Gonçalo J L Bernardes (G J L Bernardes)

Scopus Author ID ORCID

Publication Activity (10 Years)

Years Active: 2016-2024
Publications (10 Years): 110

Top Venues

Journal of the American Chemical Society

Angewandte Chemie (International ed. in English)

Bioconjugate chemistry

ACS chemical biology

Instituto de Medicina Molecular

This page only lists publications with an associated author ORCID identifier.

Affiliation History

Instituto de Medicina Molecular

Portugal

Group Leader

University of Cambridge Medicine

United Kingdom

Group Leader :: Chemistry

Publications

Aldrin V Vasco, Ross J Taylor, Yanira Méndez, Gonçalo J L Bernardes
On-Demand Thio-Succinimide Hydrolysis for the Assembly of Stable Protein-Protein Conjugates. Journal of the American Chemical Society 146 (30) (2024)
Barbara Bernardim, João Conde, Tuuli A Hakala, Julie B Becher, Mary Canzano, Aldrin V Vasco, Tuomas P J Knowles, Jason Cameron, Gonçalo J L Bernardes
Cathepsin B Processing Is Required for the In Vivo Efficacy of Albumin-Drug Conjugates. Bioconjugate chemistry 35 (2) (2024)
Luís A R Carvalho, Bárbara B Sousa, Daniel Zaidman, Hannah Kiely-Collins, Gonçalo J L Bernardes
Design and Evaluation of PROTACs Targeting Acyl Protein Thioesterase 1. Chembiochem : a European journal of chemical biology 25 (4) (2024)
Aldrin V Vasco, Ross J Taylor, Yanira Méndez, Gonçalo J L Bernardes
On-Demand Thio-Succinimide Hydrolysis for the Assembly of Stable Protein-Protein Conjugates. Journal of the American Chemical Society 146 (30) (2024)
Barbara Bernardim, João Conde, Tuuli A Hakala, Julie B Becher, Mary Canzano, Aldrin V Vasco, Tuomas P J Knowles, Jason Cameron, Gonçalo J L Bernardes
Cathepsin B Processing Is Required for the In Vivo Efficacy of Albumin-Drug Conjugates. Bioconjugate chemistry 35 (2) (2024)
V B Unnikrishnan, Valerio Sabatino, Filipa Amorim, Marta F Estrada, Claudio D Navo, Gonzalo Jiménez-Osés, Rita Fior, Gonçalo J L Bernardes
Gold(III)-Induced Amide Bond Cleavage In Vivo: A Dual Release Strategy via π-Acid Mediated Allyl Substitution. Journal of the American Chemical Society 146 (33) (2024)
Toby Journeaux, Gonçalo J L Bernardes
Homogeneous multi-payload antibody-drug conjugates. Nature chemistry 16 (6) (2024)
Toby Journeaux, Gonçalo J L Bernardes
Homogeneous multi-payload antibody-drug conjugates. Nature chemistry (2024)
V B Unnikrishnan, Valerio Sabatino, Filipa Amorim, Marta F Estrada, Claudio D Navo, Gonzalo Jiménez-Osés, Rita Fior, Gonçalo J L Bernardes
Gold(III)-Induced Amide Bond Cleavage In Vivo: A Dual Release Strategy via π-Acid Mediated Allyl Substitution. Journal of the American Chemical Society 146 (33) (2024)
Luís A R Carvalho, Bárbara B Sousa, Daniel Zaidman, Hannah Kiely-Collins, Gonçalo J L Bernardes
Design and Evaluation of PROTACs Targeting Acyl Protein Thioesterase 1. Chembiochem : a European journal of chemical biology (2024)
Luís A R Carvalho, Bárbara B Sousa, Daniel Zaidman, Hannah Kiely-Collins, Gonçalo J L Bernardes
Design and Evaluation of PROTACs Targeting Acyl Protein Thioesterase 1. Chembiochem : a European journal of chemical biology 25 (4) (2024)
Barbara Bernardim, João Conde, Tuuli A Hakala, Julie B Becher, Mary Canzano, Aldrin V Vasco, Tuomas P J Knowles, Jason Cameron, Gonçalo J L Bernardes
Cathepsin B Processing Is Required for the In Vivo Efficacy of Albumin-Drug Conjugates. Bioconjugate chemistry 35 (2) (2024)
Aldrin V Vasco, Ross J Taylor, Yanira Méndez, Gonçalo J L Bernardes
On-Demand Thio-Succinimide Hydrolysis for the Assembly of Stable Protein-Protein Conjugates. Journal of the American Chemical Society (2024)
Barbara Bernardim, João Conde, Tuuli A Hakala, Julie B Becher, Mary Canzano, Aldrin V Vasco, Tuomas P J Knowles, Jason Cameron, Gonçalo J L Bernardes
Cathepsin B Processing Is Required for the In Vivo Efficacy of Albumin-Drug Conjugates. Bioconjugate chemistry (2024)
V B Unnikrishnan, Valerio Sabatino, Filipa Amorim, Marta F Estrada, Claudio D Navo, Gonzalo Jiménez-Osés, Rita Fior, Gonçalo J L Bernardes
Gold(III)-Induced Amide Bond Cleavage In Vivo: A Dual Release Strategy via π-Acid Mediated Allyl Substitution. Journal of the American Chemical Society 146 (33) (2024)
Libby Brown, Aldrin V Vasco, Ana Laura Dias, Tiago Rodrigues, Anna Sigurdardottir, Toby Journeaux, Siobhan O'Brien, Thomas V Murray, Peter Ravn, Monika Papworth, Gonçalo J L Bernardes
Proximity-driven site-specific cyclization of phage-displayed peptides. Nature communications 15 (1) (2024)
Barbara Bernardim, João Conde, Tuuli A Hakala, Julie B Becher, Mary Canzano, Aldrin V Vasco, Tuomas P J Knowles, Jason Cameron, Gonçalo J L Bernardes
Cathepsin B Processing Is Required for the In Vivo Efficacy of Albumin-Drug Conjugates. Bioconjugate chemistry 35 (2) (2024)
Libby Brown, Aldrin V Vasco, Ana Laura Dias, Tiago Rodrigues, Anna Sigurdardottir, Toby Journeaux, Siobhan O'Brien, Thomas V Murray, Peter Ravn, Monika Papworth, Gonçalo J L Bernardes
Proximity-driven site-specific cyclization of phage-displayed peptides. Nature communications 15 (1) (2024)
Luís A R Carvalho, Bárbara B Sousa, Daniel Zaidman, Hannah Kiely-Collins, Gonçalo J L Bernardes
Design and Evaluation of PROTACs Targeting Acyl Protein Thioesterase 1. Chembiochem : a European journal of chemical biology 25 (4) (2024)
V B Unnikrishnan, Valerio Sabatino, Filipa Amorim, Marta F Estrada, Claudio D Navo, Gonzalo Jiménez-Osés, Rita Fior, Gonçalo J L Bernardes
Gold(III)-Induced Amide Bond Cleavage In Vivo: A Dual Release Strategy via π-Acid Mediated Allyl Substitution. Journal of the American Chemical Society (2024)
Aldrin V Vasco, Ross J Taylor, Yanira Méndez, Gonçalo J L Bernardes
On-Demand Thio-Succinimide Hydrolysis for the Assembly of Stable Protein-Protein Conjugates. Journal of the American Chemical Society 146 (30) (2024)
Toby Journeaux, Gonçalo J L Bernardes
Homogeneous multi-payload antibody-drug conjugates. Nature chemistry 16 (6) (2024)
Barbara Bernardim, João Conde, Tuuli A Hakala, Julie B Becher, Mary Canzano, Aldrin V Vasco, Tuomas P J Knowles, Jason Cameron, Gonçalo J L Bernardes
Cathepsin B Processing Is Required for the In Vivo Efficacy of Albumin-Drug Conjugates. Bioconjugate chemistry 35 (2) (2024)
Barbara Bernardim, João Conde, Tuuli A Hakala, Julie B Becher, Mary Canzano, Aldrin V Vasco, Tuomas P J Knowles, Jason Cameron, Gonçalo J L Bernardes
Cathepsin B Processing Is Required for the In Vivo Efficacy of Albumin-Drug Conjugates. Bioconjugate chemistry 35 (2) (2024)
Gean M Dal Forno, Eloah Latocheski, Ana Beatriz Machado, Julie Becher, Lavinia Dunsmore, Albert L St John, Bruno L Oliveira, Claudio D Navo, Gonzalo Jiménez-Osés, Rita Fior, Josiel B Domingos, Gonçalo J L Bernardes
Expanding Transition Metal-Mediated Bioorthogonal Decaging to Include C-C Bond Cleavage Reactions. Journal of the American Chemical Society 145 (19) (2023)
Karthik Nadendla, Grant G Simpson, Julie Becher, Toby Journeaux, Mar Cabeza-Cabrerizo, Gonçalo J L Bernardes
Strategies for Conditional Regulation of Proteins. JACS Au 3 (2) (2023)
Gean M Dal Forno, Eloah Latocheski, Ana Beatriz Machado, Julie Becher, Lavinia Dunsmore, Albert L St John, Bruno L Oliveira, Claudio D Navo, Gonzalo Jiménez-Osés, Rita Fior, Josiel B Domingos, Gonçalo J L Bernardes
Expanding Transition Metal-Mediated Bioorthogonal Decaging to Include C-C Bond Cleavage Reactions. Journal of the American Chemical Society 145 (19) (2023)
Sigitas Mikutis, Stefanie Lawrinowitz, Christian Kretzer, Lavinia Dunsmore, Laurynas Sketeris, Tiago Rodrigues, Oliver Werz, Gonçalo J L Bernardes
Machine Learning Uncovers Natural Product Modulators of the 5-Lipoxygenase Pathway and Facilitates the Elucidation of Their Biological Mechanisms. ACS chemical biology (2023)
Sigitas Mikutis, Stefanie Lawrinowitz, Christian Kretzer, Lavinia Dunsmore, Laurynas Sketeris, Tiago Rodrigues, Oliver Werz, Gonçalo J L Bernardes
Machine Learning Uncovers Natural Product Modulators of the 5-Lipoxygenase Pathway and Facilitates the Elucidation of Their Biological Mechanisms. ACS chemical biology 19 (1) (2023)
Sigitas Mikutis, Stefanie Lawrinowitz, Christian Kretzer, Lavinia Dunsmore, Laurynas Sketeris, Tiago Rodrigues, Oliver Werz, Gonçalo J L Bernardes
Machine Learning Uncovers Natural Product Modulators of the 5-Lipoxygenase Pathway and Facilitates the Elucidation of Their Biological Mechanisms. ACS chemical biology 19 (1) (2023)
Sigitas Mikutis, Stefanie Lawrinowitz, Christian Kretzer, Lavinia Dunsmore, Laurynas Sketeris, Tiago Rodrigues, Oliver Werz, Gonçalo J L Bernardes
Machine Learning Uncovers Natural Product Modulators of the 5-Lipoxygenase Pathway and Facilitates the Elucidation of Their Biological Mechanisms. ACS chemical biology 19 (1) (2023)
Sarah E Sandler, Robert I Horne, Sara Rocchetti, Robert Novak, Nai-Shu Hsu, Marta Castellana Cruz, Z Faidon Brotzakis, Rebecca C Gregory, Sean Chia, Gonçalo J L Bernardes, Ulrich F Keyser, Christopher M Dobson
Multiplexed Digital Characterization of Misfolded Protein Oligomers via Solid-State Nanopores. Journal of the American Chemical Society (2023)
Iris A Bermejo, Ana Guerreiro, Ander Eguskiza, Nuria Martínez-Sáez, Foivos S Lazaris, Alicia Asín, Víctor J Somovilla, Ismael Compañón, Tom K Raju, Srdan Tadic, Pablo Garrido, Josune García-Sanmartín, Vincenzo Mangini, Ana S Grosso, Filipa Marcelo, Alberto Avenoza, Jesús H Busto, Fayna García-Martín, Ramon Hurtado Guerrero, Jesus M Peregrina, Gonçalo J L Bernardes, Alfredo Martínez, Roberto Fiammengo, Francisco Corzana
Structure-Guided Approach for the Development of MUC1-Glycopeptide-Based Cancer Vaccines with Predictable Responses. JACS Au 4 (1) (2023)
Gean M Dal Forno, Eloah Latocheski, Ana Beatriz Machado, Julie Becher, Lavinia Dunsmore, Albert L St John, Bruno L Oliveira, Claudio D Navo, Gonzalo Jiménez-Osés, Rita Fior, Josiel B Domingos, Gonçalo J L Bernardes
Expanding Transition Metal-Mediated Bioorthogonal Decaging to Include C-C Bond Cleavage Reactions. Journal of the American Chemical Society (2023)
Sigitas Mikutis, Maria Rebelo, Eliza Yankova, Muxin Gu, Cong Tang, Ana R Coelho, Mo Yang, Madoka E Hazemi, Marta Pires de Miranda, Maria Eleftheriou, Max Robertson, George S Vassiliou, David J Adams, J Pedro Simas, Francisco Corzana, John S Schneekloth, Konstantinos Tzelepis, Gonçalo J L Bernardes
Proximity-Induced Nucleic Acid Degrader (PINAD) Approach to Targeted RNA Degradation Using Small Molecules. ACS central science 9 (5) (2023)
Iris A Bermejo, Ana Guerreiro, Ander Eguskiza, Nuria Martínez-Sáez, Foivos S Lazaris, Alicia Asín, Víctor J Somovilla, Ismael Compañón, Tom K Raju, Srdan Tadic, Pablo Garrido, Josune García-Sanmartín, Vincenzo Mangini, Ana S Grosso, Filipa Marcelo, Alberto Avenoza, Jesús H Busto, Fayna García-Martín, Ramon Hurtado Guerrero, Jesus M Peregrina, Gonçalo J L Bernardes, Alfredo Martínez, Roberto Fiammengo, Francisco Corzana
Structure-Guided Approach for the Development of MUC1-Glycopeptide-Based Cancer Vaccines with Predictable Responses. JACS Au 4 (1) (2023)
Gean M Dal Forno, Eloah Latocheski, Ana Beatriz Machado, Julie Becher, Lavinia Dunsmore, Albert L St John, Bruno L Oliveira, Claudio D Navo, Gonzalo Jiménez-Osés, Rita Fior, Josiel B Domingos, Gonçalo J L Bernardes
Expanding Transition Metal-Mediated Bioorthogonal Decaging to Include C-C Bond Cleavage Reactions. Journal of the American Chemical Society 145 (19) (2023)
Gean M Dal Forno, Eloah Latocheski, Ana Beatriz Machado, Julie Becher, Lavinia Dunsmore, Albert L St John, Bruno L Oliveira, Claudio D Navo, Gonzalo Jiménez-Osés, Rita Fior, Josiel B Domingos, Gonçalo J L Bernardes
Expanding Transition Metal-Mediated Bioorthogonal Decaging to Include C-C Bond Cleavage Reactions. Journal of the American Chemical Society 145 (19) (2023)
Gean M Dal Forno, Eloah Latocheski, Ana Beatriz Machado, Julie Becher, Lavinia Dunsmore, Albert L St John, Bruno L Oliveira, Claudio D Navo, Gonzalo Jiménez-Osés, Rita Fior, Josiel B Domingos, Gonçalo J L Bernardes
Expanding Transition Metal-Mediated Bioorthogonal Decaging to Include C-C Bond Cleavage Reactions. Journal of the American Chemical Society 145 (19) (2023)
Sigitas Mikutis, Stefanie Lawrinowitz, Christian Kretzer, Lavinia Dunsmore, Laurynas Sketeris, Tiago Rodrigues, Oliver Werz, Gonçalo J L Bernardes
Machine Learning Uncovers Natural Product Modulators of the 5-Lipoxygenase Pathway and Facilitates the Elucidation of Their Biological Mechanisms. ACS chemical biology 19 (1) (2023)
Sigitas Mikutis, Stefanie Lawrinowitz, Christian Kretzer, Lavinia Dunsmore, Laurynas Sketeris, Tiago Rodrigues, Oliver Werz, Gonçalo J L Bernardes
Machine Learning Uncovers Natural Product Modulators of the 5-Lipoxygenase Pathway and Facilitates the Elucidation of Their Biological Mechanisms. ACS chemical biology 19 (1) (2023)
Karthik Nadendla, Grant G Simpson, Julie Becher, Toby Journeaux, Mar Cabeza-Cabrerizo, Gonçalo J L Bernardes
Strategies for Conditional Regulation of Proteins. JACS Au 3 (2) (2023)
Cong Tang, Ana R Coelho, Maria Rebelo, Hannah Kiely-Collins, Tânia Carvalho, Gonçalo J L Bernardes
A Selective SARS-CoV-2 Host-Directed Antiviral Targeting Stress Response to Reactive Oxygen Species. ACS central science 9 (1) (2023)
Gonçalo J L Bernardes, Peng Zou, Zhifei Dai, Erin B Lavik, Jan C M Van Hest, Gang Zheng, Nathan Quinn, Christina M MacLaughlin, Theresa M Reineke
Introducing the 2023 Bioconjugate Chemistry Editorial Team. Bioconjugate chemistry 34 (2) (2023)
Gean M Dal Forno, Eloah Latocheski, Ana Beatriz Machado, Julie Becher, Lavinia Dunsmore, Albert L St John, Bruno L Oliveira, Claudio D Navo, Gonzalo Jiménez-Osés, Rita Fior, Josiel B Domingos, Gonçalo J L Bernardes
Expanding Transition Metal-Mediated Bioorthogonal Decaging to Include C-C Bond Cleavage Reactions. Journal of the American Chemical Society (2023)
Cong Tang, Ana R Coelho, Maria Rebelo, Hannah Kiely-Collins, Tânia Carvalho, Gonçalo J L Bernardes
A Selective SARS-CoV-2 Host-Directed Antiviral Targeting Stress Response to Reactive Oxygen Species. ACS central science 9 (1) (2023)
Maria Rebelo, Cong Tang, Ana R Coelho, Carlos Labão-Almeida, Matthias M Schneider, Laurie Tatalick, Pedro Ruivo, Marta Pires de Miranda, Andreia Gomes, Tânia Carvalho, Matthew J Walker, Hannes Ausserwoeger, J Pedro Simas, Marc Veldhoen, Tuomas P J Knowles, Daniel-Adriano Silva, David Shoultz, Gonçalo J L Bernardes
De Novo Human Angiotensin-Converting Enzyme 2 Decoy NL-CVX1 Protects Mice From Severe Disease After Severe Acute Respiratory Syndrome Coronavirus 2 Infection. The Journal of infectious diseases (2023)
Alena Istrate, Michael B Geeson, Claudio D Navo, Barbara B Sousa, Marta C Marques, Ross J Taylor, Toby Journeaux, Sebastian R Oehler, Michael R Mortensen, Michael J Deery, Andrew D Bond, Francisco Corzana, Gonzalo Jiménez-Osés, Gonçalo J L Bernardes
Platform for Orthogonal N -Cysteine-Specific Protein Modification Enabled by Cyclopropenone Reagents. Journal of the American Chemical Society 144 (23) (2022)
Ruth A Pumroy, Anna D Protopopova, Tabea C Fricke, Iris U Lange, Ferdinand M Haug, Phuong T Nguyen, Pamela N Gallo, Bárbara B Sousa, Gonçalo J L Bernardes, Vladimir Yarov-Yarovoy, Andreas Leffler, Vera Y Moiseenkova-Bell
Structural insights into TRPV2 activation by small molecules. Nature communications 13 (1) (2022)
Cláudia F Afonso, Marta C Marques, João P M António, Carlos Cordeiro, Pedro M P Gois, Pedro M S D Cal, Gonçalo J L Bernardes
Cysteine-Assisted Click-Chemistry for Proximity-Driven, Site-Specific Acetylation of Histones. Angewandte Chemie (International ed. in English) 61 (46) (2022)
Bárbara B Sousa, Cátia Rebelo de Almeida, Ana F Barahona, Raquel Lopes, Ana Martins-Logrado, Marco Cavaco, Vera Neves, Luís A R Carvalho, Carlos Labão-Almeida, Ana R Coelho, Marta Leal Bento, Ricardo M R M Lopes, Bruno L Oliveira, Miguel A R B Castanho, Peter Neumeister, Alexander Deutsch, Gregory I Vladimer, Nikolaus Krall, Cristina João, Francisco Corzana, João D Seixas, Rita Fior, Gonçalo J L Bernardes
Selective Inhibition of Bruton's Tyrosine Kinase by a Designed Covalent Ligand Leads to Potent Therapeutic Efficacy in Blood Cancers Relative to Clinically Used Inhibitors. ACS pharmacology & translational science 5 (11) (2022)
Mauricio Aguilar Rangel, Alice Bedwell, Elisa Costanzi, Ross J Taylor, Rosaria Russo, Gonçalo J L Bernardes, Stefano Ricagno, Judith Frydman, Christopher M Dobson, Pietro Sormanni
Fragment-based computational design of antibodies targeting structured epitopes. Science advances 8 (45) (2022)
Filippo Carboni, Annabel Kitowski, Charlotte Sorieul, Daniele Veggi, Marta C Marques, Davide Oldrini, Evita Balducci, Barbara Brogioni, Linda Del Bino, Alessio Corrado, Francesca Angiolini, Lucia Dello Iacono, Immaculada Margarit, Maria Rosaria Romano, Gonçalo J L Bernardes, Roberto Adamo
Retaining the structural integrity of disulfide bonds in diphtheria toxoid carrier protein is crucial for the effectiveness of glycoconjugate vaccine candidates. Chemical science 13 (8) (2022)
Lavinia Dunsmore, Claudio D Navo, Julie Becher, Enrique Gil de Montes, Ana Guerreiro, Emily A Hoyt, Libby Brown, Viviane Zelenay, Sigitas Mikutis, Jonathan Cooper, Isaia Barbieri, Stefanie Lawrinowitz, Elise Siouve, Esther Martin, Pedro R Ruivo, Tiago Rodrigues, Filipa P da Cruz, Oliver Werz, George S Vassiliou, Peter Ravn, Gonzalo Jiménez-Osés, Gonçalo J L Bernardes
Controlled masking and targeted release of redox-cycling ortho-quinones via a C-C bond-cleaving 1,6-elimination. Nature chemistry 14 (7) (2022)
Luís A R Carvalho, Gonçalo J L Bernardes
The Impact of Activity-Based Protein Profiling in Malaria Drug Discovery. ChemMedChem 17 (14) (2022)
Ross J Taylor, Mauricio Aguilar Rangel, Michael B Geeson, Pietro Sormanni, Christopher M Dobson, Gonçalo J L Bernardes
π-Clamp-Mediated Homo- and Heterodimerization of Single-Domain Antibodies via Site-Specific Homobifunctional Conjugation. Journal of the American Chemical Society 144 (29) (2022)
Xhenti Ferhati, Ester Jiménez-Moreno, Emily A Hoyt, Giulia Salluce, Mar Cabeza-Cabrerizo, Claudio D Navo, Ismael Compañón, Padma Akkapeddi, Maria João Matos, Noelia Salaverri, Pablo Garrido, Alfredo Martínez, Víctor Laserna, Thomas V Murray, Gonzalo Jiménez-Osés, Peter Ravn, Gonçalo J L Bernardes, Francisco Corzana
Single Mutation on Trastuzumab Modulates the Stability of Antibody-Drug Conjugates Built Using Acetal-Based Linkers and Thiol-Maleimide Chemistry. Journal of the American Chemical Society 144 (12) (2022)
Xhenti Ferhati, Marina Salas-Cubero, Pablo Garrido, Josune García-Sanmartín, Ana Guerreiro, Alberto Avenoza, Jesús H Busto, Jesus M Peregrina, Alfredo Martínez, Ester Jiménez-Moreno, Gonçalo J L Bernardes, Francisco Corzana
Bioorthogonal Self-Immolative Linker Based on Grob Fragmentation. Organic letters 23 (21) (2021)
João Conde, Ruth A Pumroy, Charlotte Baker, Tiago Rodrigues, Ana Guerreiro, Bárbara B Sousa, Marta C Marques, Bernardo P de Almeida, Sohyon Lee, Elvira P Leites, Daniel Picard, Amrita Samanta, Sandra H Vaz, Florian Sieglitz, Maike Langini, Marc Remke, Rafael Roque, Tobias Weiss, Michael Weller, Yuhang Liu, Seungil Han, Francisco Corzana, Vanessa A Morais, Cláudia C Faria, Tânia Carvalho, Panagis Filippakopoulos, Berend Snijder, Nuno L Barbosa-Morais, Vera Y Moiseenkova-Bell, Gonçalo J L Bernardes
Allosteric Antagonist Modulation of TRPV2 by Piperlongumine Impairs Glioblastoma Progression. ACS central science 7 (5) (2021)
Tuuli A Hakala, Emma V Yates, Pavan Kumar Challa, Zenon Toprakcioglu, Karthik Nadendla, Dijana Matak-Vinkovic, Christopher M Dobson, Rodrigo Martínez, Francisco Corzana, Tuomas P J Knowles, Gonçalo J L Bernardes
Accelerating Reaction Rates of Biomolecules by Using Shear Stress in Artificial Capillary Systems. Journal of the American Chemical Society 143 (40) (2021)
Z Faidon Brotzakis, Philip R Lindstedt, Ross J Taylor, Dillon J Rinauro, Nicholas C T Gallagher, Gonçalo J L Bernardes, Christopher M Dobson
A Structural Ensemble of a Tau-Microtubule Complex Reveals Regulatory Tau Phosphorylation and Acetylation Mechanisms. ACS central science 7 (12) (2021)
Juraj Konč, Libby Brown, Daniel R Whiten, Yukun Zuo, Peter Ravn, David Klenerman, Gonçalo J L Bernardes
A Platform for Site-Specific DNA-Antibody Bioconjugation by Using Benzoylacrylic-Labelled Oligonucleotides. Angewandte Chemie (International ed. in English) 60 (49) (2021)
Victor Laserna, Alena Istrate, Kevin Kafuta, Tuuli A Hakala, Tuomas P J Knowles, Manuel Alcarazo, Gonçalo J L Bernardes
Protein Conjugation by Electrophilic Alkynylation Using 5-(Alkynyl)dibenzothiophenium Triflates. Bioconjugate chemistry 32 (8) (2021)
Victor Laserna, Daniel Abegg, Cláudia F Afonso, Esther M Martin, Alexander Adibekian, Peter Ravn, Francisco Corzana, Gonçalo J L Bernardes
Dichloro Butenediamides as Irreversible Site-Selective Protein Conjugation Reagent. Angewandte Chemie (International ed. in English) 60 (44) (2021)
Philip R Lindstedt, Ross J Taylor, Gonçalo J L Bernardes, Christopher M Dobson
Facile Installation of Post-translational Modifications on the Tau Protein via Chemical Mutagenesis. ACS chemical neuroscience 12 (3) (2021)
Zbigniew Zawada, Zijian Guo, Bruno L Oliveira, Claudio D Navo, He Li, Pedro M S D Cal, Francisco Corzana, Gonzalo Jiménez-Osés, Gonçalo J L Bernardes
Arylethynyltrifluoroborate Dienophiles for on Demand Activation of IEDDA Reactions. Bioconjugate chemistry 32 (8) (2021)
Konstantin Neukirch, Khaled Alsabil, Chau-Phi Dinh, Rossella Bilancia, Martin Raasch, Alexia Ville, Ida Cerqua, Guillaume Viault, Dimitri Bréard, Simona Pace, Veronika Temml, Elena Brunner, Paul M Jordan, Marta C Marques, Konstantin Loeser, André Gollowitzer, Stephan Permann, Jana Gerstmeier, Stefan Lorkowski, Hermann Stuppner, Ulrike Garscha, Tiago Rodrigues, Gonçalo J L Bernardes, Daniela Schuster, Denis Séraphin, Pascal Richomme, Antonietta Rossi, Alexander S Mosig, Fiorentina Roviezzo, Oliver Werz, Jean-Jacques Helesbeux, Andreas Koeberle
Exploration of Long-Chain Vitamin E Metabolites for the Discovery of a Highly Potent, Orally Effective, and Metabolically Stable 5-LOX Inhibitor that Limits Inflammation. Journal of medicinal chemistry 64 (15) (2021)
Tuuli A Hakala, Friedrich Bialas, Zenon Toprakcioglu, Birgit Bräuer, Kevin N Baumann, Aviad Levin, Gonçalo J L Bernardes, Christian Friedrich Wilhelm Becker, Tuomas P J Knowles
Continuous Flow Reactors from Microfluidic Compartmentalization of Enzymes within Inorganic Microparticles. ACS applied materials & interfaces 12 (29) (2020)
Bruno L Oliveira, Benjamin J Stenton, V B Unnikrishnan, Cátia Rebelo de Almeida, João Conde, Magda Negrão, Felipe S S Schneider, Carlos Cordeiro, Miguel Godinho Ferreira, Giovanni Finoto Caramori, Josiel B Domingos, Rita Fior, Gonçalo J L Bernardes
Platinum-Triggered Bond-Cleavage of Pentynoyl Amide and N-Propargyl Handles for Drug-Activation. Journal of the American Chemical Society 142 (24) (2020)
Enrique Gil de Montes, Alena Istrate, Claudio D Navo, Ester Jiménez-Moreno, Emily A Hoyt, Francisco Corzana, Inmaculada Robina, Gonzalo Jiménez-Osés, Antonio J Moreno-Vargas, Gonçalo J L Bernardes
Stable Pyrrole-Linked Bioconjugates through Tetrazine-Triggered Azanorbornadiene Fragmentation. Angewandte Chemie (International ed. in English) 59 (15) (2020)
Kirsten McAulay, Emily A Hoyt, Morgan Thomas, Marianne Schimpl, Michael S Bodnarchuk, Hilary J Lewis, Derek Barratt, Deepa Bhavsar, David M Robinson, Michael J Deery, Derek J Ogg, Gonçalo J L Bernardes, Richard A Ward, Michael J Waring, Jason G Kettle
Alkynyl Benzoxazines and Dihydroquinazolines as Cysteine Targeting Covalent Warheads and Their Application in Identification of Selective Irreversible Kinase Inhibitors. Journal of the American Chemical Society 142 (23) (2020)
Iris A Bermejo, Claudio D Navo, Jorge Castro-López, Ana Guerreiro, Ester Jiménez-Moreno, Elena M Sánchez Fernández, Fayna García-Martín, Hiroshi Hinou, Shin-Ichiro Nishimura, José Manuel García Fernández, Carmen Ortiz Mellet, Alberto Avenoza, Jesús H Busto, Gonçalo J L Bernardes, Ramón Hurtado-Guerrero, Jesus M Peregrina, Francisco Corzana
Synthesis, conformational analysis and in vivo assays of an anti-cancer vaccine that features an unnatural antigen based on an sp2-iminosugar fragment. Chemical science 11 (15) (2020)
Julien C Vantourout, Srinivasa Rao Adusumalli, Kyle W Knouse, Dillon T Flood, Antonio Ramirez, Natalia M Padial, Alena Istrate, Katarzyna Maziarz, Justine N deGruyter, Rohan R Merchant, Jennifer X Qiao, Michael A Schmidt, Michael J Deery, Martin D Eastgate, Phillip E Dawson, Gonçalo J L Bernardes, Phil S Baran
Serine-Selective Bioconjugation. Journal of the American Chemical Society 142 (41) (2020)
João D Seixas, Bárbara B Sousa, Marta C Marques, Ana Guerreiro, Rui Traquete, Tiago Rodrigues, Inês S Albuquerque, Marcos F Q Sousa, Ana R Lemos, Pedro M F Sousa, Tiago M Bandeiras, Di Wu, Shelby K Doyle, Michael Landreh, Angela N Koehler, Francisco Corzana, Pedro M Matias, Gonçalo J L Bernardes
Structural and biophysical insights into the mode of covalent binding of rationally designed potent BMX inhibitors. RSC chemical biology 1 (4) (2020)
Vera F C Ferreira, Bruno L Oliveira, Alice D'Onofrio, Carlos M Farinha, Lurdes Gano, António Paulo, Gonçalo J L Bernardes, Filipa Mendes
In Vivo Pretargeting Based on Cysteine-Selective Antibody Modification with IEDDA Bioorthogonal Handles for Click Chemistry. Bioconjugate chemistry 32 (1) (2020)
He Li, João Conde, Ana Guerreiro, Gonçalo J L Bernardes
Tetrazine Carbon Nanotubes for Pretargeted In Vivo "Click-to-Release" Bioorthogonal Tumour Imaging. Angewandte Chemie (International ed. in English) 59 (37) (2020)
Annabel Kitowski, Gonçalo J L Bernardes
A Sweet Galactose Transfer: Metabolic Oligosaccharide Engineering as a Tool To Study Glycans in Plasmodium Infection. Chembiochem : a European journal of chemical biology 21 (18) (2020)
Barbara Bernardim, Lavinia Dunsmore, He Li, Brad Hocking, Reyes Nuñez-Franco, Claudio D Navo, Gonzalo Jiménez-Osés, Antonio Carlos Bender Burtoloso, Gonçalo J L Bernardes
Precise Installation of Diazo-Tagged Side-Chains on Proteins to Enable In Vitro and In-Cell Site-Specific Labeling. Bioconjugate chemistry 31 (6) (2020)
Tuuli A Hakala, Sarah Davies, Zenon Toprakcioglu, Barbara Bernardim, Gonçalo J L Bernardes, Tuomas P J Knowles
A Microfluidic Co-Flow Route for Human Serum Albumin-Drug-Nanoparticle Assembly. Chemistry (Weinheim an der Bergstrasse, Germany) 26 (27) (2020)
Lisa J Alcock, Bruno L Oliveira, Michael J Deery, Tara Louise Pukala, Michael V Perkins, Gonçalo J L Bernardes, Justin M Chalker
Norbornene Probes for the Detection of Cysteine Sulfenic Acid in Cells. ACS chemical biology 14 (4) (2019)
Maria J Matos, Claudio D Navo, Tuuli Hakala, Xhenti Ferhati, Ana Guerreiro, David Hartmann, Barbara Bernardim, Kadi L Saar, Ismael Compañón, Francisco Corzana, Tuomas P J Knowles, Gonzalo Jiménez-Osés, Gonçalo J L Bernardes
Quaternization of Vinyl/Alkynyl Pyridine Enables Ultrafast Cysteine-Selective Protein Modification and Charge Modulation. Angewandte Chemie (International ed. in English) 58 (20) (2019)
Marta C Marques, Inês S Albuquerque, Sandra H Vaz, Gonçalo J L Bernardes
Overexpression of Osmosensitive Ca2+-Permeable Channel TMEM63B Promotes Migration in HEK293T Cells. Biochemistry 58 (26) (2019)
Ismael Compañón, Ana Guerreiro, Vincenzo Mangini, Jorge Castro-López, Margarita Escudero-Casao, Alberto Avenoza, Jesús H Busto, Sergio Castillón, Jiménez-Barbero Jesús, Juan L Asensio, Gonzalo Jiménez-Osés, Omar Boutureira, Jesus M Peregrina, Ramon Hurtado Guerrero, Roberto Fiammengo, Gonçalo J L Bernardes, Francisco Corzana
Structure-Based Design of Potent Tumor-Associated Antigens: Modulation of Peptide Presentation by Single-Atom O/S or O/Se Substitutions at the Glycosidic Linkage. Journal of the American Chemical Society 141 (9) (2019)
Daniel Reker, Gonçalo J L Bernardes, Tiago Rodrigues
Computational advances in combating colloidal aggregation in drug discovery. Nature chemistry 11 (5) (2019)
Sarah Davies, Luxi Qiao, Bruno L Oliveira, Claudio D Navo, Gonzalo Jiménez-Osés, Gonçalo J L Bernardes
Tetrazine-Triggered Release of Carboxylic-Acid-Containing Molecules for Activation of an Anti-inflammatory Drug. Chembiochem : a European journal of chemical biology 20 (12) (2019)
Barbara Bernardim, Maria João Matos, Xhenti Ferhati, Ismael Compañón, Ana Guerreiro, Padma Akkapeddi, Antonio C B Burtoloso, Gonzalo Jiménez-Osés, Francisco Corzana, Gonçalo J L Bernardes
Efficient and irreversible antibody-cysteine bioconjugation using carbonylacrylic reagents. Nature protocols 14 (1) (2019)
Enrique Gil de Montes, Ester Jiménez-Moreno, Bruno L Oliveira, Claudio D Navo, Pedro M S D Cal, Gonzalo Jiménez-Osés, Inmaculada Robina, Antonio J Moreno-Vargas, Gonçalo J L Bernardes
Azabicyclic vinyl sulfones for residue-specific dual protein labelling. Chemical science 10 (16) (2019)
Jean B Bertoldo, Hernán Terenzi, Stefan Hüttelmaier, Gonçalo J L Bernardes
Posttranslational Chemical Mutagenesis: To Reveal the Role of Noncatalytic Cysteine Residues in Pathogenic Bacterial Phosphatases. Biochemistry 57 (43) (2018)
Benjamin J Stenton, Bruno L Oliveira, Maria João Matos, Laura Sinatra, Gonçalo J L Bernardes
A thioether-directed palladium-cleavable linker for targeted bioorthogonal drug decaging. Chemical science 9 (17) (2018)
Tiago Rodrigues, Gonçalo J L Bernardes
Development of Antibody-Directed Therapies: Quo Vadis? Angewandte Chemie (International ed. in English) 57 (8) (2018)
Vincent E Zwicker, Bruno L Oliveira, Jia Hao Yeo, Stuart T Fraser, Gonçalo J L Bernardes, Elizabeth J New, Katrina A Jolliffe
A Fluorogenic Probe for Cell Surface Phosphatidylserine Using an Intramolecular Indicator Displacement Sensing Mechanism. Angewandte Chemie (International ed. in English) 58 (10) (2018)
Maria João Matos, Carlos Labão-Almeida, Claire Sayers, Oyinlola Dada, Matthias Tacke, Gonçalo J L Bernardes
Synthesis and Biological Evaluation of Homogeneous Thiol-Linked NHC*-Au-Albumin and -Trastuzumab Bioconjugates. Chemistry (Weinheim an der Bergstrasse, Germany) 24 (47) (2018)
Maria J Matos, Bruno L Oliveira, Nuria Martínez-Sáez, Ana Guerreiro, Pedro M S D Cal, Jean Bertoldo, María Maneiro, Elizabeth Perkins, Julie Howard, Michael J Deery, Justin M Chalker, Francisco Corzana, Gonzalo Jiménez-Osés, Gonçalo J L Bernardes
Chemo- and Regioselective Lysine Modification on Native Proteins. Journal of the American Chemical Society 140 (11) (2018)
Natalie L Mutter, Misha Soskine, Gang Huang, Inês S Albuquerque, Gonçalo J L Bernardes, Giovanni Maglia
Modular Pore-Forming Immunotoxins with Caged Cytotoxicity Tailored by Directed Evolution. ACS chemical biology 13 (11) (2018)
Tiago Rodrigues, Markus Werner, Jakob Roth, Eduardo H G da Cruz, Marta C Marques, Padma Akkapeddi, Susana A Lobo, Andreas Koeberle, Francisco Corzana, Eufrânio N da Silva Júnior, Oliver Werz, Gonçalo J L Bernardes
Machine intelligence decrypts β-lapachone as an allosteric 5-lipoxygenase inhibitor. Chemical science 9 (34) (2018)
B L Oliveira, Z Guo, Gonçalo J L Bernardes
Inverse electron demand Diels-Alder reactions in chemical biology. Chemical Society reviews 46 (16) (2018)
Shuang Sun, Bruno L Oliveira, Gonzalo Jiménez-Osés, Gonçalo J L Bernardes
Radical-Mediated Thiol-Ene Strategy: Photoactivation of Thiol-Containing Drugs in Cancer Cells. Angewandte Chemie (International ed. in English) 57 (48) (2018)
Woo Gyum Kim, Mi Eun Kang, Jae Bin Lee, Min Ho Jeon, Sungmin Lee, Jungha Lee, Bongseo Choi, Pedro M S D Cal, Sebyung Kang, Jung-Min Kee, Gonçalo J L Bernardes, Jan-Uwe Rohde, Wonyoung Choe, Sung You Hong
Nickel-Catalyzed Azide-Alkyne Cycloaddition To Access 1,5-Disubstituted 1,2,3-Triazoles in Air and Water. Journal of the American Chemical Society 139 (35) (2017)
Shuang Sun, Ismael Compañón, Nuria Martínez-Sáez, João D Seixas, Omar Boutureira, Francisco Corzana, Gonçalo J L Bernardes
Enhanced Permeability and Binding Activity of Isobutylene-Grafted Peptides. Chembiochem : a European journal of chemical biology 19 (1) (2017)
Víctor J Somovilla, Iris A Bermejo, Inês S Albuquerque, Nuria Martínez-Sáez, Jorge Castro-López, Fayna García-Martín, Ismael Compañón, Hiroshi Hinou, Shin-Ichiro Nishimura, Jiménez-Barbero Jesús, Juan L Asensio, Alberto Avenoza, Jesús H Busto, Ramón Hurtado-Guerrero, Jesus M Peregrina, Gonçalo J L Bernardes, Francisco Corzana
The Use of Fluoroproline in MUC1 Antigen Enables Efficient Detection of Antibodies in Patients with Prostate Cancer. Journal of the American Chemical Society 139 (50) (2017)

Gonçalo J L Bernardes.css-eqlu8i{font-size:small;padding-left:4px;} (G J L Bernardes)

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Gonçalo J L Bernardes (G J L Bernardes)