Jan Rehwinkel

ORCID

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 35

Top Venues

Proceedings of the National Academy of Sciences of the United States of America

Nature immunology

The EMBO journal

Nature communications

Cancer Research UK

European Molecular Biology Laboratory (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

Cancer Research UK

United Kingdom

Postdoctoral Scientist :: LRI

Education History

European Molecular Biology Laboratory

Germany

PHD :: Gene Expression Unit

Publications

Justine E Roderick-Richardson, Sung-Eun Lim, Sakiko Suzuki, Mohd Hafiz Ahmad, Jonathan Selway, Reem Suleiman, Keshab Kumar Karna, Jesse Lehman, Joanne O'Donnell, Lucio H Castilla, Jonathan Maelfait, Jan Rehwinkel, Michelle A Kelliher
ZBP1 activation triggers hematopoietic stem and progenitor cell death resulting in bone marrow failure in mice. Proceedings of the National Academy of Sciences of the United States of America 121 (4) (2024)
Justine E Roderick-Richardson, Sung-Eun Lim, Sakiko Suzuki, Mohd Hafiz Ahmad, Jonathan Selway, Reem Suleiman, Keshab Kumar Karna, Jesse Lehman, Joanne O'Donnell, Lucio H Castilla, Jonathan Maelfait, Jan Rehwinkel, Michelle A Kelliher
ZBP1 activation triggers hematopoietic stem and progenitor cell death resulting in bone marrow failure in mice. Proceedings of the National Academy of Sciences of the United States of America 121 (4) (2024)
Justine E Roderick-Richardson, Sung-Eun Lim, Sakiko Suzuki, Mohd Hafiz Ahmad, Jonathan Selway, Reem Suleiman, Keshab Kumar Karna, Jesse Lehman, Joanne O'Donnell, Lucio H Castilla, Jonathan Maelfait, Jan Rehwinkel, Michelle A Kelliher
ZBP1 activation triggers hematopoietic stem and progenitor cell death resulting in bone marrow failure in mice. Proceedings of the National Academy of Sciences of the United States of America 121 (4) (2024)
Mads Gyrd-Hansen, Anna Kajaste-Rudnitski, Nicolas Manel, Jan Rehwinkel, Annemarthe G van der Veen, Matteo Iannacone
Advancements in pathogen immunity and signaling. Nature immunology 25 (8) (2024)
Justine E Roderick-Richardson, Sung-Eun Lim, Sakiko Suzuki, Mohd Hafiz Ahmad, Jonathan Selway, Reem Suleiman, Keshab Kumar Karna, Jesse Lehman, Joanne O'Donnell, Lucio H Castilla, Jonathan Maelfait, Jan Rehwinkel, Michelle A Kelliher
ZBP1 activation triggers hematopoietic stem and progenitor cell death resulting in bone marrow failure in mice. Proceedings of the National Academy of Sciences of the United States of America 121 (4) (2024)
Mads Gyrd-Hansen, Anna Kajaste-Rudnitski, Nicolas Manel, Jan Rehwinkel, Annemarthe G van der Veen, Matteo Iannacone
Advancements in pathogen immunity and signaling. Nature immunology (2024)
Justine E Roderick-Richardson, Sung-Eun Lim, Sakiko Suzuki, Mohd Hafiz Ahmad, Jonathan Selway, Reem Suleiman, Keshab Kumar Karna, Jesse Lehman, Joanne O'Donnell, Lucio H Castilla, Jonathan Maelfait, Jan Rehwinkel, Michelle A Kelliher
ZBP1 activation triggers hematopoietic stem and progenitor cell death resulting in bone marrow failure in mice. Proceedings of the National Academy of Sciences of the United States of America 121 (4) (2024)
Justine E Roderick-Richardson, Sung-Eun Lim, Sakiko Suzuki, Mohd Hafiz Ahmad, Jonathan Selway, Reem Suleiman, Keshab Kumar Karna, Jesse Lehman, Joanne O'Donnell, Lucio H Castilla, Jonathan Maelfait, Jan Rehwinkel, Michelle A Kelliher
ZBP1 activation triggers hematopoietic stem and progenitor cell death resulting in bone marrow failure in mice. Proceedings of the National Academy of Sciences of the United States of America 121 (4) (2024)
Justine E Roderick-Richardson, Sung-Eun Lim, Sakiko Suzuki, Mohd Hafiz Ahmad, Jonathan Selway, Reem Suleiman, Keshab Kumar Karna, Jesse Lehman, Joanne O'Donnell, Lucio H Castilla, Jonathan Maelfait, Jan Rehwinkel, Michelle A Kelliher
ZBP1 activation triggers hematopoietic stem and progenitor cell death resulting in bone marrow failure in mice. Proceedings of the National Academy of Sciences of the United States of America 121 (4) (2024)
Mads Gyrd-Hansen, Anna Kajaste-Rudnitski, Nicolas Manel, Jan Rehwinkel, Annemarthe G van der Veen, Matteo Iannacone
Advancements in pathogen immunity and signaling. Nature immunology 25 (8) (2024)
Jonathan Maelfait, Jan Rehwinkel
The Z-nucleic acid sensor ZBP1 in health and disease. The Journal of experimental medicine 220 (8) (2023)
Nina Đukić, Øyvind Strømland, Jonas Damgaard Elsborg, Deeksha Munnur, Kang Zhu, Marion Schuller, Chatrin Chatrin, Pulak Kar, Lena Duma, Osamu Suyari, Johannes Gregor Matthias Rack, Domagoj Baretić, Dorian Richard Kenneth Crudgington, Joséphine Groslambert, Gerissa Fowler, Sven Wijngaarden, Evgeniia A Prokhorova, Jan Rehwinkel, Herwig Schüler, Dmitri V Filippov, Sumana Sanyal, Dragana Ahel, Michael Lund Nielsen, Rebecca Smith, Ivan Ahel
PARP14 is a PARP with both ADP-ribosyl transferase and hydrolase activities. Science advances 9 (37) (2023)
Ruoshi Peng, Chris Kedong Wang, Xuan Wang-Kan, Manja Idorn, Majken Kjaer, Felix Yuran Zhou, Berthe Katrine Fiil, Frederik Timmermann, Susana L Orozco, Julia McCarthy, Carol S Leung, Xin Lu, Katrin Bagola, Jan Rehwinkel, Andrew Oberst, Jonathan Maelfait, Soren Riis Paludan, Mads Gyrd-Hansen
Human ZBP1 induces cell death-independent inflammatory signaling via RIPK3 and RIPK1. EMBO reports 23 (12) (2022)
Pamela J Shaw, Valerie Odon, Calum Harvey, Mark O Collins, Andrew Peden, John Franklin, Emily Graves, Jack Ng Marshall, Cleide Dos Santos Souza, Sai Zhang, Lydia Castelli, Guillaume M Hautbergue, Mimoun Azzouz, David Gordon, Nevan J Krogan, Laura Ferraiuolo, Michael P Snyder, Pamela J Shaw, Jan Rehwinkel, Johnathan Cooper-Knock
Low expression of EXOSC2 protects against clinical COVID-19 and impedes SARS-CoV-2 replication. Life science alliance 6 (1) (2022)
Jonny Hertzog, Wen Zhou, Gerissa Fowler, Rachel E Rigby, Anne Bridgeman, Henry Tw Blest, Chiara Cursi, Lise Chauveau, Tamara Davenne, Benjamin E Warner, Paul R Kinchington, Philip J Kranzusch, Jan Rehwinkel
Varicella-Zoster virus ORF9 is an antagonist of the DNA sensor cGAS. The EMBO journal 41 (14) (2022)
Thomas Clapes, Aikaterini Polyzou, Pia Prater, null Sagar, Antonio Morales-Hernández, Mariana Galvão Ferrarini, Natalie Kehrer, Stylianos Lefkopoulos, Veronica Bergo, Barbara Hummel, Nadine Obier, Daniel Maticzka, Anne Bridgeman, Josip Stefan Herman, Ibrahim Ilik, Lhéanna Klaeylé, Jan Rehwinkel, Shannon McKinney-Freeman, Rolf Backofen, Asifa Akhtar, Nina Cabezas-Wallscheid, Ritwick Sawarkar, Rita Rebollo, Dominic Grün, Eirini Trompouki
Publisher Correction: Chemotherapy-induced transposable elements activate MDA5 to enhance haematopoietic regeneration. Nature cell biology (2021)
Karol Nienałtowski, Rachel E Rigby, Jarosław Walczak, Karolina E Zakrzewska, Edyta Głów, Jan Rehwinkel, Michał Komorowski
Fractional response analysis reveals logarithmic cytokine responses in cellular populations. Nature communications 12 (1) (2021)
Lise Chauveau, Anne Bridgeman, Tiong K Tan, Ryan Beveridge, Joe N Frost, Pramila Rijal, Isabela Pedroza-Pacheco, Thomas Partridge, Javier Gilbert-Jaramillo, Michael L Knight, Xu Liu, Rebecca A Russell, Persephone Borrow, Hal Drakesmith, Alain R Townsend, Jan Rehwinkel
Inclusion of cGAMP within virus-like particle vaccines enhances their immunogenicity. EMBO reports 22 (8) (2021)
Thomas Clapes, Aikaterini Polyzou, Pia Prater, null Sagar, Antonio Morales-Hernández, Mariana Galvão Ferrarini, Natalie Kehrer, Stylianos Lefkopoulos, Veronica Bergo, Barbara Hummel, Nadine Obier, Daniel Maticzka, Anne Bridgeman, Josip Stefan Herman, Ibrahim Ilik, Lhéanna Klaeylé, Jan Rehwinkel, Shannon McKinney-Freeman, Rolf Backofen, Asifa Akhtar, Nina Cabezas-Wallscheid, Ritwick Sawarkar, Rita Rebollo, Dominic Grün, Eirini Trompouki
Chemotherapy-induced transposable elements activate MDA5 to enhance haematopoietic regeneration. Nature cell biology 23 (7) (2021)
Natalia G Sampaio, Lise Chauveau, Jonny Hertzog, Anne Bridgeman, Gerissa Fowler, Jurgen P Moonen, Maeva Dupont, Rebecca A Russell, Marko Noerenberg, Jan Rehwinkel
The RNA sensor MDA5 detects SARS-CoV-2 infection. Scientific reports 11 (1) (2021)
Jan Rehwinkel, Michaela U Gack
RIG-I-like receptors: their regulation and roles in RNA sensing. Nature reviews. Immunology 20 (9) (2020)
Mutian Jia, Danhui Qin, Chunyuan Zhao, Li Chai, Zhongxia Yu, Wenwen Wang, Li Tong, Lin Lv, Yuanyuan Wang, Jan Rehwinkel, Jinming Yu, Wei Zhao
Redox homeostasis maintained by GPX4 facilitates STING activation. Nature immunology 21 (7) (2020)
Jonny Hertzog, Jan Rehwinkel
Regulation and inhibition of the DNA sensor cGAS. EMBO reports 21 (12) (2020)
Gennaro Prota, Uzi Gileadi, Margarida Rei, Ana Victoria Lechuga-Vieco, Ji-Li Chen, Silvia Galiani, Melissa Bedard, Vivian Wing Chong Lau, Lorenzo F Fanchi, Mara Artibani, Zhiyuan Hu, Siamon Gordon, Jan Rehwinkel, José Antonio Enríquez, Ahmed A Ahmed, Ton N Schumacher, Vincenzo Cerundolo
Enhanced Immunogenicity of Mitochondrial-Localized Proteins in Cancer Cells. Cancer immunology research 8 (5) (2020)
Ana Miar, Esther Arnaiz, Esther Bridges, Shaunna Beedie, Adam P Cribbs, Damien J Downes, Robert A Beagrie, Jan Rehwinkel, Adrian L Harris
Hypoxia Induces Transcriptional and Translational Downregulation of the Type I IFN Pathway in Multiple Cancer Cell Types. Cancer research 80 (23) (2020)
Afzal Husain, Jianliang Xu, Hodaka Fujii, Mikiyo Nakata, Maki Kobayashi, Ji-Yang Wang, Jan Rehwinkel, Tasuku Honjo, Nasim A Begum
SAMHD1-mediated dNTP degradation is required for efficient DNA repair during antibody class switch recombination. The EMBO journal 39 (15) (2020)
Mirjam Schilling, Anne Bridgeman, Nicki Gray, Jonny Hertzog, Philip Hublitz, Alain Kohl, Jan Rehwinkel
RIG-I Plays a Dominant Role in the Induction of Transcriptional Changes in Zika Virus-Infected Cells, which Protect from Virus-Induced Cell Death. Cells 9 (6) (2020)
David Olagnier, Ensieh Farahani, Jacob Thyrsted, Julia Blay-Cadanet, Angela Herengt, Manja Idorn, Alon Hait, Bruno Hernaez, Alice Knudsen, Marie Beck Iversen, Mirjam Schilling, Sofie E Jørgensen, Michelle Thomsen, Line S Reinert, Michael Lappe, Huy-Dung Hoang, Victoria H Gilchrist, Anne Louise Hansen, Rasmus Ottosen, Camilla G Nielsen, Charlotte Møller, Demi van der Horst, Suraj Peri, Siddharth Balachandran, Jinrong Huang, Martin Roelsgaard Jakobsen, Esben B Svenningsen, Thomas B Poulsen, Lydia Bartsch, Anne L Thielke, Yonglun Luo, Tommy Alain, Jan Rehwinkel, Antonio Alcami, John Hiscott, Trine H Mogensen, Soren Riis Paludan, Christian Kanstrup Holm
Author Correction: SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate. Nature communications 11 (1) (2020)
David Olagnier, Ensieh Farahani, Jacob Thyrsted, Julia Blay-Cadanet, Angela Herengt, Manja Idorn, Alon Hait, Bruno Hernaez, Alice Knudsen, Marie Beck Iversen, Mirjam Schilling, Sofie E Jørgensen, Michelle Thomsen, Line S Reinert, Michael Lappe, Huy-Dung Hoang, Victoria H Gilchrist, Anne Louise Hansen, Rasmus Ottosen, Camilla G Nielsen, Charlotte Møller, Demi van der Horst, Suraj Peri, Siddharth Balachandran, Jinrong Huang, Martin Roelsgaard Jakobsen, Esben B Svenningsen, Thomas B Poulsen, Lydia Bartsch, Anne L Thielke, Yonglun Luo, Tommy Alain, Jan Rehwinkel, Antonio Alcami, John Hiscott, Trine H Mogensen, Soren Riis Paludan, Christian Kanstrup Holm
SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate. Nature communications 11 (1) (2020)
Tamara Davenne, Jan Rehwinkel
PNP inhibitors selectively kill cancer cells lacking SAMHD1. Molecular & cellular oncology 7 (6) (2020)
Peter A C Wing, Tamara Davenne, Jochen Wettengel, Alvina G Lai, Xiaodong Zhuang, Anindita Chakraborty, Valentina D'Arienzo, Catharina Kramer, Chunkyu Ko, James M Harris, Sabrina Schreiner, Martin R Higgs, Stephanie Roessler, Joanna L Parish, Ulrike Protzer, Peter Balfe, Jan Rehwinkel, Jane A McKeating
A dual role for SAMHD1 in regulating HBV cccDNA and RT-dependent particle genesis. Life science alliance 2 (2) (2019)
Tamara Davenne, Anne Bridgeman, Rachel E Rigby, Jan Rehwinkel
Deoxyguanosine is a TLR7 agonist. European journal of immunology 50 (1) (2019)
Jonny Hertzog, Antonio Gregorio Dias Junior, Rachel E Rigby, Claire L Donald, Alice Mayer, Erdinc Sezgin, Chaojun Song, Boquan Jin, Philip Hublitz, Christian Eggeling, Alain Kohl, Jan Rehwinkel
Infection with a Brazilian isolate of Zika virus generates RIG-I stimulatory RNA and the viral NS5 protein blocks type I IFN induction and signaling. European journal of immunology 48 (7) (2018)
Anne Louise Hansen, Gregory J Buchan, Michael Rühl, Kojiro Mukai, Sonia R Salvatore, Emari Ogawa, Sidsel D Andersen, Marie B Iversen, Anne L Thielke, Camilla Gunderstofte, Mona Motwani, Charlotte T Møller, Andreas S Jakobsen, Katherine A Fitzgerald, Jessica Roos, Rongtuan Lin, Thorsten J Maier, Raphaela Goldbach-Mansky, Cathrine A Miner, Wei Qian, Jonathan J Miner, Rachel E Rigby, Jan Rehwinkel, Martin R Jakobsen, Hiroyuki Arai, Tomohiko Taguchi, Francisco J Schopfer, David Olagnier, Christian K Holm
Nitro-fatty acids are formed in response to virus infection and are potent inhibitors of STING palmitoylation and signaling. Proceedings of the National Academy of Sciences of the United States of America 115 (33) (2018)
Jonathan Maelfait, Layal Liverpool, Anne Bridgeman, Katherine B Ragan, Jason W Upton, Jan Rehwinkel
Sensing of viral and endogenous RNA by ZBP1/DAI induces necroptosis. The EMBO journal 36 (17) (2017)

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Publication Activity (10 Years)

Top Topics

Top Venues

Jan Rehwinkel