. Archives of toxicology 97 (4) (2023)
Monika Pruenster, Roland Immler, Jonas Roth, Timon Kuchler, Thomas Bromberger, Matteo Napoli, Katrin Nussbaumer, Ina Rohwedder, Lou Martha Wackerbarth, Chiara Piantoni, Konstantin Hennis, Diana Fink, Sebastian Kallabis, Tobias Schroll, Sergi Masgrau-Alsina, Agnes Budke, Wang Liu, Dietmar Vestweber, Christian Wahl-Schott, Johannes Roth, Rüdiger Klein, Markus Moser, Thomas Vogl, Veit Hornung, Petr Broz, Markus Sperandio
E-selectin-mediated rapid NLRP3 inflammasome activation regulates S100A8/S100A9 release from neutrophils via transient gasdermin D pore formation. Nature immunology (2023)
Elliott M Bernard, Petr Broz
Activation and manipulation of inflammasomes and pyroptosis during bacterial infections. The Biochemical journal 479 (7) (2022)
Ella Hartenian, Petr Broz
Viral protein activates the NLRP1 inflammasome. Nature immunology 23 (6) (2022)
Kateryna Shkarina, Eva Hasel de Carvalho, José Carlos Santos, Saray Ramos, Maria Leptin, Petr Broz
Optogenetic activators of apoptosis, necroptosis, and pyroptosis. The Journal of cell biology 221 (6) (2022)
Elisabet Bjanes, Reyna Garcia Sillas, Rina Matsuda, Benjamin Demarco, Timothée Fettrelet, Alexandra A DeLaney, Opher S Kornfeld, Bettina L Lee, Eric M Rodríguez López, Daniel Grubaugh, Meghan A Wynosky-Dolfi, Naomi H Philip, Elise Krespan, Dorothy Tovar, Leonel Joannas, Daniel P Beiting, Jorge Henao-Mejia, Brian C Schaefer, Kaiwen W Chen, Petr Broz, Igor E Brodsky
Genetic targeting of Card19 is linked to disrupted NINJ1 expression, impaired cell lysis, and increased susceptibility to Yersinia infection. PLoS pathogens 17 (10) (2021)
Kaiwen W Chen, Benjamin Demarco, Saray Ramos, Rosalie Heilig, Michiel Goris, James P Grayczyk, Charles-Antoine Assenmacher, Enrico Radaelli, Leonel D Joannas, Jorge Henao-Mejia, Fabienne Tacchini-Cottier, Igor E Brodsky, Petr Broz
RIPK1 activates distinct gasdermins in macrophages and neutrophils upon pathogen blockade of innate immune signaling. Proceedings of the National Academy of Sciences of the United States of America 118 (28) (2021)
Rosalie Heilig, Marisa Dilucca, Dave Boucher, Kaiwen W Chen, Dora Hancz, Benjamin Demarco, Kateryna Shkarina, Petr Broz
Caspase-1 cleaves Bid to release mitochondrial SMAC and drive secondary necrosis in the absence of GSDMD. Life science alliance 3 (6) (2020)
José Carlos Santos, Dave Boucher, Larisa Kapinos Schneider, Benjamin Demarco, Marisa Dilucca, Kateryna Shkarina, Rosalie Heilig, Kaiwen W Chen, Roderick Y H Lim, Petr Broz
Human GBP1 binds LPS to initiate assembly of a caspase-4 activating platform on cytosolic bacteria. Nature communications 11 (1) (2020)
Benjamin Demarco, James P Grayczyk, Elisabet Bjanes, Didier Le Roy, Wulf Tonnus, Charles-Antoine Assenmacher, Enrico Radaelli, Timothée Fettrelet, Vanessa Mack, Andreas Linkermann, Thierry Roger, Igor E Brodsky, Kaiwen W Chen, Petr Broz
Caspase-8-dependent gasdermin D cleavage promotes antimicrobial defense but confers susceptibility to TNF-induced lethality. Science advances 6 (47) (2020)
Benjamin Demarco, Kaiwen W Chen, Petr Broz
Cross talk between intracellular pathogens and cell death. Immunological reviews 297 (1) (2020)
Kaiwen W Chen, Benjamin Demarco, Petr Broz
Beyond inflammasomes: emerging function of gasdermins during apoptosis and NETosis. The EMBO journal 39 (2) (2019)
Kaiwen W Chen, Benjamin Demarco, Rosalie Heilig, Kateryna Shkarina, Andreas Boettcher, Christopher J Farady, Pawel Pelczar, Petr Broz
Extrinsic and intrinsic apoptosis activate pannexin-1 to drive NLRP3 inflammasome assembly. The EMBO journal 38 (10) (2019)
Kaiwen W Chen, Benjamin Demarco, Petr Broz
Pannexin-1 promotes NLRP3 activation during apoptosis but is dispensable for canonical or noncanonical inflammasome activation. European journal of immunology 50 (2) (2019)
Benjamin Demarco, Kaiwen W Chen, Petr Broz
Pannexin-1 channels bridge apoptosis to NLRP3 inflammasome activation. Molecular & cellular oncology 6 (4) (2019)
Kaiwen W Chen, Mercedes M Monteleone, Dave Boucher, Gabriel Sollberger, Divya Ramnath, Nicholas D Condon, Jessica B von Pein, Petr Broz, Matthew J Sweet, Kate Schroder
Noncanonical inflammasome signaling elicits gasdermin D-dependent neutrophil extracellular traps. Science immunology 3 (26) (2019)
Petr Broz, Pablo Pelegrin, Feng Shao
The gasdermins, a protein family executing cell death and inflammation. Nature reviews. Immunology 20 (3) (2019)
Sebastian Rühl, Kateryna Shkarina, Benjamin Demarco, Rosalie Heilig, José Carlos Santos, Petr Broz
ESCRT-dependent membrane repair negatively regulates pyroptosis downstream of GSDMD activation. Science (New York, N.Y.) 362 (6417) (2019)
José Carlos Santos, Mathias S Dick, Brice Lagrange, Daniel Degrandi, Klaus Pfeffer, Masahiro Yamamoto, Etienne Meunier, Pawel Pelczar, Thomas Henry, Petr Broz
LPS targets host guanylate-binding proteins to the bacterial outer membrane for non-canonical inflammasome activation. The EMBO journal 37 (6) (2018)
Daiane M Cerqueira, Marco Túlio R Gomes, Alexandre L N Silva, Marcella Rungue, Natan R G Assis, Erika S Guimarães, Suellen B Morais, Petr Broz, Dario S Zamboni, Sergio Costa Oliveira
Guanylate-binding protein 5 licenses caspase-11 for Gasdermin-D mediated host resistance to Brucella abortus infection. PLoS pathogens 14 (12) (2018)
Rosalie Heilig, Mathias S Dick, Lorenzo Sborgi, Etienne Meunier, Sebastian Hiller, Petr Broz
The Gasdermin-D pore acts as a conduit for IL-1β secretion in mice. European journal of immunology 48 (4) (2018)
Pierre Wallet, Sacha Benaoudia, Amandine Mosnier, Brice Lagrange, Amandine Martin, Helena Lindgren, Igor Golovliov, Fanny Michal, Pauline Basso, Sophia Djebali, Angelina Provost, Omran Allatif, Etienne Meunier, Petr Broz, Masahiro Yamamoto, Bénédicte F Py, Eric Faudry, Anders Sjöstedt, Thomas Henry
IFN-γ extends the immune functions of Guanylate Binding Proteins to inflammasome-independent antibacterial activities during Francisella novicida infection. PLoS pathogens 13 (10) (2017)
Rosalie Heilig, Petr Broz
Function and mechanism of the pyrin inflammasome. European journal of immunology 48 (2) (2017)

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Publication Activity (10 Years)

Top Topics

Top Venues

Petr Broz