Georg Meisl

Loop profile ORCID

Publication Activity (10 Years)

Years Active: 2015-2024
Publications (10 Years): 90

Top Venues

ACS chemical neuroscience

Proceedings of the National Academy of Sciences of the United States of America

Chemical science

Nature chemical biology

University of Cambridge Sidney Sussex College

University of Cambridge (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

University of Cambridge Sidney Sussex College

United Kingdom

Research Fellow :: Department of Chemistry

University of Cambridge

United Kingdom

PostDoc :: Department of Chemistry

Universität Zurich Medizinische Fakultät Apr 01 2016 - May 31 2016

Switzerland

Visiting Researcher :: Department of Neuropathology

Education History

University of Cambridge

United Kingdom

PHD :: Department of Chemistry

Publications

Alexander J Dear, Xiangyu Teng, Sarah R Ball, Joshua Lewin, Robert I Horne, Daniel Clow, Alisdair Stevenson, Natasha Harper, Kim Yahya, Xiaoting Yang, Suzanne C Brewerton, John Thomson, Thomas C T Michaels, Sara Linse, Tuomas P J Knowles, Johnny Habchi, Georg Meisl
Molecular mechanism of α-synuclein aggregation on lipid membranes revealed. Chemical science 15 (19) (2024)
Danny D Sahtoe, Ewa A Andrzejewska, Hannah L Han, Enrico Rennella, Matthias M Schneider, Georg Meisl, Margaret Ahlrichs, Justin Decarreau, Hannah Nguyen, Alex Kang, Paul Levine, Mila Lamb, Xinting Li, Asim K Bera, Lewis E Kay, Tuomas P J Knowles, Julien S Baker
Design of amyloidogenic peptide traps. Nature chemical biology (2024)
Alexander J Dear, Dev Thacker, Stefan Wennmalm, Lei Ortigosa-Pascual, Ewa A Andrzejewska, Georg Meisl, Sara Linse, Tuomas P J Knowles
Aβ Oligomer Dissociation Is Catalyzed by Fibril Surfaces. ACS chemical neuroscience 15 (11) (2024)
Samo Curk, Johannes Krausser, Georg Meisl, Daan Frenkel, Sara Linse, Thomas C T Michaels, Tuomas P J Knowles, And Ela Šarić
Self-replication of A β 42 aggregates occurs on small and isolated fibril sites. Proceedings of the National Academy of Sciences of the United States of America 121 (7) (2024)
Jiapeng Wei, Georg Meisl, Alexander Dear, Matthijs Oosterhuis, Ronald Melki, Cecilia Emanuelsson, Sara Linse, Tuomas P J Knowles
Kinetic models reveal the interplay of protein production and aggregation. Chemical science 15 (22) (2024)
Alexander J Dear, Gonzalo A Garcia, Georg Meisl, Galen A Collins, Tuomas P J Knowles, Alfred L Goldberg
Maximum entropy determination of mammalian proteome dynamics. Proceedings of the National Academy of Sciences of the United States of America 121 (18) (2024)
Danny D Sahtoe, Ewa A Andrzejewska, Hannah L Han, Enrico Rennella, Matthias M Schneider, Georg Meisl, Margaret Ahlrichs, Justin Decarreau, Hannah Nguyen, Alex Kang, Paul Levine, Mila Lamb, Xinting Li, Asim K Bera, Lewis E Kay, Tuomas P J Knowles, Julien S Baker
Design of amyloidogenic peptide traps. Nature chemical biology 20 (8) (2024)
Alexander J Dear, Xiangyu Teng, Sarah R Ball, Joshua Lewin, Robert I Horne, Daniel Clow, Alisdair Stevenson, Natasha Harper, Kim Yahya, Xiaoting Yang, Suzanne C Brewerton, John Thomson, Thomas C T Michaels, Sara Linse, Tuomas P J Knowles, Johnny Habchi, Georg Meisl
Molecular mechanism of α-synuclein aggregation on lipid membranes revealed. Chemical science 15 (19) (2024)
Alexander J Dear, Gonzalo A Garcia, Georg Meisl, Galen A Collins, Tuomas P J Knowles, Alfred L Goldberg
Maximum entropy determination of mammalian proteome dynamics. Proceedings of the National Academy of Sciences of the United States of America 121 (18) (2024)
Danny D Sahtoe, Ewa A Andrzejewska, Hannah L Han, Enrico Rennella, Matthias M Schneider, Georg Meisl, Margaret Ahlrichs, Justin Decarreau, Hannah Nguyen, Alex Kang, Paul Levine, Mila Lamb, Xinting Li, Asim K Bera, Lewis E Kay, Tuomas P J Knowles, Julien S Baker
Design of amyloidogenic peptide traps. Nature chemical biology 20 (8) (2024)
Catherine K Xu, Georg Meisl, Ewa A Andrzejewska, Georg Krainer, Alexander J Dear, Marta Castellana-Cruz, Soma Turi, Irina A Edu, Giorgio Vivacqua, Raphaël P B Jacquat, William E Arter, Maria Grazia Spillantini, Christopher M Dobson, Sara Linse, Tuomas P J Knowles
α-Synuclein oligomers form by secondary nucleation. Nature communications 15 (1) (2024)
Samo Curk, Johannes Krausser, Georg Meisl, Daan Frenkel, Sara Linse, Thomas C T Michaels, Tuomas P J Knowles, And Ela Šarić
Self-replication of A β 42 aggregates occurs on small and isolated fibril sites. Proceedings of the National Academy of Sciences of the United States of America 121 (7) (2024)
Catherine K Xu, Georg Meisl, Ewa A Andrzejewska, Georg Krainer, Alexander J Dear, Marta Castellana-Cruz, Soma Turi, Irina A Edu, Giorgio Vivacqua, Raphaël P B Jacquat, William E Arter, Maria Grazia Spillantini, Christopher M Dobson, Sara Linse, Tuomas P J Knowles
α-Synuclein oligomers form by secondary nucleation. Nature communications 15 (1) (2024)
Alexander J Dear, Dev Thacker, Stefan Wennmalm, Lei Ortigosa-Pascual, Ewa A Andrzejewska, Georg Meisl, Sara Linse, Tuomas P J Knowles
Aβ Oligomer Dissociation Is Catalyzed by Fibril Surfaces. ACS chemical neuroscience 15 (11) (2024)
Alexander J Dear, Georg Meisl, Christopher G Taylor, Umberto Capasso Palmiero, Susanne Nordby Stubbe, Qian Liu, Paolo Arosio, Sara Linse, Tuomas P J Knowles, Maria Andreasen
Surface effects on functional amyloid formation. Nanoscale (2024)
Samo Curk, Johannes Krausser, Georg Meisl, Daan Frenkel, Sara Linse, Thomas C T Michaels, Tuomas P J Knowles, And Ela Šarić
Self-replication of A β 42 aggregates occurs on small and isolated fibril sites. Proceedings of the National Academy of Sciences of the United States of America 121 (7) (2024)
Alexander J Dear, Gonzalo A Garcia, Georg Meisl, Galen A Collins, Tuomas P J Knowles, Alfred L Goldberg
Maximum entropy determination of mammalian proteome dynamics. Proceedings of the National Academy of Sciences of the United States of America 121 (18) (2024)
Samo Curk, Johannes Krausser, Georg Meisl, Daan Frenkel, Sara Linse, Thomas C T Michaels, Tuomas P J Knowles, And Ela Šarić
Self-replication of A β 42 aggregates occurs on small and isolated fibril sites. Proceedings of the National Academy of Sciences of the United States of America 121 (7) (2024)
Alexander J Dear, Georg Meisl, Christopher G Taylor, Umberto Capasso Palmiero, Susanne Nordby Stubbe, Qian Liu, Paolo Arosio, Sara Linse, Tuomas P J Knowles, Maria Andreasen
Surface effects on functional amyloid formation. Nanoscale 16 (34) (2024)
Georg Meisl
The thermodynamics of neurodegenerative disease. Biophysics reviews 5 (1) (2024)
Alexander J Dear, Dev Thacker, Stefan Wennmalm, Lei Ortigosa-Pascual, Ewa A Andrzejewska, Georg Meisl, Sara Linse, Tuomas P J Knowles
Aβ Oligomer Dissociation Is Catalyzed by Fibril Surfaces. ACS chemical neuroscience 15 (11) (2024)
Jiapeng Wei, Georg Meisl, Alexander Dear, Matthijs Oosterhuis, Ronald Melki, Cecilia Emanuelsson, Sara Linse, Tuomas P J Knowles
Kinetic models reveal the interplay of protein production and aggregation. Chemical science 15 (22) (2024)
Samo Curk, Johannes Krausser, Georg Meisl, Daan Frenkel, Sara Linse, Thomas C T Michaels, Tuomas P J Knowles, And Ela Šarić
Self-replication of A β 42 aggregates occurs on small and isolated fibril sites. Proceedings of the National Academy of Sciences of the United States of America 121 (7) (2024)
Alexander J Dear, Dev Thacker, Stefan Wennmalm, Lei Ortigosa-Pascual, Ewa A Andrzejewska, Georg Meisl, Sara Linse, Tuomas P J Knowles
Aβ Oligomer Dissociation Is Catalyzed by Fibril Surfaces. ACS chemical neuroscience 15 (11) (2024)
Alexander J Dear, Dev Thacker, Stefan Wennmalm, Lei Ortigosa-Pascual, Ewa A Andrzejewska, Georg Meisl, Sara Linse, Tuomas P J Knowles
Aβ Oligomer Dissociation Is Catalyzed by Fibril Surfaces. ACS chemical neuroscience 15 (11) (2024)
Danny D Sahtoe, Ewa A Andrzejewska, Hannah L Han, Enrico Rennella, Matthias M Schneider, Georg Meisl, Margaret Ahlrichs, Justin Decarreau, Hannah Nguyen, Alex Kang, Paul Levine, Mila Lamb, Xinting Li, Asim K Bera, Lewis E Kay, Tuomas P J Knowles, Julien S Baker
Design of amyloidogenic peptide traps. Nature chemical biology 20 (8) (2024)
Georg Meisl
The thermodynamics of neurodegenerative disease. Biophysics reviews 5 (1) (2024)
Alexander J Dear, Dev Thacker, Stefan Wennmalm, Lei Ortigosa-Pascual, Ewa A Andrzejewska, Georg Meisl, Sara Linse, Tuomas P J Knowles
Aβ Oligomer Dissociation Is Catalyzed by Fibril Surfaces. ACS chemical neuroscience (2024)
Alexander J Dear, Georg Meisl, Christopher G Taylor, Umberto Capasso Palmiero, Susanne Nordby Stubbe, Qian Liu, Paolo Arosio, Sara Linse, Tuomas P J Knowles, Maria Andreasen
Surface effects on functional amyloid formation. Nanoscale 16 (34) (2024)
Robert I Horne, Michael A Metrick, Wing Man, Dillon J Rinauro, Z Faidon Brotzakis, Sean Chia, Georg Meisl, Christopher M Dobson
Secondary Processes Dominate the Quiescent, Spontaneous Aggregation of α-Synuclein at Physiological pH with Sodium Salts. ACS chemical neuroscience (2023)
Chenrong Yu, Spencer L Nelson, Georg Meisl, Rodolfo Ghirlando, Lalit Deshmukh
Phase Separation and Fibrillization of Human Annexin A7 Are Mediated by Its Proline-Rich Domain. Biochemistry (2023)
Viola Denninger, Catherine K Xu, Georg Meisl, Alexey S Morgunov, Sebastian Fiedler, Alison Ilsley, Marc Emmenegger, Anisa Y Malik, Monika A Piziorska, Matthias M Schneider, Sean R A Devenish, Vasilis Kosmoliaptsis, Adriano Aguzzi, Heike Fiegler, Tuomas P J Knowles
Microfluidic Antibody Affinity Profiling Reveals the Role of Memory Reactivation and Cross-Reactivity in the Defense Against SARS-CoV-2. ACS infectious diseases 8 (4) (2022)
Sarah R Ball, Julius S P Adamson, Michael A Sullivan, Manuela R Zimmermann, Victor Lo, Maximo Sanz-Hernandez, Xiaofan Jiang, Ann H Kwan, André D J Mckenzie, Eryn L Werry, Tuomas P J Knowles, Michael Kassiou, Georg Meisl, Matthew H Todd, Peter J Rutledge, Margaret Sunde
Perphenazine-Macrocycle Conjugates Rapidly Sequester the Aβ42 Monomer and Prevent Formation of Toxic Oligomers and Amyloid. ACS chemical neuroscience 14 (1) (2022)
Karl J Frontzek, Marco Bardelli, Assunta Senatore, Anna Henzi, Regina R Reimann, Seden Bedir, Marika Marino, Rohanah Hussain, Simon Jurt, Georg Meisl, Mattia Pedotti, Federica Mazzola, Giuliano Siligardi, Oliver Zerbe, Marco Losa, Tuomas P J Knowles, Asvin Lakkaraju, Caihong Zhu, Petra Schwarz, Simone Hornemann, Matthew G Holt, Luca Simonelli, Luca Varani, Adriano Aguzzi
A conformational switch controlling the toxicity of the prion protein. Nature structural & molecular biology 29 (8) (2022)
Sarah R Ball, Julius S P Adamson, Michael A Sullivan, Manuela R Zimmermann, Victor Lo, Maximo Sanz-Hernandez, Xiaofan Jiang, Ann H Kwan, André D J Mckenzie, Eryn L Werry, Tuomas P J Knowles, Michael Kassiou, Georg Meisl, Matthew H Todd, Peter J Rutledge, Margaret Sunde
Perphenazine-Macrocycle Conjugates Rapidly Sequester the Aβ42 Monomer and Prevent Formation of Toxic Oligomers and Amyloid. ACS chemical neuroscience (2022)
Catherine K Xu, Marta Castellana-Cruz, Serene W Chen, Zhen Du, Georg Meisl, Aviad Levin, Benedetta Mannini, Laura S Itzhaki, Tuomas P J Knowles, Christopher M Dobson, Nunilo Cremades, Janet R Kumita
The Pathological G51D Mutation in Alpha-Synuclein Oligomers Confers Distinct Structural Attributes and Cellular Toxicity. Molecules (Basel, Switzerland) 27 (4) (2022)
Azad Farzadfard, Jannik Nedergaard Pedersen, Georg Meisl, Arun Kumar Somavarapu, Parvez Alam, Louise Goksøyr, Morten Agertoug Nielsen, Adam Frederik Sander, Tuomas P J Knowles, Jan Skov Pedersen, Daniel Erik Otzen
The C-terminal tail of α-synuclein protects against aggregate replication but is critical for oligomerization. Communications biology 5 (1) (2022)
Sarah R Ball, Julius S P Adamson, Michael A Sullivan, Manuela R Zimmermann, Victor Lo, Maximo Sanz-Hernandez, Xiaofan Jiang, Ann H Kwan, André D J Mckenzie, Eryn L Werry, Tuomas P J Knowles, Michael Kassiou, Georg Meisl, Matthew H Todd, Peter J Rutledge, Margaret Sunde
Perphenazine-Macrocycle Conjugates Rapidly Sequester the Aβ42 Monomer and Prevent Formation of Toxic Oligomers and Amyloid. ACS chemical neuroscience 14 (1) (2022)
Sarah R Ball, Julius S P Adamson, Michael A Sullivan, Manuela R Zimmermann, Victor Lo, Maximo Sanz-Hernandez, Xiaofan Jiang, Ann H Kwan, André D J Mckenzie, Eryn L Werry, Tuomas P J Knowles, Michael Kassiou, Georg Meisl, Matthew H Todd, Peter J Rutledge, Margaret Sunde
Perphenazine-Macrocycle Conjugates Rapidly Sequester the Aβ42 Monomer and Prevent Formation of Toxic Oligomers and Amyloid. ACS chemical neuroscience 14 (1) (2022)
Georg Meisl, Catherine K Xu, Jonathan D Taylor, Thomas C T Michaels, Aviad Levin, Daniel Erik Otzen, David Klenerman, Stephen J Matthews, Sara Linse, Maria Andreasen, Tuomas P J Knowles
Uncovering the universality of self-replication in protein aggregation and its link to disease. Science advances 8 (32) (2022)
Sarah R Ball, Julius S P Adamson, Michael A Sullivan, Manuela R Zimmermann, Victor Lo, Maximo Sanz-Hernandez, Xiaofan Jiang, Ann H Kwan, André D J Mckenzie, Eryn L Werry, Tuomas P J Knowles, Michael Kassiou, Georg Meisl, Matthew H Todd, Peter J Rutledge, Margaret Sunde
Perphenazine-Macrocycle Conjugates Rapidly Sequester the Aβ42 Monomer and Prevent Formation of Toxic Oligomers and Amyloid. ACS chemical neuroscience 14 (1) (2022)
Sarah R Ball, Julius S P Adamson, Michael A Sullivan, Manuela R Zimmermann, Victor Lo, Maximo Sanz-Hernandez, Xiaofan Jiang, Ann H Kwan, André D J Mckenzie, Eryn L Werry, Tuomas P J Knowles, Michael Kassiou, Georg Meisl, Matthew H Todd, Peter J Rutledge, Margaret Sunde
Perphenazine-Macrocycle Conjugates Rapidly Sequester the Aβ42 Monomer and Prevent Formation of Toxic Oligomers and Amyloid. ACS chemical neuroscience 14 (1) (2022)
Sarah R Ball, Julius S P Adamson, Michael A Sullivan, Manuela R Zimmermann, Victor Lo, Maximo Sanz-Hernandez, Xiaofan Jiang, Ann H Kwan, André D J Mckenzie, Eryn L Werry, Tuomas P J Knowles, Michael Kassiou, Georg Meisl, Matthew H Todd, Peter J Rutledge, Margaret Sunde
Perphenazine-Macrocycle Conjugates Rapidly Sequester the Aβ42 Monomer and Prevent Formation of Toxic Oligomers and Amyloid. ACS chemical neuroscience 14 (1) (2022)
Jason C Sang, Eric Hidari, Georg Meisl, Rohan T Ranasinghe, Maria Grazia Spillantini, David Klenerman
Super-resolution imaging reveals α-synuclein seeded aggregation in SH-SY5Y cells. Communications biology 4 (1) (2021)
Georg Meisl, Eric Hidari, Kieren Allinson, Timothy Rittman, Sarah L DeVos, Justin S Sanchez, Catherine K Xu, Karen E Duff, Keith A Johnson, James Benedict Rowe, Bradley T Hyman, Tuomas P J Knowles, David Klenerman
In vivo rate-determining steps of tau seed accumulation in Alzheimer's disease. Science advances 7 (44) (2021)
Georg Meisl, Timothy Kurt, Itzel Condado-Morales, Cyrus Bett, Silvia Sorce, Mario Nuvolone, Thomas C T Michaels, Daniel Heinzer, Merve Avar, Samuel I A Cohen, Simone Hornemann, Adriano Aguzzi, Christopher M Dobson, Christina J Sigurdson, Tuomas P J Knowles
Scaling analysis reveals the mechanism and rates of prion replication in vivo. Nature structural & molecular biology 28 (4) (2021)
Dor Zaguri, Manuela R Zimmermann, Georg Meisl, Aviad Levin, Sigal Rencus-Lazar, Tuomas P J Knowles, Ehud Gazit
Kinetic and Thermodynamic Driving Factors in the Assembly of Phenylalanine-Based Modules. ACS nano (2021)
Sebastian Fiedler, Monika A Piziorska, Viola Denninger, Alexey S Morgunov, Alison Ilsley, Anisa Y Malik, Matthias M Schneider, Sean R A Devenish, Georg Meisl, Vasilis Kosmoliaptsis, Adriano Aguzzi, Heike Fiegler, Tuomas P J Knowles
Antibody Affinity Governs the Inhibition of SARS-CoV-2 Spike/ACE2 Binding in Patient Serum. ACS infectious diseases 7 (8) (2021)
Eva Illes-Toth, Georg Meisl, Don L Rempel, Tuomas P J Knowles, Michael L Gross
Pulsed Hydrogen-Deuterium Exchange Reveals Altered Structures and Mechanisms in the Aggregation of Familial Alzheimer's Disease Mutants. ACS chemical neuroscience 12 (11) (2021)
Manuela R Zimmermann, Subhas C Bera, Georg Meisl, Sourav Dasadhikari, Shamasree Ghosh, Sara Linse, Kanchan Garai, Tuomas P J Knowles
Mechanism of Secondary Nucleation at the Single Fibril Level from Direct Observations of Aβ42 Aggregation. Journal of the American Chemical Society 143 (40) (2021)
Tom Scheidt, Jacqueline A Carozza, Carl C Kolbe, Francesco Antonio Aprile, Olga Tkachenko, Mathias M J Bellaiche, Georg Meisl, Quentin A E Peter, Therese W Herling, Samuel Ness, Marta Castellana-Cruz, Justin L P Benesch, Christopher M Dobson, Christopher M Dobson, Paolo Arosio, Tuomas P J Knowles
The binding of the small heat-shock protein αB-crystallin to fibrils of α-synuclein is driven by entropic forces. Proceedings of the National Academy of Sciences of the United States of America 118 (38) (2021)
Tessa Sinnige, Georg Meisl, Thomas C T Michaels, Christopher M Dobson, Tuomas P J Knowles, Richard I Morimoto
Kinetic analysis reveals that independent nucleation events determine the progression of polyglutamine aggregation in C. elegans. Proceedings of the National Academy of Sciences of the United States of America 118 (11) (2021)
Diana C Rodriguez Camargo, Eimantas Sileikis, Sean Chia, Emil Axell, Katja Bernfur, Rodrigo L Cataldi, Samuel I A Cohen, Georg Meisl, Johnny Habchi, Tuomas P J Knowles, Christopher M Dobson, Sara Linse
Proliferation of Tau 304-380 Fragment Aggregates through Autocatalytic Secondary Nucleation. ACS chemical neuroscience 12 (23) (2021)
Karl J Frontzek, Manfredi Carta, Marco Losa, Mirka Epskamp, Georg Meisl, Alice Anane, Jean-Philippe Brandel, Ulrike Camenisch, Joaquín Castilla, Stéphane Haïk, Tuomas P J Knowles, Ewald Lindner, Andreas Lutterotti, Eric Vallabh Minikel, Ignazio Roiter, Jiri G Safar, Raquel Sanchez-Valle, Dana Žáková, Simone Hornemann, Adriano Aguzzi, null null
Autoantibodies against the prion protein in individuals with PRNP mutations. Neurology 95 (14) (2020)
Dev Thacker, Kalyani Sanagavarapu, Birgitta Frohm, Georg Meisl, Tuomas P J Knowles, Sara Linse
The role of fibril structure and surface hydrophobicity in secondary nucleation of amyloid fibrils. Proceedings of the National Academy of Sciences of the United States of America 117 (41) (2020)
Alexander J Dear, Thomas C T Michaels, Georg Meisl, David Klenerman, Si Wu, Sarah Perrett, Sara Linse, Christopher M Dobson, Tuomas P J Knowles
Kinetic diversity of amyloid oligomers. Proceedings of the National Academy of Sciences of the United States of America 117 (22) (2020)
Thomas C T Michaels, And Ela Šarić, Samo Curk, Katja Bernfur, Paolo Arosio, Georg Meisl, Alexander J Dear, Samuel I A Cohen, Christopher M Dobson, Christopher M Dobson, Sara Linse, Tuomas P J Knowles
Dynamics of oligomer populations formed during the aggregation of Alzheimer's Aβ42 peptide. Nature chemistry 12 (5) (2020)
Mattias Törnquist, Risto Cukalevski, Ulrich Weininger, Georg Meisl, Tuomas P J Knowles, Thom Leiding, Anders Malmendal, Mikael Akke, Sara Linse
Ultrastructural evidence for self-replication of Alzheimer-associated Aβ42 amyloid along the sides of fibrils. Proceedings of the National Academy of Sciences of the United States of America 117 (21) (2020)
Alexander J Dear, Georg Meisl, And Ela Šarić, Thomas C T Michaels, Magnus Kjaergaard, Sara Linse, Tuomas P J Knowles
Identification of on- and off-pathway oligomers in amyloid fibril formation. Chemical science 11 (24) (2020)
Thomas C T Michaels, And Ela Šarić, Georg Meisl, Gabriella T Heller, Samo Curk, Paolo Arosio, Sara Linse, Christopher M Dobson, Christopher M Dobson, Tuomas P J Knowles
Thermodynamic and kinetic design principles for amyloid-aggregation inhibitors. Proceedings of the National Academy of Sciences of the United States of America 117 (39) (2020)
Jonathan Pansieri, Igor A Iashchishyn, Hussein Fakhouri, Lucija Ostojić, Mantas Malisauskas, Greta Šneiderienė, Vytautas Smirnovas, Matthias M Schneider, Tom Scheidt, Catherine K Xu, Georg Meisl, Tuomas P J Knowles, Ehud Gazit, Rodolphe Antoine, Ludmilla A Morozova-Roche
Templating S100A9 amyloids on Aβ fibrillar surfaces revealed by charge detection mass spectrometry, microscopy, kinetic and microfluidic analyses. Chemical science 11 (27) (2020)
Sara Linse, Tom Scheidt, Katja Bernfur, Christopher M Dobson, Christopher M Dobson, Samuel I A Cohen, Eimantas Sileikis, Martin Lundqvist, Fang Qian, Tiernan T O'Malley, Thierry Bussiere, Paul H Weinreb, Catherine K Xu, Georg Meisl, Sean R A Devenish, Tuomas P J Knowles, Oskar Hansson
Kinetic fingerprints differentiate the mechanisms of action of anti-Aβ antibodies. Nature structural & molecular biology 27 (12) (2020)
Seyyed Abolghasem Ghadami, Sean Chia, Francesco Simone Ruggeri, Georg Meisl, Francesco Bemporad, Johnny Habchi, Roberta Cascella, Christopher M Dobson, Christopher M Dobson, Tuomas P J Knowles, Fabrizio Chiti
Transthyretin Inhibits Primary and Secondary Nucleations of Amyloid-β Peptide Aggregation and Reduces the Toxicity of Its Oligomers. Biomacromolecules 21 (3) (2020)
Alexander J Dear, Georg Meisl, Thomas C T Michaels, Manuela R Zimmermann, Sara Linse, Tuomas P J Knowles
The catalytic nature of protein aggregation. The Journal of chemical physics 152 (4) (2020)
Jiangtao Zhou, Francesco S Ruggeri, Manuela R Zimmermann, Georg Meisl, Giovanni Longo, Sergey K Sekatskii, Tuomas P J Knowles, Giovanni Dietler
Effects of sedimentation, microgravity, hydrodynamic mixing and air-water interface on α-synuclein amyloid formation. Chemical science 11 (14) (2020)
Francesco Simone Ruggeri, Patrick Flagmeier, Janet R Kumita, Georg Meisl, Dimitri Y Chirgadze, Marie N Bongiovanni, Tuomas P J Knowles, Christopher M Dobson
The Influence of Pathogenic Mutations in α-Synuclein on Biophysical and Structural Characteristics of Amyloid Fibrils. ACS nano 14 (5) (2020)
Angus Lau, Raphaella W L So, Heather H C Lau, Jason C Sang, Alejandro Iván Ruíz Riquelme, Shelaine C Fleck, Erica Stuart, Sindhu Menon, Naomi P Visanji, Georg Meisl, Rania Faidi, Maria M Marano, Cian Schmitt-Ulms, Zhilan Wang, Paul E Fraser, Anurag Tandon, Bradley T Hyman, Holger Wille, Martin Ingelsson, David Klenerman, Joel C Watts
α-Synuclein strains target distinct brain regions and cell types. Nature neuroscience 23 (1) (2019)
Carlos Perez, Tatiana Miti, Filip Hasecke, Georg Meisl, Wolfgang Hoyer, Martin Muschol, Ghanim Ullah
Mechanism of Fibril and Soluble Oligomer Formation in Amyloid Beta and Hen Egg White Lysozyme Proteins. The journal of physical chemistry. B 123 (27) (2019)
Kalyani Sanagavarapu, Elisabeth Nüske, Irem Nasir, Georg Meisl, Jasper N Immink, Pietro Sormanni, Christopher M Dobson, Tuomas P J Knowles, Anders Malmendal, Celia Cabaleiro-Lago, Sara Linse
A method of predicting the in vitro fibril formation propensity of Aβ40 mutants based on their inclusion body levels in E. coli. Scientific reports 9 (1) (2019)
Jason C Sang, Ji-Eun Lee, Alexander J Dear, Suman De, Georg Meisl, Alana M Thackray, Raymond Bujdoso, Tuomas P J Knowles, David Klenerman
Direct observation of prion protein oligomer formation reveals an aggregation mechanism with multiple conformationally distinct species. Chemical science 10 (17) (2019)
Tanja Weiffert, Georg Meisl, Patrick Flagmeier, Suman De, Christopher J R Dunning, Birgitta Frohm, Henrik Zetterberg, Kaj Blennow, Erik Portelius, David Klenerman, Christopher M Dobson, Tuomas P J Knowles, Sara Linse
Increased Secondary Nucleation Underlies Accelerated Aggregation of the Four-Residue N-Terminally Truncated Aβ42 Species Aβ5-42. ACS chemical neuroscience 10 (5) (2019)
Ryan Limbocker, Sean Chia, Francesco S Ruggeri, Michele Perni, Roberta Cascella, Gabriella T Heller, Georg Meisl, Benedetta Mannini, Johnny Habchi, Thomas C T Michaels, Pavan K Challa, Minkoo Ahn, Samuel T Casford, Nilumi Fernando, Catherine K Xu, Nina D Kloss, Samuel I A Cohen, Janet R Kumita, Cristina Cecchi, Michael Zasloff, Sara Linse, Tuomas P J Knowles, Fabrizio Chiti, Michele Vendruscolo, Christopher M Dobson
Trodusquemine enhances Aβ42 aggregation but suppresses its toxicity by displacing oligomers from cell membranes. Nature communications 10 (1) (2019)
Rebecca Frankel, Mattias Törnquist, Georg Meisl, Oskar Hansson, Ulf Andreasson, Henrik Zetterberg, Kaj Blennow, Birgitta Frohm, Tommy Cedervall, Tuomas P J Knowles, Thom Leiding, Sara Linse
Autocatalytic amplification of Alzheimer-associated Aβ42 peptide aggregation in human cerebrospinal fluid. Communications biology 2 (2019)
Zahra Najarzadeh, Hossein Mohammad-Beigi, Jannik Nedergaard Pedersen, Gunna Christiansen, Thorbjørn Vincent Sønderby, Seyed Abbas Shojaosadati, Dina Morshedi, Kristian Stro Mgaard, Georg Meisl, Duncan Sutherland, Jan Skov Pedersen, Daniel Erik Otzen
Plant Polyphenols Inhibit Functional Amyloid and Biofilm Formation in Pseudomonas Strains by Directing Monomers to Off-Pathway Oligomers. Biomolecules 9 (11) (2019)
Yuewen Zhang, Emma V Yates, Liu Hong, Kadi Liis Saar, Georg Meisl, Christopher M Dobson, Tuomas P J Knowles
On-chip measurements of protein unfolding from direct observations of micron-scale diffusion. Chemical science 9 (14) (2018)
Hongze Gang, Céline Galvagnion, Georg Meisl, Thomas Müller, Manuela Pfammatter, Alexander K Buell, Aviad Levin, Christopher M Dobson, Bozhong Mu, Tuomas P J Knowles
Microfluidic Diffusion Platform for Characterizing the Sizes of Lipid Vesicles and the Thermodynamics of Protein-Lipid Interactions. Analytical chemistry 90 (5) (2018)
Michele Perni, Patrick Flagmeier, Ryan Limbocker, Roberta Cascella, Francesco Antonio Aprile, Céline Galvagnion, Gabriella T Heller, Georg Meisl, Serene W Chen, Janet R Kumita, Pavan Kumar Challa, Julius B Kirkegaard, Samuel I A Cohen, Benedetta Mannini, Denise Barbut, Ellen A A Nollen, Cristina Cecchi, Nunilo Cremades, Tuomas P J Knowles, Fabrizio Chiti, Michael Zasloff, Christopher M Dobson, Christopher M Dobson
Multistep Inhibition of α-Synuclein Aggregation and Toxicity in Vitro and in Vivo by Trodusquemine. ACS chemical biology 13 (8) (2018)
Xiaoting Yang, Georg Meisl, Birgitta Frohm, Eva Thulin, Tuomas P J Knowles, Sara Linse
On the role of sidechain size and charge in the aggregation of Aβ42 with familial mutations. Proceedings of the National Academy of Sciences of the United States of America 115 (26) (2018)
Franziska Kundel, Liu Hong, Benjamin Falcon, William A McEwan, Thomas C T Michaels, Georg Meisl, Noemi Esteras, Andrey Y Abramov, Tuomas P J Knowles, Michel Goedert, David Klenerman
Measurement of Tau Filament Fragmentation Provides Insights into Prion-like Spreading. ACS chemical neuroscience 9 (6) (2018)
Jason C Sang, Georg Meisl, Alana M Thackray, Liu Hong, Aleks Ponjavic, Tuomas P J Knowles, Raymond Bujdoso, David Klenerman
Direct Observation of Murine Prion Protein Replication in Vitro. Journal of the American Chemical Society 140 (44) (2018)
Magnus Kjaergaard, Alexander J Dear, Franziska Kundel, Seema Qamar, Georg Meisl, Tuomas P J Knowles, David Klenerman
Oligomer Diversity during the Aggregation of the Repeat Region of Tau. ACS chemical neuroscience 9 (12) (2018)
James W P Brown, Georg Meisl, Tuomas P J Knowles, Alexander K Buell, Christopher M Dobson, Céline Galvagnion
Kinetic barriers to α-synuclein protofilament formation and conversion into mature fibrils. Chemical communications (Cambridge, England) 54 (56) (2018)
Christopher G Taylor, Georg Meisl, Mathew H Horrocks, Henrik Zetterberg, Tuomas P J Knowles, David Klenerman
Extrinsic Amyloid-Binding Dyes for Detection of Individual Protein Aggregates in Solution. Analytical chemistry 90 (17) (2018)
Filip Hasecke, Tatiana Miti, Carlos Perez, Jeremy Barton, Daniel Schölzel, Lothar Gremer, Clara S R Grüning, Garrett Matthews, Georg Meisl, Tuomas P J Knowles, Dieter Willbold, Philipp Neudecker, Henrike Heise, Ghanim Ullah, Wolfgang Hoyer, Martin Muschol
Origin of metastable oligomers and their effects on amyloid fibril self-assembly. Chemical science 9 (27) (2018)
Anna Munke, Jonas Persson, Tanja Weiffert, Erwin De Genst, Georg Meisl, Paolo Arosio, Anna Carnerup, Christopher M Dobson, Michele Vendruscolo, Tuomas P J Knowles, Sara Linse
Phage display and kinetic selection of antibodies that specifically inhibit amyloid self-replication. Proceedings of the National Academy of Sciences of the United States of America 114 (25) (2017)
Georg Meisl, Luke Rajah, Samuel A I Cohen, Manuela Pfammatter, And Ela Šarić, Erik Hellstrand, Alexander K Buell, Adriano Aguzzi, Sara Linse, Michele Vendruscolo, Christopher M Dobson, Tuomas P J Knowles
Scaling behaviour and rate-determining steps in filamentous self-assembly. Chemical science 8 (10) (2017)
Manuela Pfammatter, Maria Andreasen, Georg Meisl, Christopher G Taylor, Jozef Adamcik, Sreenath Bolisetty, Antoni Sánchez-Ferrer, David Klenerman, Christopher M Dobson, Raffaele Mezzenga, Tuomas P J Knowles, Adriano Aguzzi, Simone Hornemann
Absolute Quantification of Amyloid Propagons by Digital Microfluidics. Analytical chemistry 89 (22) (2017)
Michele Perni, Céline Galvagnion, Alexander Maltsev, Georg Meisl, Martin B D Müller, Pavan K Challa, Julius B Kirkegaard, Patrick Flagmeier, Samuel I A Cohen, Roberta Cascella, Serene W Chen, Ryan Limbocker, Pietro Sormanni, Gabriella T Heller, Francesco A Aprile, Nunilo Cremades, Cristina Cecchi, Fabrizio Chiti, Ellen A A Nollen, Tuomas P J Knowles, Michele Vendruscolo, Adriaan Bax, Michael Zasloff, Christopher M Dobson
A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity. Proceedings of the National Academy of Sciences of the United States of America 114 (6) (2017)
Georg Meisl, Xiaoting Yang, Christopher M Dobson, Sara Linse, Tuomas P J Knowles
Modulation of electrostatic interactions to reveal a reaction network unifying the aggregation behaviour of the Aβ42 peptide and its variants. Chemical science 8 (6) (2017)
Patrick Flagmeier, Georg Meisl, Michele Vendruscolo, Tuomas P J Knowles, Christopher M Dobson, Alexander K Buell, Céline Galvagnion
Mutations associated with familial Parkinson's disease alter the initiation and amplification steps of α-synuclein aggregation. Proceedings of the National Academy of Sciences of the United States of America 113 (37) (2016)
Risto Cukalevski, Xiaoting Yang, Georg Meisl, Ulrich Weininger, Katja Bernfur, Birgitta Frohm, Tuomas P J Knowles, Sara Linse
The Aβ40 and Aβ42 peptides self-assemble into separate homomolecular fibrils in binary mixtures but cross-react during primary nucleation. Chemical science 6 (7) (2015)

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Georg Meisl