Aleksandra Galetin

Scopus Author ID ORCID

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 35

Top Topics

Helicobacter Pylori Infection

Chronic Kidney Disease

Top Venues

CPT: pharmacometrics & systems pharmacology

Clinical pharmacology and therapeutics

Molecular pharmaceutics

Nature reviews. Drug discovery

This page only lists publications with an associated author ORCID identifier.

Publications

Nicoló Milani, Neil John Parrott, Aleksandra Galetin, Stephen Fowler, Michael Gertz
In silico modeling and simulation of organ-on-a-chip systems to support data analysis and a priori experimental design. CPT: pharmacometrics & systems pharmacology 13 (4) (2024)
Shawn Pei Feng Tan, Annika Tillmann, Susan J Murby, Amin Rostami-Hodjegan, Daniel Scotcher, Aleksandra Galetin
Albumin-Mediated Drug Uptake by Organic Anion Transporter 1/3 Is Real: Implications for the Prediction of Active Renal Secretion Clearance. Molecular pharmaceutics 21 (9) (2024)
Amin Rostami-Hodjegan, Zubida M Al-Majdoub, Yannick von Grabowiecki, Ka Lai Yee, Sudhakar Sahoo, Wolfgang Breitwieser, Aleksandra Galetin, Christopher Gibson, Brahim Achour
Dealing With Variable Drug Exposure Due to Variable Hepatic Metabolism: A Proof-of-Concept Application of Liquid Biopsy in Renal Impairment. Clinical pharmacology and therapeutics 116 (3) (2024)
Aleksandra Galetin, Kim L R Brouwer, Donald Tweedie, Kenta Yoshida, Noora Sjöstedt, Lauren M Aleksunes, Xiaoyan Chu, Raymond Evers, Michael J Hafey, Yurong Lai, Pär Matsson, Andrew M Riselli, Hong Shen, Alex Sparreboom, Manthena V S Varma, Jia Yang, Xinning Yang, Sook Wah Yee, Maciej J Zamek-Gliszczynski, Lei Zhang, Kathleen M Giacomini
Membrane transporters in drug development and as determinants of precision medicine. Nature reviews. Drug discovery 23 (4) (2024)
Nicoló Milani, Neil John Parrott, Aleksandra Galetin, Stephen Fowler, Michael Gertz
In silico modeling and simulation of organ-on-a-chip systems to support data analysis and a priori experimental design. CPT: pharmacometrics & systems pharmacology 13 (4) (2024)
Aleksandra Galetin, Kim L R Brouwer, Donald Tweedie, Kenta Yoshida, Noora Sjöstedt, Lauren M Aleksunes, Xiaoyan Chu, Raymond Evers, Michael J Hafey, Yurong Lai, Pär Matsson, Andrew M Riselli, Hong Shen, Alex Sparreboom, Manthena V S Varma, Jia Yang, Xinning Yang, Sook Wah Yee, Maciej J Zamek-Gliszczynski, Lei Zhang, Kathleen M Giacomini
Membrane transporters in drug development and as determinants of precision medicine. Nature reviews. Drug discovery 23 (4) (2024)
Nicoló Milani, Neil John Parrott, Aleksandra Galetin, Stephen Fowler, Michael Gertz
In silico modeling and simulation of organ-on-a-chip systems to support data analysis and a priori experimental design. CPT: pharmacometrics & systems pharmacology (2024)
Shawn Pei Feng Tan, Annika Tillmann, Susan J Murby, Amin Rostami-Hodjegan, Daniel Scotcher, Aleksandra Galetin
Albumin-Mediated Drug Uptake by Organic Anion Transporter 1/3 Is Real: Implications for the Prediction of Active Renal Secretion Clearance. Molecular pharmaceutics (2024)
Amin Rostami-Hodjegan, Zubida M Al-Majdoub, Yannick von Grabowiecki, Ka Lai Yee, Sudhakar Sahoo, Wolfgang Breitwieser, Aleksandra Galetin, Christopher Gibson, Brahim Achour
Dealing With Variable Drug Exposure Due to Variable Hepatic Metabolism: A Proof-of-Concept Application of Liquid Biopsy in Renal Impairment. Clinical pharmacology and therapeutics (2024)
Aleksandra Galetin, Kim L R Brouwer, Donald Tweedie, Kenta Yoshida, Noora Sjöstedt, Lauren M Aleksunes, Xiaoyan Chu, Raymond Evers, Michael J Hafey, Yurong Lai, Pär Matsson, Andrew M Riselli, Hong Shen, Alex Sparreboom, Manthena V S Varma, Jia Yang, Xinning Yang, Sook Wah Yee, Maciej J Zamek-Gliszczynski, Lei Zhang, Kathleen M Giacomini
Membrane transporters in drug development and as determinants of precision medicine. Nature reviews. Drug discovery (2024)
Nicoló Milani, Neil John Parrott, Aleksandra Galetin, Stephen Fowler, Michael Gertz
In silico modeling and simulation of organ-on-a-chip systems to support data analysis and a priori experimental design. CPT: pharmacometrics & systems pharmacology 13 (4) (2024)
Nicoló Milani, Neil John Parrott, Aleksandra Galetin, Stephen Fowler, Michael Gertz
In silico modeling and simulation of organ-on-a-chip systems to support data analysis and a priori experimental design. CPT: pharmacometrics & systems pharmacology 13 (4) (2024)
Caroline Sychterz, Hong Shen, Yueping Zhang, Michael Sinz, Amin Rostami-Hodjegan, Brian James Schmidt, Lu Gaohua, Aleksandra Galetin
A close examination of BCRP's role in lactation and methods for predicting drug distribution into milk. CPT: pharmacometrics & systems pharmacology (2024)
Aleksandra Galetin, Kim L R Brouwer, Donald Tweedie, Kenta Yoshida, Noora Sjöstedt, Lauren M Aleksunes, Xiaoyan Chu, Raymond Evers, Michael J Hafey, Yurong Lai, Pär Matsson, Andrew M Riselli, Hong Shen, Alex Sparreboom, Manthena V S Varma, Jia Yang, Xinning Yang, Sook Wah Yee, Maciej J Zamek-Gliszczynski, Lei Zhang, Kathleen M Giacomini
Membrane transporters in drug development and as determinants of precision medicine. Nature reviews. Drug discovery 23 (4) (2024)
Nicoló Milani, Neil John Parrott, Aleksandra Galetin, Stephen Fowler, Michael Gertz
In silico modeling and simulation of organ-on-a-chip systems to support data analysis and a priori experimental design. CPT: pharmacometrics & systems pharmacology 13 (4) (2024)
Nicola Melillo, Daniel Scotcher, J Gerry Kenna, Claudia Green, Catherine D G Hines, Iina Laitinen, Paul D Hockings, Kayode Ogungbenro, Ebony R Gunwhy, Steven Sourbron, John Charles Waterton, Gunnar Schuetz, Aleksandra Galetin
Use of In Vivo Imaging and Physiologically-Based Kinetic Modelling to Predict Hepatic Transporter Mediated Drug-Drug Interactions in Rats. Pharmaceutics 15 (3) (2023)
Shawn Pei Feng Tan, Marie-Emilie Willemin, Jan Snoeys, Hong Shen, Amin Rostami-Hodjegan, Daniel Scotcher, Aleksandra Galetin
Development of 4-Pyridoxic Acid PBPK Model to Support Biomarker-Informed Evaluation of OAT1/3 Inhibition and Effect of Chronic Kidney Disease. Clinical pharmacology and therapeutics (2023)
Nicola Melillo, Daniel Scotcher, J Gerry Kenna, Claudia Green, Catherine D G Hines, Iina Laitinen, Paul D Hockings, Kayode Ogungbenro, Ebony R Gunwhy, Steven Sourbron, John Charles Waterton, Gunnar Schuetz, Aleksandra Galetin
Use of In Vivo Imaging and Physiologically-Based Kinetic Modelling to Predict Hepatic Transporter Mediated Drug-Drug Interactions in Rats. Pharmaceutics 15 (3) (2023)
Nicola Melillo, Daniel Scotcher, J Gerry Kenna, Claudia Green, Catherine D G Hines, Iina Laitinen, Paul D Hockings, Kayode Ogungbenro, Ebony R Gunwhy, Steven Sourbron, John Charles Waterton, Gunnar Schuetz, Aleksandra Galetin
Use of In Vivo Imaging and Physiologically-Based Kinetic Modelling to Predict Hepatic Transporter Mediated Drug-Drug Interactions in Rats. Pharmaceutics 15 (3) (2023)
Luca Docci, Nicoló Milani, Thomas Ramp, Andrea A Romeo, Patricio Godoy, Daniela Ortiz Franyuti, Stephan Krähenbühl, Michael Gertz, Aleksandra Galetin, Neil Parrott, Stephen Fowler
Exploration and application of a liver-on-a-chip device in combination with modelling and simulation for quantitative drug metabolism studies. Lab on a chip 22 (6) (2022)
Hiroyuki Takita, Daniel Scotcher, Xiaoyan Chu, Ka Lai Yee, Kayode Ogungbenro, Aleksandra Galetin
Coproporphyrin I as an Endogenous Biomarker to Detect Reduced OATP1B Activity and Shift in Elimination Route in Chronic Kidney Disease. Clinical pharmacology and therapeutics 112 (3) (2022)
Nicoló Milani, Neil Parrott, Daniela Ortiz Franyuti, Patricio Godoy, Aleksandra Galetin, Michael Gertz, Stephen Fowler
Application of a gut-liver-on-a-chip device and mechanistic modelling to the quantitative in vitro pharmacokinetic study of mycophenolate mofetil. Lab on a chip 22 (15) (2022)
Xiaoyan Chu, Bhagwat Prasad, Sibylle Neuhoff, Kenta Yoshida, James Steven Leeder, Dwaipayan Mukherjee, Kunal S Taskar, Manthena V S Varma, Xinyuan Zhang, Xinning Yang, Aleksandra Galetin
Clinical Implications of Altered Drug Transporter Abundance/Function and PBPK Modeling in Specific Populations: An ITC Perspective. Clinical pharmacology and therapeutics 112 (3) (2022)
Shawn Pei Feng Tan, Daniel Scotcher, Amin Rostami-Hodjegan, Aleksandra Galetin
Effect of Chronic Kidney Disease on the Renal Secretion via Organic Anion Transporters 1/3: Implications for Physiologically-Based Pharmacokinetic Modeling and Dose Adjustment. Clinical pharmacology and therapeutics 112 (3) (2022)
Hiroyuki Takita, Shelby Barnett, Yueping Zhang, Karelle Ménochet, Hong Shen, Kayode Ogungbenro, Aleksandra Galetin
PBPK Model of Coproporphyrin I: Evaluation of the Impact of SLCO1B1 Genotype, Ethnicity, and Sex on its Inter-Individual Variability. CPT: pharmacometrics & systems pharmacology 10 (2) (2021)
Daniel Scotcher, Nicola Melillo, Sirisha Tadimalla, Adam S Darwich, Sabina Ziemian, Kayode Ogungbenro, Gunnar Schütz, Steven Sourbron, Aleksandra Galetin
Physiologically Based Pharmacokinetic Modeling of Transporter-Mediated Hepatic Disposition of Imaging Biomarker Gadoxetate in Rats. Molecular pharmaceutics 18 (8) (2021)
Zubida M Al-Majdoub, Daniel Scotcher, Brahim Achour, Jill Barber, Aleksandra Galetin, Amin Rostami-Hodjegan
Quantitative Proteomic Map of Enzymes and Transporters in the Human Kidney: Stepping Closer to Mechanistic Kidney Models to Define Local Kinetics. Clinical pharmacology and therapeutics 110 (5) (2021)
Hiroyuki Takita, Daniel Scotcher, Rajkumar Chinnadurai, Philip A Kalra, Aleksandra Galetin
Physiologically-Based Pharmacokinetic Modelling of Creatinine-Drug Interactions in the Chronic Kidney Disease Population. CPT: pharmacometrics & systems pharmacology 9 (12) (2020)
Daniel Scotcher, Vikram Arya, Xinning Yang, Ping Zhao, Lei Zhang, Shiew Mei Huang, Amin Rostami-Hodjegan, Aleksandra Galetin
A Novel Physiologically Based Model of Creatinine Renal Disposition to Integrate Current Knowledge of Systems Parameters and Clinical Observations. CPT: pharmacometrics & systems pharmacology 9 (6) (2020)
Daniel Scotcher, Vikram Arya, Xinning Yang, Ping Zhao, Lei Zhang, Shiew Mei Huang, Amin Rostami-Hodjegan, Aleksandra Galetin
Mechanistic Models as Framework for Understanding Biomarker Disposition: Prediction of Creatinine-Drug Interactions. CPT: pharmacometrics & systems pharmacology 9 (5) (2020)
Maciej J Zamek-Gliszczynski, Mitesh Patel, Xinning Yang, Justin D Lutz, Xiaoyan Chu, Kim L R Brouwer, Yurong Lai, Caroline A Lee, Sibylle Neuhoff, Mary F Paine, Yuichi Sugiyama, Kunal S Taskar, Aleksandra Galetin
Intestinal P-gp and Putative Hepatic OATP1B Induction: International Transporter Consortium Perspective on Drug Development Implications. Clinical pharmacology and therapeutics 109 (1) (2020)
Thomas K van der Made, Michele Fedecostante, Daniel Scotcher, Amin Rostami-Hodjegan, Javier Sastre Toraño, Igor Middel, Andries S Koster, Karin G Gerritsen, Vera Jankowski, Joachim Jankowski, Joost G J Hoenderop, Rosalinde Masereeuw, Aleksandra Galetin
Quantitative Translation of Microfluidic Transporter in Vitro Data to in Vivo Reveals Impaired Albumin-Facilitated Indoxyl Sulfate Secretion in Chronic Kidney Disease. Molecular pharmaceutics 16 (11) (2019)
Ayşe Ufuk, Rachel E Kosa, Hongying Gao, Yi-An Bi, Sweta Modi, Dana Gates, A David Rodrigues, Larry M Tremaine, Manthena V S Varma, J Brian Houston, Aleksandra Galetin
In Vitro-In Vivo Extrapolation of OATP1B-Mediated Drug-Drug Interactions in Cynomolgus Monkey. The Journal of pharmacology and experimental therapeutics 365 (3) (2018)
Takanobu Matsuzaki, Daniel Scotcher, Adam S Darwich, Aleksandra Galetin, Amin Rostami-Hodjegan
Towards Further Verification of Physiologically-Based Kidney Models: Predictability of the Effects of Urine-Flow and Urine-pH on Renal Clearance. The Journal of pharmacology and experimental therapeutics 368 (2) (2018)
Ayşe Ufuk, Frauke Assmus, Laura Francis, Jonathan Plumb, Valeriu Damian, Michael Gertz, J Brian Houston, Aleksandra Galetin
In Vitro and in Silico Tools To Assess Extent of Cellular Uptake and Lysosomal Sequestration of Respiratory Drugs in Human Alveolar Macrophages. Molecular pharmaceutics 14 (4) (2017)