Seth A Darst

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 45

Top Topics

Electron Microscopy

Gene Expression

Structural Basis

Mycobacterium Tuberculosis

Top Venues

Proceedings of the National Academy of Sciences of the United States of America

Nature structural & molecular biology

This page only lists publications with an associated author ORCID identifier.

Publications

Ruth M Saecker, Andreas U Mueller, Brandon F Malone, James Chen, William C Budell, Venkata P Dandey, Kashyap Maruthi, Joshua H Mendez, Nina Molina, Edward T Eng, Laura Y Yen, Clinton S Potter, Bridget Carragher, Seth A Darst
Early intermediates in bacterial RNA polymerase promoter melting visualized by time-resolved cryo-electron microscopy. bioRxiv : the preprint server for biology (2024)
Ruth M Saecker, Andreas U Mueller, Brandon Malone, James Chen, William C Budell, Venkata P Dandey, Kashyap Maruthi, Joshua H Mendez, Nina Molina, Edward T Eng, Laura Y Yen, Clinton S Potter, Bridget Carragher, Seth A Darst
Early intermediates in bacterial RNA polymerase promoter melting visualized by time-resolved cryo-electron microscopy. Nature structural & molecular biology (2024)
Ruth M Saecker, Andreas U Mueller, Brandon F Malone, James Chen, William C Budell, Venkata P Dandey, Kashyap Maruthi, Joshua H Mendez, Nina Molina, Edward T Eng, Laura Y Yen, Clinton S Potter, Bridget Carragher, Seth A Darst
Early intermediates in bacterial RNA polymerase promoter melting visualized by time-resolved cryo-electron microscopy. bioRxiv : the preprint server for biology (2024)
Ruth M Saecker, Andreas U Mueller, Brandon Malone, James Chen, William C Budell, Venkata P Dandey, Kashyap Maruthi, Joshua H Mendez, Nina Molina, Edward T Eng, Laura Y Yen, Clinton S Potter, Bridget Carragher, Seth A Darst
Early intermediates in bacterial RNA polymerase promoter melting visualized by time-resolved cryo-electron microscopy. Nature structural & molecular biology (2024)
Ruth M Saecker, Andreas U Mueller, Brandon F Malone, James Chen, William C Budell, Venkata P Dandey, Kashyap Maruthi, Joshua H Mendez, Nina Molina, Edward T Eng, Laura Y Yen, Clinton S Potter, Bridget Carragher, Seth A Darst
Early intermediates in bacterial RNA polymerase promoter melting visualized by time-resolved cryo-electron microscopy. bioRxiv : the preprint server for biology (2024)
Jin Young Kang, Tatiana V Mishanina, Yu Bao, James Chen, Eliza Llewellyn, James Liu, Seth A Darst, Robert Landick
An ensemble of interconverting conformations of the elemental paused transcription complex creates regulatory options. Proceedings of the National Academy of Sciences of the United States of America 120 (8) (2023)
Brandon F Malone, Jason K Perry, Paul Dominic B Olinares, Hery W Lee, James Chen, Todd C Appleby, Joy Y Feng, John P Bilello, Honkit Ng, Johanna Sotiris, Mark Ebrahim, Eugene Y D Chua, Joshua H Mendez, Edward T Eng, Robert Landick, Matthias Götte, Brian T Chait, Elizabeth A Campbell, Seth A Darst
Structural basis for substrate selection by the SARS-CoV-2 replicase. Nature (2023)
Brandon F Malone, Jason K Perry, Paul Dominic B Olinares, Hery W Lee, James Chen, Todd C Appleby, Joy Y Feng, John P Bilello, Honkit Ng, Johanna Sotiris, Mark Ebrahim, Eugene Y D Chua, Joshua H Mendez, Edward T Eng, Robert Landick, Matthias Götte, Brian T Chait, Elizabeth A Campbell, Seth A Darst
Structural basis for substrate selection by the SARS-CoV-2 replicase. Nature (2023)
Jin Young Kang, Tatiana V Mishanina, Yu Bao, James Chen, Eliza Llewellyn, James Liu, Seth A Darst, Robert Landick
An ensemble of interconverting conformations of the elemental paused transcription complex creates regulatory options. Proceedings of the National Academy of Sciences of the United States of America 120 (8) (2023)
Brandon F Malone, Jason K Perry, Paul Dominic B Olinares, Hery W Lee, James Chen, Todd C Appleby, Joy Y Feng, John P Bilello, Honkit Ng, Johanna Sotiris, Mark Ebrahim, Eugene Y D Chua, Joshua H Mendez, Edward T Eng, Robert Landick, Matthias Götte, Brian T Chait, Elizabeth A Campbell, Seth A Darst
Structural basis for substrate selection by the SARS-CoV-2 replicase. Nature 614 (7949) (2023)
Jin Young Kang, Tatiana V Mishanina, Yu Bao, James Chen, Eliza Llewellyn, James Liu, Seth A Darst, Robert Landick
An ensemble of interconverting conformations of the elemental paused transcription complex creates regulatory options. Proceedings of the National Academy of Sciences of the United States of America 120 (8) (2023)
Brandon F Malone, Jason K Perry, Paul Dominic B Olinares, Hery W Lee, James Chen, Todd C Appleby, Joy Y Feng, John P Bilello, Honkit Ng, Johanna Sotiris, Mark Ebrahim, Eugene Y D Chua, Joshua H Mendez, Edward T Eng, Robert Landick, Matthias Götte, Brian T Chait, Elizabeth A Campbell, Seth A Darst
Structural basis for substrate selection by the SARS-CoV-2 replicase. Nature 614 (7949) (2023)
Jin Young Kang, Tatiana V Mishanina, Yu Bao, James Chen, Eliza Llewellyn, James Liu, Seth A Darst, Robert Landick
An ensemble of interconverting conformations of the elemental paused transcription complex creates regulatory options. Proceedings of the National Academy of Sciences of the United States of America 120 (8) (2023)
Andreas U Mueller, James Chen, Mengyu Wu, Courtney Chiu, B Tracy Nixon, Elizabeth A Campbell, Seth A Darst
A general mechanism for transcription bubble nucleation in bacteria. Proceedings of the National Academy of Sciences of the United States of America 120 (14) (2023)
Andreas U Mueller, James Chen, Mengyu Wu, Courtney Chiu, B Tracy Nixon, Elizabeth A Campbell, Seth A Darst
A general mechanism for transcription bubble nucleation in bacteria. Proceedings of the National Academy of Sciences of the United States of America 120 (14) (2023)
Brandon F Malone, Jason K Perry, Paul Dominic B Olinares, Hery W Lee, James Chen, Todd C Appleby, Joy Y Feng, John P Bilello, Honkit Ng, Johanna Sotiris, Mark Ebrahim, Eugene Y D Chua, Joshua H Mendez, Edward T Eng, Robert Landick, Matthias Götte, Brian T Chait, Elizabeth A Campbell, Seth A Darst
Structural basis for substrate selection by the SARS-CoV-2 replicase. Nature (2023)
Brandon F Malone, Jason K Perry, Paul Dominic B Olinares, Hery W Lee, James Chen, Todd C Appleby, Joy Y Feng, John P Bilello, Honkit Ng, Johanna Sotiris, Mark Ebrahim, Eugene Y D Chua, Joshua H Mendez, Edward T Eng, Robert Landick, Matthias Götte, Brian T Chait, Elizabeth A Campbell, Seth A Darst
Structural basis for substrate selection by the SARS-CoV-2 replicase. Nature (2023)
Brandon F Malone, Jason K Perry, Paul Dominic B Olinares, Hery W Lee, James Chen, Todd C Appleby, Joy Y Feng, John P Bilello, Honkit Ng, Johanna Sotiris, Mark Ebrahim, Eugene Y D Chua, Joshua H Mendez, Edward T Eng, Robert Landick, Matthias Götte, Brian T Chait, Elizabeth A Campbell, Seth A Darst
Structural basis for substrate selection by the SARS-CoV-2 replicase. Nature (2023)
Brandon F Malone, Jason K Perry, Paul Dominic B Olinares, Hery W Lee, James Chen, Todd C Appleby, Joy Y Feng, John P Bilello, Honkit Ng, Johanna Sotiris, Mark Ebrahim, Eugene Y D Chua, Joshua H Mendez, Edward T Eng, Robert Landick, Matthias Götte, Brian T Chait, Elizabeth A Campbell, Seth A Darst
Structural basis for substrate selection by the SARS-CoV-2 replicase. Nature (2023)
Brandon F Malone, Jason K Perry, Paul Dominic B Olinares, Hery W Lee, James Chen, Todd C Appleby, Joy Y Feng, John P Bilello, Honkit Ng, Johanna Sotiris, Mark Ebrahim, Eugene Y D Chua, Joshua H Mendez, Edward T Eng, Robert Landick, Matthias Götte, Brian T Chait, Elizabeth A Campbell, Seth A Darst
Structural basis for substrate selection by the SARS-CoV-2 replicase. Nature 614 (7949) (2023)
Jin Young Kang, Tatiana V Mishanina, Yu Bao, James Chen, Eliza Llewellyn, James Liu, Seth A Darst, Robert Landick
An ensemble of interconverting conformations of the elemental paused transcription complex creates regulatory options. Proceedings of the National Academy of Sciences of the United States of America 120 (8) (2023)
Jin Young Kang, Tatiana V Mishanina, Yu Bao, James Chen, Eliza Llewellyn, James Liu, Seth A Darst, Robert Landick
An ensemble of interconverting conformations of the elemental paused transcription complex creates regulatory options. Proceedings of the National Academy of Sciences of the United States of America 120 (8) (2023)
Brandon F Malone, Jason K Perry, Paul Dominic B Olinares, Hery W Lee, James Chen, Todd C Appleby, Joy Y Feng, John P Bilello, Honkit Ng, Johanna Sotiris, Mark Ebrahim, Eugene Y D Chua, Joshua H Mendez, Edward T Eng, Robert Landick, Matthias Götte, Brian T Chait, Elizabeth A Campbell, Seth A Darst
Structural basis for substrate selection by the SARS-CoV-2 replicase. Nature (2023)
Brandon F Malone, Jason K Perry, Paul Dominic B Olinares, Hery W Lee, James Chen, Todd C Appleby, Joy Y Feng, John P Bilello, Honkit Ng, Johanna Sotiris, Mark Ebrahim, Eugene Y D Chua, Joshua H Mendez, Edward T Eng, Robert Landick, Matthias Götte, Brian T Chait, Elizabeth A Campbell, Seth A Darst
Structural basis for substrate selection by the SARS-CoV-2 replicase. Nature (2023)
Brandon F Malone, Jason K Perry, Paul Dominic B Olinares, Hery W Lee, James Chen, Todd C Appleby, Joy Y Feng, John P Bilello, Honkit Ng, Johanna Sotiris, Mark Ebrahim, Eugene Y D Chua, Joshua H Mendez, Edward T Eng, Robert Landick, Matthias Götte, Brian T Chait, Elizabeth A Campbell, Seth A Darst
Structural basis for substrate selection by the SARS-CoV-2 replicase. Nature (2023)
Brandon F Malone, Jason K Perry, Paul Dominic B Olinares, Hery W Lee, James Chen, Todd C Appleby, Joy Y Feng, John P Bilello, Honkit Ng, Johanna Sotiris, Mark Ebrahim, Eugene Y D Chua, Joshua H Mendez, Edward T Eng, Robert Landick, Matthias Götte, Brian T Chait, Elizabeth A Campbell, Seth A Darst
Structural basis for substrate selection by the SARS-CoV-2 replicase. Nature (2023)
Jin Young Kang, Tatiana V Mishanina, Yu Bao, James Chen, Eliza Llewellyn, James Liu, Seth A Darst, Robert Landick
An ensemble of interconverting conformations of the elemental paused transcription complex creates regulatory options. Proceedings of the National Academy of Sciences of the United States of America 120 (8) (2023)
Jin Young Kang, Tatiana V Mishanina, Yu Bao, James Chen, Eliza Llewellyn, James Liu, Seth A Darst, Robert Landick
An ensemble of interconverting conformations of the elemental paused transcription complex creates regulatory options. Proceedings of the National Academy of Sciences of the United States of America 120 (8) (2023)
Brandon F Malone, Jason K Perry, Paul Dominic B Olinares, Hery W Lee, James Chen, Todd C Appleby, Joy Y Feng, John P Bilello, Honkit Ng, Johanna Sotiris, Mark Ebrahim, Eugene Y D Chua, Joshua H Mendez, Edward T Eng, Robert Landick, Matthias Götte, Brian T Chait, Elizabeth A Campbell, Seth A Darst
Structural basis for substrate selection by the SARS-CoV-2 replicase. Nature (2023)
James Chen, Qi Wang, Brandon F Malone, Eliza Llewellyn, Yakov Pechersky, Kashyap Maruthi, Edward T Eng, Jason K Perry, Elizabeth A Campbell, David E Shaw, Seth A Darst
Ensemble cryo-EM reveals conformational states of the nsp13 helicase in the SARS-CoV-2 helicase replication-transcription complex. Nature structural & molecular biology 29 (3) (2022)
Porter M Hall, James T Inman, Robert M Fulbright, Tung T Le, Joshua J Brewer, Guillaume Lambert, Seth A Darst, Michelle D Wang
Polarity of the CRISPR roadblock to transcription. Nature structural & molecular biology (2022)
Brandon F Malone, James Chen, Qi Wang, Eliza Llewellyn, Young Joo Choi, Paul Dominic B Olinares, Xinyun Cao, Carolina Hernandez, Edward T Eng, Brian T Chait, David E Shaw, Robert Landick, Seth A Darst, Elizabeth A Campbell
Structural basis for backtracking by the SARS-CoV-2 replication-transcription complex. Proceedings of the National Academy of Sciences of the United States of America 118 (19) (2021)
Wei Dai, Seth A Darst, Christine M Dunham, Robert Landick, Gregory A Petsko, Albert Weixlbaumer
Seeing gene expression in cells: the future of structural biology. Faculty reviews 10 (2021)
Ruth M Saecker, James Chen, Courtney E Chiu, Brandon F Malone, Johanna Sotiris, Mark Ebrahim, Laura Y Yen, Edward T Eng, Seth A Darst
Structural origins of Escherichia coli RNA polymerase open promoter complex stability. Proceedings of the National Academy of Sciences of the United States of America 118 (40) (2021)
Jin Young Kang, Eliza Llewellyn, James Chen, Paul Dominic B Olinares, Joshua Brewer, Brian T Chait, Elizabeth A Campbell, Seth A Darst
Structural basis for transcription complex disruption by the Mfd translocase. eLife 10 (2021)
Venkata P Dandey, William C Budell, Hui Wei, Daija Bobe, Kashyap Maruthi, Mykhailo Kopylov, Edward T Eng, Peter A Kahn, Jenny E Hinshaw, Nidhi Kundu, Crina M Nimigean, Chen Fan, Nattakan Sukomon, Seth A Darst, Ruth M Saecker, James Chen, Brandon Malone, Clinton S Potter, Bridget Carragher
Time-resolved cryo-EM using Spotiton. Nature methods 17 (9) (2020)
Mirjana Lilic, James Chen, Hande Boyaci, Nathaniel R Braffman, Elizabeth A Hubin, Jennifer Herrmann, Daniel Krug, Rachel Mooney, Robert Landick, Seth A Darst, Elizabeth A Campbell
The antibiotic sorangicin A inhibits promoter DNA unwinding in a Mycobacterium tuberculosis rifampicin-resistant RNA polymerase. Proceedings of the National Academy of Sciences of the United States of America 117 (48) (2020)
Nathaniel R Braffman, Frank J Piscotta, Jesse Hauver, Elizabeth A Campbell, A James Link, Seth A Darst
Structural mechanism of transcription inhibition by lasso peptides microcin J25 and capistruin. Proceedings of the National Academy of Sciences of the United States of America 116 (4) (2019)
Alexis Jaramillo Cartagena, Amy B Banta, Nikhil Sathyan, Wilma Ross, Richard L Gourse, Elizabeth A Campbell, Seth A Darst
Structural basis for transcription activation by Crl through tethering of σS and RNA polymerase. Proceedings of the National Academy of Sciences of the United States of America 116 (38) (2019)
James Chen, Saumya Gopalkrishnan, Courtney Chiu, Albert Y Chen, Elizabeth A Campbell, Richard L Gourse, Wilma Ross, Seth A Darst
E. coli TraR allosterically regulates transcription initiation by altering RNA polymerase conformation. eLife 8 (2019)
Andrey Feklistov, Brian Bae, Jesse Hauver, Agnieszka Lass-Napiorkowska, Markus Kalesse, Florian Glaus, Karl-Heinz Altmann, Tomasz Heyduk, Robert Landick, Seth A Darst
RNA polymerase motions during promoter melting. Science (New York, N.Y.) 356 (6340) (2018)
Hande Boyaci, James Chen, Mirjana Lilic, Margaret Palka, Rachel Anne Mooney, Robert Landick, Seth A Darst, Elizabeth A Campbell
Fidaxomicin jams Mycobacterium tuberculosis RNA polymerase motions needed for initiation via RbpA contacts. eLife 7 (2018)
Elizabeth A Hubin, Allison Fay, Catherine Xu, James M Bean, Ruth M Saecker, Michael S Glickman, Seth A Darst, Elizabeth A Campbell
Structure and function of the mycobacterial transcription initiation complex with the essential regulator RbpA. eLife 6 (2017)
Jin Young Kang, Paul Dominic B Olinares, James Chen, Elizabeth A Campbell, Arkady Mustaev, Brian T Chait, Max E Gottesman, Seth A Darst
Structural basis of transcription arrest by coliphage HK022 Nun in an Escherichia coli RNA polymerase elongation complex. eLife 6 (2017)
Elizabeth A Campbell, Shreya Kamath, Kanagalaghatta R Rajashankar, Mengyu Wu, Seth A Darst
Crystal structure of Aquifex aeolicus σN bound to promoter DNA and the structure of σN-holoenzyme. Proceedings of the National Academy of Sciences of the United States of America 114 (10) (2017)