Robert I Horne

Publication Activity (10 Years)

Years Active: 2020-2024
Publications (10 Years): 23

Top Topics

Acute Myeloid Leukemia

Structural Basis

Machine Learning

Top Venues

Journal of chemical information and modeling

Journal of chemical theory and computation

Nature chemical biology

Communications chemistry

This page only lists publications with an associated author ORCID identifier.

Publications

Robert I Horne, Ewa A Andrzejewska, Parvez Alam, Z Faidon Brotzakis, Ankit Srivastava, Alice Aubert, Magdalena Nowinska, Rebecca C Gregory, Roxine Staats, Andrea Possenti, Sean Chia, Pietro Sormanni, Bernardino Ghetti, Byron Caughey, Tuomas P J Knowles, Christopher M Dobson
Discovery of potent inhibitors of α-synuclein aggregation using structure-based iterative learning. Nature chemical biology 20 (5) (2024)
Robert I Horne, Jared Wilson-Godber, Alicia González Díaz, Z Faidon Brotzakis, Srijit Seal, Rebecca C Gregory, Andrea Possenti, Sean Chia, Christopher M Dobson
Using Generative Modeling to Endow with Potency Initially Inert Compounds with Good Bioavailability and Low Toxicity. Journal of chemical information and modeling 64 (3) (2024)
Robert I Horne, Ewa A Andrzejewska, Parvez Alam, Z Faidon Brotzakis, Ankit Srivastava, Alice Aubert, Magdalena Nowinska, Rebecca C Gregory, Roxine Staats, Andrea Possenti, Sean Chia, Pietro Sormanni, Bernardino Ghetti, Byron Caughey, Tuomas P J Knowles, Christopher M Dobson
Discovery of potent inhibitors of α-synuclein aggregation using structure-based iterative learning. Nature chemical biology 20 (5) (2024)
Robert I Horne, Ewa A Andrzejewska, Parvez Alam, Z Faidon Brotzakis, Ankit Srivastava, Alice Aubert, Magdalena Nowinska, Rebecca C Gregory, Roxine Staats, Andrea Possenti, Sean Chia, Pietro Sormanni, Bernardino Ghetti, Byron Caughey, Tuomas P J Knowles, Christopher M Dobson
Discovery of potent inhibitors of α-synuclein aggregation using structure-based iterative learning. Nature chemical biology 20 (5) (2024)
Robert I Horne, Jared Wilson-Godber, Alicia González Díaz, Z Faidon Brotzakis, Srijit Seal, Rebecca C Gregory, Andrea Possenti, Sean Chia, Christopher M Dobson
Using Generative Modeling to Endow with Potency Initially Inert Compounds with Good Bioavailability and Low Toxicity. Journal of chemical information and modeling 64 (3) (2024)
Robert I Horne, Jared Wilson-Godber, Alicia González Díaz, Z Faidon Brotzakis, Srijit Seal, Rebecca C Gregory, Andrea Possenti, Sean Chia, Christopher M Dobson
Using Generative Modeling to Endow with Potency Initially Inert Compounds with Good Bioavailability and Low Toxicity. Journal of chemical information and modeling (2024)
Robert I Horne, Jared Wilson-Godber, Alicia González Díaz, Z Faidon Brotzakis, Srijit Seal, Rebecca C Gregory, Andrea Possenti, Sean Chia, Christopher M Dobson
Using Generative Modeling to Endow with Potency Initially Inert Compounds with Good Bioavailability and Low Toxicity. Journal of chemical information and modeling 64 (3) (2024)
Robert I Horne, Jared Wilson-Godber, Alicia González Díaz, Z Faidon Brotzakis, Srijit Seal, Rebecca C Gregory, Andrea Possenti, Sean Chia, Christopher M Dobson
Using Generative Modeling to Endow with Potency Initially Inert Compounds with Good Bioavailability and Low Toxicity. Journal of chemical information and modeling 64 (3) (2024)
Robert I Horne, Ewa A Andrzejewska, Parvez Alam, Z Faidon Brotzakis, Ankit Srivastava, Alice Aubert, Magdalena Nowinska, Rebecca C Gregory, Roxine Staats, Andrea Possenti, Sean Chia, Pietro Sormanni, Bernardino Ghetti, Byron Caughey, Tuomas P J Knowles, Christopher M Dobson
Discovery of potent inhibitors of α-synuclein aggregation using structure-based iterative learning. Nature chemical biology 20 (5) (2024)
Robert I Horne, Ewa A Andrzejewska, Parvez Alam, Z Faidon Brotzakis, Ankit Srivastava, Alice Aubert, Magdalena Nowinska, Rebecca C Gregory, Roxine Staats, Andrea Possenti, Sean Chia, Pietro Sormanni, Bernardino Ghetti, Byron Caughey, Tuomas P J Knowles, Christopher M Dobson
Discovery of potent inhibitors of α-synuclein aggregation using structure-based iterative learning. Nature chemical biology (2024)
Robert I Horne, Jared Wilson-Godber, Alicia González Díaz, Z Faidon Brotzakis, Srijit Seal, Rebecca C Gregory, Andrea Possenti, Sean Chia, Christopher M Dobson
Using Generative Modeling to Endow with Potency Initially Inert Compounds with Good Bioavailability and Low Toxicity. Journal of chemical information and modeling 64 (3) (2024)
Robert I Horne, Jared Wilson-Godber, Alicia González Díaz, Z Faidon Brotzakis, Srijit Seal, Rebecca C Gregory, Andrea Possenti, Sean Chia, Christopher M Dobson
Using Generative Modeling to Endow with Potency Initially Inert Compounds with Good Bioavailability and Low Toxicity. Journal of chemical information and modeling 64 (3) (2024)
Raghav Chandra, Robert I Horne, Christopher M Dobson
Bayesian Optimization in the Latent Space of a Variational Autoencoder for the Generation of Selective FLT3 Inhibitors. Journal of chemical theory and computation 20 (1) (2023)
Raghav Chandra, Robert I Horne, Christopher M Dobson
Bayesian Optimization in the Latent Space of a Variational Autoencoder for the Generation of Selective FLT3 Inhibitors. Journal of chemical theory and computation 20 (1) (2023)
Raghav Chandra, Robert I Horne, Christopher M Dobson
Bayesian Optimization in the Latent Space of a Variational Autoencoder for the Generation of Selective FLT3 Inhibitors. Journal of chemical theory and computation 20 (1) (2023)
Robert I Horne, Michael A Metrick, Wing Man, Dillon J Rinauro, Z Faidon Brotzakis, Sean Chia, Georg Meisl, Christopher M Dobson
Secondary Processes Dominate the Quiescent, Spontaneous Aggregation of α-Synuclein at Physiological pH with Sodium Salts. ACS chemical neuroscience (2023)
Sarah E Sandler, Robert I Horne, Sara Rocchetti, Robert Novak, Nai-Shu Hsu, Marta Castellana Cruz, Z Faidon Brotzakis, Rebecca C Gregory, Sean Chia, Gonçalo J L Bernardes, Ulrich F Keyser, Christopher M Dobson
Multiplexed Digital Characterization of Misfolded Protein Oligomers via Solid-State Nanopores. Journal of the American Chemical Society (2023)
Raghav Chandra, Robert I Horne, Christopher M Dobson
Bayesian Optimization in the Latent Space of a Variational Autoencoder for the Generation of Selective FLT3 Inhibitors. Journal of chemical theory and computation (2023)
Robert I Horne, Mhd Hussein Murtada, Donghui Huo, Z Faidon Brotzakis, Rebecca C Gregory, Andrea Possenti, Sean Chia, Christopher M Dobson
Exploration and Exploitation Approaches Based on Generative Machine Learning to Identify Potent Small Molecule Inhibitors of α-Synuclein Secondary Nucleation. Journal of chemical theory and computation (2023)
Raghav Chandra, Robert I Horne, Christopher M Dobson
Bayesian Optimization in the Latent Space of a Variational Autoencoder for the Generation of Selective FLT3 Inhibitors. Journal of chemical theory and computation 20 (1) (2023)
Francesco Simone Ruggeri, Johnny Habchi, Sean Chia, Robert I Horne, Christopher M Dobson, Tuomas P J Knowles
Infrared nanospectroscopy reveals the molecular interaction fingerprint of an aggregation inhibitor with single Aβ42 oligomers. Nature communications 12 (1) (2021)
Roxine Staats, Thomas C T Michaels, Patrick Flagmeier, Sean Chia, Robert I Horne, Johnny Habchi, Sara Linse, Tuomas P J Knowles, Christopher M Dobson, Christopher M Dobson
Screening of small molecules using the inhibition of oligomer formation in α-synuclein aggregation as a selection parameter. Communications chemistry 3 (1) (2020)
Roxine Staats, Thomas C T Michaels, Patrick Flagmeier, Sean Chia, Robert I Horne, Johnny Habchi, Sara Linse, Tuomas P J Knowles, Christopher M Dobson, Christopher M Dobson
Screening of small molecules using the inhibition of oligomer formation in α-synuclein aggregation as a selection parameter. Communications chemistry 3 (1) (2020)