Zhijian J Chen (Zhijian Chen)

Scopus Author ID ORCID

Publication Activity (10 Years)

Years Active: 2018-2024
Publications (10 Years): 22

Top Venues

Proceedings of the National Academy of Sciences of the United States of America

Science (New York, N.Y.)

Nature communications

Science advances

University of Texas Southwestern Medical Center at Dallas

University at Buffalo - The State University of New York (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

University of Texas Southwestern Medical Center at Dallas Jul 14 1997

United States

Professor :: Molecular Biology

Education History

University at Buffalo - The State University of New York

United States

PHD :: Biochemistry

Publications

Ugur Uslu, Lijun Sun, María Sofía Castelli, Amanda V Finck, Charles-Antoine Assenmacher, Regina M Young, Zhijian J Chen, Carl H June
The STING agonist IMSA101 enhances chimeric antigen receptor T cell function by inducing IL-18 secretion. Nature communications 15 (1) (2024)
Ugur Uslu, Lijun Sun, María Sofía Castelli, Amanda V Finck, Charles-Antoine Assenmacher, Regina M Young, Zhijian J Chen, Carl H June
The STING agonist IMSA101 enhances chimeric antigen receptor T cell function by inducing IL-18 secretion. Nature communications 15 (1) (2024)
Ruibo Zhao, Jinghe Zhang, Jialu Ma, Yali Qu, Zhenrong Yang, Zhinan Yin, Fengyin Li, Zhongjun Dong, Qinmiao Sun, Shu Zhu, Zhijian J Chen, Daxing Gao
cGAS-activated endothelial cell-T cell cross-talk initiates tertiary lymphoid structure formation. Science immunology 9 (98) (2024)
Tong Li, Seoyun Yum, Junjiao Wu, Minghao Li, Yafang Deng, Lijun Sun, Xiaoxia Zuo, Zhijian J Chen
cGAS activation in classical dendritic cells causes autoimmunity in TREX1-deficient mice. Proceedings of the National Academy of Sciences of the United States of America 121 (38) (2024)
Justin M Jenson, Tuo Li, Fenghe Du, Chee-Kwee Ea, Zhijian J Chen
Ubiquitin-like Conjugation by Bacterial cGAS Enhances Anti-phage Defence. Nature (2023)
Ning Yang, Yi Wang, Peihong Dai, Tuo Li, Christian Zierhut, Adrian Tan, Tuo Zhang, Jenny Zhaoying Xiang, Alban Ordureau, Hironori Funabiki, Zhijian J Chen, Liang Deng
Vaccinia E5 is a major inhibitor of the DNA sensor cGAS. Nature communications 14 (1) (2023)
Justin M Jenson, Tuo Li, Fenghe Du, Chee-Kwee Ea, Zhijian J Chen
Ubiquitin-like Conjugation by Bacterial cGAS Enhances Anti-phage Defence. Nature (2023)
You-Tong Wu, Yan Fang, Qi Wei, Heping Shi, Huiling Tan, Yafang Deng, Zhiqun Zeng, Jian Qiu, Chuo Chen, Lijun Sun, Zhijian J Chen
Tumor-targeted delivery of a STING agonist improvescancer immunotherapy. Proceedings of the National Academy of Sciences of the United States of America 119 (49) (2022)
Shengyan Gao, Matthew Esparza, Ishmael Dehghan, Vasilisa Aksenova, Ke Zhang, Kimberly Batten, Max B Ferretti, Bridget E Begg, Tolga Cagatay, Jerry W Shay, Adolfo García-Sastre, Elizabeth J Goldsmith, Zhijian J Chen, Mary Dasso, Kristen W Lynch, Melanie H Cobb, Beatriz M A Fontoura
Nuclear speckle integrity and function require TAO2 kinase. Proceedings of the National Academy of Sciences of the United States of America 119 (25) (2022)
Kyung-Min Lee, Chang-Ching Lin, Alberto Servetto, Joonbeom Bae, Vishal Kandagatla, Dan Ye, Gun Min Kim, Dhivya R Sudhan, Saurabh Mendiratta, Paula I Gonzalez Ericsson, Justin M Balko, Jeon Lee, Spencer Barnes, Venkat S Malladi, Siamak Tabrizi, Sangeetha M Reddy, Seoyun Yum, Ching-Wei Chang, Katherine E Hutchinson, Susan E Yost, Yuan Yuan, Zhijian J Chen, Yang-Xin Fu, Ariella B Hanker, Carlos L Arteaga
Epigenetic Repression of STING by MYC Promotes Immune Evasion and Resistance to Immune Checkpoint Inhibitors in Triple-Negative Breast Cancer. Cancer immunology research 10 (7) (2022)
Yan Fang, Pengcheng Sun, Xuping Xie, Mingjian Du, Fenghe Du, Jianfeng Ye, Birte K Kalveram, Jessica A Plante, Kenneth S Plante, Bo Li, Xiao-Chen Bai, Pei-Yong Shi, Zhijian J Chen
An antibody that neutralizes SARS-CoV-1 and SARS-CoV-2 by binding to a conserved spike epitope outside the receptor binding motif. Science immunology 7 (76) (2022)
Tuo Li, Tuozhi Huang, Mingjian Du, Xiang Chen, Fenghe Du, Junyao Ren, Zhijian J Chen
Phosphorylation and chromatin tethering prevent cGAS activation during mitosis. Science (New York, N.Y.) 371 (6535) (2021)
Ke Zhang, Lisa Miorin, Tadashi Makio, Ishmael Dehghan, Shengyan Gao, Yihu Xie, Hualin Zhong, Matthew Esparza, Thomas Kehrer, Anil Kumar, Tom C Hobman, Christopher Ptak, Boning Gao, John D Minna, Zhijian J Chen, Adolfo García-Sastre, Yi Ren, Richard W Wozniak, Beatriz M A Fontoura
Nsp1 protein of SARS-CoV-2 disrupts the mRNA export machinery to inhibit host gene expression. Science advances 7 (6) (2021)
Seoyun Yum, Minghao Li, Yan Fang, Zhijian J Chen
TBK1 recruitment to STING activates both IRF3 and NF-κB that mediate immune defense against tumors and viral infections. Proceedings of the National Academy of Sciences of the United States of America 118 (14) (2021)
Shuiqing Hu, Yan Fang, Xiang Chen, Tianlei Cheng, Miaoqing Zhao, Mingjian Du, Tuo Li, Minghao Li, Zhiqun Zeng, Yonglong Wei, Zhimin Gu, Conggang Zhang, Lijun Sun, Zhijian J Chen
cGAS restricts colon cancer development by protecting intestinal barrier integrity. Proceedings of the National Academy of Sciences of the United States of America 118 (23) (2021)
Tong Li, Seoyun Yum, Minghao Li, Xiang Chen, Xiaoxia Zuo, Zhijian J Chen
TBK1 recruitment to STING mediates autoinflammatory arthritis caused by defective DNA clearance. The Journal of experimental medicine 219 (1) (2021)
Hao Chen, Hao Chen, Jia-Min Zhang, Yumin Wang, Antoine Simoneau, Hui Yang, Arthur S Levine, Lee Zou, Zhijian J Chen, Li Lan
cGAS suppresses genomic instability as a decelerator of replication forks. Science advances 6 (42) (2020)
Bao-Cun Zhang, Ramya Nandakumar, Line S Reinert, Jinrong Huang, Anders Laustsen, Zong-Liang Gao, Cheng-Long Sun, Søren Beck Jensen, Anne Troldborg, Sonia Assil, Martin F Berthelsen, Carsten Scavenius, Yan Zhang, Samuel J Windross, David Olagnier, Thaneas Prabakaran, Chiranjeevi Bodda, Ryo Narita, Yujia Cai, Cong-Gang Zhang, Harald Alfred Stenmark, Christine M Doucet, Takeshi Noda, Zheng Guo, Raphaela Goldbach-Mansky, Rune Hartmann, Zhijian J Chen, Jan J Enghild, Rasmus O Bak, Martin K Thomsen, Soren Riis Paludan
STEEP mediates STING ER exit and activation of signaling. Nature immunology 21 (8) (2020)
Andrea Ablasser, Zhijian J Chen
cGAS in action: Expanding roles in immunity and inflammation. Science (New York, N.Y.) 363 (6431) (2019)
Mingjian Du, Zhijian J Chen
DNA-induced liquid phase condensation of cGAS activates innate immune signaling. Science (New York, N.Y.) 361 (6403) (2018)
Jing Tian, Jiaxi Wu, Xiang Chen, Tong Guo, Zhijian J Chen, Joseph L Goldstein, Michael S Brown
BHLHE40, a third transcription factor required for insulin induction of SREBP-1c mRNA in rodent liver. eLife 7 (2018)
Tuo Li, Zhijian J Chen
The cGAS-cGAMP-STING pathway connects DNA damage to inflammation, senescence, and cancer. The Journal of experimental medicine 215 (5) (2018)

Zhijian J Chen.css-eqlu8i{font-size:small;padding-left:4px;} (Zhijian Chen)

Publication Activity (10 Years)

Top Topics

Top Venues

Zhijian J Chen (Zhijian Chen)