Soren Riis Paludan (S R Paludan, Soren R Paludan, Søren R Paludan, Søren Riis Paludan, Trine H Mogensen)

Loop profile ORCID

Publication Activity (10 Years)

Years Active: 2015-2024
Publications (10 Years): 62

Top Venues

Nature

Journal of clinical immunology

The EMBO journal

Nature communications

Aarhus Universitet

Aarhus Universitet (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

Aarhus Universitet May 01 2010

Denmark

Professor :: Biomedicine

Education History

Aarhus Universitet Aug 01 1996 - Jul 31 2000

Denmark

PHD :: Microbiology and Immunology

Publications

Michelle Mølgaard Thomsen, Morten Kelder Skouboe, Michelle Møhlenberg, Jian Zhao, Kerstin de Keukeleere, Johanna Laura Heinz, Marvin Werner, Anne Kruse Hollensen, Jonas Lønskov, Ian Nielsen, Madalina Elena Carter-Timofte, Baocun Zhang, Jacob Giehm Mikkelsen, Niels Fisker, Søren R Paludan, Kristian Assing, Soren Riis Paludan
Impaired STING Activation Due to a Variant in the E3 Ubiquitin Ligase AMFR in a Patient with Severe VZV Infection and Hemophagocytic Lymphohistiocytosis. Journal of clinical immunology 44 (2) (2024)
Michelle Mølgaard Thomsen, Morten Kelder Skouboe, Michelle Møhlenberg, Jian Zhao, Kerstin de Keukeleere, Johanna Laura Heinz, Marvin Werner, Anne Kruse Hollensen, Jonas Lønskov, Ian Nielsen, Madalina Elena Carter-Timofte, Baocun Zhang, Jacob Giehm Mikkelsen, Niels Fisker, Søren R Paludan, Kristian Assing, Soren Riis Paludan
Impaired STING Activation Due to a Variant in the E3 Ubiquitin Ligase AMFR in a Patient with Severe VZV Infection and Hemophagocytic Lymphohistiocytosis. Journal of clinical immunology 44 (2) (2024)
Michelle Mølgaard Thomsen, Morten Kelder Skouboe, Michelle Møhlenberg, Jian Zhao, Kerstin de Keukeleere, Johanna Laura Heinz, Marvin Werner, Anne Kruse Hollensen, Jonas Lønskov, Ian Nielsen, Madalina Elena Carter-Timofte, Baocun Zhang, Jacob Giehm Mikkelsen, Niels Fisker, Søren R Paludan, Kristian Assing, Soren Riis Paludan
Impaired STING Activation Due to a Variant in the E3 Ubiquitin Ligase AMFR in a Patient with Severe VZV Infection and Hemophagocytic Lymphohistiocytosis. Journal of clinical immunology 44 (2) (2024)
Yi-Hao Chan, Zhiyong Liu, Paul Bastard, Noopur Khobrekar, Kennen M Hutchison, Yasuhiro Yamazaki, Qing Fan, Daniela Matuozzo, Oliver Harschnitz, Nacim Kerrouche, Koji Nakajima, Param Amin, Ahmad Yatim, Darawan Rinchai, Jie Chen, Peng Zhang, Gabriele Ciceri, Jia Chen, A Kerry Dobbs, Serkan Belkaya, Danyel Lee, Adrian Gervais, Kürşad Aydın, Ayse Kartal, Mary L Hasek, Shuxiang Zhao, Eduardo Garcia Reino, Yoon Seung Lee, Yoann Seeleuthner, Matthieu Chaldebas, Rasheed Bailey, Catherine Vanhulle, Lazaro Lorenzo, Soraya Boucherit, Flore Rozenberg, Nico Marr, Trine Hyrup Mogensen, Mélodie Aubart, Aurélie Cobat, Olivier Dulac, Melike Emiroğlu, Soren Riis Paludan, Laurent Abel, Luigi Daniele Notarangelo, Richard Longnecker, Gregory A Smith, Lorenz Studer, Jean-Laurent Casanova, Shen-Ying Zhang
Human TMEFF1 is a restriction factor for herpes simplex virus in the brain. Nature 632 (8024) (2024)
Yi-Hao Chan, Zhiyong Liu, Paul Bastard, Noopur Khobrekar, Kennen M Hutchison, Yasuhiro Yamazaki, Qing Fan, Daniela Matuozzo, Oliver Harschnitz, Nacim Kerrouche, Koji Nakajima, Param Amin, Ahmad Yatim, Darawan Rinchai, Jie Chen, Peng Zhang, Gabriele Ciceri, Jia Chen, A Kerry Dobbs, Serkan Belkaya, Danyel Lee, Adrian Gervais, Kürşad Aydın, Ayse Kartal, Mary L Hasek, Shuxiang Zhao, Eduardo Garcia Reino, Yoon Seung Lee, Yoann Seeleuthner, Matthieu Chaldebas, Rasheed Bailey, Catherine Vanhulle, Lazaro Lorenzo, Soraya Boucherit, Flore Rozenberg, Nico Marr, Trine Hyrup Mogensen, Mélodie Aubart, Aurélie Cobat, Olivier Dulac, Melike Emiroğlu, Soren Riis Paludan, Laurent Abel, Luigi Daniele Notarangelo, Richard Longnecker, Gregory A Smith, Lorenz Studer, Jean-Laurent Casanova, Shen-Ying Zhang
Human TMEFF1 is a restriction factor for herpes simplex virus in the brain. Nature 632 (8024) (2024)
Michelle Mølgaard Thomsen, Morten Kelder Skouboe, Michelle Møhlenberg, Jian Zhao, Kerstin de Keukeleere, Johanna Laura Heinz, Marvin Werner, Anne Kruse Hollensen, Jonas Lønskov, Ian Nielsen, Madalina Elena Carter-Timofte, Baocun Zhang, Jacob Giehm Mikkelsen, Niels Fisker, Søren R Paludan, Kristian Assing, Soren Riis Paludan
Impaired STING Activation Due to a Variant in the E3 Ubiquitin Ligase AMFR in a Patient with Severe VZV Infection and Hemophagocytic Lymphohistiocytosis. Journal of clinical immunology 44 (2) (2024)
Bao-Cun Zhang, Marlene Fyrstenberg Laursen, Lili Hu, Hossein Hazrati, Ryo Narita, Lea S Jensen, Aida S Hansen, Jinrong Huang, Yan Zhang, Xiangning Ding, Maimaitili Muyesier, Emil Nilsson, Agnieszka Banasik, Christina Zeiler, Trine Hyrup Mogensen, Anders Etzerodt, Ralf Agger, Mogens Johannsen, Emil Kofod-Olsen, Soren Riis Paludan, Martin Roelsgaard Jakobsen
Cholesterol-binding motifs in STING that control endoplasmic reticulum retention mediate anti-tumoral activity of cholesterol-lowering compounds. Nature communications 15 (1) (2024)
Anna Macht, Yiqi Huang, Line S Reinert, Vincent Grass, Kristin Lohmer, Elke Tatjana Aristizabal Prada, Eveline Babel, Alexandra Semmler, Wen Zhang, Andrea Wegner, Eva Lichtenegger-Hartl, Sonja Haas, Günther Hasenpusch, Steffen Meyer, Soren Riis Paludan, Andreas Pichlmair, Carsten Rudolph, Thomas Langenickel
Mucosal IFNλ1 mRNA-based immunomodulation effectively reduces SARS-CoV-2 induced mortality in mice. EMBO reports (2024)
Yao Dai, Manja Idorn, Manutea C Serrero, Xiaoyong Pan, Emil Aagaard Thomsen, Ryo Narita, Muyesier Maimaitili, Xiaoqing Qian, Marie B Iversen, Line S Reinert, Rasmus K Flygaard, Muwan Chen, Xiangning Ding, Bao-Cun Zhang, Madalina E Carter-Timofte, Qing Lu, Zhuofan Jiang, Yiye Zhong, Shuhui Zhang, Lintai Da, Jinwei Zhu, Mark Denham, Poul Nissen, Trine Hyrup Mogensen, Jacob Giehm Mikkelsen, Shen-Ying Zhang, Jean-Laurent Casanova, Yujia Cai, Soren Riis Paludan
TMEFF1 is a neuron-specific restriction factor for herpes simplex virus. Nature 632 (8024) (2024)
Yi-Hao Chan, Zhiyong Liu, Paul Bastard, Noopur Khobrekar, Kennen M Hutchison, Yasuhiro Yamazaki, Qing Fan, Daniela Matuozzo, Oliver Harschnitz, Nacim Kerrouche, Koji Nakajima, Param Amin, Ahmad Yatim, Darawan Rinchai, Jie Chen, Peng Zhang, Gabriele Ciceri, Jia Chen, A Kerry Dobbs, Serkan Belkaya, Danyel Lee, Adrian Gervais, Kürşad Aydın, Ayse Kartal, Mary L Hasek, Shuxiang Zhao, Eduardo Garcia Reino, Yoon Seung Lee, Yoann Seeleuthner, Matthieu Chaldebas, Rasheed Bailey, Catherine Vanhulle, Lazaro Lorenzo, Soraya Boucherit, Flore Rozenberg, Nico Marr, Trine Hyrup Mogensen, Mélodie Aubart, Aurélie Cobat, Olivier Dulac, Melike Emiroğlu, Soren Riis Paludan, Laurent Abel, Luigi Daniele Notarangelo, Richard Longnecker, Gregory A Smith, Lorenz Studer, Jean-Laurent Casanova, Shen-Ying Zhang
Human TMEFF1 is a restriction factor for herpes simplex virus in the brain. Nature 632 (8024) (2024)
Pichpisith Pierre Vejvisithsakul, Chisanu Thumarat, Asada Leelahavanichkul, Nattiya Hirankan, Trairak Pisitkun, Soren Riis Paludan, Prapaporn Pisitkun
Elucidating the function of STING in systemic lupus erythematosus through the STING Goldenticket mouse mutant. Scientific reports 14 (1) (2024)
Yao Dai, Manja Idorn, Manutea C Serrero, Xiaoyong Pan, Emil Aagaard Thomsen, Ryo Narita, Muyesier Maimaitili, Xiaoqing Qian, Marie B Iversen, Line S Reinert, Rasmus K Flygaard, Muwan Chen, Xiangning Ding, Bao-Cun Zhang, Madalina E Carter-Timofte, Qing Lu, Zhuofan Jiang, Yiye Zhong, Shuhui Zhang, Lintai Da, Jinwei Zhu, Mark Denham, Poul Nissen, Trine Hyrup Mogensen, Jacob Giehm Mikkelsen, Shen-Ying Zhang, Jean-Laurent Casanova, Yujia Cai, Soren Riis Paludan
TMEFF1 is a neuron-specific restriction factor for herpes simplex virus. Nature 632 (8024) (2024)
Bao-Cun Zhang, Marlene Fyrstenberg Laursen, Lili Hu, Hossein Hazrati, Ryo Narita, Lea S Jensen, Aida S Hansen, Jinrong Huang, Yan Zhang, Xiangning Ding, Maimaitili Muyesier, Emil Nilsson, Agnieszka Banasik, Christina Zeiler, Trine Hyrup Mogensen, Anders Etzerodt, Ralf Agger, Mogens Johannsen, Emil Kofod-Olsen, Soren Riis Paludan, Martin Roelsgaard Jakobsen
Cholesterol-binding motifs in STING that control endoplasmic reticulum retention mediate anti-tumoral activity of cholesterol-lowering compounds. Nature communications 15 (1) (2024)
Demi van der Horst, Naziia Kurmasheva, Mikkel H S Marqvorsen, Sonia Assil, Anna Halling Folkmar Andersen, Christoph F Kollmann, Leandro Silva da Costa, Qi Wu, Jian Zhao, Eleonora Cesari, Marie B Iversen, Fanghui Ren, Trine I Jensen, Ryo Narita, Vivien R Schack, Bao-Cun Zhang, Rasmus O Bak, Claudio Sette, Robert A Fenton, Jacob G Mikkelsen, Soren Riis Paludan, David Olagnier
SAM68 directs STING signaling to apoptosis in macrophages. Communications biology 7 (1) (2024)
Yi-Hao Chan, Zhiyong Liu, Paul Bastard, Noopur Khobrekar, Kennen M Hutchison, Yasuhiro Yamazaki, Qing Fan, Daniela Matuozzo, Oliver Harschnitz, Nacim Kerrouche, Koji Nakajima, Param Amin, Ahmad Yatim, Darawan Rinchai, Jie Chen, Peng Zhang, Gabriele Ciceri, Jia Chen, A Kerry Dobbs, Serkan Belkaya, Danyel Lee, Adrian Gervais, Kürşad Aydın, Ayse Kartal, Mary L Hasek, Shuxiang Zhao, Eduardo Garcia Reino, Yoon Seung Lee, Yoann Seeleuthner, Matthieu Chaldebas, Rasheed Bailey, Catherine Vanhulle, Lazaro Lorenzo, Soraya Boucherit, Flore Rozenberg, Nico Marr, Trine Hyrup Mogensen, Mélodie Aubart, Aurélie Cobat, Olivier Dulac, Melike Emiroğlu, Soren Riis Paludan, Laurent Abel, Luigi Daniele Notarangelo, Richard Longnecker, Gregory A Smith, Lorenz Studer, Jean-Laurent Casanova, Shen-Ying Zhang
Human TMEFF1 is a restriction factor for herpes simplex virus in the brain. Nature (2024)
Anna Macht, Yiqi Huang, Line S Reinert, Vincent Grass, Kristin Lohmer, Elke Tatjana Aristizabal Prada, Eveline Babel, Alexandra Semmler, Wen Zhang, Andrea Wegner, Eva Lichtenegger-Hartl, Sonja Haas, Günther Hasenpusch, Steffen Meyer, Soren Riis Paludan, Andreas Pichlmair, Carsten Rudolph, Thomas Langenickel
Mucosal IFNλ1 mRNA-based immunomodulation effectively reduces SARS-CoV-2 induced mortality in mice. EMBO reports (2024)
Pichpisith Pierre Vejvisithsakul, Chisanu Thumarat, Asada Leelahavanichkul, Nattiya Hirankan, Trairak Pisitkun, Soren Riis Paludan, Prapaporn Pisitkun
Elucidating the function of STING in systemic lupus erythematosus through the STING Goldenticket mouse mutant. Scientific reports 14 (1) (2024)
Michelle Mølgaard Thomsen, Morten Kelder Skouboe, Michelle Møhlenberg, Jian Zhao, Kerstin de Keukeleere, Johanna Laura Heinz, Marvin Werner, Anne Kruse Hollensen, Jonas Lønskov, Ian Nielsen, Madalina Elena Carter-Timofte, Baocun Zhang, Jacob Giehm Mikkelsen, Niels Fisker, Søren R Paludan, Kristian Assing, Soren Riis Paludan
Impaired STING Activation Due to a Variant in the E3 Ubiquitin Ligase AMFR in a Patient with Severe VZV Infection and Hemophagocytic Lymphohistiocytosis. Journal of clinical immunology 44 (2) (2024)
Yao Dai, Manja Idorn, Manutea C Serrero, Xiaoyong Pan, Emil Aagaard Thomsen, Ryo Narita, Muyesier Maimaitili, Xiaoqing Qian, Marie B Iversen, Line S Reinert, Rasmus K Flygaard, Muwan Chen, Xiangning Ding, Bao-Cun Zhang, Madalina E Carter-Timofte, Qing Lu, Zhuofan Jiang, Yiye Zhong, Shuhui Zhang, Lintai Da, Jinwei Zhu, Mark Denham, Poul Nissen, Trine Hyrup Mogensen, Jacob Giehm Mikkelsen, Shen-Ying Zhang, Jean-Laurent Casanova, Yujia Cai, Soren Riis Paludan
TMEFF1 is a neuron-specific restriction factor for herpes simplex virus. Nature (2024)
Demi van der Horst, Naziia Kurmasheva, Mikkel H S Marqvorsen, Sonia Assil, Anna Halling Folkmar Andersen, Christoph F Kollmann, Leandro Silva da Costa, Qi Wu, Jian Zhao, Eleonora Cesari, Marie B Iversen, Fanghui Ren, Trine I Jensen, Ryo Narita, Vivien R Schack, Bao-Cun Zhang, Rasmus O Bak, Claudio Sette, Robert A Fenton, Jacob G Mikkelsen, Soren Riis Paludan, David Olagnier
SAM68 directs STING signaling to apoptosis in macrophages. Communications biology 7 (1) (2024)
Michelle Mølgaard Thomsen, Morten Kelder Skouboe, Michelle Møhlenberg, Jian Zhao, Kerstin de Keukeleere, Johanna Laura Heinz, Marvin Werner, Anne Kruse Hollensen, Jonas Lønskov, Ian Nielsen, Madalina Elena Carter-Timofte, Baocun Zhang, Jacob Giehm Mikkelsen, Niels Fisker, Søren R Paludan, Kristian Assing, Soren Riis Paludan
Impaired STING Activation Due to a Variant in the E3 Ubiquitin Ligase AMFR in a Patient with Severe VZV Infection and Hemophagocytic Lymphohistiocytosis. Journal of clinical immunology 44 (2) (2024)
Demi van der Horst, Naziia Kurmasheva, Mikkel H S Marqvorsen, Sonia Assil, Anna Halling Folkmar Andersen, Christoph F Kollmann, Leandro Silva da Costa, Qi Wu, Jian Zhao, Eleonora Cesari, Marie B Iversen, Fanghui Ren, Trine I Jensen, Ryo Narita, Vivien R Schack, Bao-Cun Zhang, Rasmus O Bak, Claudio Sette, Robert A Fenton, Jacob G Mikkelsen, Soren Riis Paludan, David Olagnier
SAM68 directs STING signaling to apoptosis in macrophages. Communications biology 7 (1) (2024)
Pichpisith Pierre Vejvisithsakul, Chisanu Thumarat, Asada Leelahavanichkul, Nattiya Hirankan, Trairak Pisitkun, Soren Riis Paludan, Prapaporn Pisitkun
Elucidating the function of STING in systemic lupus erythematosus through the STING Goldenticket mouse mutant. Scientific reports 14 (1) (2024)
Michelle Mølgaard Thomsen, Morten Kelder Skouboe, Michelle Møhlenberg, Jian Zhao, Kerstin de Keukeleere, Johanna Laura Heinz, Marvin Werner, Anne Kruse Hollensen, Jonas Lønskov, Ian Nielsen, Madalina Elena Carter-Timofte, Baocun Zhang, Jacob Giehm Mikkelsen, Niels Fisker, Søren R Paludan, Kristian Assing, Soren Riis Paludan
Impaired STING Activation Due to a Variant in the E3 Ubiquitin Ligase AMFR in a Patient with Severe VZV Infection and Hemophagocytic Lymphohistiocytosis. Journal of clinical immunology 44 (2) (2024)
Bao-Cun Zhang, Marlene Fyrstenberg Laursen, Lili Hu, Hossein Hazrati, Ryo Narita, Lea S Jensen, Aida S Hansen, Jinrong Huang, Yan Zhang, Xiangning Ding, Maimaitili Muyesier, Emil Nilsson, Agnieszka Banasik, Christina Zeiler, Trine Hyrup Mogensen, Anders Etzerodt, Ralf Agger, Mogens Johannsen, Emil Kofod-Olsen, Soren Riis Paludan, Martin Roelsgaard Jakobsen
Cholesterol-binding motifs in STING that control endoplasmic reticulum retention mediate anti-tumoral activity of cholesterol-lowering compounds. Nature communications 15 (1) (2024)
Demi van der Horst, Naziia Kurmasheva, Mikkel H S Marqvorsen, Sonia Assil, Anna Halling Folkmar Andersen, Christoph F Kollmann, Leandro Silva da Costa, Qi Wu, Jian Zhao, Eleonora Cesari, Marie B Iversen, Fanghui Ren, Trine I Jensen, Ryo Narita, Vivien R Schack, Bao-Cun Zhang, Rasmus O Bak, Claudio Sette, Robert A Fenton, Jacob G Mikkelsen, Soren Riis Paludan, David Olagnier
SAM68 directs STING signaling to apoptosis in macrophages. Communications biology 7 (1) (2024)
Yi-Hao Chan, Zhiyong Liu, Paul Bastard, Noopur Khobrekar, Kennen M Hutchison, Yasuhiro Yamazaki, Qing Fan, Daniela Matuozzo, Oliver Harschnitz, Nacim Kerrouche, Koji Nakajima, Param Amin, Ahmad Yatim, Darawan Rinchai, Jie Chen, Peng Zhang, Gabriele Ciceri, Jia Chen, A Kerry Dobbs, Serkan Belkaya, Danyel Lee, Adrian Gervais, Kürşad Aydın, Ayse Kartal, Mary L Hasek, Shuxiang Zhao, Eduardo Garcia Reino, Yoon Seung Lee, Yoann Seeleuthner, Matthieu Chaldebas, Rasheed Bailey, Catherine Vanhulle, Lazaro Lorenzo, Soraya Boucherit, Flore Rozenberg, Nico Marr, Trine Hyrup Mogensen, Mélodie Aubart, Aurélie Cobat, Olivier Dulac, Melike Emiroğlu, Soren Riis Paludan, Laurent Abel, Luigi Daniele Notarangelo, Richard Longnecker, Gregory A Smith, Lorenz Studer, Jean-Laurent Casanova, Shen-Ying Zhang
Human TMEFF1 is a restriction factor for herpes simplex virus in the brain. Nature 632 (8024) (2024)
Yi-Hao Chan, Zhiyong Liu, Paul Bastard, Noopur Khobrekar, Kennen M Hutchison, Yasuhiro Yamazaki, Qing Fan, Daniela Matuozzo, Oliver Harschnitz, Nacim Kerrouche, Koji Nakajima, Param Amin, Ahmad Yatim, Darawan Rinchai, Jie Chen, Peng Zhang, Gabriele Ciceri, Jia Chen, A Kerry Dobbs, Serkan Belkaya, Danyel Lee, Adrian Gervais, Kürşad Aydın, Ayse Kartal, Mary L Hasek, Shuxiang Zhao, Eduardo Garcia Reino, Yoon Seung Lee, Yoann Seeleuthner, Matthieu Chaldebas, Rasheed Bailey, Catherine Vanhulle, Lazaro Lorenzo, Soraya Boucherit, Flore Rozenberg, Nico Marr, Trine Hyrup Mogensen, Mélodie Aubart, Aurélie Cobat, Olivier Dulac, Melike Emiroğlu, Soren Riis Paludan, Laurent Abel, Luigi Daniele Notarangelo, Richard Longnecker, Gregory A Smith, Lorenz Studer, Jean-Laurent Casanova, Shen-Ying Zhang
Human TMEFF1 is a restriction factor for herpes simplex virus in the brain. Nature 632 (8024) (2024)
Line Lykke Andersen, Yiqi Huang, Christian Urban, Lila Oubraham, Elena Winheim, Che Stafford, Dennis Nagl, Fionan O'Duill, Thomas Ebert, Thomas Engleitner, Soren Riis Paludan, Anne B Krug, Roland Rad, Veit Hornung, Andreas Pichlmair
Systematic P2Y receptor survey identifies P2Y11 as modulator of immune responses and virus replication in macrophages. The EMBO journal (2023)
Fanghui Ren, Ryo Narita, Ahmad S Rashidi, Stefanie Fruhwürth, Zongliang Gao, Rasmus O Bak, Martin K Thomsen, Georges G M G M Verjans, Line S Reinert, Soren Riis Paludan
ER stress induces caspase-2-tBID-GSDME-dependent cell death in neurons lytically infected with herpes simplex virus type 2. The EMBO journal (2023)
Giorgia Marino, Baocun Zhang, Alexander Schmitz, Hanna Vf Schwensen, Line S Reinert, Soren Riis Paludan
STING is redundant for host defense and pathology of COVID-19-like disease in mice. Life science alliance 6 (8) (2023)
Sonia Assil, Soren Riis Paludan
STING is ESCRTed to degradation by microautophagy. Nature cell biology 25 (3) (2023)
Stefanie Fruhwürth, Line S Reinert, Carl Öberg, Marcelina Sakr, Marcus Stahlman, Henrik Zetterberg, Soren Riis Paludan
TREM2 is down-regulated by HSV1 in microglia and involved in antiviral defense in the brain. Science advances 9 (33) (2023)
Sonia Assil, Soren Riis Paludan
STING is ESCRTed to degradation by microautophagy. Nature cell biology 25 (3) (2023)
Kristian Assing, Sofie E Jørgensen, Katrine S Sandgaard, Kerstin De Keukeleere, Marie B-Hansen, Mikkel S Petersen, Ulla B Hartling, Thanis M K-de Vaal, Christian Nielsen, Marianne A Jakobsen, Eleanor Watt, Stuart Adams, Qin Hao, Christina Fagerberg, Soren Riis Paludan
A Novel CDC42 Variant with Impaired Thymopoiesis, IL-7R Signaling, PAK1 Binding, and TCR Repertoire Diversity. Journal of clinical immunology (2023)
Christopher James Arthur Duncan, Morten Kelder Skouboe, Sophie Howarth, Anne Kruse Hollensen, Rui Chen, Malene Landbo Børresen, Benjamin J Thompson, Jarmila Stremenova Spegarova, Catherine F Hatton, Frederik Filip Stæger, Mette K Andersen, John Whittaker, Soren Riis Paludan, Sofie Eg Jørgensen, Martin K Thomsen, Jacob Giehm Mikkelsen, Carsten Heilmann, Daniela Buhas, Nina F Øbro, Jakob Thaning Bay, Hanne Vibeke Hansen Marquart, M Teresa de la Morena, Joseph A Klejka, Matthew Hirschfeld, Line Gutte Borgwardt, Isabel Forss, Tania Nicole Masmas, Anja Poulsen, Francisco Noya, Guy A Rouleau, Torben Hansen, Sirui Zhou, Anders Albrechtsen, Reza Alizadehfar, Eric J Allenspach, Sophie Hambleton, Trine Hyrup Mogensen
Life-threatening viral disease in a novel form of autosomal recessive IFNAR2 deficiency in the Arctic. The Journal of experimental medicine 219 (6) (2022)
Georgios Katzilieris-Petras, Xin Lai, Ahmad S Rashidi, Georges M G M Verjans, Line S Reinert, Soren Riis Paludan
Microglia Activate Early Antiviral Responses upon Herpes Simplex Virus 1 Entry into the Brain to Counteract Development of Encephalitis-Like Disease in Mice. Journal of virology 96 (6) (2022)
Ruoshi Peng, Chris Kedong Wang, Xuan Wang-Kan, Manja Idorn, Majken Kjaer, Felix Yuran Zhou, Berthe Katrine Fiil, Frederik Timmermann, Susana L Orozco, Julia McCarthy, Carol S Leung, Xin Lu, Katrin Bagola, Jan Rehwinkel, Andrew Oberst, Jonathan Maelfait, Soren Riis Paludan, Mads Gyrd-Hansen
Human ZBP1 induces cell death-independent inflammatory signaling via RIPK3 and RIPK1. EMBO reports 23 (12) (2022)
Soren Riis Paludan, Trine Hyrup Mogensen
Innate immunological pathways in COVID-19 pathogenesis. Science immunology 7 (67) (2022)
Renée M van der Sluis, Lamin B Cham, Albert Gris-Oliver, Kristine R Gammelgaard, Jesper G Pedersen, Manja Idorn, Ulvi Ahmadov, Sabina Sanches Hernandez, Ena Cémalovic, Stine H Godsk, Jacob Thyrsted, Jesper Damsgaard Gunst, Silke D Nielsen, Janni J Jørgensen, Tobias Wang Bjerg, Anders Laustsen, Line S Reinert, David Olagnier, Rasmus O Bak, Mads Kjolby, Christian Kanstrup Holm, Martin Tolstrup, Soren Riis Paludan, Lasse S Kristensen, Ole Schmeltz Søgaard, Martin Roelsgaard Jakobsen
TLR2 and TLR7 mediate distinct immunopathological and antiviral plasmacytoid dendritic cell responses to SARS-CoV-2 infection. The EMBO journal 41 (10) (2022)
Cyrielle Fougeroux, Louise Goksøyr, Manja Idorn, Vladislav Soroka, Sebenzile K Myeni, Robert Dagil, Christoph M Janitzek, Max Søgaard, Kara-Lee Aves, Emma W Horsted, Sayit Mahmut Erdoğan, Tobias Gustavsson, Jerzy Dorosz, Stine Clemmensen, Laurits Fredsgaard, Susan Thrane, Elena Ethel Vidal-Calvo, Paul Khalifé, Thomas M Hulen, Swati Choudhary, Michael Theisen, Susheel K Singh, Asier Garcia-Senosiain, Linda Van Oosten, Gorben P Pijlman, Bettina Hierzberger, Tanja Domeyer, Blanka W Nalewajek, Anette Strøbæk, Magdalena Skrzypczak, Laura F Andersson, Soren Buus, Anette Stryhn Buus, Jan Pravsgaard Christensen, Tim J Dalebout, Kasper Iversen, Lene H Harritshøj, Benjamin Mordmüller, Henrik Ullum, Line S Reinert, Willem Adriaan de Jongh, Marjolein Kikkert, Soren Riis Paludan, Thor G Theander, Morten Agertoug Nielsen, Ali Salanti, Adam Frederik Sander
Capsid-like particles decorated with the SARS-CoV-2 receptor-binding domain elicit strong virus neutralization activity. Nature communications 12 (1) (2021)
Di Yin, Sikai Ling, Da-Wei Wang, Yao Dai, Hao Jiang, Xujiao Zhou, Soren Riis Paludan, Jiaxu Hong, Yujia Cai
Targeting herpes simplex virus with CRISPR-Cas9 cures herpetic stromal keratitis in mice. Nature biotechnology 39 (5) (2021)
Alon Schneider Hait, David Olagnier, Sancho-Shimizu Vanessa, Kristian Alsbjerg Skipper, Marie Helleberg, Simon Muller Larsen, Chiranjeevi Bodda, Liviu Ionut Moldovan, Fanghui Ren, Nanna-Sophie Brinck Andersen, Michelle M Thomsen, Mette Ratzer Freytag, Sathya Darmalinggam, Isobel Parkes, Darshana D Kadekar, Stine Hess Rahbek, Demi van der Horst, Lasse Sommer Kristensen, Kristina Eriksson, Jørgen Kjems, Serge Mostowy, Mette Christiansen, Jacob Giehm Mikkelsen, Christian Thomas Brandt, Soren Riis Paludan, Trine Hyrup Mogensen
Defects in LC3B2 and ATG4A underlie HSV2 meningitis and reveal a critical role for autophagy in antiviral defense in humans. Science immunology 5 (54) (2021)
Sikai Ling, Shiqi Yang, Xinde Hu, Di Yin, Yao Dai, Xiaoqing Qian, Da-Wei Wang, Xiaoyong Pan, Jiaxu Hong, Xiaodong Sun, Hui Yang, Soren Riis Paludan, Yujia Cai
Lentiviral delivery of co-packaged Cas9 mRNA and a Vegfa-targeting guide RNA prevents wet age-related macular degeneration in mice. Nature biomedical engineering 5 (2) (2021)
Maria Riedel, Martin F Berthelsen, Huiqiang Cai, Jakob Haldrup, Michael Borre, Soren Riis Paludan, Henrik Hager, Mikkel H Vendelbo, Erwin F Wagner, Latifa Bakiri, Martin K Thomsen
In vivo CRISPR inactivation of Fos promotes prostate cancer progression by altering the associated AP-1 subunit Jun. Oncogene 40 (13) (2021)
J Guerra, A-L Valadao, Dimitrios Vlachakis, K Polak, Isabelle K Vila, Clara Taffoni, T Prabakaran, A S Marriott, Renata Kaczmarek, A Houel, B Auzemery, Stéphanie Déjardin, Pierre Boudinot, Barbara Nawrot, N J Jones, Soren Riis Paludan, S Kossida, Christelle Langevin, Nadine Laguette
Lysyl-tRNA synthetase produces diadenosine tetraphosphate to curb STING-dependent inflammation. Science advances 6 (21) (2020)
Kristian Juul-Madsen, Per Qvist, Kirstine L Bendtsen, Annette Eva Langkilde, Bente Vestergaard, Kenneth A Howard, Martxel Dehesa-Etxebeste, Soren Riis Paludan, Gregers Rom Andersen, Poul Henning Jensen, Daniel E Otzen, Marina Romero-Ramos, Thomas Vorup-Jensen
Size-Selective Phagocytic Clearance of Fibrillar α-Synuclein through Conformational Activation of Complement Receptor 4. Journal of immunology (Baltimore, Md. : 1950) 204 (5) (2020)
Soren Riis Paludan, Thomas Pradeu, Seth L Masters, Trine H Mogensen
Constitutive immune mechanisms: mediators of host defence and immune regulation. Nature reviews. Immunology 21 (3) (2020)
David Olagnier, Ensieh Farahani, Jacob Thyrsted, Julia Blay-Cadanet, Angela Herengt, Manja Idorn, Alon Hait, Bruno Hernaez, Alice Knudsen, Marie Beck Iversen, Mirjam Schilling, Sofie E Jørgensen, Michelle Thomsen, Line S Reinert, Michael Lappe, Huy-Dung Hoang, Victoria H Gilchrist, Anne Louise Hansen, Rasmus Ottosen, Camilla G Nielsen, Charlotte Møller, Demi van der Horst, Suraj Peri, Siddharth Balachandran, Jinrong Huang, Martin Roelsgaard Jakobsen, Esben B Svenningsen, Thomas B Poulsen, Lydia Bartsch, Anne L Thielke, Yonglun Luo, Tommy Alain, Jan Rehwinkel, Antonio Alcami, John Hiscott, Trine H Mogensen, Soren Riis Paludan, Christian Kanstrup Holm
Author Correction: SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate. Nature communications 11 (1) (2020)
David Olagnier, Ensieh Farahani, Jacob Thyrsted, Julia Blay-Cadanet, Angela Herengt, Manja Idorn, Alon Hait, Bruno Hernaez, Alice Knudsen, Marie Beck Iversen, Mirjam Schilling, Sofie E Jørgensen, Michelle Thomsen, Line S Reinert, Michael Lappe, Huy-Dung Hoang, Victoria H Gilchrist, Anne Louise Hansen, Rasmus Ottosen, Camilla G Nielsen, Charlotte Møller, Demi van der Horst, Suraj Peri, Siddharth Balachandran, Jinrong Huang, Martin Roelsgaard Jakobsen, Esben B Svenningsen, Thomas B Poulsen, Lydia Bartsch, Anne L Thielke, Yonglun Luo, Tommy Alain, Jan Rehwinkel, Antonio Alcami, John Hiscott, Trine H Mogensen, Soren Riis Paludan, Christian Kanstrup Holm
SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate. Nature communications 11 (1) (2020)
Bao-Cun Zhang, Ramya Nandakumar, Line S Reinert, Jinrong Huang, Anders Laustsen, Zong-Liang Gao, Cheng-Long Sun, Søren Beck Jensen, Anne Troldborg, Sonia Assil, Martin F Berthelsen, Carsten Scavenius, Yan Zhang, Samuel J Windross, David Olagnier, Thaneas Prabakaran, Chiranjeevi Bodda, Ryo Narita, Yujia Cai, Cong-Gang Zhang, Harald Alfred Stenmark, Christine M Doucet, Takeshi Noda, Zheng Guo, Raphaela Goldbach-Mansky, Rune Hartmann, Zhijian J Chen, Jan J Enghild, Rasmus O Bak, Martin K Thomsen, Soren Riis Paludan
STEEP mediates STING ER exit and activation of signaling. Nature immunology 21 (8) (2020)
Markus Stempel, Baca Chan, Vanda Juranić Lisnić, Astrid Krmpotić, Josephine Hartung, Soren Riis Paludan, Nadia Füllbrunn, Niels A W Lemmermann, Melanie M Brinkmann
The herpesviral antagonist m152 reveals differential activation of STING-dependent IRF and NF-κB signaling and STING's dual role during MCMV infection. The EMBO journal 38 (5) (2019)
Fabien G Lafaille, Oliver Harschnitz, Yoon Seung Lee, Peng Zhang, Mary L Hasek, Gaspard Kerner, Yuval Itan, Osefame Ewaleifoh, Franck Rapaport, Thomas M Carlile, Madalina E Carter-Timofte, Dominik Paquet, A Kerry Dobbs, Bastian Zimmer, Daxing Gao, Maria F Rojas-Duran, Dylan Kwart, Vimel Rattina, Michael J Ciancanelli, Jessica L McAlpine, Lazaro Lorenzo, Soraya Boucherit, Flore Rozenberg, Rabih Halwani, Benoit Henry, Naima Amenzoui, Zobaida Alsum, Laura Marques, Joseph A Church, Saleh Al-Muhsen, Marc Tardieu, Ahmed Aziz Bousfiha, Soren Riis Paludan, Trine Hyrup Mogensen, Lluis Quintana-Murci, Marc Tessier-Lavigne, Gregory A Smith, Luigi Daniele Notarangelo, Lorenz Studer, Wendy Gilbert, Laurent Abel, Jean Laurent Casanova, Shen-Ying Zhang
Human SNORA31 variations impair cortical neuron-intrinsic immunity to HSV-1 and underlie herpes simplex encephalitis. Nature medicine 25 (12) (2019)
Soren Riis Paludan, Line S Reinert, Veit Hornung
DNA-stimulated cell death: implications for host defence, inflammatory diseases and cancer. Nature reviews. Immunology 19 (3) (2019)
Ramya Nandakumar, Roland Tschismarov, Rüdiger Klein, Thaneas Prabakaran, Abhichart Krissanaprasit, Ensieh Farahani, Bao-Cun Zhang, Sonia Assil, Amandine Martin, Wilhelm Bertrams, Christian K Holm, Andrea Ablasser, Tanja Klause, Martin K Thomsen, Bernd Schmeck, Kenneth A Howard, Thomas Henry, Kurt V Gothelf, Thomas Decker, Soren Riis Paludan
Intracellular bacteria engage a STING-TBK1-MVB12b pathway to enable paracrine cGAS-STING signalling. Nature microbiology 4 (4) (2019)
Madalina E Carter-Timofte, Anders F Hansen, Mette Christiansen, Soren Riis Paludan, Trine Hyrup Mogensen
Mutations in RNA Polymerase III genes and defective DNA sensing in adults with varicella-zoster virus CNS infection. Genes and immunity 20 (3) (2018)
Morten Kelder Skouboe, Alice Knudsen, Line S Reinert, Cedric Boularan, Thierry Lioux, Eric Perouzel, Martin K Thomsen, Soren Riis Paludan
STING agonists enable antiviral cross-talk between human cells and confer protection against genital herpes in mice. PLoS pathogens 14 (4) (2018)
Thaneas Prabakaran, Chiranjeevi Bodda, Christian Krapp, Bao-Cun Zhang, Maria H Christensen, Chenglong Sun, Line Reinert, Yujia Cai, Søren B Jensen, Morten K Skouboe, Jens R Nyengaard, Craig B Thompson, Robert Jan Lebbink, Ganes C Sen, Geert van Loo, Rikke Nielsen, Masaaki Komatsu, Lene N Nejsum, Martin R Jakobsen, Mads Gyrd-Hansen, Soren Riis Paludan
Attenuation of cGAS-STING signaling is mediated by a p62/SQSTM1-dependent autophagy pathway activated by TBK1. The EMBO journal 37 (8) (2018)
Kristina Eriksson, Alexandra Svensson, Alon S Hait, Kerstin Schlüter, Petra Tunbäck, Inger Nordström, Leonid Padyukov, Jan-Åke Liljeqvist, Trine H Mogensen, Soren Riis Paludan
Cutting Edge: Genetic Association between IFI16 Single Nucleotide Polymorphisms and Resistance to Genital Herpes Correlates with IFI16 Expression Levels and HSV-2-Induced IFN-β Expression. Journal of immunology (Baltimore, Md. : 1950) 199 (8) (2017)
Sonia Assil, Soren Riis Paludan
Live and let die: ZBP1 senses viral and cellular RNAs to trigger necroptosis. The EMBO journal 36 (17) (2017)
Stefanie Luecke, Andreas Holleufer, Maria H Christensen, Kasper L Jønsson, Gerardo A Boni, Lambert K Sørensen, Mogens Johannsen, Martin R Jakobsen, Rune Hartmann, Soren Riis Paludan
cGAS is activated by DNA in a length-dependent manner. EMBO reports 18 (10) (2017)
Maria H Christensen, Søren B Jensen, Juho J Miettinen, Stefanie Luecke, Thaneas Prabakaran, Line S Reinert, Thomas Mettenleiter, Zhijian J Chen, David M Knipe, Rozanne M Sandri-Goldin, Lynn W Enquist, Rune Hartmann, Trine H Mogensen, Stephen A Rice, Tuula A Nyman, Sampsa Matikainen, Soren Riis Paludan
HSV-1 ICP27 targets the TBK1-activated STING signalsome to inhibit virus-induced type I IFN expression. The EMBO journal 35 (13) (2016)
Marie B Iversen, Line S Reinert, Martin K Thomsen, Ieva Bagdonaite, Ramya Nandakumar, Natalia Cheshenko, Thaneas Prabakaran, Sergey Y Vakhrushev, Malgosha Krzyzowska, Sine K Kratholm, Fernando Ruiz-Perez, Steen V Petersen, Stanislas Goriely, Bo Martin Bibby, Kristina Eriksson, Jürgen Ruland, Allan R Thomsen, Betsy C Herold, Hans H Wandall, Sebastian Frische, Christian K Holm, Soren Riis Paludan
An innate antiviral pathway acting before interferons at epithelial surfaces. Nature immunology 17 (2) (2015)

Soren Riis Paludan.css-eqlu8i{font-size:small;padding-left:4px;} (S R Paludan, Soren R Paludan, Søren R Paludan, Søren Riis Paludan, Trine H Mogensen)

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Soren Riis Paludan (S R Paludan, Soren R Paludan, Søren R Paludan, Søren Riis Paludan, Trine H Mogensen)