Stephen Fowler

Scopus Author ID ORCID

Publication Activity (10 Years)

Years Active: 2020-2024
Publications (10 Years): 20

Top Venues

Drug metabolism and disposition: the biological fate of chemicals

CPT: pharmacometrics & systems pharmacology

Lab on a chip

Clinical pharmacology and therapeutics

F Hoffmann-La Roche AG

University of Dundee (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

F Hoffmann-La Roche AG Feb 01 2003

Switzerland

Group Leader, In Vitro Enzymology and DDI :: Drug Metabolism

Education History

University of Dundee Sep 01 1994 - Dec 20 1997

United Kingdom

PHD :: Biomedical Research Centre

Publications

Agustos Cetin Ozbey, Janneke Keemink, Bjoern Wagner, Alessandra Pugliano, Stephan Krähenbühl, Pieter Annaert, Stephen Fowler, Neil Parrott, Kenichi Umehara
Physiologically based pharmacokinetic modeling to predict the impact of liver cirrhosis on glucuronidation via UGT1A4 & UGT2B7/2B4 - a case study with midazolam. Drug metabolism and disposition: the biological fate of chemicals (2024)
Nicoló Milani, Neil John Parrott, Aleksandra Galetin, Stephen Fowler, Michael Gertz
In silico modeling and simulation of organ-on-a-chip systems to support data analysis and a priori experimental design. CPT: pharmacometrics & systems pharmacology 13 (4) (2024)
Agustos Cetin Ozbey, Janneke Keemink, Bjoern Wagner, Alessandra Pugliano, Stephan Krähenbühl, Pieter Annaert, Stephen Fowler, Neil Parrott, Kenichi Umehara
Physiologically Based Pharmacokinetic Modeling to Predict the Impact of Liver Cirrhosis on Glucuronidation via UGT1A4 and UGT2B7/2B4-A Case Study with Midazolam. Drug metabolism and disposition: the biological fate of chemicals 52 (7) (2024)
Nicoló Milani, Neil John Parrott, Aleksandra Galetin, Stephen Fowler, Michael Gertz
In silico modeling and simulation of organ-on-a-chip systems to support data analysis and a priori experimental design. CPT: pharmacometrics & systems pharmacology 13 (4) (2024)
Agustos Cetin Ozbey, Janneke Keemink, Bjoern Wagner, Alessandra Pugliano, Stephan Krähenbühl, Pieter Annaert, Stephen Fowler, Neil Parrott, Kenichi Umehara
Physiologically Based Pharmacokinetic Modeling to Predict the Impact of Liver Cirrhosis on Glucuronidation via UGT1A4 and UGT2B7/2B4-A Case Study with Midazolam. Drug metabolism and disposition: the biological fate of chemicals 52 (7) (2024)
Nicoló Milani, Neil John Parrott, Aleksandra Galetin, Stephen Fowler, Michael Gertz
In silico modeling and simulation of organ-on-a-chip systems to support data analysis and a priori experimental design. CPT: pharmacometrics & systems pharmacology (2024)
Nicoló Milani, Neil John Parrott, Aleksandra Galetin, Stephen Fowler, Michael Gertz
In silico modeling and simulation of organ-on-a-chip systems to support data analysis and a priori experimental design. CPT: pharmacometrics & systems pharmacology 13 (4) (2024)
Nicoló Milani, Neil John Parrott, Aleksandra Galetin, Stephen Fowler, Michael Gertz
In silico modeling and simulation of organ-on-a-chip systems to support data analysis and a priori experimental design. CPT: pharmacometrics & systems pharmacology 13 (4) (2024)
Agustos Cetin Ozbey, Janneke Keemink, Bjoern Wagner, Alessandra Pugliano, Stephan Krähenbühl, Pieter Annaert, Stephen Fowler, Neil Parrott, Kenichi Umehara
Physiologically Based Pharmacokinetic Modeling to Predict the Impact of Liver Cirrhosis on Glucuronidation via UGT1A4 and UGT2B7/2B4-A Case Study with Midazolam. Drug metabolism and disposition: the biological fate of chemicals 52 (7) (2024)
Nicoló Milani, Neil John Parrott, Aleksandra Galetin, Stephen Fowler, Michael Gertz
In silico modeling and simulation of organ-on-a-chip systems to support data analysis and a priori experimental design. CPT: pharmacometrics & systems pharmacology 13 (4) (2024)
Agustos Cetin Ozbey, Stephen Fowler, Karen Leys, Pieter Annaert, Kenichi Umehara, Neil Parrott
PBPK Modelling for Drugs Cleared by Non-CYP Enzymes: State-of-the-Art and Future Perspectives. Drug metabolism and disposition: the biological fate of chemicals (2023)
Agustos C Ozbey, Fabio Bachmann, Urs Duthaler, Pieter Annaert, Stephen Fowler, Kenichi Umehara, Neil Parrott, Stephan Krähenbühl
Dose adjustment in patients with liver cirrhosis - comparison of two different modeling approaches. Clinical pharmacology and therapeutics (2023)
Nicolò Milani, NaHong Qiu, Stephen Fowler
Contribution of UGT Enzymes to Human Drug Metabolism Stereoselectivity: A Case Study of Medetomidine, RO5263397, Propranolol, and Testosterone. Drug metabolism and disposition: the biological fate of chemicals 51 (3) (2022)
Luca Docci, Nicoló Milani, Thomas Ramp, Andrea A Romeo, Patricio Godoy, Daniela Ortiz Franyuti, Stephan Krähenbühl, Michael Gertz, Aleksandra Galetin, Neil Parrott, Stephen Fowler
Exploration and application of a liver-on-a-chip device in combination with modelling and simulation for quantitative drug metabolism studies. Lab on a chip 22 (6) (2022)
Nicoló Milani, Neil Parrott, Daniela Ortiz Franyuti, Patricio Godoy, Aleksandra Galetin, Michael Gertz, Stephen Fowler
Application of a gut-liver-on-a-chip device and mechanistic modelling to the quantitative in vitro pharmacokinetic study of mycophenolate mofetil. Lab on a chip 22 (15) (2022)
Nicolò Milani, NaHong Qiu, Stephen Fowler
Contribution of UGT Enzymes to Human Drug Metabolism Stereoselectivity: A Case Study of Medetomidine, RO5263397, Propranolol, and Testosterone. Drug metabolism and disposition: the biological fate of chemicals 51 (3) (2022)
Nicolò Milani, NaHong Qiu, Stephen Fowler
Contribution of UGT Enzymes to Human Drug Metabolism Stereoselectivity: A Case Study of Medetomidine, RO5263397, Propranolol, and Testosterone. Drug metabolism and disposition: the biological fate of chemicals 51 (3) (2022)
Stephen Fowler, Andreas Brink, Yumi Cleary, Andreas Guenther, Katja Heinig, Christophe Husser, Heidemarie Kletzl, Nicole A Kratochwil, Lutz Mueller, Mark Savage, Cordula Stillhart, Dietrich W Tuerck, Mohammed Ullah, Kenichi Umehara, Agnès Poirier
Addressing today's ADME challenges in the translation of in vitro absorption, distribution, metabolism and excretion characteristics to human: A case study of the SMN2 mRNA splicing modifier risdiplam. Drug metabolism and disposition: the biological fate of chemicals (2021)
Stephen Fowler, Wen Li Kelly Chen, David B Duignan, Anshul Gupta, Niresh Hariparsad, Jane R Kenny, W George Lai, Jennifer Liras, Jonathan A Phillips, Jinping Gan
Microphysiological systems for ADME-related applications: current status and recommendations for system development and characterization. Lab on a chip 20 (3) (2020)
Kenichi Umehara, Carina Cantrill, Matthias Beat Wittwer, Elisa Di Lenarda, Florian Klammers, Aynur Ekiciler, Neil Parrott, Stephen Fowler, Mohammed Ullah
Application of the Extended Clearance Classification System (ECCS) in Drug Discovery and Development: Selection of Appropriate In Vitro Tools and Clearance Prediction. Drug metabolism and disposition: the biological fate of chemicals 48 (10) (2020)

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Publication Activity (10 Years)

Top Topics

Top Venues

Stephen Fowler