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Stefan Rose-John

ResearcherID ORCID

Publication Activity (10 Years)

Years Active: 2016-2023
Publications (10 Years): 33

Top Venues

Cells

Journal of immunology (Baltimore, Md. : 1950)

Nature communications

International journal of molecular sciences

University of Kiel

University of Heidelberg (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

University of Kiel Apr 1o 2000

Germany

Professor and Head :: Biochemistry

Education History

University of Heidelberg Oct 15o 1973 - May 10o 1982

Germany

PHD :: Biology

Publications

Lisa Charlotte Heinig, Emily Valentina Madelaine Huth, Karsten Yan, Neele Schumacher, Mikolaj Nawrocki, Niels Christian Lory, Peter Bradtke, Tabea Bertram, Guido Rattay, Joanna Schmid, Samuel Huber, Thorsten Wiech, Dirk Schmidt-Arras, Stefan Rose-John, Hans-Willi Mittrücker
Cell-Autonomous Constitutive gp130 Signaling in T Cells Amplifies TH17 Cell Responses and Causes Severe Lung Inflammation. Journal of immunology (Baltimore, Md. : 1950) (2023)
Stefan Rose-John, Brendan J Jenkins, Christoph Garbers, Jens M Moll, Jürgen Scheller
Targeting IL-6 trans-signalling: past, present and future prospects. Nature reviews. Immunology (2023)
Puyan Rafii, Friedrich Reusswig, Julia Werner, Haifeng Xu, Philipp A Lang, Stefan Rose-John, Simone Gorressen, Christina Alter, Jürgen Schrader, Diran Herebian, Doreen M Floss, Margitta Elvers, Roland P Piekorz, Jürgen Scheller, Kristina Behnke
Constitutive Activation of gp130 in T Cells Results in Senescence and Premature Aging. Journal of immunology (Baltimore, Md. : 1950) (2023)
Ebru Boslem, Saskia Reibe, Rodrigo Carlessi, Benoit Smeuninx, Surafel Tegegne, Casey L Egan, Emma McLennan, Lauren V Terry, Max Nobis, Andre Mu, Cameron J Nowell, Neil U Horadagoda, Natalie A Mellett, Paul Timpson, Matthew Jones, Elena Denisenko, Alistair R R Forrest, Janina E E Tirnitz-Parker, Peter J Meikle, Stefan Rose-John, Michael Karin, Mark A Febbraio
Therapeutic blockade of ER stress and inflammation prevents NASH and progression to HCC. Science advances 9 (37) (2023)
Mor Paldor, Orr Levkovitch-Siany, Dana Eidelshtein, Revital Adar, Claes D Enk, Yitzhak Marmary, Sharona Elgavish, Yuval Nevo, Hadar Benyamini, Inbar Plaschkes, Shiri Klein, Alex Mali, Stefan Rose-John, Amnon Peled, Eithan Galun, Jonathan H Axelrod
Single-cell transcriptomics reveals a senescence-associated IL-6/CCR6 axis driving radiodermatitis. EMBO molecular medicine 14 (8) (2022)
Miryam Müller, Claire Saunders, Anke Senftleben, Johannes P W Heidbuechel, Birgit Halwachs, Julia Bolik, Nina Hedemann, Christian Röder, Dirk Bauerschlag, Stefan Rose-John, Dirk Schmidt-Arras
Tetraspanin 8 Subfamily Members Regulate Substrate-Specificity of a Disintegrin and Metalloprotease 17. Cells 11 (17) (2022)
Mohamed I Saad, Teresa Weng, Joanne Lundy, Linden J Gearing, Alison C West, Christopher M Harpur, Mohammad Alanazi, Christopher Hodges, Daniel Croagh, Beena Kumar, Irit Sagi, Stefan Rose-John, Brendan J Jenkins
Blockade of the protease ADAM17 ameliorates experimental pancreatitis. Proceedings of the National Academy of Sciences of the United States of America 119 (42) (2022)
Torben Mentrup, Anna Yamina Stumpff-Niggemann, Nadja Leinung, Christine Schlosser, Katja Schubert, Rebekka Wehner, Antje Tunger, Valentin Schatz, Patrick Neubert, Ann-Christine Gradtke, Janina Wolf, Stefan Rose-John, Paul Saftig, Alexander Dalpke, Jonathan Jantsch, Marc Schmitz, Regina Fluhrer, Ilse D Jacobsen, Bernd Schröder
Phagosomal signalling of the C-type lectin receptor Dectin-1 is terminated by intramembrane proteolysis. Nature communications 13 (1) (2022)
Saleela M Ruwanpura, Louise McLeod, Lovisa F Dousha, Huei J Seow, Alison C West, Alice J West, Teresa Weng, Mohammad Alanazi, Martin I MacDonald, Paul T King, Philip G Bardin, Cem Gabay, Dennis M Klinman, Steven Bozinovski, Ross Vlahos, Gary P Anderson, Stefan Rose-John, Mohamed I Saad, Brendan J Jenkins
Cross-talk between IL-6 trans-signaling and AIM2 inflammasome/IL-1β axes bridge innate immunity and epithelial apoptosis to promote emphysema. Proceedings of the National Academy of Sciences of the United States of America 119 (36) (2022)
Tor Henrik Anderson Tvedt, Stefan Rose-John, Galina Tsykunova, Aymen Bushra Ahmed, Tobias Gedde-Dahl, Elisabeth Ersvær, Øystein Bruserud
IL-6 Responsiveness of CD4 + and CD8 + T Cells after Allogeneic Stem Cell Transplantation Differs between Patients and Is Associated with Previous Acute Graft versus Host Disease and Pretransplant Antithymocyte Globulin Therapy. Journal of clinical medicine 11 (9) (2022)
Edoardo Del Poggetto, I-Lin Ho, Chiara Balestrieri, Er-Yen Yen, Shaojun Zhang, Francesca Citron, Rutvi Shah, Denise Corti, Giuseppe Riccardo Diaferia, Chieh-Yuan Li, Sara Loponte, Federica Carbone, Yoku Hayakawa, Giovanni Valenti, Shan Jiang, Luigi Sapio, Hong Jiang, Prasenjit Dey, Sisi Gao, Angela K Deem, Stefan Rose-John, Wantong Yao, Haoqiang Ying, Andrew D Rhim, Giannicola Genovese, Timothy P Heffernan, Anirban Maitra, Timothy C Wang, Linghua Wang, Giulio F Draetta, Alessandro Carugo, Gioacchino Natoli, Andrea Viale
Epithelial memory of inflammation limits tissue damage while promoting pancreatic tumorigenesis. Science (New York, N.Y.) 373 (6561) (2021)
Stefan Rose-John
Local and systemic effects of interleukin-6 (IL-6) in inflammation and cancer. FEBS letters (2021)
Lilli Otto, Sascha Rahn, Tina Daunke, Frederik Walter, Elsa Winter, Julia Luisa Möller, Stefan Rose-John, Daniela Wesch, Heiner Schäfer, Susanne Sebens
Initiation of Pancreatic Cancer: The Interplay of Hyperglycemia and Macrophages Promotes the Acquisition of Malignancy-Associated Properties in Pancreatic Ductal Epithelial Cells. International journal of molecular sciences 22 (10) (2021)
Jürgen Fritsch, Julia Frankenheim, Lothar Marischen, Timea Vadász, Anja Troeger, Stefan Rose-John, Dirk Schmidt-Arras, Wulf Schneider-Brachert
Roles for ADAM17 in TNF-R1 Mediated Cell Death and Survival in Human U937 and Jurkat Cells. Cells 10 (11) (2021)
Marco Heestermans, Clément Naudin, Reiner K Mailer, Sandra Konrath, Kristin Klaetschke, Anne Jämsä, Maike Frye, Carsten Deppermann, Giordano Pula, Piotr Kuta, Nicolaus Kröger, Mathias Gelderblom, Albert Sickmann, Roger J S Preston, Jerzy-Roch Nofer, Stefan Rose-John, Lynn M Butler, Ophira Salomon, Evi X Stavrou, Thomas Renne
Identification of the factor XII contact activation site enables sensitive coagulation diagnostics. Nature communications 12 (1) (2021)
Kristin Koerdel, Melanie Spitzner, Thomas Meyer, Niklas Engels, Florian Krause, Jochen Gaedcke, Lena-Christin Conradi, Martin Haubrock, Tim Beißbarth, Andreas Leha, Steven A Johnsen, B Michael Ghadimi, Stefan Rose-John, Marian Grade, Jürgen Wienands
NOTCH Activation via gp130/STAT3 Signaling Confers Resistance to Chemoradiotherapy. Cancers 13 (3) (2021)
Saida Breuer, Philipp Kasper, Christina Vohlen, Ruth Janoschek, Thorben Hoffmann, Sarah Appel, Elena Müller-Limberger, Andrea Mesaros, Stefan Rose-John, Christoph Garbers, Stefan Müller, Jan-Wilm Lackmann, Esther Mahabir, Jörg Dötsch, Eva Hucklenbruch-Rother, Inga Bae-Gartz
Brain-Restricted Inhibition of IL-6 Trans-Signaling Mildly Affects Metabolic Consequences of Maternal Obesity in Male Offspring. Nutrients 13 (11) (2021)
Julia Bolik, Freia Krause, Marija Stevanovic, Monja Gandraß, Ilka Thomsen, Sarah-Sophie Schacht, Eva Rieser, Miryam Müller, Neele Schumacher, Jürgen Fritsch, Rielana Wichert, Eithan Galun, Juri Bergmann, Christian Röder, Clemens Schafmayer, Jan-Hendrik Egberts, Christoph Becker-Pauly, Paul Saftig, Ralph Lucius, Wulf Schneider-Brachert, Roja Barikbin, Dieter Adam, Matthias Voss, Wolfgang Hitzl, Achim Krüger, Boris Strilic, Irit Sagi, Henning Walczak, Stefan Rose-John, Dirk Schmidt-Arras
Inhibition of ADAM17 impairs endothelial cell necroptosis and blocks metastasis. The Journal of experimental medicine 219 (1) (2021)
Maria D Giraldez, David Carneros, Christoph Garbers, Stefan Rose-John, Matilde Bustos
New insights into IL-6 family cytokines in metabolism, hepatology and gastroenterology. Nature reviews. Gastroenterology & hepatology 18 (11) (2021)
Jan Philipp Dobert, Anne-Sophie Cabron, Philipp Arnold, Egor Pavlenko, Stefan Rose-John, Friederike Zunke
Functional Characterization of Colon-Cancer-Associated Variants in ADAM17 Affecting the Catalytic Domain. Biomedicines 8 (11) (2020)
Anibal Garza Carbajal, Andrea Ebersberger, Alina Thiel, Luiz Ferrari, Jeremy Acuna, Stephanie Brosig, Joerg Isensee, Katharina Moeller, Maike Siobal, Stefan Rose-John, Jon Levine, Hans-Georg Schaible, Tim Hucho
Oncostatin M induces hyperalgesic priming and amplifies signaling of cAMP to ERK by RapGEF2 and PKA. Journal of neurochemistry 157 (6) (2020)
Tobias Schwerd, Freia Krause, Stephen R F Twigg, Dominik Aschenbrenner, Yin-Huai Chen, Uwe Borgmeyer, Miryam Müller, Santiago Manrique, Neele Schumacher, Steven A Wall, Jonathan Jung, Timo Damm, Claus-Christian Glüer, Jürgen Scheller, Stefan Rose-John, Edith Yvonne Jones, Arian Laurence, Andrew O M Wilkie, Dirk Schmidt-Arras, Holm H Uhlig
A variant in IL6ST with a selective IL-11 signaling defect in human and mouse. Bone research 8 (1) (2020)
Philipp Arnold, Wiebke Lückstädt, Wenjia Li, Inga Boll, Juliane Lokau, Christoph Garbers, Ralph Lucius, Stefan Rose-John, Christoph Becker-Pauly
Joint Reconstituted Signaling of the IL-6 Receptor via Extracellular Vesicles. Cells 9 (5) (2020)
Neele Schumacher, Stefan Rose-John, Dirk Schmidt-Arras
ADAM-Mediated Signalling Pathways in Gastrointestinal Cancer Formation. International journal of molecular sciences 21 (14) (2020)
Anna Escrig, Amalia Molinero, Brenda Méndez, Mercedes Giralt, Gemma Comes, Paula Sanchis, Olaya Fernández-Gayol, Lydia Giménez-Llort, Christoph Becker-Pauly, Stefan Rose-John, Juan Hidalgo
IL-6 Trans-Signaling in the Brain Influences the Metabolic Phenotype of the 3xTg-AD Mouse Model of Alzheimer's Disease. Cells 9 (7) (2020)
Melanie Werner-Klein, Ana Grujovic, Christoph Irlbeck, Milan Obradović, Martin Hoffmann, Huiqin Koerkel-Qu, Xin Lu, Steffi Treitschke, Cäcilia Köstler, Catherine Botteron, Kathrin Weidele, Christian Werno, Bernhard Polzer, Stefan Kirsch, Miodrag Gužvić, Jens Warfsmann, Kamran Honarnejad, Zbigniew Czyz, Giancarlo Feliciello, Isabell Blochberger, Sandra Grunewald, Elisabeth Schneider, Gundula Haunschild, Nina Patwary, Severin Guetter, Sandra Huber, Brigitte Rack, Nadia Harbeck, Stefan Buchholz, Petra Rümmele, Norbert Heine, Stefan Rose-John, Christoph A Klein
Interleukin-6 trans-signaling is a candidate mechanism to drive progression of human DCCs during clinical latency. Nature communications 11 (1) (2020)
Tobias Schwerd, Freia Krause, Stephen R F Twigg, Dominik Aschenbrenner, Yin-Huai Chen, Uwe Borgmeyer, Miryam Müller, Santiago Manrique, Neele Schumacher, Steven A Wall, Jonathan Jung, Timo Damm, Claus-Christian Glüer, Jürgen Scheller, Stefan Rose-John, Edith Yvonne Jones, Arian Laurence, Andrew O M Wilkie, Dirk Schmidt-Arras, Holm H Uhlig
A variant in IL6ST with a selective IL-11 signaling defect in human and mouse. Bone research 8 (2020)
Dirk Schmidt-Arras, Stefan Rose-John
Regulation of Fibrotic Processes in the Liver by ADAM Proteases. Cells 8 (10) (2019)
Egor Pavlenko, Anne-Sophie Cabron, Philipp Arnold, Jan Philipp Dobert, Stefan Rose-John, Friederike Zunke
Functional Characterization of Colon Cancer-Associated Mutations in ADAM17: Modifications in the Pro-Domain Interfere with Trafficking and Maturation. International journal of molecular sciences 20 (9) (2019)
Anne-Sophie Cabron, Karim El Azzouzi, Melanie Boss, Philipp Arnold, Jeanette Schwarz, Marcela Rosas, Jan Philipp Dobert, Egor Pavlenko, Neele Schumacher, Thomas Renné, Philip R Taylor, Stefan Linder, Stefan Rose-John, Friederike Zunke
Structural and Functional Analyses of the Shedding Protease ADAM17 in HoxB8-Immortalized Macrophages and Dendritic-like Cells. Journal of immunology (Baltimore, Md. : 1950) 201 (10) (2018)
Felix R Stahl, Roman Jung, Virginija Jazbutyte, Eléonore Ostermann, Silvia Tödter, Renke Brixel, Annette Kemmer, Stephan Halle, Stefan Rose-John, Martin Messerle, Petra C Arck, Wolfram Brune, Thomas Renné
Laboratory diagnostics of murine blood for detection of mouse cytomegalovirus (MCMV)-induced hepatitis. Scientific reports 8 (1) (2018)
Stefanie Schmidt, Neele Schumacher, Jeanette Schwarz, Simone Tangermann, Lukas Kenner, Michaela Schlederer, Maria Sibilia, Markus Linder, Annelore Altendorf-Hofmann, Thomas Knösel, Elisabeth S Gruber, Georg Oberhuber, Julia Bolik, Ateequr Rehman, Anupam Sinha, Juliane Lokau, Philipp Arnold, Anne-Sophie Cabron, Friederike Zunke, Christoph Becker-Pauly, Adele Preaudet, Paul Nguyen, Jennifer Huynh, Shoukat Afshar-Sterle, Ashwini L Chand, Jürgen Westermann, Peter J Dempsey, Christoph Garbers, Dirk Schmidt-Arras, Philip C Rosenstiel, Tracy Putoczki, Matthias Ernst, Stefan Rose-John
ADAM17 is required for EGF-R-induced intestinal tumors via IL-6 trans-signaling. The Journal of experimental medicine 215 (4) (2018)
Neele Schumacher, Stefanie Schmidt, Jeanette Schwarz, Dana Dohr, Juliane Lokau, Jürgen Scheller, Christoph Garbers, Athena Chalaris, Stefan Rose-John, Björn Rabe
Circulating Soluble IL-6R but Not ADAM17 Activation Drives Mononuclear Cell Migration in Tissue Inflammation. Journal of immunology (Baltimore, Md. : 1950) 197 (9) (2016)

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Publication Activity (10 Years)

Top Topics

Top Venues

Stefan Rose-John